|
Name |
Accession |
Description |
Interval |
E-value |
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
53-261 |
3.68e-101 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 306.05 E-value: 3.68e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 53 LDSRLIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLFSADSVSKKKLAPSAFILVPSREL 132
Cdd:cd17961 1 LDPRLLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKAKAESGEEQGTRALILVPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 133 CQQVYTEVSSLIELCRVQLKAVQLTSSMSASDMRNALAGLPEILVSTPACIPKCFAAGVLEptaVSESLSILVLDEADLL 212
Cdd:cd17961 81 AQQVSKVLEQLTAYCRKDVRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLSHLESGSLL---LLSTLKYLVIDEADLV 157
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 15236218 213 LSYGYEDNLRSVTSIIPRRCQCLLMSATTSSDVEKLKKLILHNPIVLTL 261
Cdd:cd17961 158 LSYGYEEDLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPAILKL 206
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
47-430 |
2.85e-86 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 275.49 E-value: 2.85e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 47 SFEELGLDSRLIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLfsadsVSKKKLAPSAFIL 126
Cdd:COG0513 3 SFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRL-----DPSRPRAPQALIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 127 VPSRELCQQVYTEVSSLIELCRvqLKAVQLTSSMSASDMRNALAGLPEILVSTPACIPKCFAAGVLEPTAVseslSILVL 206
Cdd:COG0513 78 APTRELALQVAEELRKLAKYLG--LRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERGALDLSGV----ETLVL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 207 DEADLLLSYGYEDNLRSVTSIIPRRCQCLLMSATTSSDVEKLKKLILHNPIVLTLTEdndkEEAVPSNVQQFWISCSAQD 286
Cdd:COG0513 152 DEADRMLDMGFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAP----ENATAETIEQRYYLVDKRD 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 287 KLLHILALLKLEVVQkKILIFINTIDMGFRLKLFLEKFGIKSAILNGELPQNSRLHILEQFNAGLFDYLIATDdnsqtkk 366
Cdd:COG0513 228 KLELLRRLLRDEDPE-RAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATD------- 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15236218 367 qkeeakgeankenkknnkrskpkLDAefgvvRGIDFKKVHTVINFDMPQSVTGYIHRIGRTGRA 430
Cdd:COG0513 300 -----------------------VAA-----RGIDIDDVSHVINYDLPEDPEDYVHRIGRTGRA 335
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
57-260 |
4.71e-60 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 198.82 E-value: 4.71e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 57 LIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLFSADSVSKKKlaPSAFILVPSRELCQQV 136
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPKKKGRG--PQALVLAPTRELAMQI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 137 YTEVSSLIELCRvqLKAVQLTSSMSASDMRNALAGLPEILVSTPACIpkcfaAGVLEPTAVS-ESLSILVLDEADLLLSY 215
Cdd:cd00268 79 AEVARKLGKGTG--LKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRL-----LDLIERGKLDlSNVKYLVLDEADRMLDM 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 15236218 216 GYEDNLRSVTSIIPRRCQCLLMSATTSSDVEKLKKLILHNPIVLT 260
Cdd:cd00268 152 GFEEDVEKILSALPKDRQTLLFSATLPEEVKELAKKFLKNPVRIE 196
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
48-430 |
3.35e-54 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 190.92 E-value: 3.35e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 48 FEELGLDSRLIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLFsaDSVSKKKLAPSAFILV 127
Cdd:PRK11192 3 FSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLL--DFPRRKSGPPRILILT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 128 PSRELCQQVYTEVSSLIElcRVQLKAVQLTSSMSASDMRNALAGLPEILVSTPacipkcfaaGVL-----EPTAVSESLS 202
Cdd:PRK11192 81 PTRELAMQVADQARELAK--HTHLDIATITGGVAYMNHAEVFSENQDIVVATP---------GRLlqyikEENFDCRAVE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 203 ILVLDEADLLLSYGYEDNLRSVTSIIPRRCQCLLMSAT-TSSDVEKLKKLILHNPIVLtltedndkeEAVPS-----NVQ 276
Cdd:PRK11192 150 TLILDEADRMLDMGFAQDIETIAAETRWRKQTLLFSATlEGDAVQDFAERLLNDPVEV---------EAEPSrrerkKIH 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 277 QFW-ISCSAQDKLLHILALLKLEVVQKKIlIFINTIDMGFRLKLFLEKFGIKSAILNGELPQNSRLHILEQFNAGLFDYL 355
Cdd:PRK11192 221 QWYyRADDLEHKTALLCHLLKQPEVTRSI-VFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVL 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15236218 356 IATDDNSqtkkqkeeakgeankenkknnkrskpkldaefgvvRGIDFKKVHTVINFDMPQSVTGYIHRIGRTGRA 430
Cdd:PRK11192 300 VATDVAA-----------------------------------RGIDIDDVSHVINFDMPRSADTYLHRIGRTGRA 339
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
47-455 |
2.26e-47 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 172.69 E-value: 2.26e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 47 SFEELGLDSRLIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLFSADSVSKKKLAPSAFIL 126
Cdd:PRK10590 2 SFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPHAKGRRPVRALIL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 127 VPSRELCQQVYTEVSSLIELCRVQLKAVQLTSSMSASDMRnaLAGLPEILVSTPACIPKcfaagvLE-PTAVSES-LSIL 204
Cdd:PRK10590 82 TPTRELAAQIGENVRDYSKYLNIRSLVVFGGVSINPQMMK--LRGGVDVLVATPGRLLD------LEhQNAVKLDqVEIL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 205 VLDEADLLLSYGYEDNLRSVTSIIPRRCQCLLMSATTSSDVEKLKKLILHNPIVLTLTEDNDKEEAVPSNVQQFwiscsa 284
Cdd:PRK10590 154 VLDEADRMLDMGFIHDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTASEQVTQHVHFV------ 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 285 qDKLLHILALLKL--EVVQKKILIFINTIDMGFRLKLFLEKFGIKSAILNGELPQNSRLHILEQFNAGLFDYLIATDDns 362
Cdd:PRK10590 228 -DKKRKRELLSQMigKGNWQQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDI-- 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 363 qtkkqkeeakgeankenkknnkrskpkldaefgVVRGIDFKKVHTVINFDMPQSVTGYIHRIGRTGRAYSSGSSVSLISP 442
Cdd:PRK10590 305 ---------------------------------AARGLDIEELPHVVNYELPNVPEDYVHRIGRTGRAAATGEALSLVCV 351
|
410
....*....|...
gi 15236218 443 DEMEGFEDIKSFL 455
Cdd:PRK10590 352 DEHKLLRDIEKLL 364
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
44-430 |
7.64e-44 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 163.05 E-value: 7.64e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 44 APKSFEELGLDSRLIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLfsadsvSKKKLAPSA 123
Cdd:PRK11776 2 SMTAFSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKL------DVKRFRVQA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 124 FILVPSRELCQQVYTEVSSL---IElcrvQLKAVQLTSSMSasdMRNALAGL---PEILVSTPACIPKCFAAGVLeptaV 197
Cdd:PRK11776 76 LVLCPTRELADQVAKEIRRLarfIP----NIKVLTLCGGVP---MGPQIDSLehgAHIIVGTPGRILDHLRKGTL----D 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 198 SESLSILVLDEADLLLSYGYEDNLRSVTSIIPRRCQCLLMSATTSSDVEKLKKLILHNPIVLTLTEDNDKeeavpSNVQQ 277
Cdd:PRK11776 145 LDALNTLVLDEADRMLDMGFQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKVESTHDL-----PAIEQ 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 278 FWISCSAQDKllhilallkLEVVQKKI--------LIFINT-------IDMgfrlklfLEKFGIKSAILNGELPQNSRLH 342
Cdd:PRK11776 220 RFYEVSPDER---------LPALQRLLlhhqpescVVFCNTkkecqevADA-------LNAQGFSALALHGDLEQRDRDQ 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 343 ILEQFNAGLFDYLIATDdnsqtkkqkeeakgeankenkknnkrskpkldaefgvV--RGIDFKKVHTVINFDMPQSVTGY 420
Cdd:PRK11776 284 VLVRFANRSCSVLVATD-------------------------------------VaaRGLDIKALEAVINYELARDPEVH 326
|
410
....*....|
gi 15236218 421 IHRIGRTGRA 430
Cdd:PRK11776 327 VHRIGRTGRA 336
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
47-430 |
1.90e-43 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 165.02 E-value: 1.90e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 47 SFEELGLDSRLIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLfsaDSVSKkklAPSAFIL 126
Cdd:PRK11634 7 TFADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNL---DPELK---APQILVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 127 VPSRELCQQVYTEVSSLIELCRvQLKAVQLTSSMSASDMRNALAGLPEILVSTPACIPKCFAAGVLEPTavseSLSILVL 206
Cdd:PRK11634 81 APTRELAVQVAEAMTDFSKHMR-GVNVVALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRGTLDLS----KLSGLVL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 207 DEADLLLSYGYEDNLRSVTSIIPRRCQCLLMSATTSSDVEKLKKLILHNPivltltedndKEEAVPSNV-------QQFW 279
Cdd:PRK11634 156 DEADEMLRMGFIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEP----------QEVRIQSSVttrpdisQSYW 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 280 iSCSAQDKLLHILALLKLEVVQKKIlIFINTIDMGFRLKLFLEKFGIKSAILNGELPQNSRLHILEQFNAGLFDYLIATD 359
Cdd:PRK11634 226 -TVWGMRKNEALVRFLEAEDFDAAI-IFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATD 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15236218 360 dnsqtkkqkeeakgeankenkknnkrskpkldaefGVVRGIDFKKVHTVINFDMPQSVTGYIHRIGRTGRA 430
Cdd:PRK11634 304 -----------------------------------VAARGLDVERISLVVNYDIPMDSESYVHRIGRTGRA 339
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
47-257 |
2.44e-42 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 151.70 E-value: 2.44e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 47 SFEELGLDSRLIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLFSAdsvskkKLAPSAFIL 126
Cdd:cd17954 1 TFKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLEN------PQRFFALVL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 127 VPSRELCQQVYTEVSSLIELcrVQLKAVQLTSSMSASDMRNALAGLPEILVSTPACIpkcfaAGVLEPT-AVS-ESLSIL 204
Cdd:cd17954 75 APTRELAQQISEQFEALGSS--IGLKSAVLVGGMDMMAQAIALAKKPHVIVATPGRL-----VDHLENTkGFSlKSLKFL 147
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 15236218 205 VLDEADLLLSYGYEDNLRSVTSIIPRRCQCLLMSATTSSDVEKLKKLILHNPI 257
Cdd:cd17954 148 VMDEADRLLNMDFEPEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNPV 200
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
70-248 |
8.92e-42 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 148.54 E-value: 8.92e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 70 TLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLfsadsvSKKKLAPSAFILVPSRELCQQVYTEVSSLIELCRv 149
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEAL------DKLDNGPQALVLAPTRELAEQIYEELKKLGKGLG- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 150 qLKAVQLTSSMSASDMRNALAGlPEILVSTPAcipkcFAAGVLEPTAVSESLSILVLDEADLLLSYGYEDNLRSVTSIIP 229
Cdd:pfam00270 74 -LKVASLLGGDSRKEQLEKLKG-PDILVGTPG-----RLLDLLQERKLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLP 146
|
170
....*....|....*....
gi 15236218 230 RRCQCLLMSATTSSDVEKL 248
Cdd:pfam00270 147 KKRQILLLSATLPRNLEDL 165
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
48-430 |
1.27e-40 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 154.30 E-value: 1.27e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 48 FEELGLDSRLIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLFSADSVSKKKLA-PSAFIL 126
Cdd:PRK01297 89 FHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQTPPPKERYMGePRALII 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 127 VPSRELCQQVYTEVSSLIELcrVQLKAVQLTSSMSASDMRNAL-AGLPEILVSTPACIPKCFAAGVLEPTAVseslSILV 205
Cdd:PRK01297 169 APTRELVVQIAKDAAALTKY--TGLNVMTFVGGMDFDKQLKQLeARFCDILVATPGRLLDFNQRGEVHLDMV----EVMV 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 206 LDEADLLLSYGYEDNLRSVTSIIPRRC--QCLLMSATTSSDVEKLKKLILHNPIVLTLTEDNDKEEavpsNVQQFWISCS 283
Cdd:PRK01297 243 LDEADRMLDMGFIPQVRQIIRQTPRKEerQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPENVASD----TVEQHVYAVA 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 284 AQDKLLHILALLKLEVVQkKILIFINTIDMGFRLKLFLEKFGIKSAILNGELPQNSRLHILEQFNAGLFDYLIATDdnsq 363
Cdd:PRK01297 319 GSDKYKLLYNLVTQNPWE-RVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATD---- 393
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15236218 364 tkkqkeeAKGeankenkknnkrskpkldaefgvvRGIDFKKVHTVINFDMPQSVTGYIHRIGRTGRA 430
Cdd:PRK01297 394 -------VAG------------------------RGIHIDGISHVINFTLPEDPDDYVHRIGRTGRA 429
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
57-257 |
1.30e-40 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 146.63 E-value: 1.30e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 57 LIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLFSADsvsKKKLAPSAFILVPSRELCQQV 136
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLLYRP---KKKAATRVLVLVPTRELAMQC 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 137 YTEVSSLIELCRVQLKAVqlTSSMSASDMRNALAGLPEILVSTPA----CIPKCFAAGVleptavsESLSILVLDEADLL 212
Cdd:cd17947 78 FSVLQQLAQFTDITFALA--VGGLSLKAQEAALRARPDIVIATPGrlidHLRNSPSFDL-------DSIEILVLDEADRM 148
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 15236218 213 LSYGYEDNLRSVTSIIPRRCQCLLMSATTSSDVEKLKKLILHNPI 257
Cdd:cd17947 149 LEEGFADELKEILRLCPRTRQTMLFSATMTDEVKDLAKLSLNKPV 193
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
47-259 |
2.70e-40 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 145.91 E-value: 2.70e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 47 SFEELGLDSRLIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLfsadSVSKKKLAPSAFIL 126
Cdd:cd17959 2 GFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKL----KAHSPTVGARALIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 127 VPSRELCQQVYTEVSSLieLCRVQLKAVQLTSSMSASDMRNALAGLPEILVSTPacipkcfaaGVLEPTAVSESLS---- 202
Cdd:cd17959 78 SPTRELALQTLKVTKEL--GKFTDLRTALLVGGDSLEEQFEALASNPDIIIATP---------GRLLHLLVEMNLKlssv 146
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 15236218 203 -ILVLDEADLLLSYGYEDNLRSVTSIIPRRCQCLLMSATTSSDVEKLKKLILHNPIVL 259
Cdd:cd17959 147 eYVVFDEADRLFEMGFAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVLI 204
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
57-257 |
5.88e-39 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 142.33 E-value: 5.88e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 57 LIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLFSADSVSKKKlAPSAFILVPSRELCQQV 136
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILLKRKANLKKG-QVGALIISPTRELATQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 137 YTEVSSLIELCRVQLKAVQLTSSMSAS-DMRNALAGLPEILVSTPACIPKCFAAGVlEPTAVSeSLSILVLDEADLLLSY 215
Cdd:cd17960 80 YEVLQSFLEHHLPKLKCQLLIGGTNVEeDVKKFKRNGPNILVGTPGRLEELLSRKA-DKVKVK-SLEVLVLDEADRLLDL 157
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 15236218 216 GYEDNLRSVTSIIPRRCQCLLMSATTSSDVEKLKKLILHNPI 257
Cdd:cd17960 158 GFEADLNRILSKLPKQRRTGLFSATQTDAVEELIKAGLRNPV 199
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
57-260 |
7.27e-39 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 141.78 E-value: 7.27e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 57 LIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLFSADSVSKKKlAPSAFILVPSRELCQQV 136
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHIMDQRELEKGE-GPIAVIVAPTRELAQQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 137 YTEVSSLIELcrVQLKAVQLTSSMSASDMRNALAGLPEILVSTPACIPKCFAAGVLEPTAVseslSILVLDEADLLLSYG 216
Cdd:cd17952 80 YLEAKKFGKA--YNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKKATNLQRV----TYLVLDEADRMFDMG 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 15236218 217 YEDNLRSVTS-IIPRRcQCLLMSATTSSDVEKLKKLILHNPIVLT 260
Cdd:cd17952 154 FEYQVRSIVGhVRPDR-QTLLFSATFKKKIEQLARDILSDPIRVV 197
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
47-454 |
1.82e-38 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 146.51 E-value: 1.82e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 47 SFEELGLDSRLIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKlfsadsVSKKKLAPSAFIL 126
Cdd:PTZ00424 29 SFDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQL------IDYDLNACQALIL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 127 VPSRELCQQVYTEVSSLIELCRVQLKAVqLTSSMSASDMRNALAGLpEILVSTPACIPKCFAAGVLEptavSESLSILVL 206
Cdd:PTZ00424 103 APTRELAQQIQKVVLALGDYLKVRCHAC-VGGTVVRDDINKLKAGV-HMVVGTPGRVYDMIDKRHLR----VDDLKLFIL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 207 DEADLLLSYGYEDNLRSVTSIIPRRCQCLLMSATTSSDVEKLKKLILHNPIVLTLTedndKEEAVPSNVQQFWISCSAQD 286
Cdd:PTZ00424 177 DEADEMLSRGFKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVK----KDELTLEGIRQFYVAVEKEE 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 287 KLLHILALLKLEVVQKKILIFINT---IDMgFRLKLFLEKFGIKSaiLNGELPQNSRLHILEQFNAGLFDYLIATDdnsq 363
Cdd:PTZ00424 253 WKFDTLCDLYETLTITQAIIYCNTrrkVDY-LTKKMHERDFTVSC--MHGDMDQKDRDLIMREFRSGSTRVLITTD---- 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 364 tkkqkeeakgeankenkknnkrskpkldaefGVVRGIDFKKVHTVINFDMPQSVTGYIHRIGRTGRAYSSGSSVSLISPD 443
Cdd:PTZ00424 326 -------------------------------LLARGIDVQQVSLVINYDLPASPENYIHRIGRSGRFGRKGVAINFVTPD 374
|
410
....*....|.
gi 15236218 444 EMEGFEDIKSF 454
Cdd:PTZ00424 375 DIEQLKEIERH 385
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
48-257 |
9.72e-38 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 138.97 E-value: 9.72e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 48 FEELGLDSRLIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLFSadsvskKKLAPSAFILV 127
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKIDP------KKDVIQALILV 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 128 PSRELCQQVYTEVSSLIELCRVQLKAVQLTSSMSASDMRnaLAGLPEILVSTPACIPKCFAAGVleptAVSESLSILVLD 207
Cdd:cd17940 75 PTRELALQTSQVCKELGKHMGVKVMVTTGGTSLRDDIMR--LYQTVHVLVGTPGRILDLAKKGV----ADLSHCKTLVLD 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 15236218 208 EADLLLSYGYEDNLRSVTSIIPRRCQCLLMSATTSSDVEKLKKLILHNPI 257
Cdd:cd17940 149 EADKLLSQDFQPIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNPY 198
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
61-278 |
5.68e-37 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 136.85 E-value: 5.68e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 61 LTKKGIEKPTLIQQSAIPYILEG-KDVVARAKTGSGKTLAYLLPLLQKLfsadsvsKKKLAPSAFILVPSRELCQQVYTE 139
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEAL-------KRGKGGRVLVLVPTRELAEQWAEE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 140 VSSLIELCRVQlKAVQLTSSMSASDMRNALAGLPEILVSTPACIPKCFAAGVLEptavSESLSILVLDEADLLLSYGYED 219
Cdd:smart00487 74 LKKLGPSLGLK-VVGLYGGDSKREQLRKLESGKTDILVTTPGRLLDLLENDKLS----LSNVDLVILDEAHRLLDGGFGD 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 15236218 220 NLRSVTSIIPRRCQCLLMSATTSSDVEKLKKLILHNPIVLtltednDKEEAVPSNVQQF 278
Cdd:smart00487 149 QLEKLLKLLPKNVQLLLLSATPPEEIENLLELFLNDPVFI------DVGFTPLEPIEQF 201
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
57-260 |
9.15e-37 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 136.56 E-value: 9.15e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 57 LIRALTKK-GIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLFSADSVSKKKLAPSAFILVPSRELCQQ 135
Cdd:cd17949 1 LVSHLKSKmGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSLEPRVDRSDGTLALVLVPTRELALQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 136 VYTEVSSLIELCR--VqlkavqlTSSMSASDMRNA-----LAGLPeILVSTPACI------PKCFaagvleptaVSESLS 202
Cdd:cd17949 81 IYEVLEKLLKPFHwiV-------PGYLIGGEKRKSekarlRKGVN-ILIATPGRLldhlknTQSF---------DVSNLR 143
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15236218 203 ILVLDEADLLLSYGYEDNLRSVTSII-------------PRRCQCLLMSATTSSDVEKLKKLILHNPIVLT 260
Cdd:cd17949 144 WLVLDEADRLLDMGFEKDITKILELLddkrskaggekskPSRRQTVLVSATLTDGVKRLAGLSLKDPVYID 214
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
48-256 |
1.74e-36 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 135.43 E-value: 1.74e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 48 FEELGLDSRLIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLfsadsvSKKKLAPSAFILV 127
Cdd:cd17955 1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRL------SEDPYGIFALVLT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 128 PSRELCQQVYTEVSSLIELcrVQLKAVQLTSSMSASDMRNALAGLPEILVSTPACIPKCFAAGVLEPTAVSEsLSILVLD 207
Cdd:cd17955 75 PTRELAYQIAEQFRALGAP--LGLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLRSSDDTTKVLSR-VKFLVLD 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 15236218 208 EADLLLSYGYEDNLRSVTSIIPRRCQCLLMSATTSSDVEKLKKLILHNP 256
Cdd:cd17955 152 EADRLLTGSFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKP 200
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
45-430 |
3.11e-36 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 142.99 E-value: 3.11e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 45 PK---SFEELGLDSRLIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLfSADSVSKKKLAP 121
Cdd:PTZ00110 126 PKpvvSFEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAIVHI-NAQPLLRYGDGP 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 122 SAFILVPSRELCQQVYTEvsslielcrvqlkAVQLTSSmsaSDMRNALA--GLP------------EILVSTPACIPKCF 187
Cdd:PTZ00110 205 IVLVLAPTRELAEQIREQ-------------CNKFGAS---SKIRNTVAygGVPkrgqiyalrrgvEILIACPGRLIDFL 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 188 AAGVLEPTAVseslSILVLDEADLLLSYGYEDNLRSVTSII-PRRcQCLLMSATTSSDVEKL-KKLILHNPI-----VLT 260
Cdd:PTZ00110 269 ESNVTNLRRV----TYLVLDEADRMLDMGFEPQIRKIVSQIrPDR-QTLMWSATWPKEVQSLaRDLCKEEPVhvnvgSLD 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 261 LTEDNdkeeavpsNVQQFWISCSAQDKLLHILALLKLEVVQ-KKILIFINTIDMGFRLKLFLEKFGIKSAILNGELPQNS 339
Cdd:PTZ00110 344 LTACH--------NIKQEVFVVEEHEKRGKLKMLLQRIMRDgDKILIFVETKKGADFLTKELRLDGWPALCIHGDKKQEE 415
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 340 RLHILEQFNAGLFDYLIATDDNSqtkkqkeeakgeankenkknnkrskpkldaefgvvRGIDFKKVHTVINFDMPQSVTG 419
Cdd:PTZ00110 416 RTWVLNEFKTGKSPIMIATDVAS-----------------------------------RGLDVKDVKYVINFDFPNQIED 460
|
410
....*....|.
gi 15236218 420 YIHRIGRTGRA 430
Cdd:PTZ00110 461 YVHRIGRTGRA 471
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
46-430 |
4.91e-36 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 140.11 E-value: 4.91e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 46 KSFEELGLDSRLIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLFS-ADSVSKKKLAPSAF 124
Cdd:PRK04837 8 QKFSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYLLShPAPEDRKVNQPRAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 125 ILVPSRELCQQVYTEVSSLIELCrvQLKAVQLTSSMSASDMRNALAGLPEILVSTPACIPKCFAAGVLEPTAVseslSIL 204
Cdd:PRK04837 88 IMAPTRELAVQIHADAEPLAQAT--GLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINLGAI----QVV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 205 VLDEADLLLSYGYEDNLRSVTSIIPRRCQCLLM--SATTSSDVEKLKKLILHNPIVLTL-----TEDNDKEEAV-PSNvq 276
Cdd:PRK04837 162 VLDEADRMFDLGFIKDIRWLFRRMPPANQRLNMlfSATLSYRVRELAFEHMNNPEYVEVepeqkTGHRIKEELFyPSN-- 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 277 qfwiscsaQDKLLHILALLKLEVVQKKIlIFINTIDMGFRLKLFLEKFGIKSAILNGELPQNSRLHILEQFNAGLFDYLI 356
Cdd:PRK04837 240 --------EEKMRLLQTLIEEEWPDRAI-IFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILEEFTRGDLDILV 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15236218 357 ATDdnsqtkkqkeeakgeankenkknnkrskpkldaefgV-VRGIDFKKVHTVINFDMPQSVTGYIHRIGRTGRA 430
Cdd:PRK04837 311 ATD------------------------------------VaARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRA 349
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
46-260 |
6.00e-36 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 134.43 E-value: 6.00e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 46 KSFEELGLDSRLIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLFSADSVsKKKLAPSAFI 125
Cdd:cd17953 12 QKWSQCGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHIKDQRPV-KPGEGPIGLI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 126 LVPSRELCQQVYTEVSSLIELcrVQLKAVQLTSSMSASDMRNALAGLPEILVSTPACIPKCFAAGVLEPTAVsESLSILV 205
Cdd:cd17953 91 MAPTRELALQIYVECKKFSKA--LGLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDILTANNGRVTNL-RRVTYVV 167
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 15236218 206 LDEADLLLSYGYEDNL-RSVTSIIPRRcQCLLMSATTSSDVEKLKKLILHNPIVLT 260
Cdd:cd17953 168 LDEADRMFDMGFEPQImKIVNNIRPDR-QTVLFSATFPRKVEALARKVLHKPIEIT 222
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
275-430 |
6.75e-36 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 131.09 E-value: 6.75e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 275 VQQFWISCSAQDKLLHILALLKLEVVQKKILIFINTIDMGFRLKLFLEKFGIKSAILNGELPQNSRLHILEQFNAGLFDY 354
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15236218 355 LIATDdnsqtkkqkeeakgeankenkknnkrskpkldaefgVV-RGIDFKKVHTVINFDMPQSVTGYIHRIGRTGRA 430
Cdd:cd18787 81 LVATD------------------------------------VAaRGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRA 121
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
57-260 |
1.34e-35 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 132.71 E-value: 1.34e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 57 LIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLfsadSVSKKKLAPSAFILVPSRELCQQV 136
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKL----GKPRKKKGLRALILAPTRELASQI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 137 YTEVSSLIELCRVQLKAVQLTSSMSASDMRNALAGlPEILVSTPACIpkCFAagvLEPTAVS-ESLSILVLDEADLLLsy 215
Cdd:cd17957 77 YRELLKLSKGTGLRIVLLSKSLEAKAKDGPKSITK-YDILVSTPLRL--VFL---LKQGPIDlSSVEYLVLDEADKLF-- 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 15236218 216 gyEDNLRSVTSIIPRRC-----QCLLMSATTSSDVEKLKKLILHNPIVLT 260
Cdd:cd17957 149 --EPGFREQTDEILAACtnpnlQRSLFSATIPSEVEELARSVMKDPIRII 196
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
53-253 |
1.48e-35 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 133.09 E-value: 1.48e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 53 LDSRLIRALTKKGIEKPTLIQQSAIPYILE-GKDVVARAKTGSGKTLAYLLPLLQKLFSadsvSKKKLAPS---AFILVP 128
Cdd:cd17964 1 LDPSLLKALTRMGFETMTPVQQKTLKPILStGDDVLARAKTGTGKTLAFLLPAIQSLLN----TKPAGRRSgvsALIISP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 129 SRELCQQVYTEVSSLIELCR---VQLkAVQLTSSMsaSDMRNALAGLPEILVSTP----ACIPKCFAAGVLeptavsESL 201
Cdd:cd17964 77 TRELALQIAAEAKKLLQGLRklrVQS-AVGGTSRR--AELNRLRRGRPDILVATPgrliDHLENPGVAKAF------TDL 147
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 15236218 202 SILVLDEADLLLSYGYEDNLRSVTSIIPRRC----QCLLMSATTSSDVEKLKKLIL 253
Cdd:cd17964 148 DYLVLDEADRLLDMGFRPDLEQILRHLPEKNadprQTLLFSATVPDEVQQIARLTL 203
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
57-248 |
8.93e-35 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 131.72 E-value: 8.93e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 57 LIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLFSADSVSKKKL-APSAFILVPSRELCQQ 135
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRYKLLAEGPFnAPRGLVITPSRELAEQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 136 VYTEVSSLIElcRVQLKAVQLTSSMSASDMRNALAGLPEILVSTPACIPKCFAAGVLEptavSESLSILVLDEADLLLSY 215
Cdd:cd17948 81 IGSVAQSLTE--GLGLKVKVITGGRTKRQIRNPHFEEVDILVATPGALSKLLTSRIYS----LEQLRHLVLDEADTLLDD 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 15236218 216 GYEDNLR-------------SVTSIIPRRCQCLLMSATTSSDVEKL 248
Cdd:cd17948 155 SFNEKLShflrrfplasrrsENTDGLDPGTQLVLVSATMPSGVGEV 200
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
59-257 |
1.30e-33 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 127.02 E-value: 1.30e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 59 RALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLFSADSVSKKKLApsAFILVPSRELCQQVYt 138
Cdd:cd17941 3 KGLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLYRERWTPEDGLG--ALIISPTRELAMQIF- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 139 EVsslieLCRV----QLKAVQLTSSMSASDMRNALAGLpEILVSTPacipkcfaaGVL------EPTAVSESLSILVLDE 208
Cdd:cd17941 80 EV-----LRKVgkyhSFSAGLIIGGKDVKEEKERINRM-NILVCTP---------GRLlqhmdeTPGFDTSNLQMLVLDE 144
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 15236218 209 ADLLLSYGYEDNLRSVTSIIPRRCQCLLMSATTSSDVEKLKKLILHNPI 257
Cdd:cd17941 145 ADRILDMGFKETLDAIVENLPKSRQTLLFSATQTKSVKDLARLSLKNPE 193
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
47-260 |
3.88e-32 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 123.75 E-value: 3.88e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 47 SFEELGLDSRLIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLF----SADSVSKKKLAPS 122
Cdd:cd17967 1 SFEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLedgpPSVGRGRRKAYPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 123 AFILVPSRELCQQVYTEVSSLIElcRVQLKAVQL---TSSMsaSDMRNALAGLpEILVSTPacipkcfaaG----VLEPT 195
Cdd:cd17967 81 ALILAPTRELAIQIYEEARKFSY--RSGVRSVVVyggADVV--HQQLQLLRGC-DILVATP---------GrlvdFIERG 146
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15236218 196 AVS-ESLSILVLDEADLLLSYGYEDNLRSV------TSIIPRrcQCLLMSATTSSDVEKLKKLILHNPIVLT 260
Cdd:cd17967 147 RISlSSIKFLVLDEADRMLDMGFEPQIRKIvehpdmPPKGER--QTLMFSATFPREIQRLAADFLKNYIFLT 216
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
57-260 |
4.49e-32 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 123.58 E-value: 4.49e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 57 LIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLFSADSVS--KKKLAPSAFILVPSRELCQ 134
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLPPLDeeTKDDGPYALILAPTRELAQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 135 QVYTEVSSLIELCRvqLKAVQLTSSMSASDMRNALAGLPEILVSTPACIPKCfaagvLEPT-AVSESLSILVLDEADLLL 213
Cdd:cd17945 81 QIEEETQKFAKPLG--IRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDC-----LERRlLVLNQCTYVVLDEADRMI 153
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15236218 214 SYGYEDNLRSVTSIIP--------------------RRCQCLLMSATTSSDVEKLKKLILHNPIVLT 260
Cdd:cd17945 154 DMGFEPQVTKILDAMPvsnkkpdteeaeklaasgkhRYRQTMMFTATMPPAVEKIAKGYLRRPVVVT 220
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
47-507 |
9.43e-32 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 130.07 E-value: 9.43e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 47 SFEELGLDSRLIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLFSADSVSKKKLA-PSAFI 125
Cdd:PRK04537 10 TFSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSRPALADRKPEdPRALI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 126 LVPSRELCQQVYTEVSSLieLCRVQLKAVQLTSSMSASDMRNALAGLPEILVSTPACIPKCfaagVLEPTAVS-ESLSIL 204
Cdd:PRK04537 90 LAPTRELAIQIHKDAVKF--GADLGLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDY----VKQHKVVSlHACEIC 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 205 VLDEADLLLSYGYEDNLRSVTSIIPRRC--QCLLMSATTSSDVEKLKKLILHNPIVLTLtednDKEEAVPSNVQQfWISC 282
Cdd:PRK04537 164 VLDEADRMFDLGFIKDIRFLLRRMPERGtrQTLLFSATLSHRVLELAYEHMNEPEKLVV----ETETITAARVRQ-RIYF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 283 SAQDKLLHILALLKLEVVQKKILIFINTIDMGFRLKLFLEKFGIKSAILNGELPQNSRLHILEQFNAGLFDYLIATDdns 362
Cdd:PRK04537 239 PADEEKQTLLLGLLSRSEGARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATD--- 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 363 qtkkqkeeakgeankenkknnkrskpkldaefGVVRGIDFKKVHTVINFDMPQSVTGYIHRIGRTGRAYSSGSSVSLISP 442
Cdd:PRK04537 316 --------------------------------VAARGLHIDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISFACE 363
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15236218 443 DEMEGFEDIKSFLASD---KNKDIDIITPFPLLTENAVESLRYRAEDvAKSVTKIAvRESRAQDLRNE 507
Cdd:PRK04537 364 RYAMSLPDIEAYIEQKipvEPVTAELLTPLPRPPRVPVEGEEADDEA-GDSVGTIF-REAREQRAAEE 429
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
48-256 |
2.11e-31 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 121.27 E-value: 2.11e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 48 FEELGLDSRLIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLfsadsvskkklapSAFILV 127
Cdd:cd17938 1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQIV-------------VALILE 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 128 PSRELCQQVYTEVSSLI-ELCRVQLKAVQLTSSMSASDMRNALAGLPEILVSTPACIPKCFAAGVLEPTAVseslSILVL 206
Cdd:cd17938 68 PSRELAEQTYNCIENFKkYLDNPKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGKLDLSSV----RFFVL 143
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 15236218 207 DEADLLLSYGYEDNLRSVTSIIP------RRCQCLLMSATT-SSDVEKLKKLILHNP 256
Cdd:cd17938 144 DEADRLLSQGNLETINRIYNRIPkitsdgKRLQVIVCSATLhSFEVKKLADKIMHFP 200
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
50-257 |
4.68e-31 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 120.12 E-value: 4.68e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 50 ELGLDSRLIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLfsaDSVSKKklaPSAFILVPS 129
Cdd:cd17939 1 DMGLSEDLLRGIYAYGFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRI---DTTVRE---TQALVLAPT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 130 RELCQQVYTEVSSLieLCRVQLKAVQLTSSMSASDMRNALAGLPEILVSTPacipkCFAAGVLEPTAVS-ESLSILVLDE 208
Cdd:cd17939 75 RELAQQIQKVVKAL--GDYMGVKVHACIGGTSVREDRRKLQYGPHIVVGTP-----GRVFDMLQRRSLRtDKIKMFVLDE 147
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 15236218 209 ADLLLSYGYEDNLRSVTSIIPRRCQCLLMSATTSSDVEKLKKLILHNPI 257
Cdd:cd17939 148 ADEMLSRGFKDQIYDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDPV 196
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
48-257 |
6.59e-31 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 119.86 E-value: 6.59e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 48 FEELGLDSRLIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLfsadSVSKKklAPSAFILV 127
Cdd:cd18046 1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQI----DTSLK--ATQALVLA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 128 PSRELCQQVYTEVSSLIELCRVQLKAVqlTSSMSASDMRNALAGLPEILVSTPACIPKCFAAGVLEPtavsESLSILVLD 207
Cdd:cd18046 75 PTRELAQQIQKVVMALGDYMGIKCHAC--IGGTSVRDDAQKLQAGPHIVVGTPGRVFDMINRRYLRT----DYIKMFVLD 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 15236218 208 EADLLLSYGYEDNLRSVTSIIPRRCQCLLMSATTSSDVEKLKKLILHNPI 257
Cdd:cd18046 149 EADEMLSRGFKDQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDPI 198
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
47-429 |
1.03e-30 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 126.44 E-value: 1.03e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 47 SFEELGLDSRLIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQK--LFSADSVSKKKlAPSAF 124
Cdd:PLN00206 122 SFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRccTIRSGHPSEQR-NPLAM 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 125 ILVPSRELCQQVYTEVSSLIELCRVQLKAVQLTSSMSASDMRnaLAGLPEILVSTPACIPKCFAAGVLEPTAVseslSIL 204
Cdd:PLN00206 201 VLTPTRELCVQVEDQAKVLGKGLPFKTALVVGGDAMPQQLYR--IQQGVELIVGTPGRLIDLLSKHDIELDNV----SVL 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 205 VLDEADLLLSYGYEDNLRSVTSIIPRRcQCLLMSATTSSDVEKLKKLILHNPIVLTLTEDNDKEEAVPSNVqqFWIScSA 284
Cdd:PLN00206 275 VLDEVDCMLERGFRDQVMQIFQALSQP-QVLLFSATVSPEVEKFASSLAKDIILISIGNPNRPNKAVKQLA--IWVE-TK 350
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 285 QDKLLHILALLKLEVVQKKILIFINTiDMGFRL--KLFLEKFGIKSAILNGELPQNSRLHILEQFNAGLFDYLIATddns 362
Cdd:PLN00206 351 QKKQKLFDILKSKQHFKPPAVVFVSS-RLGADLlaNAITVVTGLKALSIHGEKSMKERREVMKSFLVGEVPVIVAT---- 425
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15236218 363 qtkkqkeeakgeankenkknnkrskpkldaefGVV-RGIDFKKVHTVINFDMPQSVTGYIHRIGRTGR 429
Cdd:PLN00206 426 --------------------------------GVLgRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASR 461
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
59-256 |
7.11e-30 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 116.69 E-value: 7.11e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 59 RALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLFsadsvsKKKLAP----SAFILVPSRELCQ 134
Cdd:cd17942 3 KAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELLY------KLKFKPrngtGVIIISPTRELAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 135 QVYTEVSSLIELCRVQLKAVQLTSSMSASDMRnaLAGLPEILVSTPacipkcfaaGVL------EPTAVSESLSILVLDE 208
Cdd:cd17942 77 QIYGVAKELLKYHSQTFGIVIGGANRKAEAEK--LGKGVNILVATP---------GRLldhlqnTKGFLYKNLQCLIIDE 145
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 15236218 209 ADLLLSYGYEDNLRSVTSIIPRRCQCLLMSATTSSDVEKLKKLILHNP 256
Cdd:cd17942 146 ADRILEIGFEEEMRQIIKLLPKRRQTMLFSATQTRKVEDLARISLKKK 193
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
57-256 |
3.57e-29 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 115.81 E-value: 3.57e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 57 LIRALTKKGIEKPTLIQQSAIPYILEG---------KDVVARAKTGSGKTLAYLLPLLQKLFSAdsvSKKKLapSAFILV 127
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAAVIPWLLPSskstppyrpGDLCVSAPTGSGKTLAYVLPIVQALSKR---VVPRL--RALIVV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 128 PSRELCQQVYTEVSSLIElcRVQLKAVQLTSSMSASDMRNALAG--------LPEILVSTPACipkcFAAGVLEPTAVS- 198
Cdd:cd17956 76 PTKELVQQVYKVFESLCK--GTGLKVVSLSGQKSFKKEQKLLLVdtsgrylsRVDILVATPGR----LVDHLNSTPGFTl 149
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15236218 199 ESLSILVLDEADLLLSYGYEDNL--------------------RSVTSIIPRRCQCLLMSATTSSDVEKLKKLILHNP 256
Cdd:cd17956 150 KHLRFLVIDEADRLLNQSFQDWLetvmkalgrptapdlgsfgdANLLERSVRPLQKLLFSATLTRDPEKLSSLKLHRP 227
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
57-260 |
7.20e-29 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 113.71 E-value: 7.20e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 57 LIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLFSADSVSKKKLAPSAFILVPSRELCQQV 136
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDLQPIPREQRNGPGVLVLTPTRELALQI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 137 YTEVSsliELCRVQLKAVQLTSSMSASDMRNALAGLPEILVSTPACIPKCFAAGVLEptavSESLSILVLDEADLLLSYG 216
Cdd:cd17958 81 EAECS---KYSYKGLKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMNNVIN----LKSITYLVLDEADRMLDMG 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 15236218 217 YEDNLR-SVTSIIPRRcQCLLMSATTSSDVEKLKKLILHNPIVLT 260
Cdd:cd17958 154 FEPQIRkILLDIRPDR-QTIMTSATWPDGVRRLAQSYLKDPMIVY 197
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
57-260 |
1.97e-28 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 112.26 E-value: 1.97e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 57 LIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLFSadsvskKKLAPSAFILVPSRELCQQV 136
Cdd:cd17962 1 LSSNLKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCLT------EHRNPSALILTPTRELAVQI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 137 YTEVSSLIElCRVQLKAVQLTSSMSASDMRNALAGLPEILVSTPACIPKCFAAGVLEptavSESLSILVLDEADLLLSYG 216
Cdd:cd17962 75 EDQAKELMK-GLPPMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQSSVE----LDNIKIVVVDEADTMLKMG 149
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 15236218 217 YEDNLRSVTSIIPRRCQCLLMSATTSSDVEKLKKLILHNPIVLT 260
Cdd:cd17962 150 FQQQVLDILENISHDHQTILVSATIPRGIEQLAGQLLQNPVRIT 193
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
53-260 |
5.14e-28 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 111.13 E-value: 5.14e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 53 LDSRLIRALTKKGIEKPTLIQQSAIPYILEG--KDVVARAKTGSGKTLAYLLPLLQKlfsadsVSKKKLAPSAFILVPSR 130
Cdd:cd17963 1 LKPELLKGLYAMGFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLAMLSR------VDPTLKSPQALCLAPTR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 131 ELCQQVYTEVSSLielcrVQLKAVQLTSSMSASDMRNALAGLPEILVSTP-----ACIPKCFAAgvleptavsESLSILV 205
Cdd:cd17963 75 ELARQIGEVVEKM-----GKFTGVKVALAVPGNDVPRGKKITAQIVIGTPgtvldWLKKRQLDL---------KKIKILV 140
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 15236218 206 LDEADLLL-SYGYEDNLRSVTSIIPRRCQCLLMSATTSSDVEKLKKLILHNPIVLT 260
Cdd:cd17963 141 LDEADVMLdTQGHGDQSIRIKRMLPRNCQILLFSATFPDSVRKFAEKIAPNANTIK 196
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
57-257 |
6.63e-27 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 108.23 E-value: 6.63e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 57 LIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLfSADSVSKKKLAPSAFILVPSRELCQQV 136
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHI-NAQPPLERGDGPIVLVLAPTRELAQQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 137 YTEVSSLIELCRVQLKAVQ--LTSSMSASDMRNAlaglPEILVSTPACIPKCFAAGvlepTAVSESLSILVLDEADLLLS 214
Cdd:cd17966 80 QQEANKFGGSSRLRNTCVYggAPKGPQIRDLRRG----VEICIATPGRLIDFLDQG----KTNLRRVTYLVLDEADRMLD 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 15236218 215 YGYEDNLRSVTSII-PRRcQCLLMSATTSSDVEKLKKLILHNPI 257
Cdd:cd17966 152 MGFEPQIRKIVDQIrPDR-QTLMWSATWPKEVRRLAEDFLKDYI 194
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
44-248 |
9.66e-27 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 109.67 E-value: 9.66e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 44 APKSFEELGLDSRLIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLFS---ADSVSKKKLA 120
Cdd:cd18052 41 AILTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMMKeglTASSFSEVQE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 121 PSAFILVPSRELCQQVYTEVSSLIElcRVQLKAVQLTSSMSAS-DMRNALAGLpEILVSTPACIPKCFAAGVleptaVS- 198
Cdd:cd18052 121 PQALIVAPTRELANQIFLEARKFSY--GTCIRPVVVYGGVSVGhQIRQIEKGC-HILVATPGRLLDFIGRGK-----ISl 192
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 15236218 199 ESLSILVLDEADLLLSYGYEDNLRSVTSI--IPRRC--QCLLMSATTSSDVEKL 248
Cdd:cd18052 193 SKLKYLILDEADRMLDMGFGPEIRKLVSEpgMPSKEdrQTLMFSATFPEEIQRL 246
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
57-259 |
2.12e-26 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 107.04 E-value: 2.12e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 57 LIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLqkLFSADsvSKKKLA------PSAFILVPSR 130
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLI--MFALE--QEKKLPfikgegPYGLIVCPSR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 131 ELCQQVYTEVSSLIELCRV----QLKAVQLTSSMSASDMRNALAGLPEILVSTPACIPKCFAAGVLeptavseSLSI--- 203
Cdd:cd17951 77 ELARQTHEVIEYYCKALQEggypQLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLNKKKI-------NLDIcry 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 15236218 204 LVLDEADLLLSYGYEDNLRSVTSIIPRRCQCLLMSATTSSDVEKLKKLILHNPIVL 259
Cdd:cd17951 150 LCLDEADRMIDMGFEEDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTV 205
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
57-244 |
4.83e-26 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 106.94 E-value: 4.83e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 57 LIRALTKKGIEKPTLIQQSAIPY-ILEGKDVVARAKTGSGKTLAYLLPLLQKLFSADS---VSKKKLAPSAFILVPSREL 132
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPAaIRDGKDVIGAAETGSGKTLAFGIPILERLLSQKSsngVGGKQKPLRALILTPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 133 CQQVyteVSSLIELCR-VQLKAVQLTSSMSASDMRNALAGLPEILVSTPACIPKCFAAGVlEPTAVSESLSILVLDEADL 211
Cdd:cd17946 81 AVQV---KDHLKAIAKyTNIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIQEGN-EHLANLKSLRFLVLDEADR 156
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 15236218 212 LLSYGYEDNLRSVTSIIP-------RRCQCLLMSATTSSD 244
Cdd:cd17946 157 MLEKGHFAELEKILELLNkdragkkRKRQTFVFSATLTLD 196
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
46-264 |
1.14e-22 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 97.01 E-value: 1.14e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 46 KSFEELGLDSRLIRALTKKGIEKPTLIQQSAIPYILEG--KDVVARAKTGSGKTLAYLLPLLQKlfsadsVSKKKLAPSA 123
Cdd:cd18048 18 KSFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSR------VDALKLYPQC 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 124 FILVPSRELCQQVYTEVSSLIELCrvqlKAVQLTSSMSASDMRNALAGLPEILVSTPACIPK-CFAAGVLEptavSESLS 202
Cdd:cd18048 92 LCLSPTFELALQTGKVVEEMGKFC----VGIQVIYAIRGNRPGKGTDIEAQIVIGTPGTVLDwCFKLRLID----VTNIS 163
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15236218 203 ILVLDEADLLLSY-GYEDNLRSVTSIIPRRCQCLLMSATTSSDVEKLKKLILHNPIVLTLTED 264
Cdd:cd18048 164 VFVLDEADVMINVqGHSDHSVRVKRSMPKECQMLLFSATFEDSVWAFAERIVPDPNIIKLKKE 226
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
302-430 |
1.68e-22 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 92.66 E-value: 1.68e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 302 KKILIFINTIDMgFRLKLFLEKFGIKSAILNGELPQNSRLHILEQFNAGLFDYLIATDdnsqtkkqkeeakgeankenkk 381
Cdd:pfam00271 16 GKVLIFSQTKKT-LEAELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATD---------------------- 72
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 15236218 382 nnkrskpkldaefgVV-RGIDFKKVHTVINFDMPQSVTGYIHRIGRTGRA 430
Cdd:pfam00271 73 --------------VAeRGLDLPDVDLVINYDLPWNPASYIQRIGRAGRA 108
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
48-259 |
1.76e-22 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 95.61 E-value: 1.76e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 48 FEELGLDSRLIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLfsadSVSKKKlaPSAFILV 127
Cdd:cd18045 1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCL----DIQVRE--TQALILS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 128 PSRELCQQVYTEVSSLIELCRVQLKAVQLTSSMSaSDMRNALAGLpEILVSTPACIPKCFAAGVLEptavSESLSILVLD 207
Cdd:cd18045 75 PTRELAVQIQKVLLALGDYMNVQCHACIGGTSVG-DDIRKLDYGQ-HIVSGTPGRVFDMIRRRSLR----TRHIKMLVLD 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 15236218 208 EADLLLSYGYEDNLRSVTSIIPRRCQCLLMSATTSSDVEKLKKLILHNPIVL 259
Cdd:cd18045 149 EADEMLNKGFKEQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDPIRI 200
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
48-257 |
6.67e-22 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 95.08 E-value: 6.67e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 48 FEELGLDSRLIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLfSADSVSKKKLAPSAFILV 127
Cdd:cd18049 26 FYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHI-NHQPFLERGDGPICLVLA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 128 PSRELCQQVYTEVSSLIELCRVQLKAVqLTSSMSASDMRNALAGLpEILVSTPACIPKCFAAGvlePTAVSESlSILVLD 207
Cdd:cd18049 105 PTRELAQQVQQVAAEYGRACRLKSTCI-YGGAPKGPQIRDLERGV-EICIATPGRLIDFLEAG---KTNLRRC-TYLVLD 178
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 15236218 208 EADLLLSYGYEDNLRS-VTSIIPRRcQCLLMSATTSSDVEKLKKLILHNPI 257
Cdd:cd18049 179 EADRMLDMGFEPQIRKiVDQIRPDR-QTLMWSATWPKEVRQLAEDFLKDYI 228
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
47-260 |
7.55e-22 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 95.11 E-value: 7.55e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 47 SFEELGLdSRLIR---ALTKkgIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLFSADSV--------- 114
Cdd:cd18051 22 TFSDLDL-GEIIRnniELAR--YTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIYEQGPGeslpsesgy 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 115 -SKKKLAPSAFILVPSRELCQQVYTEVSSLIELCRVQLKAVQLTSSMSASdMRNALAGLpEILVSTPACIpkcfaAGVLE 193
Cdd:cd18051 99 yGRRKQYPLALVLAPTRELASQIYDEARKFAYRSRVRPCVVYGGADIGQQ-MRDLERGC-HLLVATPGRL-----VDMLE 171
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15236218 194 PTAVS-ESLSILVLDEADLLLSYGYEDNLRSVTS--IIPRRC--QCLLMSATTSSDVEKLKKLILHNPIVLT 260
Cdd:cd18051 172 RGKIGlDYCKYLVLDEADRMLDMGFEPQIRRIVEqdTMPPTGerQTLMFSATFPKEIQMLARDFLDNYIFLA 243
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
57-258 |
3.95e-21 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 91.56 E-value: 3.95e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 57 LIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQklfsadSVSKKKLAPSAFILVPSRELCQQV 136
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALE------SLDLERRHPQVLILAPTREIAVQI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 137 YTEVSSLIELCRVqLKAVQLTSSMSASDMRNALAGlPEILVSTPACIPKCFAAGVLEPtavsESLSILVLDEADLLLSYG 216
Cdd:cd17943 75 HDVFKKIGKKLEG-LKCEVFIGGTPVKEDKKKLKG-CHIAVGTPGRIKQLIELGALNV----SHVRLFVLDEADKLMEGS 148
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 15236218 217 YEDNLRSVTSIIPRRCQCLLMSATTSSDVEKLKKLILHNPIV 258
Cdd:cd17943 149 FQKDVNWIFSSLPKNKQVIAFSATYPKNLDNLLARYMRKPVL 190
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
68-247 |
5.22e-19 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 87.05 E-value: 5.22e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 68 KPTLIQQSAIPYILE---GKDVVAR-------------AKTGSGKTLAYLLPLLQKL---------FSADSVS--KKKLA 120
Cdd:cd17965 30 KPSPIQTLAIKKLLKtlmRKVTKQTsneepklevfllaAETGSGKTLAYLAPLLDYLkrqeqepfeEAEEEYEsaKDTGR 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 121 PSAFILVPSRELCQQVYTEVSSLIELcrVQLKAVQLTSSMSASDMRNALA--GLPEILVSTPACIPKCFAagvLEPTAVS 198
Cdd:cd17965 110 PRSVILVPTHELVEQVYSVLKKLSHT--VKLGIKTFSSGFGPSYQRLQLAfkGRIDILVTTPGKLASLAK---SRPKILS 184
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 15236218 199 eSLSILVLDEADLLLSYGYednLRSVTSIIPR--RCQCL-LMSATTSSDVEK 247
Cdd:cd17965 185 -RVTHLVVDEADTLFDRSF---LQDTTSIIKRapKLKHLiLCSATIPKEFDK 232
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
316-430 |
1.16e-18 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 80.72 E-value: 1.16e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 316 RLKLFLEKFGIKSAILNGELPQNSRLHILEQFNAGLFDYLIATDdnsqtkkqkeeakgeankenkknnkrskpkldaefg 395
Cdd:smart00490 2 ELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATD------------------------------------ 45
|
90 100 110
....*....|....*....|....*....|....*.
gi 15236218 396 VV-RGIDFKKVHTVINFDMPQSVTGYIHRIGRTGRA 430
Cdd:smart00490 46 VAeRGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRA 81
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
47-255 |
1.62e-18 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 85.83 E-value: 1.62e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 47 SFEELGLDSRLIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLFSADSVSKKKlAPSAFIL 126
Cdd:cd18050 63 AFHQANFPQYVMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERGD-GPICLVL 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 127 VPSRELCQQVYTEVSSLIELCRVQLKAVqLTSSMSASDMRNALAGLpEILVSTPACIPKCFAAGvlepTAVSESLSILVL 206
Cdd:cd18050 142 APTRELAQQVQQVADDYGKSSRLKSTCI-YGGAPKGPQIRDLERGV-EICIATPGRLIDFLEAG----KTNLRRCTYLVL 215
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 15236218 207 DEADLLLSYGYEDNLRSVTSIIPRRCQCLLMSATTSSDVEKLKKLILHN 255
Cdd:cd18050 216 DEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRD 264
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
46-259 |
3.25e-18 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 83.62 E-value: 3.25e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 46 KSFEELGLDSRLIRALTKKGIEKPTLIQQSAIPYILE--GKDVVARAKTGSGKTLAYLLPLLQKLFSADSVSKkklapsA 123
Cdd:cd18047 1 KSFEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAepPQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQ------C 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 124 FILVPSRELCQQvyteVSSLIELCRVQLKAVQLTSSMSASDMRNALAGLPEILVSTPACIPK-CFAAGVLEPtavsESLS 202
Cdd:cd18047 75 LCLSPTYELALQ----TGKVIEQMGKFYPELKLAYAVRGNKLERGQKISEQIVIGTPGTVLDwCSKLKFIDP----KKIK 146
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 15236218 203 ILVLDEADLLL-SYGYEDNLRSVTSIIPRRCQCLLMSATTSSDVEKLKKLILHNPIVL 259
Cdd:cd18047 147 VFVLDEADVMIaTQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVI 204
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
58-250 |
1.51e-17 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 81.43 E-value: 1.51e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 58 IRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLFSADSVSKKKLAPSAFILVPSRELCQQVY 137
Cdd:cd17944 2 IKLLQARGVTYLFPIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLQEDQQPRKRGRAPKVLVLAPTRELANQVT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 138 TEVSSLIElcrvQLKAVQLTSSMSASDMRNALAGLPEILVSTPACIPKCFAAGVLEPTAVSEslsiLVLDEADLLLSYGY 217
Cdd:cd17944 82 KDFKDITR----KLSVACFYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLDLTKLKH----VVLDEVDQMLDMGF 153
|
170 180 190
....*....|....*....|....*....|....*...
gi 15236218 218 EDNLRSVTSIIPRR-----CQCLLMSATTSSDVEKLKK 250
Cdd:cd17944 154 AEQVEEILSVSYKKdsednPQTLLFSATCPDWVYNVAK 191
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
47-256 |
3.44e-15 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 74.69 E-value: 3.44e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 47 SFEELGLDSRLIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLfsaDSVSKKKlapSAFIL 126
Cdd:cd17950 3 GFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQL---EPVDGQV---SVLVI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 127 VPSRELCQQV---YTEVSSLIELCRVQLKAVQLTSSMSASDMRNalaGLPEILVSTPACIpkcfAAGVLEPTAVSESLSI 203
Cdd:cd17950 77 CHTRELAFQIsneYERFSKYMPNVKTAVFFGGVPIKKDIEVLKN---KCPHIVVGTPGRI----LALVREKKLKLSHVKH 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 15236218 204 LVLDEADLLLsyGYEDNLRSVTSII---PRRCQCLLMSATTSSDVEKLKKLILHNP 256
Cdd:cd17950 150 FVLDECDKML--EQLDMRRDVQEIFratPHDKQVMMFSATLSKEIRPVCKKFMQDP 203
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
83-240 |
7.85e-15 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 72.05 E-value: 7.85e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 83 GKDVVARAKTGSGKTLAYLLPLLQKLFSAdsvskkklAPSAFILVPSRELCQQVYTEVSSLIelcRVQLKAVQLTSSMSA 162
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLLLLKK--------GKKVLVLVPTKALALQTAERLRELF---GPGIRVAVLVGGSSA 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 163 SDMRNALAGLPEILVSTPACIPKCFAAGVLeptAVSESLSILVLDEADLLLsyGYEDNLRSVTSIIPRR----CQCLLMS 238
Cdd:cd00046 70 EEREKNKLGDADIIIATPDMLLNLLLREDR---LFLKDLKLIIVDEAHALL--IDSRGALILDLAVRKAglknAQVILLS 144
|
..
gi 15236218 239 AT 240
Cdd:cd00046 145 AT 146
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
52-108 |
2.37e-12 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 69.86 E-value: 2.37e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 15236218 52 GLDSRLIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKL 108
Cdd:COG1205 40 WLPPELRAALKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEAL 96
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
72-242 |
7.34e-09 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 55.73 E-value: 7.34e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 72 IQQSAI-PYILEGKDVVARAKTGSGKTLAYLLPLLQKLFSADSVskkklapsAFILVPSRELCQQVYTEVSSLIElcRVQ 150
Cdd:cd17921 5 IQREALrALYLSGDSVLVSAPTSSGKTLIAELAILRALATSGGK--------AVYIAPTRALVNQKEADLRERFG--PLG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 151 LKAVQLTSSMSasdMRNALAGLPEILVSTPACipkcfAAGVL--EPTAVSESLSILVLDEADLLLSYGYEDNLRSVTSII 228
Cdd:cd17921 75 KNVGLLTGDPS---VNKLLLAEADILVATPEK-----LDLLLrnGGERLIQDVRLVVVDEAHLIGDGERGVVLELLLSRL 146
|
170
....*....|....*..
gi 15236218 229 PRR---CQCLLMSATTS 242
Cdd:cd17921 147 LRInknARFVGLSATLP 163
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
73-359 |
1.61e-08 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 57.34 E-value: 1.61e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 73 QQSAI-----PYILEGKDVVARAKTGSGKTlayllpllqkLFSADSVSKKKLAPSAFILVPSRELCQQVYTEVSSLielc 147
Cdd:COG1061 85 QQEALeallaALERGGGRGLVVAPTGTGKT----------VLALALAAELLRGKRVLVLVPRRELLEQWAEELRRF---- 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 148 rvqlkavqLTSSMSASDMRNALAglpEILVSTPACipkcfAAGVLEPTAVSESLSILVLDEADLLLSYGYEDNLRSVTSi 227
Cdd:COG1061 151 --------LGDPLAGGGKKDSDA---PITVATYQS-----LARRAHLDELGDRFGLVIIDEAHHAGAPSYRRILEAFPA- 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 228 iPRRcqcLLMSAT----TSSDVE-----------KLKKLI----LHNPIVLTLTEDNDKEEAVPSNVQQFW---ISCSAQ 285
Cdd:COG1061 214 -AYR---LGLTATpfrsDGREILlflfdgivyeySLKEAIedgyLAPPEYYGIRVDLTDERAEYDALSERLreaLAADAE 289
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15236218 286 DKLLHILALLKLEVVQKKILIFINTIDMGFRLKLFLEKFGIKSAILNGELPQNSRLHILEQFNAGLFDYLIATD 359
Cdd:COG1061 290 RKDKILRELLREHPDDRKTLVFCSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVD 363
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
49-242 |
3.66e-07 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 52.98 E-value: 3.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 49 EELGLDSrLIRALTKKGIEKPTLIQQSAIPY-ILEGKDVVARAKTGSGKTLAYLLPLLQKLFsadsvSKKKlapsAFILV 127
Cdd:COG1204 4 AELPLEK-VIEFLKERGIEELYPPQAEALEAgLLEGKNLVVSAPTASGKTLIAELAILKALL-----NGGK----ALYIV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 128 PSRELCQQVYTEVSSLIElcRVQLKAVQLTSSMSASDmrnALAGLPEILVSTPAcipKcFAAGVLEPTAVSESLSILVLD 207
Cdd:COG1204 74 PLRALASEKYREFKRDFE--ELGIKVGVSTGDYDSDD---EWLGRYDILVATPE---K-LDSLLRNGPSWLRDVDLVVVD 144
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 15236218 208 EADLLlsygyEDNLRSVT-----SIIPRRC---QCLLMSATTS 242
Cdd:COG1204 145 EAHLI-----DDESRGPTlevllARLRRLNpeaQIVALSATIG 182
|
|
| DEXHc_RecQ4-like |
cd18018 |
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ... |
73-245 |
2.05e-06 |
|
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.
Pssm-ID: 350776 [Multi-domain] Cd Length: 201 Bit Score: 48.79 E-value: 2.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 73 QQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLqkLFSADSvskkklapSAFILVpsrelcqqvyteVSSLIELCRVQ-- 150
Cdd:cd18018 17 QEEAIARLLSGRSTLVVLPTGAGKSLCYQLPAL--LLRRRG--------PGLTLV------------VSPLIALMKDQvd 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 151 -----LKAVQLTSSMSASDMRNALAGL-----------PEILVStpacipkcfaAGVLEPTAVSESLSILVLDEADLLLS 214
Cdd:cd18018 75 alpraIKAAALNSSLTREERRRILEKLragevkilyvsPERLVN----------ESFRELLRQTPPISLLVVDEAHCISE 144
|
170 180 190
....*....|....*....|....*....|....*.
gi 15236218 215 YGYE---DNLR--SVTSIIPRRCQCLLMSATTSSDV 245
Cdd:cd18018 145 WSHNfrpDYLRlcRVLRELLGAPPVLALTATATKRV 180
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
301-427 |
4.74e-06 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 49.84 E-value: 4.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 301 QKKILIFINTIDMGFRLKLFLEKFGIKSAILNGELPQNSRLHILEQFNAG----LFdyLIATddnsqtkkqkeEAKGEan 376
Cdd:COG0553 549 GEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGpeapVF--LISL-----------KAGGE-- 613
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 15236218 377 kenkknnkrskpkldaefgvvrGIDFKKVHTVINFDMP-------QSvTGYIHRIGRT 427
Cdd:COG0553 614 ----------------------GLNLTAADHVIHYDLWwnpaveeQA-IDRAHRIGQT 648
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
301-425 |
5.38e-06 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 46.32 E-value: 5.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 301 QKKILIFINTIDMGFRLKLFLEKFGIKSAILNGELPQNSRLHILEQFNAGL--FDYLIATDdnsqtkkqkeeAKGEanke 378
Cdd:cd18793 27 GEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPdiRVFLLSTK-----------AGGV---- 91
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 15236218 379 nkknnkrskpkldaefgvvrGIDFKKVHTVINFDMP-------QSVtGYIHRIG 425
Cdd:cd18793 92 --------------------GLNLTAANRVILYDPWwnpaveeQAI-DRAHRIG 124
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
69-228 |
5.66e-06 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 49.72 E-value: 5.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 69 PTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLFSADsvSKKKLAPSAFIL-----------------VPSRE 131
Cdd:COG1201 25 PTPPQREAWPAIAAGESTLLIAPTGSGKTLAAFLPALDELARRP--RPGELPDGLRVLyisplkalandiernlrAPLEE 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 132 LCQQVYTEVSSLielcRVQLKavqlTSSMSASDMRNALAGLPEILVSTPacipkcfaagvleptavsESLSilvldeadL 211
Cdd:COG1201 103 IGEAAGLPLPEI----RVGVR----TGDTPASERQRQRRRPPHILITTP------------------ESLA--------L 148
|
170
....*....|....*...
gi 15236218 212 LLSY-GYEDNLRSVTSII 228
Cdd:COG1201 149 LLTSpDARELLRGVRTVI 166
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
73-209 |
1.35e-05 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 46.04 E-value: 1.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 73 QQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLFSADSVskkklapSAFILVPSRELCQQVYTEVSSLIELCRVQLK 152
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEALLRDPGS-------RALYLYPTKALAQDQLRSLRELLEQLGLGIR 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15236218 153 AVQLTSSMSASDMRNALAGLPEILVSTPACIpkcfAAGVLEPTAVS----ESLSILVLDEA 209
Cdd:cd17923 78 VATYDGDTPREERRAIIRNPPRILLTNPDML----HYALLPHHDRWarflRNLRYVVLDEA 134
|
|
| DEXHc_RecQ5 |
cd18014 |
DEAH-box helicase domain of RecQ5; ATP-dependent DNA helicase Q5 (RecQ5) is part of the RecQ ... |
72-258 |
1.97e-05 |
|
DEAH-box helicase domain of RecQ5; ATP-dependent DNA helicase Q5 (RecQ5) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350772 [Multi-domain] Cd Length: 205 Bit Score: 45.93 E-value: 1.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 72 IQQSAIPYILEGK-DVVARAKTGSGKTLAYLLPLLqklfsadsVSKKklapSAFILVPSRELCQQvytEVSSLIELcrvQ 150
Cdd:cd18014 17 LQEKATMAVVKGNkDVFVCMPTGAGKSLCYQLPAL--------LAKG----ITIVISPLIALIQD---QVDHLKTL---K 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 151 LKAVQLTSSMSASDMRNALAGLP------EILVSTPACIPKCFAAGVLEPTAVSESLSILVLDEADLLLSYGYE------ 218
Cdd:cd18014 79 IRVDSLNSKLSAQERKRIIADLEsekpqtKFLYITPEMAATSSFQPLLSSLVSRNLLSYLVVDEAHCVSQWGHDfrpdyl 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 15236218 219 --DNLRSVTSIIPrrcqCLLMSATTSSDVEK--LKKLILHNPIV 258
Cdd:cd18014 159 rlGALRSRYGHVP----WVALTATATPQVQEdiFAQLRLKKPVA 198
|
|
| DEXHc_RecQ3 |
cd18017 |
DEAH-box helicase domain of RecQ3; DEAD-like helicase RecQ3 (also called Werner syndrome ... |
82-264 |
6.89e-05 |
|
DEAH-box helicase domain of RecQ3; DEAD-like helicase RecQ3 (also called Werner syndrome ATP-dependent helicase or WRN) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Werner's syndrome.
