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Conserved domains on  [gi|15597181|ref|NP_250675|]
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coenzyme PQQ synthesis protein A [Pseudomonas aeruginosa PAO1]

Protein Classification

pyrroloquinoline quinone precursor peptide PqqA( domain architecture ID 10011357)

pyrroloquinoline quinone precursor peptide PqqA is required for coenzyme pyrroloquinoline quinone (PQQ) biosynthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
pqqA PRK00284
pyrroloquinoline quinone precursor peptide PqqA;
1-23 5.09e-10

pyrroloquinoline quinone precursor peptide PqqA;


:

Pssm-ID: 178960  Cd Length: 23  Bit Score: 46.45  E-value: 5.09e-10
                        10        20
                ....*....|....*....|...
gi 15597181   1 MWTKPSFTDLRLGFEVTLYFANR 23
Cdd:PRK00284  1 AWTKPAYTELRVGMEVTMYFSAR 23
 
Name Accession Description Interval E-value
pqqA PRK00284
pyrroloquinoline quinone precursor peptide PqqA;
1-23 5.09e-10

pyrroloquinoline quinone precursor peptide PqqA;


Pssm-ID: 178960  Cd Length: 23  Bit Score: 46.45  E-value: 5.09e-10
                        10        20
                ....*....|....*....|...
gi 15597181   1 MWTKPSFTDLRLGFEVTLYFANR 23
Cdd:PRK00284  1 AWTKPAYTELRVGMEVTMYFSAR 23
PQQ_syn_pqqA TIGR02107
coenzyme PQQ precursor peptide PqqA; This model describes a very small protein, coenzyme PQQ ...
 2-22 4.28e-08

coenzyme PQQ precursor peptide PqqA; This model describes a very small protein, coenzyme PQQ biosynthesis protein A, which is smaller than 25 amino acids in many species. It is proposed to serve as a peptide precursor of coenzyme pyrrolo-quinoline-quinone (PQQ), with Glu and Tyr of a conserved motif Glu-Xxx-Xxx-Xxx-Tyr becoming part of the product. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 273976  Cd Length: 21  Bit Score: 41.82  E-value: 4.28e-08
                         10        20
                 ....*....|....*....|.
gi 15597181    2 WTKPSFTDLRLGFEVTLYFAN 22
Cdd:TIGR02107  1 WKKPKFTEIRLGMEVTMYVSA 21
PqqA pfam08042
PqqA family; This family consists of proteins belonging to the coenzyme Pyrroloquinoline ...
 1-19 3.52e-07

PqqA family; This family consists of proteins belonging to the coenzyme Pyrroloquinoline quinone A (pqqA) family. PQQ is the non-covalently bounded prosthetic group of many quinoproteins catalysing reactions in the periplasm of Gram-negative bacteria. PQQ is formed by the fusion of glutamate and tyrosine and synthesis of PQQ require the proteins encoded by the pqqABCDEF operon but details of the biosynthetic pathway are unclear.


Pssm-ID: 429799  Cd Length: 19  Bit Score: 39.37  E-value: 3.52e-07
                         10
                 ....*....|....*....
gi 15597181    1 MWTKPSFTDLRLGFEVTLY 19
Cdd:pfam08042  1 AWTKPDFVEIRVGMEVTMY 19
 
Name Accession Description Interval E-value
pqqA PRK00284
pyrroloquinoline quinone precursor peptide PqqA;
1-23 5.09e-10

pyrroloquinoline quinone precursor peptide PqqA;


Pssm-ID: 178960  Cd Length: 23  Bit Score: 46.45  E-value: 5.09e-10
                        10        20
                ....*....|....*....|...
gi 15597181   1 MWTKPSFTDLRLGFEVTLYFANR 23
Cdd:PRK00284  1 AWTKPAYTELRVGMEVTMYFSAR 23
PQQ_syn_pqqA TIGR02107
coenzyme PQQ precursor peptide PqqA; This model describes a very small protein, coenzyme PQQ ...
 2-22 4.28e-08

coenzyme PQQ precursor peptide PqqA; This model describes a very small protein, coenzyme PQQ biosynthesis protein A, which is smaller than 25 amino acids in many species. It is proposed to serve as a peptide precursor of coenzyme pyrrolo-quinoline-quinone (PQQ), with Glu and Tyr of a conserved motif Glu-Xxx-Xxx-Xxx-Tyr becoming part of the product. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 273976  Cd Length: 21  Bit Score: 41.82  E-value: 4.28e-08
                         10        20
                 ....*....|....*....|.
gi 15597181    2 WTKPSFTDLRLGFEVTLYFAN 22
Cdd:TIGR02107  1 WKKPKFTEIRLGMEVTMYVSA 21
PqqA pfam08042
PqqA family; This family consists of proteins belonging to the coenzyme Pyrroloquinoline ...
 1-19 3.52e-07

PqqA family; This family consists of proteins belonging to the coenzyme Pyrroloquinoline quinone A (pqqA) family. PQQ is the non-covalently bounded prosthetic group of many quinoproteins catalysing reactions in the periplasm of Gram-negative bacteria. PQQ is formed by the fusion of glutamate and tyrosine and synthesis of PQQ require the proteins encoded by the pqqABCDEF operon but details of the biosynthetic pathway are unclear.


Pssm-ID: 429799  Cd Length: 19  Bit Score: 39.37  E-value: 3.52e-07
                         10
                 ....*....|....*....
gi 15597181    1 MWTKPSFTDLRLGFEVTLY 19
Cdd:pfam08042  1 AWTKPDFVEIRVGMEVTMY 19
PRK14763 PRK14763
pyrroloquinoline quinone precursor peptide PqqA;
1-23 3.48e-05

pyrroloquinoline quinone precursor peptide PqqA;


Pssm-ID: 184813  Cd Length: 23  Bit Score: 34.33  E-value: 3.48e-05
                        10        20
                ....*....|....*....|...
gi 15597181   1 MWTKPSFTDLRLGFEVTLYFANR 23
Cdd:PRK14763  1 MWTTPAATEMRFGFEVTMYVMNK 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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