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Conserved domains on  [gi|15224999|ref|NP_181434|]
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plasma membrane intrinsic protein 2E [Arabidopsis thaliana]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 11088534)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11473620|8849412|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 30-265 3.13e-93

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


:

Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 274.97  E-value: 3.13e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999    30 ELKKWSFYRAVIAEFIATLLFLYVTVLTVIGFksqtdiNAGGGACASVGLLGISWAFGGMIFILVYCTAGISGGHINPAV 109
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGV------KKLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAV 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999   110 TFGLFLASKVSLVRAVSYMVAQCLGATCGVGLVKVFQSTyYNRYGGGANMLSDGYNVGVGVGAEIIGTFVLVYTVFSATD 189
Cdd:pfam00230  75 TLALLVGRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVG-LQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTD 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15224999   190 PKRNARDSHIpvlAPLPIGFSVFMVHLATIPITGTGINPARSFGAAVIYNNqkaWDDQWIFWVGPFVGAAIAAFYH 265
Cdd:pfam00230 154 DRRNGSLGTV---APLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWK---WDDHWVYWVGPFIGAALGALVY 223
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 30-265 3.13e-93

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 274.97  E-value: 3.13e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999    30 ELKKWSFYRAVIAEFIATLLFLYVTVLTVIGFksqtdiNAGGGACASVGLLGISWAFGGMIFILVYCTAGISGGHINPAV 109
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGV------KKLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAV 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999   110 TFGLFLASKVSLVRAVSYMVAQCLGATCGVGLVKVFQSTyYNRYGGGANMLSDGYNVGVGVGAEIIGTFVLVYTVFSATD 189
Cdd:pfam00230  75 TLALLVGRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVG-LQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTD 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15224999   190 PKRNARDSHIpvlAPLPIGFSVFMVHLATIPITGTGINPARSFGAAVIYNNqkaWDDQWIFWVGPFVGAAIAAFYH 265
Cdd:pfam00230 154 DRRNGSLGTV---APLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWK---WDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 38-268 5.62e-76

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 231.37  E-value: 5.62e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999  38 RAVIAEFIATLLFLYVTVLTVIGFKsqtdinagGGACASVGLLGISWAFGGMIFILVYCTAGISGGHINPAVTFGLFLAS 117
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVK--------LAGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGG 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999 118 KVSLVRAVSYMVAQCLGATCGVGLVKVFQSTYYNRYGGGANM--------LSDGYNVGVGVGAEIIGTFVLVYTVFSATD 189
Cdd:cd00333  73 RFPLIRVIPYIIAQLLGAILGAALLYGLYYGLYLEFLGANNIvagifgtyPSPGVSNGNAFFVEFIGTFILVLVVFATTD 152

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15224999 190 PKRNArdsHIPVLAPLPIGFSVFMVHLATIPITGTGINPARSFGAAVIYNNQKAWDDQWIFWVGPFVGAAIAAFYHQFV 268
Cdd:cd00333 153 DPNGP---PPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARHWHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 42-265 5.47e-64

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 200.22  E-value: 5.47e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999    42 AEFIATLLFLYVTVLTVIGFKSQTDINAGGGAcasvGLLGISWAFGGMIFILVYCTAGISGGHINPAVTFGLFLASKVSL 121
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYGAVGGG----QFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999   122 VRAVSYMVAQCLGATCGVGLVKVFQSTYYNRYGGGANMLSDGYNVGVGVGAEIIGTFVLVYTVFSATDpKRNARDSHIpv 201
Cdd:TIGR00861  77 KRVPVYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAGVSSGQAFFVEFIGTAILVLVIFATTD-DRNRVPRGG-- 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15224999   202 LAPLPIGFSVFMVHLATIPITGTGINPARSFGAAVIyNNQKAWDDQWIFWVGPFVGAAIAAFYH 265
Cdd:TIGR00861 154 FAPLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALF-AGLAGWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 35-270 3.06e-56

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 181.09  E-value: 3.06e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999  35 SFYRAVIAEFIAT--LLFLYVTVLTVIGfksqtdinaggGACASVGLLGISWAFGGMIFILVYCTAGISGGHINPAVTFG 112
Cdd:COG0580   1 SLMKRLLAEFLGTfiLVLLGCGVVAVLA-----------GTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLA 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999 113 LFLASKVSLVRAVSYMVAQCLGATCGVGLVKVFQSTYYNRYGGGANML-------SDGYNVGVGVGAEIIGTFVLVYTVF 185
Cdd:COG0580  70 LAVAGRFPWKDVLPYIIAQLLGAFLGAALVYLIYGGHFDATEDGGAKLgvfatspAIGYSLGAAFLTEIIGTFVLVFVIL 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999 186 SATDPKRNARdshipVLAPLPIGFSVFMVHLATIPITGTGINPARSFGAAVIYNNQK---AWDDQWIFWVGPFVGAAIAA 262
Cdd:COG0580 150 GITDKRAAPG-----GLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHALGKggsDWGYLWVPIVAPILGAALAA 224