Pssm-ID: 350775 [Multi-domain] Cd Length: 193 Bit Score: 44.00 E-value: 6.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 82 EGKDVVARAKTGSGKTLAYLLPllqklfsadSVSKKKLapsAFILVPSRELCQ-QVYTEVSSLIElcrvqlkAVQLTSSM 160
Cdd:cd18017 27 ERRDNLVVMATGYGKSLCYQYP---------SVLLNSL---TLVISPLISLMEdQVLQLVMSNIP-------ACFLGSAQ 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 161 SASDMRNALAGLPEILVSTPACIPKcfaaGVLEPTAVSESLSILVLDEADLLLSYGYE--DNLRSVTSIIPRRCQCLLM- 237
Cdd:cd18017 88 SQNVLDDIKMGKIRVIYVTPEFVSK----GLELLQQLRNGITLIAIDEAHCVSQWGHDfrSSYRHLGSIRNRLPNVPIVa 163
|
170 180 190
....*....|....*....|....*....|
gi 15236218 238 -SATTSSDVEK--LKKLILHNPIVLTLTED 264
Cdd:cd18017 164 lTATATPSVRDdiIKNLNLRNPQITCTSFD 193
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
49-240 |
8.71e-05 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 45.58 E-value: 8.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 49 EELGLDSRLIRALTKKGIEKPTLIQQSAIPY-ILEGKDVVARAKTGSGKTLAYLLPLLQKLFsadsvskkKLAPSAFILV 127
Cdd:PRK00254 4 DELRVDERIKRVLKERGIEELYPPQAEALKSgVLEGKNLVLAIPTASGKTLVAEIVMVNKLL--------REGGKAVYLV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 128 PSRELCQQVYTEVSsliELCRVQLKAVQLTSSMSASDmrnALAGLPEILVSTpaciPKCFAAGVLEPTAVSESLSILVLD 207
Cdd:PRK00254 76 PLKALAEEKYREFK---DWEKLGLRVAMTTGDYDSTD---EWLGKYDIIIAT----AEKFDSLLRHGSSWIKDVKLVVAD 145
|
170 180 190
....*....|....*....|....*....|...
gi 15236218 208 EADLLLSYGYEDNLRSVTSIIPRRCQCLLMSAT 240
Cdd:PRK00254 146 EIHLIGSYDRGATLEMILTHMLGRAQILGLSAT 178
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
73-259 |
8.88e-05 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 44.06 E-value: 8.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 73 QQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLqklfsadsvskkKLAPSAFILVPSRELCQ-QVytevsslIELCRVQL 151
Cdd:cd17920 17 QLEAINAVLAGRDVLVVMPTGGGKSLCYQLPAL------------LLDGVTLVVSPLISLMQdQV-------DRLQQLGI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 152 KAVQLTSSMSASDMRNALAGL-----------PEILVStpaciPKCFAAgvLEPTAVSESLSILVLDEADLLL------- 213
Cdd:cd17920 78 RAAALNSTLSPEEKREVLLRIkngqykllyvtPERLLS-----PDFLEL--LQRLPERKRLALIVVDEAHCVSqwghdfr 150
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 15236218 214 -SYGYEDNLRSVTSIIPrrcqCLLMSATTSSDVEK--LKKLILHNPIVL 259
Cdd:cd17920 151 pDYLRLGRLRRALPGVP----ILALTATATPEVREdiLKRLGLRNPVIF 195
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
83-228 |
8.90e-05 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 43.34 E-value: 8.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 83 GKDVVARAKTGSGKTLAYLLPLLQKLFsadsvsKKKLAPSAFILV-PSRELCQQVYTEVSSLIELCRVQLKAVQLTSSMS 161
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSLA------DEPEKGVQVLYIsPLKALINDQERRLEEPLDEIDLEIPVAVRHGDTS 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15236218 162 ASDMRNALAGLPEILVSTPacipkcfaagvleptavsESLSIlvldeadLLLSYGYEDNLRSVTSII 228
Cdd:cd17922 75 QSEKAKQLKNPPGILITTP------------------ESLEL-------LLVNKKLRELFAGLRYVV 116
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
85-312 |
9.93e-05 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 45.11 E-value: 9.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 85 DVVARAKTGSGKTLAYLLPLLQKLfsadsvsKKKLAPSAFILVPSRELCQQVYTEVSSLI--ELCRVQLKAVQLTSSMSA 162
Cdd:cd09639 1 LLVIEAPTGYGKTEAALLWALHSL-------KSQKADRVIIALPTRATINAMYRRAKEAFgeTGLYHSSILSSRIKEMGD 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 163 SD----------MRNALAGLPEILVSTPACIPKCFAAGV--LEPTAVSESLSILVLDEADLLLSYGYEDNLRSVTSIIPR 230
Cdd:cd09639 74 SEefehlfplyiHSNDTLFLDPITVCTIDQVLKSVFGEFghYEFTLASIANSLLIFDEVHFYDEYTLALILAVLEVLKDN 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 231 RCQCLLMSATTSsdvEKLKKLILHNPIVltltEDNDKEEAVPSNVQQFWIsCSAQDKLLHILALLKLEVVQK--KILIFI 308
Cdd:cd09639 154 DVPILLMSATLP---KFLKEYAEKIGYV----EENEPLDLKPNERAPFIK-IESDKVGEISSLERLLEFIKKggSVAIIV 225
|
....
gi 15236218 309 NTID 312
Cdd:cd09639 226 NTVD 229
|
|
| DEXHc_RecQ1 |
cd18015 |
DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ ... |
54-199 |
1.68e-04 |
|
DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350773 [Multi-domain] Cd Length: 209 Bit Score: 43.12 E-value: 1.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 54 DSRLIRAL-TKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLqklfsadsVSKkklapsAFILVPSREL 132
Cdd:cd18015 3 SGKVKDTLkNVFKLEKFRPLQLETINATMAGRDVFLVMPTGGGKSLCYQLPAL--------CSD------GFTLVVSPLI 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 133 cqqvytevsSLIE-----LCRVQLKAVQLTSSMSASDMRNALAGLPE------ILVSTPACIP----------KCFAAGV 191
Cdd:cd18015 69 ---------SLMEdqlmaLKKLGISATMLNASSSKEHVKWVHAALTDknselkLLYVTPEKIAkskrfmskleKAYNAGR 139
|
....*...
gi 15236218 192 LEPTAVSE 199
Cdd:cd18015 140 LARIAIDE 147
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
72-180 |
2.31e-04 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 42.73 E-value: 2.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 72 IQQSAIPYILEG-KDVVARAKTGSGKTLAYLLPLLQkLFSaDSVSKKKLAPSAFILVPSRELCQQVYTEVSSliELCRVQ 150
Cdd:cd18023 5 IQSEVFPDLLYSdKNFVVSAPTGSGKTVLFELAILR-LLK-ERNPLPWGNRKVVYIAPIKALCSEKYDDWKE--KFGPLG 80
|
90 100 110
....*....|....*....|....*....|
gi 15236218 151 LKAVQLTSSMSASDMRNALAGlpEILVSTP 180
Cdd:cd18023 81 LSCAELTGDTEMDDTFEIQDA--DIILTTP 108
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
399-429 |
7.35e-04 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 40.33 E-value: 7.35e-04
10 20 30
....*....|....*....|....*....|.
gi 15236218 399 GIDFKKVHTVINFDMPQSVTGYIHRIGRTGR 429
Cdd:cd18796 107 GIDIGDVDLVIQIGSPKSVARLLQRLGRSGH 137
|
|
| DDXDc_reverse_gyrase |
cd17924 |
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of ... |
67-187 |
9.90e-04 |
|
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350682 [Multi-domain] Cd Length: 189 Bit Score: 40.77 E-value: 9.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 67 EKPTLIQQSAIPYILEGKDVVARAKTGSGKTLaylLPLLQKLFSAdSVSKKKLapsafILVPSRELCQQVYTEVSSLIEL 146
Cdd:cd17924 16 FPPWGAQRTWAKRLLRGKSFAIIAPTGVGKTT---FGLATSLYLA-SKGKRSY-----LIFPTKSLVKQAYERLSKYAEK 86
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 15236218 147 CRVQLKAVQLTSSMSASDMRNALAGLPE----ILVSTPACIPKCF 187
Cdd:cd17924 87 AGVEVKILVYHSRLKKKEKEELLEKIEKgdfdILVTTNQFLSKNF 131
|
|
| DinG |
COG1199 |
Rad3-related DNA helicase DinG [Replication, recombination and repair]; |
80-105 |
2.13e-03 |
|
Rad3-related DNA helicase DinG [Replication, recombination and repair];
Pssm-ID: 440812 [Multi-domain] Cd Length: 629 Bit Score: 41.06 E-value: 2.13e-03
10 20
....*....|....*....|....*.
gi 15236218 80 ILEGKDVVARAKTGSGKTLAYLLPLL 105
Cdd:COG1199 30 LAEGRHLLIEAGTGTGKTLAYLVPAL 55
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
73-204 |
2.32e-03 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 41.02 E-value: 2.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 73 QQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLFSADsvSKKKLAPSAFILV--PSRELCQQVY-------TEVSSL 143
Cdd:PRK13767 37 QRYAIPLIHEGKNVLISSPTGSGKTLAAFLAIIDELFRLG--REGELEDKVYCLYvsPLRALNNDIHrnleeplTEIREI 114
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90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15236218 144 IELCRVQL----KAVQlTSSMSASDMRNALAGLPEILVSTPacipkcfaagvleptavsESLSIL 204
Cdd:PRK13767 115 AKERGEELpeirVAIR-TGDTSSYEKQKMLKKPPHILITTP------------------ESLAIL 160
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| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
398-431 |
3.14e-03 |
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C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 36.91 E-value: 3.14e-03
10 20 30
....*....|....*....|....*....|....
gi 15236218 398 RGIDFKKVHTVINFDMPQSVTGYIHRIGRTGRAY 431
Cdd:cd18785 34 EGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGG 67
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| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
84-209 |
8.64e-03 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 38.02 E-value: 8.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236218 84 KDVVARAKTGSGKTLAYLLPLLQ--KLFSADSVSKKklaPSAFiLVPSRELCQQVYTEVSSLIELcRVQLKAVQLTSSMS 161
Cdd:cd18034 17 RNTIVVLPTGSGKTLIAVMLIKEmgELNRKEKNPKK---RAVF-LVPTVPLVAQQAEAIRSHTDL-KVGEYSGEMGVDKW 91
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90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 15236218 162 ASDMRNALAGLPEILVSTPACIPKCFAAGVLEPtavsESLSILVLDEA 209
Cdd:cd18034 92 TKERWKEELEKYDVLVMTAQILLDALRHGFLSL----SDINLLIFDEC 135
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