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Conserved domains on  [gi|15608440|ref|NP_215816|]
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release factor glutamine methyltransferase [Mycobacterium tuberculosis H37Rv]

Protein Classification

N5-glutamine methyltransferase family protein( domain architecture ID 11458394)

N5-glutamine methyltransferase family protein such as peptide chain release factor N(5)-glutamine methyltransferase, which modifies the glutamine residue in the universally conserved glycylglycylglutamine (GGQ) motif of peptide chain release factor, resulting in almost complete loss of release activity

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:0003676|GO:0032259|GO:1904047
PubMed:  12826405|12504684|12741815
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 22-301 1.71e-91

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 273.95  E-value: 1.71e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440  22 MTLRQAIDLAAALLAEAGVDSARCDAEQLAAHLAGTDRGRLPLF--EPPGDEFFGRYRDIVTARARRVPLQHLIGTVSFG 99
Cdd:COG2890   1 MTIRELLRWAAARLAAAGVDSARLEAELLLAHVLGLDRADLLLHpdRPLTEEELARLEALVARRAAGEPLAYILGEAEFY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440 100 PVVLHVGPGVFVPRPETEAILAWATAQ-SLPARPLIVDACTGSGALAVALAQHRANlglkARIIGIDDSDCALDYARRNA 178
Cdd:COG2890  81 GLEFKVDPGVLIPRPETEELVELALALlPAGAPPRVLDLGTGSGAIALALAKERPD----ARVTAVDISPDALAVARRNA 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440 179 A----GTPVELVRADVTTPrlLPElDGQVDLMVSNPPYIP--DAAVLEPEVAQHDPHHALFGGPDGMTVISAVVGLAGRW 252
Cdd:COG2890 157 ErlglEDRVRFLQGDLFEP--LPG-DGRFDLIVSNPPYIPedEIALLPPEVRDHEPRLALDGGEDGLDFYRRIIAQAPRL 233

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 15608440 253 LRPGGLFAVEHDDTTSSSTVDLVSSTKlFVDVQARKDLAGRPRFVTAMR 301
Cdd:COG2890 234 LKPGGWLLLEIGEDQGEAVRALLEAAG-FADVETHKDLAGRDRVVVARR 281
 
Name Accession Description Interval E-value
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 22-301 1.71e-91

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 273.95  E-value: 1.71e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440  22 MTLRQAIDLAAALLAEAGVDSARCDAEQLAAHLAGTDRGRLPLF--EPPGDEFFGRYRDIVTARARRVPLQHLIGTVSFG 99
Cdd:COG2890   1 MTIRELLRWAAARLAAAGVDSARLEAELLLAHVLGLDRADLLLHpdRPLTEEELARLEALVARRAAGEPLAYILGEAEFY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440 100 PVVLHVGPGVFVPRPETEAILAWATAQ-SLPARPLIVDACTGSGALAVALAQHRANlglkARIIGIDDSDCALDYARRNA 178
Cdd:COG2890  81 GLEFKVDPGVLIPRPETEELVELALALlPAGAPPRVLDLGTGSGAIALALAKERPD----ARVTAVDISPDALAVARRNA 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440 179 A----GTPVELVRADVTTPrlLPElDGQVDLMVSNPPYIP--DAAVLEPEVAQHDPHHALFGGPDGMTVISAVVGLAGRW 252
Cdd:COG2890 157 ErlglEDRVRFLQGDLFEP--LPG-DGRFDLIVSNPPYIPedEIALLPPEVRDHEPRLALDGGEDGLDFYRRIIAQAPRL 233

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 15608440 253 LRPGGLFAVEHDDTTSSSTVDLVSSTKlFVDVQARKDLAGRPRFVTAMR 301
Cdd:COG2890 234 LKPGGWLLLEIGEDQGEAVRALLEAAG-FADVETHKDLAGRDRVVVARR 281
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 22-299 1.87e-88

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 265.87  E-value: 1.87e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440   22 MTLRQAIDLAAALLAeagvdSARCDAEQLAAHLAGTDRGRLPLF--EPPGDEFFGRYRDIVTARARRVPLQHLIGTVSFG 99
Cdd:PRK09328   2 MTIAEALREATARLA-----SPRLDAELLLAHVLGLSRTDLLLNpeEELTPEELERFRALVARRAAGEPLQYILGEAEFW 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440  100 PVVLHVGPGVFVPRPETEAILAWA-TAQSLPARPLIVDACTGSGALAVALAQHRANlglkARIIGIDDSDCALDYARRNA 178
Cdd:PRK09328  77 GLDFKVSPGVLIPRPETEELVEWAlEALLLKEPLRVLDLGTGSGAIALALAKERPD----AEVTAVDISPEALAVARRNA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440  179 A---GTPVELVRADVttprLLPELDGQVDLMVSNPPYIP--DAAVLEPEVAQHDPHHALFGGPDGMTVISAVVGLAGRWL 253
Cdd:PRK09328 153 KhglGARVEFLQGDW----FEPLPGGRFDLIVSNPPYIPeaDIHLLQPEVRDHEPHLALFGGEDGLDFYRRIIEQAPRYL 228

