|
Name |
Accession |
Description |
Interval |
E-value |
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
5-493 |
0e+00 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 687.43 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 5 QRNTKPPSFSDSTIPVDSDGRATVFRPFSLSSPHSRAFHLAWLSLFSCFFSTFSIPPLVPVISSDLNLSASTVSAAGIAS 84
Cdd:PLN00028 1 QPASPDPKYSKFALPVDSEHKATEFRLFSFARPHMRAFHLSWISFFTCFVSTFAAAPLLPIIRDNLNLTKSDIGNAGIAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 85 FAGSIFSRLAMGPLCDLIGPRTSSAILSFLTAPVILSASLVSSPTSFILVRFFVGFSLANFVANQYWMSSMFSGNVIGLA 164
Cdd:PLN00028 81 VSGSIFSRLAMGPVCDLYGPRYGSAFLLMLTAPAVFCMSLVSSATGFIAVRFFIGFSLATFVSCQYWMSTMFNGKIVGTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 165 NGVSAGWANVGAGISQLLMPLIYSTIAE-FLPRAVAWRVSFVFPAIFQVTTAVLVLLYGQDTPHGNRKNSNQNKLTipee 243
Cdd:PLN00028 161 NGIAAGWGNLGGGVTQLLMPLVFPLIKDaGAPSFTAWRIAFFVPGLLHIIMGILVLTLGQDLPDGNYRELKKSGTM---- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 244 eevlvveedERSSFVEILIGGLGNYRAWILALLYGYSYGVELTTDNVIAGYFYERFGVNLEAAGTIAASFGISNIASRPA 323
Cdd:PLN00028 237 ---------PKDSFSKVLRYGVTNYRTWILALTYGYSFGVELTMDNIIAEYFYDRFGLSLETAGAIAASFGLMNLFARPA 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 324 GGMISDALGKRFGMRGRLWGLWIVQSVAGLLCVLLGRVNSLWGSILVMWVFSVFVQAASGLVFGVVPFVSTRSLGVVAGI 403
Cdd:PLN00028 308 GGYLSDVAARRFGMRGRLWALWIVQTLGGVFCIWLGRANSLGAAIVVMILFSIFVQAACGATFGIVPFVSRRSLGVISGL 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 404 TGSGGTVGAVVTQFLLFSGDDVRKQRSISLMGLMTFVFALSVTSIYFPQWGGMCCGPSSSSEEEDISRGLLVEDEDEEGk 483
Cdd:PLN00028 388 TGAGGNVGAVLTQLLFFTGSSYSTETGISLMGVMIIACTLPVAFIHFPQWGGMFFGPSKDAVEEDYYASEWTEEEKEKG- 466
|
490
....*....|
gi 15241440 484 VVSGSLRPVC 493
Cdd:PLN00028 467 LHQGSLKFAE 476
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
42-447 |
1.26e-115 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 345.78 E-value: 1.26e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 42 FHLAWLSLFSCFFSTFSIPPLVPVISSDLNLSASTVSAAGIASFAGSIFSRLAMGPLCDLIGPR-TSSAILSFLTAPVIL 120
Cdd:cd17341 1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRrVFIASLLLLLIPLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 121 SASLVSSPTSFILVRFFVGFSLANFVANQYWMSSMFSGNVIGLANGVSAGWANVGAGISQLLMPLIYSTIAeFLPRAVAW 200
Cdd:cd17341 81 LALAVSSYWGLLVLGFLLGFAGANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIV-FDGGFVGW 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 201 RVSFVFPAIFQVTTAVLVLLYGQDTPHGNRKNSNqnkltipeeeevlvveederssFVEILIGGLGNYRAWILALLYGYS 280
Cdd:cd17341 160 RNAFFVPGILLAIAAVLVLLFGDDLPTGKASALE----------------------FLKVQLAVLKNYRTWILSLLYGVT 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 281 YGVELTTDNVIAGYFYERFGVNLEAAGTIAASFGISNIASRPAGGMISDalgkRFGMRGRLWGLWIVQSVAGLLCVLLGR 360
Cdd:cd17341 218 FGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSD----RFGGRRRLWWLFIVMTIGAALLSLSLP 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 361 VNS--LWGSILVMWVFSVFVQAASGLVFGVVPFVSTRSLGVVAGITGSGGTVGAVVTQFLLFSGDDVR--KQRSISLMGL 436
Cdd:cd17341 294 TSGtnLVLFLALFVALGLGAGAGNGSVFRMVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTgsGVGAFSLFGV 373
|
410
....*....|.
