NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|15595789|ref|NP_249283|]
View 

ribosomal RNA small subunit methyltransferase A [Pseudomonas aeruginosa PAO1]

Protein Classification

ribosomal RNA small subunit methyltransferase A( domain architecture ID 10000482)

ribosomal RNA small subunit methyltransferase A specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle

CATH:  2.20.25.110
EC:  2.1.1.-|2.1.1.182
Gene Ontology:  GO:1904047|GO:0052908|GO:0031167
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 1-263 3.18e-144

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


:

Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 404.89  E-value: 3.18e-144
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789   1 MSELYQHRARKRFGQNFLHDAGVIHRILRAIHAREGQRLLEIGPGQGALTEGLLGSGARLDVIELDQDLIPLLKLKFGLE 80
Cdd:COG0030   3 KSRRYGLRPKKRLGQNFLIDPNIIRRIVDAAGITPGDTVLEIGPGLGALTRALLERAARVTAVEIDRRLAAILRETFAAY 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789  81 SRFSLHQGDALKFDFASLVEsGEKLRVVGNLPYNISTPLIFHLLEHAPVIEDMHFMLQKEVVERLAATPGGGDWGRLSIM 160
Cdd:COG0030  83 PNLTVIEGDALKVDLPALAA-GEPLKVVGNLPYNISTPILFKLLEARPPIEDAVLMVQKEVAERLVAKPGSKDYGRLSVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789 161 VQYHCRVEHLFNVGPGAFNPPPKVDSAIVRLTPFAEPPHPARDPKLLERVVREAFNQRRKTLRNTLKPLLS----VEDIE 236
Cdd:COG0030 162 VQYYADVEILFTVPPEAFYPPPKVDSAVVRLTPRPEPLVPVADEKLFFRVVKAAFSQRRKTLRNSLKSLFSkerlEEALE 241

                       250       260
                ....*....|....*....|....*..
gi 15595789 237 AAEVDPTLRPEQLDLAAFVRLANQLAE 263
Cdd:COG0030 242 AAGIDPTARAEELSVEEFARLANALKK 268
 
Name Accession Description Interval E-value
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 1-263 3.18e-144

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 404.89  E-value: 3.18e-144
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789   1 MSELYQHRARKRFGQNFLHDAGVIHRILRAIHAREGQRLLEIGPGQGALTEGLLGSGARLDVIELDQDLIPLLKLKFGLE 80
Cdd:COG0030   3 KSRRYGLRPKKRLGQNFLIDPNIIRRIVDAAGITPGDTVLEIGPGLGALTRALLERAARVTAVEIDRRLAAILRETFAAY 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789  81 SRFSLHQGDALKFDFASLVEsGEKLRVVGNLPYNISTPLIFHLLEHAPVIEDMHFMLQKEVVERLAATPGGGDWGRLSIM 160
Cdd:COG0030  83 PNLTVIEGDALKVDLPALAA-GEPLKVVGNLPYNISTPILFKLLEARPPIEDAVLMVQKEVAERLVAKPGSKDYGRLSVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789 161 VQYHCRVEHLFNVGPGAFNPPPKVDSAIVRLTPFAEPPHPARDPKLLERVVREAFNQRRKTLRNTLKPLLS----VEDIE 236
Cdd:COG0030 162 VQYYADVEILFTVPPEAFYPPPKVDSAVVRLTPRPEPLVPVADEKLFFRVVKAAFSQRRKTLRNSLKSLFSkerlEEALE 241

                       250       260
                ....*....|....*....|....*..
gi 15595789 237 AAEVDPTLRPEQLDLAAFVRLANQLAE 263
Cdd:COG0030 242 AAGIDPTARAEELSVEEFARLANALKK 268
ksgA TIGR00755
ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, ...
 7-261 4.35e-111

ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, this protein is responsible for the dimethylation of two adjacent adenosine residues in a conserved hairpin of 16S rRNA in bacteria, 18S rRNA in eukaryotes. This adjacent dimethylation is the only rRNA modification shared by bacteria and eukaryotes. A single member of this family is present in each of the first 20 completed microbial genomes. This protein is essential in yeast, but not in E. coli, where its deletion leads to resistance to the antibiotic kasugamycin. Alternate name: S-adenosylmethionine--6-N',N'-adenosyl (rRNA) dimethyltransferase [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273252 [Multi-domain]  Cd Length: 254  Bit Score: 320.33  E-value: 4.35e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789     7 HRARKRFGQNFLHDAGVIHRILRAIHAREGQRLLEIGPGQGALTEGLLGSGARLDVIELDQDLIPLLKLKFGLESRFSLH 86
Cdd:TIGR00755   1 FRPRKSLGQNFLVDENVIRKIVEAANIQEGDRVLEIGPGLGALTEPLLKRAKKVTAIEIDPRLAERLRKLLSLYNNLEII 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789    87 QGDALKFDFASLveSGEKLRVVGNLPYNISTPLIFHLLEHAPVIEDMHFMLQKEVVERLAATPGGGDWGRLSIMVQYHCR 166
Cdd:TIGR00755  81 EGDALKFDLNEL--AKDLTKVVGNLPYNISSPLIFKLLKEKDAFKLAVLMVQKEVAERLVAKPGSKDYGRLSVLVQYYAN 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789   167 VEHLFNVGPGAFNPPPKVDSAIVRLTPFAEPPHPArDPKLLERVVREAFNQRRKTLRNTLKPLLS--VEDIEAAEVDPTL 244
Cdd:TIGR00755 159 VEIVFKVPPSAFYPPPKVDSAVVRLVPLKRKPSPK-DFALFEELLKAAFQQRRKTLRNNLKNLLSelVELLEELGIDPDK 237

                         250
                  ....*....|....*..
gi 15595789   245 RPEQLDLAAFVRLANQL 261
Cdd:TIGR00755 238 RVEQLSPEDFLRLANLL 254
rADc smart00650
Ribosomal RNA adenine dimethylases;
23-193 2.63e-80

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 239.33  E-value: 2.63e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789     23 VIHRILRAIHAREGQRLLEIGPGQGALTEGLLGSGARLDVIELDQDLIPLLKLKFGLESRFSLHQGDALKFDFASLvesg 102
Cdd:smart00650   1 VIDKIVRAANLRPGDTVLEIGPGKGALTEELLERAKRVTAIEIDPRLAPRLREKFAAADNLTVIHGDALKFDLPKL---- 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789    103 EKLRVVGNLPYNISTPLIFHLLEHAPVIEDMHFMLQKEVVERLAATPGGGDWGRLSIMVQYHCRVEHLFNVGPGAFNPPP 182
Cdd:smart00650  77 QPYKVVGNLPYNISTPILFKLLEEPPAFRDAVLMVQKEVARRLAAKPGSKDYGRLSVLLQPYADVKILFKVPPSAFRPPP 156

                          170
                   ....*....|.
gi 15595789    183 KVDSAIVRLTP 193
Cdd:smart00650 157 KVDSAVVRLER 167
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
7-263 1.40e-79

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 240.73  E-value: 1.40e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789     7 HRARKRFGQNFLHDAGVIHRILRAIHAREGQRLLEIGPGQGALTEGLLGSGARLDVIELDQDLIPLLKLKFGLESRFSLH 86
Cdd:pfam00398   2 NKFRTSYGQNFLKDPKVINEIVDKANLRESDTVLEIGPGKGALTVILAKRAKQVVAIEIDPRLAKLLQKKLSLDENLTVI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789    87 QGDALKFDFASLVES-GEKLRVVGNLPYNISTPLIFHLL-EHAPVIEDMHFMLQKEVVERLAATPGGGDWGRLSIMVQYH 164
Cdd:pfam00398  82 HQDFLKFEFPSLVTHiHQEFLVVGNLPYNISTPIVKQLLfESRFGIVDMLLMLQKEFARRLLARPGSKLYSRLSVLRQAF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789   165 CRVEHLFNVGPGAFNPPPKVDSAIVRLTPFAEPPHPARDPKLLERVVREAFNQRRKTLRNTLKPLLSVEDIEAAE---VD 241
Cdd:pfam00398 162 TDVKLVAKVPPSIFSPPPKVDSALVRLERHDPDPHPVKDLDVYDSVVRKLFNRKRKTLSTSLKSLFPGGQLQAFSshgIN 241

                         250       260
                  ....*....|....*....|..
gi 15595789   242 PTLRPEQLDLAAFVRLANQLAE 263
Cdd:pfam00398 242 DNALVKKLSPEQTLDIFNELAK 263
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
7-264 6.90e-77

