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Conserved domains on  [gi|15597175|ref|NP_250669|]
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sensor kinase EraS [Pseudomonas aeruginosa PAO1]

Protein Classification

sensor histidine kinase( domain architecture ID 11468388)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals, such as Bacillus subtilis thermosensor DesK which regulates the order of membrane lipids by controlling the expression of the gene encoding delta 5-acyl-lipid desaturase, oxygen sensor histidine kinase NreB which is involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen, sensor histidine kinase LiaS which is involved in sensing cell wall stress, and Staphylococcus aureus VraS which positively modulates cell wall biosynthesis

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0005524|GO:0004673|GO:0007165|GO:0000155
PubMed:  10500846|10339418|10637609
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
15-215 3.25e-54

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


:

Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 173.65  E-value: 3.25e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175  15 LLAVQERERRLLAQAVHDDIGQYLTGIRTQL-LLLRCTAGDGQPALARLERYCQGLDDS---FRALLRGLPPPALQRQSL 90
Cdd:COG4585  46 AEEAREEERRRIARELHDGVGQSLSAIKLQLeAARRLLDADPEAAREELEEIRELAREAlaeLRRLVRGLRPPALDDLGL 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175  91 DEALRACVADWQEGQGIACELRLGGPLPPLDAAAGTHLYRLLQEALNNVARHAGASRVRIRLQCRGGFLYLSVRDDGRGC 170
Cdd:COG4585 126 AAALEELAERLLRAAGIRVELDVDGDPDRLPPEVELALYRIVQEALTNALKHAGATRVTVTLEVDDGELTLTVRDDGVGF 205

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 15597175 171 AADPAP--GFGLDSMRQRARCLGAELSLRSRPGQGLALRLRMPLERD 215
Cdd:COG4585 206 DPEAAPggGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAAA 252
 
Name Accession Description Interval E-value
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
15-215 3.25e-54

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 173.65  E-value: 3.25e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175  15 LLAVQERERRLLAQAVHDDIGQYLTGIRTQL-LLLRCTAGDGQPALARLERYCQGLDDS---FRALLRGLPPPALQRQSL 90
Cdd:COG4585  46 AEEAREEERRRIARELHDGVGQSLSAIKLQLeAARRLLDADPEAAREELEEIRELAREAlaeLRRLVRGLRPPALDDLGL 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175  91 DEALRACVADWQEGQGIACELRLGGPLPPLDAAAGTHLYRLLQEALNNVARHAGASRVRIRLQCRGGFLYLSVRDDGRGC 170
Cdd:COG4585 126 AAALEELAERLLRAAGIRVELDVDGDPDRLPPEVELALYRIVQEALTNALKHAGATRVTVTLEVDDGELTLTVRDDGVGF 205

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 15597175 171 AADPAP--GFGLDSMRQRARCLGAELSLRSRPGQGLALRLRMPLERD 215
Cdd:COG4585 206 DPEAAPggGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAAA 252
PRK11644 PRK11644
signal transduction histidine-protein kinase/phosphatase UhpB;
13-208 1.74e-31

signal transduction histidine-protein kinase/phosphatase UhpB;


Pssm-ID: 236945 [Multi-domain]  Cd Length: 495  Bit Score: 119.70  E-value: 1.74e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175   13 RWLLAVQERERRLLAQAVHDDIGQYLTGIRTQLLLLRCTAGDGQPAL---ARLERYCQGLDDSFRALLRGLPPPALQRQS 89
Cdd:PRK11644 292 ERLLETEESVRRDVARELHDEIGQTITAIRTQAGIIKRLAADNASVKqsaQLIEQLSLGVYDTVRRLLGRLRPRQLDDLT 371

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175   90 LDEALRACVADWQ-EGQGIACELRLGGPLPPLDAAAGTHLYRLLQEALNNVARHAGASRVRIRLQCRGGFLYLSVRDDGR 168
Cdd:PRK11644 372 LEQAIRSLMREMElEDRGIVSHLDWRIDESALSETQRVTLFRVCQEGLNNIVKHADASAVTLQGWQQDERLMLVIEDDGS 451

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 15597175  169 GC-AADPAPGFGLDSMRQRARCLGAELSLRSRPGQGLALRL 208
Cdd:PRK11644 452 GLpPGSGQQGFGLRGMRERVTALGGTLTISCTHGTRLSVSL 492
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 128-211 2.46e-30

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 107.25  E-value: 2.46e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175 128 LYRLLQEALNNVARHAGASRVRIRLQCRGGFLYLSVRDDGRG---CAADPAPGFGLDSMRQRARCLGAELSLRSRPGQGL 204
Cdd:cd16917   1 LYRIVQEALTNALKHAGASRVRVTLSYTADELTLTVVDDGVGfdgPAPPGGGGFGLLGMRERAELLGGTLTIGSRPGGGT 80


                ....*..
gi 15597175 205 ALRLRMP 211
Cdd:cd16917  81 RVTARLP 87
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 126-214 1.16e-14

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 67.39  E-value: 1.16e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175   126 THLYRLLQEALNNVARHAG-ASRVRIRLQcRGGFLYLSVRDDGRGCAADPAP-----------------GFGLDSMRQRA 187
Cdd:pfam02518   4 LRLRQVLSNLLDNALKHAAkAGEITVTLS-EGGELTLTVEDNGIGIPPEDLPrifepfstadkrggggtGLGLSIVRKLV 82

                          90       100
                  ....*....|....*....|....*..
gi 15597175   188 RCLGAELSLRSRPGQGLALRLRMPLER 214
Cdd:pfam02518  83 ELLGGTITVESEPGGGTTVTLTLPLAQ 109
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 126-213 5.85e-13

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 62.67  E-value: 5.85e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175    126 THLYRLLQEALNNVARHAGA-SRVRIRLQCRGGFLYLSVRDDGRGCAADPAP-------------------GFGLDSMRQ 185
Cdd:smart00387   4 DRLRQVLSNLLDNAIKYTPEgGRITVTLERDGDHVEITVEDNGPGIPPEDLEkifepffrtdkrsrkiggtGLGLSIVKK 83

                           90       100
                   ....*....|....*....|....*...
gi 15597175    186 RARCLGAELSLRSRPGQGLALRLRMPLE 213
Cdd:smart00387  84 LVELHGGEISVESEPGGGTTFTITLPLE 111
 
Name Accession Description Interval E-value
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
15-215 3.25e-54

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 173.65  E-value: 3.25e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175  15 LLAVQERERRLLAQAVHDDIGQYLTGIRTQL-LLLRCTAGDGQPALARLERYCQGLDDS---FRALLRGLPPPALQRQSL 90
Cdd:COG4585  46 AEEAREEERRRIARELHDGVGQSLSAIKLQLeAARRLLDADPEAAREELEEIRELAREAlaeLRRLVRGLRPPALDDLGL 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175  91 DEALRACVADWQEGQGIACELRLGGPLPPLDAAAGTHLYRLLQEALNNVARHAGASRVRIRLQCRGGFLYLSVRDDGRGC 170
Cdd:COG4585 126 AAALEELAERLLRAAGIRVELDVDGDPDRLPPEVELALYRIVQEALTNALKHAGATRVTVTLEVDDGELTLTVRDDGVGF 205

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 15597175 171 AADPAP--GFGLDSMRQRARCLGAELSLRSRPGQGLALRLRMPLERD 215
Cdd:COG4585 206 DPEAAPggGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAAA 252
UhpB COG3851
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction ...
 12-212 2.20e-45

Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction mechanisms];


