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Conserved domains on  [gi|30681950|ref|NP_192929|]
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cell cycle switch protein 52 A2 [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
181-451 3.78e-40

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 148.91  E-value: 3.78e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 181 VLAVGLGNCVYLWNAcSSKVTKLCDLGVDETVCSVGWALRGTHLAIGTSSGTVQIWDVLRCKNIRTMEGHRLRVGALAWS 260
Cdd:COG2319  93 LASASADGTVRLWDL-ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS 171

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 261 SSVLS--SGSRDKSILQRDIRTQEdHVSKLKGHKSEICGLKWSSDNRELASGGNDNKLFVWNQHSTQPVLRFCEHAAAVK 338
Cdd:COG2319 172 PDGKLlaSGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVR 250

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 339 AIAWSPHhfG-LLASGGgtADRCIRFWNTTTNTHLNCVDT-NSQVCNLVWSKNVNELVSthGYSQNQIIVWKYPTMSKLA 416
Cdd:COG2319 251 SVAFSPD--GrLLASGS--ADGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLLR 324

                       250       260       270
                ....*....|....*....|....*....|....*
gi 30681950 417 TLTGHSYRVLYLAVSPDGQTIVTGAGDETLRFWNV 451
Cdd:COG2319 325 TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
181-451 3.78e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 148.91  E-value: 3.78e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 181 VLAVGLGNCVYLWNAcSSKVTKLCDLGVDETVCSVGWALRGTHLAIGTSSGTVQIWDVLRCKNIRTMEGHRLRVGALAWS 260
Cdd:COG2319  93 LASASADGTVRLWDL-ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS 171

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 261 SSVLS--SGSRDKSILQRDIRTQEdHVSKLKGHKSEICGLKWSSDNRELASGGNDNKLFVWNQHSTQPVLRFCEHAAAVK 338
Cdd:COG2319 172 PDGKLlaSGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVR 250

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 339 AIAWSPHhfG-LLASGGgtADRCIRFWNTTTNTHLNCVDT-NSQVCNLVWSKNVNELVSthGYSQNQIIVWKYPTMSKLA 416
Cdd:COG2319 251 SVAFSPD--GrLLASGS--ADGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLLR 324

                       250       260       270
                ....*....|....*....|....*....|....*
gi 30681950 417 TLTGHSYRVLYLAVSPDGQTIVTGAGDETLRFWNV 451
Cdd:COG2319 325 TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 212-451 2.27e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 127.45  E-value: 2.27e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 212 VCSVGWALRGTHLAIGTSSGTVQIWDVLRCKNIRTMEGHRLRVGALAWSSSVLS--SGSRDKSILQRDIRTQEDhVSKLK 289
Cdd:cd00200  12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYlaSGSSDKTIRLWDLETGEC-VRTLT 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 290 GHKSEICGLKWSSDNRELASGGNDNKLFVWNQHSTQPVLRFCEHAAAVKAIAWSPhhFGLLASGGGtADRCIRFWNTTTN 369
Cdd:cd00200  91 GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP--DGTFVASSS-QDGTIKLWDLRTG 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 370 ThlnCVDT----NSQVCNLVWSKNVNELVSthGYSQNQIIVWKYPTMSKLATLTGHSYRVLYLAVSPDGQTIVTGAGDET 445
Cdd:cd00200 168 K---CVATltghTGEVNSVAFSPDGEKLLS--SSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGT 242


                ....*.
gi 30681950 446 LRFWNV 451
Cdd:cd00200 243 IRVWDL 248
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 292-451 7.25e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 55.09  E-value: 7.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950  292 KSEICGLKWSSD-NRELASGGNDNKLFVWNQHSTQPVLRFCEHAAAVKAIAWSPHHFGLLASggGTADRCIRFWNTTTNT 370
Cdd:PLN00181 532 RSKLSGICWNSYiKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLAS--GSDDGSVKLWSINQGV 609

