NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|30693073|ref|NP_198553|]
View 

PRP38 family protein [Arabidopsis thaliana]

Protein Classification

PRP38 family protein( domain architecture ID 10505908)

pre-mRNA-splicing factor 38 (PRP38) family protein is involved in pre-mRNA splicing as a component of the spliceosome

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRP38 pfam03371
PRP38 family; Members of this family are related to the pre mRNA splicing factor PRP38 from ...
 4-157 1.13e-64

PRP38 family; Members of this family are related to the pre mRNA splicing factor PRP38 from yeast. Therefore all the members of this family could be involved in splicing. This conserved region could be involved in RNA binding. The putative domain is about 180 amino acids in length. PRP38 is a unique component of the U4/U6.U5 tri-small nuclear ribonucleoprotein (snRNP) particle and is necessary for an essential step late in spliceosome maturation.


:

Pssm-ID: 460901  Cd Length: 165  Bit Score: 203.44  E-value: 1.13e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693073     4 IQSNGRAYESLLEKVLSMNILSSDYFKE-LYGLKTyHEVIDEIYNQVNHVEPWMGGNCRGPSTAYCLLYKFFTMKLTVKQ 82
Cdd:pfam03371   1 KQINGNNPTLLIEKILRTRILDSLYWKEnLFGLNA-AELVDEIVEDVKYIGGWTYGGNRKPSPFLCLLLKLLQLQPTKEQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693073    83 MHGLLKHTDSPYIRAVGFLYLRYVADAKTLWTWYEPYIKDDEEFSP---GSNGRMTTMGVY--------YYFDTLFPRIP 151
Cdd:pfam03371  80 ILEYLNNEDFKYLRALGALYLRLTYPPKDVYKWLEPYLNDYRKLRIrllDGDYKLTHMDEFvddlltkdRVCGTILPRLP 159


                  ....*.
gi 30693073   152 VPVMRQ 157
Cdd:pfam03371 160 KRIVLE 165
PRP38_assoc pfam12871
Pre-mRNA-splicing factor 38-associated hydrophilic C-term; This domain is a hydrophilic region ...
 170-252 2.75e-10

Pre-mRNA-splicing factor 38-associated hydrophilic C-term; This domain is a hydrophilic region found at the C-terminus of plant and metazoan pre-mRNA-splicing factor 38 proteins. The function is not known.


:

Pssm-ID: 463734 [Multi-domain]  Cd Length: 98  Bit Score: 56.71  E-value: 2.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693073   170 KPSGSTGDMTRG-----SEDTARRPPSVKASLSVSFGQRAPHRASTRGSSPVRRPPPTGYDRNGGDevqqRSPRRSQSRD 244
Cdd:pfam12871   2 RVSVLEDDLDEEeeedeEEDEEASDESERASLSRKRRSRSRRRSSTRDRSRSRSRSRSRDRRSRGT----RDRRRDRDRD 77


                  ....*....
gi 30693073   245 YY-SDRDSD 252
Cdd:pfam12871  78 RYrSLRSRS 86
 
Name Accession Description Interval E-value
PRP38 pfam03371
PRP38 family; Members of this family are related to the pre mRNA splicing factor PRP38 from ...
 4-157 1.13e-64

PRP38 family; Members of this family are related to the pre mRNA splicing factor PRP38 from yeast. Therefore all the members of this family could be involved in splicing. This conserved region could be involved in RNA binding. The putative domain is about 180 amino acids in length. PRP38 is a unique component of the U4/U6.U5 tri-small nuclear ribonucleoprotein (snRNP) particle and is necessary for an essential step late in spliceosome maturation.


Pssm-ID: 460901  Cd Length: 165  Bit Score: 203.44  E-value: 1.13e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693073     4 IQSNGRAYESLLEKVLSMNILSSDYFKE-LYGLKTyHEVIDEIYNQVNHVEPWMGGNCRGPSTAYCLLYKFFTMKLTVKQ 82
Cdd:pfam03371   1 KQINGNNPTLLIEKILRTRILDSLYWKEnLFGLNA-AELVDEIVEDVKYIGGWTYGGNRKPSPFLCLLLKLLQLQPTKEQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693073    83 MHGLLKHTDSPYIRAVGFLYLRYVADAKTLWTWYEPYIKDDEEFSP---GSNGRMTTMGVY--------YYFDTLFPRIP 151
Cdd:pfam03371  80 ILEYLNNEDFKYLRALGALYLRLTYPPKDVYKWLEPYLNDYRKLRIrllDGDYKLTHMDEFvddlltkdRVCGTILPRLP 159


