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Conserved domains on  [gi|15238021|ref|NP_197275|]
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P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 223-377 3.64e-71

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


:

Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 222.23  E-value: 3.64e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 223 VMGDLDRFIRRKDFYKRVGKPWKRGYLLYGPPGTGKTSLVAAIANYLKFDIYDLQLASVREDADLRRLLLGTT-NSSILL 301
Cdd:cd19510   1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEVVLTDDRLNHLLNTApKQSIIL 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15238021 302 VEDIDCAVDLHtRLQPKTQDDTKGSSMLTLSGLLTCIDGLWSScgDERIVIFTTTHKERLDPALLRPGRMDMHIHM 377
Cdd:cd19510  81 LEDIDAAFESR-EHNKKNPSAYGGLSRVTFSGLLNALDGVASS--EERIVFMTTNHIERLDPALIRPGRVDMKIYM 153
AAA_assoc pfam14363
Domain associated at C-terminal with AAA; This domain is found in association with the AAA ...
 35-129 1.76e-22

Domain associated at C-terminal with AAA; This domain is found in association with the AAA family, pfam00004.


:

Pssm-ID: 464152  Cd Length: 95  Bit Score: 91.46  E-value: 1.76e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021    35 IPPPLQNYMISYLNSFLHSTPSTLTLIIDDhIKNGMYNELYGAAQVYISTKVNHNAER-LRISRDRSEKNVNIHFSVGEV 113
Cdd:pfam14363   1 LPPELRDYLSSKLARLFSRFSPYLTIVIDE-FDGFSRNELYDAAQTYLSTKISPSSARrLKASKSPKSKSLVLSLDDNEE 79

                          90
                  ....*....|....*.
gi 15238021   114 VSDIYQGIEVKWRFCV 129
Cdd:pfam14363  80 VTDVFEGVKLWWTLVV 95
PRK08939 super family cl35750
primosomal protein DnaI; Reviewed
 161-270 1.76e-03

primosomal protein DnaI; Reviewed


The actual alignment was detected with superfamily member PRK08939:

Pssm-ID: 236353 [Multi-domain]  Cd Length: 306  Bit Score: 40.24  E-value: 1.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021  161 HTELVLNSY---IPYVESKAKVINNERKILKMysyccmylKWQSVNLE---HPSTFDTMAMNEELKRSVMGDLDRFIRRk 234
Cdd:PRK08939  79 QPKLVMNGGyidVSYLPTPEKIEADEEKAIKK--------RIQSIYMPkdlLQASLADIDLDDRDRLDALMAALDFLEA- 149

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 15238021  235 dfYKRvgKPWKRGYLLYGPPGTGKTSLVAAIANYLK 270
Cdd:PRK08939 150 --YPP--GEKVKGLYLYGDFGVGKSYLLAAIANELA 181
 
Name Accession Description Interval E-value
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 223-377 3.64e-71

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 222.23  E-value: 3.64e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 223 VMGDLDRFIRRKDFYKRVGKPWKRGYLLYGPPGTGKTSLVAAIANYLKFDIYDLQLASVREDADLRRLLLGTT-NSSILL 301
Cdd:cd19510   1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEVVLTDDRLNHLLNTApKQSIIL 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15238021 302 VEDIDCAVDLHtRLQPKTQDDTKGSSMLTLSGLLTCIDGLWSScgDERIVIFTTTHKERLDPALLRPGRMDMHIHM 377
Cdd:cd19510  81 LEDIDAAFESR-EHNKKNPSAYGGLSRVTFSGLLNALDGVASS--EERIVFMTTNHIERLDPALIRPGRVDMKIYM 153
AAA_assoc pfam14363
Domain associated at C-terminal with AAA; This domain is found in association with the AAA ...
 35-129 1.76e-22

Domain associated at C-terminal with AAA; This domain is found in association with the AAA family, pfam00004.


Pssm-ID: 464152  Cd Length: 95  Bit Score: 91.46  E-value: 1.76e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021    35 IPPPLQNYMISYLNSFLHSTPSTLTLIIDDhIKNGMYNELYGAAQVYISTKVNHNAER-LRISRDRSEKNVNIHFSVGEV 113
Cdd:pfam14363   1 LPPELRDYLSSKLARLFSRFSPYLTIVIDE-FDGFSRNELYDAAQTYLSTKISPSSARrLKASKSPKSKSLVLSLDDNEE 79

                          90
                  ....*....|....*.
gi 15238021   114 VSDIYQGIEVKWRFCV 129
Cdd:pfam14363  80 VTDVFEGVKLWWTLVV 95
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 248-378 2.19e-21

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 89.57  E-value: 2.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021   248 YLLYGPPGTGKTSLVAAIANYLKFDIYDLQLASVRE------DADLRRLL--LGTTNSSILLVEDIDcavdlhtRLQPKT 319
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSkyvgesEKRLRELFeaAKKLAPCVIFIDEID-------ALAGSR 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 15238021   320 QDDTKGSSMLTLSGLLTCIDGLwSSCGDERIVIFTTTHKERLDPALLrpGRMDMHIHMG 378
Cdd:pfam00004  74 GSGGDSESRRVVNQLLTELDGF-TSSNSKVIVIAATNRPDKLDPALL--GRFDRIIEFP 129
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 196-376 6.83e-21

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 93.15  E-value: 6.83e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 196 YLKWQSVNLEHPS-TFDTMAMNEELKRSVMGDLDRFIRRKDFYKRVGKPWKRGYLLYGPPGTGKTSLVAAIANYLKFDIY 274
Cdd:COG1222  62 TPRGTAVPAESPDvTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFI 141

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 275 DLQLASVR-----EDADLRRLLLGTTNS---SILLVEDIDcAVdLHTRlqpkTQDDTKGSSMLTLSGLLTCIDGlWSSCG 346
Cdd:COG1222 142 RVRGSELVskyigEGARNVREVFELAREkapSIIFIDEID-AI-AARR----TDDGTSGEVQRTVNQLLAELDG-FESRG 214

                       170       180       190
                ....*....|....*....|....*....|
gi 15238021 347 DERIvIFTTTHKERLDPALLRPGRMDMHIH 376
Cdd:COG1222 215 DVLI-IAATNRPDLLDPALLRPGRFDRVIE 243
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 209-378 5.18e-13

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 71.48  E-value: 5.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021   209 TFDTMAMNEELKRSVMGDLDRFIRRKDFYKRVGKPWKRGYLLYGPPGTGKTSLVAAIANYLKFDIYDLQLASV------R 282
Cdd:TIGR01243 176 TYEDIGGLKEAKEKIREMVELPMKHPELFEHLGIEPPKGVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEImskyygE 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021   283 EDADLRRLLLGTTNS--SILLVEDIDCavdlhtrLQPKTQDDTKGSSMLTLSGLLTCIDGLwsscgDER---IVIFTTTH 357
Cdd:TIGR01243 256 SEERLREIFKEAEENapSIIFIDEIDA-------IAPKREEVTGEVEKRVVAQLLTLMDGL-----KGRgrvIVIGATNR 323

