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Conserved domains on  [gi|15610356|ref|NP_217736|]
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two component sensor kinase [Mycobacterium tuberculosis H37Rv]

Protein Classification

sensor histidine kinase( domain architecture ID 11467609)

two-component sensor histidine kinase functions as a protein kinase that phosphorylates a target protein in response to one of a variety of signals, similar to Brucella abortus blue-light-activated histidine kinase

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0000155|GO:0004673|GO:0007165|GO:0005524
PubMed:  10339418|10637609
SCOP:  4001957

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 1-498 1.36e-58

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


:

Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 201.67  E-value: 1.36e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356   1 MSTLGDLLAEHTVLPGSAVDHLHAVVGEWQLLADLSFADYLMWVRRDDGVLVCVAQCRPNTGPTVVHTDAVGTVVAANSM 80
Cdd:COG3920   3 LALLLLLLLALAALLLLAALLLLAAALLLALLALLLLALLLLALLLASALLALLALSAAALAAALAVALAAAVGAAAALL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356  81 PLVAATFSGGVPGREGAVGQQNSCQHDGHSVEVSPVRFGDQVVAVLTRHQPELAARRRSGHLETAYRLCATDLLRMLAEG 160
Cdd:COG3920  83 ALLVLLLLLLLAAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAALLL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 161 TFPDAGDVAMSRSSPRAGDGFIRLDVDGVVSYASPNALSAYHRMGLTTELEGVNLIDATRPLISDPFEAHEVDEHVQDLL 240
Cdd:COG3920 163 LAEELAALRLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELE 242

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 241 agdgkGMRMEVDAGGATVLLRTLPLVVAGRNVGAAILIRDVTEVKRRDRALIS----KDATIREIHHRVKNNLQTVAALL 316
Cdd:COG3920 243 -----RRRRARGLGRLLLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEAsleeKELLLRELHHRVKNNLQVVSSLL 317

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 317 RLQARRTSNAEGREALIESVRRVSSIALVHDALSMSVD-EQVNLDEVIDRILPIMNDVASvDRPIRINRVGDLGVLDSDR 395
Cdd:COG3920 318 RLQARRADDPEAREALEESQNRIQALALVHELLYQSEDwEGVDLRDYLRELLEPLRDSYG-GRGIRIELDGPDVELPADA 396

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 396 ATALIMVITELVQNAIEHAFdPAAAEGSVTIRAERSARWLDVVVHDDGLGLPQGFSLEKSDSLGLQIVRTLVSaELDGSL 475
Cdd:COG3920 397 AVPLGLILNELVTNALKHAF-LSGEGGRIRVSWRREDGRLRLTVSDNGVGLPEDVDPPARKGLGLRLIRALVR-QLGGTL 474

                       490       500
                ....*....|....*....|...
gi 15610356 476 GMRdaRERGTDVVLRVPVGRRGR 498
Cdd:COG3920 475 ELD--RPEGTRVRITFPLAELAA 495
 
Name Accession Description Interval E-value
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 1-498 1.36e-58

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 201.67  E-value: 1.36e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356   1 MSTLGDLLAEHTVLPGSAVDHLHAVVGEWQLLADLSFADYLMWVRRDDGVLVCVAQCRPNTGPTVVHTDAVGTVVAANSM 80
Cdd:COG3920   3 LALLLLLLLALAALLLLAALLLLAAALLLALLALLLLALLLLALLLASALLALLALSAAALAAALAVALAAAVGAAAALL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356  81 PLVAATFSGGVPGREGAVGQQNSCQHDGHSVEVSPVRFGDQVVAVLTRHQPELAARRRSGHLETAYRLCATDLLRMLAEG 160
Cdd:COG3920  83 ALLVLLLLLLLAAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAALLL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 161 TFPDAGDVAMSRSSPRAGDGFIRLDVDGVVSYASPNALSAYHRMGLTTELEGVNLIDATRPLISDPFEAHEVDEHVQDLL 240
Cdd:COG3920 163 LAEELAALRLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELE 242

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 241 agdgkGMRMEVDAGGATVLLRTLPLVVAGRNVGAAILIRDVTEVKRRDRALIS----KDATIREIHHRVKNNLQTVAALL 316
Cdd:COG3920 243 -----RRRRARGLGRLLLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEAsleeKELLLRELHHRVKNNLQVVSSLL 317

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 317 RLQARRTSNAEGREALIESVRRVSSIALVHDALSMSVD-EQVNLDEVIDRILPIMNDVASvDRPIRINRVGDLGVLDSDR 395
Cdd:COG3920 318 RLQARRADDPEAREALEESQNRIQALALVHELLYQSEDwEGVDLRDYLRELLEPLRDSYG-GRGIRIELDGPDVELPADA 396

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 396 ATALIMVITELVQNAIEHAFdPAAAEGSVTIRAERSARWLDVVVHDDGLGLPQGFSLEKSDSLGLQIVRTLVSaELDGSL 475
Cdd:COG3920 397 AVPLGLILNELVTNALKHAF-LSGEGGRIRVSWRREDGRLRLTVSDNGVGLPEDVDPPARKGLGLRLIRALVR-QLGGTL 474

                       490       500
                ....*....|....*....|...
gi 15610356 476 GMRdaRERGTDVVLRVPVGRRGR 498
Cdd:COG3920 475 ELD--RPEGTRVRITFPLAELAA 495
HATPase_EL346-LOV-HK-like cd16951
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 359-492 1.85e-52

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.


Pssm-ID: 340427 [Multi-domain]  Cd Length: 131  Bit Score: 173.76  E-value: 1.85e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 359 LDEVIDRILPIMNDVASvDRPIRINRVGDLGVLDSDRATALIMVITELVQNAIEHAFDPAAaEGSVTIRAERSARWLDVV 438
Cdd:cd16951   1 LGEYINRIASAINAIHA-VGDIRINITGDTGPVSSEVATAIGLVVNELLQNALKHAFSDRE-GGTITIRSVVDGDYLRIT 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 15610356 439 VHDDGLGLPQGFSLEKSDSLGLQIVRTLVSAELDGsLGMRDARERGTDVVLRVP 492
Cdd:cd16951  79 VIDDGVGLPQDEDWPNKGSLGLQIVRSLVEGELKA-FLEVQSAENGTRVNIDIP 131
PdtaS_GAF pfam12282
Histidine kinase PdtaS, GAF domain; This entry represents the GAF domain of the sensor region ...
 9-150 4.15e-48

Histidine kinase PdtaS, GAF domain; This entry represents the GAF domain of the sensor region in the cytosolic histidine kinase (HK), PdtaS, from Mycobacterium tuberculosis. The N-terminal region of this protein is comprised of closely linked GAF and PAS domains, both are ubiquitous and form dimeric interfaces. GAF domains are known to bind heme (as can PAS domains), to be involved in redox responses and even to function as catalytic domains.


Pssm-ID: 432452  Cd Length: 140  Bit Score: 162.79  E-value: 4.15e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356     9 AEHTVLPGSAVDHLHAVVGEWQLLADLSFADYLMWVR-RDDGVLVCVAQCRPNTGPTVVHTDAVGTVVAANSMPLVAATF 87
Cdd:pfam12282   1 AEHTDLSDADIEWLHRLVGDWQLLADLSFADLFLWVPtDDDDGAVVVAQARPTTGPTLYPDDVVGEVALRENEPLVLRAL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15610356    88 SGGVPGREGAVGQQNSCQHDGhsVEVSPVRFGDQVVAVLTRHQpELAARRRSGHLETAYRLCA 150
Cdd:pfam12282  81 ETGRIRREKAPGWSGGTRPVR--QEAVPVRRRGRVIAVLIRET-NLSADRTPSRLEEAYLETA 140
PRK13560 PRK13560
hypothetical protein; Provisional
 277-497 6.52e-32

hypothetical protein; Provisional


Pssm-ID: 106506 [Multi-domain]  Cd Length: 807  Bit Score: 130.18  E-value: 6.52e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356  277 LIRDVTEVK----RRDRALISKDATIREIHHRVKNNLQTVAALLRLQARRTSNAEGREALIESVRRVSSIALVHDALSMS 352
Cdd:PRK13560 584 IVIDISERKhaeeKIKAALTEKEVLLKEIHHRVKNNLQIISSLLDLQAEKLHDEEAKCAFAESQDRICAMALAHEKLYQS 663

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356  353 VD-EQVNLDEVIDRILP-IMNDVASVDRPIRINRVGDLGVLDSDRATALIMVITELVQNAIEHAFdPAAAEGSVTIRAER 430
Cdd:PRK13560 664 EDlADIDFLDYIESLTAhLKNSFAIDFGRIDCKIDADDGCLDIDKAIPCGLIISELLSNALKHAF-PDGAAGNIKVEIRE 742

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15610356  431 SAR-WLDVVVHDDGLGLPQGFSLEKSDSLGLQIVRTLVSaELDGSLGMrDAReRGTDVVLRVPVGRRG 497
Cdd:PRK13560 743 QGDgMVNLCVADDGIGLPAGFDFRAAETLGLQLVCALVK-QLDGEIAL-DSR-GGARFNIRFPMSPAG 807
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 396-493 3.36e-12

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 63.05  E-value: 3.36e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356    396 ATALIMVITELVQNAIEHAFdpaaAEGSVTIRAERSARWLDVVVHDDGLGLPQ---------GFSLEKSDS------LGL 460
Cdd:smart00387   3 PDRLRQVLSNLLDNAIKYTP----EGGRITVTLERDGDHVEITVEDNGPGIPPedlekifepFFRTDKRSRkiggtgLGL 78

                           90       100       110
                   ....*....|....*....|....*....|...
gi 15610356    461 QIVRTLVSAeLDGSLGMRDARERGTDVVLRVPV 493
Cdd:smart00387  79 SIVKKLVEL-HGGEISVESEPGGGTTFTITLPL 110
sensory_box TIGR00229
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...
 177-291 2.05e-03

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]


Pssm-ID: 272971 [Multi-domain]  Cd Length: 124  Bit Score: 38.04  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356   177 AGDGFIRLDVDGVVSYASPnalsAYHRM-GLT-TELEGVNLIDatrpLISDPFEAhEVDEHVQDLLAGDGKGMRMEV--- 251
Cdd:TIGR00229  12 SPDAIIVIDLEGNILYVNP----AFEEIfGYSaEELIGRNVLE----LIPEEDRE-EVRERIERRLEGEPEPVSEERrvr 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 15610356   252 --DAGGATVLLRTLPLVVAGRNVGAAILIRDVTEVKRRDRAL 291
Cdd:TIGR00229  83 rkDGSEIWVEVSVSPIRTNGGELGVVGIVRDITERKEAEEAL 124
 
Name Accession Description Interval E-value
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 1-498 1.36e-58

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 201.67  E-value: 1.36e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356   1 MSTLGDLLAEHTVLPGSAVDHLHAVVGEWQLLADLSFADYLMWVRRDDGVLVCVAQCRPNTGPTVVHTDAVGTVVAANSM 80
Cdd:COG3920   3 LALLLLLLLALAALLLLAALLLLAAALLLALLALLLLALLLLALLLASALLALLALSAAALAAALAVALAAAVGAAAALL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356  81 PLVAATFSGGVPGREGAVGQQNSCQHDGHSVEVSPVRFGDQVVAVLTRHQPELAARRRSGHLETAYRLCATDLLRMLAEG 160
Cdd:COG3920  83 ALLVLLLLLLLAAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAALLL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 161 TFPDAGDVAMSRSSPRAGDGFIRLDVDGVVSYASPNALSAYHRMGLTTELEGVNLIDATRPLISDPFEAHEVDEHVQDLL 240
Cdd:COG3920 163 LAEELAALRLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELE 242

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 241 agdgkGMRMEVDAGGATVLLRTLPLVVAGRNVGAAILIRDVTEVKRRDRALIS----KDATIREIHHRVKNNLQTVAALL 316
Cdd:COG3920 243 -----RRRRARGLGRLLLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEAsleeKELLLRELHHRVKNNLQVVSSLL 317

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 317 RLQARRTSNAEGREALIESVRRVSSIALVHDALSMSVD-EQVNLDEVIDRILPIMNDVASvDRPIRINRVGDLGVLDSDR 395
Cdd:COG3920 318 RLQARRADDPEAREALEESQNRIQALALVHELLYQSEDwEGVDLRDYLRELLEPLRDSYG-GRGIRIELDGPDVELPADA 396

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 396 ATALIMVITELVQNAIEHAFdPAAAEGSVTIRAERSARWLDVVVHDDGLGLPQGFSLEKSDSLGLQIVRTLVSaELDGSL 475
Cdd:COG3920 397 AVPLGLILNELVTNALKHAF-LSGEGGRIRVSWRREDGRLRLTVSDNGVGLPEDVDPPARKGLGLRLIRALVR-QLGGTL 474

                       490       500
                ....*....|....*....|...
gi 15610356 476 GMRdaRERGTDVVLRVPVGRRGR 498
Cdd:COG3920 475 ELD--RPEGTRVRITFPLAELAA 495
HATPase_EL346-LOV-HK-like cd16951
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 359-492 1.85e-52

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.


