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Conserved domains on  [gi|15610319|ref|NP_217699|]
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transcriptional regulator [Mycobacterium tuberculosis H37Rv]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 11466506)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|2644244|8831795
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 21-97 3.88e-07

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


:

Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 44.24  E-value: 3.88e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15610319  21 DLQRAAVAREEMRDAvLAHRLAEIRKALGHaRQADVAALMGVSQARVSKLESGDLSHTeLGTLQAYVAALGGHLRIV 97
Cdd:COG3620   3 DLMSRDVVTVSPDDT-LGEALRLMRKELGL-SQLPVAELVGVSQSDILRIESGKRDPT-VSTLEKIAEALGKELSAV 76
 
Name Accession Description Interval E-value
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 21-97 3.88e-07

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 44.24  E-value: 3.88e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15610319  21 DLQRAAVAREEMRDAvLAHRLAEIRKALGHaRQADVAALMGVSQARVSKLESGDLSHTeLGTLQAYVAALGGHLRIV 97
Cdd:COG3620   3 DLMSRDVVTVSPDDT-LGEALRLMRKELGL-SQLPVAELVGVSQSDILRIESGKRDPT-VSTLEKIAEALGKELSAV 76
HTH_37 pfam13744
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain.
 35-99 4.42e-07

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain.


Pssm-ID: 433449 [Multi-domain]  Cd Length: 80  Bit Score: 43.75  E-value: 4.42e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15610319    35 AVLAHRLAEIRKALGhARQADVAALMGVSQARVSKLESGDLSHTELGTLQAYVAALGGHLRIVAE 99
Cdd:pfam13744  17 AQLARAIARLIEGRG-LSQQEAAALLGIAQPKVSALLKGKLSRFSLDKLLDFLTALGQDVEIVVK 80
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
40-95 1.36e-06

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 42.12  E-value: 1.36e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 15610319     40 RLAEIRKALGHaRQADVAALMGVSQARVSKLESGDLSHTeLGTLQAYVAALGGHLR 95
Cdd:smart00530   1 RLKELREEKGL-TQEELAEKLGVSRSTLSRIENGKRKPS-LETLKKLAKALGVSLD 54
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 38-91 1.88e-05

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 39.07  E-value: 1.88e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 15610319  38 AHRLAEIRKALGHaRQADVAALMGVSQARVSKLESGDlSHTELGTLQAYVAALG 91
Cdd:cd00093   1 GERLKELRKEKGL-TQEELAEKLGVSRSTISRIENGK-RNPSLETLEKLAKALG 52
PRK09706 PRK09706
transcriptional repressor DicA; Reviewed
 32-74 9.37e-03

transcriptional repressor DicA; Reviewed


Pssm-ID: 182039 [Multi-domain]  Cd Length: 135  Bit Score: 33.29  E-value: 9.37e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 15610319   32 MRDAVLAHRLAEIRKALGHArQADVAALMGVSQARVSKLESGD 74
Cdd:PRK09706   1 MKNLTLGQRIRYRRKQLKLS-QRSLAKAVKVSHVSISQWERDE 42
 
Name Accession Description Interval E-value
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 21-97 3.88e-07

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 44.24  E-value: 3.88e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15610319  21 DLQRAAVAREEMRDAvLAHRLAEIRKALGHaRQADVAALMGVSQARVSKLESGDLSHTeLGTLQAYVAALGGHLRIV 97
Cdd:COG3620   3 DLMSRDVVTVSPDDT-LGEALRLMRKELGL-SQLPVAELVGVSQSDILRIESGKRDPT-VSTLEKIAEALGKELSAV 76
HTH_37 pfam13744
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain.
 35-99 4.42e-07

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain.


Pssm-ID: 433449 [Multi-domain]  Cd Length: 80  Bit Score: 43.75  E-value: 4.42e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15610319    35 AVLAHRLAEIRKALGhARQADVAALMGVSQARVSKLESGDLSHTELGTLQAYVAALGGHLRIVAE 99
Cdd:pfam13744  17 AQLARAIARLIEGRG-LSQQEAAALLGIAQPKVSALLKGKLSRFSLDKLLDFLTALGQDVEIVVK 80
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
40-95 1.36e-06

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 42.12  E-value: 1.36e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 15610319     40 RLAEIRKALGHaRQADVAALMGVSQARVSKLESGDLSHTeLGTLQAYVAALGGHLR 95
Cdd:smart00530   1 RLKELREEKGL-TQEELAEKLGVSRSTLSRIENGKRKPS-LETLKKLAKALGVSLD 54
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
34-91 2.58e-06

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 41.91  E-value: 2.58e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15610319  34 DAVLAHRLAEIRKALGHaRQADVAALMGVSQARVSKLESGDLSHTeLGTLQAYVAALG 91
Cdd:COG1396   5 KKALGERLRELRKARGL-TQEELAERLGVSRSTISRIERGRRNPS-LETLLKLAKALG 60
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 38-91 1.88e-05

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 39.07  E-value: 1.88e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 15610319  38 AHRLAEIRKALGHaRQADVAALMGVSQARVSKLESGDlSHTELGTLQAYVAALG 91
Cdd:cd00093   1 GERLKELRKEKGL-TQEELAEKLGVSRSTISRIENGK-RNPSLETLEKLAKALG 52
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 41-95 2.25e-05

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 38.68  E-value: 2.25e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 15610319    41 LAEIRKALGHaRQADVAALMGVSQARVSKLESGDlSHTELGTLQAYVAALGGHLR 95
Cdd:pfam01381   1 LKELREELGL-SQEELAEKLGVSRSTISKIENGK-REPSLETLKKLAEALGVSLD 53
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
37-91 2.58e-04

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 36.36  E-value: 2.58e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15610319  37 LAHRLAEIRKALGHaRQADVAALMGVSQARVSKLESGDlSHTELGTLQAYVAALG 91
Cdd:COG1476   5 LGNRLKELRKERGL-TQEELAELLGVSRQTISAIENGK-YNPSLELALKIARALG 57
COG5606 COG5606
Predicted DNA-binding protein, XRE-type HTH domain [General function prediction only];
42-97 5.46e-04

Predicted DNA-binding protein, XRE-type HTH domain [General function prediction only];


Pssm-ID: 444337  Cd Length: 105  Bit Score: 36.40  E-value: 5.46e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15610319  42 AEIRKALGHAR--QADVAALMGVSQARVSKLESGDLSHTELGTLQAYVAALGGHLRIV 97
Cdd:COG5606  35 AAIRKLIKERGltQAEAAELLGITQPRVSDLLRGKISKFSLDKLVNMLARLGQDVEIV 92
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 37-91 5.76e-03

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 32.89  E-value: 5.76e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 15610319    37 LAHRLAEIRKALGhARQADVAALMGVSQARVSKLESGDLSHTELGTLQAYVAALG 91
Cdd:pfam13560   2 LGARLRRLRERAG-LSQEALARRLGVSRSTLSRLETGRRGRPSPAVVERLARALG 55
PRK09706 PRK09706
transcriptional repressor DicA; Reviewed
 32-74 9.37e-03

transcriptional repressor DicA; Reviewed


Pssm-ID: 182039 [Multi-domain]  Cd Length: 135  Bit Score: 33.29  E-value: 9.37e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 15610319   32 MRDAVLAHRLAEIRKALGHArQADVAALMGVSQARVSKLESGD 74
Cdd:PRK09706   1 MKNLTLGQRIRYRRKQLKLS-QRSLAKAVKVSHVSISQWERDE 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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