|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
16-415 |
1.40e-75 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 241.88 E-value: 1.40e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 16 PLSPYHRLVFVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASI 95
Cdd:TIGR00895 10 PLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 96 VLWGLASYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTG 175
Cdd:TIGR00895 90 LLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 176 WRSIFLV-LALPAVFVLAIRFLIPESPRWLeQAGRREQADRVLRDIEARVMRSlGLTELPPPLRQPQRERsrpgffSAFA 254
Cdd:TIGR00895 170 WRSLFYVgGIAPLLLLLLLMRFLPESIDFL-VSKRPETVRRIVNAIAPQMQAE-AQSALPEQKSTQGTKR------SVFK 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 255 ELWSPAYRRRTLTVWGLWFFALLGFYGLTSWLSALLQQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPSCVLm 334
Cdd:TIGR00895 242 ALFQGKTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALL- 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 335 LLGGGAMAYAYGQTAvfgGSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLV 414
Cdd:TIGR00895 321 LLLGAVFAVLVGSTL---FSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYL 397
|
.
gi 15598663 415 L 415
Cdd:TIGR00895 398 L 398
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
25-440 |
5.08e-65 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 212.85 E-value: 5.08e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 25 FVIIALAFFFDSMDLAMMTFLLGSIKAEF--GLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLAS 102
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFslGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 103 YLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLT----GWRS 178
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgdwGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 179 IFLVLALPAVFVLAIrflipesprwleqagrreqadrvlrdiearvmrslgltelppplrqpqrersrpgffsafaelws 258
Cdd:cd17316 161 LFLIGALPALLALLL----------------------------------------------------------------- 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 259 payRRRTLTVWGLWFFALLGFYGLTSWLSALLQQ-SGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPSCVLMLLG 337
Cdd:cd17316 176 ---RRRTLLLILLWFFISFGYYGLTTFLPTYLQTvLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLIL 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 338 GGAMAYAYGQtaVFGGSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLVLPL 417
Cdd:cd17316 253 SGILALPLFY--LLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAS 330
|
410 420
....*....|....*....|...
gi 15598663 418 TGQGGVFTLGALCFGVAALVVWA 440
Cdd:cd17316 331 TGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
25-446 |
1.31e-60 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 202.53 E-value: 1.31e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 25 FVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYL 104
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 105 CSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPL----TGWRSIF 180
Cdd:cd17371 81 CGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLlppeIAWRVLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 181 LVLALPAVFVLAIRFLIPESPRWLE-QAGRREQADRVlrdiearvmrslgltelppplrqpqrersrpgffsAFAELWSP 259
Cdd:cd17371 161 LLGALPALLVLFIRRFVKEPPQWQAaRAARRHFADRP-----------------------------------SLRELFSP 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 260 AYRRRTLTVWGLWFFALLGFYGLTSWLSALL-QQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPSCVLMLLGG 338
Cdd:cd17371 206 PLLRTTLLASLLATGALGGYYGITTWLPSYLtGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGS 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 339 GAMAYAYGQtavFGGSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLVLPLT 418
Cdd:cd17371 286 AISILLYFF---LPLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSG 362
|
410 420
....*....|....*....|....*...
gi 15598663 419 GQGGVFTLGALcFGVAALVVWAFGIETR 446
Cdd:cd17371 363 SLGTAIAVFAA-VYYIAGLVLALLLPET 389
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
18-446 |
3.57e-54 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 184.69 E-value: 3.57e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 18 SPYHRLVFVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVL 97
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 98 WGLASYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWR 177
Cdd:COG2271 85 WGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 178 SIFLVLALPAVFVLAIRFLIpesprwleqagrreqadrvlrdiearvmrslgltelppplrqpqrersrpgffsafaelw 257
Cdd:COG2271 165 AAFLILGLPGLLLALLRFWL------------------------------------------------------------ 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 258 spayrrrtltVWGLWFFALLGFYGLTSWLSALLQQS-GFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPSCVLMLL 336
Cdd:COG2271 185 ----------LALAYFLVYFALYGFLTWLPTYLVEVrGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIG 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 337 GGGAMAYAYGqtAVFGGSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLVLP 416
Cdd:COG2271 255 LLLAALALLL--LALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLD 332
|
410 420 430
....*....|....*....|....*....|
gi 15598663 417 LTGQGGVFTLGALCFGVAALVVWAFGIETR 446
Cdd:COG2271 333 ATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
28-438 |
4.46e-54 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 184.33 E-value: 4.46e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 28 IALAFF---FDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYL 104
Cdd:cd17365 1 LALCFLiivLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 105 CSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFLVLA 184
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 185 LPAVFVLAIrflipesprwleqagrreqadrvlrdiearvmrslgltelppplrqpqrersrpgffsafaelwspayRRR 264
Cdd:cd17365 161 VPPLILLPL--------------------------------------------------------------------LRG 172
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 265 TLTVWGLWFFALLGFYGLTSWLSALLQQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPSCVLMLLGGGAMAYA 344
Cdd:cd17365 173 TLLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLAL 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 345 ygqTAVFGGSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLVLPLTGQ-GGV 423
Cdd:cd17365 253 ---LGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGpESV 329
|
410
....*....|....*
gi 15598663 424 FTLGALCFGVAALVV 438
Cdd:cd17365 330 FLALAIPAALGALAV 344
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
24-440 |
6.88e-47 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 166.68 E-value: 6.88e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 24 VFVIIALAFF---FDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGL 100
Cdd:PRK11551 13 LALTIGLCFLvalLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 101 ASYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIF 180
Cdd:PRK11551 93 FSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 181 LVLAL-PAVFVLAIRFLIPESPRWLEQAGRREQadrvlrdiearvmrslgltelppplrqpqrersRPGFFSAfaeLWSP 259
Cdd:PRK11551 173 YVGGVgPLLLVPLLMRWLPESRAFAQAAGAGKQ---------------------------------RAPVLRA---LFGE 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 260 AYRRRTLTVWGLWFFALLGFYGLTSWLSALLQQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPSCVLMLLGgg 339
Cdd:PRK11551 217 GRATATLLLWISYFFTLIVLYFLLNWLPSLLVGQGLSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPRRVVLLIYAG-- 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 340 aMAYAYGQTAVFGGSLALLIGfGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLVLPLtG 419
Cdd:PRK11551 295 -ILASLAALAAAPSFAGMLLA-GFAAGLFVVGGQSVLYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAGQLLAL-G 371
|
410 420
....*....|....*....|...
gi 15598663 420 QGGVFTLGALCFG--VAALVVWA 440
Cdd:PRK11551 372 RSTVGVIGASIPVilVAALAALL 394
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
35-452 |
4.81e-46 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 166.73 E-value: 4.81e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 35 DSMDLAMMTFLlGSIKAEFGL---DSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDL 111
Cdd:TIGR00898 102 DGWEYSYDTFS-STIVTEWDLvceDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNY 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 112 DSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPltgWRSIFLVLALPAVFVL 191
Cdd:TIGR00898 181 TVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPD---WRWLQLAVSLPTFLFF 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 192 AIRFLIPESPRWLEQAGRREQADRVLRDIEARVMRSLGLTELPPPLRqpQRERSRPGFFSAFAELWSPAYRRRTLTVWGL 271
Cdd:TIGR00898 258 LLSWFVPESPRWLISQGRIEEALKILQRIAKINGKKLPAEVLSLSLE--KDLSSSKKQYSFLDLFRTPNLRKTTLCLMML 335
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 272 WFFALLGFYGLTSWLSALlqqsgfavTQSVYYTVLIS-LAGIPGFLCAAWLVESWGRKPSCVLMLLGGGAMAYAYGqtAV 350
Cdd:TIGR00898 336 WFTTAFSYYGLVLDLGNL--------GGNIYLDLFISgLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLL--FV 405
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 351 FGGSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGL-----VLPLtgqgGVFT 425
Cdd:TIGR00898 406 PVDLYFLRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVYLgekwlFLPL----VLFG 481
|
410 420
....*....|....*....|....*..
gi 15598663 426 LGALCFGVAALvvwaFGIETRGRTLEE 452
Cdd:TIGR00898 482 GLALLAGILTL----FLPETKGVPLPE 504
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
50-453 |
4.79e-40 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 149.34 E-value: 4.79e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 50 KAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDS---LTFYRVLLGIGMG 126
Cdd:pfam00083 38 VSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSvyqLIVGRVLVGIGVG 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 127 MEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLL---PLTGWRSIFLVLALPAVFVLAIRFLIPESPRW 203
Cdd:pfam00083 118 GASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNktsNSDGWRIPLGLQLVPALLLIIGLLFLPESPRW 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 204 LEQAGRREQADRVLRDIEARVMRSLGLTELPPPLrqpqrERSRPGFFSAFAELWS-PAYRRRTLTVWGLWFFA-LLGFYG 281
Cdd:pfam00083 198 LVEKGRLEEAREVLAKLRGVPDVDRELDEIKDSL-----EAGQEAEKASWKELFStKTRRQRLLIGVMLQIFQqLTGINA 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 282 LTSWLSALLQQSGFavTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPSCVLMLLGGGAMAYAYGQTAVFG----GSLAL 357
Cdd:pfam00083 273 IFYYSTTIFENLGL--SDSFLVTIIVGVVNFVFTFIAIFLVDRFGRRPLLLLGAAGMAICFVILGIVALLGvsksDWAGI 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 358 LIGFGLAMQFFLFGM-WA-VLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLVLPLTGQGGVFTLGALCFGVAA 435
Cdd:pfam00083 351 VAIVFIALFIAFFAMgWGpVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFI 430
|
410
....*....|....*...
gi 15598663 436 LVVWAFGIETRGRTLEEL 453
Cdd:pfam00083 431 IFVFFFVPETKGRTLEEI 448
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
18-404 |
2.69e-39 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 144.73 E-value: 2.69e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 18 SPYHRLVFVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVL 97
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 98 WGLASYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWR 177
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 178 SIFLVLALPAVFVL-AIRFLIPESPRwleqagrreqadrvlrdiearvmrslgltelppplrqpqreRSRPGFFSAFAEL 256
Cdd:COG2814 165 WVFLVNAVLALLALlLLLRLLPESRP-----------------------------------------AARARLRGSLREL 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 257 WSpayRRRTLTVWGLWFFALLGFYGLTSWLSALLQQ-SGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPSCVLML 335
Cdd:COG2814 204 LR---RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGL 280
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15598663 336 LGGGAMAYAYGqtavFGGSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGS 404
Cdd:COG2814 281 LLLALGLLLLA----LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
19-448 |
6.32e-37 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 139.25 E-value: 6.32e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 19 PYHRLVFVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLW 98
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 99 GLASYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRS 178
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 179 IFLVLALP-AVFVLAIRFLIPESPRWLEQAGRreqadrvlrdiearvmrslgltelppplrqpqrersrpgffSAFAELW 257
Cdd:COG2223 161 AFLILGILlLVVAVLAWLFLRDPPAGAAAAAK-----------------------------------------ASLRDQL 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 258 SPAYRRRTLTVWGLWFFALLGFYGLTSWLSALLQ-QSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPSCVLMLL 336
Cdd:COG2223 200 EALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVdQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFA 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 337 GGGAMAYAygqTAVFGGSLALLIGFGLAMqFFLFGMW-AVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLVL 415
Cdd:COG2223 280 LMALGLLL---LALALGSLWLFLVLFLLL-GLALGGGnGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALL 355
|
410 420 430
....*....|....*....|....*....|....
gi 15598663 416 PLTGQ-GGVFTLGALCFGVAALVVWAFGIETRGR 448
Cdd:COG2223 356 DATGSyTAAFLVFAVLALVALVLTLLLYRRPRRA 389
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
54-453 |
3.71e-35 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 136.31 E-value: 3.71e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 54 GLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLW---GLASYLCSTAGDLDSLTFYRVLLGIGMGMEFP 130
Cdd:TIGR00879 67 SYSSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFvigAILMGLAAFALSVEMLIVGRVLLGIGVGIASA 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 131 IAQSLLSEMIPASRRGKYIALMDGFWPLG-FVAAGCLSYFLLPLT--GWRSIFLVLALPAVFVLAIRFLIPESPRWLEQA 207
Cdd:TIGR00879 147 LVPMYLSEIAPKALRGALTSLYQLAITFGiLVAYGFGSGKVSLNNtlGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGK 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 208 GRREQADRVLRDI------EARVMRSLGLTELPPPLRQPQRERSRPGFFSafaelWSPAYRRRTLTVWGL-WFFALLGFY 280
Cdd:TIGR00879 227 GRVEEARKSLARLrgtsgeDKELLDELELIDIKRSIEKRSVQPSWGSLFS-----STRRIRRRLFLGVVLqWFQQFTGIN 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 281 GLTSWLSALLQQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKP-------SCVLMLLGGGAMAYAYGQTAVFGG 353
Cdd:TIGR00879 302 AIMYYSPTIFENAGVSTDHAFLVSIIVGAVNFAFTFVAIFLVDRFGRRPllligaaGMAICLFVLGILGASFVTGSSKSS 381
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 354 SLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLVLPLTGQGGVFTL-GALCFg 432
Cdd:TIGR00879 382 GNVAIVFILLFIAFFAMGWGPVPWVIVSEIFPLSLRPKGISIAVAANWLANFIVGFLFPTMLESIGVGGVFIFfGGLNV- 460
|
410 420
....*....|....*....|.
gi 15598663 433 VAALVVWAFGIETRGRTLEEL 453
Cdd:TIGR00879 461 LGLIFVYFFLPETKGRTLEEI 481
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
52-452 |
4.98e-34 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 132.31 E-value: 4.98e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 52 EFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVLLGIGMGMEFPI 131
Cdd:cd17358 35 SLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 132 AQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLlpltGWRSIFLVLALPAVFVLAIRFLIPESPRWLEQAGRRE 211
Cdd:cd17358 115 VPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFL----PWRTLALIGAIPPVVFLILLFFIPESPRWLAKKGREE 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 212 QADRVL---RDIEARVMRslgltELPPPLRQPQRERSRPGFFSaFAELWSPAYRRRTLTVWGLWFFALL-GFYGLTSWLS 287
Cdd:cd17358 191 EAEKSLqflRGKDADISK-----EAAEIQEELAELEKEAKESS-FSDLFQRKYLKPLVIGLGLMLFQQLsGINAVIFYAS 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 288 ALLQQSGfAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKP----SCVLMLLGGGAMA--YAYGQTAVFGGSLALLIGF 361
Cdd:cd17358 265 SIFDEAG-SGLDPNTATIIIGVVQVVGTLVATLLVDRLGRRPlllvSAIGMGIGLLALGlyFYLQEHGALLSSVSWLPLV 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 362 GLAMQFFLF--GMWAVLYTYTPELYPTSARATGSGFASAVgriGSLLGPLVTGLVLPLT---GQGGVFTLGALCFGVAAL 436
Cdd:cd17358 344 GLVIYIISFsiGLGPLPWVIMSEIFPAKIKGLAGSLVTLV---NWLFAFIVTKTFPFLTlawGASGTFWIFAGICGLALV 420
|
410
....*....|....*.
gi 15598663 437 VVWAFGIETRGRTLEE 452
Cdd:cd17358 421 FVLLFVPETKGKSLEE 436
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
46-441 |
4.46e-32 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 125.76 E-value: 4.46e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 46 LGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVLLGIGM 125
Cdd:cd17359 24 LPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 126 GMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLP--------LTGWRSIFLVLALPAVFVLAIRFLI 197
Cdd:cd17359 104 GGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANaggadwlgAEGWRWMLGLEAIPAILFLLGMLFI 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 198 PESPRWLEQAGRReqadrvlrdieaRVMRSLGLtelppplrqpqrersrpGFFSAFAELWSPAYrrrtltvwglwffall 277
Cdd:cd17359 184 PESPRWLVSKGKP------------ILIIGIGL-----------------AIFQQFVGINVIFY---------------- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 278 gfYGltswlSALLQQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPscvLMLLGGGAMAYAYGQTAVFGGSLAL 357
Cdd:cd17359 219 --YG-----PEIFQNAGFSENAALLQTIGIGVVNVIFTIIAILLVDKVGRKP---LLLIGSIGMAISLLLIGTAFYFAPG 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 358 --------LIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLVLPLTGQGGVFTLGAL 429
Cdd:cd17359 289 sqasgivaLVLILLFVAFFAMSWGPVTWVLLSEIFPNRIRGLAMGIAVFFLWIANFLVSLTFPILLAAFGLAFTFLIFAV 368
|
410
....*....|..
gi 15598663 430 CFGVAALVVWAF 441
Cdd:cd17359 369 ICVLAFLFVWKF 380
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
24-306 |
7.35e-32 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 128.94 E-value: 7.35e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 24 VFVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASY 103
Cdd:TIGR01299 168 LFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAF 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 104 LCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTG-------- 175
Cdd:TIGR01299 248 FSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPHYGwsfqmgsa 327
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 176 -----WRSIFLVLALPAVFVLAIRFLIPESPRWLEQAGRREQADRVLRDIEARVMRSLGLTE---LPPPLRQPQRE---- 243
Cdd:TIGR01299 328 yqfhsWRVFVIVCAFPCVFAIGALTFMPESPRFFLENGKHDEAWMILKLIHDTNMRAKGHPEkvfSVNHIKTIHQEdeli 407
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 244 ---------------RSRP---GFFSAFAELWSPAYRRRTLTVWGLWFFALLGFYGLTSWLSALLQQsgfavTQSVYYTV 305
Cdd:TIGR01299 408 eiesdtgtwyqrcfvRALSeggGIWGNFLRCFNPEVREITIKLMGVWFTLSFGYYGLSVWFPDMIKH-----LQADDYAA 482
|
.