                ....*...
gi 15224999 263 FYHQFVLR 270
Cdd:COG0580 225 LLYRALFG 232
PLN00027 PLN00027
aquaporin TIP; Provisional
 38-268 1.51e-40

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 141.08  E-value: 1.51e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999   38 RAVIAEFIATLLFLYVTVLTVIGFKSQTDinagGGACASVGLLGISWAFGGMIFILVYCTAGISGGHINPAVTFGLFLAS 117
Cdd:PLN00027  21 KAALAEFISTLIFVFAGEGSGMAFNKLTD----NGSTTPAGLVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFIGG 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999  118 KVSLVRAVSYMVAQCLGATCGVGLVKVfqSTyynryGG---GANMLSDGYNVGVGVGAEIIGTFVLVYTVF-SATDPKRn 193
Cdd:PLN00027  97 NITLLRGILYWIAQLLGSVVACLLLKF--ST-----GGletSAFSLSSGVGVWNAFVFEIVMTFGLVYTVYaTAVDPKK- 168

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15224999  194 ardSHIPVLAPLPIGFSVFMVHLATIPITGTGINPARSFGAAVIYNNqkaWDDQWIFWVGPFVGAAIAAFYHQFV 268
Cdd:PLN00027 169 ---GDLGIIAPIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWT---WTNHWVYWAGPLIGGGIAGLVYELI 237
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 30-265 3.13e-93

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 274.97  E-value: 3.13e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999    30 ELKKWSFYRAVIAEFIATLLFLYVTVLTVIGFksqtdiNAGGGACASVGLLGISWAFGGMIFILVYCTAGISGGHINPAV 109
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGV------KKLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAV 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999   110 TFGLFLASKVSLVRAVSYMVAQCLGATCGVGLVKVFQSTyYNRYGGGANMLSDGYNVGVGVGAEIIGTFVLVYTVFSATD 189
Cdd:pfam00230  75 TLALLVGRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVG-LQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTD 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15224999   190 PKRNARDSHIpvlAPLPIGFSVFMVHLATIPITGTGINPARSFGAAVIYNNqkaWDDQWIFWVGPFVGAAIAAFYH 265
Cdd:pfam00230 154 DRRNGSLGTV---APLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWK---WDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 38-268 5.62e-76

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 231.37  E-value: 5.62e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999  38 RAVIAEFIATLLFLYVTVLTVIGFKsqtdinagGGACASVGLLGISWAFGGMIFILVYCTAGISGGHINPAVTFGLFLAS 117
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVK--------LAGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGG 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999 118 KVSLVRAVSYMVAQCLGATCGVGLVKVFQSTYYNRYGGGANM--------LSDGYNVGVGVGAEIIGTFVLVYTVFSATD 189
Cdd:cd00333  73 RFPLIRVIPYIIAQLLGAILGAALLYGLYYGLYLEFLGANNIvagifgtyPSPGVSNGNAFFVEFIGTFILVLVVFATTD 152

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15224999 190 PKRNArdsHIPVLAPLPIGFSVFMVHLATIPITGTGINPARSFGAAVIYNNQKAWDDQWIFWVGPFVGAAIAAFYHQFV 268
Cdd:cd00333 153 DPNGP---PPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARHWHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 42-265 5.47e-64

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 200.22  E-value: 5.47e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999    42 AEFIATLLFLYVTVLTVIGFKSQTDINAGGGAcasvGLLGISWAFGGMIFILVYCTAGISGGHINPAVTFGLFLASKVSL 121
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYGAVGGG----QFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999   122 VRAVSYMVAQCLGATCGVGLVKVFQSTYYNRYGGGANMLSDGYNVGVGVGAEIIGTFVLVYTVFSATDpKRNARDSHIpv 201
Cdd:TIGR00861  77 KRVPVYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAGVSSGQAFFVEFIGTAILVLVIFATTD-DRNRVPRGG-- 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15224999   202 LAPLPIGFSVFMVHLATIPITGTGINPARSFGAAVIyNNQKAWDDQWIFWVGPFVGAAIAAFYH 265
Cdd:TIGR00861 154 FAPLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALF-AGLAGWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 35-270 3.06e-56

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 181.09  E-value: 3.06e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999  35 SFYRAVIAEFIAT--LLFLYVTVLTVIGfksqtdinaggGACASVGLLGISWAFGGMIFILVYCTAGISGGHINPAVTFG 112
Cdd:COG0580   1 SLMKRLLAEFLGTfiLVLLGCGVVAVLA-----------GTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLA 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999 113 LFLASKVSLVRAVSYMVAQCLGATCGVGLVKVFQSTYYNRYGGGANML-------SDGYNVGVGVGAEIIGTFVLVYTVF 185
Cdd:COG0580  70 LAVAGRFPWKDVLPYIIAQLLGAFLGAALVYLIYGGHFDATEDGGAKLgvfatspAIGYSLGAAFLTEIIGTFVLVFVIL 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999 186 SATDPKRNARdshipVLAPLPIGFSVFMVHLATIPITGTGINPARSFGAAVIYNNQK---AWDDQWIFWVGPFVGAAIAA 262
Cdd:COG0580 150 GITDKRAAPG-----GLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHALGKggsDWGYLWVPIVAPILGAALAA 224


                ....*...
gi 15224999 263 FYHQFVLR 270
Cdd:COG0580 225 LLYRALFG 232
PLN00027 PLN00027
aquaporin TIP; Provisional
 38-268 1.51e-40

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 141.08  E-value: 1.51e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999   38 RAVIAEFIATLLFLYVTVLTVIGFKSQTDinagGGACASVGLLGISWAFGGMIFILVYCTAGISGGHINPAVTFGLFLAS 117
Cdd:PLN00027  21 KAALAEFISTLIFVFAGEGSGMAFNKLTD----NGSTTPAGLVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFIGG 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999  118 KVSLVRAVSYMVAQCLGATCGVGLVKVfqSTyynryGG---GANMLSDGYNVGVGVGAEIIGTFVLVYTVF-SATDPKRn 193
Cdd:PLN00027  97 NITLLRGILYWIAQLLGSVVACLLLKF--ST-----GGletSAFSLSSGVGVWNAFVFEIVMTFGLVYTVYaTAVDPKK- 168

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15224999  194 ardSHIPVLAPLPIGFSVFMVHLATIPITGTGINPARSFGAAVIYNNqkaWDDQWIFWVGPFVGAAIAAFYHQFV 268
Cdd:PLN00027 169 ---GDLGIIAPIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWT---WTNHWVYWAGPLIGGGIAGLVYELI 237
PLN00166 PLN00166
aquaporin TIP2; Provisional
 38-265 1.35e-36

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 130.83  E-value: 1.35e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999   38 RAVIAEFIATLLFLYVTVLTVIGFKSQTDinagGGACASVGLLGISWAFGGMIFILVYCTAGISGGHINPAVTFGLFLAS 117
Cdd:PLN00166  19 KAYLSEFIATLLFVFAGVGSAIAFAKLTS----DAALDPAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGG 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999  118 KVSLVRAVSYMVAQCLGATCGVGLVKVFQSTYYNRYGGganmLSDGYNVGVGVGAEIIGTFVLVYTVF-SATDPKRNArd 196
Cdd:PLN00166  95 NITIITGFFYWIAQCLGSIVACLLLVFVTNGESVPTHG----VAAGLGAIEGVVMEIVVTFALVYTVYaTAADPKKGS-- 168

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15224999  197 shIPVLAPLPIGFSVFMVHLATIPITGTGINPARSFGAAVIYNNqkaWDDQWIFWVGPFVGAAIAAFYH 265
Cdd:PLN00166 169 --LGTIAPIAIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGD---FSQIWIYWVGPLVGGALAGLIY 232
PRK05420 PRK05420
aquaporin Z; Provisional
 77-273 3.08e-32

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 118.92  E-value: 3.08e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999   77 VGLLGISWAFGGMIFILVYCTAGISGGHINPAVTFGLFLASKVSLVRAVSYMVAQCLGATCGVGLVKVFQSTYYNRYGGG 156
Cdd:PRK05420  34 IGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKELVPYIIAQVVGGIAAAAVLYLIASGKAGFDLAG 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999  157 ANMLSDG--------YNVGVGVGAEIIGTFVLVYTVFSATDPKRNARdshipvLAPLPIGFSVFMVHLATIPITGTGINP 228
Cdd:PRK05420 114 SGFASNGygehspggYSLLAALVCEVVLTAFFLLVILGATDKRAPAG------FAPIAIGLALTLIHLISIPVTNTSVNP 187

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 15224999  229 ARSFGAAVIYNNQkAWDDQWIFWVGPFVGAAIAAFYHQFVLRAGA 273
Cdd:PRK05420 188 ARSTGVALFVGGW-ALEQLWLFWVAPIVGAIIGGLIYRLLLEKDD 231
PLN00167 PLN00167
aquaporin TIP5; Provisional
 38-269 1.31e-27

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 107.30  E-value: 1.31e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999   38 RAVIAEFIATLLFlyvtVLTVIGFKSQTDINAGGGACASVGLLGISWAFGGMIFILVYCTAGISGGHINPAVTFGLFLAS 117
Cdd:PLN00167  23 RSYLAEFISTFFF----VFAAVGSAMSSRKLMPDAASDPSSLLIVAIANAFALSSAVYIAANISGGHVNPAVTFGMAVGG 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999  118 KVSLVRAVSYMVAQCLGATCGVGLVKVFQ-STYYNRYGGGANMLSDGYNVGVGVgaeiiGTFVLVYTVFSATDPKRnard 196
Cdd:PLN00167  99 HISVPTAMFYWISQMLASVMACLFLKVTTvGQHVPTYKIAEEMTGFGASVLEGV-----LTFGLVYTVYAAGDPRR---- 169

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15224999  197 SHIPVLAPLPIGFSVFMVHLATIPITGTGINPARSFGAAVIYNNQKawdDQWIFWVGPFVGAAIAAFYHQFVL 269
Cdd:PLN00167 170 GLLGAIGPLAIGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSFK---NQAVYWVGPLLGGAVAGLLYDNVV 239
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 19-269 2.26e-21

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 91.34  E-value: 2.26e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999   19 DPPPVKTFEVRELKKWsfYRAVIAEFIATLLFLYVTVLTVIGFksQTDINAGGGACASVGllgisWAFGgmIFILVYCTA 98
Cdd:PTZ00016  34 PPGGQNFWAPREYRPN--VREYVAEFLGTFVLLFFGEGVVATT--HTVGNNGDYLAITIG-----WGLG--VTFGLLVSA 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999   99 GISGGHINPAVTFGLFLASKVSLVRAVSYMVAQCLGATCGVGLVKVFQSTYYNRYGGG--ANMLSDGYNVGV-------- 168
Cdd:PTZ00016 103 GISGGHLNPAVTLGNAVFGKFPWKKLPGYFVAQLLGAFVGAACVYGLYYGFFKDHGIPelPWETMANGFAGVfatypreg 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999  169 ---GVGAEIIGTFVLVYTVFSATDPKRNARDSHIPVlaplPIGFSVFMVHLATIPITGTGINPARSFGA----AVIYNNQ 241
Cdd:PTZ00016 183 nfyAIFSELILTAILLLVILAITDPNNCPAFNYLPV----AVGLLVFVIGISFGGNTGYALNPARDLGPrlfsAILWGSE 258

                        250       260       270
                 ....*....|....*....|....*....|.
gi 15224999  242 KAWDDQWIFW---VGPFVGAAIAAFYHQFVL 269
Cdd:PTZ00016 259 VFTKDNYYFWvplVAPFVGAVLGMFLYDKFI 289
PLN00184 PLN00184
aquaporin NIP1; Provisional
 3-268 4.80e-20

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 87.77  E-value: 4.80e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999    3 KDELTEEESLsgKDYLDPPPVKTFEVRELKKWSFYRAVIAEFIATLlFLYVTVLTVIGFKSQTDinagggacASVGLLGI 82
Cdd:PLN00184  22 KEEVEHQQEM--EAIHNPKPLKKQDSLLSVSVPFLQKLIAEVLGTY-FLVFTGCASVVVNMQND--------NVVTLPGI 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999   83 SWAFGGMIFILVYCTAGISGGHINPAVTFGLFLASKVSLVRAVSYMVAQCLGATCGVGLVKVFQSTYYNRYGGGANMLSD 162
Cdd:PLN00184  91 AIVWGLTIMVLIYSLGHISGAHINPAVTIAFASCGRFPLKQVPAYVISQVIGSTLAAATLRLLFGLDHDVCSGKHDVFIG 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999  163 GYNVGVGVGA---EIIGTFVLVYTVFS-ATDpkrnarDSHIPVLAPLPIGFSVFMVHLATIPITGTGINPARSFGAAVIY 238
Cdd:PLN00184 171 SSPVGSDLQAfvmEFIVTFYLMFIISGvATD------NRAIGELAGLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVY 244

                        250       260       270
                 ....*....|....*....|....*....|
gi 15224999  239 NNQKAWddqWIFWVGPFVGAAIAAFYHQFV 268
Cdd:PLN00184 245 GCYKGI---WIYIVAPTLGAIAGAWVYNTV 271
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 38-270 2.85e-19

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 85.29  E-value: 2.85e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999   38 RAVIAEFIATLLFLYvtvlTVIGFKSQTDINAGggacaSVGLLGISWAFGGMIFILVYCTAGISGGHINPAVT-----FG 112
Cdd:PLN00183  46 RMVLAEMVGTFILMF----CVCGIIASTQLSGG-----EVGLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTiafatFG 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999  113 LFLASKVSLvravsYMVAQCLGATCgvglvkvfqSTYYNR--YGGGANMLSDGYNVGVGVG--AEIIGTFVLVYTVFSAT 188
Cdd:PLN00183 117 HFPWSKVPL-----YITAQTVGSVL---------ATYVGVsvYGVKADLMTTKPAQGCSSAfwVEFIATFIVMFLAASLT 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999  189 DPKRNARDshipvLAPLPIGFSVFMVHLATIPITGTGINPARSFGAAVIynnqkAWD--DQWIFWVGPFVGAAIAAF-YH 265
Cdd:PLN00183 183 SQPQSLGH-----LSGFVIGIAIGLAVLITGPVSGGSMNPARSLGPAIV-----SWDfkDIWIYITAPTIGAVAGALmFH 252


                 ....*
gi 15224999  266 QFVLR 270
Cdd:PLN00183 253 LLRLR 257
PLN00026 PLN00026
aquaporin NIP; Provisional
 18-262 2.50e-15

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 74.51  E-value: 2.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999   18 LDPPPVktfevrelkkwSFYRAVIAEFIATLLFLYVTVLTVIGFKSQTDINAGGGACASVGLlgiswafGGMIFILvyCT 97
Cdd:PLN00026  63 LPPPDV-----------SLTRKLGAEFVGTFILIFAATAGPIVNQKYDGAETLIGNAACAGL-------AVMIVIL--ST 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999   98 AGISGGHINPAVTFGLFLASKVSLVRAVSYMVAQCLGATC-GVGLVKVFQSTyynrYGGGANMLSDGYnvGVGVGAEIIG 176
Cdd:PLN00026 123 GHISGAHLNPSLTIAFAALRHFPWKHVPAYIAAQVSASICaSFALKGVFHPF----MSGGVTVPSVST--GQAFALEFII 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999  177 TFVLVYTVFS-ATDPKRnardshIPVLAPLPIGFSVFMVHLATIPITGTGINPARSFGAAVIYNNQKAWddqWIFWVGPF 255
Cdd:PLN00026 197 TFNLLFVVTAvATDTRA------VGELAGIAVGATVMLNILVAGPSTGGSMNPVRTLGPAVAAGNYRAI---WIYLVAPT 267


                 ....*..
gi 15224999  256 VGAAIAA 262
Cdd:PLN00026 268 LGALAGA 274
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 40-268 8.31e-15

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 73.02  E-value: 8.31e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999   40 VIAEFIATllflYVTVLTVIGFKSQTDINAGggacaSVGLLGISWAFGGMIFILVYCTAGISGGHINPAVTFGLFLASKV 119
Cdd:PLN00182  45 LIAEMIGT----YFIIFSGCGVVVVNVLYGG-----TITFPGICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRF 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15224999  120 SLVRAVSYMVAQCLGATCGVGLVKVFQSTYYNRYGGGANMLSDGYnvgvGVGAEIIGTFVLVYTVFSATDPKRNARDshi 199
Cdd:PLN00182 116 PWYQVPLYIGAQLTGSLLASLTLRLMFNVTPEAFFGTTPTDSSGQ----ALVAEIIISFLLMFVISGVATDSRAVGE--- 188

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15224999  200 pvLAPLPIGFSVFMVHLATIPITGTGINPARSFGAAVIYNNQKAWddqWIFWVGPFVGAAIAAFYHQFV 268
Cdd:PLN00182 189 --LAGIAVGMTIILNVFVAGPISGASMNPARSLGPAIVMGRYKGI---WVYIVGPFVGIIAGGFVYNLI 252
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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