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 15608440  254 RPGGLFAVEHDDTTSSSTVDLVSSTKlFVDVQARKDLAGRPRFVTA 299
Cdd:PRK09328 229 KPGGWLLLEIGYDQGEAVRALLAAAG-FADVETRKDLAGRDRVVLG 273
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 46-298 4.63e-79

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 241.22  E-value: 4.63e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440    46 DAEQLAAHLAGTDRGRLPLF--EPPGDEFFGRYRDIVTARARRVPLQHLIGTVSFGPVVLHVGPGVFVPRPETEAILAWA 123
Cdd:TIGR03534   1 DAELLLAHVLGKDRAQLLLHpeDELTPEELAAFDALLARRAAGEPVAYILGEREFYGLDFKVSPGVLIPRPETEELVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440   124 TAQsLPARPLIVDACTGSGALAVALAQHRANlglkARIIGIDDSDCALDYARRNAAG---TPVELVRADVTTPrlLPelD 200
Cdd:TIGR03534  81 LER-LKKGPRVLDLGTGSGAIALALAKERPD----ARVTAVDISPEALAVARKNARRlglENVEFLQGDWFEP--LP--S 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440   201 GQVDLMVSNPPYIP--DAAVLEPEVAQHDPHHALFGGPDGMTVISAVVGLAGRWLRPGGLFAVEHDDTTSSSTVDLVSST 278
Cdd:TIGR03534 152 GKFDLIVSNPPYIPeaDIHLLDPEVRDFEPRLALFGGEDGLDFYRRIIAQAPRLLKPGGWLLLEIGYDQGEAVRALFEAA 231

                         250       260
                  ....*....|....*....|
gi 15608440   279 KlFVDVQARKDLAGRPRFVT 298
Cdd:TIGR03534 232 G-FADVETRKDLAGKDRVVL 250
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 134-257 3.96e-11

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 58.73  E-value: 3.96e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440   134 IVDACTGSGALAVALAQHranlgLKARIIGIDDSDCALDYARRNAA--GTPVELVRADVTTprlLPELDGQVDLMVSNpp 211
Cdd:pfam13649   1 VLDLGCGTGRLTLALARR-----GGARVTGVDLSPEMLERARERAAeaGLNVEFVQGDAED---LPFPDGSFDLVVSS-- 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 15608440   212 yipdaAVLepevaqhdpHHalFGGPDGMTVISAVVglagRWLRPGG 257
Cdd:pfam13649  71 -----GVL---------HH--LPDPDLEAALREIA----RVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 134-262 6.47e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 50.12  E-value: 6.47e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440 134 IVDACTGSGALAVALAQHranlgLKARIIGIDDSDCALDYARRNAA---GTPVELVRADVTTprLLPELDGQVDLMVSNP 210
Cdd:cd02440   2 VLDLGCGTGALALALASG-----PGARVTGVDISPVALELARKAAAallADNVEVLKGDAEE--LPPEADESFDVIISDP 74

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 15608440 211 PYIPdaavlepevaqhdphhalfggpdGMTVISAVVGLAGRWLRPGGLFAVE 262
Cdd:cd02440  75 PLHH-----------------------LVEDLARFLEEARRLLKPGGVLVLT 103
 
Name Accession Description Interval E-value
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 22-301 1.71e-91

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 273.95  E-value: 1.71e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440  22 MTLRQAIDLAAALLAEAGVDSARCDAEQLAAHLAGTDRGRLPLF--EPPGDEFFGRYRDIVTARARRVPLQHLIGTVSFG 99
Cdd:COG2890   1 MTIRELLRWAAARLAAAGVDSARLEAELLLAHVLGLDRADLLLHpdRPLTEEELARLEALVARRAAGEPLAYILGEAEFY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440 100 PVVLHVGPGVFVPRPETEAILAWATAQ-SLPARPLIVDACTGSGALAVALAQHRANlglkARIIGIDDSDCALDYARRNA 178
Cdd:COG2890  81 GLEFKVDPGVLIPRPETEELVELALALlPAGAPPRVLDLGTGSGAIALALAKERPD----ARVTAVDISPDALAVARRNA 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440 179 A----GTPVELVRADVTTPrlLPElDGQVDLMVSNPPYIP--DAAVLEPEVAQHDPHHALFGGPDGMTVISAVVGLAGRW 252
Cdd:COG2890 157 ErlglEDRVRFLQGDLFEP--LPG-DGRFDLIVSNPPYIPedEIALLPPEVRDHEPRLALDGGEDGLDFYRRIIAQAPRL 233