Pssm-ID: 443060 [Multi-domain]  Cd Length: 493  Bit Score: 157.09  E-value: 2.20e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175  12 YRWLLAVQERERRLLAQAVHDDIGQYLTGIRTQLLLLRCTAGDGQP--ALARLERYCQGLDDSFRALLRGLPPPALQRQS 89
Cdd:COG3851 282 ARQLVSAEESERREIARELHDEIGQNITAIRTQASILKRLAPQPEIeqSAQSIESLALRIYDTTRRLLDRLRPAVLDELG 361

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175  90 LDEALRACVADWQ-EGQGIACELRLGGPLPPLDAAAGTHLYRLLQEALNNVARHAGASRVRIRLQCRGGFLYLSVRDDGR 168
Cdd:COG3851 362 LEEALRELPRELAfEEPGISCQLDLRGDPSLLDDTLQLTLYRLVQEALTNILKHAEASQIRISLSQDKRLLSLEIRDDGI 441

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 15597175 169 GCAAD-PAPGFGLDSMRQRARCLGAELSLRSRPgQGLALRLRMPL 212
Cdd:COG3851 442 GLPPElRAKGFGLRGMRERVRALGGDFRLSSAP-KGTRLSVLLPT 485
PRK11644 PRK11644
signal transduction histidine-protein kinase/phosphatase UhpB;
13-208 1.74e-31

signal transduction histidine-protein kinase/phosphatase UhpB;


Pssm-ID: 236945 [Multi-domain]  Cd Length: 495  Bit Score: 119.70  E-value: 1.74e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175   13 RWLLAVQERERRLLAQAVHDDIGQYLTGIRTQLLLLRCTAGDGQPAL---ARLERYCQGLDDSFRALLRGLPPPALQRQS 89
Cdd:PRK11644 292 ERLLETEESVRRDVARELHDEIGQTITAIRTQAGIIKRLAADNASVKqsaQLIEQLSLGVYDTVRRLLGRLRPRQLDDLT 371

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175   90 LDEALRACVADWQ-EGQGIACELRLGGPLPPLDAAAGTHLYRLLQEALNNVARHAGASRVRIRLQCRGGFLYLSVRDDGR 168
Cdd:PRK11644 372 LEQAIRSLMREMElEDRGIVSHLDWRIDESALSETQRVTLFRVCQEGLNNIVKHADASAVTLQGWQQDERLMLVIEDDGS 451

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 15597175  169 GC-AADPAPGFGLDSMRQRARCLGAELSLRSRPGQGLALRL 208
Cdd:PRK11644 452 GLpPGSGQQGFGLRGMRERVTALGGTLTISCTHGTRLSVSL 492
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 128-211 2.46e-30

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 107.25  E-value: 2.46e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175 128 LYRLLQEALNNVARHAGASRVRIRLQCRGGFLYLSVRDDGRG---CAADPAPGFGLDSMRQRARCLGAELSLRSRPGQGL 204
Cdd:cd16917   1 LYRIVQEALTNALKHAGASRVRVTLSYTADELTLTVVDDGVGfdgPAPPGGGGFGLLGMRERAELLGGTLTIGSRPGGGT 80


                ....*..
gi 15597175 205 ALRLRMP 211
Cdd:cd16917  81 RVTARLP 87
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
4-213 9.13e-16

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 74.56  E-value: 9.13e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175   4 LRPAGPAEYRWLLAVQERERRLLAQAVHDdIGQYLTGIRTQL-LLLRCTAGDGQPALARLERYCQGLDDSFRALL----- 77
Cdd:COG0642  92 LLLLLLALLLLLEEANEAKSRFLANVSHE-LRTPLTAIRGYLeLLLEELDEEQREYLETILRSADRLLRLINDLLdlsrl 170

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175  78 -RGLPPPALQRQSLDEALRACVADWQ---EGQGIACELRLGGPLPPLDAAAgTHLYRLLQEALNNVARHAGA-SRVRIRL 152
Cdd:COG0642 171 eAGKLELEPEPVDLAELLEEVVELFRplaEEKGIELELDLPDDLPTVRGDP-DRLRQVLLNLLSNAIKYTPEgGTVTVSV 249

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15597175 153 QCRGGFLYLSVRDDGRGCAADPAP------------------GFGLDSMRQRARCLGAELSLRSRPGQGLALRLRMPLE 213
Cdd:COG0642 250 RREGDRVRISVEDTGPGIPPEDLErifepffrtdpsrrgggtGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPLA 328
PRK10935 PRK10935
nitrate/nitrite two-component system sensor histidine kinase NarQ;
16-211 9.01e-15

nitrate/nitrite two-component system sensor histidine kinase NarQ;


Pssm-ID: 236800 [Multi-domain]  Cd Length: 565  Bit Score: 72.19  E-value: 9.01e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175   16 LAVQErERRLLAQAVHDDIGQYLTGIRTQLLLL-RCTAGDGQPALARLERYCQGLDDSFRALlRGLPPP---ALQRQSLD 91
Cdd:PRK10935 358 LLLME-ERATIARELHDSLAQVLSYLKIQLTLLkRSLDEDNAKAQSIIAEFDQALSDAYRQL-RELLTTfrlTIQEANLG 435

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175   92 EALRACVADWQeGQGIA-----CELrlggPLPPLDAAAGTHLYRLLQEALNNVARHAGASRVRIRLQCR-GGFLYLSVRD 165
Cdd:PRK10935 436 SALEEMLDQLR-NQTDAkitldCRL----PSQALDAQQQVHLLQIIREATLNAIKHANASEIAVSCVTNpDGEHTVSIRD 510

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 15597175  166 DGRGCA--ADPAPGFGLDSMRQRARCLGAELSLRSRPGQGLALRLRMP 211
Cdd:PRK10935 511 DGIGIGelKEPEGHYGLNIMQERAERLGGTLTISQPPGGGTTVSLTFP 558
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 126-214 1.16e-14

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 67.39  E-value: 1.16e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175   126 THLYRLLQEALNNVARHAG-ASRVRIRLQcRGGFLYLSVRDDGRGCAADPAP-----------------GFGLDSMRQRA 187
Cdd:pfam02518   4 LRLRQVLSNLLDNALKHAAkAGEITVTLS-EGGELTLTVEDNGIGIPPEDLPrifepfstadkrggggtGLGLSIVRKLV 82

                          90       100
                  ....*....|....*....|....*..
gi 15597175   188 RCLGAELSLRSRPGQGLALRLRMPLER 214
Cdd:pfam02518  83 ELLGGTITVESEPGGGTTVTLTLPLAQ 109
PRK10600 PRK10600
nitrate/nitrite two-component system sensor histidine kinase NarX;
22-209 4.80e-13

nitrate/nitrite two-component system sensor histidine kinase NarX;


Pssm-ID: 182581 [Multi-domain]  Cd Length: 569  Bit Score: 67.39  E-value: 4.80e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175   22 ERRLLAQAVHDDIGQYLTGIRTQLLLLRCTAGD-GQPALARLERYCQGLDDSFRALLRGLPPPALQ--RQSLDEALRACV 98
Cdd:PRK10600 361 ERATIARELHDSIAQSLSCMKMQVSCLQMQGDAlPESSRELLSQIRNELNASWRQLRELLTTFRLQltEPGLRPALEASC 440

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175   99 ADWQEGQGIACELRLGGPLPPLDAAAGTHLYRLLQEALNNVARHAGASRVRIRLQCRGGFLYLSVRDDGRGC--AADPAP 176
Cdd:PRK10600 441 EEFSARFGFPVKLDYQLPPRLVPSHQAIHLLQIAREALSNALKHAQASEVVVTVAQNQNQVKLSVQDNGCGVpeNAERSN 520

                        170       180       190
                 ....*....|....*....|....*....|...
gi 15597175  177 GFGLDSMRQRARCLGAELSLRSRPGQGLALRLR 209
Cdd:PRK10600 521 HYGLIIMRDRAQSLRGDCRVRRRESGGTEVVVT 553
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 126-213 5.85e-13

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 62.67  E-value: 5.85e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175    126 THLYRLLQEALNNVARHAGA-SRVRIRLQCRGGFLYLSVRDDGRGCAADPAP-------------------GFGLDSMRQ 185
Cdd:smart00387   4 DRLRQVLSNLLDNAIKYTPEgGRITVTLERDGDHVEITVEDNGPGIPPEDLEkifepffrtdkrsrkiggtGLGLSIVKK 83

                           90       100
                   ....*....|....*....|....*...
gi 15597175    186 RARCLGAELSLRSRPGQGLALRLRMPLE 213
Cdd:smart00387  84 LVELHGGEISVESEPGGGTTFTITLPLE 111
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
38-214 1.03e-11

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 62.23  E-value: 1.03e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175  38 LTGIRTQLLLLRctaGDGQPALARLERYCQGLDDSFRALLR-------------GLPPPALQRQSLDEALRACVADWQ-- 102
Cdd:COG2205  31 LTSILGAAELLL---DEEDLSPEERRELLEIIRESAERLLRliedlldlsrlesGKLSLELEPVDLAELLEEAVEELRpl 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175 103 -EGQGIACELRLGGPLPPLDAAAgTHLYRLLQEALNNVARHAGA-SRVRIRLQCRGGFLYLSVRDDGRGCAADPAP---- 176
Cdd:COG2205 108 aEEKGIRLELDLPPELPLVYADP-ELLEQVLANLLDNAIKYSPPgGTITISARREGDGVRISVSDNGPGIPEEELErife 186

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 15597175 177 --------------GFGLDSMRQRARCLGAELSLRSRPGQGLALRLRMPLER 214
Cdd:COG2205 187 rfyrgdnsrgeggtGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAE 238
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 71-215 1.80e-09

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 56.51  E-value: 1.80e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175  71 DSFRALLRgLPPPALQRQSLDEALRACVA---DWQEGQGIACELRLGGPLPPLDAAAgthlyRLLQEALNNV---ARHAG 144
Cdd:COG5000 260 DEFLDFAR-LPEPQLEPVDLNELLREVLAlyePALKEKDIRLELDLDPDLPEVLADR-----DQLEQVLINLlknAIEAI 333

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175 145 AS--RVRIRLQCRGGFLYLSVRDDGRGCAADPAP--------------GFGLdSM-RQRARCLGAELSLRSRPGQGLALR 207
Cdd:COG5000 334 EEggEIEVSTRREDGRVRIEVSDNGPGIPEEVLErifepffttkpkgtGLGL-AIvKKIVEEHGGTIELESRPGGGTTFT 412


                ....*...
gi 15597175 208 LRMPLERD 215
Cdd:COG5000 413 IRLPLAEE 420
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 33-212 2.05e-07

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 50.57  E-value: 2.05e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175  33 DIGQYLTGIRTQL-LLLRCTAGDGQPALAR--LERYCQGLD------DSFRALLRGlPPPALQRQSLDEALRACVADWQ- 102
Cdd:COG4191 152 EINNPLAAILGNAeLLRRRLEDEPDPEELReaLERILEGAEraaeivRSLRAFSRR-DEEEREPVDLNELIDEALELLRp 230

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175 103 --EGQGIACELRLGGPLPPLDAAAGthlyrLLQEALNNV---ARHA----GASRVRIRLQCRGGFLYLSVRDDGRGCAAD 173
Cdd:COG4191 231 rlKARGIEVELDLPPDLPPVLGDPG-----QLEQVLLNLlinAIDAmeegEGGRITISTRREGDYVVISVRDNGPGIPPE 305

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15597175 174 PAP----------------GFGLdSM-RQRARCLGAELSLRSRPGQGLALRLRMPL 212
Cdd:COG4191 306 VLErifepffttkpvgkgtGLGL-SIsYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
HisKA_3 pfam07730
Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of ...
 22-85 5.92e-07

Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with pfam00512 and pfam07536.


Pssm-ID: 429624 [Multi-domain]  Cd Length: 68  Bit Score: 45.30  E-value: 5.92e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15597175    22 ERRLLAQAVHDDIGQYLTGIRTQLLLLRCTAGDG----QPALARLERYCQGLDDSFRALLRGLPPPAL 85
Cdd:pfam07730   1 ERNRIARELHDSVGQSLTAIKLQLELARRLLDRDpeeaREQLDAIRELAREALQELRRLLGDLRPPAL 68
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 110-214 7.67e-07

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 48.75  E-value: 7.67e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175 110 ELRLGGPLPPLDAAAGTHLYRLLQEALNNVARHAGAS----RVRIRLQCRGGFLYLSVRDDGRGCAADPAP----GFGLD 181
Cdd:COG3920 382 RIELDGPDVELPADAAVPLGLILNELVTNALKHAFLSgeggRIRVSWRREDGRLRLTVSDNGVGLPEDVDPparkGLGLR 461

                        90       100       110
                ....*....|....*....|....*....|...
gi 15597175 182 SMRQRARCLGAELSLRSRPgqGLALRLRMPLER 214
Cdd:COG3920 462 LIRALVRQLGGTLELDRPE--GTRVRITFPLAE 492
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 105-215 2.16e-06

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 47.54  E-value: 2.16e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175 105 QGIACELRLGGPLPPLDAAAgTHLYRLLQEALNNVARHAGAS-----RVRIRLQCRGGFLYLSVRDDGRGCAADPAP--- 176
Cdd:COG3290 260 RGIDLTIDIDSDLPDLPLSD-TDLVTILGNLLDNAIEAVEKLpeeerRVELSIRDDGDELVIEVEDSGPGIPEELLEkif 338

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 15597175 177 ------------GFGLDSMRQRARCLGAELSLRSRPGQGLALRLRMPLERD 215
Cdd:COG3290 339 ergfstklgegrGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
147-215 8.70e-06

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 45.78  E-value: 8.70e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175 147 RVRIRLQCRGGFLYLSVRDDGRGCAADPAP-------------GFGLDSMRQRARCL---GAELSLRSRPGQGLALRLRM 210
Cdd:COG2972 361 TIRISIRKEGDRLVITVEDNGVGMPEEKLEklleelsskgegrGIGLRNVRERLKLYygeEYGLEIESEPGEGTTVTIRI 440


                ....*
gi 15597175 211 PLERD 215
Cdd:COG2972 441 PLEEE 445
PRK10604 PRK10604
sensor protein RstB; Provisional
 13-212 1.29e-05

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 44.98  E-value: 1.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175   13 RWLLAVQERERRLLAQAVHDDIGQyLTGIRTQLLLLrctagdgqpalARLERycqglddsfrallrglPPPALQRQSLDE 92
Cdd:PRK10604 231 RYRLEMSDNLSAAESQALNRDIGQ-LEALIEELLTY-----------ARLDR----------------PQNELHLSEPDL 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175   93 A--LRACVADWQEGQGiACELRLGGPLPPLDAAAGTHLY-RLLQEALNNVARHAGaSRVRIRLQCRGGFLYLSVRDDGRG 169
Cdd:PRK10604 283 PawLSTHLADIQAVTP-EKTVRLDTPHQGDYGALDMRLMeRVLDNLLNNALRYAH-SRVRVSLLLDGNQACLIVEDDGPG 360

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15597175  170 CAADPAP--------------------GFGLDSMRQRARCLGAELSLRSRPGQGLALRLRMPL 212
Cdd:PRK10604 361 IPPEERErvfepfvrldpsrdratggcGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPV 423
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
85-215 2.74e-05

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 44.16  E-value: 2.74e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175  85 LQRQSLDEALRACVADWQ---EGQGIACELRLGGPLPPLDAAAgTHLYRLLQEALNNVARHAGA-SRVRIRLQCRGGFLY 160
Cdd:COG5002 237 KEPVDLAELLEEVVEELRplaEEKGIELELDLPEDPLLVLGDP-DRLEQVLTNLLDNAIKYTPEgGTITVSLREEDDQVR 315

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15597175 161 LSVRDDGRGCAADPAPG-----FGLDSMRQR---------------ARCLGAELSLRSRPGQGLALRLRMPLERD 215
Cdd:COG5002 316 ISVRDTGIGIPEEDLPRiferfYRVDKSRSRetggtglglaivkhiVEAHGGRIWVESEPGKGTTFTITLPLARE 390
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
132-212 3.33e-05

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 41.82  E-value: 3.33e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175 132 LQEALNNVARHAGAS----RVRIRLQCRGGFLYLSVRDDGRG----CAADPAP-----GFGLDSMRQrarcLGAELSLRS 198
Cdd:COG2172  39 VSEAVTNAVRHAYGGdpdgPVEVELELDPDGLEIEVRDEGPGfdpeDLPDPYStlaegGRGLFLIRR----LMDEVEYES 114

                        90
                ....*....|....
gi 15597175 199 RPGqGLALRLRMPL 212
Cdd:COG2172 115 DPG-GTTVRLVKRL 127
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 16-214 1.21e-04

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 42.58  E-value: 1.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175   16 LAVQERERRLLAQAVHDDIGQYLTG----IRTQLLLLRCTAG--DGQPALARLERYCQGLDDSFRALLRGL--------- 80
Cdd:PRK11466 426 LVIEHRQARAEAEKASQAKSAFLAAmsheIRTPLYGILGTAQllADNPALNAQRDDLRAITDSGESLLTILndildysai 505

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175   81 ----------PPPALQRQSLDEALRACVADWQeGQGIACELRLGGPLPPLDAAAGTHLYRLLQEALNNVARHAGASRVRI 150
Cdd:PRK11466 506 eaggknvsvsDEPFEPRPLLESTLQLMSGRVK-GRPIRLATDIADDLPTALMGDPRRIRQVITNLLSNALRFTDEGSIVL 584

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175  151 RLQCRGGFLYLSVRDDGrgCAADPA------------------PGFGLDSMRQRARCLGAELSLRSRPGQGLALRLRMPL 212
Cdd:PRK11466 585 RSRTDGEQWLVEVEDSG--CGIDPAklaeifqpfvqvsgkrggTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPL 662


                 ..
gi 15597175  213 ER 214
Cdd:PRK11466 663 RV 664
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 58-212 1.45e-04

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 42.14  E-value: 1.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175   58 ALARLERYcQGLDDsfrallrglpppaLQRQSLDEALRACVADWQ---EGQGIACELRLGGPLPPLDAAagthlyrLLQE 134
Cdd:PRK11100 313 ELARLEQR-QELEV-------------LEPVALAALLEELVEAREaqaAAKGITLRLRPDDARVLGDPF-------LLRQ 371

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175  135 ALNNVARHA-----GASRVRIRLQCRGGFLYLSVRDDGRGcAADPA--------------------PGFGLDSMRQRARC 189
Cdd:PRK11100 372 ALGNLLDNAidfspEGGTITLSAEVDGEQVALSVEDQGPG-IPDYAlpriferfyslprpangrksTGLGLAFVREVARL 450

                        170       180
                 ....*....|....*....|...
gi 15597175  190 LGAELSLRSRPGQGLALRLRMPL 212
Cdd:PRK11100 451 HGGEVTLRNRPEGGVLATLTLPR 473
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 131-211 9.76e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 37.43  E-value: 9.76e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175 131 LLQEALNNVARHA-----GASRVRIRLQCRGGFLYLSVRDDGRGCAADPAP----------GFGLDSMRQRARCL---GA 192
Cdd:cd16924   5 TLQPLVENAIQHGlspltDKGVVTISALKEDNHVMIEVEDNGRGIDPKVLNilgkkpkegnGIGLYNVHQRLILLfgeDY 84

                        90
                ....*....|....*....
gi 15597175 193 ELSLRSRPGQGLALRLRMP 211
Cdd:cd16924  85 GIHIASEPDKGTRITFTIP 103
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 131-211 1.45e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 36.88  E-value: 1.45e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175 131 LLQEALNNVAR-HAGASRVRIRLQCRGGFLYLSVRDDGRGCAADPAP---------------GFGLDSMRQRARCLGAEL 194
Cdd:cd16915   8 LIDNALDALAAtGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDkvfergvstkgqgerGIGLALVRQSVERLGGSI 87

                        90
                ....*....|....*..
gi 15597175 195 SLRSRPGQGLALRLRMP 211
Cdd:cd16915  88 TVESEPGGGTTFSIRIP 104
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
38-216 1.99e-03

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 38.29  E-value: 1.99e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175  38 LTGIR--TQLLLLRCTAGDGQPALARLERYC---QGLDDSFRALLRGlPPPALQRQSLDEALRACVADWQE--GQGIACE 110
Cdd:COG3852 150 LTGIRgaAQLLERELPDDELREYTQLIIEEAdrlNNLVDRLLSFSRP-RPPEREPVNLHEVLERVLELLRAeaPKNIRIV 228

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175 111 LRLGGPLPPLDAAAGthlyrLLQEALNNV---ARHAGASRVRIRLQCR------------GGFLYLSVRDDGRGCAADPA 175
Cdd:COG3852 229 RDYDPSLPEVLGDPD-----QLIQVLLNLvrnAAEAMPEGGTITIRTRverqvtlgglrpRLYVRIEVIDNGPGIPEEIL 303

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15597175 176 P--------------GFGLdSMRQR-ARCLGAELSLRSRPGQGLALRLRMPLERDD 216
Cdd:COG3852 304 DrifepffttkekgtGLGL-AIVQKiVEQHGGTIEVESEPGKGTTFRIYLPLEQAE 358
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 128-187 2.08e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 36.64  E-value: 2.08e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15597175 128 LYRLLQEALNNVARHAgASRVRIRLQCRGGFLYLSVRDDGRGCAADP-----APGFGLDSMRQRA 187
Cdd:cd16939   1 MARALDNLLRNALRYA-HRTVRIALLVSGGRLTLIVEDDGPGIPAAArervfEPFVRLDPSRDRA 64
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 131-177 2.66e-03

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 35.71  E-value: 2.66e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 15597175 131 LLQEALNNVARHAGAS----RVRIRLQCRGGFLYLSVRDDGRGCAADPAPG 177
Cdd:cd16936   4 AVSEAVTNAVRHAYRHdgpgPVRLELDLDPDRLRVEVTDSGPGFDPLRPAD 54
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 128-211 8.54e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 34.73  E-value: 8.54e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597175 128 LYRLLQEALNNVARHAGASrVRIRLQCRGGFLYLSVRDDGRGCAADPAP------------------GFGLDSMRQRARC 189
Cdd:cd16950   1 LKRVLSNLVDNALRYGGGW-VEVSSDGEGNRTRIQVLDNGPGIAPEEVDelfqpfyrgdnargtsgtGLGLAIVQRISDA 79

                        90       100
                ....*....|....*....|..
gi 15597175 190 LGAELSLRSRPGQGLALRLRMP 211
Cdd:cd16950  80 HGGSLTLANRAGGGLCARIELP 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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