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Conserved domains on  [gi|42565068|ref|NP_188743|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
24-363 1.87e-24

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.76  E-value: 1.87e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068  24 GVIKCVAFNHRGSLLAAGCADGGCVIWDFETRGIAKEIRDNdcSAAITSVSWSKYGHRLLVSAADKSLTLWDVSTGEKIa 103
Cdd:COG2319 121 GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGH--SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLL- 197

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068 104 RTIlqqtplqarlnPGLSSPSLCLAcplssapmivdfdidcttllpvsvpempdvlappqrskcpesnppFSPAaacfnk 183
Cdd:COG2319 198 RTL-----------TGHTGAVRSVA---------------------------------------------FSPD------ 215

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068 184 cGDLVYIGNSKGEILIVDYKSVRVLALVSASGAaPVKNIVFSRNGQYLLTNSHDRTIRIYEnllpaknvlksledlgkni 263
Cdd:COG2319 216 -GKLLASGSADGTVRLWDLATGKLLRTLTGHSG-SVRSVAFSPDGRLLASGSADGTVRLWD------------------- 274

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068 264 dgldgiekmkTVGSKCLTLFREFQDSVTKMhwkapCFSGDGEWVVGGSAckgEHKIYIWDRA-GHLVKILEGPKEALIDL 342
Cdd:COG2319 275 ----------LATGELLRTLTGHSGGVNSV-----AFSPDGKLLASGSD---DGTVRLWDLAtGKLLRTLTGHTGAVRSV 336

                       330       340
                ....*....|....*....|.
gi 42565068 343 AWHPVHPIIVSVSLAGLVYIW 363
Cdd:COG2319 337 AFSPDGKTLASGSDDGTVRLW 357
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
24-363 1.87e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.76  E-value: 1.87e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068  24 GVIKCVAFNHRGSLLAAGCADGGCVIWDFETRGIAKEIRDNdcSAAITSVSWSKYGHRLLVSAADKSLTLWDVSTGEKIa 103
Cdd:COG2319 121 GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGH--SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLL- 197

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068 104 RTIlqqtplqarlnPGLSSPSLCLAcplssapmivdfdidcttllpvsvpempdvlappqrskcpesnppFSPAaacfnk 183
Cdd:COG2319 198 RTL-----------TGHTGAVRSVA---------------------------------------------FSPD------ 215

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068 184 cGDLVYIGNSKGEILIVDYKSVRVLALVSASGAaPVKNIVFSRNGQYLLTNSHDRTIRIYEnllpaknvlksledlgkni 263
Cdd:COG2319 216 -GKLLASGSADGTVRLWDLATGKLLRTLTGHSG-SVRSVAFSPDGRLLASGSADGTVRLWD------------------- 274

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068 264 dgldgiekmkTVGSKCLTLFREFQDSVTKMhwkapCFSGDGEWVVGGSAckgEHKIYIWDRA-GHLVKILEGPKEALIDL 342
Cdd:COG2319 275 ----------LATGELLRTLTGHSGGVNSV-----AFSPDGKLLASGSD---DGTVRLWDLAtGKLLRTLTGHTGAVRSV 336

                       330       340
                ....*....|....*....|.
gi 42565068 343 AWHPVHPIIVSVSLAGLVYIW 363
Cdd:COG2319 337 AFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 24-364 1.77e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.49  E-value: 1.77e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068  24 GVIKCVAFNHRGSLLAAGCADGGCVIWDFETRgiAKEIRDNDCSAAITSVSWSKYGHRLLVSAADKSLTLWDVSTGEKIa 103
Cdd:cd00200  10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETG--ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECV- 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068 104 RTIL--QQTPLQARLNPglsSPSLCLACplSSAPMIVDFDIDCTTLLPVsvpeMPDVLAPPQrskcpesnppfspaAACF 181
Cdd:cd00200  87 RTLTghTSYVSSVAFSP---DGRILSSS--SRDKTIKVWDVETGKCLTT----LRGHTDWVN--------------SVAF 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068 182 NKCGDLVYIGNSKGEILIVDYKSVRVLALVSASgAAPVKNIVFSRNGQYLLTNSHDRTIRIYEnllpaknvlksledlgk 261
Cdd:cd00200 144 SPDGTFVASSSQDGTIKLWDLRTGKCVATLTGH-TGEVNSVAFSPDGEKLLSSSSDGTIKLWD----------------- 205

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068 262 nidgldgiekmkTVGSKCLTLFREFQDSVTkmhwkAPCFSGDGEWVVGGSAckgEHKIYIWD-RAGHLVKILEGPKEALI 340
Cdd:cd00200 206 ------------LSTGKCLGTLRGHENGVN-----SVAFSPDGYLLASGSE---DGTIRVWDlRTGECVQTLSGHTNSVT 265

                       330       340
                ....*....|....*....|....
gi 42565068 341 DLAWHPVHPIIVSVSLAGLVYIWA 364
Cdd:cd00200 266 SLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 15-51 3.77e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 3.77e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 42565068     15 EVIEEYLEH-GVIKCVAFNHRGSLLAAGCADGGCVIWD 51
Cdd:smart00320   3 ELLKTLKGHtGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 26-76 1.04e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.41  E-value: 1.04e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 42565068    26 IKCVAFNHRGSLLAAGCADGGCVIWDFETrgiAKEIRDNDC-SAAITSVSWS 76
Cdd:pfam12894  41 VTSLAWRPDGKLLAVGYSDGTVRLLDAEN---GKIVHHFSAgSDLITCLGWG 89
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
24-363 1.87e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.76  E-value: 1.87e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068  24 GVIKCVAFNHRGSLLAAGCADGGCVIWDFETRGIAKEIRDNdcSAAITSVSWSKYGHRLLVSAADKSLTLWDVSTGEKIa 103
Cdd:COG2319 121 GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGH--SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLL- 197

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068 104 RTIlqqtplqarlnPGLSSPSLCLAcplssapmivdfdidcttllpvsvpempdvlappqrskcpesnppFSPAaacfnk 183
Cdd:COG2319 198 RTL-----------TGHTGAVRSVA---------------------------------------------FSPD------ 215

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068 184 cGDLVYIGNSKGEILIVDYKSVRVLALVSASGAaPVKNIVFSRNGQYLLTNSHDRTIRIYEnllpaknvlksledlgkni 263
Cdd:COG2319 216 -GKLLASGSADGTVRLWDLATGKLLRTLTGHSG-SVRSVAFSPDGRLLASGSADGTVRLWD------------------- 274

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068 264 dgldgiekmkTVGSKCLTLFREFQDSVTKMhwkapCFSGDGEWVVGGSAckgEHKIYIWDRA-GHLVKILEGPKEALIDL 342
Cdd:COG2319 275 ----------LATGELLRTLTGHSGGVNSV-----AFSPDGKLLASGSD---DGTVRLWDLAtGKLLRTLTGHTGAVRSV 336

                       330       340
                ....*....|....*....|.
gi 42565068 343 AWHPVHPIIVSVSLAGLVYIW 363
Cdd:COG2319 337 AFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 24-364 1.77e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.49  E-value: 1.77e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068  24 GVIKCVAFNHRGSLLAAGCADGGCVIWDFETRgiAKEIRDNDCSAAITSVSWSKYGHRLLVSAADKSLTLWDVSTGEKIa 103
Cdd:cd00200  10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETG--ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECV- 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068 104 RTIL--QQTPLQARLNPglsSPSLCLACplSSAPMIVDFDIDCTTLLPVsvpeMPDVLAPPQrskcpesnppfspaAACF 181
Cdd:cd00200  87 RTLTghTSYVSSVAFSP---DGRILSSS--SRDKTIKVWDVETGKCLTT----LRGHTDWVN--------------SVAF 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068 182 NKCGDLVYIGNSKGEILIVDYKSVRVLALVSASgAAPVKNIVFSRNGQYLLTNSHDRTIRIYEnllpaknvlksledlgk 261
Cdd:cd00200 144 SPDGTFVASSSQDGTIKLWDLRTGKCVATLTGH-TGEVNSVAFSPDGEKLLSSSSDGTIKLWD----------------- 205

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068 262 nidgldgiekmkTVGSKCLTLFREFQDSVTkmhwkAPCFSGDGEWVVGGSAckgEHKIYIWD-RAGHLVKILEGPKEALI 340
Cdd:cd00200 206 ------------LSTGKCLGTLRGHENGVN-----SVAFSPDGYLLASGSE---DGTIRVWDlRTGECVQTLSGHTNSVT 265

                       330       340
                ....*....|....*....|....
gi 42565068 341 DLAWHPVHPIIVSVSLAGLVYIWA 364
Cdd:cd00200 266 SLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
23-363 7.06e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.76  E-value: 7.06e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068  23 HGVIKCVAFNHRGSLLAAGCADGGCVIWDFETRGIAKEIRDNdcSAAITSVSWSKYGHRLLVSAADKSLTLWDVSTGEKI 102
Cdd:COG2319 162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH--TGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL 239

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068 103 ARTilqqtplqarlnPGLSSPSLCLAcplssapmivdfdidcttllpvsvpempdvlappqrskcpesnppFSPAaacfn 182
Cdd:COG2319 240 RTL------------TGHSGSVRSVA---------------------------------------------FSPD----- 257

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068 183 kcGDLVYIGNSKGEILIVDYKSVRVLALVSAsGAAPVKNIVFSRNGQYLLTNSHDRTIRIYenllpaknvlksleDLGKN 262
Cdd:COG2319 258 --GRLLASGSADGTVRLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGSDDGTVRLW--------------DLATG 320

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068 263 idgldgiekmktvgsKCLTLFREFQDSVTKMhwkapCFSGDGEWVVGGSAckgEHKIYIWDRA-GHLVKILEGPKEALID 341
Cdd:COG2319 321 ---------------KLLRTLTGHTGAVRSV-----AFSPDGKTLASGSD---DGTVRLWDLAtGELLRTLTGHTGAVTS 377