Pssm-ID: 340427 [Multi-domain]  Cd Length: 131  Bit Score: 173.76  E-value: 1.85e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 359 LDEVIDRILPIMNDVASvDRPIRINRVGDLGVLDSDRATALIMVITELVQNAIEHAFDPAAaEGSVTIRAERSARWLDVV 438
Cdd:cd16951   1 LGEYINRIASAINAIHA-VGDIRINITGDTGPVSSEVATAIGLVVNELLQNALKHAFSDRE-GGTITIRSVVDGDYLRIT 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 15610356 439 VHDDGLGLPQGFSLEKSDSLGLQIVRTLVSAELDGsLGMRDARERGTDVVLRVP 492
Cdd:cd16951  79 VIDDGVGLPQDEDWPNKGSLGLQIVRSLVEGELKA-FLEVQSAENGTRVNIDIP 131
PdtaS_GAF pfam12282
Histidine kinase PdtaS, GAF domain; This entry represents the GAF domain of the sensor region ...
 9-150 4.15e-48

Histidine kinase PdtaS, GAF domain; This entry represents the GAF domain of the sensor region in the cytosolic histidine kinase (HK), PdtaS, from Mycobacterium tuberculosis. The N-terminal region of this protein is comprised of closely linked GAF and PAS domains, both are ubiquitous and form dimeric interfaces. GAF domains are known to bind heme (as can PAS domains), to be involved in redox responses and even to function as catalytic domains.


Pssm-ID: 432452  Cd Length: 140  Bit Score: 162.79  E-value: 4.15e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356     9 AEHTVLPGSAVDHLHAVVGEWQLLADLSFADYLMWVR-RDDGVLVCVAQCRPNTGPTVVHTDAVGTVVAANSMPLVAATF 87
Cdd:pfam12282   1 AEHTDLSDADIEWLHRLVGDWQLLADLSFADLFLWVPtDDDDGAVVVAQARPTTGPTLYPDDVVGEVALRENEPLVLRAL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15610356    88 SGGVPGREGAVGQQNSCQHDGhsVEVSPVRFGDQVVAVLTRHQpELAARRRSGHLETAYRLCA 150
Cdd:pfam12282  81 ETGRIRREKAPGWSGGTRPVR--QEAVPVRRRGRVIAVLIRET-NLSADRTPSRLEEAYLETA 140
PRK13560 PRK13560
hypothetical protein; Provisional
 277-497 6.52e-32

hypothetical protein; Provisional


Pssm-ID: 106506 [Multi-domain]  Cd Length: 807  Bit Score: 130.18  E-value: 6.52e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356  277 LIRDVTEVK----RRDRALISKDATIREIHHRVKNNLQTVAALLRLQARRTSNAEGREALIESVRRVSSIALVHDALSMS 352
Cdd:PRK13560 584 IVIDISERKhaeeKIKAALTEKEVLLKEIHHRVKNNLQIISSLLDLQAEKLHDEEAKCAFAESQDRICAMALAHEKLYQS 663

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356  353 VD-EQVNLDEVIDRILP-IMNDVASVDRPIRINRVGDLGVLDSDRATALIMVITELVQNAIEHAFdPAAAEGSVTIRAER 430
Cdd:PRK13560 664 EDlADIDFLDYIESLTAhLKNSFAIDFGRIDCKIDADDGCLDIDKAIPCGLIISELLSNALKHAF-PDGAAGNIKVEIRE 742

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15610356  431 SAR-WLDVVVHDDGLGLPQGFSLEKSDSLGLQIVRTLVSaELDGSLGMrDAReRGTDVVLRVPVGRRG 497
Cdd:PRK13560 743 QGDgMVNLCVADDGIGLPAGFDFRAAETLGLQLVCALVK-QLDGEIAL-DSR-GGARFNIRFPMSPAG 807
HisKA_2 pfam07568
Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of ...
 300-367 7.33e-26

Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with pfam00512 and pfam07536. It is usually found adjacent to a C-terminal ATPase domain (pfam02518). This domain is found in a wide range of Bacteria and also several Archaea.


Pssm-ID: 400108 [Multi-domain]  Cd Length: 76  Bit Score: 100.28  E-value: 7.33e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15610356   300 EIHHRVKNNLQTVAALLRLQARRTSNAEGREALIESVRRVSSIALVHDALSMSVD-EQVNLDEVIDRIL 367
Cdd:pfam07568   1 EIHHRVKNNLQIISSLLRLQARRAKDEEVKEALRESQNRIRSMALIHEELYKSEDlDRIDFSEYLEKLT 69
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 217-496 8.89e-18

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 85.29  E-value: 8.89e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 217 DATRPLISDPFEAHEVDEHVQDLLAGDGkgMRMEVDAGGATVLLRTLPLVVAGRNVGAAILIRDVTEVKRRDRALISKDA 296
Cdd:COG3290 111 DAARRLLGLDAIGRPIDEVLAEVLETGE--RDEEILLNGRVLVVNRVPIRDDGRVVGAVATFRDRTELERLEEELEGVKE 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 297 ---TIREIHHRVKNNLQTVAALLRL----QARR--TSNAEGREALIESVRRVSSI----ALVHDALSMSVDEQVNLDEVI 363
Cdd:COG3290 189 laeALRAQRHDFRNHLHTISGLLQLgeydEALEyiDEISEELQELIDSLLSRIGNpvlaALLLGKAARARERGIDLTIDI 268

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 364 DRILPimndvasvdrpirinrvgDLGVLDSDrataLIMVITELVQNAIEHAFDPAAAEGSVTIRAERSARWLDVVVHDDG 443
Cdd:COG3290 269 DSDLP------------------DLPLSDTD----LVTILGNLLDNAIEAVEKLPEEERRVELSIRDDGDELVIEVEDSG 326

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15610356 444 LGLP---------QGFSLEKSDS--LGLQIVRTLVsAELDGSLGMRDARERGTDVVLRVPVGRR 496
Cdd:COG3290 327 PGIPeellekifeRGFSTKLGEGrgLGLALVKQIV-EKYGGTIEVESEEGEGTVFTVRLPKEGE 389
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 179-497 1.70e-16

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 81.55  E-value: 1.70e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 179 DGFIRLDVDGVVSYASPNAlsayhrmgltTELEGVNLIDATRPLISDPFEAHEVDEHVQDLLAGDGKGMRMEVDAGGATV 258
Cdd:COG5000 101 AGVIVLDADGRITLANPAA----------ERLLGIPLEELIGKPLEELLPELDLAELLREALERGWQEEIELTRDGRRTL 170

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 259 LLRTLPLvvagRNVGAAILIRDVTEVKRRDRAliskdATIRE----IHHRVKNNL---QTVAALLR--LQARRTSNAEGR 329
Cdd:COG5000 171 LVRASPL----RDDGYVIVFDDITELLRAERL-----AAWGElarrIAHEIKNPLtpiQLSAERLRrkLADKLEEDREDL 241