gi 15598663 306 L 306
Cdd:TIGR01299 483 L 483
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
25-418 |
2.74e-31 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 125.29 E-value: 2.74e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 25 FVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYL 104
Cdd:cd17363 1 FFVLGLALMADGVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 105 CSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTG--------- 175
Cdd:cd17363 81 SSFVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSWLCMFWMIGGLYASAMAWAIIPHYGwgfsmgtay 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 176 ----WRSIFLVLALPAVFVLAIRFLIPESPRWLEQAGRREQADRVLRDIEARVMRSLGltelppplrQPQRersrpgFFS 251
Cdd:cd17363 161 qfhsWRVFVIVCALPSVASVVALTFMPESPRFLLEVGKHDEAWMILKQVHDTNMRAKG---------HPER------VFT 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 252 AfaelwSPAYRRRTLTVWGLWFFALLGFYGLTSWLSALLQQSGF-----------------------AVTQSVYY----- 303
Cdd:cd17363 226 V-----SHIKRMNTLFLAIVWFTMSFSYYGLTVWFPDMIKYLQFedslfeecyfedvtstntffencTFINTVFYntdlf 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 304 -------------------------------------TVLISLAGIPGFLCAAWLVESWGRkpscvLMLLGGGAMAYAYG 346
Cdd:cd17363 301 eykfidsrflnstfflkekcgchlnddeenayliylvSFLGSLSVLPGNIVSALLMDKIGR-----LKMIGGSMLLSAVC 375
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15598663 347 QTAV-FGGSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLVLPLT 418
Cdd:cd17363 376 CFFLfFGNSESAMIGLQCLFCGVSIAAWNALDVVTVELYPTDKRATAFGFLNGLCKLAAILGNSIFGSFVGIT 448
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
8-455 |
5.13e-31 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 124.84 E-value: 5.13e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 8 AAERLERLPLSPYHRLVFVIIALAFFFDSMDL---AMMTFLLGSI--KAEFGLDSAQAGLLASSSFFGMVIGAALSGMLA 82
Cdd:TIGR00887 1 ALEEADTAPFGWQHFRAIVIAGVGFFTDSYDLfciSLVTKMLGYVyyHGKGPLPSSVSAAVNGSASIGTLAGQLFFGWLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 83 DRFGRKPVFQASIVLWGLASYLCSTAGDLDS------LTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFW 156
Cdd:TIGR00887 81 DKLGRKRVYGMELIIMIIATVASGLSPGSSPksvmatLCFWRFWLGVGIGGDYPLSAIITSEFATKKWRGAMMAAVFAMQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 157 PLGFVAAGCLSYFLL--------------PLTG---------WRSIFLVLALPAVFVLAIRFLIPESPRWLEQAGRR-EQ 212
Cdd:TIGR00887 161 GFGILAGAIVALIVLagfkhsleaaadeaSCTGscvpavdymWRILIGFGAVPALLALYFRLTIPETPRYTADVAKDvEQ 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 213 ADrvlRDIEARVMRSL-----GLTELPPPLRQPQRERSrpGFFSAFAeLWSpaYRRRTLTVWGLWFFALLGFYGLTSWLS 287
Cdd:TIGR00887 241 AA---SDMSAVLQVKIeaepdEVEKASTAVEVPKASWS--DFFTHFF-KWR--HGKHLLGTAGSWFLLDIAFYGVNLNQK 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 288 ALLQQSGFAVT-------QSVYYT----VLISLAG-IPGFLCAAWLVESWGRKPscvLMLLGGG-------AMAYAYGQT 348
Cdd:TIGR00887 313 VILSAIGYSPPaatnnayEELYKTavgnLIIALAGtVPGYWVTVFLVDIIGRKP---IQLMGFFiltvlffVLGFAYNHL 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 349 avfgGSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGplvTGLVLPLTGQGGVFTLGA 428
Cdd:TIGR00887 390 ----STHGFLAIYVLAQFFANFGPNATTFIVPGEVFPTRYRSTAHGISAASGKAGAIIG---QFGFLYLAQHGDPTKGYP 462
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 15598663 429 LCFGVAAlVVWAFGI-------------ETRGRTLEELAG 455
Cdd:TIGR00887 463 TGIWMGH-VLEIFALfmflgilftllipETKGKSLEELSG 501
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
28-408 |
1.10e-30 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 121.37 E-value: 1.10e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 28 IALAFFFDSMDLAM-MTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCS 106
Cdd:pfam07690 1 LFLAAFLAALGRSLlGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 107 TAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFLVLALP 186
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 187 AVFVLAIRFlipesprwleqagrreqadrvlrdiearvmrslglteLPPPLRQPQRERSRPGFFSAFAELWSPAYRRRTL 266
Cdd:pfam07690 161 SLLAAVLLL-------------------------------------LPRPPPESKRPKPAEEARLSLIVAWKALLRDPVL 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 267 TVWGLWFFALLGFYGLTSWLSALLQQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPSCVLMLLGGGAMAYAYG 346
Cdd:pfam07690 204 WLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLL 283
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15598663 347 QTAVFGGSLALLIGFgLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGP 408
Cdd:pfam07690 284 LLSLTLSSLWLLLAL-LLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
18-305 |
2.76e-30 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 119.15 E-value: 2.76e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 18 SPYHRLVFVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVL 97
Cdd:COG0477 9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 98 WGLASYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWR 177
Cdd:COG0477 89 FGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 178 SIFLVLALPAVFVLAIRFLIPESpRWLEQAGRREQADRVLRDIEARVMRSLGLTELPPPLRQPQRERSRPGFFSAFAELW 257
Cdd:COG0477 169 WIFLINAPLGLLALVLRLRLPES-RGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLL 247
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 15598663 258 SPAYRRRTLTVWGLWFFALLGFYGLTSWLSALLQQSGFAVTQSVYYTV 305
Cdd:COG0477 248 LALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
22-440 |
1.19e-29 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 118.44 E-value: 1.19e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 22 RLVFVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLA 101
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 102 SYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFL 181
Cdd:cd17319 82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 182 VLALPAVfvlairflipesprwleqagrreqadrvlrdiearvmrslgltelppplrqpqrersrpgffsafaeLWSPAY 261
Cdd:cd17319 162 IEGLLGL-------------------------------------------------------------------LLAVLW 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 262 RRRTLTVWGL---WFFALLGFYGLTSWLSALLQQS-GFAVTQSVYYTVLISLAGIPGFLCAAWLVE---SWGRKPSCVLM 334
Cdd:cd17319 175 WFYLRQVWGLalgYFGINYALYGLLTWLPTYLKQArGFSLKQVGLLAAIPFLAGAIGMILGGRLSDrllRGARRLVIIIG 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 335 LLGGGAMAYAygqtAVFGGSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLV 414
Cdd:cd17319 255 LLLAAVGLLL----AYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYL 330
|
410 420
....*....|....*....|....*..
gi 15598663 415 LPLTG-QGGVFTLGALCFGVAALVVWA 440
Cdd:cd17319 331 VDATGsYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
28-441 |
1.83e-29 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 118.45 E-value: 1.83e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 28 IALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCST 107
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 108 AGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFLVLALPA 187
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 188 VFVLAIRFLIPESPRwleqagrreqadrvlrdiearvmrslgltelppplrqPQRERSRPGFFSAFAELWSPAYRRRTLT 267
Cdd:cd17325 161 LLALVLALLLLPEPR-------------------------------------PPPNKRAVSAARLRSGLRLLLRDRRLLA 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 268 VWGLWFFALLGFYGLTSWLSALLQQSGFAVTQSVyyTVLISLAGIPGFLCAA---WLVESWGRKPSCVLMLLGGGAMAYA 344
Cdd:cd17325 204 LFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQI--GLLFGAQGLASALSQPpagKLSDRIGRKPLILIGLLLSAVALLL 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 345 YGQTAVFGGSLALLIGFGLAMQFflfgMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLVLPLTGQGGVF 424
Cdd:cd17325 282 LPLATSFWLLLLLLALLGLGLGL----VFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPF 357
|
410
....*....|....*..
gi 15598663 425 TLGALCFGVAALVVWAF 441
Cdd:cd17325 358 LAAAALLLLAAVLFLLL 374
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
25-441 |
2.88e-29 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 117.64 E-value: 2.88e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 25 FVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYL 104
Cdd:cd17372 1 LAYAGMGWVAEAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 105 CSTAGDLDSLTFYRVLLGIGMGmEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFLVLA 184
Cdd:cd17372 81 SAFAPNYMWLIILRCLVGLGLG-GGPQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 185 LPAVFVLAIRFLIPesprwleqagrreqadrvlrdiearvmrslgltelppplrqpqrersrpgffsafaelwspayrRR 264
Cdd:cd17372 160 VPSSLLLVFYRWTP----------------------------------------------------------------KT 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 265 TLTVWGLWFFALLGFYGLTSWLSALLQ-----------QSGFAVTQ--------SVYYTVLI-SLAGIPGFLCAAWLVES 324
Cdd:cd17372 176 TLLLWVIWFGNAFAYYGVVLLTTELNNshnvcgsksdsDSGESPTEkqcrnsndVDYRDVFIaTFAEFPGLLISAAMIDR 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 325 WGRKPScvlmllgggaMAYAYGQTAVFG------GSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASA 398
Cdd:cd17372 256 LGRKAS----------MASMLFTCCIFLllllicQSPFILTVLLFGGRACISAAFTVVYIYTPEVYPTAVRALGVGTGSS 325
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 15598663 399 VGRIGSLLGPLVTgLVLPLTGQGGVFTLGALCFGVAALVVWAF 441
Cdd:cd17372 326 VGRIGAILCPFIA-QVLVHGSQTIALLLFSVVCLVSAICVCLL 367
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
25-407 |
5.74e-29 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 118.59 E-value: 5.74e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 25 FVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYL 104
Cdd:cd17439 1 YFVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 105 CSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTG--------- 175
Cdd:cd17439 81 SSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGwsfqmgsay 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 176 ----WRSIFLVLALPAVFVLAIRFLIPESPRWLEQAGRREQADRVLRDIEARVMRSLGltelppplrQPQRersrpgFFS 251
Cdd:cd17439 161 qfhsWRVFVLVCAFPSVFAIGALTTMPESPRFFLENGKHDEAWMVLKQVHDTNMRAKG---------HPER------VFS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 252 AfaelwSPAYRRRTLTVWGLWFFALLGFYGLTSWL---------SALLQQSGFA------VTQS---------------- 300
Cdd:cd17439 226 V-----THIKRRITLMMMAVWFTMSFSYYGLTVWFpdmikhlqkSVVFEDSLFEecyfedITSSntffknctfistlfyn 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 301 -------------------------------------VYY-TVLISLAGIPGFLCAAWLVESWGRkpscVLMLLGGGAMA 342
Cdd:cd17439 301 tdlfeykfinsklinstflhnkegclldfsdennaymIYFvSFLGTLAVLPGNIVSALLMDKIGR----LRMLAGSSVMS 376
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15598663 343 YAYGQTAVFGGSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLG 407
Cdd:cd17439 377 CVSCFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLG 441
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
25-407 |
5.84e-29 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 118.49 E-value: 5.84e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 25 FVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYL 104
Cdd:cd17438 1 FFVLGLALMADGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 105 CSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTG--------- 175
Cdd:cd17438 81 SSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIPHYGwgfsmgtny 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 176 ----WRSIFLVLALPAVF-VLAIRFLiPESPRWLEQAGRREQADRVLRDIEARVMRSLGLTELppplrqpqrersrpgFF 250
Cdd:cd17438 161 hfhsWRVFVIICALPCIAsIIALKFM-PESPRFLLEMGKHDEAWMILKNIHDTNMRAKGTPEK---------------VF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 251 SAfaelwSPAYRRRTLTVWGLWFFALLGFYGLTSWL---------SALLQQSGF------------------AVTQSVYY 303
Cdd:cd17438 225 TV-----SNIKRKNTLFLAVVWFTMAFSYYGLTVWFpdmirylqkHVTFEDSLFdecyfedvtstdtyfkncTIESTIFY 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 304 -----------------------------------------TVLISLAGIPGFLCAAWLVESWGRkpscvLMLLGGGAMA 342
Cdd:cd17438 300 ntdlyehkfidcrfinstfleqkegchmdfeedndfliylvSFLGSLSVLPGNIISALLMDKIGR-----IKMIGGSMLI 374
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15598663 343 YAYGQTAV-FGGSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLG 407
Cdd:cd17438 375 SAVCCFFLfFGNSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNKRATAFGILNGLCKFAAILG 440
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
26-429 |
2.26e-28 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 115.30 E-value: 2.26e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 26 VIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLC 105
Cdd:cd17441 2 ILTGLAWMADAMEMMILSILAPQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 106 STAGDLDSLTFYRVLLGIGMGMeFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFLVLAL 185
Cdd:cd17441 82 AFAPIYSWILVLRGLVGFGIGG-VPQSVTLYAEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 186 PAVFVLAIRFLIPESPRWleqagrreqadrvlrdiearvmrslgltelppplrqpqrersrpgffsafaelwspayrRRT 265
Cdd:cd17441 161 PLLIFAVLCFWLPESARY-----------------------------------------------------------WTT 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 266 LTVWGLWFFALLGFYGLTSWLSALLQQSGFA------------------VTQSVYYTVL-ISLAGIPGFLCAAWLVESWG 326
Cdd:cd17441 182 ILLWFIWFSNAFSYYGLVLLTTELFQAGDVCsgssgkkvegkcsleceyLTTSDYMDLLwTTLSEFPGLLVTLWIIDRFG 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 327 RKPScvlmllgggaMAYAYGQTAVFGGSLALLIG------FGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVG 400
Cdd:cd17441 262 RKKT----------MALCFFVFSFCTLLLFSCVGrfsltvLLFIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMA 331
|
410 420 430
....*....|....*....|....*....|....*
gi 15598663 401 RIGSLLGPLV------TGLVLPLTGQGGVFTLGAL 429
Cdd:cd17441 332 RVGALITPFIaqvmleSSVYLTLSVYSGCCLLAAI 366
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
30-439 |
6.54e-27 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 111.66 E-value: 6.54e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 30 LAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAG 109
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 110 DLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFLVLALPAVF 189
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 190 VLAIRFLI----PESPRWLEQAGRREQADRVLRDIEARVMRSLGLTELPPPLRQpqrersrpgffsafaelwspayrRRT 265
Cdd:TIGR00893 161 WGVLWLKFipdpPQKAKWLTEEEKYIVVGGLLAEQQGKGPSTPKKYQIKELLKD-----------------------RRV 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 266 LTVWGLWFFALLGFYGLTSWLSALLQQS-GFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKP-----SCVLMLLGGG 339
Cdd:TIGR00893 218 WGLALGQFLVNIGLGFFLTWFPTYLVQErGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGkslvfARKTAIIAGL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 340 AMAYAYGQTAVFGGSLALLIGFGLAmqFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLVLPLTG 419
Cdd:TIGR00893 298 VLSLLMFATNYVNIPYAALALVALG--FFGLGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTG 375
|
410 420
....*....|....*....|.
gi 15598663 420 Q-GGVFTLGALCFGVAALVVW 439
Cdd:TIGR00893 376 SfAGALMVVAALALIGALSYL 396
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
25-418 |
9.82e-27 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 112.31 E-value: 9.82e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 25 FVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYL 104
Cdd:cd17440 1 FFVLGMALMADGVEVFVVGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 105 CSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTG--------- 175
Cdd:cd17440 81 SSFVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGwsfsmgsay 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 176 ----WRSIFLVLALPAVFVLAIRFLIPESPRWLEQAGRREQADRVLRDIEARVMRSLGltelppplrQPQRersrpgFFS 251
Cdd:cd17440 161 qfhsWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKQIHDTNMRARG---------QPEK------VFT 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 252 AfaelwSPAYRRRTLTVWGLWFFALLGFYGLTSWLSALLQ---------------------------------------- 291
Cdd:cd17440 226 V-----NRIKKDNTIKLTIVWLTLSFGYYGLSVWFPDVIKhlqfksvtfedslfkscffedvtsvntyfrnctfietvfy 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 292 --------------------------QSGFAVTQSVYYTVLI----SLAGIPGFLCAAWLVESWGRkpscvLMLLGGGAM 341
Cdd:cd17440 301 ntdledykfidsdfinctffhnktgcQITFDDDYSAYWIYFVnflgTLAVLPGNIVSALLMDRIGR-----LTMLGGSMV 375
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15598663 342 AYAYGQTAV-FGGSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLVLPLT 418
Cdd:cd17440 376 LSGISCFFLwFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVGIT 453
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
61-448 |
1.34e-26 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 111.58 E-value: 1.34e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 61 GLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLAS---YLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLS 137
Cdd:cd17357 52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSllmFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQ 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 138 EMIPASRRGkyiaLMDGFWPLGF-----VAAGC-LSYFLLPLTGWRSIFLVLALPAVFVLAIRFLIPESPRWL-EQAGRR 210
Cdd:cd17357 132 EISPSELRG----ALGSLTQIGVtlgilLGQVFgLPSVLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFLlISKGDE 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 211 EQADR---VLRDIEARVMRSLgltelpPPLRQPQRERSRPGFFSAFAELWSPAYRRRTLTVWGLWFF-ALLGFYGLTSWL 286
Cdd:cd17357 208 EEAEKslkFLRGIEDDVDQEL------EEIKKESEQMGDQKQVSLMQLLRDPSLRLPLLLVLVVSASqQFSGINAIFFYS 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 287 SALLQQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKP-------SCVLMLLGGGAMAYAYGQTAVFG-GSLALL 358
Cdd:cd17357 282 TFIFENAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPlllislsVCAVALLLMSVFLFLSEQNSWMSyGCIVAI 361
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 359 IGFGLamqFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLlgpLVTGLVLPLTGQGG--VFTLGALCFGVAAL 436
Cdd:cd17357 362 FLFIF---FFAIGLGPIPWFIGAELFPQAPRSAAQSLGSSVNWTSNF---IVGMAFPPLQSIGGgfVFIIFAIPCALFLL 435
|
410
....*....|..
gi 15598663 437 VVWAFGIETRGR 448
Cdd:cd17357 436 YLYRYLPETKGR 447
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
48-436 |
6.28e-26 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 107.67 E-value: 6.28e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 48 SIKAEFGLDSAQAGLLASSS---FFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVLLGIG 124
Cdd:cd17317 12 TIVTEWDLVCDRDWLVALVQtifFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVT 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 125 MGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLlplTGWRSIFLVLALPAVFVLAIRFLIPesprwl 204
Cdd:cd17317 92 SAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLI---RDWRWLQLAISLPGLLFLLLLWWLP------ 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 205 eqagrreqadrvlrdiearvmrslgltelppplrqpqrersrpgffsafaelwspayrRRTLTVWGLWFFALLGFYGLTs 284
Cdd:cd17317 163 ----------------------------------------------------------RRTIIVGLIWFVTSLVYYGLS- 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 285 wlsalLQQSGFAVTQSVYyTVLISLAGIPGFLCAAWLVESWGRKPS-CVLMLLGGGAMAYAYgqtAVFGGSLALLIGFGL 363
Cdd:cd17317 184 -----LNSSNLGGNLYLN-FFLSGLVEIPAYFLALLLLDRLGRRWTlSGSLLLAGLACLVTA---LLPDDENTLALTLAL 254
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15598663 364 AMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVT-----GLVLPLTgqggVFTLGALCFGVAAL 436
Cdd:cd17317 255 VGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVllgkiGPLLPLI----IFGVLALLGGLLTL 328
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
17-448 |
1.26e-25 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 109.02 E-value: 1.26e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 17 LSPYHRLVFVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIV 96
Cdd:PRK03893 14 LNRAQWKAFSAAWLGYLLDGFDFVLITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 97 LWGLASYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGW 176
Cdd:PRK03893 94 LFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGW 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 177 RSIFLVLALPAVFVLAIRFLIPESPRWLEQAGRREqADRVLRDIEARVMRSL---GLTELppplrqpqrersrpgffsAF 253
Cdd:PRK03893 174 RALFFIGILPIIFALWLRKNLPEAEDWKEKHAGKA-PVRTMVDILYRGEHRIiniLLTLA------------------AA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 254 AELWSpAYRRRTLTVWGLWFFALL---GFYGLTSWLSALLQQSGFAVTQSVYYTVLISLAgIPGFLcAAWLVESWGRKPS 330
Cdd:PRK03893 235 AALWF-CFAGNLQNAAIVAVLGLLcaaIFISFMVQSSGKRWPTGVMLMVVVLFAFLYSWP-IQALL-PTYLKTDLGYDPH 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 331 CV---LMLLGGGAM-----------------AYAYGQTA-------VF---GGSLALLIGFGLAMQFFLFGMWAVLYTYT 380
Cdd:PRK03893 312 TVanvLFFSGFGAAvgccvggflgdwlgtrkAYVCSLLIsqlliipVFaigGANVWVLGLLLFFQQMLGQGISGLLPKLI 391
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15598663 381 PELYPTSARATGSGFASAVGRIGSLLGPLVTGLVLPLTGQGGvfTLGALCFGVAALVVWAFGIETRGR 448
Cdd:PRK03893 392 GGYFDTEQRAAGLGFTYNVGALGGALAPILGALIAQRLDLGT--ALASLSFSLTFVVILLIGLDMPSR 457
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
27-439 |
3.49e-25 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 106.09 E-value: 3.49e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 27 IIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCS 106
Cdd:cd17324 3 ALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 107 TAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFLVLA-L 185
Cdd:cd17324 83 LAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAvL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 186 PAVFVLAIRFLIPesprwleqagrreqadrvlrdiearvmrslgltelppplRQPQRERSRPGFFSAFAELWSpayRRRT 265
Cdd:cd17324 163 ALLAALLLWRLLP---------------------------------------SLPPKKPGSLGLLSSLLLLLR---NPRL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 266 LTVWGLWFFALLGFYGLTSWLSALLQQSGFAVTQSVyyTVLISLAGIPGFL---CAAWLVESWGRKPSCVLMLLGGGAMA 342
Cdd:cd17324 201 RLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAI--IGLLLLFGVAGVVgspLAGRLADRGGRRALLIALLLLAAALL 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 343 YAYGQTAVFGGSLALLIGFGLAMQFFLFGMWAVLYTYTPElyptsARATGSGFASAVGRIGSLLGPLVTGLVLPLTGQGG 422
Cdd:cd17324 279 LLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPE-----ARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAG 353
|
410
....*....|....*..
gi 15598663 423 VFTLGALCFGVAALVVW 439
Cdd:cd17324 354 VGWVGAALLLLALLLAL 370
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
21-441 |
5.02e-25 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 106.09 E-value: 5.02e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 21 HRLVFVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGL 100
Cdd:COG0738 6 YRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 101 ASYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRgKYIALMDGFWPLGFVAAGCLSYFLLPL---TGWR 177
Cdd:COG0738 86 GLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAA-SRLNLLHAFFSLGALLGPLLGGLLILLglsLSWH 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 178 SIFLVLALP--AVFVLAIRFLIPESprwleqagrreqadrvlrdiearvmrslgltelppplrqPQRERSRPGFFSAFAE 255
Cdd:COG0738 165 LPYLILAVLllLLALLFLRSKLPEI---------------------------------------EEEEEEAAGSAASLKS 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 256 LWSpayRRRTLTVWGLWFFALLGFYGLTSWLSALLQQS-GFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKP----S 330
Cdd:COG0738 206 LLK---NPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVlGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRllrlS 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 331 CVLMLLGGGAMAYAYGQTAVFGGslALLIGFGLAMqfflfgMWAVLYTYTPELYPTSARATGSGFaSAVGRIGSLLGPLV 410
Cdd:COG0738 283 ALLAAVGLLLALLAPGPWLALIG--LALVGLGLSL------MFPTIFSLALDGLGKRTAAAVSAV-LIMGIVGGAIGPPL 353
|
410 420 430
....*....|....*....|....*....|.
gi 15598663 411 TGLVLPLTGQGGVFTLGALCFGVAALVVWAF 441
Cdd:COG0738 354 IGFLADAFGLRAAFLVPLVCYLLILLLALAL 384
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
26-437 |
6.70e-25 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 105.82 E-value: 6.70e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 26 VIIA-LAFFFDSMDLAMMTFLLGSIKAEFG-----LDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWG 99
Cdd:cd17364 1 IIIAgMGFFTDAYDLFSISLVTKILGRLYYggkgsLPSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 100 LASYLCSTA------GDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLpl 173
Cdd:cd17364 81 IGTILSALSpgstplGVMGWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMQGFGILAGAIVTLILS-- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 174 tgwrsiflvlalpavfvlairfLIPESPrwlEQAGRREQADRVLRDIearvmrsLGLTELPPPLRQPqrersrpgffsaf 253
Cdd:cd17364 159 ----------------------AIFEHP---LPAGTYHHADLVWRIV-------LGLGAIPALSVLY------------- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 254 aelwspaYRRRTLTVWGLWFFALLGFYGLTSWLSALLQQSGFAVTQSVYY---------TVLISLAGIPGFLCAAWLVES 324
Cdd:cd17364 194 -------FRKHLLGTAGTWFLLDIAFYGQNLFQSTIISAIGFSKTMNAYQelfniavgqLIIALAGTVPGYWFTVFLIDR 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 325 WGRKP----SCVLMLLGGGAMAYAYGQTAvfGGSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVG 400
Cdd:cd17364 267 IGRKKiqmmGFFGMTIFLLILAGPYDHWK--ISTIGFFVLYGLTFFFSNFGPNTTTFIVPAEVFPARVRSTCHGISAASG 344
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 15598663 401 RIGSLLGplvTGLVLPLTGQGGV----FTLGALCFGVAALV 437
Cdd:cd17364 345 KIGAIVG---SFLFLSLTQNIGVrnvlIILAGVALLGIILT 382
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
16-442 |
6.74e-25 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 105.73 E-value: 6.74e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 16 PLSPYHRLVFVIIALAFFFDSMDLAMMTF--LLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQA 93
Cdd:COG2807 9 RRSRRAGRWLLLLAIVLVALNLRPAITSVgpLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 94 SIVLWGLASYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPAsRRGKYIALMDGFWPLGFVAAGCLSYFLLPL 173
Cdd:COG2807 89 ALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 174 TGWRSIFLVLALPAVFVLAIrflipesprWLeqagrreqadrvlrdiearvmrslgltelpPPLRQPQRERSRPGFFSAF 253
Cdd:COG2807 168 LGWRGALAVWALLALLALLL---------WL------------------------------PLLRRRPAAAAAAPAAASL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 254 AELWSpayRRRTLTVWGLWFFALLGFYGLTSWLSALLQQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKP---- 329
Cdd:COG2807 209 RSLWR---SPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRplll 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 330 -SCVLMLLGGGAMAYAYGQTAVFGgslALLIGFGLAMQFFLFGMWAVLYTYTPELYptsarATGSGFASAVGRIGSLLGP 408
Cdd:COG2807 286 lLGLLGLAGLLGLLLAPGSLPWLW---AVLLGLGQGGLFPLALTLIGLRARTPAEA-----AALSGMAQSVGYLLAALGP 357
|
410 420 430
....*....|....*....|....*....|....*
gi 15598663 409 LVTGLVLPLTGQ-GGVFTLGALCFGVAALVVWAFG 442
Cdd:COG2807 358 LLVGALHDATGSwTAALLLLAALAVLMLVAGLLAG 392
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
52-441 |
3.14e-24 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 103.42 E-value: 3.14e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 52 EFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVLLGIGMGMEFPI 131
Cdd:cd17315 28 GFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 132 AQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLL--PLTGWRSIFLVLALPAVFVLAIRFLIPESprwleqagr 209
Cdd:cd17315 108 VPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSlsPPGWWRLMFALAAVPALLQLLLMFFLPES--------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 210 reqadrvlrdiearvmrslgltelppplrqpqrersrpgffsafaelwspayrRRTLTVWGLWFF-ALLGFYGLTSWLSA 288
Cdd:cd17315 179 -----------------------------------------------------RALLVGVGLQLLqQLTGINAVMYYAPT 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 289 LLQQSGfAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKP----SCVLMLLGGGAMAYAYGQTAVFGGSLALLIGFGLA 364
Cdd:cd17315 206 IFKSAG-GGTASILASIIVGVVNLLATLVAIRLVDKVGRRPllliGFAGMAASLLLLAIAFLLPALAKAAGWLALLGILL 284
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15598663 365 MQ-FFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLVLPLTGQGGVFTLgalcFGVAALVVWAF 441
Cdd:cd17315 285 YIaAFAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWIFNFIVGLTFLIMVSTIGLAGVFIF----FAAVCLLALVF 358
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
43-453 |
1.07e-23 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 103.23 E-value: 1.07e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 43 TFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLW------------GLASYLCSTAGD 110
Cdd:PRK10077 40 TVFVAPQNLSESAANSLLGFCVASALIGCIIGGALGGYCSNRFGRRDSLKIAAVLFfisalgsawpefGFTSIGPDNTGY 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 111 LDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFL--------LPLTGWRSIFLV 182
Cdd:PRK10077 120 VPEFVIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQLVVYFVNYFIarsgdaswLNTDGWRYMFAS 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 183 LALPAVFVLAIRFLIPESPRWLEQAGRREQADRVLRDIEARVMRSLGLTELPPPLRQPQRERSRPGFFSAFaelwspayr 262
Cdd:PRK10077 200 EAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILRKIMGNTLATQALQEIKHSLDHGRKTGGKLLMFGVG--------- 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 263 rrtLTVWGLWFFALLGFYGLTSWL---SALLQQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPscvLMLLGGG 339
Cdd:PRK10077 271 ---VIVIGVMLSVFQQFVGINVVLyyaPEIFKTLGASTDIALLQTIIVGVINLTFTVLAIMTVDKFGRKP---LQIIGAL 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 340 AMA---YAYGQTAVFGGS-LALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIG----SLLGPLVT 411
Cdd:PRK10077 345 GMAigmFSLGTAFYTQAPgIVALLSMLFYVAAFAMSWGPVCWVLLSEIFPNAIRGKALAIAVAAQWIAnyfvSWTFPMMD 424
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 15598663 412 GLVLPLTGQGGVFTLGAL-CFGV-AALVVWAFGIETRGRTLEEL 453
Cdd:PRK10077 425 KNSWLVAHFHNGFSYWIYgCMGVlAALFMWKFVPETKGKTLEEM 468
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
28-438 |
6.43e-23 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 99.81 E-value: 6.43e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 28 IALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCST 107
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 108 AGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLL--PLTGWRSIFLVLAL 185
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 186 PAVFVLAIRFLIPESPRWleqagrreqadrvlrdiearvmrslgltelppplrQPQRERSRPGFFSAFAELWSPAYRRRT 265
Cdd:cd06174 161 LALLAAILLLLVVPDPPE-----------------------------------SARAKNEEASSKSVLKLLKRVLKNPGL 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 266 LTVWGLWFFALLGFYGLTSWLSALLQQSG-FAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPSCVLMLLGGGAMAYA 344
Cdd:cd06174 206 WLLLLAIFLVNLAYYSFSTLLPLFLLDLGgLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLA 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 345 YgqtAVFGGSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLVLPLTGQGGVF 424
Cdd:cd06174 286 L---LLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGA 362
|
410
....*....|....
gi 15598663 425 TLGALCFGVAALVV 438
Cdd:cd06174 363 FLVLAVLLLLAAIL 376
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
46-437 |
1.69e-22 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 98.50 E-value: 1.69e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 46 LGSIKAEFG---LDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVLLG 122
Cdd:cd17360 20 LLYIKDDLGevvLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 123 IGMGMEFPIAQSLLSEMIPASRRGKYIALmDGFWPLG--FVAAGCLSYFLLPLTGWRSIFLVLALPAVFVLAIRFLIPES 200
Cdd:cd17360 100 LGVGIASMTVPLYIAEAAPPRIRGRLVTI-NVLFITGgqFVAYVINGAFSYLPGGWRWMLGLAAVPAVLQFIGLLFLPES 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 201 PRWleqagrreqadrvlrdiearvmrslgltelppplrqpqrersrpgffsafaelwsPAYRRRTLTVWGL-WFFALLGF 279
Cdd:cd17360 179 PRW-------------------------------------------------------PSTRRALIVGCGLqAFQQFSGI 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 280 YGLTSWLSALLQQSGFAVTQ-SVYYTVLISLAGIPGFLCAAWLVESWGRKpscVLMLLGGGAMAYAYGQTAVFggslALL 358
Cdd:cd17360 204 NTVMYYSATILQMAGFKDNQnAIWLSLIVAGTNFIFTIVGMYLIDKFGRR---KLLLISLFGVIVALVVLAVW----LAL 276
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15598663 359 IGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLVLPLTGQGGVFTLGAlCFGVAALV 437
Cdd:cd17360 277 VGLILYLAFFAPGMGPVPWTVNSEIYPLWARGTGGGCAAAVNWVFNLLVSQTFLTLTQAIGPYGTFLLFA-GLAVLGLI 354
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
30-205 |
4.77e-21 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 95.00 E-value: 4.77e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 30 LAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAG 109
Cdd:PRK12307 25 LGYVFDGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLAS 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 110 DLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFLVLALPAVF 189
Cdd:PRK12307 105 GVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFVGLLPVLL 184
|
170
....*....|....*.
gi 15598663 190 VLAIRFLIPESPRWLE 205
Cdd:PRK12307 185 VIYIRARAPESKEWEE 200
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
54-453 |
1.23e-19 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 90.39 E-value: 1.23e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 54 GLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYL-CSTAGDLDSLTFYRVLLGIGMGMEFPIA 132
Cdd:cd17356 41 YPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIqVAAIGKWYQLIVGRIIAGLGVGFASVLV 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 133 QSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSY---FLLPLTGWRSIFLVLALPAVFVLAIRFLIPESPRWLeqagr 209
Cdd:cd17356 121 PVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYgthKLDGSAQWRIPLGLQIVWGLLLLIGMFFLPESPRWL----- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 210 reqadrvlrdiearvmrslgltelppplrqpqrersrpgffsafaelwspayrRRTLTVWGLWFFALLG------FYGLT 283
Cdd:cd17356 196 -----------------------------------------------------YRTILGIMLQLFQQLTginyffYYGTT 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 284 SWLSALLQQSGFAVTQSVYYTVLISLAgipgfLCAAWLVESWGRKPscvLMLLGGGAMA---YAYGQTAVFGGSLALLI- 359
Cdd:cd17356 223 IFQSTGLTGSSPLLTSIILYIVNFVST-----IPGLFFVDKFGRRT---CLLIGAAGMSiclFIYAAVGVRYLIPNPQSg 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 360 ------GFGLAMQFFLFGMW------AVLYTYTPELYPTSARATGSGFASAVGRIGSLlgpLVTGLVLPLTGQ--GGVFT 425
Cdd:cd17356 295 tsnksaGNGMIVFICLFIFSfattwgPIAWVYVAEVFPLRVRSKGMALATAFNWLWNF---LISFFTPFIIGSigFKYYY 371
|
410 420
....*....|....*....|....*...
gi 15598663 426 LGALCFGVAALVVWAFGIETRGRTLEEL 453
Cdd:cd17356 372 IFAGCNLLAFIVVFFFVPETKGLTLEEI 399
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
25-441 |
9.47e-19 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 87.63 E-value: 9.47e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 25 FVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYL 104
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 105 CSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLpLTGWRSIFLVLA 184
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 185 LPAVFVLAIRFLIPESPRWLEQAGRREQADRVLRDIEARVMRSLGLTELPPPLrqpqrersrpGFFSAFAELWSPAYRRR 264
Cdd:cd17474 160 ALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFF----------LYFAFLTYLPFLLELLY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 265 TLTVW--GLWFFALLGFYGLTSWLSALLQQSGFAVTQSVYYtvlislagipgflcaawlveswgrkpSCVLMLLGGGAMA 342
Cdd:cd17474 230 GISPIiiGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVI--------------------------GLLLYALSLLLLG 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 343 YAYGQTAVFGGSLALLIGFGLAMqfflfgmwAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLVLPLTGQGG 422
Cdd:cd17474 284 FVPSLALLLIAIVLFGLGLGLNL--------PLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSA 355
|
410
....*....|....*....