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 15608440 253 LRPGGLFAVEHDDTTSSSTVDLVSSTKlFVDVQARKDLAGRPRFVTAMR 301
Cdd:COG2890 234 LKPGGWLLLEIGEDQGEAVRALLEAAG-FADVETHKDLAGRDRVVVARR 281
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 22-299 1.87e-88

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 265.87  E-value: 1.87e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440   22 MTLRQAIDLAAALLAeagvdSARCDAEQLAAHLAGTDRGRLPLF--EPPGDEFFGRYRDIVTARARRVPLQHLIGTVSFG 99
Cdd:PRK09328   2 MTIAEALREATARLA-----SPRLDAELLLAHVLGLSRTDLLLNpeEELTPEELERFRALVARRAAGEPLQYILGEAEFW 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440  100 PVVLHVGPGVFVPRPETEAILAWA-TAQSLPARPLIVDACTGSGALAVALAQHRANlglkARIIGIDDSDCALDYARRNA 178
Cdd:PRK09328  77 GLDFKVSPGVLIPRPETEELVEWAlEALLLKEPLRVLDLGTGSGAIALALAKERPD----AEVTAVDISPEALAVARRNA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440  179 A---GTPVELVRADVttprLLPELDGQVDLMVSNPPYIP--DAAVLEPEVAQHDPHHALFGGPDGMTVISAVVGLAGRWL 253
Cdd:PRK09328 153 KhglGARVEFLQGDW----FEPLPGGRFDLIVSNPPYIPeaDIHLLQPEVRDHEPHLALFGGEDGLDFYRRIIEQAPRYL 228

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 15608440  254 RPGGLFAVEHDDTTSSSTVDLVSSTKlFVDVQARKDLAGRPRFVTA 299
Cdd:PRK09328 229 KPGGWLLLEIGYDQGEAVRALLAAAG-FADVETRKDLAGRDRVVLG 273
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 46-298 4.63e-79

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 241.22  E-value: 4.63e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440    46 DAEQLAAHLAGTDRGRLPLF--EPPGDEFFGRYRDIVTARARRVPLQHLIGTVSFGPVVLHVGPGVFVPRPETEAILAWA 123
Cdd:TIGR03534   1 DAELLLAHVLGKDRAQLLLHpeDELTPEELAAFDALLARRAAGEPVAYILGEREFYGLDFKVSPGVLIPRPETEELVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440   124 TAQsLPARPLIVDACTGSGALAVALAQHRANlglkARIIGIDDSDCALDYARRNAAG---TPVELVRADVTTPrlLPelD 200
Cdd:TIGR03534  81 LER-LKKGPRVLDLGTGSGAIALALAKERPD----ARVTAVDISPEALAVARKNARRlglENVEFLQGDWFEP--LP--S 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440   201 GQVDLMVSNPPYIP--DAAVLEPEVAQHDPHHALFGGPDGMTVISAVVGLAGRWLRPGGLFAVEHDDTTSSSTVDLVSST 278
Cdd:TIGR03534 152 GKFDLIVSNPPYIPeaDIHLLDPEVRDFEPRLALFGGEDGLDFYRRIIAQAPRLLKPGGWLLLEIGYDQGEAVRALFEAA 231

                         250       260
                  ....*....|....*....|
gi 15608440   279 KlFVDVQARKDLAGRPRFVT 298
Cdd:TIGR03534 232 G-FADVETRKDLAGKDRVVL 250
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 41-301 1.13e-45

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 156.36  E-value: 1.13e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440    41 DSARCDAEQLAAHLAGTDRGRLPLF--EPPGDEFFGRYRDIVTARARRVPLQHLIGTVSFGPVVLHVGPGVFVPRPETEA 118
Cdd:TIGR00536  21 ENPWLEALLLLEHDLGRERDLLLAFltEELTPDEKERIFRLVLRRVKGVPVAYLLGSKEFYGLEFFVNEHVLIPRPETEE 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440   119 ILAWATAQSLPARPL--IVDACTGSGALAVALAQHRANlglkARIIGIDDSDCALDYARRNA----AGTPVELVRADvtt 192
Cdd:TIGR00536 101 LVEKALASLISQPPIlhILDLGTGSGCIALALAYEFPN----AEVIAVDISPDALAVAEENAeknqLEHRVEFIQSN--- 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440   193 prLLPELDG-QVDLMVSNPPYIP--DAAVLePEVAQHDPHHALFGGPDGMTVISAVVGLAGRWLRPGGLFAVEHDDTTSS 269
Cdd:TIGR00536 174 --LFEPLAGqKIDIIVSNPPYIDeeDLADL-PNVVRFEPLLALVGGDDGLNILRQIIELAPDYLKPNGFLVCEIGNWQQK 250

