|
Name |
Accession |
Description |
Interval |
E-value |
| actP |
PRK09395 |
cation/acetate symporter ActP; |
1-551 |
0e+00 |
|
cation/acetate symporter ActP;
Pssm-ID: 236495 Cd Length: 551 Bit Score: 994.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 1 MIARLLAALGLAAFAPALWADALTGDVQRQPLNVSAIVMFVAFVGATLCITYWASKRNRSAADYYAAGGRITGFQNGLAI 80
Cdd:PRK09395 1 MMKRLLTALAALLPAAAAAADAISGEVEKQPTNWQAIIMFLIFVVFTLGITYWAAKRTRSASDFYTAGGGITGFQNGLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 81 AGDYMSAASFLGISALVFTSGYDGLIYSIGFLVGWPIILFLIAERLRNLGKYTFADVASYRLKQKQIRTLSACGSLVVVA 160
Cdd:PRK09395 81 AGDYMSAASFLGISALVFTSGYDGLIYSIGFLVGWPIILFLIAERLRNLGKYTFADVASYRLKQGPIRTLSACGSLVVVA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 161 FYLIAQMVGAGKLIELLFGLNYHVAVVLVGILMVLYVLFGGMLATTWVQIIKAVLLLSGASFMAIMVLKHVNFDVSTLFS 240
Cdd:PRK09395 161 LYLIAQMVGAGKLIQLLFGLNYHVAVVLVGVLMMVYVLFGGMLATTWVQIIKAVLLLSGATFMAFMVMKHVGFSFENLFS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 241 EAIKVHPKGEAIMSPGGLVKDPISAFSLGFALMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGA 320
Cdd:PRK09395 241 EAVAVHPKGLAIMGPGGLVKDPISALSLGLALMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 321 ILLVSTNPDFKDATGALIGGNNMAAVHLADAVGGSLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVFKGGKANE 400
Cdd:PRK09395 321 IVLVGTNPEFKDAAGALIGGNNMAAVHLANAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVIKKGKATE 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 401 KDELRVSKMTTVALGVVAIVLGILFEKQNIAFMVGLAFSIAASCNFPVLLLSMYWKKLTTRGAMIGGWMGLITAVGLMVL 480
Cdd:PRK09395 401 RDELRVSKITTLVLGVVAIILGILFEKQNIAFMVGLAFAIAASANFPVLLLSMYWKGLTTRGAVIGGWLGLISAVVLMIL 480
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15598430 481 GPTIWVQILGHEKAIYPYEYPALFSMIVAFVGIWFFSITDKSAAADEERARFFPQFIRSQTGLGASGAVAH 551
Cdd:PRK09395 481 SPTVWVDILGHEKAIFPYEYPALFSMPLAFVGIWFFSITDNSARAKREREAFRAQFVRSQTGIGASGASAH 551
|
|
| symport_actP |
TIGR02711 |
cation/acetate symporter ActP; Members of this family belong to the Sodium:solute symporter ... |
20-551 |
0e+00 |
|
cation/acetate symporter ActP; Members of this family belong to the Sodium:solute symporter family. Both members of this family and other close homologs tend to be encoded next to a member of pfam04341, a set of uncharacterized membrane proteins. The characterized member from E. coli is encoded near and cotranscribed with the acetyl coenzyme A synthetase (acs) gene. Proximity to an acs gene was used as one criterion for determining the trusted cutoff for this model. Closely related proteins may differ in function and are excluded by the high cutoffs of this model; members of the family of phenylacetic acid transporter PhaJ can score as high as 1011 bits. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 131758 Cd Length: 549 Bit Score: 878.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 20 ADALTGDVQRQPLNVSAIVMFVAFVGATLCITYWASKRNRSAADYYAAGGRITGFQNGLAIAGDYMSAASFLGISALVFT 99
Cdd:TIGR02711 18 ADAISGAVERQPLNIQAIIMFLLFVGFTLYITYWASKKTRSRSDYYTAGGNITGFQNGLAIAGDYMSAASFLGISALVYT 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 100 SGYDGLIYSIGFLVGWPIILFLIAERLRNLGKYTFADVASYRLKQKQIRTLSACGSLVVVAFYLIAQMVGAGKLIELLFG 179
Cdd:TIGR02711 98 SGYDGLIYSLGFLVGWPIILFLIAERLRNLGRYTFADVASYRLKQRPIRILSACGSLVVVALYLIAQMVGAGKLIELLFG 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 180 LNYHVAVVLVGILMVLYVLFGGMLATTWVQIIKAVLLLSGASFMAIMVLKHVNFDVSTLFSEAIKVHPKGEAIMSPGGLV 259
Cdd:TIGR02711 178 LNYHVAVVLVGILMVMYVLFGGMLATTWVQIIKAVLLLFGATFMAFMVMKSVGFSFNTLFKEAMAVHPKGVAIMSPGGLV 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 260 KDPISAFSLGFALMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAILLVSTNPDFKDATGALIG 339
Cdd:TIGR02711 258 SDPISALSLGLGLMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFMGYFYILTFIIGFGAILLVSANPEFKDATGALIG 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 340 GNNMAAVHLADAVGGSLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVFKGGKANEKDELRVSKMTTVALGVVAI 419
Cdd:TIGR02711 338 GNNMAAVHLANAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVIKKGKATERDELRVSKITVLILGVIAI 417
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 420 VLGILFEKQNIAFMVGLAFSIAASCNFPVLLLSMYWKKLTTRGAMIGGWMGLITAVGLMVLGPTIWVQILGHEKAIYPYE 499
Cdd:TIGR02711 418 GLGILFENQNIAFMVGLAFSIAASCNFPIILLSMYWSKLTTRGAMIGGWLGLITAVVLMILGPTIWVQILGHEKPIYPYE 497
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 15598430 500 YPALFSMIVAFVGIWFFSITDKSAAADEERARFFPQFIRSQTGLGASGAVAH 551
Cdd:TIGR02711 498 YPALFSMIVAFIGIWFFSITDNSETGAQERELFRAQFIRSQTGLGASQGRAH 549
|
|
| PRK12488 |
PRK12488 |
cation/acetate symporter; |
20-551 |
0e+00 |
|
cation/acetate symporter;
Pssm-ID: 237114 [Multi-domain] Cd Length: 549 Bit Score: 770.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 20 ADALTGDVQRQPLNVSAIVMFVAFVGATLCITYWASKRNRSAADYYAAGGRITGFQNGLAIAGDYMSAASFLGISALVFT 99
Cdd:PRK12488 18 ASPALDAGQRQPLNWTAIGMFMVFVLFTLGITRWAARRTRSASDFYTAGGGLTGMQNGLAIAGDMISAASFLGISAMMFM 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 100 SGYDGLIYSIGFLVGWPIILFLIAERLRNLGKYTFADVASYRLKQKQIRTLSACGSLVVVAFYLIAQMVGAGKLIELLFG 179
Cdd:PRK12488 98 NGYDGLLYALGVLAGWPIILFLIAERLRNLGKYTFADVVSYRLAQGPVRLTAAFGTLTVVLMYLVAQMVGAGKLIELLFG 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 180 LNYHVAVVLVGILMVLYVLFGGMLATTWVQIIKAVLLLSGASFMAIMVLKHVNFDVSTLFSEAIKVHPKGEAIMSPGGLV 259
Cdd:PRK12488 178 ISYLYAVVIVGALMVLYVTFGGMLATTWVQIIKAVLLLSGTSFMAFMVLKHFGFSTEAMFASAVAVHAKGQAILAPGGLL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 260 KDPISAFSLGFALMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAILLVSTNPDFKDATGALIG 339
Cdd:PRK12488 258 SNPIDAISLGLGMMFGTAGLPHILMRFFTVSDAREARKSVLYATGFIGYFYLLIIVVGFGAIVMVGTEPSYRDAGGKIIG 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 340 GNNMAAVHLADAVGGSLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVFKGGKANEKDELRVSKMTTVALGVVAI 419
Cdd:PRK12488 338 GGNMVAVHLAQAVGGNLFLGFISAVAFATILAVVAGLALSGASAVSHDLYACVIRKGQASEAQEMRVSKIATLGIGLLAV 417
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 420 VLGILFEKQNIAFMVGLAFSIAASCNFPVLLLSMYWKKLTTRGAMIGGWMGLITAVGLMVLGPTIWVQILGHEKAIYPYE 499
Cdd:PRK12488 418 VLGLMFESQNIAFLSGLVLAIAASVNFPVLFLSMFWKGLTTRGAVAGSYAGLVSAVVLVVLGPAVWVNVLHNATALFPYS 497
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 15598430 500 YPALFSMIVAFVGIWFFSITDKSAAADEERARFFPQFIRSQTGLGASGAVAH 551
Cdd:PRK12488 498 NPALFSMSLAFLSAWVFSVTDRSERAVAERGRYLAQFVRSMTGIGAAGASKH 549
|
|
| ActP |
COG4147 |
Na+(or H+)/acetate symporter ActP [Energy production and conversion]; |
25-549 |
0e+00 |
|
Na+(or H+)/acetate symporter ActP [Energy production and conversion];
Pssm-ID: 443318 Cd Length: 526 Bit Score: 721.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 25 GDVQRQPLNVSAIVMFVAFVGATLCITYWASKRNRSAADYYAAGGRITGFQNGLAIAGDYMSAASFLGISALVFTSGYDG 104
Cdd:COG4147 3 ALLEQLGMNLLAIGIFLVFVTFTLYITIWAARRTKSTSDFYVAGRGVTGVQNGLAIAGDYMSAASFLGIAGLIALSGYDG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 105 LIYSIGFLVGWPIILFLIAERLRNLGKYTFADVASYRLKQKQIRTLSACGSLVVVAFYLIAQMVGAGKLIELLFGLNYHV 184
Cdd:COG4147 83 LIYSIGWLVGYVLLLLLLAEYLRNFGKFTVPDFLGDRFYSRPARLVAAISTLVVSFFYLIAQMVGAGVLISLLLGVDYEV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 185 AVVLVGILMVLYVLFGGMLATTWVQIIKAVLLLSGASFMAIMVLKHVNFDVSTLFSEAIKVHPKGEAIMSPGGLVKDPIS 264
Cdd:COG4147 163 AVVIVGVLMIVYVVLGGMKGTTWVQIIKAVLLIFAYTVPAVLVLAQFGFNPLPLLAKAAEVHDLGAAYLEPGGLVKSPLD 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 265 AFSLGFALMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAILLVSTNPDFKDAT--GALIGGNN 342
Cdd:COG4147 243 FISLGLALMLGTAGLPHILMRFFTVPDAKEARKSVGWALGFIGLFYLTAPALGFGARALVGPLPEWFDTGliGAADGGGN 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 343 MAAVHLADAV-GGSLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVFKgGKANEKDELRVSKMTTVALGVVAIVL 421
Cdd:COG4147 323 MAVLALAEIAgGGNWLLGLVAAGAFATILAVVAGLLLAIASAISHDLYANVIK-GKATEKEELRVARIAAVVIGVVAILL 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 422 GILFEKQNIAFMVGLAFSIAASCNFPVLLLSMYWKKLTTRGAMIGGWMGLITAVGLMVLGPTIWVqiLGHEKAIYPYEYP 501
Cdd:COG4147 402 GINAPPQNVAFLVALAFALAASANFPVLLLSIFWKRFNTRGAVAGMLVGLISALVLIVLSPFVWV--LGVDAALFPLENP 479
|
490 500 510 520
....*....|....*....|....*....|....*....|....*...
gi 15598430 502 ALFSMIVAFVGIWFFSITDKSAAAdEERARFFPQFIRSQTGLGASGAV 549
Cdd:COG4147 480 GLVSMPLGFLVAIVVSLLTPEPPA-EDQELVEEQEVRSPTGIGAAKAS 526
|
|
| SLC5sbd_u4 |
cd11480 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
37-519 |
0e+00 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271374 Cd Length: 488 Bit Score: 577.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 37 IVMFVAFVGATLCITYWASKRNRSAADYYAAGGRITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSIGFLVGWP 116
Cdd:cd11480 1 IGLFFVFVTITLYITIWAARRTRSTSDFYVAGRGVPPVQNGLAIAGDYMSAASFLGIAGLIALSGYDGLAYAIGWTGGYV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 117 IILFLIAERLRNLGKYTFADVASYRLKQKQIRTLSACGSLVVVAFYLIAQMVGAGKLIELLFGLNYHVAVVLVGILMVLY 196
Cdd:cd11480 81 LLLLLVAEPLRNFGKYTVPDFLGARLGSRPVRLVAAVSTLVISFFYLVAQMVGAGLLLSLLLGIPYEVGVVVVGALMIVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 197 VLFGGMLATTWVQIIKAVLLLSGASFMAIMVLKHVNF-----DVSTLFSEAIKVHPKGEAIMSPGGLVKDPISAFSLGFA 271
Cdd:cd11480 161 VVLGGMRATTWVQIIQYVLLLGAFLVPAILVLARFGGnplgaGPGLLGLAAAAASGAGEAYLAPGLLLTDPLDVISLTLA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 272 LMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAILLVSTNPDFKDATGALIGGNNMAAVHLADA 351
Cdd:cd11480 241 LMLGTAGLPHVLMRFYTVPDARAARKSVVWALGFIGLFYLLAPALGFGARALVGPDVIGAPIAGELDGGGDMAVLLLPEI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 352 VG-GSLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVFKGGkANEKDELRVSKMTTVALGVVAIVLGILFEKQNI 430
Cdd:cd11480 321 AGlGDLLLALVAAGAFAAILATVAGLLLAAASALAHDLYAGVIRPG-ASERREVRVARIAAVVVGVIAILLALLFPPQNV 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 431 AFMVGLAFSIAASCNFPVLLLSMYWKKLTTRGAMIGGWMGLITAVGLMVLGPTIWVQILGHEKAIYPYEYPALFSMIVAF 510
Cdd:cd11480 400 AFLVALAFAIAASAFFPVLVLGIFWRRFTTRGAIAGMLVGLLVSLVLIVLSPAVSGAPPGHDFAGFPLTNPGLVSVPLGF 479
|
....*....
gi 15598430 511 VGIWFFSIT 519
Cdd:cd11480 480 LVAIVVSLL 488
|
|
| SSF |
pfam00474 |
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ... |
64-470 |
2.62e-128 |
|
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.
Pssm-ID: 109527 [Multi-domain] Cd Length: 406 Bit Score: 380.92 E-value: 2.62e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 64 YYAAGGRITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSIGFLVGWPIILFLIAERLRNLGKYTFADVASYRLK 143
Cdd:pfam00474 1 YFLAGRSMTGFVNGLSLAASYMSAASFVGLAGAGAASGLAGGLYAIGALVGVWLLLWLFAPRLRNLGAYTMPDYLRKRFG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 144 QKQI-RTLSACGSLVVVAFYLIAQMVGAGKLIELLFGLNYHVAVVLVGILMVLYVLFGGMLATTWVQIIKAVLLLSGASF 222
Cdd:pfam00474 81 GKRIlVYLSALSLLLYFFTYMSVQIVGGARLIELALGLNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVLMLFGTII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 223 MAIMVLKHVNfDVSTLFSEAIKVHPKGEAIMSPGGL--VKDPISAFSLGFALMFGTAGLPHILMRFFTVSDAKEARKSVF 300
Cdd:pfam00474 161 LMIIVFHEVG-GYSSAVEKYMTADPNGVDLYTPDGLhiLRDPLTGLSLWPGLVLGTTGLPHILQRCLAAKDAKCIRCGVL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 301 YATGFIGYFYILTFIIGFGAILLVSTNPDfkdATGALIGGNNMAAVHLADAVGGSLFLGFISAVAFATILAVVAGLTLAG 380
Cdd:pfam00474 240 ILTPMFIIVMPGMISRGLFAIALAGANPR---ACGTVVGCSNIAYPTLAVKLGPPGLAGIMLAVMLAAIMSTLTSQLLSS 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 381 ASAVSHDLYASVFKGGKANEKDELRVSKMTTVALGVVAIVLGILFEKQNIAFMVGLAFSIAASCNFPVLLLSMYWKKLTT 460
Cdd:pfam00474 317 SSAFTHDLYKNIRRKASATEKELVGRSRIIVLVVISLAILLAVQPAQMGIAFLVQLAFAGLGSAFLPVILLAIFWKRVNE 396
|
410
....*....|
gi 15598430 461 RGAMIGGWMG 470
Cdd:pfam00474 397 QGALWGMIIG 406
|
|
| PutP |
COG0591 |
Na+/proline symporter [Amino acid transport and metabolism]; |
32-530 |
5.13e-69 |
|
Na+/proline symporter [Amino acid transport and metabolism];
Pssm-ID: 440356 [Multi-domain] Cd Length: 476 Bit Score: 229.70 E-value: 5.13e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 32 LNVSAIVMFVAFVGATLCITYWASKRNRSAADYYAAGGRITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSIGF 111
Cdd:COG0591 1 MSTLDLIIIILYLLLLLGIGLYASRRTKSLEDYFLAGRSLGWWVLALSLGATWLSAWTFLGVPGLAYAYGLSALWYALGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 112 LVGWPIILFLIAERLRNLGKYTFADVASYRLKQKqIRTLSACGSLVVVAFYLIAQMVGAGKLIELLFGLNYHVAVVLVGI 191
Cdd:COG0591 81 ALGALLLALFFAPRLRRLGALTIPEFLEKRFGRG-LRLLAAIIILLFLLGYLAAQLVALGKLLEALFGIPYWLGILIGAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 192 LMVLYVLFGGMLATTWVQIIKAVLLLSGASFMAIMVLKHVNfDVSTLFSeaiKVHPKGEAIMSPGGLVKDPISAFSLGFA 271
Cdd:COG0591 160 IVLLYTVLGGLRAVAWTDVLQGILMLVGLILLLIVALSALG-GFGELFA---ALPAPGLLSLFPGLGFTGWLAFLGLFLA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 272 LMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAILLVSTNPdfkdatgalIGGNNMAAVHLADA 351
Cdd:COG0591 236 IGLGYFGQPHIVQRFLAAKSEKEARKAALIGGLLYLLFYLLAALIGLLARALFPDLP---------LADPDLALPLLILE 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 352 VGGSLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVFKgGKANEKDELRVSKMTTVALGVVAIVLGILFeKQNIA 431
Cdd:COG0591 307 LLPPGLAGLLLAAILAAAMSTADSQLLAASSVFTRDIYKPFIK-PKASDKQLLRVSRLAVLVVGLLALLLALLF-PSSIL 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 432 FMVGLAFSIAASCNFPVLLLSMYWKKLTTRGAMIGGWMGLITavglmvlgpTIWVQILGHEKAIYPYEYPALFSMIVAFV 511
Cdd:COG0591 385 DLVLLAWGGLGAALLPPLLLGLFWKRATKAGALAGMIAGLVV---------VLLWKLLGGPLGPFGWLYPILPGLLVSLL 455
|
490
....*....|....*....
gi 15598430 512 GIWFFSITDKSAAADEERA 530
Cdd:COG0591 456 VFVVVSLLTKPPSEEVLEE 474
|
|
| Na_symport_lg |
TIGR03648 |
probable sodium:solute symporter, VC_2705 subfamily; This family belongs to a larger family of ... |
43-480 |
7.08e-66 |
|
probable sodium:solute symporter, VC_2705 subfamily; This family belongs to a larger family of transporters of the sodium:solute symporter superfamily, TC 2.A.21. Members of this strictly bacterial protein subfamily are found almost invariably immediately downstream from a member of family TIGR03647. Occasionally, the two genes are fused.
Pssm-ID: 274698 Cd Length: 552 Bit Score: 223.67 E-value: 7.08e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 43 FVGAT----LCITYWAskRNRSAADYYAAGGRITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSIGFLVGWPII 118
Cdd:TIGR03648 4 FVGATfalyIGIGIWS--RAGSTSEFYVAGRGVPPVANGMATAADWMSAASFISMAGLIAFLGYDGLAYLMGWTGGYVLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 119 LFLIAERLRNLGKYTFADVASYRLKQKQIRTLSACGSLVVVAFYLIAQMVGAGKLIELLFGLNYHVAVVLVGILMVLYVL 198
Cdd:TIGR03648 82 ALLLAPYLRKFGKYTVPDFIGDRYYSNTARLVAVICAIFISFTYVAGQMRGVGVVFSRFLEVDFETGVFIGMAIVFFYAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 199 FGGMLATTWVQIIKAVLL----LSGASFMAIMVLKHV--NFDVSTLFSEAIKVHPKGE--------AIMSPGGlVKDPIS 264
Cdd:TIGR03648 162 LGGMKGVTWTQVAQYIVLivayLVPAIFISLKLTGNPvpQLGYGSALSGVYLLDKLDElevdlgfaEYTEPFG-SKSRIN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 265 AFSLGFALMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFIGYFY-------------ILTFIIG-------------- 317
Cdd:TIGR03648 241 VFALTLALMVGTAGLPHVIVRFYTVPKVRDARWSAGWALFFIALLYttapavaafarynLITTVNGtpyaelpgwvanwe 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 318 -FGAILLVSTNPD----FKDATGALIGGNNMAAVHLADAVGG--SLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYA 390
Cdd:TIGR03648 321 kTGLLKFEDKNGDgilqYSGDAGNELTIDRDIIVLATPEIAGlpYWVIGLVAAGGLAAALSTAAGLLLVISSAISHDLYY 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 391 SVFKgGKANEKDELRVSKMTTVALGVVAIVLGILfEKQNIAFMVGLAFSIAASCNFPVLLLSMYWKKLTTRGAMIGGWMG 470
Cdd:TIGR03648 401 RIIN-PNASEKQRLLVARIALVVAAVIAGYFGLN-PPGFIAQVVAFAFGLAAASFFPALVLGIFWKRMNREGAIAGMLTG 478
|
490
....*....|
gi 15598430 471 LITAVGLMVL 480
Cdd:TIGR03648 479 LGFTFSYIVY 488
|
|
| SLC5sbd |
cd10322 |
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ... |
37-517 |
6.74e-62 |
|
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.
Pssm-ID: 271357 [Multi-domain] Cd Length: 454 Bit Score: 210.49 E-value: 6.74e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 37 IVMFVAFVGATLCITYWASKRNRSAADYYAAGGRITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSIGFLVGWP 116
Cdd:cd10322 3 LIIVVVYLALLLGIGLYASKKVKSSEDFFLAGRSLGPWLLAGTLAATWISAGSFVGVAGLAYTYGLSAIWYILGAALGAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 117 IILFLIAERLRNLGKYTFADVASYRLKQKQIRTLSACGSLVVVAFYLIAQMVGAGKLIELLFGLNYHVAVVLVGILMVLY 196
Cdd:cd10322 83 LLALFLAPRLRRLGKTTIPETILERYYSKGLRLLVAIIIIIALIPYLALQLIGGGYILSTLLGIPYTVAVIIAAVIVILY 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 197 VLFGGMLATTWVQIIKAVLLLSGASFMAIMVLKHVNFDVSTLFSEAIKVHPKGEAIMSPGGlvkdPISAFSLGFALMFGT 276
Cdd:cd10322 163 TVFGGMRAVAWTDVIQGIVMLIGVLVAAIFILSKVGGGGFSALAAALPALLLALGPGGGLG----WSTILSLILLTGLGV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 277 AGLPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAILLVSTnpdfkdatgalIGGNNMAAVHLADAVGGSL 356
Cdd:cd10322 239 LALPQVFQRILAAKDEKTARRAFLLAGLLLLLIGFLVALIGLAARALFPD-----------LENPDLALPTLINSLLPPG 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 357 FLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVFKgGKANEKDELRVSKMTTVALGVVAIVLGILFekQNIAFMVGL 436
Cdd:cd10322 308 LAGLVLAGLLAAAMSTADSLLLAASTLFTRDIYKPLIN-PKASDKKLLRVSRIAVVVVGVLALLLALLP--PSILLLLSL 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 437 AFSIAASCNFPVLLLSMYWKKLTTRGAMIGGWMGLITAVGLMVLGPTIWVQIlghekaiypyeYPALFSMIVAFVGIWFF 516
Cdd:cd10322 385 AAGLLAAALFPPLLGGLFWKRATKAGAIAGIIVGLIVTLVWLLLPLASPLGI-----------DPIIPALLVSLIVFVVV 453
|
.
gi 15598430 517 S 517
Cdd:cd10322 454 S 454
|
|
| SLC5sbd_PutP |
cd11475 |
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli ... |
37-518 |
2.53e-61 |
|
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli PutP catalyzes the Na+-coupled uptake of proline with a stoichiometry of 1:1. The putP gene is part of the put operon; this operon in addition encodes a proline dehydrogenase, allowing the use of proline as a source of nitrogen and/or carbon. This subfamily also includes the Bacillus subtilis Na+/proline cotransporter (OpuE) which has an osmoprotective instead of catabolic role. Expression of the opuE gene is under osmotic control and different sigma factors contribute to its regulation; it is also a putative CcpA-activated gene. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271369 Cd Length: 464 Bit Score: 209.29 E-value: 2.53e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 37 IVMFVAFVGATLCITYWASKRNRSAADYYAAGGRITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSIGFLVGWP 116
Cdd:cd11475 1 LITFIVYLLLMLGIGIYSYRKTKTLEDYFLGGRSLGPWVTALSAGASDMSGWLLLGLPGAAYASGLSAIWIAIGLILGAY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 117 IILFLIAERLRNL----GKYTFADVASYRLKQK--QIRTLSACGSLVVVAFYLIAQMVGAGKLIELLFGLNYHVAVVLVG 190
Cdd:cd11475 81 LNWLFVAKRLRRYteknDSITLPDYLENRFRDKskLLRILSALIILIFFTIYAAAQLVAGGKLFESLFGIDYSTGLLIGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 191 ILMVLYVLFGGMLATTWVQIIKAVLLLSGASFMAIMVLKHVNfDVSTLFSEAIKVHPkGEAIMSPGGLVKDPISAFSLGF 270
Cdd:cd11475 161 VVVVAYTFLGGFLAVSWTDFFQGLLMLLALVLVPIVALAALG-GLSGLVAALAAIDP-GLLSPFGGDLGAGGLLAIISLL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 271 ALMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAILLVstnpdfkdaTGALIGGNNMAAVHLAD 350
Cdd:cd11475 239 AWGLGYFGQPHILVRFMAIRSPKEIKKARRIAMVWMILFLLGAVLVGLLGRALF---------PDGLLGDPETVFPVLAQ 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 351 AVGGSLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVFKgGKANEKDELRVSKMTTVALGVVAIVLGiLFEKQNI 430
Cdd:cd11475 310 ELFPPWLAGILLAAILAAIMSTADSQLLVCSSALTEDLYKAFLR-KEASDKELVWVSRLAVLVIALIALLIA-LNPPSSV 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 431 AFMVGLAFSIAASCNFPVLLLSMYWKKLTTRGAMIGGWMGLITAVglmvlgptIWVQILGHEKAIYPYeypaLFSMIVAF 510
Cdd:cd11475 388 FSLVSFAWAGLGAAFGPLLLLSLYWKRTTRQGALAGMIAGAVTVV--------VWKLLGLGIFGLYEI----VPGFLASL 455
|
....*...
gi 15598430 511 VGIWFFSI 518
Cdd:cd11475 456 LAIVVVSL 463
|
|
| sss |
TIGR00813 |
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ... |
67-466 |
2.94e-50 |
|
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273282 [Multi-domain] Cd Length: 407 Bit Score: 177.88 E-value: 2.94e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 67 AGGRITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSIGFLVGWPIILFLIAERLRNLGKYTFADVASYRLKQKQ 146
Cdd:TIGR00813 1 AGRSLGGWVVAASLFASYISASQFLGLPGAIYAYGFAIGFYELGALVLLIILGWLFVPIFINNGAYTMPEYLEKRFGKRI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 147 IRTLSACGSLVVVAFYLIAQMVGAGKLIELLFGLNYHVAVVLVGILMVLYVLFGGMLATTWVQIIKAVLLLSGASFMAIM 226
Cdd:TIGR00813 81 LRGLSVLSLILYIFLYMSVDLFSGALLIELITGLDLYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIMILGTFILPVF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 227 VLKHVNF--DVSTLFSEAIKVHPkgeaimSPGGLVKDPISAFSLGFALMFGTAGLPH----------ILMRFFTVSDAKE 294
Cdd:TIGR00813 161 AFSEVGGlgTFVEKASQAAPTNP------SPDDLYDFFRDPSTSDLPWGAGVFGLPHvalwywtnqvIVQRCLAAKSAKH 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 295 ARKSVFYATGFIGYFYILTFIIGFGAILLV-STNPdfkDATGALIGGNNMAAVHLADAVGGSLFLGFISAVAFATILAVV 373
Cdd:TIGR00813 235 AKKGCLISGVLKLLPMFGAVLPGLIARALYtDIDP---ALAGAVNQNSDQAYPLLVQELMPPGLAGLFLAAILAAVMSTL 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 374 AGLTLAGASAVSHDLYASVFKGGKANEKDELRVSKMTTVALGVVAIVLgILFEKQNIAFMVGLAFSIAASCNFPVLLLSM 453
Cdd:TIGR00813 312 SSQLNSASTVFTMDLYKKIIRPNASGEKKIVMRGRIAVLVAAVIAGFV-AAAQGGQVLQYVQEAFGGLGAPFLPVFLLGI 390
|
410
....*....|...
gi 15598430 454 YWKKLTTRGAMIG 466
Cdd:TIGR00813 391 FWKRMNAKGALAG 403
|
|
| SLC5sbd_u1 |
cd11477 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
37-511 |
1.91e-29 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271371 Cd Length: 493 Bit Score: 121.53 E-value: 1.91e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 37 IVMFVAFVGATLCITYWASKR-NRSAADYYAAGGRITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSIGFLVGW 115
Cdd:cd11477 3 WLVIALYFLLMLGIGLWFSKRaSKSTSDFFLGGRKLPWWLAGISMAATTFSADTFVAVAGIAYTYGIAGNWIWWLWAVAG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 116 PIILFLIAERLRNLGKYTfaDVASYRL--------KQKQIRTLSacGSLVVVAFYLIAQMVGAGKLIELLFGLNYHVAVV 187
Cdd:cd11477 83 LIGAFVFARRWRRLRVLT--DGEFPEEryggrygaPLRQFYAVY--FALLSNVDILAWVFLAAIKVSAVFGPWDPWLTIL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 188 LVGILMVLYVLFGGMLATTWVQIIKAVLLLSGASFMAIMVLKHVNFD---VSTLFSEAIKVHPKGEAIMSPGGLVKdpIS 264
Cdd:cd11477 159 ILGLITLIYTVIGGLWAVVVTDVVQFVIAMAASIAVAVLALNAVGGPgglFAQLPEGHLDLFGSGLGASGFYITFF--FI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 265 AFSLGFALMFGTAGlPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAILLvstNPDFKDatgaLIGGNNMA 344
Cdd:cd11477 237 LFFGWYPLSYSGGG-WYLAQRYLSAKSEKAAKAAAWLFAALYLVRPWPWMLPALAALVL---YPDLDD----PEADFELA 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 345 AVHLADAVGGSLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVFKgGKANEKDELRVSKMTTVALGVVAIVLGil 424
Cdd:cd11477 309 YPMMIKEYLPAGLLGLVLAGLLAATMSTVSTHLNWGAAYLVNDIYKRFIK-PNASEKHLLKVGRLATVLFGLLSIVVA-- 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 425 FEKQNIAFMVGLAFSIAASCNFPvLLLSMYWKKLTTRGAMIGGWMGLITAVGLMVLGPTIWVQILGHEKAIYPYEYPALF 504
Cdd:cd11477 386 LASDSIGGAFWIVLALGAGLGGP-LILPWLWWRFNAWTEIWAMIASIIVGLVVSVLLKVFGLPEDFLFSFLVPVLLSLVV 464
|
....*..
gi 15598430 505 SMIVAFV 511
Cdd:cd11477 465 WLAVTLL 471
|
|
| SLC5sbd_CHT |
cd11474 |
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ... |
37-517 |
1.72e-25 |
|
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271368 [Multi-domain] Cd Length: 464 Bit Score: 109.54 E-value: 1.72e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 37 IVMFVAFVGATLCITYWASKRNRSAADYYAAGGRITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLI-----YSIG- 110
Cdd:cd11474 1 LIGVILYYLLILGIGLWASRRVKSSEDFLLAGRSLPLPVGVFTLFATWFGGETILGAAETFYEEGLGGVAqdpfgYALCl 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 111 FLVGwpiilFLIAERLRNLGKYTFADVasyrLKQKQIRTLSACGSLVVVAFYLI---AQMVGAGKLIELLFGLNYHVAVV 187
Cdd:cd11474 81 ILGG-----LFFAKPMRRMGLLTLGDF----FRQRYGRRVEVLLSIPAVLSYLGwvaAQLVALGLVLSVILGLPVETGIL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 188 LVGILMVLYVLFGGMLATTWVQIIKAVLLLSGASFMAIMVLKHVNFDVSTLFSEAIKvhpkgEAIMSPGGLVKDPISAFS 267
Cdd:cd11474 152 ISAAIVLAYTLFGGMWSVAYTDVVQLIVIFVGLLVLVPFVLTNPGGVDIASAAAAGK-----LRFFPWLGTKSDWLIWID 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 268 LGFALMFGtaGLPHILM--RFFTVSDAKEARKSVFyaTGFIGYFyILTFIIGFGAILLVSTNPDFKDATGALIGGN---N 342
Cdd:cd11474 227 AWLTLGLG--SIPQQDVfqRVLSAKSEKTAQRLSL--LAGVGYL-LFAIPPLLIGLAAASIDPSLTQYGLEEDAQLilpL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 343 MAAVHLADAVGGsLFLGFISAVafatILAVVAGLTLAGASAVSHDLYASVFKgGKANEKDELRVSKMTTVALGVVAIVlg 422
Cdd:cd11474 302 LLQYLTPLWVQV-LFLGALLSA----VMSTADSALLAPSSVFSENIYKPPFR-PKASDRELLWVMRISVVVFGAIATL-- 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 423 ILFEKQNIAFMVGLAFSIAASCNFPVLLLSMYWKKLTTRGAMIGGWMGLITAVGLMVLGPTIwvqilghEKAIYPYEYPA 502
Cdd:cd11474 374 MALTVESIYGLVELASDLVLVGLFVPLLAGLYWKRANTYGALAAIIVGLVLRLLGGELLLGL-------PADIPPQLQGF 446
|
490
....*....|....*...
gi 15598430 503 LFS---MIVAFVGIWFFS 517
Cdd:cd11474 447 PFStlaMVIGSLLPLAVS 464
|
|
| SLC5sbd_PanF |
cd10327 |
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute ... |
37-485 |
4.45e-23 |
|
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; PanF catalyzes the Na+-coupled uptake of extracellular pantothenate for coenzyme A biosynthesis in cells. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212037 Cd Length: 472 Bit Score: 102.28 E-value: 4.45e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 37 IVMFVAFVGATLCITYWASKRNRSAA-----DYYAAGGRITGFQNGLAIAGDYMSAASFLGISALVFTSGYD-GLIYSIG 110
Cdd:cd10327 2 LLPIIIYLVILLGIGFYARRSKKRRSgdfleEYFIGGRSMGGFVLAMTLVATYTSASSFIGGPGAAYKIGLGwVLLAMIQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 111 FLVGWpIILFLIAERL----RNLGKYTFADVASYRLKQKQIRTLSACGSLVVVAFYLIAQMVGAGKLIELLFGLNYHVAV 186
Cdd:cd10327 82 VPTGF-LTLGVLGKKFaiiaRKINAVTIIDYLRARYNSKALVVLSSLALIVFFIAAMVAQFIGGARLLEAVTGLSYVTGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 187 VLVGILMVLYVLFGGMLATTWVQIIKAVLLLSGASFMAIMVLKHVNfDVSTLFSEAIKVHPKgeAIMSPGGLVKDPISAF 266
Cdd:cd10327 161 LIFGLTVILYTTIGGFRAVALTDAIQGIVMIIGTVLLLVGVLAAGG-GMEAIMATLAEIDPN--LLTPFGPGFLSPPYIL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 267 SLGFALMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAILLVsTNPDFKDATGALIGGNNMAAv 346
Cdd:cd10327 238 SFWVLVGFGVIGLPQTAVRCMGYKDSKSMHRAMIIGTVVVGFLMLGMHLAGVLGRAVL-PDLEVPDKVIPTLALKVLPP- 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 347 HLAdavggslflGFISAVAFATILAVVAGLTLAGASAVSHDLYA-SVFKGGKANEKDELRVSKMTTVALGVVAIVLGIlf 425
Cdd:cd10327 316 WLA---------GLFLAGPLAAIMSTVDSQLILASSAIVKDLYLnYKNKEKKTSEKKVKRISLIITIILGLLVFLLAI-- 384
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15598430 426 ekQNIAFMVGL---AFSIAASCNFPVLLLSMYWKKLTTRGAMIGGWMGLITAVGLMVLGPTIW 485
Cdd:cd10327 385 --NPPDLIVWLnlfAFGGLEAAFFWPLVLGLYWKRANATGALASMVVGLVSYILITYLKIKIL 445
|
|
| PRK15419 |
PRK15419 |
sodium/proline symporter PutP; |
32-525 |
1.56e-22 |
|
sodium/proline symporter PutP;
Pssm-ID: 185317 Cd Length: 502 Bit Score: 100.86 E-value: 1.56e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 32 LNVSAIVMFVAFVGATLCITYWASKRNRSAADYYAAGGRITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSIGF 111
Cdd:PRK15419 3 ISTPMLVTFCVYIFGMILIGFIAWRSTKNFDDYILGGRSLGPFVTALSAGASDMSGWLLMGLPGAVFLSGISESWIAIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 112 LVGWPIILFLIAERLR-----NLGKYTFADVASYRLKQKQ--IRTLSACGSLVVVAFYLIAQMVGAGKLIELLFGLNYHV 184
Cdd:PRK15419 83 TLGAWINWKLVAGRLRvhteyNNNALTLPDYFTGRFEDKSriLRIISALVILLFFTIYCASGIVAGARLFESTFGMSYET 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 185 AVVLVGILMVLYVLFGGMLATTWVQIIKAVLLLSGASFMAIMVLKHVNFDVSTLfsEAIKVHPKGEAIMSPGGLVKDPIS 264
Cdd:PRK15419 163 ALWAGAAATILYTFIGGFLAVSWTDTVQASLMIFALILTPVIVIISVGGFGDSL--EVIKQKSIENVDMLKGLNFVAIIS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 265 AFSLGfalmFGTAGLPHILMRFFtvsdAKEARKSVFYATGFIGYFYILTF----IIGFGAILLVSTNPDFkdaTGALIGG 340
Cdd:PRK15419 241 LMGWG----LGYFGQPHILARFM----AADSHHSIVHARRISMTWMILCLagavAVGFFGIAYFNEHPAV---AGAVNQN 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 341 NNMAAVHLADAVGGSLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVFKGGkANEKDELRVSKMTTVALGVVAIV 420
Cdd:PRK15419 310 AERVFIELAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKH-ASQKELVWVGRVMVLVVALVAIA 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 421 LGILFEKQNIAfMVGLAFSIAASCNFPVLLLSMYWKKLTTRGAMIGGWMGLITAVglmvlgptIWVQilghekaiypYEY 500
Cdd:PRK15419 389 LAANPENRVLG-LVSYAWAGFGAAFGPVVLFSVMWSRMTRNGALAGMIIGALTVI--------VWKQ----------FGW 449
|
490 500
....*....|....*....|....*....
gi 15598430 501 PALFSMIVAFV----GIWFFSITDKSAAA 525
Cdd:PRK15419 450 LGLYEIIPGFIfgsiGIVVFSLLGKAPSA 478
|
|
| SLC5sbd_u3 |
cd11479 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
37-480 |
5.21e-21 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271373 Cd Length: 454 Bit Score: 95.75 E-value: 5.21e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 37 IVMFVAFVGATLCITYWASKRNRSAADYYAAGGRItgfqnGLAIAGDYMSA-----ASFLGISALVFTSGYDG--LIYSI 109
Cdd:cd11479 3 YGVIALYFAAMIAIGWWGMRRAKTSEDYLVAGRRL-----GPGLYLGTMAAvvlggASTIGGVGLGYQYGISGmwLVVAI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 110 GflVGWPIILFLIAERLRNLGKYTFADVasyrLKQKQIRTLSACGSLVVVAFYL---IAQMVGAGKLIELLFGLNYHVAV 186
Cdd:cd11479 78 G--LGILALSLLLAKRIARLKVYTVSEV----LELRYGPSARVISALVMLAYTLmvaVTSTIAIGTVFSVLFGLPRTLSI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 187 VLVGILMVLYVLFGGMLATTWVQIIKAVLLLSGASFMAIMVLKHVNFDVSTLFSEAikvhpkGEAIMSPGGLVKDPISAF 266
Cdd:cd11479 152 LVGGGIVVLYSVLGGMWSITLTDIIQFVIKTIGIFLLLLPLALSKAGGLSGLQEKL------PASYFDLTSIGWDTIVTY 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 267 SL--GFALMFGTaglpHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAILLVstnPDFKDATGALIggnNMA 344
Cdd:cd11479 226 FLlyFFGILIGQ----DIWQRVFTARSEKVARWGGVAAGLYCVLYGVAGALIGMAAAVLL---PDLANPQNAFA---TMA 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 345 AVHLADAVggslfLGFISAVAFATILAVVAGLTLAGASAVSHDLYASvFKGGKANEKDELRVSKMTTVALGVVAIVLGIL 424
Cdd:cd11479 296 QEVLPVGL-----RGLVLAAALAAMMSTASGALLASSTVLTNDVLPR-LRRKNESERSEVRLSRLFTLLLGVVVIVIAVL 369
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 15598430 425 FekQNIAFMVGLAFSIAASCNFPVLLLSMYWKKLTTRGAMIGGWMGLITAVGLMVL 480
Cdd:cd11479 370 V--NDVVAALTIAYAILVGGLLVPILGGLFWKRATGAGALASMVAGSVVVLAGMAV 423
|
|
| SLC5sbd_NIS-like_u3 |
cd11495 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
38-485 |
6.70e-19 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271386 [Multi-domain] Cd Length: 473 Bit Score: 89.52 E-value: 6.70e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 38 VMFVAFVGATLCITYWASKRNRSAADYYAAGGRITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSIGFLVGWPI 117
Cdd:cd11495 7 LVLVIYLLAMLGIGLYFSKKQKSTDDYFKGGGRIPWWAAGLSIFATTLSSITFLAIPGKAYATDWNYFVGSLSIIIAAPL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 118 ILFLIAERLRNLGKYTfadvASYRLKQKQIRTLSACGSLvvvaFYLIAQMVGAGKLIEL-------LFGLNYHVAVVLVG 190
Cdd:cd11495 87 AAYFFVPFFRRLNVTS----AYEYLEKRFGPWARVYGSL----LFILFQLGRMGIVLYLpalalsaVTGINPYIIIILMG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 191 ILMVLYVLFGGMLATTWVQIIKAVLLLSGASFMAIMVLKHVNFDVSTLFSEAIKVH-----PKGEAIMSPGGLVkdpISA 265
Cdd:cd11495 159 VLCIIYTVLGGIEAVIWTDVIQGVVLLGGALLCLIILLFSIPGGFGEVFDIAIANGkfslgDFSFSLTESTIWV---IFI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 266 FSLGFALMFGTAGlPHILMRFFTVSDAKEARKSVFyaTGFIGYFYILTFIIGFGAILLV--STNPDFKDATGAliggnnm 343
Cdd:cd11495 236 GGIFNNLQSYTSD-QDVVQRYLTTKSIKEAKKSLW--TNALLALPVALLFFGIGTALYVfyQQHPELLPAGIN------- 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 344 aavhladavGGSLFLGFIsavafATILAV-VAGLTLAG----------------ASAVSHDLYASVFKGgkANEKDELRV 406
Cdd:cd11495 306 ---------GDAVFPYFI-----VTQLPVgVAGLIIAAifaaamstissslnsvATCITTDFYKRLSPD--PSDKQYLKV 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 407 SKMTTVALGVVAIVLGILFEKQNIAFMVGLAFSIAASCNFPVL---LLSMYWKKLTTRGAMIGGWMGLITAVGLMVLGPT 483
Cdd:cd11495 370 ARLITLLVGLLGTLVALYLANAGVKSLLDAFNTLTGLFGGGLAglfLLGIFTKRANAKGALVGIIVSIIVIFWISLLYTP 449
|
..
gi 15598430 484 IW 485
Cdd:cd11495 450 IH 451
|
|
| SLC5sbd_DUR3 |
cd11476 |
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is ... |
36-475 |
3.06e-16 |
|
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is the yeast plasma membrane urea transporter. Saccharomyces cerevisiae DUR3 also transports polyamine. The polyamine uptake of S. cerevisiae DUR3 is activated upon its phosphorylation by polyamine transport protein kinase 2 (PTK2). S. cerevisiae DUR3 also appears to play a role in regulating the cellular boron concentration. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271370 Cd Length: 493 Bit Score: 81.48 E-value: 3.06e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 36 AIVMFVAFVGATLCITY--WASKRNRSAADYYAAGGRITGFqnGLAIAG---DYMSAASFLGISALVFTSGYDGLI-YSI 109
Cdd:cd11476 4 VIGLGALFALLMVFITRllKRYRGKNQSSEEFMTAGRSVGT--GLTAAAivsSWTWAATLLQSATVAYQYGVSGPFwYAS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 110 GFLVgwPIILF-LIAERLRNL--GKYTFADVASYRLKQKQIRTLSACgSLVVVAFYLIAQMVGAGKLIELLFGLNYHVAV 186
Cdd:cd11476 82 GATL--QILLFaPLAIRIKRLapNAHTLLEIVRARYGTAAHLVFLVF-ALFTNVIVLAMLLLGGSAVVNALTGMPIVAAS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 187 VLVGILMVLYVLFGGMLATTWVQIIKAVLLLSGASFMAIMVL-KHVNFDVSTLFSEAIKVHPKgEAIMSPGGLVKDPISA 265
Cdd:cd11476 159 FLIPLGVLLYTLFGGLRATFLTDYIHTVIILIILLVFAFAVYtSSDIGSPSKVYDLLQEAAPD-LPVEGNQGSYLTFKSK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 266 FSLGFALMFGTAGLPHILM------RFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAILLvSTNPDFKDatgaliG 339
Cdd:cd11476 238 AGLIFGIINIVGNFGTVFLdqgywqRAIAARPSAAVKGYFLGGLAWFAIPFLLATTLGLAALAL-GLNPTFEE------V 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 340 GNNMAAVHLADAVGGSLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVFKgGKANEKDELRVSKMTTVALGVVAI 419
Cdd:cd11476 311 SAGLVLPYVAAALLGKGGAAAVLVLLFMAVTSTASAELIAVSSIVTYDIYRTYIN-PNATGKQLLRVSRIAVIGFGLFMG 389
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 15598430 420 VLGILFEKQ--NIAFMVGLAFSIAASCNFPVlLLSMYWKKLTTRGAMIGGWMGLITAV 475
Cdd:cd11476 390 GLAVGLNYIgiSLGWLLLFMGILIGSAVFPV-ALGLYWRRQTGTAAVVSPIAGLVAGL 446
|
|
| SLC5sbd_NIS-like_u2 |
cd11494 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
37-472 |
2.69e-15 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters, SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271385 [Multi-domain] Cd Length: 473 Bit Score: 78.41 E-value: 2.69e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 37 IVMFVAFVGaTLCITYWASKRNRSAADYYAAGGRITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSIGFLVGWP 116
Cdd:cd11494 4 IVLVGYLLG-ILVYGVYKGRGQKNQEDYFLGGRSMPWWPIGLSIMATQASAITFLSAPGQAYSDGMRFVQYYFGLPLAMI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 117 IILFLIAERLRNLGKYTFADVASYRLKQKQiRTLSACGSLVVVAFYlIAQMVGAGKLI-ELLFGLNYHVAVVLVGILMVL 195
Cdd:cd11494 83 FLCITFVPVFYKLKVYTAYEYLERRFGLKT-RLLTSILFLISRGLA-TGVTIYAPAIIlSTILGWSLWLTILLIGGITII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 196 YVLFGGMLATTWVQIIKAVLLLSGASFMAIMVLKHVNFDVSTLFSEAIKvHPKGEAI-MSPGGLVKDPISAFSLGFALM- 273
Cdd:cd11494 161 YTVLGGIKAVIWTDVIQMVIIWAGLFIAFGLLLKLLPVGFVDALLVAGK-SGRLNALdFSFDLSDTYTFWSGLIGGFFLy 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 274 ---FGTAGLphILMRFFTVSDAKEARKSVFyATGFIGyFYILTFIIGFGAILLV--STNPDFKDATGALIGGNNMAAVHL 348
Cdd:cd11494 240 lsyFGTDQS--QVQRYLTAKSIKEARKSLL-LNGFLK-FPMQFFILLIGVLVFVfyQFNPFPVSFNPAEDETKDTNYIFL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 349 aDAVGGSL---FLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVFKGGkANEKDELRVSKMTTVALGVVAIVLGILF 425
Cdd:cd11494 316 -RFVLNYLppgVIGLLIAAIFAAAMSSIDSALNSLATVTVIDIYRRFFKKD-ASDEHYLKVSRLLTVFWGLLAIVFALFA 393
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 15598430 426 EK-QNIAFMVGLAFSIAASCNFPVLLLSMYWKKLTTRGAMIGGWMGLI 472
Cdd:cd11494 394 GLaGSLIEAVNKLGSLFYGPILGVFLLAFFTKKANGKGVFAGAILGVI 441
|
|
| SLC5sbd_u2 |
cd11478 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
41-511 |
1.03e-14 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271372 Cd Length: 496 Bit Score: 76.56 E-value: 1.03e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 41 VAFVGATLCITYWASKRNRSAADYYAAGGRITGFQNGLAIAGDYMSAASFLGISA-------LVFTSGYDGLIYSIGFLv 113
Cdd:cd11478 7 AVYFVFVLGIGFYLKRKVKTSEDFFLSGRSLPAWITGLAFISANLGALEIVGMSAngaqygiATVHFYWIGAIPAMVFL- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 114 GWPIILFLIAERLRNLGKYtfadvasyrLKQ---KQIRTLSACGSLVVVAFYLIAQMVGAGKLIELLFGLNYHVAVVLVG 190
Cdd:cd11478 86 GIVMMPFYYGSKVRSVPEY---------LKLrfnKSTRLLNAVSFAVMTILMSGINLYALALVLNVLLGWPLWLSIILSA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 191 ILMVLYVLFGGMLATTWVQIIKAVLLLSGASFMAIMVLKHV--------NFDVSTLFSeAIKVHPKGEAIMSPGGLVKDP 262
Cdd:cd11478 157 AIVLAYTTLGGLTSAIYNEVLQFFLIVAGLIPLVIIGLIKVggwdglseKIDANGPPG-WNGLSWGPQGSQSTNPMGVNL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 263 ISAFSLGFALMFGTAGLPH-ILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAILLVSTNPDFKDATGaliggn 341
Cdd:cd11478 236 GLVFGLGFVLSFGYWTTNFlEVQRAMAAKDLSAARRTPLIAAFPKMFIPFLVILPGLIALVLVPELGASGGLDY------ 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 342 NMAAVHLADAVGGSLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVFKGGKaNEKDELRVSKMTTVALGVVAIVL 421
Cdd:cd11478 310 NQALPYLMAKYLPPGLLGLGITALLAAFMSGMAGNVSAFNTVFTYDIYQTYIVKDA-PDKHYLKVGRIATVVGVLISIGT 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 422 G-ILFEKQNIAFMVGLAFSIAASCNFPVLLLSMYWKKLTTRGAMIGGWMGLITAVGLMVLGPTIWVQILGHEKAIYpyeY 500
Cdd:cd11478 389 AyIASSFNNIMDYLQLLFSFFNAPLFATFLLGMFWKRATPWGGFWGLLAGTASAIVLYGLYELGLIVYHSDMAPNF---Y 465
|
490
....*....|.
gi 15598430 501 PALFSMIVAFV 511
Cdd:cd11478 466 GAWWAFVVCFV 476
|
|
| SLC5sbd_NIS-like |
cd10326 |
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ... |
37-441 |
1.34e-12 |
|
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and 2. SMCT1(the product of the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (product of the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271361 [Multi-domain] Cd Length: 472 Bit Score: 69.90 E-value: 1.34e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 37 IVMFVAFVGATLCITYWASKRNRSAADYYAAGGRITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSIGFLVGWP 116
Cdd:cd10326 2 WAVVVVYFLILLAISYYTSRRNADNDDFFLGNRQSPWYLVAFSMIGTSLSGVTFVSVPGEVGGSGFTYLQMVLGFLLGYL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 117 IILFLIAERLRNLGKYTfadVASYrLKQKQIRTLSACGSLvvvaFYLIAQMVGAGKLIEL-----------LFGLNYHVA 185
Cdd:cd10326 82 IIAFVLLPLYYRLNLTS---IYEY-LEDRFGVSSRKTGAV----FFLLSRILGAGIRLYLvalvlqqflfdSLGIPFWLT 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 186 VVLVGILMVLYVLFGGMLATTWVQIIKAVLLLSGASFMAIMVLKHVNFDVSTLFSEAikvhpkGEAIMSPGGLVKDPISA 265
Cdd:cd10326 154 VLITGLLIWLYTFRGGIKTVVWTDTLQTVFLLVGLVLTIIIISNSLGLGFGEAISAA------GESGYSRIFNFDDDNSR 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 266 FSL------GFALMFGTAGLPHILM-RFFTVSDAKEARKSVFYaTGFIGYFYILTFiIGFGAILLVstnpdFKDATGALI 338
Cdd:cd10326 228 RTFwkqflgGIFITIAMTGLDQDMMqRNLSCKNLKDAQKNMLT-FGVILVPVNLLF-LLLGVLLYT-----YAQKNGIAL 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 339 GGNN-------MAAVHLADAVGGSLFLGFISAvAFATILAVVAGLTlagaSAVSHDLYasvfkggKANEKDELRVSKMTT 411
Cdd:cd10326 301 PAKDsdqlfpyFALNGLPPGVSGLFVAGIIAA-AMSSADSALTALT----TSFCVDIL-------NRFKRKSEKKSERKY 368
|
410 420 430
....*....|....*....|....*....|...
gi 15598430 412 VALGV-VAIVLGILFEKQ--NIAFMVGLAFSIA 441
Cdd:cd10326 369 VHIAFsLTFVLGILVFGSasNSGSLIDAIFKVA 401
|
|
| SLC5sbd_NIS-like_u1 |
cd11493 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
37-480 |
2.36e-12 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271384 [Multi-domain] Cd Length: 479 Bit Score: 69.16 E-value: 2.36e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 37 IVMFVAFVGATLCITYWASKRNRSAADYYAAGGRITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSIGFLVGWP 116
Cdd:cd11493 2 LAVIVLYLLGLPLLGLWLSGRQKSTADYFLGGRSMPWWAVCLSVVATETSTLTFLSIPGLAYGGDLTFLQLALGYILGRI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 117 IILFLIAERLRNLGKYTFADVASYRLKQKQIRTLSA---CGSLVV--VAFYLIAQMVGAGkLIELLFGLNYHVAVVLVGI 191
Cdd:cd11493 82 IVAFVLLPRYFRGEVVSAYELLGQRFGGGMQKTASVtflVTRLLAdgVRLFAAAIPVSMI-LGADGVALSYIASILIISV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 192 LMVLYVLFGGMLATTWVQIIKAVLLLSGASFMAIMVLKHVNFDVSTLFSEAIKVHpKGEAIMSPGGLVKD--PISAFSLG 269
Cdd:cd11493 161 VTLLYTYFGGIRAVVWTDVIQLVVYIGGAVAALAYLLGALPADWLQIAAAAGKFH-LFDLSDLILGLTSPytFWAAIIGG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 270 FALMFGTAGLPHILM-RFFTVSDAKEARKSVFyATGFIGYFYILTFIIgFGAILLVstnpdfkdatgaLIGGNNMAAVHL 348
Cdd:cd11493 240 ALLSMASHGTDQLMVqRLLACRNLRDAQKALI-GSGVVVFPQFALFLL-IGLLLYV------------YYGGASLAALGL 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 349 ADAVggSLFLGFIsavaFATILAVVAGLTLAG--ASAVS--------------HDLYASvFKGGKANEKDELRVSKMTTV 412
Cdd:cd11493 306 GSPD--EVFPYFI----VHELPAGLRGLLIAGilAAAMStlssalnslasstvQDLYQP-WKRRRLSDEKLLRASRLLTL 378
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15598430 413 ALGVVAIVLGILFEKQNIAfMVGLAFSIAA---SCNFPVLLLSMYWKKLTTRGAMIGGWMGLITAVGLMVL 480
Cdd:cd11493 379 VWAVVLVGIALLFQYTDQP-VVELGLSIASftyGGLLGVFLLGLLTRRASQRDAIAAFIVGFLVMLLLIFG 448
|
|
| SLC5sbd_SGLT1-like |
cd10329 |
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily ... |
37-480 |
5.19e-12 |
|
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily includes the solute-binding domain of SGLT proteins that cotransport Na+ with various solutes. Its members include: the human glucose (SGLT1, -2, -4, -5 ), chiro-inositol (SGLT5), and myo-inositol (SMIT) cotransporters. It also includes human SGLT3 which has been characterized as a glucose sensor and not a transporter. It belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271363 Cd Length: 538 Bit Score: 68.37 E-value: 5.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 37 IVMFVAFVGATLCITYWASKRNRS-AADYYAAGGRITGFQNGLAIAGDYMSAASFLGISALVFTSGYdgLIYSIGFLVGW 115
Cdd:cd10329 1 IVIIAVYFVAVIAIGLWSSRKKRStVSGYFLAGRSMGWPVIGASLFASNIGSSHLVGLAGSGAASGI--AVGNYEWNAAF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 116 PIILF--LIAERLRNLGKYTFADVASYRLKQKqIRTLSACGSLVVVAFYLIAQMVGAGKL-IELLFGLNYHVAVVLVGIL 192
Cdd:cd10329 79 VLLLLgwVFLPFYIRSGVSTMPEFLEKRFGGR-SRVYLSVLSLILYVFTKISVDLYAGALvIKQLLGWDLYLSIIVLLVI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 193 MVLYVLFGGMLATTWVQIIKAVLLLSGASFMAIMVLKHVNFDVSTLFsEAIKVHPKGEaimspggLVKDPISAFSLGFAL 272
Cdd:cd10329 158 TAIYTIAGGLKAVIYTDTLQAVILIIGSAILMFLAFNEVGGGWSAYM-AAIPSGTAFH-------LFRPPDDPDLPWPGL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 273 MFGTAGL--------PHILMRFFTVSDAKEARKSVFyatgFIGYFYILTFII----GFGAILLVSTNPDFKDATGALIGG 340
Cdd:cd10329 230 LLGYPILgiwywctdQVIVQRVLAAKNLKHARRGAL----FAGYLKLLPLFLmvlpGMIARALFPDLVACVVPCGNGVGC 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 341 NNMAAVHLADAVGGSLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVFKggKANEKDELRVSKMTTVALGVVAIV 420
Cdd:cd10329 306 SDIAYPTLVTELLPVGLRGLVLAVLLAALMSSLTSIFNSASTLFTMDIYKRLRP--EASEKELVRVGRIATLVVVVISIL 383
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15598430 421 L--------GILFEK-QNIAFMvgLAFSIAAscnfpVLLLSMYWKKLTTRGAMIGGWMGLITAVGLMVL 480
Cdd:cd10329 384 WapiiqaqgGSLFNYiQSVLSY--LAPPIAA-----VFLLGIFWKRTNEQGAFWGLIAGLVLGLVRLIL 445
|
|
| PRK10484 |
PRK10484 |
putative transporter; Provisional |
36-466 |
1.34e-07 |
|
putative transporter; Provisional
Pssm-ID: 236699 [Multi-domain] Cd Length: 523 Bit Score: 54.12 E-value: 1.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 36 AIVMFVAFVGATLCITYWASKR--NRSAADYYAAGGRITGFqnglAIAGDYM----SAASFLGISALVFTSGYDGLIYSI 109
Cdd:PRK10484 3 TILSFLGFTLLVAVISWWKTRKtdTSSSDGYFLAGRSLTGP----VIAGSLLltnlSTEQLVGLNGQAYASGMSVMAWEV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 110 GFLVGWPIILFLIAERLRNLGKYTFADVASYRLkQKQIRTLSACGSLVVVAFYLIAQMVGAGKL-------IELLFGLNY 182
Cdd:PRK10484 79 TAAIALIILALIFLPRYLKSGITTIPDFLEERY-DKTTRRIVSILFLIGYVVSFLPIVLYSGALalnslfhVSELLGISY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 183 HVA----VVLVGILMVLYVLFGGMLATTWVQIIKAVLLLSGASFMAIMVLKHV-NFDVSTLFSEAIKVHP-KGEAIMSPG 256
Cdd:PRK10484 158 GAAiwllVWLIGIIGAIYAVFGGLKAVAVSDTINGIGLLIGGLLVPVFGLIALgDGSFMQGLEQLTTVHPeKLNSIGGAT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 257 GLVKDPISAFSLGFALMFGTAGLPHILMRFFTVSDAKEARKSVFYATGF--IGYFY-ILTFIIGFGAILLVSTNPDfkda 333
Cdd:PRK10484 238 DPVPFPTLFTGLILVNLFYWCTNQSIVQRALGAKNLAEGQKGALLAAFFklLGPLIlVLPGIIAFHLYGDGLPNAD---- 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 334 tgaliggnnMAAVHLADAVGGSLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVFKgGKANEKDELRVSKMTTVA 413
Cdd:PRK10484 314 ---------MAYPTLVNDVLPVPLVGFFAAVLFGAILSTFNGFLNSASTLFSLDIYKPIIN-PNASEKQLVKVGKKFGFV 383
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 414 LGVVAIVLGILfekqnIAFMVGLAFSIAASCN-------FPVLLLSMYWKKLTTRGAMIG 466
Cdd:PRK10484 384 LAIISMIVAPL-----IANAPQGLYSYLQQLNgiynvpiLAIIIVGFFTKRVPALAAKVA 438
|
|
| SLC5sbd_SGLT5 |
cd11489 |
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is ... |
33-480 |
7.78e-06 |
|
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is a glucose transporter, which also transports galactose. It is encoded by the SLC5A10 gene, and is exclusively expressed in the renal cortex. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212058 Cd Length: 604 Bit Score: 48.78 E-value: 7.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 33 NVSAIVMFVAFVGATLCITYWASKR--NRSAADYYAAGGRITGFQNGLAIAGDYMSAASFLGISAlvftSGYDGLIYSIG 110
Cdd:cd11489 1 SVADIIVIGVYFALNVAVGIWSSCRvsRNTVSGYFLAGRDMAWWPIGASLFASSEGSGLFIGLAG----TGAAGGIAVAG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 111 F---------LVGWPIILFLIAERLRNLGKYTfadvaSYRLKQKQIRTLSACGSLVVVAFYLIAQMVGAGKL-IELLFGL 180
Cdd:cd11489 77 FewnatyallALAWVFVPVYISSGIVTMPEYL-----QRRFGGERIRMYLSVLSLLLSVFTKISTDLYSGALfVQVCLGW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 181 NYHVAVVLVGILMVLYVLFGGMLATTWVQIIKAVLLLSGASFMAIMVLKHVN--FDVSTLFSEAIKVH---------PKG 249
Cdd:cd11489 152 NLYLSTVLMLVVTALYTIAGGLAAVIYTDALQTLIMVIGAVILTIKAFNQIGgySNLEEAYLQAVPSKiipnttchlPRA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 250 EAIMspggLVKDPISAFSLGFALMFGTAGLPH--------ILMRFFTVSDAKEARKSVFYATgfigYFYILT--FIIGFG 319
Cdd:cd11489 232 DAMH----LFRDPVTGDLPWTGMTFGLTIMATwywctdqvIVQRSLSARSLSHAKGGSILAS----YLKMLPmgLIIMPG 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 320 AILLVSTNPDFK--------DATGALIGGNNMAAVHLADAVGGSLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYAS 391
Cdd:cd11489 304 MISRALFPDDVAcvdpeeclRVCGAEVGCSNIAYPKLVMELMPSGLRGLMIAVMMAALMSSLTSIFNSSSTLFTMDIWRR 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 392 VFKGgkANEKDELRVSKMTTVALGVVAIVLGILFEKQNIAFMVGLAFSIAASCNFPV---LLLSMYWKKLTTRGAMIGGW 468
Cdd:cd11489 384 LRPG--ASERELLLVGRLVTVILVGVSVVWIPILQSSNSGQLYIYIQSVTSYLAPPVtavFVLAVFWRRANEQGAFWGLM 461
|
490
....*....|..
gi 15598430 469 MGLITAVGLMVL 480
Cdd:cd11489 462 AGLVVGLTRMVL 473
|
|
| SLC5sbd_SGLT1 |
cd11486 |
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a ... |
33-479 |
1.46e-05 |
|
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a high-affinity/low-capacity glucose transporter, which can also transport galactose. In the transport mechanism, two Na+ ions first bind to the extracellular side of the transporter and induce a conformational change in the glucose binding site. This results in an increased affinity for glucose. A second conformational change in the transporter follows, bringing the Na+ and glucose binding sites to the inner surface of the membrane. Glucose is then released, followed by the Na+ ions. In the process, hSGLT1 is also able to transport water and urea and may be a major pathway for transport of these across the intestinal brush-border membrane. hSGLT1 is encoded by the SLC5A1 gene and expressed mostly in the intestine, but also in the trachea, kidney, heart, brain, testis, and prostate. The WHO/UNICEF oral rehydration solution (ORS) for the treatment of secretory diarrhea contains salt and glucose. The glucose, along with sodium ions, is transported by hSGLT1 and water is either co-transported along with these or follows by osmosis. Mutations in SGLT1 are associated with intestinal glucose galactose malabsorption (GGM). Up-regulation of intestinal SGLT1 may protect against enteric infections. SGLT1 is expressed in colorectal, head and neck, and prostate tumors. Epidermal growth factor receptor (EGFR) functions in cell survival by stabilizing SGLT1, and thereby maintaining intracellular glucose levels. SGLT1 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5)transporter family.
Pssm-ID: 271379 Cd Length: 636 Bit Score: 48.01 E-value: 1.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 33 NVSAIVMFVAFVgatLCITYWASKR-NR-SAADYYAAGGRITGFQNGLAIAGDYMSAASFLGISALVFTSG-------YD 103
Cdd:cd11486 2 DISVIVIYFVVV---LAVGVWAMVStNRgTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGIAGTGAAAGiaiggfeWN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 104 GLIYSIgfLVGWPIILFLIAErlrnlGKYTFADVASYRLKQKQIRTLSACGSLVVVAFYLI-AQMVGAGKLIELLFGLNY 182
Cdd:cd11486 79 ALVVVV--VLGWLFVPIYIKA-----GVVTMPEYLRKRFGGQRIQVYLSVLSLCLYIFTKIsADIFSGAIFINLALGLNL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 183 HVAVVLVGILMVLYVLFGGMLATTWVQIIKAVLLLSGASFMAIMVLKHV----NF------DVSTLFSEAIKVH------ 246
Cdd:cd11486 152 YLAIVILLAITALYTITGGLAAVIYTDTLQTIIMVVGSFILMGFAFNEVggydAFmekymtAIPSVIGTGNSTSqekcyt 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 247 PKGEAIMspggLVKDPISAFSLGFALMFGTAglphILMRFFTVSD------AKEARKSVFYATGFI--GYFYIL-TFIIG 317
Cdd:cd11486 232 PRADSFH----IFRDPITGDLPWPGLLFGLS----ILTLWYWCTDqvivqrCLSAKNMSHVKAGCIlcGYLKLLpMFIMV 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 318 FGAIL--------LVSTNPDF-KDATGALIGGNNMAAVHLADAVGGSLFLGFISAVAFATILAVVAGLTLAGASAVSHDL 388
Cdd:cd11486 304 MPGMIsrilytdeIACVVPDEcKAVCGTEVGCTNIAYPKLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDI 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 389 YASVFKggKANEKDELRVSKMTTVALGVVAIVLGILFEKQNIAFMVGLAFSIAASCNFP---VLLLSMYWKKLTTRGAMI 465
Cdd:cd11486 384 YTKVRK--KASEKELMIAGRLFMLVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPiaaVFLLAIFCKRVNEPGAFW 461
|
490
....*....|....
gi 15598430 466 GGWMGLITAVGLMV 479
Cdd:cd11486 462 GLCVGLLVGLARMI 475
|
|
| SLC5sbd_NIS |
cd11503 |
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of ... |
39-227 |
3.11e-05 |
|
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. NIS is expressed in the thyroid, colon, ovary, and in human breast cancers. It mediates the active transport and the concentration of iodide from the blood into thyroid follicular cells, a fundamental step in thyroid hormone biosynthesis, and is the basis of radioiodine therapy for thyroid cancer. Mutation in the SLC5A5 gene can result in a form of thyroid hormone dysgenesis. Human NIS exists mainly as a dimer stabilized by a disulfide bridge. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271393 Cd Length: 535 Bit Score: 46.76 E-value: 3.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 39 MFVAFVGATLCITYWASKRN---RSAADYYAAGGRITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSIGFLVGW 115
Cdd:cd11503 5 VFAAMLLVSTGIGLFVGLARggqRSADDFFTGGRGLSAVPVGLSLSASFMSAVQVLGVPSEAYRYGLKFLWMCLGQLLNS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 116 PIILFLIAERLRNLGKYTFADVASYRLKqkqiRTLSACGSLVvvafYLIAQMVGAGKLI-------ELLFGLNYHVAVVL 188
Cdd:cd11503 85 LMTAVLFMPVFYRLGITSTYQYLEMRFS----RAVRLCGTLQ----FIVATMLYTGIVIyapalilNQVTGLDIWASLFS 156
|
170 180 190
....*....|....*....|....*....|....*....
gi 15598430 189 VGILMVLYVLFGGMLATTWVQIIKAVLLLSGasFMAIMV 227
Cdd:cd11503 157 TGIICTFYTTVGGMKAVIWTDVFQVVVMLSG--FWAVLI 193
|
|
| SLC5sbd_YidK |
cd10328 |
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; ... |
40-510 |
1.12e-04 |
|
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Uncharacterized subfamily of the solute binding domain of the solute carrier 5 (SLC5) transporter family (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily includes the uncharacterized Escherichia coli YidK protein, and belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271362 Cd Length: 472 Bit Score: 44.83 E-value: 1.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 40 FVAFVGATLCITYWASK--RNRSAADYYAAGGRITGFqnglAIAGDYM----SAASFLGISALVFTSGYDGLIYSIGFLV 113
Cdd:cd10328 1 FLLFTALVALISWYKTRgdDLSSSDGYFLAGRSLTGV----VIAGSLLltnlSTEQLVGLNGQAYALGMSVMAWEVTAAI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 114 GWPIILFLIAERLRNLGKYTFADVASYRLkQKQIRTLSACGSLVVVAFYLIAQMVGAGKL-------IELLFGLNYHVA- 185
Cdd:cd10328 77 ALIILALVFLPRYLKGGITTIPEFLEERY-DETTRRIVSILFLLGYVVILLPIVLYSGALalnslfdVSELLGISYFQAl 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 186 ---VVLVGILMVLYVLFGGMLATTWVQIIKAVLLLSGASFMAIMVLKHV-NFDVSTLFSEAIKVHP-KGEAIMSPGGLVk 260
Cdd:cd10328 156 wllVWLIGIIGAIYAIFGGLKAVAVSDTINGVGLLIGGLLIPILGLIALgDGSFLAGLDTLLTAHPeKLNAIGGADSPV- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 261 dPISAFSLG--FALMFGTAGLPHILMRFFTVSDAKEARKSVFYAtgfiGYFYILTFII----GFGAILLVstnpdfkdat 334
Cdd:cd10328 235 -PFSTLFTGmlLVNLFYWCTNQAIIQRALAAKNLKEGQKGVLLA----GFFKLLVPLIlvlpGIIAFHLY---------- 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 335 GALIGGNNMAAVHLADAVGGSLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVFKgGKANEKDELRVSKMTTVAL 414
Cdd:cd10328 300 GDGLENADMAYPTLVADVLPKWLSGFFAAVLFGAILSSFNSALNSAATLFSLDIYKPIIN-KNATDKQLVKVGKIFGIVL 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 415 GVVAIVLGILFEKQN---IAFMVGLA--FSIAAscnFPVLLLSMYWKKLTTRGAMIggwmGLITAVGLMVLGptiwvQIL 489
Cdd:cd10328 379 ALISMIIAPFIAYAPeglFNYLQQFNgfFSIPI---LAIVLVGFFTKRVPALAAKI----ALIFGVILYALL-----QFV 446
|
490 500
....*....|....*....|.
gi 15598430 490 GHEKAIYPYEYPALFSMIVAF 510
Cdd:cd10328 447 FLVPIHFLHVLAILFVICVAI 467
|
|
| SLC5sbd_vSGLT |
cd10325 |
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute ... |
38-484 |
1.19e-04 |
|
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; vSGLT transports D-galactose, D-glucose, and alpha-D-fucose, with a sugar specificity in the order of D-galactose >D-fucose >D-glucose. It transports one Na+ ion for each sugar molecule, and appears to function as a monomer. vSGLT has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271360 Cd Length: 523 Bit Score: 44.60 E-value: 1.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 38 VMFVAFVGATLCITYWASK----RNRSAADYYAAGGRITGFQNGLAIAGDYMSAASFLGISALVFTSG-----YDgLIYS 108
Cdd:cd10325 1 VIFIVYVILIIGLGLWVSRekkgGEKDATDYFLAGKSLPWWAIGASLIAANISAEQFIGMSGSGFAIGlaiasYE-WMAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 109 IGFLVgwpIILFLIAERLRNlGKYTFADVASYRLkQKQIRTLSACGSLVVVAFYLIAQMVGAGKL-IELLFGLNYHVAVV 187
Cdd:cd10325 80 ITLII---VAKFFLPIFLKN-GIYTMPQFLEERY-DGRVRTIMAVFWLLLYVFVNLTSVLYLGALaIETITGIPLTYSII 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 188 LVGILMVLYVLFGGMLATTWVQIIKAVLLLSGASFMAIMVLKHV-----NFDVSTLFSEAIKVHpkGEAIMSPGglvkDP 262
Cdd:cd10325 155 GLALFAAAYSIYGGLKAVAWTDVIQVVFLVLGGLVTTYIALSLLgggegVFAGFTLLAAEAPEH--FHMILDKS----NP 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 263 ISAFSL--GFALMFGTAGLPH---------ILMRFFTVSDAKEARKSVFYAtGFIGyfYILTFIIGFGAIL-LVSTNPDF 330
Cdd:cd10325 229 EDAYKDlpGIAVLLGGLWVANlsywgfnqyIIQRALAAKSLSEAQKGIVFA-AFLK--LLIPFIVVIPGIAaYVLASNLL 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 331 KDATGALIGGNNMAAVHLADAVGGslFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASvFKGGKANEKDELRVSKMT 410
Cdd:cd10325 306 LPAATGIEKPDQAYPWLLRNLPTG--LKGLVFAALTAAIVSSLASMLNSISTIFTMDIYKK-YIPKKASEKQLVNVGRLA 382
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15598430 411 tvalGVVAIVLGILFEKQNIAFMVGLAF-----SIAASCNFPVLLLSMYWKKLTTRGAMIGGWMGLITAVGLMVLGPTI 484
Cdd:cd10325 383 ----AVIALIIAALIAPPLLGLDQAFQYiqeytGFISPGILAIFLLGLFWKRATSAGALVAAILSIVLSALFKFLLPEL 457
|
|
| SLC5sbd_SMIT |
cd11491 |
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT ... |
37-480 |
6.63e-04 |
|
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT is a high-affinity myo-inositol transporter, and is expressed in brain, heart, kidney, and lung. Inhibition of myo-inositol uptake, through down-regulation of SMIT, may be a common mechanism of action of mood stabilizers, including lithium, carbamazepine, and valproate. SMIT is encoded by the SLC5A3 gene, which is a candidate gene for pathogenesis of nervous system dysfunction in Down syndrome (DS). The SNP, 21q22 near SLC5A3-MRPS6-KCNE2, has been associated with coronary heart disease, cardiovascular disease, and myocardial infarction. SMIT may also be involved in the pathogeneisis of congenital cataract. SMIT also plays roles in osteogenesis, bone formation, and bone mineral density determination. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271382 Cd Length: 609 Bit Score: 42.55 E-value: 6.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 37 IVMFVAFVGATLCITYWA-SKRNRSA-ADYYAAGGRITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSIGFLVG 114
Cdd:cd11491 2 IAVVALYFILVMCIGIYAmWKSNRSTvSGYFLAGRSMTWLPVGASLFASNIGSEHFIGLAGSGAAAGFAVGAFEFNALIL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 115 WPIILFLIAERLRNLGKYTFADVASYRLKQKQIRTLSACGSLVVVAFYLIAQMVGAGKL-IELLFGLNYHVAVVLVGILM 193
Cdd:cd11491 82 LQLLGWVFIPVYIRSGVYTLPEYLSKRFGGHRIQVYLAALSLILYIFTKISVNLYSGALfIQEALGWNLYVSIILLLGLT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 194 VLYVLFGGMLATTWVQIIKAVLLLSGASFMAIMVLKHVNF--DVSTLFSEAIKVH------------------PKGEAIM 253
Cdd:cd11491 162 ALLTVTGGLAAVIYTDTLQAFLMIIGALTLMIISMMEIGGfeGVKSRYMLASPNVtsilltynlsntnsccvhPKKDAFK 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 254 spggLVKDPISAFS--LGFALMFGTAGLPH------ILMRFFTVSDAKEARKSVFYAtGFIGYFYILTFIIG-------F 318
Cdd:cd11491 242 ----LLRDPTDEDVpwPGFILGQTPASIWYwcadqvIVQRVLAAKSLSHAQGATLMA-GFIKLLPLFIIVIPgmisrilF 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 319 GAILLVSTNPDFKDATGALIGGNNMAAVHLADAVGGSLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVFKggKA 398
Cdd:cd11491 317 PDDIACINPEHCMQVCGSRAGCSNIAYPRLVMKIMPSGLRGLMMAVMIAALMSDLTSIFNSASTLFTLDVYKLIRK--KA 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 399 NEKDELRVSKMTTVALGVVAIV-LGILFEKQNIAFMVGLAfSIAASCNFPV---LLLSMYWKKLTTRGAMIGGWMGLITA 474
Cdd:cd11491 395 SSRELMIVGRIFVAVMVVISIAwIPVIQEMQGGQLYLYIQ-EVAAYLTPPVaslYLLAIFWKRTTEQGAFYGGMAGFVLG 473
|
....*.
gi 15598430 475 VGLMVL 480
Cdd:cd11491 474 AVRLIL 479
|
|
| SLC5sbd_NIS-SMVT |
cd11492 |
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ... |
38-487 |
1.06e-03 |
|
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (encoded by the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (encoded by the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and -2. SMCT1(encoded by the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (encoded by the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271383 [Multi-domain] Cd Length: 522 Bit Score: 41.70 E-value: 1.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 38 VMFVAFVGATLCI-TYWA--SKRNRSAADYYAAGGRITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSIGFLVG 114
Cdd:cd11492 4 VVFVAMLLISAAIgIYFGffGGKQKTTEEYLLGGRNMSVFPVALSLIASFISGITLLGTPAEIYYYGTQYWLIVIAYVLV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 115 WPIILFLIAERLRNLGkytfadVAS---Y---RLKQKqIRTLSACGSLVVVAFYL-IAQMVGAgklieLLF----GLNYH 183
Cdd:cd11492 84 GPITAYIFLPVFYNLQ------LTSvyeYlelRFNRR-VRLLASFLFILQMLLYLpIVIYAPA-----LALsqvtGINLH 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 184 VAVVLVGILMVLYVLFGGMLATTWVQIIKAVLLLsgASFMAIMVLKHVNfdvSTLFSEAIKVHPKGEAI----MSPGGLV 259
Cdd:cd11492 152 IIILVVGIVCIFYTTLGGLKAVVWTDVFQVVVMF--GGVLAVIILGTID---VGGFSEVWEIAEEGGRLeffnFDPDPTV 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 260 KDPISAFSLGFALMF--GTAGLPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGfgaILLVSTNPDFKDATGAL 337
Cdd:cd11492 227 RHTFWSLVIGGTFTWlsLYGVNQTQVQRYLSLPSLKSAKKALWLNIVGLILILSLCCFTG---LVIYAKYHDCDPLTAGL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 338 IGGNNMAAVHLADAVGGSL--FLG-FISAVAFATILAVVAGL-TLAgasAVSHDLYASVFKGGKANEKDELRVSKMTTVA 413
Cdd:cd11492 304 IKKPDQLLPYFVMDVLGHLpgLPGlFVAGIFSAALSTLSSGLnSLA---AVILEDFIKPFFKKKLSERQATNIMKLLVVV 380
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15598430 414 LGVVAIVLGILFEKQNiaFMVGLAFSIAASCNFPVL---LLSMYWKKLTTRGAMIGGWMGLITAVGLMVLGPTIWVQ 487
Cdd:cd11492 381 FGLLCIGLAFLVEKLG--GVLQLSLSIFGITGGPLLgifTLGMFFPWANSKGALVGLLVGLIFMLWIGIGGQIAIAP 455
|
|
| SLC5sbd_SGLT6 |
cd11490 |
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human ... |
33-220 |
1.33e-03 |
|
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human SGLT6 (also called KST1, SMIT2) is a chiro-inositol transporter, which also transports myo-inositol. It is encoded by the SLC5A11 gene. Xenopus Na1-glucose cotransporter type 1 (SGLT-1)-like protein is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271381 Cd Length: 602 Bit Score: 41.43 E-value: 1.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 33 NVSAIVMFVAFVGATLCITYWASKRNrSAADYYAAGGRITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSIG-- 110
Cdd:cd11490 1 DIVVLVLYFLFVLAVGLWSMWKTKRS-TVKGYFLAGKDMTWWPVGASLFASNVGSGHFIGLAGSGAAAGIGVVAYEWNgl 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598430 111 ---FLVGWPIILFLIAERLRNLGKYTfadvaSYRLKQKQIRTLSACGSLVVVAFYLIAQMVGAGKL-IELLFGLNYHVAV 186
Cdd:cd11490 80 fmvLVLAWLFLPIYIASRVTTMPEYL-----KKRFGGKRIQIFLAVLYLFIYIFTKISVDMYAGAVfIQQALQWDLYLAV 154
|
170 180 190
....*....|....*....|....*....|....
gi 15598430 187 VLVGILMVLYVLFGGMLATTWVQIIKAVLLLSGA 220
Cdd:cd11490 155 VGLLGITALYTVAGGLAAVIYTDALQTIIMVIGA 188
|
|
| |