                         170       180
                  ....*....|....*....|.
gi 15238021   358 KERLDPALLRPGRMDMHIHMG 378
Cdd:TIGR01243 324 PDALDPALRRPGRFDREIVIR 344
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 233-375 4.30e-12

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 67.87  E-value: 4.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021  233 RKDFYKRVG-KPWKrGYLLYGPPGTGKTSLVAAIAN-----YLKFDIYDLQLASVREDADLRRLL--LGTTNS-SILLVE 303
Cdd:PTZ00361 205 HPELYDDIGiKPPK-GVILYGPPGTGKTLLAKAVANetsatFLRVVGSELIQKYLGDGPKLVRELfrVAEENApSIVFID 283

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15238021  304 DIDCavdlhtrLQPKTQDDTKGSS---MLTLSGLLTCIDGlWSSCGDERiVIFTTTHKERLDPALLRPGRMDMHI 375
Cdd:PTZ00361 284 EIDA-------IGTKRYDATSGGEkeiQRTMLELLNQLDG-FDSRGDVK-VIMATNRIESLDPALIRPGRIDRKI 349
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 245-378 1.19e-07

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 50.83  E-value: 1.19e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021    245 KRGYLLYGPPGTGKTSLVAAIANYLKFDIYDLQL--ASVREDADLRRLLLGTTNSSILLVEDIDCAVDLHTRLQPKTQD- 321
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPGGGVIYidGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPDv 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15238021    322 ---------DTKGSSMLTLSGLLTCIDGLWSSCGDeRIVIFTTTHKERLDPALLRPgRMDMHIHMG 378
Cdd:smart00382  82 lildeitslLDAEQEALLLLLEELRLLLLLKSEKN-LTVILTTNDEKDLGPALLRR-RFDRRIVLL 145
PRK08939 PRK08939
primosomal protein DnaI; Reviewed
 161-270 1.76e-03

primosomal protein DnaI; Reviewed


Pssm-ID: 236353 [Multi-domain]  Cd Length: 306  Bit Score: 40.24  E-value: 1.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021  161 HTELVLNSY---IPYVESKAKVINNERKILKMysyccmylKWQSVNLE---HPSTFDTMAMNEELKRSVMGDLDRFIRRk 234
Cdd:PRK08939  79 QPKLVMNGGyidVSYLPTPEKIEADEEKAIKK--------RIQSIYMPkdlLQASLADIDLDDRDRLDALMAALDFLEA- 149

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 15238021  235 dfYKRvgKPWKRGYLLYGPPGTGKTSLVAAIANYLK 270
Cdd:PRK08939 150 --YPP--GEKVKGLYLYGDFGVGKSYLLAAIANELA 181
 
Name Accession Description Interval E-value
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 223-377 3.64e-71

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 222.23  E-value: 3.64e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 223 VMGDLDRFIRRKDFYKRVGKPWKRGYLLYGPPGTGKTSLVAAIANYLKFDIYDLQLASVREDADLRRLLLGTT-NSSILL 301
Cdd:cd19510   1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEVVLTDDRLNHLLNTApKQSIIL 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15238021 302 VEDIDCAVDLHtRLQPKTQDDTKGSSMLTLSGLLTCIDGLWSScgDERIVIFTTTHKERLDPALLRPGRMDMHIHM 377
Cdd:cd19510  81 LEDIDAAFESR-EHNKKNPSAYGGLSRVTFSGLLNALDGVASS--EERIVFMTTNHIERLDPALIRPGRVDMKIYM 153
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 232-376 9.83e-26

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 102.75  E-value: 9.83e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 232 RRKDFYKRVGKPWKRGYLLYGPPGTGKTSLVAAIANYLKFDIYDLQLASVRE------DADLRRL--LLGTTNSSILLVE 303
Cdd:cd19481  13 RRGSRLRRYGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSkyvgesEKNLRKIfeRARRLAPCILFID 92

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15238021 304 DIDCAvdlhtrlqPKTQDDTKGSSML--TLSGLLTCIDGLwssCGDERIVIF-TTTHKERLDPALLRPGRMDMHIH 376
Cdd:cd19481  93 EIDAI--------GRKRDSSGESGELrrVLNQLLTELDGV---NSRSKVLVIaATNRPDLLDPALLRPGRFDEVIE 157
AAA_assoc pfam14363
Domain associated at C-terminal with AAA; This domain is found in association with the AAA ...
 35-129 1.76e-22

Domain associated at C-terminal with AAA; This domain is found in association with the AAA family, pfam00004.


Pssm-ID: 464152  Cd Length: 95  Bit Score: 91.46  E-value: 1.76e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021    35 IPPPLQNYMISYLNSFLHSTPSTLTLIIDDhIKNGMYNELYGAAQVYISTKVNHNAER-LRISRDRSEKNVNIHFSVGEV 113
Cdd:pfam14363   1 LPPELRDYLSSKLARLFSRFSPYLTIVIDE-FDGFSRNELYDAAQTYLSTKISPSSARrLKASKSPKSKSLVLSLDDNEE 79

                          90
                  ....*....|....*.
gi 15238021   114 VSDIYQGIEVKWRFCV 129
Cdd:pfam14363  80 VTDVFEGVKLWWTLVV 95
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 248-378 2.19e-21

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 89.57  E-value: 2.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021   248 YLLYGPPGTGKTSLVAAIANYLKFDIYDLQLASVRE------DADLRRLL--LGTTNSSILLVEDIDcavdlhtRLQPKT 319
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSkyvgesEKRLRELFeaAKKLAPCVIFIDEID-------ALAGSR 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 15238021   320 QDDTKGSSMLTLSGLLTCIDGLwSSCGDERIVIFTTTHKERLDPALLrpGRMDMHIHMG 378
Cdd:pfam00004  74 GSGGDSESRRVVNQLLTELDGF-TSSNSKVIVIAATNRPDKLDPALL--GRFDRIIEFP 129
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 196-376 6.83e-21

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 93.15  E-value: 6.83e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 196 YLKWQSVNLEHPS-TFDTMAMNEELKRSVMGDLDRFIRRKDFYKRVGKPWKRGYLLYGPPGTGKTSLVAAIANYLKFDIY 274
Cdd:COG1222  62 TPRGTAVPAESPDvTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFI 141

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 275 DLQLASVR-----EDADLRRLLLGTTNS---SILLVEDIDcAVdLHTRlqpkTQDDTKGSSMLTLSGLLTCIDGlWSSCG 346
Cdd:COG1222 142 RVRGSELVskyigEGARNVREVFELAREkapSIIFIDEID-AI-AARR----TDDGTSGEVQRTVNQLLAELDG-FESRG 214

                       170       180       190
                ....*....|....*....|....*....|
gi 15238021 347 DERIvIFTTTHKERLDPALLRPGRMDMHIH 376
Cdd:COG1222 215 DVLI-IAATNRPDLLDPALLRPGRFDRVIE 243
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 237-375 1.74e-18

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 82.34  E-value: 1.74e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 237 YKRVGKPWKRGYLLYGPPGTGKTSLVAAIANYLKFDIYDLQLASV------REDADLRRLLLGTTNS--SILLVEDIDCa 308
Cdd:cd19503  26 FRALGLKPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIvskylgESEKNLREIFEEARSHapSIIFIDEIDA- 104

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15238021 309 vdlhtrLQPKTQDDTKGSSMLTLSGLLTCIDGLWSScgDERIVIFTTTHKERLDPALLRPGRMDMHI 375
Cdd:cd19503 105 ------LAPKREEDQREVERRVVAQLLTLMDGMSSR--GKVVVIAATNRPDAIDPALRRPGRFDREV 163
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 210-376 1.87e-18

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 86.89  E-value: 1.87e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 210 FDTMAMNEELKRSVMGDLDRFIRRKDFYKRVGKPWKRGYLLYGPPGTGKTSLVAAIANYLKFDIYDLQLASVR------- 282
Cdd:COG0464 156 LDDLGGLEEVKEELRELVALPLKRPELREEYGLPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVskyvget 235

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 283 EDAdLRRLL---LGTTNsSILLVEDIDcAVdlhtrLQPKTQDDTKGSSMLtLSGLLTCIDGLwsscGDERIVIFTTTHKE 359
Cdd:COG0464 236 EKN-LREVFdkaRGLAP-CVLFIDEAD-AL-----AGKRGEVGDGVGRRV-VNTLLTEMEEL----RSDVVVIAATNRPD 302

                       170
                ....*....|....*..
gi 15238021 360 RLDPALLRpgRMDMHIH 376
Cdd:COG0464 303 LLDPALLR--RFDEIIF 317
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 219-376 1.42e-17

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 79.63  E-value: 1.42e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 219 LKRSVMGDLDRFIRRKDFYKRVGKPWKRGYLLYGPPGTGKTSLVAAIANYlkfdiYDLQLASVR-----------EDADL 287
Cdd:cd19511   1 VKRELKEAVEWPLKHPDAFKRLGIRPPKGVLLYGPPGCGKTLLAKALASE-----AGLNFISVKgpelfskyvgeSERAV 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 288 RRLLLGTTNS--SILLVEDIDCavdlhtrLQPK-TQDDTKGSSMLTLSGLLTCIDGLwsSCGDERIVIFTTTHKERLDPA 364
Cdd:cd19511  76 REIFQKARQAapCIIFFDEIDS-------LAPRrGQSDSSGVTDRVVSQLLTELDGI--ESLKGVVVIAATNRPDMIDPA 146

                       170
                ....*....|..
gi 15238021 365 LLRPGRMDMHIH 376
Cdd:cd19511 147 LLRPGRLDKLIY 158
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 209-376 8.38e-17

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 78.04  E-value: 8.38e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 209 TFDTMAMNEELKRSVMGDLDrFIRRKDFYKRVGKPWKRGYLLYGPPGTGKTSLVAAIANYLKFDIYDLQLASVRE----- 283
Cdd:cd19501   2 TFKDVAGCEEAKEELKEVVE-FLKNPEKFTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEmfvgv 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 284 DADLRRLLLGTTNS---SILLVEDIDcAVDLHtrlqpktqddtKGSSML--------TLSGLLTCIDGLWSSCGdeRIVI 352
Cdd:cd19501  81 GASRVRDLFEQAKKnapCIVFIDEID-AVGRK-----------RGAGLGgghdereqTLNQLLVEMDGFESNTG--VIVI 146

                       170       180
                ....*....|....*....|....
gi 15238021 353 FTTTHKERLDPALLRPGRMDMHIH 376
Cdd:cd19501 147 AATNRPDVLDPALLRPGRFDRQVY 170
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 231-375 2.86e-16

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 76.29  E-value: 2.86e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 231 IRRKDFYKRVGKPWKRGYLLYGPPGTGKTSLVAAIANYLKFDIYDLQLASV------REDADLRRLL--LGTTNSSILLV 302
Cdd:cd19518  20 ILPPEYFQHLGVEPPRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIvsgvsgESEEKIRELFdqAISNAPCIVFI 99

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15238021 303 EDIDCavdlhtrLQPKTQDDTKGSSMLTLSGLLTCIDGL--WSSCGDERIVIFTTTHKERLDPALLRPGRMDMHI 375
Cdd:cd19518 100 DEIDA-------ITPKRESAQREMERRIVSQLLTCMDELnnEKTAGGPVLVIGATNRPDSLDPALRRAGRFDREI 167
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
210-412 2.42e-15

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 75.31  E-value: 2.42e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 210 FDTMAMNEELKRSvMGDLDRFIRRKDFYKRVGKPWKRGYLLYGPPGTGKTSLVAAIANYLKFDIYDLQLAS-----VRED 284
Cdd:COG1223   1 LDDVVGQEEAKKK-LKLIIKELRRRENLRKFGLWPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSligsyLGET 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 285 A-DLRRLLLGT-TNSSILLVEDIDcAVDLHTRLQpktQDDTKGSSmlTLSGLLTCIDGLWSSCgderIVIFTTTHKERLD 362
Cdd:COG1223  80 ArNLRKLFDFArRAPCVIFFDEFD-AIAKDRGDQ---NDVGEVKR--VVNALLQELDGLPSGS----VVIAATNHPELLD 149

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15238021 363 PALLRpgRMDMHI-------------------HMGHCCFDVFKTLASNYLGLSHDDphhlypeIERLIK 412
Cdd:COG1223 150 SALWR--RFDEVIefplpdkeerkeilelnlkKFPLPFELDLKKLAKKLEGLSGAD-------IEKVLK 209
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 217-377 9.20e-15

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 71.76  E-value: 9.20e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 217 EELKRSVMGDLdrfiRRKDFYKRVGKPWKRGYLLYGPPGTGKTSLVAAIANYLKFDIYDL---QLAS--VREDADLRRLL 291
Cdd:cd19529   3 QELKEAVEWPL----LKPEVFKRLGIRPPKGILLYGPPGTGKTLLAKAVATESNANFISVkgpELLSkwVGESEKAIREI 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 292 LGTTNSS---ILLVEDIDCavdlhtrLQPKT-QDDTKGSSMLTLSGLLTCIDGLWSScgDERIVIFTTTHKERLDPALLR 367
Cdd:cd19529  79 FRKARQVapcVIFFDEIDS-------IAPRRgTTGDSGVTERVVNQLLTELDGLEEM--NGVVVIAATNRPDIIDPALLR 149

                       170
                ....*....|
gi 15238021 368 PGRMDMHIHM 377
Cdd:cd19529 150 AGRFDRLIYI 159
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 231-378 1.54e-14

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 71.31  E-value: 1.54e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 231 IRRKDFYKRVGKPWKRGYLLYGPPGTGKTSLVAAIANYLK---FDIYDLQLASV---REDADLRRLLL-GTTNS-SILLV 302
Cdd:cd19519  20 LRHPELFKAIGIKPPRGILLYGPPGTGKTLIARAVANETGaffFLINGPEIMSKlagESESNLRKAFEeAEKNApAIIFI 99

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15238021 303 EDIDCavdlhtrLQPKTQDDTKGSSMLTLSGLLTCIDGLWSScgDERIVIFTTTHKERLDPALLRPGRMDMHIHMG 378
Cdd:cd19519 100 DEIDA-------IAPKREKTHGEVERRIVSQLLTLMDGLKQR--AHVIVMAATNRPNSIDPALRRFGRFDREIDIG 166
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 235-376 3.72e-14

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 70.44  E-value: 3.72e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 235 DFYKRVGKPWKRGYLLYGPPGTGKTSLVAAIAN-----YLKFDIYDLQLASVREDADLRRLL--LGTTNS-SILLVEDID 306
Cdd:cd19502  27 ELFEELGIEPPKGVLLYGPPGTGKTLLAKAVANhtdatFIRVVGSELVQKYIGEGARLVRELfeMAREKApSIIFIDEID 106

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15238021 307 CavdLHTRlqpKTQDDTKGSSML--TLSGLLTCIDGlWSSCGDERiVIFTTTHKERLDPALLRPGRMDMHIH 376
Cdd:cd19502 107 A---IGAK---RFDSGTGGDREVqrTMLELLNQLDG-FDPRGNIK-VIMATNRPDILDPALLRPGRFDRKIE 170
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 217-372 5.88e-14

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 69.44  E-value: 5.88e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 217 EELKRSVMgdldRFIRRKDFYKRVGKPWKRGYLLYGPPGTGKTSLVAAIANYLKFDIYDLQLASV------REDADLRRL 290
Cdd:cd19530   6 EELTMSIL----RPIKRPDIYKALGIDLPTGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELlnkyvgESERAVRQV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 291 LLGTTNSS--ILLVEDIDCavdlhtrLQPKTQDDTKGSSMLTLSGLLTCIDGLWSScgDERIVIFTTTHKERLDPALLRP 368
Cdd:cd19530  82 FQRARASApcVIFFDEVDA-------LVPKRGDGGSWASERVVNQLLTEMDGLEER--SNVFVIAATNRPDIIDPAMLRP 152


                ....
gi 15238021 369 GRMD 372
Cdd:cd19530 153 GRLD 156
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 217-377 7.10e-14

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 69.08  E-value: 7.10e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 217 EELKRSVMGDLDRfirrKDFYKRVGKPWKRGYLLYGPPGTGKTSLVAAIANYLKFDIYDL---QLASV---REDADLRRL 290
Cdd:cd19528   3 RELQELVQYPVEH----PDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISVkgpELLTMwfgESEANVRDI 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 291 LLGTTNSS--ILLVEDIDCAvdlhTRLQPKTQDDTKGSSMLTLSGLLTCIDGLWSScgDERIVIFTTTHKERLDPALLRP 368
Cdd:cd19528  79 FDKARAAApcVLFFDELDSI----AKARGGNIGDAGGAADRVINQILTEMDGMNTK--KNVFIIGATNRPDIIDPAILRP 152


                ....*....
gi 15238021 369 GRMDMHIHM 377
Cdd:cd19528 153 GRLDQLIYI 161
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 209-378 5.18e-13

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 71.48  E-value: 5.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021   209 TFDTMAMNEELKRSVMGDLDRFIRRKDFYKRVGKPWKRGYLLYGPPGTGKTSLVAAIANYLKFDIYDLQLASV------R 282
Cdd:TIGR01243 176 TYEDIGGLKEAKEKIREMVELPMKHPELFEHLGIEPPKGVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEImskyygE 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021   283 EDADLRRLLLGTTNS--SILLVEDIDCavdlhtrLQPKTQDDTKGSSMLTLSGLLTCIDGLwsscgDER---IVIFTTTH 357
Cdd:TIGR01243 256 SEERLREIFKEAEENapSIIFIDEIDA-------IAPKREEVTGEVEKRVVAQLLTLMDGL-----KGRgrvIVIGATNR 323

                         170       180
                  ....*....|....*....|.
gi 15238021   358 KERLDPALLRPGRMDMHIHMG 378
Cdd:TIGR01243 324 PDALDPALRRPGRFDREIVIR 344
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 233-375 4.30e-12

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 67.87  E-value: 4.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021  233 RKDFYKRVG-KPWKrGYLLYGPPGTGKTSLVAAIAN-----YLKFDIYDLQLASVREDADLRRLL--LGTTNS-SILLVE 303
Cdd:PTZ00361 205 HPELYDDIGiKPPK-GVILYGPPGTGKTLLAKAVANetsatFLRVVGSELIQKYLGDGPKLVRELfrVAEENApSIVFID 283

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15238021  304 DIDCavdlhtrLQPKTQDDTKGSS---MLTLSGLLTCIDGlWSSCGDERiVIFTTTHKERLDPALLRPGRMDMHI 375
Cdd:PTZ00361 284 EIDA-------IGTKRYDATSGGEkeiQRTMLELLNQLDG-FDSRGDVK-VIMATNRIESLDPALIRPGRIDRKI 349
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 237-375 5.74e-12

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 63.60  E-value: 5.74e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 237 YKRVGKPWKRGYLLYGPPGTGKTSLVAAIANYlkfdiYDLQLASVREDADLR----------RLLLGTTNSS---ILLVE 303
Cdd:cd19526  19 FASSPLRLRSGILLYGPPGCGKTLLASAIASE-----CGLNFISVKGPELLNkyigaseqnvRDLFSRAQSAkpcILFFD 93

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15238021 304 DIDcavdlhtRLQPKTQDDTKGSSMLTLSGLLTCIDGLWSscGDERIVIFTTTHKERLDPALLRPGRMDMHI 375
Cdd:cd19526  94 EFD-------SIAPKRGHDSTGVTDRVVNQLLTQLDGVEG--LDGVYVLAATSRPDLIDPALLRPGRLDKLV 156
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
208-378 6.77e-12

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 67.75  E-value: 6.77e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021  208 STFDTMAMNEELKRSVmGDLDRFIRRKDFYKRVGKPWKRGYLLYGPPGTGKTSLVAAIANYLKFDIYDLQlasvreDADL 287
Cdd:PRK10733 149 TTFADVAGCDEAKEEV-AELVEYLREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTIS------GSDF 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021  288 RRLLLGTTNSS--------------ILLVEDIDcAVDLHTRLQPKTQDDTKGSsmlTLSGLLTCIDGLWsscGDERIVIF 353
Cdd:PRK10733 222 VEMFVGVGASRvrdmfeqakkaapcIIFIDEID-AVGRQRGAGLGGGHDEREQ---TLNQMLVEMDGFE---GNEGIIVI 294

                        170       180
                 ....*....|....*....|....*.
gi 15238021  354 TTTHK-ERLDPALLRPGRMDMHIHMG 378
Cdd:PRK10733 295 AATNRpDVLDPALLRPGRFDRQVVVG 320
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 245-378 9.02e-12

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 62.93  E-value: 9.02e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 245 KRGYLLYGPPGTGKTSLVAAIANYL---KFDIYDLQLASVREDADLRRLLLGTTNS-----------SILLVEDIDcavD 310
Cdd:cd00009  19 PKNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVAELFGHFLVRllfelaekakpGVLFIDEID---S 95

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15238021 311 LHTRLQPKTQDdtkgsSMLTLSGLLTCIdglwsscgDERIVIFTTTHKERLDPALLRPGRMDMHIHMG 378
Cdd:cd00009  96 LSRGAQNALLR-----VLETLNDLRIDR--------ENVRVIGATNRPLLGDLDRALYDRLDIRIVIP 150
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 219-372 1.08e-11

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 62.92  E-value: 1.08e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 219 LKRSVMGDLDRFIRRKD-FYKRVGKpwKRGYLLYGPPGTGKTSLVAAIANYlkfdiYDLQLASVR-----------EDAD 286
Cdd:cd19527   1 VKKEILDTIQLPLEHPElFSSGLRK--RSGILLYGPPGTGKTLLAKAIATE-----CSLNFLSVKgpelinmyigeSEAN 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 287 LRRLLLGTTNSS--ILLVEDIDcavdlhtRLQPK--TQDDTKGSSMLTLSGLLTCIDGLwSSCGDERIVIFTTTHKERLD 362
Cdd:cd19527  74 VREVFQKARDAKpcVIFFDELD-------SLAPSrgNSGDSGGVMDRVVSQLLAELDGM-SSSGQDVFVIGATNRPDLLD 145

                       170
                ....*....|
gi 15238021 363 PALLRPGRMD 372
Cdd:cd19527 146 PALLRPGRFD 155
ftsH CHL00176
cell division protein; Validated
 209-375 3.76e-11

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 65.46  E-value: 3.76e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021  209 TFDTMAMNEELKRSvMGDLDRFIRRKDFYKRVGKPWKRGYLLYGPPGTGKTSLVAAIANYLKFDIYDLQLASVRE----- 283
Cdd:CHL00176 181 TFRDIAGIEEAKEE-FEEVVSFLKKPERFTAVGAKIPKGVLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEmfvgv 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021  284 -DADLRRLLLGTTNSS--ILLVEDIDcAV------DLHTRLQPKTQddtkgssmlTLSGLLTCIDGLWSSCGdeRIVIFT 354
Cdd:CHL00176 260 gAARVRDLFKKAKENSpcIVFIDEID-AVgrqrgaGIGGGNDEREQ---------TLNQLLTEMDGFKGNKG--VIVIAA 327

                        170       180
                 ....*....|....*....|.
gi 15238021  355 TTHKERLDPALLRPGRMDMHI 375
Cdd:CHL00176 328 TNRVDILDAALLRPGRFDRQI 348
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 235-375 1.84e-10

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 62.47  E-value: 1.84e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021  235 DFYKRVGKPWKRGYLLYGPPGTGKTSLVAAIANYLKF-----------------------DIYDLqlasVREDAdlrrll 291
Cdd:PTZ00454 169 ELYEQIGIDPPRGVLLYGPPGTGKTMLAKAVAHHTTAtfirvvgsefvqkylgegprmvrDVFRL----ARENA------ 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021  292 lgttnSSILLVEDIDCAVDlhTRLQPKTQDDTKGSSMLTlsGLLTCIDGLWSSCGDEriVIFTTTHKERLDPALLRPGRM 371
Cdd:PTZ00454 239 -----PSIIFIDEVDSIAT--KRFDAQTGADREVQRILL--ELLNQMDGFDQTTNVK--VIMATNRADTLDPALLRPGRL 307


                 ....
gi 15238021  372 DMHI 375
Cdd:PTZ00454 308 DRKI 311
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 231-376 2.92e-10

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 58.90  E-value: 2.92e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 231 IRRKDFYKRVGKPWkRGYLLYGPPGTGKTSLVAAIANYLK---FDIYDLQLAS--VREDADLRRLLLGTTN---SSILLV 302
Cdd:cd19509  19 SLRPDLFPGLRGPP-RGILLYGPPGTGKTLLARAVASESGstfFSISASSLVSkwVGESEKIVRALFALARelqPSIIFI 97

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15238021 303 EDIDcavdlhTRLQPKTQDDTKGSSMLTlSGLLTCIDGLWSSCGDERIVIFTTTHKERLDPALLRpgRMDMHIH 376
Cdd:cd19509  98 DEID------SLLSERGSGEHEASRRVK-TEFLVQMDGVLNKPEDRVLVLGATNRPWELDEAFLR--RFEKRIY 162
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 217-386 2.99e-10

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 62.62  E-value: 2.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021   217 EELKRSVMGDLDRFIRRKDFYKRVGKPWKRGYLLYGPPGTGKTSLVAAIANYLKFDIYDLQLASV------REDADLRRL 290
Cdd:TIGR01243 459 EEVKQELREAVEWPLKHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEIlskwvgESEKAIREI 538

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021   291 LLGTTNSS--ILLVEDIDC-AVDLHTRLQPKTQDDtkgssmlTLSGLLTCIDGLWSSCGdeRIVIFTTTHKERLDPALLR 367
Cdd:TIGR01243 539 FRKARQAApaIIFFDEIDAiAPARGARFDTSVTDR-------IVNQLLTEMDGIQELSN--VVVIAATNRPDILDPALLR 609

                         170       180
                  ....*....|....*....|...
gi 15238021   368 PGRMDMHIHM----GHCCFDVFK 386
Cdd:TIGR01243 610 PGRFDRLILVpppdEEARKEIFK 632
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 246-376 1.32e-09

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 59.85  E-value: 1.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021  246 RGYLLYGPPGTGKTSLVAAIANYL--------------KF---------DIYDLqlasVREDAdlrrlllgttnSSILLV 302
Cdd:PRK03992 166 KGVLLYGPPGTGKTLLAKAVAHETnatfirvvgselvqKFigegarlvrELFEL----AREKA-----------PSIIFI 230

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15238021  303 EDIDcAVDLHtrlqpKTQDDTKGSSML--TLSGLLTCIDGlWSSCGDERIvIFTTTHKERLDPALLRPGRMDMHIH 376
Cdd:PRK03992 231 DEID-AIAAK-----RTDSGTSGDREVqrTLMQLLAEMDG-FDPRGNVKI-IAATNRIDILDPAILRPGRFDRIIE 298
PRK04195 PRK04195
replication factor C large subunit; Provisional
 207-300 1.65e-08

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 56.47  E-value: 1.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021  207 PSTFDTMAMNEELKRSVMGDLDRFIRrkdfykrvGKPwKRGYLLYGPPGTGKTSLVAAIANYLKFDIYDLQlAS-VREDA 285
Cdd:PRK04195  10 PKTLSDVVGNEKAKEQLREWIESWLK--------GKP-KKALLLYGPPGVGKTSLAHALANDYGWEVIELN-ASdQRTAD 79

                         90
                 ....*....|....*
gi 15238021  286 DLRRLLLGTTNSSIL 300
Cdd:PRK04195  80 VIERVAGEAATSGSL 94
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 246-372 2.27e-08

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 53.67  E-value: 2.27e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 246 RGYLLYGPPGTGKTSLVAAIANYLKFDIYDLQLAsVREDADL---------RRLLL-----GTTNSSILLVEDIDCAVDL 311
Cdd:cd19517  35 RGVLFHGPPGTGKTLMARALAAECSKGGQKVSFF-MRKGADClskwvgeaeRQLRLlfeeaYRMQPSIIFFDEIDGLAPV 113

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15238021 312 HTrlqpKTQDDTKGSsmlTLSGLLTCIDGLwsscgDER---IVIFTTTHKERLDPALLRPGRMD 372
Cdd:cd19517 114 RS----SKQEQIHAS---IVSTLLALMDGL-----DNRgqvVVIGATNRPDALDPALRRPGRFD 165
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 233-367 4.44e-08

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 52.54  E-value: 4.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 233 RKDFYKRVGKPwKRGYLLYGPPGTGKTSLVAAIANYLKFDIYDLQLAS-----VREDADLRRLLLGTTNS---SILLVED 304
Cdd:cd19524  22 RPELFTGLRAP-ARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASltskyVGEGEKLVRALFAVARElqpSIIFIDE 100

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15238021 305 IDcavdlhTRLQPKTQDDTKGSSMLTlSGLLTCIDGLWSScGDERIVIFTTTHK-ERLDPALLR 367
Cdd:cd19524 101 VD------SLLSERSEGEHEASRRLK-TEFLIEFDGVQSN-GDDRVLVMGATNRpQELDDAVLR 156
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 245-378 1.19e-07

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 50.83  E-value: 1.19e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021    245 KRGYLLYGPPGTGKTSLVAAIANYLKFDIYDLQL--ASVREDADLRRLLLGTTNSSILLVEDIDCAVDLHTRLQPKTQD- 321
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPGGGVIYidGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPDv 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15238021    322 ---------DTKGSSMLTLSGLLTCIDGLWSSCGDeRIVIFTTTHKERLDPALLRPgRMDMHIHMG 378
Cdd:smart00382  82 lildeitslLDAEQEALLLLLEELRLLLLLKSEKN-LTVILTTNDEKDLGPALLRR-RFDRRIVLL 145
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 235-377 3.41e-07

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 49.98  E-value: 3.41e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 235 DFYKRVGKPWKrGYLLYGPPGTGKTSLVAAIANYLKFDIYDLQLASVR-----EDADLRRLLLGTTN---SSILLVEDID 306
Cdd:cd19522  24 EFFKGIRRPWK-GVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTskyrgESEKLVRLLFEMARfyaPTTIFIDEID 102

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15238021 307 cavDLHTRlqpKTQDDTKGSSMLTLSGLLTCIDGLWSSCGDER-----IVIFTTTHKERLDPALLRpgRMDMHIHM 377
Cdd:cd19522 103 ---SICSR---RGTSEEHEASRRVKSELLVQMDGVGGASENDDpskmvMVLAATNFPWDIDEALRR--RLEKRIYI 170
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 217-371 1.24e-06

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 48.19  E-value: 1.24e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 217 EELKRSVMGDLdrfiRRKDFYKRvGKPWK--RGYLLYGPPGTGKTSLVAAIANYLKFDIYDLQLASVRED--------AD 286
Cdd:cd19520  10 TELKELVILPL----QRPELFDN-SRLLQppKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKwygesqklVA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 287 LRRLLLGTTNSSILLVEDIDcavdlhTRLQPKTQDDTKGSSMLTlSGLLTCIDGLWSSCGDERIVIFTTTHKERLDPALL 366
Cdd:cd19520  85 AVFSLASKLQPSIIFIDEID------SFLRQRSSTDHEATAMMK-AEFMSLWDGLSTDGNCRVIVMGATNRPQDLDEAIL 157


                ....*
gi 15238021 367 RpgRM 371
Cdd:cd19520 158 R--RM 160
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 249-305 4.97e-06

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 48.51  E-value: 4.97e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15238021 249 LLYGPPGTGKTSLVAAIANYLKFDIYDLQ--LASVredADLR------RLLLGTTNSSILLVEDI 305
Cdd:COG2256  53 ILWGPPGTGKTTLARLIANATDAEFVALSavTSGV---KDIRevieeaRERRAYGRRTILFVDEI 114
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 231-367 8.32e-06

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 46.52  E-value: 8.32e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 231 IRRKDFYKRVGKPWKrGYLLYGPPGTGKTSLVAAIANYLKFDIYDLQLAS-----VREDADLRRLLLGTTN---SSILLV 302
Cdd:cd19525  42 MLRPDIFTGLRGPPK-GILLFGPPGTGKTLIGKCIASQSGATFFSISASSltskwVGEGEKMVRALFSVARckqPAVIFI 120

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15238021 303 EDIDcavdlhtRLQPKTQDDTKGSSMLTLSGLLTCIDGLWSSCGDERIVIFTTTHKERLDPALLR 367
Cdd:cd19525 121 DEID-------SLLSQRGEGEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARR 178
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 249-322 1.16e-05

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 47.39  E-value: 1.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021  249 LLYGPPGTGKTSLVAAIANYLKFDIY----------DLQLASvrEDADLRRLLLGTTnssILLVEDIdcavdlHtRLQpK 318
Cdd:PRK13342  40 ILWGPPGTGKTTLARIIAGATDAPFEalsavtsgvkDLREVI--EEARQRRSAGRRT---ILFIDEI------H-RFN-K 106


                 ....
gi 15238021  319 TQDD 322
Cdd:PRK13342 107 AQQD 110
PRK08116 PRK08116
hypothetical protein; Validated
 242-269 1.29e-05

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 46.55  E-value: 1.29e-05
                         10        20        30
                 ....*....|....*....|....*....|.
gi 15238021  242 KPWKR---GYLLYGPPGTGKTSLVAAIANYL 269
Cdd:PRK08116 108 EEMKKenvGLLLWGSVGTGKTYLAACIANEL 138
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 231-367 1.73e-05

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 44.88  E-value: 1.73e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 231 IRRKDFYKRVGKPwKRGYLLYGPPGTGKTSLVAAIANYLKFDIYDLQLASVRED--ADLRRLLLGT------TNSSILLV 302
Cdd:cd19523  20 LLRPDAFSGLLRL-PRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKwaGEGEKILQASflaarcRQPSVLFI 98

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15238021 303 EDIDCAVdlhtrlqpKTQDDTKGSSMLTLSGLLTCIDGLWSSCGDERIVIFTTTHKERLDPALLR 367
Cdd:cd19523  99 SDLDALL--------SSQDDEASPVGRLQVELLAQLDGVLGSGEDGVLVVCTTSKPEEIDESLRR 155
RecA-like_Lon cd19500
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ...
 249-288 7.99e-05

lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410908 [Multi-domain]  Cd Length: 182  Bit Score: 43.32  E-value: 7.99e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 15238021 249 LLYGPPGTGKTSLVAAIANYLKFDIYDLQLASVREDADLR 288
Cdd:cd19500  41 CLVGPPGVGKTSLGKSIARALGRKFVRISLGGVRDEAEIR 80
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 242-266 1.07e-04

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 42.93  E-value: 1.07e-04
                        10        20
                ....*....|....*....|....*
gi 15238021 242 KPWkRGYLLYGPPGTGKTSLVAAIA 266
Cdd:cd19521  38 KPW-SGILLYGPPGTGKSYLAKAVA 61
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 217-372 2.60e-04

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 41.59  E-value: 2.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 217 EELKRSVMgdldrfIRRKDFYK---RVGKPWKRGYLLYGPPGTGKTSLVAAIANY-----LKFDIYDLQLASVRE-DADL 287
Cdd:cd19507   6 DNLKDWLK------KRKAAFSKqasAYGLPTPKGLLLVGIQGTGKSLTAKAIAGVwqlplLRLDMGRLFGGLVGEsESRL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 288 RRLL--LGTTNSSILLVEDIDCAVdlhTRLQPKTQddtKGSSMLTLSGLLTcidglWSScgdERI----VIFTTTHKERL 361
Cdd:cd19507  80 RQMIqtAEAIAPCVLWIDEIEKGF---SNADSKGD---SGTSSRVLGTFLT-----WLQ---EKKkpvfVVATANNVQSL 145

                       170
                ....*....|.
gi 15238021 362 DPALLRPGRMD 372
Cdd:cd19507 146 PPELLRKGRFD 156
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 229-269 3.71e-04

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 41.34  E-value: 3.71e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 15238021   229 RFIRR-------KDFYKRVGKPWKRGYLLYGPPGTGKTSLVAAIANYL 269
Cdd:pfam13191   1 RLVGReeeleqlLDALDRVRSGRPPSVLLTGEAGTGKTTLLRELLRAL 48
RecA-like_Ycf2 cd19505
ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; ...
 234-375 7.12e-04

ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; however, its function remains unclear. The gene encoding YCF2 is the largest known plastid gene in angiosperms and has been used to predict phylogenetic relationships. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410913 [Multi-domain]  Cd Length: 161  Bit Score: 40.05  E-value: 7.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 234 KDFYKRVGKPWKRGYLLYGPPGTGKTSLVAAIA-----------------NYLKFDIYDLQLASVREDADLRRL-----L 291
Cdd:cd19505   1 KPFSLRLGLSPSKGILLIGSIETGRSYLIKSLAansyvplirislnkllyNKPDFGNDDWIDGMLILKESLHRLnlqfeL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 292 LGTTNSSILLVEDIDcavDLHTRlqpKTQDDTKGSSMLTLSGLLTCIDGLWSSCGDERIVIFTTTH-KERLDPALLRPGR 370
Cdd:cd19505  81 AKAMSPCIIWIPNIH---ELNVN---RSTQNLEEDPKLLLGLLLNYLSRDFEKSSTRNILVIASTHiPQKVDPALIAPNR 154


                ....*
gi 15238021 371 MDMHI 375
Cdd:cd19505 155 LDTCI 159
DEXXQc_Helz-like cd18038
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and ...
 248-266 8.85e-04

DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and similar proteins. Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. All are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350796 [Multi-domain]  Cd Length: 229  Bit Score: 40.68  E-value: 8.85e-04
                        10        20
                ....*....|....*....|
gi 15238021 248 YLLYGPPGTGKTS-LVAAIA 266
Cdd:cd18038  23 YIIFGPPGTGKTVtLVEAIL 42
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
242-269 9.68e-04

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 41.11  E-value: 9.68e-04
                        10        20
                ....*....|....*....|....*...
gi 15238021 242 KPWKRGYLLYGPPGTGKTSLVAAIANYL 269
Cdd:COG0470  15 GRLPHALLLHGPPGIGKTTLALALARDL 42
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
239-273 1.21e-03

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 41.11  E-value: 1.21e-03
                        10        20        30
                ....*....|....*....|....*....|....*
gi 15238021 239 RVGKPWKRGYLLYGPPGTGKTSLVAAIANYLKFDI 273
Cdd:COG1224  58 KEGKMAGKGILIVGPPGTGKTALAVAIARELGEDT 92
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
 244-269 1.25e-03

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 40.12  E-value: 1.25e-03
                        10        20
                ....*....|....*....|....*.
gi 15238021 244 WKRGYLLYGPPGTGKTSLVAAIANYL 269
Cdd:cd19508  51 WNRLVLLHGPPGTGKTSLCKALAQKL 76
ruvB TIGR00635
Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions ...
 249-305 1.40e-03

Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions are known are 5'-3' DNA helicases that, as part of a complex with RuvA homologs serve as a 5'-3' Holliday junction helicase. RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129721 [Multi-domain]  Cd Length: 305  Bit Score: 40.75  E-value: 1.40e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 15238021   249 LLYGPPGTGKTSLVAAIANYLKFDIYDLQLASVREDADLRRLLLGTTNSSILLVEDI 305
Cdd:TIGR00635  34 LLYGPPGLGKTTLAHIIANEMGVNLKITSGPALEKPGDLAAILTNLEEGDVLFIDEI 90
PRK13341 PRK13341
AAA family ATPase;
249-268 1.48e-03

AAA family ATPase;


Pssm-ID: 237354 [Multi-domain]  Cd Length: 725  Bit Score: 41.19  E-value: 1.48e-03
                         10        20
                 ....*....|....*....|
gi 15238021  249 LLYGPPGTGKTSLVAAIANY 268
Cdd:PRK13341  56 ILYGPPGVGKTTLARIIANH 75
DEXXQc_Upf1-like cd17934
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, ...
 249-299 1.49e-03

DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), coronavirus Nsp13, and similar proteins. They belong to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438708 [Multi-domain]  Cd Length: 121  Bit Score: 38.37  E-value: 1.49e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 15238021 249 LLYGPPGTGKTSLVAAIANYLkfdiydlqlasVREDADLRRLLLGTTNSSI 299
Cdd:cd17934   3 LIQGPPGTGKTTTIAAIVLQL-----------LKGLRGKRVLVTAQSNVAV 42
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
246-378 1.67e-03

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 40.79  E-value: 1.67e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 246 RGYLLYGPPGTGKTSLVAAIANYLK---FDIydlqlaS---------------VRedaDL----RRlllgttNS-SILLV 302
Cdd:COG0465 176 KGVLLVGPPGTGKTLLAKAVAGEAGvpfFSI------SgsdfvemfvgvgasrVR---DLfeqaKK------NApCIIFI 240

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 303 EDIDcAVDLHtRlqpktqddtkGSSML--------TLSGLLTCIDGLwsscgDER---IVIFTTTHKERLDPALLRPGRM 371
Cdd:COG0465 241 DEID-AVGRQ-R----------GAGLGgghdereqTLNQLLVEMDGF-----EGNegvIVIAATNRPDVLDPALLRPGRF 303