                         250       260       270
                  ....*....|....*....|....*....|..
gi 15608440   270 STVDLVSSTKLFVDVQARKDLAGRPRFVTAMR 301
Cdd:TIGR00536 251 SLKELLRIKFTWYDVENGRDLNGKERVVLGFY 282
PrmC_rel_meth TIGR03704
putative protein-(glutamine-N5) methyltransferase, unknown substrate-specific; This protein ...
 79-290 1.16e-25

putative protein-(glutamine-N5) methyltransferase, unknown substrate-specific; This protein family is closely related to two different families of protein-(glutamine-N5) methyltransferase. The first is PrmB, which modifies ribosomal protein L3 in some bacteria. The second is PrmC (HemK), which modifies peptide chain release factors 1 and 2 in most bacteria and also in eukaryotes. The glutamine side chain-binding motif NPPY shared by PrmB and PrmC is N[VAT]PY in this family. The protein substrate is unknown. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274733 [Multi-domain]  Cd Length: 251  Bit Score: 102.94  E-value: 1.16e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440    79 IVTARARRVPLQHLIGTVSFGPVVLHVGPGVFVPRPETEAI--LAWATAQSLPARPLIVDACTGSGALAVALAQHRANLG 156
Cdd:TIGR03704  33 MVDRRVAGLPLEHVLGWAEFCGLRIAVDPGVFVPRRRTEFLvdEAAALARPRSGTLVVVDLCCGSGAVGAALAAALDGIE 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440   157 LKAriigIDDSDCALDYARRNAAGTPVELVRADVTTPrLLPELDGQVDLMVSNPPYIPDAAV--LEPEVAQHDPHHALFG 234
Cdd:TIGR03704 113 LHA----ADIDPAAVRCARRNLADAGGTVHEGDLYDA-LPTALRGRVDILAANAPYVPTDAIalMPPEARDHEPRVALDG 187

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 15608440   235 GPDGMTVISAVVGLAGRWLRPGGLFAVEHDDTTSSSTVDLVSSTKLFVDVQARKDL 290
Cdd:TIGR03704 188 GADGLDVLRRVAAGAPDWLAPGGHLLVETSERQAPLAVEAFARAGLIARVASSEEL 243
PRK14966 PRK14966
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; ...
 70-305 2.28e-16

unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional


Pssm-ID: 184930 [Multi-domain]  Cd Length: 423  Bit Score: 79.35  E-value: 2.28e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440   70 DEFFGRYRDIVTARARRVPLQHLIGTVSFGPVVLHVGPGVFVPRPETEAILAWATAQsLPARPLIVDACTGSGALAVALA 149
Cdd:PRK14966 192 DEVRQRADRLAQRRLNGEPVAYILGVREFYGRRFAVNPNVLIPRPETEHLVEAVLAR-LPENGRVWDLGTGSGAVAVTVA 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440  150 QHRANLGLKARiigiDDSDCALDYARRNAA--GTPVELVRA---DVTTPRllpelDGQVDLMVSNPPYIPDAavlEPEVA 224
Cdd:PRK14966 271 LERPDAFVRAS----DISPPALETARKNAAdlGARVEFAHGswfDTDMPS-----EGKWDIIVSNPPYIENG---DKHLL 338

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440  225 QHD----PHHALFGGPDGMTVISAVVGLAGRWLRPGGLFAVEHdDTTSSSTVDLVSSTKLFVDVQARKDLAGRPRFVTAM 300
Cdd:PRK14966 339 QGDlrfePQIALTDFSDGLSCIRTLAQGAPDRLAEGGFLLLEH-GFDQGAAVRGVLAENGFSGVETLPDLAGLDRVTLGK 417


                 ....*
gi 15608440  301 RWGHL 305
Cdd:PRK14966 418 YMKHL 422
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 116-261 5.00e-16

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 75.95  E-value: 5.00e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440 116 TEAIL--AWATAQSlPARplIVDACTGSGALAVALAQHRANlglkARIIGID-DSDcALDYARRNAAGTP----VELVRA 188
Cdd:COG4123  24 TDAVLlaAFAPVKK-GGR--VLDLGTGTGVIALMLAQRSPG----ARITGVEiQPE-AAELARRNVALNGledrITVIHG 95

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15608440 189 DVTTPRLLPElDGQVDLMVSNPPYIPDAAVLEPEVAQHDP-HHALFGGpdgmtvISAVVGLAGRWLRPGGLFAV 261
Cdd:COG4123  96 DLKEFAAELP-PGSFDLVVSNPPYFKAGSGRKSPDEARAIaRHEDALT------LEDLIRAAARLLKPGGRFAL 162
PRK14967 PRK14967
putative methyltransferase; Provisional
 100-320 1.10e-15