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 330 EALIES-VRRVSSIA-LVHDALSMS-----VDEQVNLDEVIDRILPIM-NDVASVDRPIRINRVGDLGVLDSDRaTALIM 401
Cdd:COG5000 242 ERALDTiIRQVDRLKrIVDEFLDFArlpepQLEPVDLNELLREVLALYePALKEKDIRLELDLDPDLPEVLADR-DQLEQ 320

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 402 VITELVQNAIEHAfdpaAAEGSVTIRAERSARWLDVVVHDDGLGLPQG---------FSlEKSDS--LGLQIVRTLVSaE 470
Cdd:COG5000 321 VLINLLKNAIEAI----EEGGEIEVSTRREDGRVRIEVSDNGPGIPEEvlerifepfFT-TKPKGtgLGLAIVKKIVE-E 394

                       330       340
                ....*....|....*....|....*..
gi 15610356 471 LDGSLGMRDARERGTDVVLRVPVGRRG 497
Cdd:COG5000 395 HGGTIELESRPGGGTTFTIRLPLAEEA 421
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
196-494 2.69e-16

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 79.95  E-value: 2.69e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 196 NALSAYHRMGLTTELEGVNLIDATRPLISDPFEAHEVDEHVQDLLAGDGKGMRMEVDAGGATVLLRTLPLVVAGRNVGAA 275
Cdd:COG0642  12 LLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 276 ILIRDVTEVKRRDRALISKDATIREIHHRVKNNLQTVAALLRLqARRTSNAEGREAL---IESVRRVSsiALVHDALSMS 352
Cdd:COG0642  92 LLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLEL-LLEELDEEQREYLetiLRSADRLL--RLINDLLDLS 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 353 ---------VDEQVNLDEVIDRILPIMNDVASVDR-PIRINRVGDLGVLDSDRaTALIMVITELVQNAIEHAfdpaAAEG 422
Cdd:COG0642 169 rleagklelEPEPVDLAELLEEVVELFRPLAEEKGiELELDLPDDLPTVRGDP-DRLRQVLLNLLSNAIKYT----PEGG 243

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 423 SVTIRAERSARWLDVVVHDDGLGLPQ---------GFSLEKSDS-----LGLQIVRTLVSAeLDGSLGMRDARERGTDVV 488
Cdd:COG0642 244 TVTVSVRREGDRVRISVEDTGPGIPPedlerifepFFRTDPSRRgggtgLGLAIVKRIVEL-HGGTIEVESEPGKGTTFT 322


                ....*.
gi 15610356 489 LRVPVG 494
Cdd:COG0642 323 VTLPLA 328
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
277-493 6.52e-16

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 77.25  E-value: 6.52e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 277 LIRDVTEVKRRDRAlisKDATIREIHHRVKNNLQTVAALL-RLQARRTSNAEGREALIESVRRVSS--IALVHDALSMS- 352
Cdd:COG2205   2 LEEALEELEELERL---KSEFLANVSHELRTPLTSILGAAeLLLDEEDLSPEERRELLEIIRESAErlLRLIEDLLDLSr 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 353 --------VDEQVNLDEVIDRILPIMNDVA-SVDRPIRINRVGDLGVLDSDRaTALIMVITELVQNAIEHAfdpaAAEGS 423
Cdd:COG2205  79 lesgklslELEPVDLAELLEEAVEELRPLAeEKGIRLELDLPPELPLVYADP-ELLEQVLANLLDNAIKYS----PPGGT 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 424 VTIRAERSARWLDVVVHDDGLGLPQG---------FSLEKSDS-----LGLQIVRTLVSAeLDGSLGMRDARERGTDVVL 489
Cdd:COG2205 154 ITISARREGDGVRISVSDNGPGIPEEeleriferfYRGDNSRGeggtgLGLAIVKRIVEA-HGGTIWVESEPGGGTTFTV 232


                ....
gi 15610356 490 RVPV 493
Cdd:COG2205 233 TLPL 236
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
169-448 8.97e-16

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 78.73  E-value: 8.97e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 169 AMSRSSPR-------AGDGFIRLDVDGVVSYASPNA--LSAYHRmgltTELEGVNLidatRPLISdpfEAHEVDEHVQDL 239
Cdd:COG3852   1 ALRESEELlraildsLPDAVIVLDADGRITYVNPAAerLLGLSA----EELLGRPL----AELFP---EDSPLRELLERA 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 240 LAGDGKGMRMEVDAGGA-----TVLLRTLPLVVAGRNVGAAILIRDVTEVKRRDRALI--SKDATIRE----IHHRVKNN 308
Cdd:COG3852  70 LAEGQPVTEREVTLRRKdgeerPVDVSVSPLRDAEGEGGVLLVLRDITERKRLERELRraEKLAAVGElaagLAHEIRNP 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 309 LQTVAALLRLQARRTSNAEGREAL---IESVRRVSSiaLVHDALSMSVD-----EQVNLDEVIDRILPIMNdvASVDRPI 380
Cdd:COG3852 150 LTGIRGAAQLLERELPDDELREYTqliIEEADRLNN--LVDRLLSFSRPrpperEPVNLHEVLERVLELLR--AEAPKNI 225

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15610356 381 RINR--VGDLGVLDSDRaTALIMVITELVQNAIEHAFDP------AAAEGSVTIRAERSARWLDVVVHDDGLGLPQ 448
Cdd:COG3852 226 RIVRdyDPSLPEVLGDP-DQLIQVLLNLVRNAAEAMPEGgtitirTRVERQVTLGGLRPRLYVRIEVIDNGPGIPE 300
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 396-493 3.36e-12

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 63.05  E-value: 3.36e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356    396 ATALIMVITELVQNAIEHAFdpaaAEGSVTIRAERSARWLDVVVHDDGLGLPQ---------GFSLEKSDS------LGL 460
Cdd:smart00387   3 PDRLRQVLSNLLDNAIKYTP----EGGRITVTLERDGDHVEITVEDNGPGIPPedlekifepFFRTDKRSRkiggtgLGL 78

                           90       100       110
                   ....*....|....*....|....*....|...
gi 15610356    461 QIVRTLVSAeLDGSLGMRDARERGTDVVLRVPV 493
Cdd:smart00387  79 SIVKKLVEL-HGGEISVESEPGGGTTFTITLPL 110
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
299-496 2.79e-11

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 63.87  E-value: 2.79e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 299 REIHHRVknnLQTVAAL-LRLQARRTSNAEGREALIESVRRVSSIA---------LVHDaLSMSVDEQVNLDEVIDRILP 368
Cdd:COG4585  59 RELHDGV---GQSLSAIkLQLEAARRLLDADPEAAREELEEIRELArealaelrrLVRG-LRPPALDDLGLAAALEELAE 134

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 369 IMNDVASVdrPIRINRVGDLGVLDSDRATALIMVITELVQNAIEHAfdpAAAEgsVTIRAERSARWLDVVVHDDGLGLPQ 448
Cdd:COG4585 135 RLLRAAGI--RVELDVDGDPDRLPPEVELALYRIVQEALTNALKHA---GATR--VTVTLEVDDGELTLTVRDDGVGFDP 207

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 15610356 449 GfsLEKSDSLGLQIVRTLVSAeLDGSLGMRDARERGTDVVLRVPVGRR 496
Cdd:COG4585 208 E--AAPGGGLGLRGMRERAEA-LGGTLTIGSAPGGGTRVRATLPLAAA 252
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
391-467 1.59e-10

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 58.77  E-value: 1.59e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 391 LDSDRATALIMVITELVQNAIEHAFdPAAAEGSVTIRAERSARWLDVVVHDDGLG-----LPQGFSLEKSDSLGLQIVRT 465
Cdd:COG2172  27 LDEDDADDLVLAVSEAVTNAVRHAY-GGDPDGPVEVELELDPDGLEIEVRDEGPGfdpedLPDPYSTLAEGGRGLFLIRR 105


                ..
gi 15610356 466 LV 467
Cdd:COG2172 106 LM 107
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 396-495 1.06e-09

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 55.84  E-value: 1.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356   396 ATALIMVITELVQNAIEHAfdPAAAEGSVTIRAErsaRWLDVVVHDDGLGLP--------QGFSLEKSDS-----LGLQI 462
Cdd:pfam02518   3 ELRLRQVLSNLLDNALKHA--AKAGEITVTLSEG---GELTLTVEDNGIGIPpedlprifEPFSTADKRGgggtgLGLSI 77

                          90       100       110
                  ....*....|....*....|....*....|...
gi 15610356   463 VRTLVSAeLDGSLGMRDARERGTDVVLRVPVGR 495
Cdd:pfam02518  78 VRKLVEL-LGGTITVESEPGGGTTVTLTLPLAQ 109
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 215-493 2.33e-09

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 59.04  E-value: 2.33e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 215 LIDATRPLISDPFEAHEVDEHVQDLLAGDGKGMRMEVDAGGATVLLRTLPLVVAGRNVGAAILIRDVTEVKRRDRALISK 294
Cdd:COG4191  50 LLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELREL 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 295 DATIRE-------------IHHRVKNNLQTVAA----LLRLQARRTSNAEGREAL---IESVRRVSSIalVHDALSMS-- 352
Cdd:COG4191 130 QEQLVQseklaalgelaagIAHEINNPLAAILGnaelLRRRLEDEPDPEELREALeriLEGAERAAEI--VRSLRAFSrr 207

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 353 ---VDEQVNLDEVIDRILPIMNDVASvDRPIRINRV--GDLGVLDSDRaTALIMVITELVQNAIeHAFdPAAAEGSVTIR 427
Cdd:COG4191 208 deeEREPVDLNELIDEALELLRPRLK-ARGIEVELDlpPDLPPVLGDP-GQLEQVLLNLLINAI-DAM-EEGEGGRITIS 283

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15610356 428 AERSARWLDVVVHDDGLGLPQG--------FSLEKSDS----LGLQIVRTLVSAeLDGSLGMRDARERGTDVVLRVPV 493
Cdd:COG4191 284 TRREGDYVVISVRDNGPGIPPEvlerifepFFTTKPVGkgtgLGLSISYGIVEK-HGGRIEVESEPGGGTTFTITLPL 360
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 179-500 2.35e-09

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 59.60  E-value: 2.35e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 179 DGFIRLDVDGVVSYASPnalSAYHRMGLT-TELEGVNLIDatrpLISdPFEAHEVDEHVQDLLAgDGKGMRMEVDAG--- 254
Cdd:COG5809 152 DGIIVTDLDGRIIYANP---AACKLLGISiEELIGKSILE----LIH-SDDQENVAAFISQLLK-DGGIAQGEVRFWtkd 222

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 255 GATVLL--RTLPLVVAGRNVGAAILIRDVTEVKRRDRALISKD--ATIRE----IHHRVKNNLQTVAALLRLqARRTSNA 326
Cdd:COG5809 223 GRWRLLeaSGAPIKKNGEVDGIVIIFRDITERKKLEELLRKSEklSVVGElaagIAHEIRNPLTSLKGFIQL-LKDTIDE 301

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 327 EGR---EALIESVRRVSSIalVHDALSMS----VD-EQVNLDEVIDRILPIMNDVA---SVDrpIRINRVGDLG--VLDS 393
Cdd:COG5809 302 EQKtylDIMLSELDRIESI--ISEFLVLAkpqaIKyEPKDLNTLIEEVIPLLQPQAllkNVQ--IELELEDDIPdiLGDE 377

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 394 DRataLIMVITELVQNAIEhafdpAAAE-GSVTIRAERSARwlDVV---VHDDGLGLPQG---------FSL-EKSDSLG 459
Cdd:COG5809 378 NQ---LKQVFINLLKNAIE-----AMPEgGNITIETKAEDD--DKVvisVTDEGCGIPEErlkklgepfYTTkEKGTGLG 447

                       330       340       350       360
                ....*....|....*....|....*....|....*....|.
gi 15610356 460 LQIVRTLVSaELDGSLGMRDARERGTDVVLRVPVGRRGRLM 500
Cdd:COG5809 448 LMVSYKIIE-EHGGKITVESEVGKGTTFSITLPIKLSEQVS 487
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
209-495 4.99e-09

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 58.03  E-value: 4.99e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 209 ELEGVNLIDATRPLISDPFEAHEVDEHVQDLLAGDGKGMRMEVDAGGATVLLRTLPLVVAGRNVGAAILIRDVTEVKRRD 288
Cdd:COG5002  83 LLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLE 162

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 289 RAlisKDATIREIHHRVKN---NLQTVAALLRLQARRTSNAEGR--EALIESVRRVSSiaLVHDALSMS---------VD 354
Cdd:COG5002 163 QM---RREFVANVSHELRTpltSIRGYLELLLDGAADDPEERREylEIILEEAERLSR--LVNDLLDLSrlesgelklEK 237

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 355 EQVNLDEVIDRILPIMNDVASvDRPIRINRVGDLGVL----DSDRataLIMVITELVQNAIEHAfdpaAAEGSVTIRAER 430
Cdd:COG5002 238 EPVDLAELLEEVVEELRPLAE-EKGIELELDLPEDPLlvlgDPDR---LEQVLTNLLDNAIKYT----PEGGTITVSLRE 309

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 431 SARWLDVVVHDDGLGLPQG---------FSLEKSDS-------LGLQIVRTLVSAeLDGSLGMRDARERGTDVVLRVPVG 494
Cdd:COG5002 310 EDDQVRISVRDTGIGIPEEdlpriferfYRVDKSRSretggtgLGLAIVKHIVEA-HGGRIWVESEPGKGTTFTITLPLA 388


                .
gi 15610356 495 R 495
Cdd:COG5002 389 R 389
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
406-493 2.25e-08

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 56.03  E-value: 2.25e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 406 LVQNAIEHAFDPAAAEGSVTIRAERSARWLDVVVHDDGLGLPQGfSLEKSDSLGLQIVR---TLVSAElDGSLGMRDARE 482
Cdd:COG3275 261 LVENAIKHGISSKEGGGTISISIEVEGDRLVIEVENNGVGIQPK-KKKKGSGIGLKNVRerlELLYGD-KYSLEIESTDG 338

                        90
                ....*....|.
gi 15610356 483 RGTDVVLRVPV 493
Cdd:COG3275 339 GGTKVTLKIPL 349
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
406-496 3.65e-08

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 55.79  E-value: 3.65e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 406 LVQNAIEHAFDPAAAEGSVTIRAERSARWLDVVVHDDGLGLPQgfslEKSDslglQIVRTLVSAELDGSLGMRDARER-- 483
Cdd:COG2972 344 LVENAIEHGIEPKEGGGTIRISIRKEGDRLVITVEDNGVGMPE----EKLE----KLLEELSSKGEGRGIGLRNVRERlk 415

                        90       100       110
                ....*....|....*....|....*....|
gi 15610356 484 -----------------GTDVVLRVPVGRR 496
Cdd:COG2972 416 lyygeeygleiesepgeGTTVTIRIPLEEE 445
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
179-495 7.71e-08

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 54.97  E-value: 7.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356  179 DGFIRLDVDGVVSYASPnalSAYHRMGLTT-ELEGVN---LIDATRPLISDPFEAHEVDEHVQDLLagdgkgMRMEVDAG 254
Cdd:PRK11360 273 DGVIAIDRQGKITTMNP---AAEVITGLQRhELVGKPyseLFPPNTPFASPLLDTLEHGTEHVDLE------ISFPGRDR 343

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356  255 GATVLLRTLPLVVAGRN-VGAAILIRDVTEVKRRDRALISKD--ATIRE----IHHRVKNNLQTVAALLRLQARRTSNAE 327
Cdd:PRK11360 344 TIELSVSTSLLHNTHGEmIGALVIFSDLTERKRLQRRVARQErlAALGElvagVAHEIRNPLTAIRGYVQIWRQQTSDPP 423

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356  328 GREALIESVRRVSSIALVHDAL------SMSVDEQVNLDEVIDRILPIMNDVASVDRpIRInrvgdlgVLDSDRATALIM 401
Cdd:PRK11360 424 SQEYLSVVLREVDRLNKVIDQLlefsrpRESQWQPVSLNALVEEVLQLFQTAGVQAR-VDF-------ETELDNELPPIW 495

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356  402 VITELV----QNAIEHAFDPAAAEGSVTIRAERSA-RWLDVVVHDDGLGLPQG---------FSLEKSDS-LGLQIVRTL 466
Cdd:PRK11360 496 ADPELLkqvlLNILINAVQAISARGKIRIRTWQYSdGQVAVSIEDNGCGIDPEllkkifdpfFTTKAKGTgLGLALSQRI 575

                        330       340
                 ....*....|....*....|....*....
gi 15610356  467 VSAElDGSLGMRDARERGTDVVLRVPVGR 495
Cdd:PRK11360 576 INAH-GGDIEVESEPGVGTTFTLYLPINP 603
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 402-493 2.09e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 46.33  E-value: 2.09e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 402 VITELVQNAIEhaFDPaaaEGSVTIRAERSAR-----WLDVVVHDDGLGLP--------QGFS-LEKSDS-------LGL 460
Cdd:cd16922   4 ILLNLLGNAIK--FTE---EGEVTLRVSLEEEeedgvQLRFSVEDTGIGIPeeqqarlfEPFSqADSSTTrkyggtgLGL 78

                        90       100       110
                ....*....|....*....|....*....|...
gi 15610356 461 QIVRTLVSAeLDGSLGMRDARERGTDVVLRVPV 493
Cdd:cd16922  79 AISKKLVEL-MGGDISVESEPGQGSTFTFTLPL 110
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 402-467 5.34e-06

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 44.57  E-value: 5.34e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15610356 402 VITELVQNAIEHAFdPAAAEGSVTIRAERSARWLDVVVHDDGLGLPQGFSLEKSDS-----LGLQIVRTLV 467
Cdd:cd16936   4 AVSEAVTNAVRHAY-RHDGPGPVRLELDLDPDRLRVEVTDSGPGFDPLRPADPDAGlreggRGLALIRALM 73
HWE_HK smart00911
HWE histidine kinase; The HWE domain is found in a subset of two-component system kinases, ...
 300-367 7.86e-06

HWE histidine kinase; The HWE domain is found in a subset of two-component system kinases, belonging to the same superfamily as. In. the HWE family was defined by the presence of conserved a H residue and a WXE motifs and was limited to members of the proteobacteria. However, many homologues of this domain are lack the WXE motif. Furthermore, homologues are found in a wide range of Gram-positive and Gram-negative bacteria as well as in several archaea.


Pssm-ID: 214907 [Multi-domain]  Cd Length: 84  Bit Score: 44.11  E-value: 7.86e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15610356    300 EIHHRVKNNLQTVAALLRLQARRTSNAEG-REALIEsvrRVSSIALVHDALSMSVDEQVNLDEVIDRIL 367
Cdd:smart00911   1 ELNHRVKNLLAVVQAIARQTLRSASSLEDfAEAFEG---RLQALARAHDLLSRSDWSGADLRDLVRAEL 66
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 402-492 1.47e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 43.97  E-value: 1.47e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 402 VITELVQNAIEHAFDPAAAEGSVTIRAERSARWLDVVVHDDGLGLPQ------GFSLEKSDSLGLQIVRTLVSAELDGSL 475
Cdd:cd16924   5 TLQPLVENAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNGRGIDPkvlnilGKKPKEGNGIGLYNVHQRLILLFGEDY 84

                        90
                ....*....|....*....
gi 15610356 476 GMR--DARERGTDVVLRVP 492
Cdd:cd16924  85 GIHiaSEPDKGTRITFTIP 103
HWE_HK pfam07536
HWE histidine kinase; Two-component systems, consisting of a histidine kinase and a cognate ...
 300-367 2.80e-05

HWE histidine kinase; Two-component systems, consisting of a histidine kinase and a cognate response regulator protein, represent the best-known apparatus for transducing external cues into a physiological response in bacteria. The HWE domain is found in a subset of two-component system kinases, belonging to the same superfamily as pfam00512 and pfam07568. The family was defined by the presence of a highly conserved H residue in the kinase domain and a WxE motif in a C-terminal ATPase domain that is related to pfam02518. It has been demonstrated to show structural and functional correlation with pfam07568. These proteins are found in a variety of alpha- and gamma- proteobacteria, with significant enrichment in the rhizobia.


Pssm-ID: 429521 [Multi-domain]  Cd Length: 83  Bit Score: 42.64  E-value: 2.80e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15610356   300 EIHHRVKNNLQTVAALLRLQARRTSN-AEGREALIEsvrRVSSIALVHDALSMSVDEQVNLDEVIDRIL 367
Cdd:pfam07536   1 ELNHRVKNTLATVQSIARQTLRNAASlDEFVEAFEG---RLQALSRAHDLLSRASWAGADLSELLEAEL 66
HATPase_YpdA-like cd16955
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 401-492 9.32e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340431 [Multi-domain]  Cd Length: 102  Bit Score: 41.68  E-value: 9.32e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 401 MVITELVQNAIEHAFDPAAAEGSVTIRA-ERSARWLDVVVHDDGLGLPQGF------SLEKSDSLGLQIVRTLVSAELDG 473
Cdd:cd16955   4 LMIQPLVENAIVHGIQEKKGKGVVKISVkKQLKNRLHIAVEDNGIGISPKVierveqDEMPGNKIGLLNVHQRLKLGYGE 83

                        90
                ....*....|....*....
gi 15610356 474 SLGMRDARERGTDVVLRVP 492
Cdd:cd16955  84 GLHIRSRPDPGTLIAFYIP 102
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 403-492 1.37e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 40.88  E-value: 1.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 403 ITELVQNAIEHAFDPAAAEGSVTIRAERSARWLDVVVHDDGLGL-PQGFSLEKSDS---LGLQIVRTLVSAELDGSLGM- 477
Cdd:cd16956   6 LQPIVENAVKHGLSGLLDGGRVEITARLDGQHLLLEVEDNGGGMdPDTLARILIRSsngLGLNLVDKRLRQAFGNDYGLd 85

                        90
                ....*....|....*.
gi 15610356 478 -RDARERGTDVVLRVP 492
Cdd:cd16956  86 iECAPGEGTRITIRLP 101
PRK13559 PRK13559
hypothetical protein; Provisional
 279-493 1.46e-04

hypothetical protein; Provisional


Pssm-ID: 237427 [Multi-domain]  Cd Length: 361  Bit Score: 44.04  E-value: 1.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356  279 RDVTEVKRRDRALISKDATIREIHHRVKNNLQTVAALLRLQARRTSNAEGREALIEsvrRVSSIALVHDA-LSMSVDEQV 357
Cdd:PRK13559 155 WDVTDIRAVRALEAHERRLAREVDHRSKNVFAVVDSIVRLTGRADDPSLYAAAIQE---RVQALARAHETlLDERGWETV 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356  358 NLDEVIDRIL-PIMND---VASVDRPIRinrvgdlgvLDSDRATALIMVITELVQNAIEH-AFDPAAAEGSVTIRAERSA 432
Cdd:PRK13559 232 EVEELIRAQVaPYAPRatrVAFEGPGIR---------LGAASVQPLGLVLHELAVNAIKHgALSADQGRISISWKPSPEG 302

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15610356  433 RWLDVVVHDDGLGLPQGfslEKSDSLGLQIVRTLVSAELDGSLgMRDARERGTDVVLRVPV 493
Cdd:PRK13559 303 AGFRIDWQEQGGPTPPK---LAKRGFGTVIIGAMVESQLNGQL-EKTWSDDGLLARIEIPS 359
HATPase_c_2 pfam13581
Histidine kinase-like ATPase domain;
391-467 2.44e-04

Histidine kinase-like ATPase domain;


Pssm-ID: 433327 [Multi-domain]  Cd Length: 127  Bit Score: 41.12  E-value: 2.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356   391 LDSDRATALIMVITELVQNAIEHAFdPAAAEGSVTIRAERSARWLDVVVHDDGLG----------LPQGFSLEKSDSLGL 460
Cdd:pfam13581  24 LPEELLDEVELAVGEACTNAVEHAY-REGPEGPVEVRLTSDGGGLVVTVADSGPPfdpltlpppdLEEPDEDRKEGGRGL 102


                  ....*..
gi 15610356   461 QIVRTLV 467
Cdd:pfam13581 103 ALIRGLM 109
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 402-469 3.06e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 40.07  E-value: 3.06e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15610356 402 VITELVQNAIEHAFDPAAAEGSVTIRAERSA-RWLDVVVHDDGLGLPQG--------FSLEKSDSL--GLQIVRTLVSA 469
Cdd:cd16920   4 VLINLVRNGIEAMSEGGCERRELTIRTSPADdRAVTISVKDTGPGIAEEvagqlfdpFYTTKSEGLgmGLSICRSIIEA 82
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 250-498 3.97e-04

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 42.98  E-value: 3.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356  250 EVDAGGATVLLRTLPLVVAGRNVGAAILIRDVTEVK----RRDRALISKDAtIREIHHRVKNNLQTVAALLRLQarrtsN 325
Cdd:PRK11086 292 EININGRLLLTNTVPVRVNGEIIGAIATFRDKTEVRqlaqRLDGMVNYADA-LRAQSHEFMNKLHVILGLLHLK-----S 365

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356  326 AEGREALIesvrrvssialvhdaLSMSVDEQvnldeviDRILPIMNDVASvdrPI-------RINRVGDLGVL------- 391
Cdd:PRK11086 366 YDQLEDYI---------------LKTANNYQ-------EEIGSLLGKIKS---PViagfllgKISRARELGITliiseds 420

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356  392 ------DSDRATALIMVITELVQNAIEHAFDpaAAEGSVTIRAERSARWLDVVVHDDGLGLP---------QGFSLEKSD 456
Cdd:PRK11086 421 qlpdsgDEDQVHELITILGNLIENALEAVGG--EEGGEISVSLHYRNGWLHCEVSDDGPGIApdeidaifdKGYSTKGSN 498

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 15610356  457 -SLGLQIVRTLVSAeLDGSLGMRDARERGTDVVLRVPVGRRGR 498
Cdd:PRK11086 499 rGVGLYLVKQSVEN-LGGSIAVESEPGVGTQFFVQIPWDGERS 540
PRK10490 PRK10490
sensor protein KdpD; Provisional
 359-467 4.22e-04

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 43.10  E-value: 4.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356  359 LDEVIDRILPIMNDVASvDRPIRINRVGDLGVLDSDrATALIMVITELVQNAIEHAFDPAaaegSVTIRAERSARWLDVV 438
Cdd:PRK10490 741 LEEVVGSALQMLEPGLS-GHPINLSLPEPLTLIHVD-GPLFERVLINLLENAVKYAGAQA----EIGIDAHVEGERLQLD 814