gi 15241440 437 MTFVFALSVTS 447
Cdd:cd17341 374 LAVACTLLVWL 384
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
40-412 |
2.28e-70 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 227.95 E-value: 2.28e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 40 RAFHLAWLSLFSCFFSTFSIPPLVPV-ISSDLNLSASTVSAAGIASFAGSIFSRLAMGPLCDLIGPR-TSSAILSFLTAP 117
Cdd:TIGR00886 1 RNLFFSWFGFFLSFLVWFAFSPLAVFlIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRyTTALSLLLLAIP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 118 VILSASLVSSPTSFILVRFFVGFSLANFVANQYWMSSMFSGNVIGLANGVSAGWANVGAGISQLLMPLIYSTI--AEFLP 195
Cdd:TIGR00886 81 CLWAGLAVQSYSVLLLIRLFIGIAGGSFASCMPWISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPPIIGSLifGGGQP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 196 RAVAWRVSFVF-PAIFQVTTAVLVLLYGQDTPHGNRKNSnqnkltipeeeevlvveedeRSSFVEILiGGLGNYRAWILA 274
Cdd:TIGR00886 161 AHLAWGWAFVIvPAGILLLPALLIFFVGADTPPGKPATG--------------------KLSFKEAL-KVFGNRHTWILA 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 275 LLYGYSYGVELTTDNVIAGYFYERFGVNLEAAGTIAASFGISNIASRPAGGMISDALGKRfgmrgRLWGLWIVQSVAGLL 354
Cdd:TIGR00886 220 LLYSVTFGSFLGVSSIFAMLFKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGA-----RKLLMNFLGVAMGAF 294
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 355 CVLLGRV--NSLWGSILVMWVFSVFVQAASGLVFGVVPFVSTRSLGVVAGITGSGGTVGA 412
Cdd:TIGR00886 295 LVVLGLVsdGSLAAFIVLFVALFFFAGAGNGSTFALVPHIFRRATGAVSGLIGAIGNLGG 354
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
36-419 |
6.03e-47 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 167.37 E-value: 6.03e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 36 SPHSRAFHLAWLSLFSCFFSTFSIPPLVPVISSDLNLSASTVSAAGIASFAGSIFSRLAMGPLCDLIGPRTSSAILSFLT 115
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 116 APVILSASLVSSPTSFILVRFFVGFSL-ANFVANQYWMSSMFSGNVIGLANGVSAGWANVGAGISQLLMPLIYStiaefl 194
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGgGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIA------ 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 195 prAVAWRVSFVFPAIFQVTTAVLVLLYGQDTPHGNRKNSNQNKLTipeeeevlvveederssfveiLIGGLGNYRAWILA 274
Cdd:COG2223 155 --AFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRD---------------------QLEALRDPRFWLLS 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 275 LLYGYSYGVELTTDNVIAGYFYERFGVNLEAAGTIAASFGISNIASRPAGGMISDALGKRfgmrgrlWGLWIVQSVAGLL 354
Cdd:COG2223 212 LLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGR-------RVLLIVFALMALG 284
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15241440 355 CVLLGRV-NSLWGSILVMWVFSVFVQAASGLVFGVVP-FVSTRSLGVVAGITGSGGTVGAVVTQFLL 419
Cdd:COG2223 285 LLLLALAlGSLWLFLVLFLLLGLALGGGNGAVFALVPdIFPTKNAGAVYGLVGAAGGLGGFLGPLLF 351
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
44-419 |
7.91e-23 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 99.56 E-value: 7.91e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 44 LAWLSLFSCFFSTFSIPPLVPVISSDLNLSASTVSAAGIASFAGSIFSRLAMGPLCDLIGPRTSSAILSFLTAPVILSAS 123
Cdd:COG2271 14 LLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 124 LVSSPTSFILVRFFVGFSLA-NFVANQYWMSSMFSGNVIGLANGVSAGWANVGAGISQLLMPLIYStiaeflprAVAWRV 202
Cdd:COG2271 94 FATSFWQLLLLRFLLGLGEAgFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA--------AFGWRA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 203 SFVFPAIFQVTTAVLVLlygqdtphgnrknsnqnkltipeeeevlvveederssfveiligglgnyraWILALLYGYSYG 282
Cdd:COG2271 166 AFLILGLPGLLLALLRF---------------------------------------------------WLLALAYFLVYF 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 283 VELTTDNVIAGYFYERFGVNLEAAGTIAASFGISNIASRPAGGMISDALGKRfgmrgRLWGLWIVQSVAGLLCVLLGRVN 362
Cdd:COG2271 195 ALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR-----RKLVLAIGLLLAALALLLLALLP 269
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 15241440 363 SLWGSILVMWVFSVFVQAASGLVFGVVP-FVSTRSLGVVAGITGSGGTVGAVVTQFLL 419
Cdd:COG2271 270 SPALAIALLFLAGFGLGGAFGLLWALAAeLFPKKARGTASGLVNTFGFLGGALGPLLV 327
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
40-412 |
8.66e-18 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 84.64 E-value: 8.66e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 40 RAFHLAWLSLFSCFFSTFSIPPLVPVISSDLNLSASTVSAAGIASFAGSIFSRLAMGPLCDLIGPRTSSAILSFLTAPVI 119
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 120 LSASLVSSPTSFILVRFFVGFSLA-NFVANQYWMSSMFSGNVIGLANGVSAGWANVGAGISQLLMPLIYStiaeflprAV 198
Cdd:COG2814 90 LLCALAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD--------LF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 199 AWRVSFVFPAIFQVTTAVLVLLYGQDTPHGNRKNSNQNKLTIpeeeevlvveederssfveiliggLGNYRAWILALLYG 278
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLREL------------------------LRRPRLLLLLLLAF 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 279 YSYGVELTTDNVIAGYFYERFGVNLEAAGTIAASFGISNIASRPAGGMISDALGKRfgmrgrlWGLWIVQSVAGLLCVLL 358
Cdd:COG2814 218 LLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRR-------RLLLIGLLLLALGLLLL 290
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 15241440 359 GRVNSLWGSILVMWVFSVFVQAASGLVFGVVP-FVSTRSLGVVAGITGSGGTVGA 412
Cdd:COG2814 291 ALAGSLWLLLLALFLLGFGFGLLFPLLQALVAeLAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
44-414 |
2.71e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 80.15 E-value: 2.71e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 44 LAWLSLFSCFFSTFSIPPLVPVISSDLNLSASTVSAAGIASFAGSIFSRLAMGPLCDLIGPRTSSAILSFLTAPVILSAS 123
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 124 LVSSPTSFILVRFFVGFSLA-NFVANQYWMSSMFSGNVIGLANGVSAGWANVGAGISQLLMPLIYStiaeflprAVAWRV 202
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS--------LFGWRA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 203 SFVFPAIFQVTTAVLVLLYGQDTPHGNRKNSNQnkltiPEEEEVLVVEEDERSSFVEILIGGLGNYRAWILALLYGYSYG 282
Cdd:pfam07690 153 AFLILAILSLLAAVLLLLPRPPPESKRPKPAEE-----ARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 283 velttdnviagyfyERFGVNLEAAGTIAASFGISNIASRPAGGMISDalgkRFGMRGRLWGLWIVQSVAGLLCVLLGRVN 362
Cdd:pfam07690 228 --------------EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSD----RLGRRRRLLLALLLLILAALGLLLLSLTL 289
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 15241440 363 SLWGSILVMWVFSVFVQAASGLVFGVVP-FVSTRSLGVVAGITGSGGTVGAVV 414
Cdd:pfam07690 290 SSLWLLLALLLLGFGFGLVFPALNALVSdLAPKEERGTASGLYNTAGSLGGAL 342
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
45-419 |
8.26e-13 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 69.57 E-value: 8.26e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 45 AWLSLFSCFFSTFSIPPLVPVISSDLNLSASTVSAAGIASFAGSIFSRLAMGPLCDLIGPRTSSAILSFLTAPVILSASL 124
Cdd:cd17475 1 ATLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 125 VSSPTSFILVRFFVGFSLANFV-ANQYWMSSMFSGNVIGLANGVSAGWANVGAGISQLLMPLIYSTIaeflpravAWRVS 203
Cdd:cd17475 81 VGSYPVLLVLLFLVGAGYGSVQpGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHY--------GWRAA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 204 FVFPAIFQVTTAVLVLLYGQDTPHGNRKNSNQNKLtipeeeEVLVVEEDERSSFVEILIGGlgnyrawilALLYGYSYGV 283
Cdd:cd17475 153 FVVAGLVSILAAVLFWLFYREPPAASAATESASTL------LRSLKEVLRNRDVWLIAIAG---------ALLVAPQFAL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 284 eLTtdnVIAGYFYERFGVNLEAAGTIAASFGISNIASRPAGGMISDALgkRFGMRGRLWGLWIVQSVAGLLCVLLG-RVN 362
Cdd:cd17475 218 -LT---FLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRV--FGGRRRPVLVITAAIAAAALLVLSLLsPGT 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 15241440 363 SLWGSILVMWVFSVFVQAASGLVFG-VVPFVSTRSLGVVAGITGSGGTVGAVVTQFLL 419
Cdd:cd17475 292 PLWLLVLLLILLGLFAIGWNGLYLTlVAESAGPEQAGTALGLANTINFIGIAIGPPLF 349
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
45-419 |
1.80e-12 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 68.61 E-value: 1.80e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 45 AWLSLFSCFFSTFSIPPLVPVISSDLNLSASTVSAAGIASFAGSIFSRLAMGPLCDLIGPRTSSAILSFLTAPVILSASL 124
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 125 VSSPTSFILVRFFVGFSLANFVANQY-WMSSMFSGNVIGLANGVSAGWANVGAGISQLLMPLIYSTIaeflprAVAWRVS 203
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLaLIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSL------GFGWRAV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 204 FVFPAIFQVTTAVLVLLYGQDTPHGNRKNSNQNKLTipeeeevlvveedersSFVEILIGGLGNYRAWILALLYGYSYGV 283
Cdd:cd06174 155 FLIAAALALLAAILLLLVVPDPPESARAKNEEASSK----------------SVLKLLKRVLKNPGLWLLLLAIFLVNLA 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 284 ELTTDNVIAGYFYERFGVNLEAAGTIAASFGISNIASRPAGGMISDalgKRFGMRGRLWGLWIVQSVAGLLCVLLGRVNS 363
Cdd:cd06174 219 YYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSD---RLIGRKPLLLIGLLLMALGLALLLLAPSLLL 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 15241440 364 LWGSILVMWVFSVFVQAASGLVFGVVPFVSTR--SLGVVAGITGSGGTVGAVVTQFLL 419
Cdd:cd06174 296 LLLLLLLLGFGLGGLLPLSFALIAELFPPEIRgtAFGLLNTFGFLGGAIGPLLAGFLL 353
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
64-418 |
9.03e-11 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 63.36 E-value: 9.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 64 PVISSDLNLSASTVSAAGIASFAGSIFSRLAMGPLCDLIGPRTSSAILSFLTAPVILSASLVSSPTSFILVRFFVGFSLA 143
Cdd:cd17319 27 PTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 144 -NFVANQYWMSSMFSGNVIGLANGVSAGWANVGAGISQLLMPLIYSTiaeflpraVAWRVSFVFPAIFQVTTAVLVLLYG 222
Cdd:cd17319 107 gFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLL--------FGWRWAFIIEGLLGLLLAVLWWFYL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 223 QdtphgnrknsnqnkltipeeeevlvveedersSFVEILIGGLGnyrawILALLYGYSYGvelttdnvIAGYFYERFGVN 302
Cdd:cd17319 179 R--------------------------------QVWGLALGYFG-----INYALYGLLTW--------LPTYLKQARGFS 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 303 LEAAGTIAASFGISNIASRPAGGMISDalgkRFGMRGRLWGLWIVQSVAGLLCVLLGRVNSLWGSILVMWVFSVFVQAAS 382
Cdd:cd17319 214 LKQVGLLAAIPFLAGAIGMILGGRLSD----RLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAAS 289
|
330 340 350
....*....|....*....|....*....|....*..