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 233.64  E-value: 6.90e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789    7 HRARKRFGQNFLHDAGVIHRILRAIHAREGQRLLEIGPGQGALTEGLLGSGARLDVIELDQDLIPLLKLKFGLESRFSLH 86
Cdd:PRK14896   1 IRMNKKLGQHFLIDDRVVDRIVEYAEDTDGDPVLEIGPGKGALTDELAKRAKKVYAIELDPRLAEFLRDDEIAAGNVEII 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789   87 QGDALKFDFASLvesgEKlrVVGNLPYNISTPLIFHLLEHApvIEDMHFMLQKEVVERLAATPGGGDWGRLSIMVQYHCR 166
Cdd:PRK14896  81 EGDALKVDLPEF----NK--VVSNLPYQISSPITFKLLKHG--FEPAVLMYQKEFAERMVAKPGTKEYGRLSVMVQYYAD 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789  167 VEHLFNVGPGAFNPPPKVDSAIVRLTPfAEPPHPARDPKLLERVVREAFNQRRKTLRNTLK---PLLSVEDIEA---AEV 240
Cdd:PRK14896 153 VEIVEKVPPGAFSPKPKVDSAVVRLTP-REPKYEVYDEDFFDDFVKALFQHRRKTLRNALKnsaHISGKEDIKAvveALP 231

                        250       260
                 ....*....|....*....|....*.
gi 15595789  241 DPTL--RPEQLDLAAFVRLANQLAEL 264
Cdd:PRK14896 232 EELLnkRVFQLSPEEIAELANLLYEV 257
 
Name Accession Description Interval E-value
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 1-263 3.18e-144

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 404.89  E-value: 3.18e-144
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789   1 MSELYQHRARKRFGQNFLHDAGVIHRILRAIHAREGQRLLEIGPGQGALTEGLLGSGARLDVIELDQDLIPLLKLKFGLE 80
Cdd:COG0030   3 KSRRYGLRPKKRLGQNFLIDPNIIRRIVDAAGITPGDTVLEIGPGLGALTRALLERAARVTAVEIDRRLAAILRETFAAY 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789  81 SRFSLHQGDALKFDFASLVEsGEKLRVVGNLPYNISTPLIFHLLEHAPVIEDMHFMLQKEVVERLAATPGGGDWGRLSIM 160
Cdd:COG0030  83 PNLTVIEGDALKVDLPALAA-GEPLKVVGNLPYNISTPILFKLLEARPPIEDAVLMVQKEVAERLVAKPGSKDYGRLSVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789 161 VQYHCRVEHLFNVGPGAFNPPPKVDSAIVRLTPFAEPPHPARDPKLLERVVREAFNQRRKTLRNTLKPLLS----VEDIE 236
Cdd:COG0030 162 VQYYADVEILFTVPPEAFYPPPKVDSAVVRLTPRPEPLVPVADEKLFFRVVKAAFSQRRKTLRNSLKSLFSkerlEEALE 241

                       250       260
                ....*....|....*....|....*..
gi 15595789 237 AAEVDPTLRPEQLDLAAFVRLANQLAE 263
Cdd:COG0030 242 AAGIDPTARAEELSVEEFARLANALKK 268
ksgA TIGR00755
ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, ...
 7-261 4.35e-111

ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, this protein is responsible for the dimethylation of two adjacent adenosine residues in a conserved hairpin of 16S rRNA in bacteria, 18S rRNA in eukaryotes. This adjacent dimethylation is the only rRNA modification shared by bacteria and eukaryotes. A single member of this family is present in each of the first 20 completed microbial genomes. This protein is essential in yeast, but not in E. coli, where its deletion leads to resistance to the antibiotic kasugamycin. Alternate name: S-adenosylmethionine--6-N',N'-adenosyl (rRNA) dimethyltransferase [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273252 [Multi-domain]  Cd Length: 254  Bit Score: 320.33  E-value: 4.35e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789     7 HRARKRFGQNFLHDAGVIHRILRAIHAREGQRLLEIGPGQGALTEGLLGSGARLDVIELDQDLIPLLKLKFGLESRFSLH 86
Cdd:TIGR00755   1 FRPRKSLGQNFLVDENVIRKIVEAANIQEGDRVLEIGPGLGALTEPLLKRAKKVTAIEIDPRLAERLRKLLSLYNNLEII 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789    87 QGDALKFDFASLveSGEKLRVVGNLPYNISTPLIFHLLEHAPVIEDMHFMLQKEVVERLAATPGGGDWGRLSIMVQYHCR 166
Cdd:TIGR00755  81 EGDALKFDLNEL--AKDLTKVVGNLPYNISSPLIFKLLKEKDAFKLAVLMVQKEVAERLVAKPGSKDYGRLSVLVQYYAN 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789   167 VEHLFNVGPGAFNPPPKVDSAIVRLTPFAEPPHPArDPKLLERVVREAFNQRRKTLRNTLKPLLS--VEDIEAAEVDPTL 244
Cdd:TIGR00755 159 VEIVFKVPPSAFYPPPKVDSAVVRLVPLKRKPSPK-DFALFEELLKAAFQQRRKTLRNNLKNLLSelVELLEELGIDPDK 237

                         250
                  ....*....|....*..
gi 15595789   245 RPEQLDLAAFVRLANQL 261
Cdd:TIGR00755 238 RVEQLSPEDFLRLANLL 254
rADc smart00650
Ribosomal RNA adenine dimethylases;
23-193 2.63e-80

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 239.33  E-value: 2.63e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789     23 VIHRILRAIHAREGQRLLEIGPGQGALTEGLLGSGARLDVIELDQDLIPLLKLKFGLESRFSLHQGDALKFDFASLvesg 102
Cdd:smart00650   1 VIDKIVRAANLRPGDTVLEIGPGKGALTEELLERAKRVTAIEIDPRLAPRLREKFAAADNLTVIHGDALKFDLPKL---- 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789    103 EKLRVVGNLPYNISTPLIFHLLEHAPVIEDMHFMLQKEVVERLAATPGGGDWGRLSIMVQYHCRVEHLFNVGPGAFNPPP 182
Cdd:smart00650  77 QPYKVVGNLPYNISTPILFKLLEEPPAFRDAVLMVQKEVARRLAAKPGSKDYGRLSVLLQPYADVKILFKVPPSAFRPPP 156

                          170
                   ....*....|.
gi 15595789    183 KVDSAIVRLTP 193
Cdd:smart00650 157 KVDSAVVRLER 167
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
7-263 1.40e-79

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 240.73  E-value: 1.40e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789     7 HRARKRFGQNFLHDAGVIHRILRAIHAREGQRLLEIGPGQGALTEGLLGSGARLDVIELDQDLIPLLKLKFGLESRFSLH 86
Cdd:pfam00398   2 NKFRTSYGQNFLKDPKVINEIVDKANLRESDTVLEIGPGKGALTVILAKRAKQVVAIEIDPRLAKLLQKKLSLDENLTVI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789    87 QGDALKFDFASLVES-GEKLRVVGNLPYNISTPLIFHLL-EHAPVIEDMHFMLQKEVVERLAATPGGGDWGRLSIMVQYH 164
Cdd:pfam00398  82 HQDFLKFEFPSLVTHiHQEFLVVGNLPYNISTPIVKQLLfESRFGIVDMLLMLQKEFARRLLARPGSKLYSRLSVLRQAF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789   165 CRVEHLFNVGPGAFNPPPKVDSAIVRLTPFAEPPHPARDPKLLERVVREAFNQRRKTLRNTLKPLLSVEDIEAAE---VD 241
Cdd:pfam00398 162 TDVKLVAKVPPSIFSPPPKVDSALVRLERHDPDPHPVKDLDVYDSVVRKLFNRKRKTLSTSLKSLFPGGQLQAFSshgIN 241

                         250       260
                  ....*....|....*....|..
gi 15595789   242 PTLRPEQLDLAAFVRLANQLAE 263
Cdd:pfam00398 242 DNALVKKLSPEQTLDIFNELAK 263
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
7-264 6.90e-77

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 233.64  E-value: 6.90e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789    7 HRARKRFGQNFLHDAGVIHRILRAIHAREGQRLLEIGPGQGALTEGLLGSGARLDVIELDQDLIPLLKLKFGLESRFSLH 86
Cdd:PRK14896   1 IRMNKKLGQHFLIDDRVVDRIVEYAEDTDGDPVLEIGPGKGALTDELAKRAKKVYAIELDPRLAEFLRDDEIAAGNVEII 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789   87 QGDALKFDFASLvesgEKlrVVGNLPYNISTPLIFHLLEHApvIEDMHFMLQKEVVERLAATPGGGDWGRLSIMVQYHCR 166
Cdd:PRK14896  81 EGDALKVDLPEF----NK--VVSNLPYQISSPITFKLLKHG--FEPAVLMYQKEFAERMVAKPGTKEYGRLSVMVQYYAD 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789  167 VEHLFNVGPGAFNPPPKVDSAIVRLTPfAEPPHPARDPKLLERVVREAFNQRRKTLRNTLK---PLLSVEDIEA---AEV 240
Cdd:PRK14896 153 VEIVEKVPPGAFSPKPKVDSAVVRLTP-REPKYEVYDEDFFDDFVKALFQHRRKTLRNALKnsaHISGKEDIKAvveALP 231

                        250       260
                 ....*....|....*....|....*.
gi 15595789  241 DPTL--RPEQLDLAAFVRLANQLAEL 264
Cdd:PRK14896 232 EELLnkRVFQLSPEEIAELANLLYEV 257
PTZ00338 PTZ00338
dimethyladenosine transferase-like protein; Provisional
 11-227 4.98e-51

dimethyladenosine transferase-like protein; Provisional


Pssm-ID: 240367 [Multi-domain]  Cd Length: 294  Bit Score: 168.64  E-value: 4.98e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789   11 KRFGQNFLHDAGVIHRILRAIHAREGQRLLEIGPGQGALTEGLLGSGARLDVIELDQDLIPLLKLKF---GLESRFSLHQ 87
Cdd:PTZ00338  12 KKFGQHILKNPLVLDKIVEKAAIKPTDTVLEIGPGTGNLTEKLLQLAKKVIAIEIDPRMVAELKKRFqnsPLASKLEVIE 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789   88 GDALKFDFAslvesgeKLRV-VGNLPYNISTPLIFHLLEHAPVIEDMHFMLQKEVVERLAATPGGGDWGRLSIMVQYHCR 166
Cdd:PTZ00338  92 GDALKTEFP-------YFDVcVANVPYQISSPLVFKLLAHRPLFRCAVLMFQKEFALRLLAQPGDELYCRLSVNTQLLCR 164

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15595789  167 VEHLFNVGPGAFNPPPKVDSAIVRLtpfaEPPHPARDPKLLE--RVVREAFNQRRKTLRNTLK 227
Cdd:PTZ00338 165 VTHLMKVSKNSFNPPPKVESSVVRI----EPKNPPPDVDFEEwdGLLRICFSRKNKTLSAIFK 223
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 24-151 2.54e-06

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 45.78  E-value: 2.54e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789  24 IHRILRAiHAREGQRLLEIGPGQGALTEGLLGSGARLDVIELDQDLIPLLKLKFGlESRFSLHQGDALKFDFAslvesGE 103
Cdd:COG2227  14 LAALLAR-LLPAGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAA-ELNVDFVQGDLEDLPLE-----DG 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 15595789 104 KLRVVgnlpynistpLIFHLLEHapvIEDMHFMLQkEVVERLAatPGG 151
Cdd:COG2227  87 SFDLV----------ICSEVLEH---LPDPAALLR-ELARLLK--PGG 118
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 25-96 5.57e-06

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 44.98  E-value: 5.57e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15595789  25 HRILRAIHAREGQRLLEIGPGQGALTEGLLGSGARLDVIELDQDLIPLLKLKFG-LESRFSLHQGDALKFDFA 96
Cdd:COG2226  12 EALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAeAGLNVEFVVGDAEDLPFP 84
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 20-90 1.13e-03

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 39.37  E-value: 1.13e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15595789  20 DAGVIhrILRA-IhaREGQRLLEIGPGQGALTEGLL---GSGARLDVIELDQDLIPLLK---LKFGLESRFSLHQGDA 90
Cdd:COG2519  79 DAGYI--IARLdI--FPGARVLEAGTGSGALTLALAravGPEGKVYSYERREDFAEIARknlERFGLPDNVELKLGDI 152
PRK08317 PRK08317
hypothetical protein; Provisional
 25-96 1.40e-03

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 39.15  E-value: 1.40e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15595789   25 HRILRAIHAREGQRLLEIGPGQGALT---EGLLGSGARLDVIELDQDLIPLLKL-KFGLESRFSLHQGDALKFDFA 96
Cdd:PRK08317   9 ARTFELLAVQPGDRVLDVGCGPGNDArelARRVGPEGRVVGIDRSEAMLALAKErAAGLGPNVEFVRGDADGLPFP 84
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 40-97 4.85e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 35.72  E-value: 4.85e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 15595789    40 LEIGPGQGALTEGLLGSGARLDVIELDQDLIPLLKLKFGlESRFSLHQGDALKFDFAS 97
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAP-REGLTFVVGDAEDLPFPD 57
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 24-103 5.79e-03

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 36.45  E-value: 5.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595789  24 IHRILRAIHAREGQRLLEIGPGQGALTEGLLGS-GARLDVIELDQDLIPLLK---LKFGLESRFSLHQGDAL------KF 93
Cdd:COG2230  40 LDLILRKLGLKPGMRVLDIGCGWGGLALYLARRyGVRVTGVTLSPEQLEYAReraAEAGLADRVEVRLADYRdlpadgQF 119

                        90
                ....*....|
gi 15595789  94 DFASLVESGE 103
Cdd:COG2230 120 DAIVSIGMFE 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH