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Conserved domains on  [gi|15598416|ref|NP_251910|]
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transcriptional regulator [Pseudomonas aeruginosa PAO1]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cupin_YobQ-like_N cd07003
Bacillus subtilis YobQ and related proteins, N-terminal cupin domain; This family includes ...
 8-73 1.43e-30

Bacillus subtilis YobQ and related proteins, N-terminal cupin domain; This family includes bacterial proteins homologous to Bacillus subtilis YobQ and Photobacterium leiognathi LumQ, both uncharacterized proteins thought to be DNA-binding proteins that may function as AraC/XylS family transcriptional regulators. YobQ has an N-terminal cupin beta barrel domain (represented by this alignment model) and a C-terminal AraC/XylS family helix-turn-helix (HTH) DNA-binding domain. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


:

Pssm-ID: 380407 [Multi-domain]  Cd Length: 66  Bit Score: 108.25  E-value: 1.43e-30
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15598416   8 RHYSHDQIVHSHDHAQLVLGLSGCLDFEVEGRGSRVLRQTFAVVPAQARHACSSPSGSRCLVLDLP 73
Cdd:cd07003   1 RTYSHDQSSHSHEHAQLVLPLSGSLELEVEGRGSRVKPDIGLYIPPNAEHRFAGSSDNRCLVLDLP 66
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
163-246 1.09e-26

helix_turn_helix, arabinose operon control protein;


:

Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 98.78  E-value: 1.09e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416    163 PLQVADLARLAGLSVARFHSLFLAETGQTPMDYARSRRLHQAHELLLESSLAVGEIAARVGYASQSAFTAALVREFGVTP 242
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 15598416    243 RQLR 246
Cdd:smart00342  81 SEYR 84
 
Name Accession Description Interval E-value
cupin_YobQ-like_N cd07003
Bacillus subtilis YobQ and related proteins, N-terminal cupin domain; This family includes ...
 8-73 1.43e-30

Bacillus subtilis YobQ and related proteins, N-terminal cupin domain; This family includes bacterial proteins homologous to Bacillus subtilis YobQ and Photobacterium leiognathi LumQ, both uncharacterized proteins thought to be DNA-binding proteins that may function as AraC/XylS family transcriptional regulators. YobQ has an N-terminal cupin beta barrel domain (represented by this alignment model) and a C-terminal AraC/XylS family helix-turn-helix (HTH) DNA-binding domain. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380407 [Multi-domain]  Cd Length: 66  Bit Score: 108.25  E-value: 1.43e-30
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15598416   8 RHYSHDQIVHSHDHAQLVLGLSGCLDFEVEGRGSRVLRQTFAVVPAQARHACSSPSGSRCLVLDLP 73
Cdd:cd07003   1 RTYSHDQSSHSHEHAQLVLPLSGSLELEVEGRGSRVKPDIGLYIPPNAEHRFAGSSDNRCLVLDLP 66
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
163-246 1.09e-26

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 98.78  E-value: 1.09e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416    163 PLQVADLARLAGLSVARFHSLFLAETGQTPMDYARSRRLHQAHELLLESSLAVGEIAARVGYASQSAFTAALVREFGVTP 242
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 15598416    243 RQLR 246
Cdd:smart00342  81 SEYR 84
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 136-250 1.17e-24

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 99.85  E-value: 1.17e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416 136 SERQPPRQQPRLPLASLDAYLDRHAAHPLQVADLARLAGLSVARFHSLFLAETGQTPMDYARSRRLHQAHELLLESSLAV 215
Cdd:COG4977 199 SPLLVPLGHRDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSI 278

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15598416 216 GEIAARVGYASQSAFTAALVREFGVTPRQLRRESR 250
Cdd:COG4977 279 EEIAAACGFGSASHFRRAFRRRFGVSPSAYRRRFR 313
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
3-252 4.42e-23

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 94.46  E-value: 4.42e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416   3 SILSLRHYSHDQIVHSHDHAQLVLGLSGCLDFEVEGRGSRVLRQTFAVVPAQARHACSSPSGSRCLVLDLPCDGSLLLGL 82
Cdd:COG2207  11 LLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416  83 GEHAEAGRRLFERPQALSLTPAQGQLVNWLASGPINDPVIAHQGAGLLLASLASERQpprQQPRLPLASLDAYLDRHAAH 162
Cdd:COG2207  91 LVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLL---LLLLLLLLLLLLLLLLLLLL 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416 163 PLQVADLARLAGLSVARFHSLFLAETGQTPMDYARSRRLHQAHELLLESSLAVGEIAARVGYASQSAFTAALVREFGVTP 242
Cdd:COG2207 168 LLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTP 247

                       250
                ....*....|
gi 15598416 243 RQLRRESRDK 252
Cdd:COG2207 248 SEYRKRLRAR 257
HTH_18 pfam12833
Helix-turn-helix domain;
169-247 2.12e-21

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 84.95  E-value: 2.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416   169 LARLAGLSVARFHSLFLAETGQTPMDYARSRRLHQAHELLLE-SSLAVGEIAARVGYASQSAFTAALVREFGVTPRQLRR 247
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEdTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80
ftrA PRK09393
transcriptional activator FtrA; Provisional
 140-250 7.02e-13

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 66.91  E-value: 7.02e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416  140 PPRQQPRLPLASLDAYLDRHAAHPLQVADLARLAGLSVARFHSLFLAETGQTPMDYARSRRLHQAHELLLESSLAVGEIA 219
Cdd:PRK09393 211 PVASRESDRLGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSALSIDQIA 290

                         90       100       110
                 ....*....|....*....|....*....|.
gi 15598416  220 ARVGYASQSAFTAALVREFGVTPRQLRRESR 250
Cdd:PRK09393 291 ERAGFGSEESLRHHFRRRAATSPAAYRKRFG 321
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
17-252 2.97e-09

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 56.22  E-value: 2.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416   17 HSHDHAQLVLGLSGCLDFEVEGRGSRVLRQTFAVVPAQARHACSSPSGsrcLVLD--LPCDGSLLLGLGEHAE----AGR 90
Cdd:PRK13502  34 HTHEFCELVMVWRGNGLHVLNERPYRITRGDLFYIRAEDKHSYTSVND---LVLQniIYCPERLKLNVNWQAMipgfQGA 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416   91 RLFERPQALSLTPAQG-QLVNWLASGPINDPVIAHQGAGLLLASLASERQPPR-QQPRLPLASLDAYLDR-------HAA 161
Cdd:PRK13502 111 QWHPHWRLGSMGMNQArQVINQLEHESNGRDPLANEMAELLFGQLVMTLKRHRyATDDLPATSRETLLDKlitalanSLE 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416  162 HPLQVADLARLAGLSVARFHSLFLAETGQTPMDYARSRRLHQAHELLLESSLAVGEIAARVGYASQSAFTAALVREFGVT 241
Cdd:PRK13502 191 CPFALDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVFTRETGMT 270

                        250
                 ....*....|.
gi 15598416  242 PRQLRRESRDK 252
Cdd:PRK13502 271 PSQWRHLSNQS 281
 
Name Accession Description Interval E-value
cupin_YobQ-like_N cd07003
Bacillus subtilis YobQ and related proteins, N-terminal cupin domain; This family includes ...
 8-73 1.43e-30

Bacillus subtilis YobQ and related proteins, N-terminal cupin domain; This family includes bacterial proteins homologous to Bacillus subtilis YobQ and Photobacterium leiognathi LumQ, both uncharacterized proteins thought to be DNA-binding proteins that may function as AraC/XylS family transcriptional regulators. YobQ has an N-terminal cupin beta barrel domain (represented by this alignment model) and a C-terminal AraC/XylS family helix-turn-helix (HTH) DNA-binding domain. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380407 [Multi-domain]  Cd Length: 66  Bit Score: 108.25  E-value: 1.43e-30
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15598416   8 RHYSHDQIVHSHDHAQLVLGLSGCLDFEVEGRGSRVLRQTFAVVPAQARHACSSPSGSRCLVLDLP 73
Cdd:cd07003   1 RTYSHDQSSHSHEHAQLVLPLSGSLELEVEGRGSRVKPDIGLYIPPNAEHRFAGSSDNRCLVLDLP 66
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
163-246 1.09e-26

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 98.78  E-value: 1.09e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416    163 PLQVADLARLAGLSVARFHSLFLAETGQTPMDYARSRRLHQAHELLLESSLAVGEIAARVGYASQSAFTAALVREFGVTP 242
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 15598416    243 RQLR 246
Cdd:smart00342  81 SEYR 84
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 136-250 1.17e-24

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 99.85  E-value: 1.17e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416 136 SERQPPRQQPRLPLASLDAYLDRHAAHPLQVADLARLAGLSVARFHSLFLAETGQTPMDYARSRRLHQAHELLLESSLAV 215
Cdd:COG4977 199 SPLLVPLGHRDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSI 278

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15598416 216 GEIAARVGYASQSAFTAALVREFGVTPRQLRRESR 250
Cdd:COG4977 279 EEIAAACGFGSASHFRRAFRRRFGVSPSAYRRRFR 313
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
3-252 4.42e-23

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 94.46  E-value: 4.42e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416   3 SILSLRHYSHDQIVHSHDHAQLVLGLSGCLDFEVEGRGSRVLRQTFAVVPAQARHACSSPSGSRCLVLDLPCDGSLLLGL 82
Cdd:COG2207  11 LLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416  83 GEHAEAGRRLFERPQALSLTPAQGQLVNWLASGPINDPVIAHQGAGLLLASLASERQpprQQPRLPLASLDAYLDRHAAH 162
Cdd:COG2207  91 LVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLL---LLLLLLLLLLLLLLLLLLLL 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416 163 PLQVADLARLAGLSVARFHSLFLAETGQTPMDYARSRRLHQAHELLLESSLAVGEIAARVGYASQSAFTAALVREFGVTP 242
Cdd:COG2207 168 LLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTP 247

                       250
                ....*....|
gi 15598416 243 RQLRRESRDK 252
Cdd:COG2207 248 SEYRKRLRAR 257
HTH_18 pfam12833
Helix-turn-helix domain;
169-247 2.12e-21

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 84.95  E-value: 2.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416   169 LARLAGLSVARFHSLFLAETGQTPMDYARSRRLHQAHELLLE-SSLAVGEIAARVGYASQSAFTAALVREFGVTPRQLRR 247
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEdTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 139-253 2.30e-20

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 88.57  E-value: 2.30e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416 139 QPPRQQPRLPL-ASLDAYLDRHAAHPLQVADLARLAGLSVARFHSLFLAETGQTPMDYARSRRLHQAHElLLESSLAVGE 217
Cdd:COG2169  75 LAPGSPPRADLvARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQ-LLQTGLSVTD 153

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 15598416 218 IAARVGYASQSAFTAALVREFGVTPRQLRRESRDKT 253
Cdd:COG2169 154 AAYAAGFGSLSRFYEAFKKLLGMTPSAYRRGGAGAA 189
ftrA PRK09393
transcriptional activator FtrA; Provisional
 140-250 7.02e-13

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 66.91  E-value: 7.02e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416  140 PPRQQPRLPLASLDAYLDRHAAHPLQVADLARLAGLSVARFHSLFLAETGQTPMDYARSRRLHQAHELLLESSLAVGEIA 219
Cdd:PRK09393 211 PVASRESDRLGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSALSIDQIA 290

                         90       100       110
                 ....*....|....*....|....*....|.
gi 15598416  220 ARVGYASQSAFTAALVREFGVTPRQLRRESR 250
Cdd:PRK09393 291 ERAGFGSEESLRHHFRRRAATSPAAYRKRFG 321
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
151-246 1.66e-11

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 59.55  E-value: 1.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416  151 SLDAYLDRHAAHPLQVADLARLAGLSVARFHSLFLAETGQTPMDYARSRRLHQAHELLLESSLAVGEIAARVGYASQSAF 230
Cdd:PRK10219   9 TLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTF 88

                         90
                 ....*....|....*.
gi 15598416  231 TAALVREFGVTPRQLR 246
Cdd:PRK10219  89 SRVFRRQFDRTPSDYR 104
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
17-252 2.97e-09

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 56.22  E-value: 2.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416   17 HSHDHAQLVLGLSGCLDFEVEGRGSRVLRQTFAVVPAQARHACSSPSGsrcLVLD--LPCDGSLLLGLGEHAE----AGR 90
Cdd:PRK13502  34 HTHEFCELVMVWRGNGLHVLNERPYRITRGDLFYIRAEDKHSYTSVND---LVLQniIYCPERLKLNVNWQAMipgfQGA 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416   91 RLFERPQALSLTPAQG-QLVNWLASGPINDPVIAHQGAGLLLASLASERQPPR-QQPRLPLASLDAYLDR-------HAA 161
Cdd:PRK13502 111 QWHPHWRLGSMGMNQArQVINQLEHESNGRDPLANEMAELLFGQLVMTLKRHRyATDDLPATSRETLLDKlitalanSLE 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416  162 HPLQVADLARLAGLSVARFHSLFLAETGQTPMDYARSRRLHQAHELLLESSLAVGEIAARVGYASQSAFTAALVREFGVT 241
Cdd:PRK13502 191 CPFALDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVFTRETGMT 270

                        250
                 ....*....|.
gi 15598416  242 PRQLRRESRDK 252
Cdd:PRK13502 271 PSQWRHLSNQS 281
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
140-248 3.65e-09

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 56.07  E-value: 3.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416  140 PPRQQPRLPLASLDAYLDRhaahPLQVADLARLAGLSVARFHSLFLAETGQTPMDYARSRRLHQAHELLLESSLAVGEIA 219
Cdd:PRK13501 173 PDGEQLDLIMSALQQSLGA----YFDMADFCHKNQLVERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHRISDIA 248

                         90       100
                 ....*....|....*....|....*....
gi 15598416  220 ARVGYASQSAFTAALVREFGVTPRQLRRE 248
Cdd:PRK13501 249 ARCGFEDSNYFSAVFTREAGMTPRDYRQR 277
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
142-252 5.38e-08

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 52.67  E-value: 5.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416  142 RQQPRLPLASLDA-------YLDRHAAHPLQVADLARLAGLSVARFHSLFLAETGQTPMDYARSRRLHQAHELLLESSLA 214
Cdd:PRK10572 171 EAIPESLHPPMDPrvreacqYISDHLASEFDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQTTRMP 250

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 15598416  215 VGEIAARVGYASQSAFTAALVREFGVTPRQLRRESRDK 252
Cdd:PRK10572 251 IATIGRNVGYDDQLYFSRVFKKCTGASPSEFRARCEEK 288
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
142-246 4.28e-07

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 47.79  E-value: 4.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416  142 RQQPRLPLASLDAYLDRHAAHPLQVADLARLAGLSVARFHSLFLAETGQTPMDYARSRRLHQAHELLLESSLAVGEIAAR 221
Cdd:PRK11511   4 RNTDAITIHSILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAER 83

                         90       100
                 ....*....|....*....|....*
gi 15598416  222 VGYASQSAFTAALVREFGVTPRQLR 246
Cdd:PRK11511  84 YGFESQQTLTRTFKNYFDVPPHKYR 108
PRK15121 PRK15121
MDR efflux pump AcrAB transcriptional activator RobA;
152-249 3.75e-06

MDR efflux pump AcrAB transcriptional activator RobA;


Pssm-ID: 185076 [Multi-domain]  Cd Length: 289  Bit Score: 46.93  E-value: 3.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416  152 LDAYLDRHAAHPLQVADLARLAGLSVARFHSLFLAETGQTPMDYARSRRLHQAHELLLESSLAVGEIAARVGYASQSAFT 231
Cdd:PRK15121  10 LLIWLEGHLDQPLSLDNVAAKAGYSKWHLQRMFKDVTGHAIGAYIRARRLSKAAVALRLTSRPILDIALQYRFDSQQTFT 89

                         90
                 ....*....|....*...
gi 15598416  232 AALVREFGVTPRQLRRES 249
Cdd:PRK15121  90 RAFKKQFAQTPALYRRSP 107
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
149-246 3.77e-06

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 46.98  E-value: 3.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416  149 LASLDAYLDRHAAHPLQVADLARLAGLSVARFHSLFLAETGQTPMDYARSRRLHQAHELLLESSLAVGEIAARVGYASQS 228
Cdd:PRK13503 173 LNQLLAWLEDHFAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRHSDASVTDIAYRCGFGDSN 252

                         90
                 ....*....|....*...
gi 15598416  229 AFTAALVREFGVTPRQLR 246
Cdd:PRK13503 253 HFSTLFRREFSWSPRDIR 270
PRK10371 PRK10371
transcriptional regulator MelR;
155-252 1.97e-05

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 44.81  E-value: 1.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416  155 YLDRHAAHPLQVADLARLAGLSVARFHSLFLAETGQTPMDYARSRRLHQAHELLLESSLAVGEIAARVGYASQSAFTAAL 234
Cdd:PRK10371 199 FIAENYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTDKSILDIALTAGFRSSSRFYSTF 278

                         90
                 ....*....|....*...
gi 15598416  235 VREFGVTPRQLRRESRDK 252
Cdd:PRK10371 279 GKYVGMSPQQYRKLSQQR 296
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 156-195 2.49e-05

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 40.60  E-value: 2.49e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 15598416   156 LDRHAAHPLQVADLARLAGLSVARFHSLFLAETGQTPMDY 195
Cdd:pfam00165   1 LRENLSTNLTIADIADELGFSRSYFSRLFKKYTGVTPSQY 40
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
17-72 4.96e-04

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 38.29  E-value: 4.96e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15598416  17 HSHDHAQLVLGLSGCLDFEVEGRGSRVLRQTFAVVPAQARHACSSPSGSRCLVLDL 72
Cdd:COG1917  39 HSHPGEELIYVLEGEGEVEVGGEEYELKPGDVVFIPPGVPHAFRNLGDEPAVLLVV 94
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 211-247 6.23e-04

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 36.75  E-value: 6.23e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 15598416   211 SSLAVGEIAARVGYaSQSAFTAALVREFGVTPRQLRR 247
Cdd:pfam00165   7 TNLTIADIADELGF-SRSYFSRLFKKYTGVTPSQYRH 42
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 185-242 9.15e-04

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 39.98  E-value: 9.15e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 15598416  185 LAETGQTPMDYARSRRLHQAHELLLESSLAVGEIAARVGYASQSAFTAALVREFGVTP 242
Cdd:PRK15185 243 LAEEGTSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTP 300
cupin_BacB_N cd20307
Bacillus subtilis bacilysin and related proteins, N-terminal cupin domain; This model ...
 17-72 1.61e-03

Bacillus subtilis bacilysin and related proteins, N-terminal cupin domain; This model represents the N-terminal domain of bacilysin (BacB, also known as AerE in Microcystis aeruginosa), a non-ribosomally synthesized dipeptide antibiotic that is produced and excreted by certain strains of Bacillus subtilis. Bacilysin is an oxidase that catalyzes the synthesis of 2-oxo-3-(4-oxocyclohexa-2,5-dienyl)propanoic acid, a precursor to L-anticapsin. Each bacilysin monomer has two tandem cupin domains. It is active against a wide range of bacteria and some fungi. The antimicrobial activity of bacilysin is antagonized by glucosamine and N-acetyl glucosamine, indicating that bacilysin interferes with glucosamine synthesis, and thus, with the synthesis of microbial cell walls. AerE is thought to be involved in the formation of the 2-carboxy-6-hydroxyoctahydroindole (Choi) moiety found on all aeruginosin tetrapeptides, based on gene knock-out experiments. It is encoded by the aerE gene of the aerABCDEF Aeruginosin biosynthesis gene cluster in Microcystis aeruginosa. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380441 [Multi-domain]  Cd Length: 100  Bit Score: 36.86  E-value: 1.61e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15598416  17 HSHDHAQLVLGLSGCLDFEVEGRgSRVLR--QTFAVVPAQARHACSSPSGSRCLVLDL 72
Cdd:cd20307  40 HQHPESQIGMVLSGELEMNVGGV-KKVMEplQDVYVAPPNVPHGAVNPSSEEAVGLDI 96
PRK09940 PRK09940
transcriptional regulator YdeO; Provisional
 161-250 3.92e-03

transcriptional regulator YdeO; Provisional


Pssm-ID: 182157 [Multi-domain]  Cd Length: 253  Bit Score: 37.76  E-value: 3.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416  161 AHPLQVADLARLAGLSVARFHSLFLAETGQTPMDYARSRRLHQAHELLLESSlaVGEIAARVGYASQSAFTAALVREFGV 240
Cdd:PRK09940 148 AHPWKLKDICDCLYISESLLKKKLKQEQTTFSQILLDARMQHAKNLIRVEGS--VNKIAEQCGYASTSYFIYAFRKHFGN 225

                         90
                 ....*....|
gi 15598416  241 TPRQLRRESR 250
Cdd:PRK09940 226 SPKRVSKEYR 235
cupin_RmlC-like cd02208
RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP ...
 17-70 4.10e-03

RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP (deoxythymidine diphosphates)-4-dehydrorhamnose 3,5-epimerase)-like cupins. RmlC is a dTDP-sugar isomerase involved in the synthesis of L-rhamnose, a saccharide required for the virulence of some pathogenic bacteria. Cupins are a functionally diverse superfamily originally discovered based on the highly conserved motif found in germin and germin-like proteins. This conserved motif forms a beta-barrel fold found in all of the cupins, giving rise to the name cupin ('cupa' is the Latin term for small barrel). The active site of members of this superfamily is generally located at the center of a conserved barrel and usually includes a metal ion. The different functional classes in this superfamily include single domain bacterial isomerases and epimerases involved in the modification of cell wall carbohydrates, two domain bicupins such as the desiccation-tolerant seed storage globulins, and multidomain nuclear transcription factors involved in legume root nodulation.


Pssm-ID: 380338 [Multi-domain]  Cd Length: 73  Bit Score: 35.15  E-value: 4.10e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15598416  17 HSHDHA-QLVLGLSGCLDFEVEGRGSRVLRQ-TFAVVPAQARHACSSPSGSRCLVL 70
Cdd:cd02208  15 HWHPEQdEIFYVLSGEGELTLDDGETVELKAgDIVLIPPGVPHSFVNTSDEPAVFL 70
cupin_NimR-like_N cd06124
AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This ...
 17-103 6.51e-03

AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380379 [Multi-domain]  Cd Length: 95  Bit Score: 35.24  E-value: 6.51e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598416  17 HSHDHAQLVLGLSGCLDFEVEgRGSRVLRQTFAV-VPAQARHACSSPSG--SRCLVLDlpcdgslllglgehAEAGRRLF 93
Cdd:cd06124  17 HSHPWGQLLYASSGVMTVETE-DGRWLVPPQRAVwIPAGVEHSVRMLGAveLRSLYID--------------PEAAAGLP 81

                        90
                ....*....|
gi 15598416  94 ERPQALSLTP 103
Cdd:cd06124  82 AEPCVLAVSP 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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