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 74.70  E-value: 1.10e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440  100 PVVLHVGPGVFVPRPETEAILAWATAQSLPARPLIVDACTGSGALAVALAQHRAnlglkARIIGIDDSDCALDYARRNA- 178
Cdd:PRK14967   6 PDALLRAPGVYRPQEDTQLLADALAAEGLGPGRRVLDLCTGSGALAVAAAAAGA-----GSVTAVDISRRAVRSARLNAl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440  179 -AGTPVELVRADVTtpRLLPEldGQVDLMVSNPPYIPDAAvlePEVAQHDPHHALFGGPDGMTVISAVVGLAGRWLRPGG 257
Cdd:PRK14967  81 lAGVDVDVRRGDWA--RAVEF--RPFDVVVSNPPYVPAPP---DAPPSRGPARAWDAGPDGRAVLDRLCDAAPALLAPGG 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15608440  258 LFAVEHDDTTS-SSTVDLVSSTKLFVDVQARKDLAGRPRFVTAMRWghlplAGENGAIDPRQRR 320
Cdd:PRK14967 154 SLLLVQSELSGvERTLTRLSEAGLDAEVVASQWIPFGPVLRARAAW-----LERRGLLPPGQRE 212
PRK14968 PRK14968
putative methyltransferase; Provisional
 139-257 1.58e-11

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 62.22  E-value: 1.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440  139 TGSGALAVALAQhranlgLKARIIGIDDSDCALDYARRNA-----AGTPVELVRADVTTP-RllpelDGQVDLMVSNPPY 212
Cdd:PRK14968  32 TGSGIVAIVAAK------NGKKVVGVDINPYAVECAKCNAklnniRNNGVEVIRSDLFEPfR-----GDKFDVILFNPPY 100

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 15608440  213 IPdaavLEPEVAQHDP-HHALFGGPDGMTVISAVVGLAGRWLRPGG 257
Cdd:PRK14968 101 LP----TEEEEEWDDWlNYALSGGKDGREVIDRFLDEVGRYLKPGG 142
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 134-257 3.96e-11

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 58.73  E-value: 3.96e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440   134 IVDACTGSGALAVALAQHranlgLKARIIGIDDSDCALDYARRNAA--GTPVELVRADVTTprlLPELDGQVDLMVSNpp 211
Cdd:pfam13649   1 VLDLGCGTGRLTLALARR-----GGARVTGVDLSPEMLERARERAAeaGLNVEFVQGDAED---LPFPDGSFDLVVSS-- 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 15608440   212 yipdaAVLepevaqhdpHHalFGGPDGMTVISAVVglagRWLRPGG 257
Cdd:pfam13649  71 -----GVL---------HH--LPDPDLEAALREIA----RVLKPGG 96
PrmC_N pfam17827
PrmC N-terminal domain; This entry corresponds to the N-terminal alpha helical domain of the ...
 39-94 1.32e-10

PrmC N-terminal domain; This entry corresponds to the N-terminal alpha helical domain of the HemK protein. HemK is a methyltransferase enzyme that carries out the methylation of the N5 nitrogen of the glutamine found in the conserved GGQ motif of class-1 release factors.


Pssm-ID: 436073 [Multi-domain]  Cd Length: 71  Bit Score: 56.33  E-value: 1.32e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 15608440    39 GVDSARCDAEQLAAHLAGTDRGRLPLF--EPPGDEFFGRYRDIVTARARRVPLQHLIG 94
Cdd:pfam17827  14 GIESPRLDAELLLAHVLGLDRTDLLLHpeEELSEEELERFEELLERRAAGEPLQYILG 71
PRK01544 PRK01544
bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) ...
 83-262 1.95e-10

bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed


Pssm-ID: 234958 [Multi-domain]  Cd Length: 506  Bit Score: 61.42  E-value: 1.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440   83 RARRVPLQHLIGTVSFGPVVLHVGPGVFVPRPETE-----AILAWATAQSLPARPL--------------------IVDA 137
Cdd:PRK01544  66 RLKHEPIAYITGVKEFYSREFIVNKHVLIPRSDTEvlvdvVFQCHSRESGNPEKKQlnpcfrgndissncndkflnILEL 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440  138 CTGSGALAVALAQHRANlglkARIIGIDDSDCALDYARRNAAGTPVElVRADVTTPRLLPELDGQ-VDLMVSNPPYIPDA 216
Cdd:PRK01544 146 GTGSGCIAISLLCELPN----ANVIATDISLDAIEVAKSNAIKYEVT-DRIQIIHSNWFENIEKQkFDFIVSNPPYISHS 220

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 15608440  217 AVLEP--EVAQHDPHHALFGGPDGMTVISAVVGLAGRWLRPGGLFAVE 262
Cdd:PRK01544 221 EKSEMaiETINYEPSIALFAEEDGLQAYFIIAENAKQFLKPNGKIILE 268
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
134-263 1.24e-09