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 15610356  439 VHDDGLGLPQG--------FSLEKSDS------LGLQIVRTLV 467
Cdd:PRK10490 815 VWDNGPGIPPGqeqlifdkFARGNKESaipgvgLGLAICRAIV 857
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 399-492 7.05e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 38.69  E-value: 7.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 399 LIMVITELVQNAIEHAfdpAAAEGSVTIRaeRSARWLDVVVHDDGLGlPQGFSLEKSDSLGLQIVRTLVSAeLDGSLGMR 478
Cdd:cd16917   1 LYRIVQEALTNALKHA---GASRVRVTLS--YTADELTLTVVDDGVG-FDGPAPPGGGGFGLLGMRERAEL-LGGTLTIG 73

                        90
                ....*....|....
gi 15610356 479 DARERGTDVVLRVP 492
Cdd:cd16917  74 SRPGGGTRVTARLP 87
PAS COG2202
PAS domain [Signal transduction mechanisms];
177-291 1.05e-03

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 40.78  E-value: 1.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 177 AGDGFIRLDVDGVVSYASPNALSAYhrmGLT-TELEGVNLIDatrplISDPFEAHEVDEHVQDLLAGDGKGMRMEV---D 252
Cdd:COG2202 146 APDGIFVLDLDGRILYVNPAAEELL---GYSpEELLGKSLLD-----LLHPEDRERLLELLRRLLEGGRESYELELrlkD 217

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 15610356 253 AGGATVLLRT--LPLVVAGRNVGAAILIRDVTEVKRRDRAL 291
Cdd:COG2202 218 GDGRWVWVEAsaVPLRDGGEVIGVLGIVRDITERKRAEEAL 258
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 399-492 1.21e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 38.42  E-value: 1.21e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 399 LIMVITELVQNAIEHAFDPAAAEGSVTIRAERSARWLDVVVHDDGLGLP---------QGFSL--EKSDSLGLQIVRTLV 467
Cdd:cd16915   1 LITIVGNLIDNALDALAATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIApelrdkvfeRGVSTkgQGERGIGLALVRQSV 80

                        90       100
                ....*....|....*....|....*
gi 15610356 468 SaELDGSLGMRDARERGTDVVLRVP 492
Cdd:cd16915  81 E-RLGGSITVESEPGGGTTFSIRIP 104
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 399-495 1.44e-03

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 40.98  E-value: 1.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356  399 LIMVITELVQNAIEhaFDPAaaEGSVTIRAERSARWLDVVVHDDGLGLP---------QGFSL------EKSDSLGLQIV 463
Cdd:PRK11100 369 LRQALGNLLDNAID--FSPE--GGTITLSAEVDGEQVALSVEDQGPGIPdyalprifeRFYSLprpangRKSTGLGLAFV 444

                         90       100       110
                 ....*....|....*....|....*....|..
gi 15610356  464 RTlVSAELDGSLGMRDARERGTDVVLRVPVGR 495
Cdd:PRK11100 445 RE-VARLHGGEVTLRNRPEGGVLATLTLPRHF 475
UhpB COG3851
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction ...
 283-496 1.84e-03

Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction mechanisms];


Pssm-ID: 443060 [Multi-domain]  Cd Length: 493  Bit Score: 40.76  E-value: 1.84e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 283 EVKRRDRAliskdatiREIHHRVKNNLQTVaallRLQARRTSNAEGREALIESVRRVSSIALV-----HDALSM---SVD 354
Cdd:COG3851 290 ESERREIA--------RELHDEIGQNITAI----RTQASILKRLAPQPEIEQSAQSIESLALRiydttRRLLDRlrpAVL 357

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 355 EQVNLDEVIdRILPI--MNDVASVDRPIRINrvGDLGVLDSDRATALIMVITELVQNAIEHAFdpaaaEGSVTIRAERSA 432
Cdd:COG3851 358 DELGLEEAL-RELPRelAFEEPGISCQLDLR--GDPSLLDDTLQLTLYRLVQEALTNILKHAE-----ASQIRISLSQDK 429

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15610356 433 RWLDVVVHDDGLGLPqgfSLEKSDSLGLQIVRTLVSAeLDGSLGMRDAReRGTDVVLRVPVGRR 496
Cdd:COG3851 430 RLLSLEIRDDGIGLP---PELRAKGFGLRGMRERVRA-LGGDFRLSSAP-KGTRLSVLLPTPAA 488
sensory_box TIGR00229
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...
 177-291 2.05e-03

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]


Pssm-ID: 272971 [Multi-domain]  Cd Length: 124  Bit Score: 38.04  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356   177 AGDGFIRLDVDGVVSYASPnalsAYHRM-GLT-TELEGVNLIDatrpLISDPFEAhEVDEHVQDLLAGDGKGMRMEV--- 251
Cdd:TIGR00229  12 SPDAIIVIDLEGNILYVNP----AFEEIfGYSaEELIGRNVLE----LIPEEDRE-EVRERIERRLEGEPEPVSEERrvr 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 15610356   252 --DAGGATVLLRTLPLVVAGRNVGAAILIRDVTEVKRRDRAL 291
Cdd:TIGR00229  83 rkDGSEIWVEVSVSPIRTNGGELGVVGIVRDITERKEAEEAL 124
RocR COG3829
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...
 177-291 4.34e-03

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];


Pssm-ID: 443041 [Multi-domain]  Cd Length: 448  Bit Score: 39.37  E-value: 4.34e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 177 AGDGFIRLDVDGVVSYASPNAlsayhrmgltTELEGVNLIDATRPLISDPFEAHEVDEHVQDllagdGK---GMRMEVDA 253
Cdd:COG3829  20 LDDGIIVVDADGRITYVNRAA----------ERILGLPREEVIGKNVTELIPNSPLLEVLKT-----GKpvtGVIQKTGG 84

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15610356 254 GGATVLLRTLPLVVAGRNVGAAILIRDVTEVKRRDRAL 291
Cdd:COG3829  85 KGKTVIVTAIPIFEDGEVIGAVETFRDITELKRLERKL 122
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 396-492 6.53e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 36.36  E-value: 6.53e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610356 396 ATALIMVITELVQNAIEHAFDPAAAEGSVTIRAERSARW-LDVVVHDDGLGLPQGF----------SLEKSDSLGLQIVR 464
Cdd:cd16944   2 TTQISQVLTNILKNAAEAIEGRPSDVGEVRIRVEADQDGrIVLIVCDNGKGFPREMrhratepyvtTRPKGTGLGLAIVK 81

                        90       100
                ....*....|....*....|....*...
gi 15610356 465 TLVSaELDGSLGMRDARERGTDVVLRVP 492
Cdd:cd16944  82 KIME-EHGGRISLSNREAGGACIRIILP 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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