gi 15241440 383 GLVFGVVP-FVSTRSLGVVAGITGSGGTVGAVVTQFL 418
Cdd:cd17319 290 PVFWSLPAdLLPGEAAATAGGLINSGGNLGGFVAPLL 326
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
46-414 |
4.51e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 61.44 E-value: 4.51e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 46 WLSLFSCFFSTFSIPPLVPVISSDLNLSASTVSAAGIASFAGSIFSRLAMGPLCDLIGPRTSSAILSFLTAPVILSASLV 125
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 126 SSPTSFILVRFFVGFSLA-NFVANQYWMSSMFSGNVIGLANGvsagWANVGAGISQLLMPLIYSTIAEFLpravAWRVSF 204
Cdd:cd17325 82 TSYWQLLLARFLQGLASAaVWPAAMALIADIAPPEERGRAMG----IFSSAIGLGFLIGPLLGGLLADAL----GYRAPF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 205 VFPAIFQVTTAVLVLLYGQDTPHGNRKNSNQnkltipeeeevlvveedeRSSFVEILIGGLGNYRAWILALLYGYSYGVE 284
Cdd:cd17325 154 LVCAALALLALVLALLLLPEPRPPPNKRAVS------------------AARLRSGLRLLLRDRRLLALFLAIFVLAFAF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 285 LTTDNVIAGYFYERFGVNLEAAGTIAASFGISNIASRPAGGMISDALGKRFGMrgrLWGLWIVqsvaGLLCVLLGRVNSL 364
Cdd:cd17325 216 GALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLI---LIGLLLS----AVALLLLPLATSF 288
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 15241440 365 WGSILVMWVFSVFVQAASGLVFG-VVPFVSTRSLGVVAGITGSGGTVGAVV 414
Cdd:cd17325 289 WLLLLLLALLGLGLGLVFPATLAlLADIVPPEGRGTAMGLFNTAFSLGMVL 339
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
35-418 |
5.74e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 57.94 E-value: 5.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 35 SSPHSRAFHLAWLSLFSCFFSTFSIPPLVPVISSDLNLSASTVSAAGIASFAGSIFSRLAMGPLCDLIGPRTSSAILSFL 114
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 115 TAPVILSASLVSSPTSFILVRFFVGFSLA--NFVANQYwmssmfsGNVIGLANGVSA-GWANVGAGISQLLMPLIYSTIA 191
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLGLGllDVAANPY-------VAALGPETAASRlNLLHAFFSLGALLGPLLGGLLI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 192 eFLPRAVAWRVSFVFPAIFQVTTAVLVLLYgqdtphgnrknsnqnklTIPEEEEVLVVEEDERSSFVEIliggLGNYRAW 271
Cdd:COG0738 156 -LLGLSLSWHLPYLILAVLLLLLALLFLRS-----------------KLPEIEEEEEEAAGSAASLKSL----LKNPRLL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 272 ILALLYGYSYGVELTTDNVIAGYFYERFGVNLEAAGTIAASFGISNIASRpaggMISDALGKRFGmRGRLWGLWIVQSVA 351
Cdd:COG0738 214 LGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGR----FLGGFLLKRFG-PVRLLRLSALLAAV 288
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15241440 352 GLLCVLL--GRVNSLWGSILVMWVFSVFVQAASGLVFGVVPFVSTRSLGVVAGITGSGGTVGAVVTQFL 418
Cdd:COG0738 289 GLLLALLapGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFL 357
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
35-414 |
1.09e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 54.11 E-value: 1.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 35 SSPHSRAFHLAWLSLFSCFFSTF-------SIPPLVPVISSDLNLSASTVSAAG-IASFAGSIFSrLAMGPLCDLIGPRT 106
Cdd:COG2807 6 SSARRSRRAGRWLLLLAIVLVALnlrpaitSVGPLLPEIRADLGLSATQAGLLTtLPLLAFGLFA-PLAPRLARRFGLER 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 107 SSAILSFLTAPVILSASLVSSPTSFILVRFFVGFSLA-NFVANQYWMSSMFSGNvIGLANGVSAGWANVGAGISqllmpl 185
Cdd:COG2807 85 TLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAvGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALA------ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 186 iySTIAEFLPRAVAWRVSFVFPAIFQVTTAVLVLLYGQDTPHGNRknsnqnkltipeeeevlvveedeRSSFVEILIGGL 265
Cdd:COG2807 158 --AGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAA-----------------------AAPAAASLRSLW 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 266 GNYRAWILALLYGysyGVELTTDNVIA--GYFYERFGVNLEAAGTIAASFGISNIASRPAGGMISDALGKRFGMrgrlwg 343
Cdd:COG2807 213 RSPLAWLLTLFFG---LQSLLYYAVVAwlPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPL------ 283
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15241440 344 lwivqSVAGLLCVLLGRVNSLWGSILVMWVFSVFVQAASGLVFGVVP------FVSTRSLGVVAGITGSGGTVGAVV 414
Cdd:COG2807 284 -----LLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALtliglrARTPAEAAALSGMAQSVGYLLAAL 355
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
57-414 |
2.01e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 52.94 E-value: 2.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 57 FSIPPLVPVISSDLNLSASTVSAAGIASFAGSIFSRLAMGPLCDLIGPRTSSAILSFLTAPVILSASLVSSPTSFILVRF 136
Cdd:cd17324 16 YVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 137 FVGFSLANFVANQY-WMSSMFSGNVIGLANGVSAGwanvGAGISQLLMPLIYSTIAEFLpravAWRVSFVFPAIFQVTTA 215
Cdd:cd17324 96 LAGLAHGGFWAIAAaYAADLVPPEKRGRAIGLVFS----GLTLGLVLGRPLGGLLGQLL----GWRAAFLAIAVLALLAA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 216 VLVLLYGQDTPHGNRKNSNqnkltipeeeevlvveedERSSFVEIliggLGNYRAWILALLYGYSYGVELTTDNVIAGYF 295
Cdd:cd17324 168 LLLWRLLPSLPPKKPGSLG------------------LLSSLLLL----LRNPRLRLAYLITFLLFGGFFALYTYLAPFL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 296 YERFGVNLEAAGTIAASFGISNIASRPAGGMISDalgkRFGMRGRLWGLwIVQSVAGLLCVLLGrvNSLWGSILVMWVFS 375
Cdd:cd17324 226 TDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLAD----RGGRRALLIAL-LLLAAALLLLTLLG--PSPLLLLVGLVLWG 298
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 15241440 376 VFVQAASGLVFGVVPFVSTRSLGVVAGITGS----GGTVGAVV 414
Cdd:cd17324 299 LGFFAAHSALQTRVLRLAPEARGLASSLYLAaynlGGALGAAL 341
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
62-226 |
4.85e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 51.79 E-value: 4.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 62 LVPVISSDLNLSASTVSAAGIASFAGSIFSRLAMGPLCDLIGPRTS--SAILSFLTAPVILSASLVSSPTSFILVRFFVG 139
Cdd:COG2271 203 LPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKlvLAIGLLLAALALLLLALLPSPALAIALLFLAG 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 140 FSLANFVANQY-WMSSMFSGNVIGLANGVSAGWANVGAGISQLLMPLIYStiaeflprAVAWRVSFVFPAIFQVTTAVLV 218
Cdd:COG2271 283 FGLGGAFGLLWaLAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLD--------ATGYQAAFLLLAALALLAALLA 354
|
....*...
gi 15241440 219 LLYGQDTP 226
Cdd:COG2271 355 LLLLRETR 362
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
46-443 |
8.52e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 51.17 E-value: 8.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 46 WLSLFSCFFSTFSIPPLVPVISSDLNLSASTVSAAGIASFAGSIFSRLAMGPLCDLIGPRTSSAILSFLTAPVILSASLV 125
Cdd:cd17333 2 YISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFAT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 126 SSPTSFILVRFFVGFSLANFVAnqywMSSMFSGNVIGLANGVSAGWANVGAGISQLLMPLIystIAEFLPRAVAWRVSFV 205
Cdd:cd17333 82 PSIYLFVVLMFLAGLGAGILDT----GANTFVGALFEESSATRLNVLHGFFGLGALIGPLI---ATSLLTSELSWSWAYL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 206 FPAIFQVTTAVLVLL--YGQDTPHGNRKNSNQNkltipeeeevlvveederssFVEILIGGLGNYRAWILALLYGYSYGV 283
Cdd:cd17333 155 IIGLIYLLLAILILLtlFPELPSARNPQQSVGA--------------------FSASASRLLRNPSIILGALALFLYVGA 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 284 ELTTDNVIAGYFYERFGVNLEAAGTIAASFGISNIASRPAGGMISDALGKRfgmrgRLWGLWIVQSVAGLLCVLL--GRV 361
Cdd:cd17333 215 ETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPH-----TLLVLSGSGALLGLLILLLapTLV 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 362 NSLWGSILVMWVFSVFVQAASGLVFGVVPFVSTRSLGVVAGITGSGGTVGAVVTQFLLFSGDDVRKQRSISLMGLMTFVF 441
Cdd:cd17333 290 VGLVATALLGLFMAALFPTILSLGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVL 369
|
..
gi 15241440 442 AL 443
Cdd:cd17333 370 AL 371
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
59-443 |
9.19e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 51.02 E-value: 9.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 59 IPPLVPVISSDLNLSASTVSAAGIASFAGSIFSRLAMGPLCDLIGPRTSSAILSFLTAPVILSASLVSSPTSFILVRFFV 138
Cdd:cd17477 15 LLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVM 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 139 GFSLA-NFVANQYWMSSMFSGNVIGLANGVSAGWANVGAGISQLLMPLIYSTIAEFlpravawrvsFVFPAIFQVTTAVL 217
Cdd:cd17477 95 GIGLAgLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALP----------FLIAAVLLLLALVP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 218 VLLYGQDTPHGNRKNSnqnkltipeeeevlvveederssfveilIGGLGNYRAWILALLYGYSYGVELTTDNVIAGYFYE 297
Cdd:cd17477 165 LLLTRRAAPEIEEAES----------------------------ISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 298 RFGVNLEAAGTIAASFGISNIASRPAGGMISDALGKRFGMRGrlwglwivQSVAGLLCVLLgrvnslwgsilvmwvfsvf 377
Cdd:cd17477 217 RLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLG--------CALLGALAALL------------------- 269
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15241440 378 vqaasglvfgvVPFVSTRSLGVVAGITGSGGTVGAVVTQFLLFSGDDVRKQRSISLMGLMTFVFAL 443
Cdd:cd17477 270 -----------LPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGL 324
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
42-421 |
1.30e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 50.29 E-value: 1.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 42 FHLAWLSLFSCFFSTFSIPPLVPVISSDLN--LSASTVSAAGIASFAGSIFSRLAMGPLCDLIGPRTSSAILSFLTAPVI 119
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 120 LSASLVSSPTSFILVRFFVGFSL-ANFVANQYWMSSMFSGNVIGLAngvsAGWANVGAGISQLLMPLIYSTIAEFLPRAV 198
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIgGEYPGASTYVAEFAPSKRRGFA----LGLLQSGWALGALLAALVASLLIPLLSGDW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 199 AWRVSFVFPAIFqvttavlvllygqdtphgnrknsnqnkltipeeeevlvveederssfveILIGGLGNYRAWILALLYG 278
Cdd:cd17316 157 GWRILFLIGALP-------------------------------------------------ALLALLLRRRTLLLILLWF 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 279 YSYGVELTTDNVIAGYFYERFGVNLEAAGTIAASFGISNIASRPAGGMISDALGKRFGMrgrLWGLWIvqSVAGLLCVLL 358
Cdd:cd17316 188 FISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTL---VIGLIL--SGILALPLFY 262
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15241440 359 GRVNSLWGSILVMWVFSVFVQAASGLVFGVVP-FVSTRSLGVVAGITGSGGTVGAVVTQFLLFS 421
Cdd:cd17316 263 LLSGSPTLLLLLLFILSFFVGGVWGALYAYLAeLFPTEVRATGVGLSYNLGRLGGGGAPPLIAL 326
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
61-450 |
1.69e-06 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 50.27 E-value: 1.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 61 PLVPVISSDLNLSASTVSAAGIASFAGSIFSRLAMGPLCDLIGPRTssAILSFLTAPVI--LSASLVSSPTSFILVRFFV 138
Cdd:cd17320 20 PALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRP--VLLAGLLLFILasLLCALASSIEQLLIARFLQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 139 GFSLANF-VANQYWMSSMFSG----NVIGLANGVsagwanvgAGISQLLMPLIYSTIAEFLPravaWRVSFVFPAIFQVT 213
Cdd:cd17320 98 GLGAAAGsVVARAIVRDLYSGaelaKIFSLLMMI--------LAIAPALAPLLGGLLLLFFG----WRAIFVFLALLGLL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 214 TAVLVLLYGQDTPHGNRknsnqnkltipeeeevlvvEEDERSSFVEILIGGLGNYRAWILALLYGYSYGVELTTDNVIAG 293
Cdd:cd17320 166 LLLLVLLFLPETLPEEK-------------------RKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPF 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 294 YFYERFGVNLEAAGTIAASFGISNIasrpAGGMISDALGKRFGMRGRLWGLWIVQSVAGLLCVL--LGRVNSLWGSILVM 371
Cdd:cd17320 227 IYIEQLGLSPAQFGLLFALNAIALI----LGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLaaLLGGLSLWPLVAPL 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 372 WVFSVFVQAASGLVFGVVPFVSTRSLGVVAGITGSGGT-VGAVVTQFLLFSGDDvrkqrSISLMGLMTFVFALSVTSIYF 450
Cdd:cd17320 303 FLIFFGFGLIFPNATSLALEPFPHVAGTASALLGFLQFlIGALAGALVGLLPNG-----TALPMGLLILVLGLLALLLLI 377
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
17-179 |
8.89e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 47.66 E-value: 8.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 17 TIPVDSDGRATVFRPFSLSSPHSRAFHLAWLSLFSCFFSTFSIPPLVPVISSD-LNLSASTVSAAGIASFAGSIFSRLAM 95
Cdd:COG2814 184 LLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLA 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 96 GPLCDLIGPRTSSAILSFLTAPVILSASLVSSPTSFILVRFFVGFSL-ANFVANQYWMSSMFSGNVIGLANGVSAGWANV 174
Cdd:COG2814 264 GRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFgLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
....*
gi 15241440 175 GAGIS 179
Cdd:COG2814 344 GGPLA 348
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
35-220 |
9.76e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 47.50 E-value: 9.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 35 SSPHSRAFHLAWLSLFSCFFSTFSIPPLVPVISSDLNLSASTVSAAGIASFAGSIFSRLAMGPLCDLIGPRTSSAILSFL 114
Cdd:COG0477 9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 115 TAPVILSASLVSSPTSFILVRFFVGFSLANFVANQY-WMSSMFSGNVIGLAngvsAGWANVGAGISQLLMPLIYSTIAEF 193
Cdd:COG0477 89 FGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALaLIAELFPARERGRA----LGLWGAAIGLGLALGPLLGGLLVAA 164
|
170 180
....*....|....*....|....*..
gi 15241440 194 LpravAWRVSFVFPAIFQVTTAVLVLL 220
Cdd:COG0477 165 L----GWRWIFLINAPLGLLALVLRLR 187
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
46-412 |
5.67e-05 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 45.44 E-value: 5.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 46 WLSLFSCFFSTFSIPPLVPVISSDLNLSASTVSAAGIASFAGSIFSRLAMGPLCDLIGPRTSSAILSFLTAPVILSASLV 125
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 126 SSPTSFILVRFFVG-FSLANFVANQYWMSSMFSGNVIGLANGVSAGWANVGAGIsqlLMPLIYSTIAEFLpravAWRVSF 204
Cdd:TIGR00881 81 TSLWVMAALWALNGiFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGL---LPPLVLFGIAELY----SWHWVF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 205 VFPAIFQVTTAVLVLLYGQDTPHgNRKNSNQNKLTIPEEEEVLVVEEDERSSFVEILIGGLGNYRAWILALLYGYSYGVE 284
Cdd:TIGR00881 154 IVPGIIAIIVSLICFLLLRDSPQ-SCGLPPAEEMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVR 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 285 LTTDNVIAGYFYERFGVNLEAAGTIAASFGISNIASRPAGGMISDAL--GKRFGMrgrlwglwIVQSVAGLLCVLLGRVN 362
Cdd:TIGR00881 233 TGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLfnGRRGPL--------AVFFMALIIVSLLVYWL 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 15241440 363 SLWGSILVMWVFSVfvqAASGLVFG--------VVPFVSTRSLGVVAGITGSGGTVGA 412
Cdd:TIGR00881 305 NPAANPLMDLICLF---ALGFLVYGpqmligviASELAPKKAAGTAAGFVGFFAYLGG 359
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
50-220 |
3.74e-04 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 42.56 E-value: 3.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 50 FSCFFSTFS---IPPLVPVISSDLNLSASTVSAAGIASFAGSIFSRLAMGPLCDLIGpRTSSAILSFLTApVILSASLVS 126
Cdd:cd17323 6 FLTFVVTFGssiYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYG-RRPVYLVSLFIF-VIFQIGCAL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 127 SPT--SFILVRFFVGFSLANFVAN-QYWMSSMFSGNVIGLANGVSAGWANVGAGISqllmPLIYSTIAEFLPravaWRVS 203
Cdd:cd17323 84 APNiaMLIILRFLQGFFGSSPLAIgAGTIADLFTPEERGKAMGVYSLGPLLGPALG----PIIGGFITQSLG----WRWI 155
|
170
....*....|....*..
gi 15241440 204 FVFPAIFQVTTAVLVLL 220
Cdd:cd17323 156 FWFLAIISGFCLILIFL 172
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
267-453 |
3.78e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 42.92 E-value: 3.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 267 NYRAWILALLYGY-SYGVELTTDNVIAGYFYERFGVNLEAAGTIAASFGISNIASRPAGGMISDALGKRFGMrgrLWGLW 345
Cdd:COG0738 5 NYRRALIAIYLLFfLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGL---LLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 346 IVqsvaGLLCVLLGRVNSLWGSILVMWVFSV---FVQAASG-LVFGVVPFVSTRSLGVVAGITGSGGTVGAVVTQFLLFS 421
Cdd:COG0738 82 LM----ALGLLLFALAPSYPLLLLALFLLGLglgLLDVAANpYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILL 157
|
170 180 190
....*....|....*....|....*....|..
gi 15241440 422 GDDVRKQRSISLMGLMTFVFALSVTSIYFPQW 453
Cdd:COG0738 158 GLSLSWHLPYLILAVLLLLLALLFLRSKLPEI 189
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
59-221 |
4.43e-04 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 42.62 E-value: 4.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 59 IPPLVPVISSDLNLSASTVSAAGIASFAGSIFSRLAMGPLCDLIGPRTSSAILSFLTAPVILSASLVSSPTSFILVRFFV 138
Cdd:PRK15402 32 IQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQ 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 139 GFSLANFVANQY-WMSSMFSGNViglANGVSAGWANVgAGISQLLMPLIYSTIAEFLPravaWRVSFVFPAIfqVTTAVL 217
Cdd:PRK15402 112 GIGLCFIGAVGYaAIQESFEEAD---AIKITALMANV-ALLAPLLGPLVGAALIHVLP----WRGMFVLFAA--LAALSF 181
|
....