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950  371 HLNCVDTNSQVCNLVWSKNVNELVStHGYSQNQIIVW--KYPTMSkLATLTGHSYRVLYLAVSpDGQTIVTGAGDETLRF 448
Cdd:PLN00181 610 SIGTIKTKANICCVQFPSESGRSLA-FGSADHKVYYYdlRNPKLP-LCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKL 686


                 ...
gi 30681950  449 WNV 451
Cdd:PLN00181 687 WDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 411-450 1.39e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.39e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 30681950    411 TMSKLATLTGHSYRVLYLAVSPDGQTIVTGAGDETLRFWN 450
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
412-450 1.25e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.25e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 30681950   412 MSKLATLTGHSYRVLYLAVSPDGQTIVTGAGDETLRFWN 450
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
181-451 3.78e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 148.91  E-value: 3.78e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 181 VLAVGLGNCVYLWNAcSSKVTKLCDLGVDETVCSVGWALRGTHLAIGTSSGTVQIWDVLRCKNIRTMEGHRLRVGALAWS 260
Cdd:COG2319  93 LASASADGTVRLWDL-ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS 171

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 261 SSVLS--SGSRDKSILQRDIRTQEdHVSKLKGHKSEICGLKWSSDNRELASGGNDNKLFVWNQHSTQPVLRFCEHAAAVK 338
Cdd:COG2319 172 PDGKLlaSGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVR 250

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 339 AIAWSPHhfG-LLASGGgtADRCIRFWNTTTNTHLNCVDT-NSQVCNLVWSKNVNELVSthGYSQNQIIVWKYPTMSKLA 416
Cdd:COG2319 251 SVAFSPD--GrLLASGS--ADGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLLR 324

                       250       260       270
                ....*....|....*....|....*....|....*
gi 30681950 417 TLTGHSYRVLYLAVSPDGQTIVTGAGDETLRFWNV 451
Cdd:COG2319 325 TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
174-451 3.99e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.21  E-value: 3.99e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 174 VDWSA--QNVLAVGLGNCVYLWNACSSKVtkLCDL-GVDETVCSVGWALRGTHLAIGTSSGTVQIWDVLRCKNIRTMEGH 250
Cdd:COG2319 126 VAFSPdgKTLASGSADGTVRLWDLATGKL--LRTLtGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH 203

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 251 RLRVGALAWSSSVLS--SGSRDKSILQRDIRTQEdHVSKLKGHKSEICGLKWSSDNRELASGGNDNKLFVWNQHSTQPVL 328
Cdd:COG2319 204 TGAVRSVAFSPDGKLlaSGSADGTVRLWDLATGK-LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR 282

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 329 RFCEHAAAVKAIAWSPHhfG-LLASGGgtADRCIRFWNTTTNTHLNCVDTNS-QVCNLVWSKNVNELVSthGYSQNQIIV 406
Cdd:COG2319 283 TLTGHSGGVNSVAFSPD--GkLLASGS--DDGTVRLWDLATGKLLRTLTGHTgAVRSVAFSPDGKTLAS--GSDDGTVRL 356

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 30681950 407 WKYPTMSKLATLTGHSYRVLYLAVSPDGQTIVTGAGDETLRFWNV 451
Cdd:COG2319 357 WDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
206-451 4.65e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 140.43  E-value: 4.65e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 206 LGVDETVCSVGWALRGTHLAIGTSSGTVQIWDVLRCKNIRTMEGHRLRVGALAWSSSVLS--SGSRDKSILQRDIRTQEd 283
Cdd:COG2319  75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTlaSGSADGTVRLWDLATGK- 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 284 HVSKLKGHKSEICGLKWSSDNRELASGGNDNKLFVWNQHSTQPVLRFCEHAAAVKAIAWSPHHfGLLASGGgtADRCIRF 363
Cdd:COG2319 154 LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-KLLASGS--ADGTVRL 230

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 364 WNTTTNTHLNCVDT-NSQVCNLVWSKNVNELVSthGYSQNQIIVWKYPTMSKLATLTGHSYRVLYLAVSPDGQTIVTGAG 442
Cdd:COG2319 231 WDLATGKLLRTLTGhSGSVRSVAFSPDGRLLAS--GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSD 308