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 54.83  E-value: 1.24e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440 134 IVDACTGSGALAVALAQHRANlglkARIIGIDDSDCALDYARRNAAGtpVELVRADVTTprllPELDGQVDLMVSNppyi 213
Cdd:COG4106   5 VLDLGCGTGRLTALLAERFPG----ARVTGVDLSPEMLARARARLPN--VRFVVADLRD----LDPPEPFDLVVSN---- 70

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 15608440 214 pdaAVLepevaQHDPHHAlfggpdgmtvisAVVGLAGRWLRPGGLFAVEH 263
Cdd:COG4106  71 ---AAL-----HWLPDHA------------ALLARLAAALAPGGVLAVQV 100
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 125-262 4.20e-09

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 53.87  E-value: 4.20e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440 125 AQSLPARPLIVDACTGSGALAVALAQHRAnlglkaRIIGIDDSDCALDYARRNAAGTPVELVRADVTTprlLPELDGQVD 204
Cdd:COG2227  19 ARLLPAGGRVLDVGCGTGRLALALARRGA------DVTGVDISPEALEIARERAAELNVDFVQGDLED---LPLEDGSFD 89

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15608440 205 LMVSNppyipdaavlepEVAQHDPHHAlfggpdgmtvisAVVGLAGRWLRPGGLFAVE 262
Cdd:COG2227  90 LVICS------------EVLEHLPDPA------------ALLRELARLLKPGGLLLLS 123
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 134-257 4.20e-09

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 55.20  E-value: 4.20e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440 134 IVDACTGSGALAVALAQHRANlglkARIIGIDDSDCALDYARRNAA---GTPVELVRADVTTPrlLPelDGQVDLMVSNP 210
Cdd:COG2813  53 VLDLGCGYGVIGLALAKRNPE----ARVTLVDVNARAVELARANAAangLENVEVLWSDGLSG--VP--DGSFDLILSNP 124

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 15608440 211 PyIPDAAVLEPEVAqhdphHALFGGpdgmtvisavvglAGRWLRPGG 257
Cdd:COG2813 125 P-FHAGRAVDKEVA-----HALIAD-------------AARHLRPGG 152
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 134-262 6.47e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 50.12  E-value: 6.47e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440 134 IVDACTGSGALAVALAQHranlgLKARIIGIDDSDCALDYARRNAA---GTPVELVRADVTTprLLPELDGQVDLMVSNP 210
Cdd:cd02440   2 VLDLGCGTGALALALASG-----PGARVTGVDISPVALELARKAAAallADNVEVLKGDAEE--LPPEADESFDVIISDP 74

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 15608440 211 PYIPdaavlepevaqhdphhalfggpdGMTVISAVVGLAGRWLRPGGLFAVE 262
Cdd:cd02440  75 PLHH-----------------------LVEDLARFLEEARRLLKPGGVLVLT 103
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
133-211 1.48e-07

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 51.06  E-value: 1.48e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440 133 LIVDACTGSGALAVALAQHRAnlglkARIIGIDDSDCALDYARRNA--AGTPVELVRADVTTPrllpELDGQVDLMVSNP 210
Cdd:COG2263  48 TVLDLGCGTGMLAIGAALLGA-----KKVVGVDIDPEALEIARENAerLGVRVDFIRADVTRI----PLGGSVDTVVMNP 118


                .
gi 15608440 211 P 211
Cdd:COG2263 119 P 119
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 107-212 2.01e-07

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 49.95  E-value: 2.01e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440 107 PGVFVPRpeteaiLAWATAQ--SLPARPLIVDACTGSGALAVAlaqhRANLGlkARIIGIDDSDCALDYARRN---AAGT 181
Cdd:COG1041   7 PGSLDPR------LARALVNlaGAKEGDTVLDPFCGTGTILIE----AGLLG--RRVIGSDIDPKMVEGARENlehYGYE 74

                        90       100       110
                ....*....|....*....|....*....|.
gi 15608440 182 PVELVRADVTTprlLPELDGQVDLMVSNPPY 212
Cdd:COG1041  75 DADVIRGDARD---LPLADESVDAIVTDPPY 102
hemK_rel_arch TIGR00537
HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme ...
 139-290 4.37e-07

HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. This model represents an archaeal and eukaryotic protein family that lacks an N-terminal domain found in HemK and its eubacterial homologs. It is found in a single copy in the first six completed archaeal and eukaryotic genomes. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 129628 [Multi-domain]  Cd Length: 179  Bit Score: 49.47  E-value: 4.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440   139 TGSGALAVALAqhranlGLKARIIGIDDSDCALDYARRNAAGTPVELvraDVTTPRLLPELDGQVDLMVSNPPYIPdaav 218
Cdd:TIGR00537  28 AGTGLVAIRLK------GKGKCILTTDINPFAVKELRENAKLNNVGL---DVVMTDLFKGVRGKFDVILFNPPYLP---- 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15608440   219 LEPEVAQHD-PHHALFGGPDGMTVISAVVGLAGRWLRPGG-LFAVEHDDTTSSSTVDLVSSTKLFVDVQARKDL 290
Cdd:TIGR00537  95 LEDDLRRGDwLDVAIDGGKDGRKVIDRFLDELPEILKEGGrVQLIQSSLNGEPDTFDKLDERGFRYEIVAERGL 168
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 134-261 1.81e-06

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 46.91  E-value: 1.81e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440 134 IVDACTGSGALAVALAQHRanlglkARIIGIDDSDCALDYARRNA--AGTPVELVRADVTTprlLPELDGQVDLMVSNpp 211
Cdd:COG2226  26 VLDLGCGTGRLALALAERG------ARVTGVDISPEMLELARERAaeAGLNVEFVVGDAED---LPFPDGSFDLVISS-- 94

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 15608440 212 yipdaavlepEVAQHDPHHAlfggpdgmtvisAVVGLAGRWLRPGGLFAV 261
Cdd:COG2226  95 ----------FVLHHLPDPE------------RALAEIARVLKPGGRLVV 122
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 135-261 2.49e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 45.35  E-value: 2.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440   135 VDACTGSGALAVALAQHRAnlglkaRIIGIDDSDCALDYARRNAAGTPVELVRADVTTprlLPELDGQVDLMVSNppyip 214
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGA------RVTGVDISPEMLELAREKAPREGLTFVVGDAED---LPFPDNSFDLVLSS----- 66

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 15608440   215 daAVLepevaqhdpHHAlfggPDGMTVISAVVglagRWLRPGGLFAV 261
Cdd:pfam08241  67 --EVL---------HHV----EDPERALREIA----RVLKPGGILII 94
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 134-261 2.63e-06

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 46.46  E-value: 2.63e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440 134 IVDACTGSGALAVALAQHRanlglKARIIGIDDSDCALDYARRNAAGT----PVELVRADVttpRLLPElDGQVDLMVSN 209
Cdd:COG2230  55 VLDIGCGWGGLALYLARRY-----GVRVTGVTLSPEQLEYARERAAEAgladRVEVRLADY---RDLPA-DGQFDAIVSI 125

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 15608440 210 ppyipdaavlepEVAQHdphhalFGGPDGMTVISAVvglaGRWLRPGGLFAV 261
Cdd:COG2230 126 ------------GMFEH------VGPENYPAYFAKV----ARLLKPGGRLLL 155
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 74-211 4.76e-06

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 47.86  E-value: 4.76e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440  74 GRYRDIVTARARRVPlqhligTVSFGPVVLHVGPGVF--VPRPETEAILAWAT--AQSLPARpLIVDACTGSGALAVALA 149
Cdd:COG2265 180 GELRHLVVRAGRDYL------TERLGGLTFRISPGSFfqVNPEQAEALYAAALewLDLTGGE-RVLDLYCGVGTFALPLA 252

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15608440 150 QHRAnlglkaRIIGIDDSDCALDYARRNAAG---TPVELVRADVTtpRLLPELD--GQVDLMVSNPP 211
Cdd:COG2265 253 RRAK------KVIGVEIVPEAVEDARENARLnglKNVEFVAGDLE--EVLPELLwgGRPDVVVLDPP 311
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
115-267 7.37e-06

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 45.76  E-value: 7.37e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440 115 ETEAILAWATAQSLPARP--LIVDACTGSGALAVALAQHranlglKARIIGIDDSDCALDYARRNaaGTPVELVRADVTT 192
Cdd:COG4976  29 EAPALLAEELLARLPPGPfgRVLDLGCGTGLLGEALRPR------GYRLTGVDLSEEMLAKAREK--GVYDRLLVADLAD 100

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15608440 193 prlLPELDGQVDLMVSnppyipdAAVLepeVAQHDphhalfggpdgmtvISAVVGLAGRWLRPGGLFA--VEHDDTT 267
Cdd:COG4976 101 ---LAEPDGRFDLIVA-------ADVL---TYLGD--------------LAAVFAGVARALKPGGLFIfsVEDADGS 150
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 134-212 1.17e-05

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 45.04  E-value: 1.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440   134 IVDACTGSGALAVA---LAQHRANLGLKAR----IIGIDDSDCALDYARRNAA----GTPVELVRADVTTprlLPELDGQ 202
Cdd:pfam01170  32 LLDPMCGSGTILIEaalMGANIAPGKFDARvrapLYGSDIDRRMVQGARLNAEnagvGDLIEFVQADAAD---LPLLEGS 108

                          90
                  ....*....|
gi 15608440   203 VDLMVSNPPY 212
Cdd:pfam01170 109 VDVIVTNPPY 118
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 117-267 1.29e-05

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 45.29  E-value: 1.29e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440 117 EAILAWATAQSLPARPLIVDACTGSGALAVALAQHranlgLKARIIGIDDSDCALDYARRNAAG---TPVELVRADVTTP 193
Cdd:COG0500  13 GLAALLALLERLPKGGRVLDLGCGTGRNLLALAAR-----FGGRVIGIDLSPEAIALARARAAKaglGNVEFLVADLAEL 87

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15608440 194 RLLPelDGQVDLMVSNppyipdaavlepEVAQHDPHHalfggpdgmtVISAVVGLAGRWLRPGGLFAVEHDDTT 267
Cdd:COG0500  88 DPLP--AESFDLVVAF------------GVLHHLPPE----------EREALLRELARALKPGGVLLLSASDAA 137
YtxK COG0827
Adenine-specific DNA N6-methylase [Replication, recombination and repair];
134-240 1.43e-04

Adenine-specific DNA N6-methylase [Replication, recombination and repair];


Pssm-ID: 440589 [Multi-domain]  Cd Length: 327  Bit Score: 43.01  E-value: 1.43e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440 134 IVDACTGSGALAVALAQHranLGLKARIIGIDDSDCALDYARRNAA--GTPVELVRADVTTPRLLPeldgQVDLMVSNPP 211
Cdd:COG0827 119 ILDPAVGTGNLLTTVLNQ---LKKKVNAYGVEVDDLLIRLAAVLANlqGHPVELFHQDALQPLLID----PVDVVISDLP 191

                        90       100       110
                ....*....|....*....|....*....|.
gi 15608440 212 --YIPDAavlepEVAQHDPHHAlfggPDGMT 240
Cdd:COG0827 192 vgYYPND-----ERAKRFKLKA----DEGHS 213
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 125-257 1.66e-04

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 41.42  E-value: 1.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440   125 AQSLPARPL--IVDACTGSGALAVALAQHRAnlglKARIIGIDDSDCALDYARRNAA---GTPVELVRADVTTPRLlpel 199
Cdd:pfam05175  24 LEHLPKDLSgkVLDLGCGAGVLGAALAKESP----DAELTMVDINARALESARENLAangLENGEVVASDVYSGVE---- 95

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 15608440   200 DGQVDLMVSNPPYipdaavlepevaqHDPHHALFGgpdgmtVISAVVGLAGRWLRPGG 257
Cdd:pfam05175  96 DGKFDLIISNPPF-------------HAGLATTYN------VAQRFIADAKRHLRPGG 134
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 134-263 6.12e-04

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 39.71  E-value: 6.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15608440   134 IVDACTGSGALAVALAQhraNLGLKARIIGIDDSDCALDYARRNAAG---TPVELVRADVTTprlLPEL--DGQVDLMVS 208
Cdd:pfam13847   7 VLDLGCGTGHLSFELAE---ELGPNAEVVGIDISEEAIEKARENAQKlgfDNVEFEQGDIEE---LPELleDDKFDVVIS 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 15608440   209 NppyipdaavlepEVAQHDPHhalfggPDgmtvisAVVGLAGRWLRPGGLFAVEH 263
Cdd:pfam13847  81 N------------CVLNHIPD------PD------KVLQEILRVLKPGGRLIISD 111
rlmL PRK11783
bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2)) ...
 149-212 1.08e-03

bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL;


Pssm-ID: 236981 [Multi-domain]  Cd Length: 702  Bit Score: 40.56  E-value: 1.08e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15608440  149 AQHRANLGLK---ARIIGIDDSDCALDYARRNA--AGTP--VELVRADVTTprLLPELD-GQVDLMVSNPPY 212
Cdd:PRK11783 244 AQERARAGLAelpSKFYGSDIDPRVIQAARKNArrAGVAelITFEVKDVAD--LKNPLPkGPTGLVISNPPY 313
RlmL COG0116
23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA ...
 149-212 7.67e-03

23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA G2445 N2-methylase RlmL is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 439886 [Multi-domain]  Cd Length: 369  Bit Score: 37.77  E-value: 7.67e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15608440 149 AQHRANLGLKARIIGIDDSDCALDYARRNA--AGTP--VELVRADVTTprllPELDGQVDLMVSNPPY 212
Cdd:COG0116 241 AEARIKRDPPLPIFGSDIDPRAIEAARENAerAGVAdlIEFEQADFRD----LEPPAEPGLIITNPPY 304
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 139-209 9.88e-03

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 37.25  E-value: 9.88e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15608440   139 TGSGALAVALAQhranLGLKaRIIGIDDSDCALDYARRNAAGTPVELvRADVTTPRLLPEldGQVDLMVSN 209
Cdd:pfam06325 170 CGSGILAIAALK----LGAK-KVVGVDIDPVAVRAAKENAELNGVEA-RLEVYLPGDLPK--EKADVVVAN 232
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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