gi 15241440 218 VLLY 221
Cdd:PRK15402 182 FGLW 185
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
44-189 |
5.48e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 42.20 E-value: 5.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 44 LAWLSLFSCFFSTFSIPPLVPVI-SSDLNLSASTVSAAGIASFAGSIFSRLAMGPLCDLIGPRTS---SAILSFLTAPVI 119
Cdd:cd17316 181 LLILLWFFISFGYYGLTTFLPTYlQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTlviGLILSGILALPL 260
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 120 LSASLVSSPTSFILVRFFVGFSLANFVANQYWMSSMFSGNVIGLANGVSAGWANVGAGISQLLMPLIYST 189
Cdd:cd17316 261 FYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAS 330
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
57-412 |
7.91e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 41.87 E-value: 7.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 57 FSIPPLVPVISSDLNLSASTVSAAGIASFAGSIFSRLAMGPLCDLIGPRTSSAILSFLTAPVILSASLVSSPTSFILVRF 136
Cdd:cd17355 20 YYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 137 FVGFSLANFVAnqYWMSSMFSGNVIGLANGVSAGWANVGAGISQLLMPLIYSTIAEFLPravaWRVSFVFPAIFQVTTAV 216
Cdd:cd17355 100 LLGGGGAGTLA--AVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFG----WRTALLVLALLALLVLV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 217 LVLLYGqdtphgnrknsnqnkLTIPEEEEVLVVEEDERSSFVEILIGGLGNYRAWILALLYGYS-YGVELTTDNVIAgyF 295
Cdd:cd17355 174 PVLLLL---------------RRRPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCgFAVVGLIVHLVP--Y 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 296 YERFGVNLEAAGTIAASFGISNIASRPAGGMISDALGKRfgmrgRLWGLWIVQSVAGLLCVLLGRvnslwGSILVMWVFS 375
Cdd:cd17355 237 LADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPR-----RLLAASYALRALGLALLLLLP-----FPPLALLLFA 306
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 15241440 376 VFVQAASG-----LVFGVVPFVSTRSLGVVAGITGSGGTVGA 412
Cdd:cd17355 307 ALFGLGWGatvplTAALAARYFGARSYGTLFGLVFAPHQLGS 348
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
56-209 |
8.79e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 41.52 E-value: 8.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 56 TFSIPPLVPVISSDLNLSASTVSAAGIASFAGSIFSrlamGPLCDLIGpRTSSAILSFLTAPVI-LSASLVSSPTSFILV 134
Cdd:cd17371 19 GLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILG----GILADRFG-RVRVLVITILLFAVFtLLCGFAQNYWQLLIL 93
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15241440 135 RFFVGFSLA-NFVANQYWMSSMFSGNVIGLANG-VSAGWAnVGAGISQLLMPLIYStiaeFLPRAVAWRVSFVFPAI 209
Cdd:cd17371 94 RALAGLGFGgEWAAGAALMAEYVPARHRGKALGyVQSGWA-VGWLLATLLAALLFP----LLPPEIAWRVLFLLGAL 165
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
38-415 |
1.04e-03 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 41.22 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 38 HSRAFHLAWLSLFSC--FFSTFSIPPLVPVISSDLNLSASTVSAAGIASFAGSIFSRLAMGPLCDLIGPRTSSAILSFLT 115
Cdd:TIGR00710 1 KSAKAFALLLGCLSIlgPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 116 APVILSASLVSSPTSFILVRFFVGFSL-ANFVANQYWMSSMFSGNVIGLANGVSAGWanvgAGISQLLMPLIYSTIAEFL 194
Cdd:TIGR00710 81 ALSSLGLALSNNIETLLVLRFVQAFGAsAGSVISQALVRDIYPGEELSRIYSILMPV----LALAPAVAPLLGGYILVWL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 195 pravAWRVSFvfpAIFQVTTAVLVLLYGQDTPHGNRKNSNQnkltipeeeevlvveedERSSFVEILIGGLGNYRAWILA 274
Cdd:TIGR00710 157 ----SWHAIF---AFLSLAGILLSALIFFILPETLPYEARI-----------------QISTYFETFLLLLKSKMFWGYA 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 275 LLYGYSYGVELTTDNVIAGYFYERFGVNLEAAGTiaaSFGISNIASRPAGGMISDALGKRFGMRGRLWGLWI-VQSVAGL 353
Cdd:TIGR00710 213 LIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGL---LFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILfAVSAVLL 289
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15241440 354 LCVLLGRVNSLWGSILVMWvfsvFVQAASGLVFGVVPFVSTRSLGVVAGITGS-----GGTVGAVVT 415
Cdd:TIGR00710 290 EITAILGLGSWAMIIGPMM----FVGIGNSMISSIAMAYALEDFPHVAGTASAlfgtlRLVLGAIVG 352
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
58-413 |
1.43e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 41.00 E-value: 1.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 58 SIPPLVPVISSDLNLSASTVSAAGIASFAGSIFSRLAMGPLCDLIGPRTSSAILSFLTAPVILSASLVSSPTSFILVRFF 137
Cdd:cd17478 14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 138 VGFSLANFVANQYWMSSMFSGNVIGLANGVSAGWANVGAGISQLLMPLIYSTIaeFLPRAVAWrvsFVFPAIFqvtTAVL 217
Cdd:cd17478 94 AGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALF--GGLGLLIL---LIIPGLA---VALL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 218 VLLYGQDTPHGNRKNSNQNKLTIPEEEEVlvveederssFVEILIGGLGNYRAWILALLygysygvelttdNVIAGYFYE 297
Cdd:cd17478 166 LLRLRPLKKPEAKKAAAKSSARSTLKGVW----------RALLLLLIIVFLRSWVLSSL------------TTFLPFYLV 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 298 RFGVNLEAAGTIAASFGISNIASRPAGGMISDALGKRFGMrgrlwglwIVQSVAGLLCVLLGRVNSLWGSILVMWVFSVF 377
Cdd:cd17478 224 QRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVI--------IASLLLAAPFLLLFLLTPGIWSYILLVLAGFL 295
|
330 340 350
....*....|....*....|....*....|....*..
gi 15241440 378 VQAASGLVFGVVPFVSTRSLGVVAGIT-GSGGTVGAV 413
Cdd:cd17478 296 LFASFPVTVVLAQELLPGNVGLASGLMmGLSFGLGGI 332
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
53-220 |
2.13e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 40.27 E-value: 2.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 53 FFSTFSIP-PLVPVISSDLNLSASTVSAAGIASFAGSIFSRLAMGPLCDLIGPRTSSAILSFLTAPVILSASLVSSPTSF 131
Cdd:cd17489 8 FFLSFYLLlPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 132 ILVRFFVGFSLANFVAnqywMSSMFSGNVIGLAN-GVSAGWANVGAGISQLLMPLIYSTIAEFLpravAWRVSFVFPAIF 210
Cdd:cd17489 88 LVLRLIHGIGWGAFTT----AAATLVADIIPPSRrGEGIGYYGLATTLAMALGPALGLFLYQHL----GFAVLFIVAAVL 159
|
170
....*....|
gi 15241440 211 QVTTAVLVLL 220
Cdd:cd17489 160 ALLALLLVFL 169
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
24-179 |
2.14e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.09 E-value: 2.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 24 GRATVFRPFSLSSPHSRAFHLAWLSLFSCFFSTFSIPPLVPVISSDLNLSASTVSAAGIASFAGSIFSRLAMGPLCDLIG 103
Cdd:pfam07690 184 EEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLG 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 104 PRTS---SAILSFLTAPVILSASLVSSPTSFILVRFFVGFSLA-NFVANQYWMSSMFSGNVIGLANGVSAGWANVGAGIS 179
Cdd:pfam07690 264 RRRRlllALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGlVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
39-182 |
3.50e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 39.65 E-value: 3.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 39 SRAFHLAWLSLFSCFFSTFSIPPLVPVISSDLNLSASTVSAAGIASFAGSIFSRLAMGPLCDLIGPRTSSAILSFLTAPV 118
Cdd:TIGR00895 249 ARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFA 328
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15241440 119 ILSASLVSSPTSFILVRFFVG-FSLANFVANQYWMSSMFSGNVIGLANGVSAGWANVGAGISQLL 182
Cdd:TIGR00895 329 VLVGSTLFSPTLLLLLGAIAGfFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPIL 393
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
57-389 |
4.09e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 39.53 E-value: 4.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 57 FSIPPLVPVISSDLNLSAStvsAAGIASFAgSIFSRLAMGPLCDLIGPRTSSAIL----SFLTAPVILSASLVSSPTSFI 132
Cdd:cd17328 16 FTIAGVLPDIQSDFLIDDS---LAGLLQTV-FIISYMVLSPIFGYLGDRYNRKWIlavgILIWSAATLLSSFAPNFWQLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 133 LVRFFVGFSLANFV-ANQYWMSSMFSGNVIGLANGVSAGWANVGAGISQLLMPLIYSTIAEflpravaWRVSFVFPAIFQ 211
Cdd:cd17328 92 LFRALVGIGEASYSpIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGG-------WRWAFRVTGVLG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 212 VTTAVLVLLYGQDTPHGNRKNSNQNKLTIPEEEEVLVVEEDERsSFVEILIGG------LGNYRAWILALLYgYSYGVEL 285
Cdd:cd17328 165 VLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKALAKNP-SFILSTLGFtavsfvTGALAFWAPTFFL-RAFGVGD 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 286 TTDNVIAGYFyerfgvnleaaGTIAASFGIsniasrpAGGMISDALGKRFGMRGRLWGLWIVQ--SVAGLLCVLLGRVNS 363
Cdd:cd17328 243 LSSADVGLIF-----------GAITCIAGV-------LGVLLGGILADRLRRKTPRADPLVCAvgLLAAAPFLFLALVLA 304
|
330 340 350
....*....|....*....|....*....|
gi 15241440 364 LwGSILVMWVF----SVFVQAASGLVFGVV 389
Cdd:cd17328 305 L-SNLLLAWVLlflgEFLLSLNWAPVFAIL 333
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
266-419 |
5.57e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 39.08 E-value: 5.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 266 GNYRAWILALL---YGYSYGVELTTdNVIAGYFYERFGVNLEAAGTIAASFGISNIASRPAGGMISDALGKRFGMrgrLW 342
Cdd:COG2271 5 SRYRWRILALLflaYFLNYLDRSNL-SVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVL---AI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 343 GLWIvqsvAGLLCVLLGRVNSLWgsilVMWVFSVFVQAASGLVFGVVP-----FVSTRSLGVVAGITGSGGTVGAVVTQF 417
Cdd:COG2271 81 GLLL----WGLATLLFGFATSFW----QLLLLRFLLGLGEAGFFPAALkliaeWFPPKERGRALGIFNAGGPLGGALAPP 152
|
..
gi 15241440 418 LL 419
Cdd:COG2271 153 LL 154
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
39-189 |
9.93e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 38.32 E-value: 9.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241440 39 SRAFHLAWLSLFSCFFSTFSIPPLVPVISSDlNLSASTVSAAGIASFAG--SIFSRLAMGPLCDLIGP-RTSSAILSFLT 115
Cdd:COG2223 204 DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVD-QFGLSAATAGLLAALFAllGALGRPLGGWLSDRIGGrRVLLIVFALMA 282
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15241440 116 APVILSASLVSSPTSFILVRFFVGFSL-ANFVANQYWMSSMFSGNVIGLANGVSAGWANVGAGISQLLMPLIYST 189
Cdd:COG2223 283 LGLLLLALALGSLWLFLVLFLLLGLALgGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDA 357
|
|
| |