                  ....*.
gi 30693073   152 VPVMRQ 157
Cdd:pfam03371 160 KRIVLE 165
PRP38_assoc pfam12871
Pre-mRNA-splicing factor 38-associated hydrophilic C-term; This domain is a hydrophilic region ...
 170-252 2.75e-10

Pre-mRNA-splicing factor 38-associated hydrophilic C-term; This domain is a hydrophilic region found at the C-terminus of plant and metazoan pre-mRNA-splicing factor 38 proteins. The function is not known.


Pssm-ID: 463734 [Multi-domain]  Cd Length: 98  Bit Score: 56.71  E-value: 2.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693073   170 KPSGSTGDMTRG-----SEDTARRPPSVKASLSVSFGQRAPHRASTRGSSPVRRPPPTGYDRNGGDevqqRSPRRSQSRD 244
Cdd:pfam12871   2 RVSVLEDDLDEEeeedeEEDEEASDESERASLSRKRRSRSRRRSSTRDRSRSRSRSRSRDRRSRGT----RDRRRDRDRD 77


                  ....*....
gi 30693073   245 YY-SDRDSD 252
Cdd:pfam12871  78 RYrSLRSRS 86
 
Name Accession Description Interval E-value
PRP38 pfam03371
PRP38 family; Members of this family are related to the pre mRNA splicing factor PRP38 from ...
 4-157 1.13e-64

PRP38 family; Members of this family are related to the pre mRNA splicing factor PRP38 from yeast. Therefore all the members of this family could be involved in splicing. This conserved region could be involved in RNA binding. The putative domain is about 180 amino acids in length. PRP38 is a unique component of the U4/U6.U5 tri-small nuclear ribonucleoprotein (snRNP) particle and is necessary for an essential step late in spliceosome maturation.


Pssm-ID: 460901  Cd Length: 165  Bit Score: 203.44  E-value: 1.13e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693073     4 IQSNGRAYESLLEKVLSMNILSSDYFKE-LYGLKTyHEVIDEIYNQVNHVEPWMGGNCRGPSTAYCLLYKFFTMKLTVKQ 82
Cdd:pfam03371   1 KQINGNNPTLLIEKILRTRILDSLYWKEnLFGLNA-AELVDEIVEDVKYIGGWTYGGNRKPSPFLCLLLKLLQLQPTKEQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693073    83 MHGLLKHTDSPYIRAVGFLYLRYVADAKTLWTWYEPYIKDDEEFSP---GSNGRMTTMGVY--------YYFDTLFPRIP 151
Cdd:pfam03371  80 ILEYLNNEDFKYLRALGALYLRLTYPPKDVYKWLEPYLNDYRKLRIrllDGDYKLTHMDEFvddlltkdRVCGTILPRLP 159


                  ....*.
gi 30693073   152 VPVMRQ 157
Cdd:pfam03371 160 KRIVLE 165
PRP38_assoc pfam12871
Pre-mRNA-splicing factor 38-associated hydrophilic C-term; This domain is a hydrophilic region ...
 170-252 2.75e-10

Pre-mRNA-splicing factor 38-associated hydrophilic C-term; This domain is a hydrophilic region found at the C-terminus of plant and metazoan pre-mRNA-splicing factor 38 proteins. The function is not known.


Pssm-ID: 463734 [Multi-domain]  Cd Length: 98  Bit Score: 56.71  E-value: 2.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30693073   170 KPSGSTGDMTRG-----SEDTARRPPSVKASLSVSFGQRAPHRASTRGSSPVRRPPPTGYDRNGGDevqqRSPRRSQSRD 244
Cdd:pfam12871   2 RVSVLEDDLDEEeeedeEEDEEASDESERASLSRKRRSRSRRRSSTRDRSRSRSRSRSRDRRSRGT----RDRRRDRDRD 77


                  ....*....
gi 30693073   245 YY-SDRDSD 252
Cdd:pfam12871  78 RYrSLRSRS 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH