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Conserved domains on  [gi|15596358|ref|NP_249852|]
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rRNA methyltransferase [Pseudomonas aeruginosa PAO1]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 3-252 1.79e-85

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member PRK11088:

Pssm-ID: 473071 [Multi-domain]  Cd Length: 272  Bit Score: 255.99  E-value: 1.79e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358    3 ICPLCSAALGEVDNGVACPAGHRFDRARQGYLNLLPVQHKKSLDPGDNAAMVEARRQFLGAGHYAPLARRLAELAAER-- 80
Cdd:PRK11088   4 QCPLCHQPLTLEENSWICPQNHQFDCAKEGYVNLLPVQHKRSKDPGDNKEMMQARRAFLDAGHYQPLRDAVANLLAERld 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358   81 -APRRWLDIGCGEGYYSARLGEALAG---AEGYALDISREAVKRACRRAPQLSWLVASMARLPLADASCELIASVFSPID 156
Cdd:PRK11088  84 eKATALLDIGCGEGYYTHALADALPEittMQLFGLDISKVAIKYAAKRYPQVTFCVASSHRLPFADQSLDAIIRIYAPCK 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358  157 WNEAVRILSPGGGVLRLGPASAHLLELRQRLYDDVRDYAD-DKHLAGlpaqLRLRHTETLEFRLALDSYDAReNLLAMTP 235
Cdd:PRK11088 164 AEELARVVKPGGIVITVTPGPRHLFELKGLIYDEVRLHAPeAEQLEG----FELQHSERLAYPMRLTGSEAV-ALLQMTP 238

                        250
                 ....*....|....*..
gi 15596358  236 HGWRVNPERRARILAEP 252
Cdd:PRK11088 239 FAWKATPEVKQQLAAKG 255
 
Name Accession Description Interval E-value
rrmA PRK11088
23S rRNA methyltransferase A; Provisional
 3-252 1.79e-85

23S rRNA methyltransferase A; Provisional


Pssm-ID: 236841 [Multi-domain]  Cd Length: 272  Bit Score: 255.99  E-value: 1.79e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358    3 ICPLCSAALGEVDNGVACPAGHRFDRARQGYLNLLPVQHKKSLDPGDNAAMVEARRQFLGAGHYAPLARRLAELAAER-- 80
Cdd:PRK11088   4 QCPLCHQPLTLEENSWICPQNHQFDCAKEGYVNLLPVQHKRSKDPGDNKEMMQARRAFLDAGHYQPLRDAVANLLAERld 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358   81 -APRRWLDIGCGEGYYSARLGEALAG---AEGYALDISREAVKRACRRAPQLSWLVASMARLPLADASCELIASVFSPID 156
Cdd:PRK11088  84 eKATALLDIGCGEGYYTHALADALPEittMQLFGLDISKVAIKYAAKRYPQVTFCVASSHRLPFADQSLDAIIRIYAPCK 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358  157 WNEAVRILSPGGGVLRLGPASAHLLELRQRLYDDVRDYAD-DKHLAGlpaqLRLRHTETLEFRLALDSYDAReNLLAMTP 235
Cdd:PRK11088 164 AEELARVVKPGGIVITVTPGPRHLFELKGLIYDEVRLHAPeAEQLEG----FELQHSERLAYPMRLTGSEAV-ALLQMTP 238

                        250
                 ....*....|....*..
gi 15596358  236 HGWRVNPERRARILAEP 252
Cdd:PRK11088 239 FAWKATPEVKQQLAAKG 255
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 63-187 1.78e-17

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 76.96  E-value: 1.78e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358  63 AGHYApLARRLAELAAERAPRRWLDIGCGEGYYSARLGEalAGAEGYALDISREAVKRACRRAP----QLSWLVASMARL 138
Cdd:COG2226   5 AARYD-GREALLAALGLRPGARVLDLGCGTGRLALALAE--RGARVTGVDISPEMLELARERAAeaglNVEFVVGDAEDL 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15596358 139 PLADASCELIASVFSPIDW-------NEAVRILSPGGGVLRLGPASAHLLELRQRL 187
Cdd:COG2226  82 PFPDGSFDLVISSFVLHHLpdperalAEIARVLKPGGRLVVVDFSPPDLAELEELL 137
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 86-168 9.05e-14

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 65.28  E-value: 9.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358    86 LDIGCGEGYYSARLGEALaGAEGYALDISREAVKRACRRA----PQLSWLVASMARLPLADASCELIASV-----FSPID 156
Cdd:pfam13649   2 LDLGCGTGRLTLALARRG-GARVTGVDLSPEMLERARERAaeagLNVEFVQGDAEDLPFPDGSFDLVVSSgvlhhLPDPD 80

                          90
                  ....*....|....*.
gi 15596358   157 W----NEAVRILSPGG 168
Cdd:pfam13649  81 LeaalREIARVLKPGG 96
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 82-185 6.28e-12

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 63.46  E-value: 6.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358    82 PRRWLDIGCGEGYYSARLGEALAGAEGYALDISREAVKRACRR-APQLSWLVASMARLPLADASCELIASVfSPIDW--- 157
Cdd:TIGR02072  35 PASVLDIGCGTGYLTRALLKRFPQAEFIALDISAGMLAQAKTKlSENVQFICGDAEKLPLEDSSFDLIVSN-LALQWcdd 113

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 15596358   158 -----NEAVRILSPGGGVL--RLGPASAHllELRQ 185
Cdd:TIGR02072 114 lsqalSELARVLKPGGLLAfsTFGPGTLH--ELRQ 146
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 84-168 1.30e-05

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 43.19  E-value: 1.30e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358  84 RWLDIGCGEGYYSARLGEALaGAEGYALDISREAVKRA-----CRRAPQLSWLVASMARLPL-ADASCELIASVFSPIDW 157
Cdd:cd02440   1 RVLDLGCGTGALALALASGP-GARVTGVDISPVALELArkaaaALLADNVEVLKGDAEELPPeADESFDVIISDPPLHHL 79

                        90
                ....*....|....*....
gi 15596358 158 --------NEAVRILSPGG 168
Cdd:cd02440  80 vedlarflEEARRLLKPGG 98
 
Name Accession Description Interval E-value
rrmA PRK11088
23S rRNA methyltransferase A; Provisional
 3-252 1.79e-85

23S rRNA methyltransferase A; Provisional


Pssm-ID: 236841 [Multi-domain]  Cd Length: 272  Bit Score: 255.99  E-value: 1.79e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358    3 ICPLCSAALGEVDNGVACPAGHRFDRARQGYLNLLPVQHKKSLDPGDNAAMVEARRQFLGAGHYAPLARRLAELAAER-- 80
Cdd:PRK11088   4 QCPLCHQPLTLEENSWICPQNHQFDCAKEGYVNLLPVQHKRSKDPGDNKEMMQARRAFLDAGHYQPLRDAVANLLAERld 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358   81 -APRRWLDIGCGEGYYSARLGEALAG---AEGYALDISREAVKRACRRAPQLSWLVASMARLPLADASCELIASVFSPID 156
Cdd:PRK11088  84 eKATALLDIGCGEGYYTHALADALPEittMQLFGLDISKVAIKYAAKRYPQVTFCVASSHRLPFADQSLDAIIRIYAPCK 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358  157 WNEAVRILSPGGGVLRLGPASAHLLELRQRLYDDVRDYAD-DKHLAGlpaqLRLRHTETLEFRLALDSYDAReNLLAMTP 235
Cdd:PRK11088 164 AEELARVVKPGGIVITVTPGPRHLFELKGLIYDEVRLHAPeAEQLEG----FELQHSERLAYPMRLTGSEAV-ALLQMTP 238

                        250
                 ....*....|....*..
gi 15596358  236 HGWRVNPERRARILAEP 252
Cdd:PRK11088 239 FAWKATPEVKQQLAAKG 255
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 63-187 1.78e-17

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 76.96  E-value: 1.78e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358  63 AGHYApLARRLAELAAERAPRRWLDIGCGEGYYSARLGEalAGAEGYALDISREAVKRACRRAP----QLSWLVASMARL 138
Cdd:COG2226   5 AARYD-GREALLAALGLRPGARVLDLGCGTGRLALALAE--RGARVTGVDISPEMLELARERAAeaglNVEFVVGDAEDL 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15596358 139 PLADASCELIASVFSPIDW-------NEAVRILSPGGGVLRLGPASAHLLELRQRL 187
Cdd:COG2226  82 PFPDGSFDLVISSFVLHHLpdperalAEIARVLKPGGRLVVVDFSPPDLAELEELL 137
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 86-168 9.05e-14

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 65.28  E-value: 9.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358    86 LDIGCGEGYYSARLGEALaGAEGYALDISREAVKRACRRA----PQLSWLVASMARLPLADASCELIASV-----FSPID 156
Cdd:pfam13649   2 LDLGCGTGRLTLALARRG-GARVTGVDLSPEMLERARERAaeagLNVEFVQGDAEDLPFPDGSFDLVVSSgvlhhLPDPD 80

                          90
                  ....*....|....*.
gi 15596358   157 W----NEAVRILSPGG 168
Cdd:pfam13649  81 LeaalREIARVLKPGG 96
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 71-168 1.17e-13

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 66.19  E-value: 1.17e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358  71 RRLAELAAERAP--RRWLDIGCGEGYYSARLgeALAGAEGYALDISREAVKRACRRAPQL--SWLVASMARLPLADASCE 146
Cdd:COG2227  12 RRLAALLARLLPagGRVLDVGCGTGRLALAL--ARRGADVTGVDISPEALEIARERAAELnvDFVQGDLEDLPLEDGSFD 89

                        90       100
                ....*....|....*....|....*....
gi 15596358 147 LIAS------VFSPIDW-NEAVRILSPGG 168
Cdd:COG2227  90 LVICsevlehLPDPAALlRELARLLKPGG 118
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
81-168 7.00e-13

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 63.30  E-value: 7.00e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358  81 APRRWLDIGCGEGYYSARLGEALAGAEGYALDISREAVKRACRRAPQLSWLVASMARLPLaDASCELIASVFSpIDW--- 157
Cdd:COG4106   1 PPRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARLPNVRFVVADLRDLDP-PEPFDLVVSNAA-LHWlpd 78

                        90
                ....*....|....*.
gi 15596358 158 -----NEAVRILSPGG 168
Cdd:COG4106  79 haallARLAAALAPGG 94
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 86-168 1.72e-12

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 61.91  E-value: 1.72e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358    86 LDIGCGEGYYSARLgeALAGAEGYALDISREAVKRACRRAP--QLSWLVASMARLPLADASCELIASVFSpIDW------ 157
Cdd:pfam08241   1 LDVGCGTGLLTELL--ARLGARVTGVDISPEMLELAREKAPreGLTFVVGDAEDLPFPDNSFDLVLSSEV-LHHvedper 77

                          90
                  ....*....|...
gi 15596358   158 --NEAVRILSPGG 168
Cdd:pfam08241  78 alREIARVLKPGG 90
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 82-185 6.28e-12

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 63.46  E-value: 6.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358    82 PRRWLDIGCGEGYYSARLGEALAGAEGYALDISREAVKRACRR-APQLSWLVASMARLPLADASCELIASVfSPIDW--- 157
Cdd:TIGR02072  35 PASVLDIGCGTGYLTRALLKRFPQAEFIALDISAGMLAQAKTKlSENVQFICGDAEKLPLEDSSFDLIVSN-LALQWcdd 113

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 15596358   158 -----NEAVRILSPGGGVL--RLGPASAHllELRQ 185
Cdd:TIGR02072 114 lsqalSELARVLKPGGLLAfsTFGPGTLH--ELRQ 146
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 68-231 1.18e-09

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 56.46  E-value: 1.18e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358  68 PLARRLAELAAERAPRRWLDIGCGEGYYSARLGEALaGAEGYALDISREAVKRACRRAPQL-----SWLVASMARL-PLA 141
Cdd:COG0500  13 GLAALLALLERLPKGGRVLDLGCGTGRNLLALAARF-GGRVIGIDLSPEAIALARARAAKAglgnvEFLVADLAELdPLP 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358 142 DASCELI--ASVFSPID-------WNEAVRILSPGGGVLrLGPASAHLLELRQRLYDDVRDYADDKHLAG----LPAQLR 208
Cdd:COG0500  92 AESFDLVvaFGVLHHLPpeerealLRELARALKPGGVLL-LSASDAAAALSLARLLLLATASLLELLLLLrllaLELYLR 170

                       170       180
                ....*....|....*....|...
gi 15596358 209 LRHTETLEFRLALDSYDARENLL 231
Cdd:COG0500 171 ALLAAAATEDLRSDALLESANAL 193
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
69-168 2.07e-08

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 52.69  E-value: 2.07e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358  69 LARRLAELAAERAPRRWLDIGCGEGYYSARLgeALAGAEGYALDISREAVKRACRRAPQLSWLVASMARLPLADASCELI 148
Cdd:COG4976  34 LAEELLARLPPGPFGRVLDLGCGTGLLGEAL--RPRGYRLTGVDLSEEMLAKAREKGVYDRLLVADLADLAEPDGRFDLI 111

                        90       100
                ....*....|....*....|....*..
gi 15596358 149 AS--VFSPI-DWNE----AVRILSPGG 168
Cdd:COG4976 112 VAadVLTYLgDLAAvfagVARALKPGG 138
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 86-168 1.48e-07

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 48.52  E-value: 1.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358    86 LDIGCGEGYYSARLGEALAGAEGYALDISREAVKRACRRAPQLSWLVASMARLPLADASCE--------LIASVFSPID- 156
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERLAALGLLNAVRVELFQLDLGELdpgsfdvvVASNVLHHLAd 80

                          90
                  ....*....|....*.
gi 15596358   157 ----WNEAVRILSPGG 168
Cdd:pfam08242  81 pravLRNIRRLLKPGG 96
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 68-168 7.47e-06

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 44.92  E-value: 7.47e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358  68 PLARRLAELAAERAPRRWLDIGCGEGYYSARLGEALaGAEGYALDISREAVKRACRRA------PQLSWLVASMARLPlA 141
Cdd:COG2230  38 AKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARRY-GVRVTGVTLSPEQLEYARERAaeaglaDRVEVRLADYRDLP-A 115

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 15596358 142 DASCELIASV-----FSPIDWNEAV----RILSPGG 168
Cdd:COG2230 116 DGQFDAIVSIgmfehVGPENYPAYFakvaRLLKPGG 151
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 84-168 1.30e-05

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 43.19  E-value: 1.30e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358  84 RWLDIGCGEGYYSARLGEALaGAEGYALDISREAVKRA-----CRRAPQLSWLVASMARLPL-ADASCELIASVFSPIDW 157
Cdd:cd02440   1 RVLDLGCGTGALALALASGP-GARVTGVDISPVALELArkaaaALLADNVEVLKGDAEELPPeADESFDVIISDPPLHHL 79

                        90
                ....*....|....*....
gi 15596358 158 --------NEAVRILSPGG 168
Cdd:cd02440  80 vedlarflEEARRLLKPGG 98
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 63-185 1.76e-05

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 44.75  E-value: 1.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358   63 AGHY---APLARRLAELAAERAPRRW----LDIGCGEGYYSARLGEAlaGAEGYALDISREAVKRACRRAPQLSWLVASM 135
Cdd:PRK10258  17 AAHYeqhAELQRQSADALLAMLPQRKfthvLDAGCGPGWMSRYWRER--GSQVTALDLSPPMLAQARQKDAADHYLAGDI 94

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 15596358  136 ARLPLADASCELIASVFSpIDW--------NEAVRILSPGGGVLRLGPASAHLLELRQ 185
Cdd:PRK10258  95 ESLPLATATFDLAWSNLA-VQWcgnlstalRELYRVVRPGGVVAFTTLVQGSLPELHQ 151
PRK08317 PRK08317
hypothetical protein; Provisional
 71-171 2.76e-05

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 44.16  E-value: 2.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358   71 RRLAELAAERAPRRWLDIGCGEGYYSARLGEALaGAEG--YALDISREAVKRACRRA----PQLSWLVASMARLPLADAS 144
Cdd:PRK08317   9 ARTFELLAVQPGDRVLDVGCGPGNDARELARRV-GPEGrvVGIDRSEAMLALAKERAaglgPNVEFVRGDADGLPFPDGS 87

                         90       100       110
                 ....*....|....*....|....*....|....
gi 15596358  145 CELIAS--VFSPID-----WNEAVRILSPGGGVL 171
Cdd:PRK08317  88 FDAVRSdrVLQHLEdparaLAEIARVLRPGGRVV 121
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 86-171 4.17e-05

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 42.79  E-value: 4.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358    86 LDIGCGEGYYSARL-GEALAGAEGYALDISREAVKRACRRAPQL-----SWLVASMARLP--LADAS-------CELIAS 150
Cdd:pfam13847   8 LDLGCGTGHLSFELaEELGPNAEVVGIDISEEAIEKARENAQKLgfdnvEFEQGDIEELPelLEDDKfdvvisnCVLNHI 87

                          90       100
                  ....*....|....*....|.
gi 15596358   151 VFSPIDWNEAVRILSPGGGVL 171
Cdd:pfam13847  88 PDPDKVLQEILRVLKPGGRLI 108
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 63-127 4.16e-04

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 40.59  E-value: 4.16e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15596358   63 AGHYAPLARRLAELAAERAP--RRWLDIGCGEGYYSARLgeALAGAEGYALDISREAVKRACRRAPQ 127
Cdd:PRK07580  43 AGHQRMRDTVLSWLPADGDLtgLRILDAGCGVGSLSIPL--ARRGAKVVASDISPQMVEEARERAPE 107
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
75-203 8.43e-04

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 39.73  E-value: 8.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358    75 ELAAERAPRRWLDIGCGEGYYSARLGEAlAGAEG--YALDISREAVKRACRRAP-----QLSWLVASMARLPLADASCEL 147
Cdd:pfam01209  36 KCMGVKRGNKFLDVAGGTGDWTFGLSDS-AGSSGkvVGLDINENMLKEGEKKAKeegkyNIEFLQGNAEELPFEDDSFDI 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596358   148 IASVFS-------PIDWNEAVRILSPGGGVL-------------------------RLGPASAHLLELRQRLYDDVRDYA 195
Cdd:pfam01209 115 VTISFGlrnfpdyLKVLKEAFRVLKPGGRVVclefskpenpllsqayelyfkyvmpFMGKMFAKSYKSYQYLQESIRDFP 194


                  ....*...
gi 15596358   196 DDKHLAGL 203
Cdd:pfam01209 195 DQKTLASM 202
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 69-121 1.02e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 38.95  E-value: 1.02e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 15596358    69 LARRLAELAAE-RAPRRWLDIGCGEGYYSARLGEalAGAEGYALDISREAVKRA 121
Cdd:pfam13489   9 LADLLLRLLPKlPSPGRVLDFGCGTGIFLRLLRA--QGFSVTGVDPSPIAIERA 60
PRK14968 PRK14968
putative methyltransferase; Provisional
 73-125 1.04e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 39.11  E-value: 1.04e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 15596358   73 LAELAAERAPRRWLDIGCGEGYYSARLgeALAGAEGYALDISREAVKRACRRA 125
Cdd:PRK14968  15 LAENAVDKKGDRVLEVGTGSGIVAIVA--AKNGKKVVGVDINPYAVECAKCNA 65
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 70-124 2.64e-03

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 37.86  E-value: 2.64e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15596358  70 ARRLAELAAERAPRRWLDIGCGEGYYSARLGEALAGAEGYALDISREAVkRACRR 124
Cdd:COG2813  38 TRLLLEHLPEPLGGRVLDLGCGYGVIGLALAKRNPEARVTLVDVNARAV-ELARA 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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