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Conserved domains on  [gi|15224761|ref|NP_179523|]
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plant intracellular ras group-related LRR 6 [Arabidopsis thaliana]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
54-292 2.29e-35

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 133.91  E-value: 2.29e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761  54 FNNNEEERLEVVNLSGMALESLPNPSLNLAQICKLDLSNNhlqtipeSLTARLLNLIALDVHSNQIKALPNSIGCLSKLK 133
Cdd:COG4886  67 LLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLK 139

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761 134 TLNVSGNFLVSFPKSIQHCRSLEELNANFNKLIRLPDSIGfELTNLRKLSINSNKLISLPISITHLTSLRVLDARLNCLM 213
Cdd:COG4886 140 ELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15224761 214 ILPDDLENLINLEILNVSQNfqYLSALPsSIGLLMNLIELDVSYNKITVLPESiGCMRRLRKLSVEGNPLVSPPIEVME 292
Cdd:COG4886 219 DLPEPLANLTNLETLDLSNN--QLTDLP-ELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDLKLKELE 293
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
54-292 2.29e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 133.91  E-value: 2.29e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761  54 FNNNEEERLEVVNLSGMALESLPNPSLNLAQICKLDLSNNhlqtipeSLTARLLNLIALDVHSNQIKALPNSIGCLSKLK 133
Cdd:COG4886  67 LLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLK 139

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761 134 TLNVSGNFLVSFPKSIQHCRSLEELNANFNKLIRLPDSIGfELTNLRKLSINSNKLISLPISITHLTSLRVLDARLNCLM 213
Cdd:COG4886 140 ELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15224761 214 ILPDDLENLINLEILNVSQNfqYLSALPsSIGLLMNLIELDVSYNKITVLPESiGCMRRLRKLSVEGNPLVSPPIEVME 292
Cdd:COG4886 219 DLPEPLANLTNLETLDLSNN--QLTDLP-ELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDLKLKELE 293
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
55-307 1.05e-20

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 93.99  E-value: 1.05e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761   55 NNNEEERLEVVNLSGMAlESLPNpslnlaQICKLDLSNNHLQTIPESLTArllNLIALDVHSNQIKALPNSIGclSKLKT 134
Cdd:PRK15370 178 NNKTELRLKILGLTTIP-ACIPE------QITTLILDNNELKSLPENLQG---NIKTLYANSNQLTSIPATLP--DTIQE 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761  135 LNVSGNFLVSFPKSIQhcRSLEELNANFNKLIRLPDSIGFELtnlRKLSINSNKLISLPisiTHL-TSLRVLDARLNCLM 213
Cdd:PRK15370 246 MELSINRITELPERLP--SALQSLDLFHNKISCLPENLPEEL---RYLSVYDNSIRTLP---AHLpSGITHLNVQSNSLT 317

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761  214 ILPDDLEnlINLEILNVSQNfqYLSALPSSigLLMNLIELDVSYNKITVLPESIGcmRRLRKLSVEGNPLVSPPievmeQ 293
Cdd:PRK15370 318 ALPETLP--PGLKTLEAGEN--ALTSLPAS--LPPELQVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLP-----E 384

                        250
                 ....*....|....
gi 15224761  294 NLQVVREYLTQKMN 307
Cdd:PRK15370 385 NLPAALQIMQASRN 398
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 82-287 1.43e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.27  E-value: 1.43e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761  82 LAQICKLDLSNNHLQTIPESLTARllNLIALDVHSNQIKALPNsIGCLSKLKTLNVSGNFLVSFPkSIQHCRSLEELNAN 161
Cdd:cd21340   1 LKRITHLYLNDKNITKIDNLSLCK--NLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761 162 FNKLIRLpdsIGFE-LTNLRKLSI------NSNKLISLPISITHL-TSLRVLDARLNCLMILpDDLENLINLEILNVSQN 233
Cdd:cd21340  77 GNRISVV---EGLEnLTNLEELHIenqrlpPGEKLTFDPRSLAALsNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNN 152

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 15224761 234 fqylsalpssigllmNLieldvsyNKITVLPESIGCMRRLRKLSVEGNPLVSPP 287
Cdd:cd21340 153 ---------------QI-------SDLEELLDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
87-140 8.24e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 8.24e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 15224761    87 KLDLSNNHLQTIPESLTARLLNLIALDVHSNQIKAL-PNSIGCLSKLKTLNVSGN 140
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGN 59
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
54-292 2.29e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 133.91  E-value: 2.29e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761  54 FNNNEEERLEVVNLSGMALESLPNPSLNLAQICKLDLSNNhlqtipeSLTARLLNLIALDVHSNQIKALPNSIGCLSKLK 133
Cdd:COG4886  67 LLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLK 139

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761 134 TLNVSGNFLVSFPKSIQHCRSLEELNANFNKLIRLPDSIGfELTNLRKLSINSNKLISLPISITHLTSLRVLDARLNCLM 213
Cdd:COG4886 140 ELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15224761 214 ILPDDLENLINLEILNVSQNfqYLSALPsSIGLLMNLIELDVSYNKITVLPESiGCMRRLRKLSVEGNPLVSPPIEVME 292
Cdd:COG4886 219 DLPEPLANLTNLETLDLSNN--QLTDLP-ELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDLKLKELE 293
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
77-298 1.36e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 123.89  E-value: 1.36e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761  77 NPSLNLAQICKLDLSNNHLQTIPESLTARLLNLIALDVHSNqikalpNSIGCLSKLKTLNVSGNFLVSFPKSIQHCRSLE 156
Cdd:COG4886  66 LLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLK 139

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761 157 ELNANFNKLIRLPDSIGfELTNLRKLSINSNKLISLPISITHLTSLRVLDARLNCLMILPDDLENLINLEILNVSQNfqY 236
Cdd:COG4886 140 ELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN--Q 216

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15224761 237 LSALPSSIGLLMNLIELDVSYNKITVLPEsIGCMRRLRKLSVEGNPLVSPPIEVMEQNLQVV 298
Cdd:COG4886 217 LTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPLANLTNLKTL 277
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-287 8.49e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.41  E-value: 8.49e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761  56 NNEEERLEVVNLSGMALESLPNPSLNLAQICKLDLSNNHLQTIPESLTARLLNLIALDVhSNQIKALPNSIGCLSKLKTL 135
Cdd:COG4886  23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL-LSLLLLGLTDLGDLTNLTEL 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761 136 NVSGNflvsfpKSIQHCRSLEELNANFNKLIRLPDSIGfELTNLRKLSINSNKLISLPISITHLTSLRVLDARLNCLMIL 215
Cdd:COG4886 102 DLSGN------EELSNLTNLESLDLSGNQLTDLPEELA-NLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDL 174

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15224761 216 PDDLENLINLEILNVSQNFqyLSALPSSIGLLMNLIELDVSYNKITVLPESIGCMRRLRKLSVEGNPLVSPP 287
Cdd:COG4886 175 PEELGNLTNLKELDLSNNQ--ITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP 244
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
55-307 1.05e-20

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 93.99  E-value: 1.05e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761   55 NNNEEERLEVVNLSGMAlESLPNpslnlaQICKLDLSNNHLQTIPESLTArllNLIALDVHSNQIKALPNSIGclSKLKT 134
Cdd:PRK15370 178 NNKTELRLKILGLTTIP-ACIPE------QITTLILDNNELKSLPENLQG---NIKTLYANSNQLTSIPATLP--DTIQE 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761  135 LNVSGNFLVSFPKSIQhcRSLEELNANFNKLIRLPDSIGFELtnlRKLSINSNKLISLPisiTHL-TSLRVLDARLNCLM 213
Cdd:PRK15370 246 MELSINRITELPERLP--SALQSLDLFHNKISCLPENLPEEL---RYLSVYDNSIRTLP---AHLpSGITHLNVQSNSLT 317

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761  214 ILPDDLEnlINLEILNVSQNfqYLSALPSSigLLMNLIELDVSYNKITVLPESIGcmRRLRKLSVEGNPLVSPPievmeQ 293
Cdd:PRK15370 318 ALPETLP--PGLKTLEAGEN--ALTSLPAS--LPPELQVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLP-----E 384

                        250
                 ....*....|....
gi 15224761  294 NLQVVREYLTQKMN 307
Cdd:PRK15370 385 NLPAALQIMQASRN 398
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
62-264 4.78e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.76  E-value: 4.78e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761  62 LEVVNLSGMALESLPNPSLNLAQICKLDLSNNHLQTIPESLtARLLNLIALDVHSNQIKALPNSIGCLSKLKTLNVSGNF 141
Cdd:COG4886 161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQ 239

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761 142 LVSFPkSIQHCRSLEELNANFNKLIRLPDSigFELTNLRKLSINSNKLISLpisithltSLRVLDARLNCLMILPDDLEN 221
Cdd:COG4886 240 LTDLP-ELGNLTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDL--------KLKELELLLGLNSLLLLLLLL 308

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 15224761 222 LINLEILNVSQNFQYLSALPSSIGLLMNLIELDVSYNKITVLP 264
Cdd:COG4886 309 NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 62-317 5.67e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 76.81  E-value: 5.67e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761   62 LEVVNLSGMALE-SLPNPSLNLA-QICKLDLSNNHLQ-TIPEsltARLLNLIALDVHSNQIKA-LPNSIGCLSKLKTLNV 137
Cdd:PLN00113  95 IQTINLSNNQLSgPIPDDIFTTSsSLRYLNLSNNNFTgSIPR---GSIPNLETLDLSNNMLSGeIPNDIGSFSSLKVLDL 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761  138 SGNFLVS-FPKSIQHCRSLEELNANFNKLI-RLPDSIGfELTNLRKLSINSNKLI-SLPISITHLTSLRVLDARLNCLM- 213
Cdd:PLN00113 172 GGNVLVGkIPNSLTNLTSLEFLTLASNQLVgQIPRELG-QMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLTg 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761  214 ILPDDLENLINLEILNVSQNfQYLSALPSSIGLLMNLIELDVSYNKIT-VLPESIGCMRRLRKLSVEGNPLVSP-PIEVM 291
Cdd:PLN00113 251 PIPSSLGNLKNLQYLFLYQN-KLSGPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTGKiPVALT 329

                        250       260
                 ....*....|....*....|....*..
gi 15224761  292 E-QNLQVVREYlTQKMNGGSPRSPSKK 317
Cdd:PLN00113 330 SlPRLQVLQLW-SNKFSGEIPKNLGKH 355
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-254 1.35e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.50  E-value: 1.35e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761  61 RLEVVNLSGMALESLPNPSLNLAQICKLDLSNNHLQTIPESLtARLLNLIALDVHSNQIKALPnSIGCLSKLKTLNVSGN 140
Cdd:COG4886 183 NLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNN 260

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761 141 FLVSFPKSIQhCRSLEELNANFNKLIRLPDSIGFELTNLRKLSINSNKLISLPISITHLTSLRVLDARLNCLMILPDDLE 220
Cdd:COG4886 261 QLTDLPPLAN-LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339

                       170       180       190
                ....*....|....*....|....*....|....
gi 15224761 221 NLINLEILNVSQNFQYLSALPSSIGLLMNLIELD 254
Cdd:COG4886 340 LALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
62-300 2.89e-13

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 71.35  E-value: 2.89e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761   62 LEVVNLSGMALESLPNPSLNLAQICKLDLSNNHLQTIPESLTArllnliaLDVHSNQIKALPNsigCLSKLKTLNVSGNF 141
Cdd:PRK15387 244 LRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCK-------LWIFGNQLTSLPV---LPPGLQELSVSDNQ 313

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761  142 LVSFPKSIQHCRSLEELNANFNKLIRLPdsigfelTNLRKLSINSNKLISLPISITHLTSLRVLDARLNCLMILPDDLEN 221
Cdd:PRK15387 314 LASLPALPSELCKLWAYNNQLTSLPTLP-------SGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKE 386

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761  222 LInleilnVSQN-FQYLSALPSSIGLLM--------------NLIELDVSYNKITVLPESIGCMRRLRKLSVEGNPLvsp 286
Cdd:PRK15387 387 LI------VSGNrLTSLPVLPSELKELMvsgnrltslpmlpsGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPL--- 457

                        250
                 ....*....|....
gi 15224761  287 pievMEQNLQVVRE 300
Cdd:PRK15387 458 ----SERTLQALRE 467
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 82-287 1.43e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.27  E-value: 1.43e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761  82 LAQICKLDLSNNHLQTIPESLTARllNLIALDVHSNQIKALPNsIGCLSKLKTLNVSGNFLVSFPkSIQHCRSLEELNAN 161
Cdd:cd21340   1 LKRITHLYLNDKNITKIDNLSLCK--NLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761 162 FNKLIRLpdsIGFE-LTNLRKLSI------NSNKLISLPISITHL-TSLRVLDARLNCLMILpDDLENLINLEILNVSQN 233
Cdd:cd21340  77 GNRISVV---EGLEnLTNLEELHIenqrlpPGEKLTFDPRSLAALsNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNN 152

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 15224761 234 fqylsalpssigllmNLieldvsyNKITVLPESIGCMRRLRKLSVEGNPLVSPP 287
Cdd:cd21340 153 ---------------QI-------SDLEELLDLLSSWPSLRELDLTGNPVCKKP 184
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
62-172 1.04e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 57.01  E-value: 1.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761   62 LEVVNLSGMAL-ESLPnPSLNLaqickLDLSNNHLQTIPESLTARLLNLialDVHSNQIKALPNSIGclSKLKTLNVSGN 140
Cdd:PRK15370 309 LNVQSNSLTALpETLP-PGLKT-----LEAGENALTSLPASLPPELQVL---DVSKNQITVLPETLP--PTITTLDVSRN 377

                         90       100       110
                 ....*....|....*....|....*....|..
gi 15224761  141 FLVSFPKSIQhcRSLEELNANFNKLIRLPDSI 172
Cdd:PRK15370 378 ALTNLPENLP--AALQIMQASRNNLVRLPESL 407
PLN03150 PLN03150
hypothetical protein; Provisional
 215-283 1.82e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 52.90  E-value: 1.82e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761  215 LPDDLENLINLEILNVSQNFQYlSALPSSIGLLMNLIELDVSYNKIT-VLPESIGCMRRLRKLSVEGNPL 283
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIR-GNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502
PLN03150 PLN03150
hypothetical protein; Provisional
 122-189 4.22e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 51.74  E-value: 4.22e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761  122 LPNSIGCLSKLKTLNVSGNFLV-SFPKSIQHCRSLEELNANFNKLI-RLPDSIGfELTNLRKLSINSNKL 189
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLG-QLTSLRILNLNGNSL 502
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 71-283 5.70e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.77  E-value: 5.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761   71 ALESLPNpslnlAQICKLdLSNNHLQTIPESLTARLlNLIALDVHSNQIKA-LPNSIGCLSKLKTLNVSGNFLVS-FPKS 148
Cdd:PLN00113 327 ALTSLPR-----LQVLQL-WSNKFSGEIPKNLGKHN-NLTVLDLSTNNLTGeIPEGLCSSGNLFKLILFSNSLEGeIPKS 399

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761  149 IQHCRSLE-----------ELNANFNKLirlpdsigfELTNLrkLSINSNKLI-SLPISITHLTSLRVLD-ARLNCLMIL 215
Cdd:PLN00113 400 LGACRSLRrvrlqdnsfsgELPSEFTKL---------PLVYF--LDISNNNLQgRINSRKWDMPSLQMLSlARNKFFGGL 468

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15224761  216 PDDLENLiNLEILNVSQNfQYLSALPSSIGLLMNLIELDVSYNKIT-VLPESIGCMRRLRKLSVEGNPL 283
Cdd:PLN00113 469 PDSFGSK-RLENLDLSRN-QFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQL 535
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
128-283 3.36e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.78  E-value: 3.36e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761 128 CLSKLKTLNVSGNFLVSFPKSIQHCRSLEELNANFNKLIRLPDSIGFELTNLRKLSINSNKLISLPISITHLTSLRVLDA 207
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15224761 208 RLNCLMILPDDLENLINLEILNVSQNfqylsalpSSIGLLMNLIELDVSYNKITVLPESIGCMRRLRKLSVEGNPL 283
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQL 148
LRR_8 pfam13855
Leucine rich repeat;
87-140 8.24e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 8.24e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 15224761    87 KLDLSNNHLQTIPESLTARLLNLIALDVHSNQIKAL-PNSIGCLSKLKTLNVSGN 140
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 81-206 2.84e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.78  E-value: 2.84e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761  81 NLAQICKLDLSNNHLQTIpESLTaRLLNLIALDVhSNQIKAL-------PNSIGCLSK-LKTLNVSGNFLVSfPKSIQHC 152
Cdd:cd21340  66 NLVNLKKLYLGGNRISVV-EGLE-NLTNLEELHI-ENQRLPPgekltfdPRSLAALSNsLRVLNISGNNIDS-LEPLAPL 141

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15224761 153 RSLEELNANFNKLIRLPDSIGF--ELTNLRKLSINSNklislPIS---------ITHLTSLRVLD 206
Cdd:cd21340 142 RNLEQLDASNNQISDLEELLDLlsSWPSLRELDLTGN-----PVCkkpkyrdkiILASKSLEVLD 201
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-251 3.86e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.23  E-value: 3.86e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761  61 RLEVVNLSGMALESLPNPSlNLAQICKLDLSNNHLQTIPESltARLLNLIALDVHSNQIKALpnSIGCLSKLKTLNVSGN 140
Cdd:COG4886 229 NLETLDLSNNQLTDLPELG-NLTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDL--KLKELELLLGLNSLLL 303

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761 141 FLVSFPKSIQHCRSLEELNANFNKLIRLPDSIGFELTNLRKLSINSNKLISLPISITHLTSLRVLDARLNCLMILPDDLE 220
Cdd:COG4886 304 LLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLA 383

                       170       180       190
                ....*....|....*....|....*....|.
gi 15224761 221 NLINLEILNVSQNFQYLSALPSSIGLLMNLI 251
Cdd:COG4886 384 LLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
LRR_8 pfam13855
Leucine rich repeat;
224-283 6.16e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 6.16e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15224761   224 NLEILNVSQNfqYLSAL-PSSIGLLMNLIELDVSYNKITVL-PESIGCMRRLRKLSVEGNPL 283
Cdd:pfam13855   2 NLRSLDLSNN--RLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
158-287 9.17e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 41.30  E-value: 9.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761  158 LNANFNKLIRLPDSIGFELTNLrklSINSNKLISLPISITHLTSLRVLDARLNCLMILPDDLenlinLEILNVSQNFQYL 237
Cdd:PRK15387 206 LNVGESGLTTLPDCLPAHITTL---VIPDNNLTSLPALPPELRTLEVSGNQLTSLPVLPPGL-----LELSIFSNPLTHL 277

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 15224761  238 SALPSSigllmnLIELDVSYNKITVLPEsigCMRRLRKLSVEGNPLVSPP 287
Cdd:PRK15387 278 PALPSG------LCKLWIFGNQLTSLPV---LPPGLQELSVSDNQLASLP 318
LRR_8 pfam13855
Leucine rich repeat;
177-233 9.68e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 9.68e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 15224761   177 TNLRKLSINSNKLISL-PISITHLTSLRVLDARLNCLMIL-PDDLENLINLEILNVSQN 233
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
153-206 1.23e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 1.23e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 15224761   153 RSLEELNANFNKLIRLPDSIGFELTNLRKLSINSNKLISL-PISITHLTSLRVLD 206
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLD 55
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 60-206 1.24e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 41.01  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761    60 ERLEVVNLSGMA-LESLPNPSLNlaqICKLDLSNNHLQTIPESLtaRLLNLIALDVHSNQIKALPNSIGCLSKLKT---- 134
Cdd:PLN03210  704 KSLYRLNLSGCSrLKSFPDISTN---ISWLDLDETAIEEFPSNL--RLENLDELILCEMKSEKLWERVQPLTPLMTmlsp 778

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761   135 ----LNVSGN-FLVSFPKSIQHCRSLEELN-ANFNKLIRLPDSIGFEL-------------------TNLRKLSINSNKL 189
Cdd:PLN03210  779 sltrLFLSDIpSLVELPSSIQNLHKLEHLEiENCINLETLPTGINLESlesldlsgcsrlrtfpdisTNISDLNLSRTGI 858

                         170
                  ....*....|....*..
gi 15224761   190 ISLPISITHLTSLRVLD 206
Cdd:PLN03210  859 EEVPWWIEKFSNLSFLD 875
PLN03150 PLN03150
hypothetical protein; Provisional
 172-245 1.52e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 1.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761  172 IGFELTNLRKL-SIN-SNKLI--SLPISITHLTSLRVLDARLNCLM-ILPDDLENLINLEILNVSQNFqyLSA-LPSSIG 245
Cdd:PLN03150 434 IPNDISKLRHLqSINlSGNSIrgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNS--LSGrVPAALG 511
PLN03150 PLN03150
hypothetical protein; Provisional
 75-142 2.13e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.18  E-value: 2.13e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761   75 LPNPSLNLAQICKLDLSNNHLQ-TIPESLtARLLNLIALDVHSNQIK-ALPNSIGCLSKLKTLNVSGNFL 142
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSL-GSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502
LRR_8 pfam13855
Leucine rich repeat;
108-165 3.07e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 3.07e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224761   108 NLIALDVHSNQIKAL-PNSIGCLSKLKTLNVSGNFLVSF-PKSIQHCRSLEELNANFNKL 165
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
130-189 6.11e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.81  E-value: 6.11e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15224761   130 SKLKTLNVSGNFLVSF-PKSIQHCRSLEELNANFNKLIRLPDSIGFELTNLRKLSINSNKL 189
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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