                ....*....
gi 30681950 443 DETLRFWNV 451
Cdd:COG2319 309 DGTVRLWDL 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 212-451 2.27e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 127.45  E-value: 2.27e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 212 VCSVGWALRGTHLAIGTSSGTVQIWDVLRCKNIRTMEGHRLRVGALAWSSSVLS--SGSRDKSILQRDIRTQEDhVSKLK 289
Cdd:cd00200  12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYlaSGSSDKTIRLWDLETGEC-VRTLT 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 290 GHKSEICGLKWSSDNRELASGGNDNKLFVWNQHSTQPVLRFCEHAAAVKAIAWSPhhFGLLASGGGtADRCIRFWNTTTN 369
Cdd:cd00200  91 GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP--DGTFVASSS-QDGTIKLWDLRTG 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 370 ThlnCVDT----NSQVCNLVWSKNVNELVSthGYSQNQIIVWKYPTMSKLATLTGHSYRVLYLAVSPDGQTIVTGAGDET 445
Cdd:cd00200 168 K---CVATltghTGEVNSVAFSPDGEKLLS--SSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGT 242


                ....*.
gi 30681950 446 LRFWNV 451
Cdd:cd00200 243 IRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
214-451 7.01e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.18  E-value: 7.01e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 214 SVGWALRGTHLAIGTSSGTVQIWDVLRCKNIRTMEGHRLRVGALAWSSSVLS--SGSRDKSILQRDIRTQEdHVSKLKGH 291
Cdd:COG2319  41 SLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLlaSASADGTVRLWDLATGL-LLRTLTGH 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 292 KSEICGLKWSSDNRELASGGNDNKLFVWNQHSTQPVLRFCEHAAAVKAIAWSPHhfG-LLASGGgtADRCIRFWNTTTNT 370
Cdd:COG2319 120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD--GkLLASGS--DDGTVRLWDLATGK 195

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 371 HLNCVD-TNSQVCNLVWSKNVNELVSthGYSQNQIIVWKYPTMSKLATLTGHSYRVLYLAVSPDGQTIVTGAGDETLRFW 449
Cdd:COG2319 196 LLRTLTgHTGAVRSVAFSPDGKLLAS--GSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273


                ..
gi 30681950 450 NV 451
Cdd:COG2319 274 DL 275
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 174-450 8.35e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.21  E-value: 8.35e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 174 VDWSAQ-NVLAVGLG-NCVYLWNACSSKVtKLCDLGVDETVCSVGWALRGTHLAIGTSSGTVQIWDVLRCKNIRTMEGHR 251
Cdd:cd00200  15 VAFSPDgKLLATGSGdGTIKVWDLETGEL-LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHT 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 252 LRVGALAWSSSVL--SSGSRDKSILQRDIRTqEDHVSKLKGHKSEICGLKWSSDNRELASGGNDNKLFVWNQHSTQPVLR 329
Cdd:cd00200  94 SYVSSVAFSPDGRilSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 330 FCEHAAAVKAIAWSPHHFGLLASGGgtaDRCIRFWNTTTNTHLN-CVDTNSQVCNLVWSKNVNELVSthGYSQNQIIVWK 408
Cdd:cd00200 173 LTGHTGEVNSVAFSPDGEKLLSSSS---DGTIKLWDLSTGKCLGtLRGHENGVNSVAFSPDGYLLAS--GSEDGTIRVWD 247

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 30681950 409 YPTMSKLATLTGHSYRVLYLAVSPDGQTIVTGAGDETLRFWN 450
Cdd:cd00200 248 LRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 243-451 6.10e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 115.51  E-value: 6.10e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 243 NIRTMEGHRLRVGALAWSSSVLS--SGSRDKSILQRDIRTQEdHVSKLKGHKSEICGLKWSSDNRELASGGNDNKLFVWN 320
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLlaTGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 321 QHSTQPVLRFCEHAAAVKAIAWSPHHFgLLASGGgtADRCIRFWNTTTNTHLNCVDT-NSQVCNLVWSKNvNELVSThGY 399
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSS--RDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSPD-GTFVAS-SS 154

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 30681950 400 SQNQIIVWKYPTMSKLATLTGHSYRVLYLAVSPDGQTIVTGAGDETLRFWNV 451
Cdd:cd00200 155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL 206
WD40 COG2319
WD40 repeat [General function prediction only];
216-451 6.34e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.23  E-value: 6.34e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 216 GWALRGTHLAIGTSSGTVQIWDVLRCKNIRTMEGHRLRVGALAWSSSVLSSGSRDKSILQRDIRTQEDHVSK-LKGHKSE 294
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLAtLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950 295 ICGLKWSSDNRELASGGNDNKLFVWNQHSTQPVLRFCEHAAAVKAIAWSPHHfGLLASGGgtADRCIRFWNTTTNTHLNC 374
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDG-KTLASGS--ADGTVRLWDLATGKLLRT 157

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30681950 375 VDTNSQ-VCNLVWSKNVNELVSthGYSQNQIIVWKYPTMSKLATLTGHSYRVLYLAVSPDGQTIVTGAGDETLRFWNV 451
Cdd:COG2319 158 LTGHSGaVTSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 292-451 7.25e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 55.09  E-value: 7.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950  292 KSEICGLKWSSD-NRELASGGNDNKLFVWNQHSTQPVLRFCEHAAAVKAIAWSPHHFGLLASggGTADRCIRFWNTTTNT 370
Cdd:PLN00181 532 RSKLSGICWNSYiKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLAS--GSDDGSVKLWSINQGV 609

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950  371 HLNCVDTNSQVCNLVWSKNVNELVStHGYSQNQIIVW--KYPTMSkLATLTGHSYRVLYLAVSpDGQTIVTGAGDETLRF 448
Cdd:PLN00181 610 SIGTIKTKANICCVQFPSESGRSLA-FGSADHKVYYYdlRNPKLP-LCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKL 686


                 ...
gi 30681950  449 WNV 451
Cdd:PLN00181 687 WDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 411-450 1.39e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.39e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 30681950    411 TMSKLATLTGHSYRVLYLAVSPDGQTIVTGAGDETLRFWN 450
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 285-320 2.06e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.06e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 30681950    285 VSKLKGHKSEICGLKWSSDNRELASGGNDNKLFVWN 320
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
412-450 1.25e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.25e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 30681950   412 MSKLATLTGHSYRVLYLAVSPDGQTIVTGAGDETLRFWN 450
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
285-320 2.61e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.61e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 30681950   285 VSKLKGHKSEICGLKWSSDNRELASGGNDNKLFVWN 320
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 222-455 2.36e-03

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 40.46  E-value: 2.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950  222 THLAIGTSSGTVQIWDVLRCKNIRTMEGHRLRVGALAWSSSVLS--SGSRDKSILQRDIRTQEDHVSKLKGhKSEICGLK 299
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTllASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQ 624

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681950  300 WSSDN-RELASGGNDNKLFVWNQHStqPVLRFCEHAAAVKAIAWsphhfgllasgggtadrcIRFWNTTTNTHlNCVDTN 378
Cdd:PLN00181 625 FPSESgRSLAFGSADHKVYYYDLRN--PKLPLCTMIGHSKTVSY------------------VRFVDSSTLVS-SSTDNT 683

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30681950  379 SQVCNLVWS-KNVNElvsthgysqnqiivwkyptmSKLATLTGHSYRVLYLAVSPDGQTIVTGA-GDETLRFWNVFPSP 455
Cdd:PLN00181 684 LKLWDLSMSiSGINE--------------------TPLHSFMGHTNVKNFVGLSVSDGYIATGSeTNEVFVYHKAFPMP 742
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 323-365 4.03e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 4.03e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 30681950    323 STQPVLRFCEHAAAVKAIAWSPHHfGLLASGGgtADRCIRFWN 365
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDG-KYLASGS--DDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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