                       330       340
                ....*....|....*....|..
gi 42565068 342 LAWHPVHPIIVSVSLAGLVYIW 363
Cdd:COG2319 378 VAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
15-326 9.20e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.43  E-value: 9.20e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068  15 EVIEEYLEH-GVIKCVAFNHRGSLLAAGCADGGCVIWDFETRGIAKEIRDNdcSAAITSVSWSKYGHRLLVSAADKSLTL 93
Cdd:COG2319 195 KLLRTLTGHtGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGH--SGSVRSVAFSPDGRLLASGSADGTVRL 272

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068  94 WDVSTGEKIartilqqtplqaRLNPGLSSPSLCLAcplssapmivdfdidcttllpvsvpempdvlappqrskcpesnpp 173
Cdd:COG2319 273 WDLATGELL------------RTLTGHSGGVNSVA--------------------------------------------- 295

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068 174 FSPAaacfnkcGDLVYIGNSKGEILIVDYKSVRVLALVSASGaAPVKNIVFSRNGQYLLTNSHDRTIRIYEnllpaknvl 253
Cdd:COG2319 296 FSPD-------GKLLASGSDDGTVRLWDLATGKLLRTLTGHT-GAVRSVAFSPDGKTLASGSDDGTVRLWD--------- 358

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 42565068 254 ksledlgknidgldgiekmkTVGSKCLTLFREFQDSVTKMhwkapCFSGDGEWVVGGSAckgEHKIYIWDRAG 326
Cdd:COG2319 359 --------------------LATGELLRTLTGHTGAVTSV-----AFSPDGRTLASGSA---DGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
175-363 2.09e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.78  E-value: 2.09e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068 175 SPAAACFNKCGDLVYIGNSKGEILIVDYKSVRVLALVSASGAaPVKNIVFSRNGQYLLTNSHDRTIRIYEnlLPAKNVLK 254
Cdd:COG2319  80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG-AVRSVAFSPDGKTLASGSADGTVRLWD--LATGKLLR 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068 255 SLEDLGKNIDGL----DGieKM-------KTV------GSKCLTLFREFQDSVTkmhwkAPCFSGDGEWVVGGSAckgEH 317
Cdd:COG2319 157 TLTGHSGAVTSVafspDG--KLlasgsddGTVrlwdlaTGKLLRTLTGHTGAVR-----SVAFSPDGKLLASGSA---DG 226

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 42565068 318 KIYIWDRA-GHLVKILEGPKEALIDLAWHPVHPIIVSVSLAGLVYIW 363
Cdd:COG2319 227 TVRLWDLAtGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
206-363 2.94e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.15  E-value: 2.94e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068 206 RVLALVSASGAAPVKNIVFSRNGQYLLTNSHDRTIRIYEnllpaknvlksledlgknidgldgiekmkTVGSKCLTLFRE 285
Cdd:COG2319  68 GALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWD-----------------------------LATGLLLRTLTG 118

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42565068 286 FQDSVTkmhwkAPCFSGDGEWVVGGSAckgEHKIYIWDRA-GHLVKILEGPKEALIDLAWHPVHPIIVSVSLAGLVYIW 363
Cdd:COG2319 119 HTGAVR-----SVAFSPDGKTLASGSA---DGTVRLWDLAtGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-103 4.17e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.49  E-value: 4.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565068  15 EVIEEYLEH-GVIKCVAFNHRGSLLAAGCADGGCVIWDFETRGIAKEIRDNDcsAAITSVSWSKYGHRLLVSAADKSLTL 93
Cdd:cd00200 168 KCVATLTGHtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHE--NGVNSVAFSPDGYLLASGSEDGTIRV 245

                        90
                ....*....|
gi 42565068  94 WDVSTGEKIA 103
Cdd:cd00200 246 WDLRTGECVQ 255
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 15-51 3.77e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 3.77e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 42565068     15 EVIEEYLEH-GVIKCVAFNHRGSLLAAGCADGGCVIWD 51
Cdd:smart00320   3 ELLKTLKGHtGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 26-76 1.04e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.41  E-value: 1.04e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 42565068    26 IKCVAFNHRGSLLAAGCADGGCVIWDFETrgiAKEIRDNDC-SAAITSVSWS 76
Cdd:pfam12894  41 VTSLAWRPDGKLLAVGYSDGTVRLLDAEN---GKIVHHFSAgSDLITCLGWG 89
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 326-363 1.20e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.20e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 42565068    326 GHLVKILEGPKEALIDLAWHPVHPIIVSVSLAGLVYIW 363
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
15-51 1.76e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.76e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 42565068    15 EVIEEYLEH-GVIKCVAFNHRGSLLAAGCADGGCVIWD 51
Cdd:pfam00400   2 KLLKTLEGHtGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 67-95 3.26e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 3.26e-03
                           10        20
                   ....*....|....*....|....*....
gi 42565068     67 SAAITSVSWSKYGHRLLVSAADKSLTLWD 95
Cdd:smart00320  12 TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 217-244 6.06e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 6.06e-03
                           10        20
                   ....*....|....*....|....*...
gi 42565068    217 APVKNIVFSRNGQYLLTNSHDRTIRIYE 244
Cdd:smart00320  13 GPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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