                ....*..
gi 15238021 372 DMHIHMG 378
Cdd:COG0465 304 DRQVVVD 310
PRK08939 PRK08939
primosomal protein DnaI; Reviewed
 161-270 1.76e-03

primosomal protein DnaI; Reviewed


Pssm-ID: 236353 [Multi-domain]  Cd Length: 306  Bit Score: 40.24  E-value: 1.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021  161 HTELVLNSY---IPYVESKAKVINNERKILKMysyccmylKWQSVNLE---HPSTFDTMAMNEELKRSVMGDLDRFIRRk 234
Cdd:PRK08939  79 QPKLVMNGGyidVSYLPTPEKIEADEEKAIKK--------RIQSIYMPkdlLQASLADIDLDDRDRLDALMAALDFLEA- 149

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 15238021  235 dfYKRvgKPWKRGYLLYGPPGTGKTSLVAAIANYLK 270
Cdd:PRK08939 150 --YPP--GEKVKGLYLYGDFGVGKSYLLAAIANELA 181
DEXXQc_Mov10L1 cd18078
DEXXQ-box helicase domain of Mov10L1; Moloney leukemia virus 10-like protein 1 (Mov10L1) binds ...
 215-356 2.55e-03

DEXXQ-box helicase domain of Mov10L1; Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. Mov10L1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350836 [Multi-domain]  Cd Length: 230  Bit Score: 39.27  E-value: 2.55e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 215 MNEELKRSVmgdldrfirrKDFYKRVGKPWKrgYLLYGPPGTGKT-SLVAAIanylkfdiydLQLasVREDADLRRLLLG 293
Cdd:cd18078   2 LNELQKEAV----------KRILGGECRPLP--YILFGPPGTGKTvTIIEAI----------LQV--VYNLPRSRILVCA 57

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15238021 294 TTNSSILLVedidcAVDLHTRLQPKTQDDTKGSSMLTLSGllTCIDGLWSSCGDE---------RIVIFTTT 356
Cdd:cd18078  58 PSNSAADLV-----TSRLHESKVLKPGDMVRLNAVNRFES--TVIDARKLYCRLGedlskasrhRIVISTCS 122
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 249-379 2.92e-03

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 39.38  E-value: 2.92e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 249 LLYGPPGTGKTSLVAAIANYLkfdiydlqlasvreDADLRRL----------LLGTTN----------------SSILLV 302
Cdd:COG0714  35 LLEGVPGVGKTTLAKALARAL--------------GLPFIRIqftpdllpsdILGTYIydqqtgefefrpgplfANVLLA 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021 303 EDIDcavdlhtRLQPKTQddtkgssmltlSGLLTCIdglwsscgDER-IVIFTTTHKE-------------------RLD 362
Cdd:COG0714 101 DEIN-------RAPPKTQ-----------SALLEAM--------EERqVTIPGGTYKLpepflviatqnpieqegtyPLP 154

                       170
                ....*....|....*..
gi 15238021 363 PALLRpgRMDMHIHMGH 379
Cdd:COG0714 155 EAQLD--RFLLKLYIGY 169
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
249-273 2.97e-03

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 39.73  E-value: 2.97e-03
                         10        20
                 ....*....|....*....|....*
gi 15238021  249 LLYGPPGTGKTSLVAAIANYLKFDI 273
Cdd:PRK00080  55 LLYGPPGLGKTTLANIIANEMGVNI 79
VI_IcmF TIGR03348
type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to ...
 218-263 3.02e-03

type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to be associated with type VI secretion systems. [Cellular processes, Pathogenesis]


Pssm-ID: 274531 [Multi-domain]  Cd Length: 1169  Bit Score: 40.40  E-value: 3.02e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 15238021    218 ELKRSvmgdldRFIRRKDFYKrvgKPWkrgYLLYGPPGTGKTSLVA 263
Cdd:TIGR03348   96 LLKRS------RLGGRRYLYD---LPW---YLVIGPPGSGKTTLLQ 129
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
 249-273 3.59e-03

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 38.25  E-value: 3.59e-03
                          10        20
                  ....*....|....*....|....*
gi 15238021   249 LLYGPPGTGKTSLVAAIANYLKFDI 273
Cdd:pfam05496  37 LLYGPPGLGKTTLANIIANEMGVNI 61
ycf46 CHL00195
Ycf46; Provisional
 232-372 4.50e-03

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 39.23  E-value: 4.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021  232 RRKDFYKRV---GKPWKRGYLLYGPPGTGKtSLVA-AIAN-----YLKFDIYDLQLASVREDADLRRLLLGTTNSS---I 299
Cdd:CHL00195 243 RSTSFSKQAsnyGLPTPRGLLLVGIQGTGK-SLTAkAIANdwqlpLLRLDVGKLFGGIVGESESRMRQMIRIAEALspcI 321

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15238021  300 LLVEDIDCAVdlhtrlqpkTQDDTKGSSMLTLSGLLTCIDglWSScgdER----IVIFTTTHKERLDPALLRPGRMD 372
Cdd:CHL00195 322 LWIDEIDKAF---------SNSESKGDSGTTNRVLATFIT--WLS---EKkspvFVVATANNIDLLPLEILRKGRFD 384
clpC CHL00095
Clp protease ATP binding subunit
 160-269 6.26e-03

Clp protease ATP binding subunit


Pssm-ID: 214361 [Multi-domain]  Cd Length: 821  Bit Score: 39.27  E-value: 6.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238021  160 KHTELVLNSYIPYVESK--AKVINNERKILkmysyccmylkwqsVNLEHPSTFDT-MAMNEELKRSVMGD------LDRF 230
Cdd:CHL00095 459 KKTEEEKRLEVPVVTEEdiAEIVSAWTGIP--------------VNKLTKSESEKlLHMEETLHKRIIGQdeavvaVSKA 524

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 15238021  231 IRRKdfykRVG-KPWKR---GYLLYGPPGTGKTSLVAAIANYL 269
Cdd:CHL00095 525 IRRA----RVGlKNPNRpiaSFLFSGPTGVGKTELTKALASYF 563
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
 249-269 6.33e-03

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 38.98  E-value: 6.33e-03
                        10        20
                ....*....|....*....|.
gi 15238021 249 LLYGPPGTGKTSLVAAIANYL 269
Cdd:COG1401 225 ILAGPPGTGKTYLARRLAEAL 245
DnaA COG0593
Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];
249-306 6.41e-03

Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];


Pssm-ID: 440358 [Multi-domain]  Cd Length: 303  Bit Score: 38.63  E-value: 6.41e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15238021 249 LLYGPPGTGKTSLVAAIANYLKFDIYDLQ-------------LASVREDA--DLRRLLLgttNSSILLVEDID 306
Cdd:COG0593  38 FLYGGVGLGKTHLLHAIGNEALENNPGARvvyltaeeftndfINAIRNNTieEFKEKYR---SVDVLLIDDIQ 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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