gi 15598663 423 VFTLGALCFGVAALVVWAF 441
Cdd:cd17474 356 PFLVGAAIALAAAVLLALL 374
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
25-414 |
1.55e-18 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 87.29 E-value: 1.55e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 25 FVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYL 104
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 105 CSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLG-FVAAGCLSYFLLPLTGWRSIFLVL 183
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGsGLGYVVGGLVAQATGGWRWAFRVT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 184 ALP-AVFVLAIRFLIPESPRwleqagrreqadrvlRDIEARVMRSLGLTELPPPLRQPQRERSrpgFFSAFAELWSPAYR 262
Cdd:cd17328 161 GVLgVLLAILLLLFVREPPR---------------GAAEGGVMAKSTATSFLADLKALAKNPS---FILSTLGFTAVSFV 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 263 RRTLTVWGLWFFallgfygltswLSALLQQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPSCVLMLLGGGAMA 342
Cdd:cd17328 223 TGALAFWAPTFF-----------LRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLL 291
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15598663 343 YA----YGQTAVFGGSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGR-IGSLLGPLVTGLV 414
Cdd:cd17328 292 AAapflFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHlLGDAGSPYLIGLI 368
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
28-192 |
7.32e-18 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 84.92 E-value: 7.32e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 28 IALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCST 107
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 108 AGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFLVLALPA 187
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160
|
....*
gi 15598663 188 VFVLA 192
Cdd:cd17321 161 LVALL 165
|
|
| MFS_SVOPL |
cd17442 |
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ... |
23-445 |
1.57e-17 |
|
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341000 [Multi-domain] Cd Length: 375 Bit Score: 83.70 E-value: 1.57e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 23 LVFVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLAS 102
Cdd:cd17442 1 LLFLIMGSTGVAEAMEIMLLAVVSPEIRCEWHLEDWQVALVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 103 YLCSTAGDLDSLTFYRVLLGIGMGMEfpiAQSLL--SEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIF 180
Cdd:cd17442 81 LLTSFAPSYIWFVFLRCMVGCGVSGH---SQGLIikTEFLPTKYRGYMLPLSQIFWLAGSLLIIGLASVVIPTLGWRWLI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 181 LVLALPAVFVLAIRFLIPesprwleqagrreqadrvlrdiearvmrslgltelppplrqpqrersrpgffsafaelwspa 260
Cdd:cd17442 158 RFASIPGIILIVVFKFIP-------------------------------------------------------------- 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 261 yrRRTLTVWGLWFFALLGFYGLTSWLSALLQQSGFAVTQ------------------------SVYYTVLISLAGIPGFL 316
Cdd:cd17442 176 --RTTLQIWVIWLGISFAYYGVILASSELLERNLLCGSDpsdeeagikhiesespcychmfnpSDYQTMIISTLGEIALN 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 317 -CAAWLVESWGRKPSCVLMLlgggamayayGQTAVF------GGSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSAR 389
Cdd:cd17442 254 pLNILGINFLGRRLSLVITM----------GLTAIFflllniCTSSAGLTIFLFMLRALVSANFNTVYIYTAEVYPTTMR 323
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 15598663 390 ATGSGFASAVGRIGSLLGPLVTGLVLPLTgqggvfTLGALCFGVAALVVWAFGIET 445
Cdd:cd17442 324 ALGMGTSGSLCRIGAMVAPFISQVLMSAS------VLGALCLFSSVCIVCAISAFT 373
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
53-419 |
2.08e-17 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 83.73 E-value: 2.08e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 53 FGLDSAQAGLLASSSFFGMV-----IGAALSGMLADRFGRKPVFQASIVLWGLASYLC------STAGDLD--SLTFYRV 119
Cdd:cd17369 34 FPAVDPAAGTLAAFATFGVGflarpLGGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIgllptyAQIGILApiLLVLLRL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 120 LLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLT--------GWRSIFLVLALPAVFVL 191
Cdd:cd17369 114 LQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGVFLLLSALLsdeaflswGWRIPFLLSAVLVAVGL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 192 AIRFLIPESPRWLEQagrREQADRVLRDIEARVMRslgltelppplrqpqrersrpgffsafaelwspaYRRRTLTVWGL 271
Cdd:cd17369 194 YIRLRLEETPVFRRA---KEAGQVVRAPLVEVLRR----------------------------------HWRALLLAIGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 272 WFFALLGFYGLTSW-LSALLQQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPSCVLMLLGGGAMAYAYGQTAV 350
Cdd:cd17369 237 RLAENVLFYLFTTFaLSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLD 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 351 FGGSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRI-GSLLGPLVTGLVLPLTG 419
Cdd:cd17369 317 TGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAIlGGGFAPLIATALVAATG 386
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
28-193 |
2.82e-17 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 83.01 E-value: 2.82e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 28 IALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCST 107
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 108 AGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFLVLALPA 187
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160
|
....*.
gi 15598663 188 VFVLAI 193
Cdd:cd17503 161 ILALLL 166
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
26-442 |
4.27e-17 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 82.62 E-value: 4.27e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 26 VIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSA-QAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYL 104
Cdd:cd17473 2 ITLLLASTLTVMAGAAIAPALPAIAQHFVPNSElLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 105 CSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLtGWRSIFLVLA 184
Cdd:cd17473 82 GLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFLVYL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 185 LPAVFVLAIRFLIPESPRwleqagrreqadrvlRDIEARVMRSLGLTELPPplrqpqrersrpgffsafaelwspayrRR 264
Cdd:cd17473 161 LALPVLILVLLFLPEPAR---------------KSKSAASPGAATAAALPW---------------------------KR 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 265 TLTVWGLWFFALLGFYGLTSWLSALLQQSGFAVTQSV-YYTVLISLAGIPGFLCAAWLVESWGRKP----SCVLMLLGGG 339
Cdd:cd17473 199 VLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIgLALAIASLAGAIGALLFGRLKRRLGKRRllaiGFALMALGFL 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 340 AMAYAYGQTAVFGGSLALLIGFGLAMqfflfgmwAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTG-LVLPLT 418
Cdd:cd17473 279 LLALASGLWVVLLGAILAGLGFGLLL--------PTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGpLVNLTG 350
|
410 420
....*....|....*....|....
gi 15598663 419 GQGGVFTLGALCFGVAALVVWAFG 442
Cdd:cd17473 351 GLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
29-442 |
7.60e-17 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 81.45 E-value: 7.60e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 29 ALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTA 108
Cdd:cd17380 5 FLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 109 GD--LDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFLVLALp 186
Cdd:cd17380 85 AYssLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGL- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 187 avfvlairflipesprwleqagrreqadrvlrdiearvmrsLGLtelppplrqpqrersrpgffsafaeLWSPAYRRRTL 266
Cdd:cd17380 164 -----------------------------------------LGL-------------------------LWALVWLIYLP 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 267 TVWGLWF--FAL-LGFYGLTSWLSALLQQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESW---------GRKPSCVLM 334
Cdd:cd17380 178 PVWAIIVahFCMnWGFYILLSWLPTYFHEVLVPLAKGWVFNVVPWLVMFPSSNVAGWLADHLisrgwtvtsVRKLMQSIG 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 335 LLGGGAMAYAYGQTAVFGGSLALLigfGLAMQFFLFGmWAVLYTYTPELYPTSARATgSGFASAVGRIGSLLGPLVTGLV 414
Cdd:cd17380 258 FLGPALFLLLLSHTDSFSLALLCM---SVALGLSAFS-SSGVLVNHQDIAPNYAGIV-FGISNTAGTIPGIVGVYLTGYI 332
|
410 420
....*....|....*....|....*....
gi 15598663 415 LPLTGQ-GGVFTLGALCFGVAALVVWAFG 442
Cdd:cd17380 333 LEATGSwSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
38-453 |
1.57e-16 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 80.91 E-value: 1.57e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 38 DLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFY 117
Cdd:cd17437 12 DIGVMSGAVIFIKEDLKISDVQEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 118 RVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLT---GWRSIFLVLALPAVFVLAIR 194
Cdd:cd17437 92 RFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGYVSNYAFSGLPlhvGWRLMLGVGAVPSLFLAIGV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 195 FLIPESPRwleqagrreqadrvlrdiearvmrslgltelppplrqpqrersrpgffsafaelWSPAYRRRTLTVWGLWFF 274
Cdd:cd17437 172 LAMPESPR------------------------------------------------------WTPAVRRMLIAALGIHFF 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 275 ALLGFYGLTSWLS-ALLQQSGFAV-TQSVYYTVLISLAGIPGFLCAAWLVESWGRKP----SCVLMLLGGGAMAYAYGQT 348
Cdd:cd17437 198 QQASGIDAVVLYSpRIFKKAGIKSkDKLLLATVAVGVTKTLFILVATFLLDKVGRRPllltSTGGMTLSLTALATSLTFI 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 349 AVFGGSLALLIGFGLA-----MQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSllgPLVTGLVLPLTGQ--- 420
Cdd:cd17437 278 DRNGGGLTWALVLAITavcsfVAFFSIGAGPITWVYSSEIFPLRLRAQGASLGVVVNRLMS---GTVSMTFLSMSKAitt 354
|
410 420 430
....*....|....*....|....*....|...
gi 15598663 421 GGVFTLGALCFGVAALVVWAFGIETRGRTLEEL 453
Cdd:cd17437 355 GGTFFLFAGVAAAAWVFFYFFLPETKGKSLEEI 387
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
53-453 |
1.74e-16 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 80.86 E-value: 1.74e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 53 FGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVLLGIGMGMEFPIA 132
Cdd:cd17362 34 YNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 133 QSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLT-GWRSIFLVLALPAVFVLAIRFLIPESPRwleqagrre 211
Cdd:cd17362 114 PVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVVgGWRYMYGLAAPPALLLGIGMWFLPPSPR--------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 212 qadrvlrdiearvmrslgltelppplrqpqrersrpgffsafaelWSPAYRRRTLTVWGLWFFA-LLGFYGLTSWLSALL 290
Cdd:cd17362 185 ---------------------------------------------WQGNYRKPLIIGLGLVLFQqITGQPSVLYYAATIF 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 291 QQSGF-AVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPscvLMLLGGGAMA---------YAYGQTAVFGGSLALLIG 360
Cdd:cd17362 220 KSAGFsAASDATLVSVGLGVFKLLMTIVAVLLVDKLGRRP---LLLGGVSGMVvslfllaayNLFVQMGPAGLAWLSLVA 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 361 FGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLVLPLTGQGGVFTLGALCFGVAALVVWA 440
Cdd:cd17362 297 LLLYVGAYQISFGPISWLMVSEIFPLRVRGRAIALAVLVNFGSNALVSLAFLPLQELIGLPGTFLGFGVIGVLALLFIYF 376
|
410
....*....|...
gi 15598663 441 FGIETRGRTLEEL 453
Cdd:cd17362 377 TVPETKGLSLEEI 389
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
27-424 |
1.93e-16 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 80.50 E-value: 1.93e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 27 IIALAFFFDSMDLAmmtFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCS 106
Cdd:TIGR00881 2 IGYAAYYLVRKNFA---LAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 107 TAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKyialMDGFWPLG-FVAAGCLSYFLLP----LTGWRSIFL 181
Cdd:TIGR00881 79 FSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGT----WVSFWNCShNVGGGLLPPLVLFgiaeLYSWHWVFI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 182 VLALPAVFVLAIRFLIpesprwleqaGRREQADRVLRDIEarvmrslgltELPPPLRQPQRERSRPGFFSAFAELWspaY 261
Cdd:TIGR00881 155 VPGIIAIIVSLICFLL----------LRDSPQSCGLPPAE----------EMPNEEPDGDAEKKEEELTKKQIFLQ---Y 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 262 RRRTLTVWGLWFFALLGF---YGLTSWLSA-LLQQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVES-WGRKPSCVLMLL 336
Cdd:TIGR00881 212 VLLNKVLWYISLGYVFVYvvrTGILDWSPLyLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKlFNGRRGPLAVFF 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 337 GGGAMAYAYGQTAVFGGSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLVLP 416
Cdd:TIGR00881 292 MALIIVSLLVYWLNPAANPLMDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLAD 371
|
....*...
gi 15598663 417 LTGQGGVF 424
Cdd:TIGR00881 372 GFGWAGAF 379
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
28-442 |
4.65e-16 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 79.18 E-value: 4.65e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 28 IALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCST 107
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 108 AGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFLVLALPA 187
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 188 VFVLAIRFLIPEsprwleqagrreqadrvlrdiearvmrslgltelpPPLRQPQRERSRPGFFSAFaelwspaYRRRTLT 267
Cdd:cd17489 161 LLALLLVFLVKD-----------------------------------PPPVAAEEAEAGTRAFRRL-------VEKKVLP 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 268 VWGLWFFALLGFYGLTSWLSALLQQSGFAVTqSVYYTVLISLAGIPGFLCaAWLVESWGRKPSCV--LMLLGGGAMAYAY 345
Cdd:cd17489 199 PALILFLASIAYGAISTFLPLYAAERGISNA-GLFFTVYAIALLLSRPFS-GKLSDRKGPKTVIIpgLLLLALGLLLLSF 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 346 GQTAVFGGSLALLIGFGLAMQFFLFGMWAVlytytpELYPTSARATGSGFASAVGRIGSLLGPLVTGLVLPLTGQGGVFT 425
Cdd:cd17489 277 AGSPWMLLLAAVLYGLGFGLLFPALQALAV------DLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFL 350
|
410
....*....|....*..
gi 15598663 426 LGALCFGVAALVVWAFG 442
Cdd:cd17489 351 LAAVVVLLALVLYIFLL 367
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
63-410 |
2.27e-15 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 76.95 E-value: 2.27e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 63 LASSSFF-GMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIP 141
Cdd:cd17374 39 VAQSIFMaGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTT 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 142 ASRRGKYIALMDGFWPLGFVAAGCLSYFLlplTGWRSIFLVLalpavfvlairflipesprwleqagrreqadrvlrdie 221
Cdd:cd17374 119 PRHRALAITLTSCFFSIGQMLLAGLAYAI---RDWRLLQLVV-------------------------------------- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 222 arvmrslgltelppplrqpqrerSRPGFFSAFAELWSPayrRRTLTVWGLWFFALLGFYGLTswlsalLQQSGFAVtqSV 301
Cdd:cd17374 158 -----------------------SVPFFLFFLYSWWLP---KRTLILSFVWFANSFSYYGLS------LDLQHLGL--NV 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 302 YYT-VLISLAGIPGFLCAAWLVESWGRKPS-CVLMLLGGGAMAYAYGQTAVFGG---SLALLIGFGLAMQFflfgmwAVL 376
Cdd:cd17374 204 FLLqFLFGAVEVPARCLALFLLNHMGRRISqAVLLLLAGLCILANIFVPQEMQTlrtVLAVLGKGSSAAAF------TIS 277
|
330 340 350
....*....|....*....|....*....|....
gi 15598663 377 YTYTPELYPTSARATGSGFASAVGRIGSLLGPLV 410
Cdd:cd17374 278 YVYTAELFPTVLRQTGMGLNSMFARIGGILAPLI 311
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
25-415 |
2.92e-15 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 76.85 E-value: 2.92e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 25 FVIIALAFffdSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYL 104
Cdd:cd17504 1 LALAALAV---MLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 105 CSTAGDLDSLTFYRVLLGIGMGMeFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFLVLA 184
Cdd:cd17504 78 AAFAPNLPVLIAGRALQGIGGAV-FPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 185 LPAVFVLAIRFLIPesprwleqagrreqadrvlrdieARVMRslgltelppplrqpqrersrpgffsafaelwspayRRR 264
Cdd:cd17504 157 PVAVLLAALVPLID-----------------------LRLLR-----------------------------------RRN 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 265 TLTVWGLWFFALLGFYGLTSWLSALLQQ-----SGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPscvLMLLGGG 339
Cdd:cd17504 179 VLLANITALLAGFGMFMVFQLLPQLLQLptptgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRR---VLLIGLV 255
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15598663 340 AMAYAYGQTAVFGGSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLVL 415
Cdd:cd17504 256 ISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAIL 331
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
26-443 |
4.34e-15 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 76.46 E-value: 4.34e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 26 VIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLC 105
Cdd:cd17320 2 LLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 106 STAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFLVLAL 185
Cdd:cd17320 82 ALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 186 PAVFVLAIRFLIpesprwleqagrreqadrvlrdiearvmrslglteLPPPLRQPQRERSRPGFFSAFAELW-SPAYRRR 264
Cdd:cd17320 162 LGLLLLLLVLLF-----------------------------------LPETLPEEKRKPLLSSLLRAYKRVLkNRRFLGY 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 265 TLTVwGLWFFALLGFYGLTSWLsaLLQQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPS--CVLMLLGGGAMA 342
Cdd:cd17320 207 ALAL-GLSFAGLFAYLAAAPFI--YIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLlrLGLLLLLAAALV 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 343 YAYGQTAVFGGSLALLIGFGLAMqfFLFGMwavlytytpeLYPTSARATGSGFASAVGRIGSLLGPL---VTGLVLPLTG 419
Cdd:cd17320 284 LLLAALLGGLSLWPLVAPLFLIF--FGFGL----------IFPNATSLALEPFPHVAGTASALLGFLqflIGALAGALVG 351
|
410 420
....*....|....*....|....*..
gi 15598663 420 Q---GGVFTLGALCFGVAALVVWAFGI 443
Cdd:cd17320 352 LlpnGTALPMGLLILVLGLLALLLLIL 378
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
23-197 |
2.53e-14 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 74.72 E-value: 2.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 23 LVFVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLAS 102
Cdd:TIGR00711 2 LLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 103 YLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFLV 182
Cdd:TIGR00711 82 LLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLI 161
|
170
....*....|....*
gi 15598663 183 LALPAVFVLAIRFLI 197
Cdd:TIGR00711 162 NVPIGIIVVVVAFFI 176
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
28-182 |
3.17e-14 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 73.37 E-value: 3.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 28 IALAFFFDSMDLAMMTFLLGSIKAEFGlDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCST 107
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15598663 108 AGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFLV 182
Cdd:cd17502 80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYI 154
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
67-399 |
1.00e-13 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 72.71 E-value: 1.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 67 SFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDS--------LTFYRVLLGIGMGMEFPIAQSLLSE 138
Cdd:cd17367 49 GFLMRPIGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYATigiwapiiLLLARLLQGLSVGGEYGTSATYLSE 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 139 MIPASRRG-----KYIALMDGFWpLGFVAAGCLSYFLLPLT----GWRSIFLVLALPAVFVLAIRFLIPESPRWLEQAGR 209
Cdd:cd17367 129 VAPPGRRGfyssfQYVTLIGGQL-LALGVLLVLQHTLGEDQmaawGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAES 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 210 REQADRVLRdiearvmrslgltelppplrqpqrersrpgffsafaELWSpaYRRRTLTVWGLWFFALLGFYGLTSWLSAL 289
Cdd:cd17367 208 NEASAGTLR------------------------------------ELRR--HPRELLLVVGLTAGGTLAFYTWTTYLQKF 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 290 LQQS-GFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPscVLMLLGGGAMAYAYG-------QTAVFGGSLALLIGF 361
Cdd:cd17367 250 LVNTaGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRP--LLLFFGIGGTLATVPllsaldhTDSPYTAFALVLVGL 327
|
330 340 350
....*....|....*....|....*....|....*...
gi 15598663 362 glamqFFLFGMWAVLYTYTPELYPTSARATGSGFASAV 399
Cdd:cd17367 328 -----VFLSGYTSINAVVKAELFPTHVRALGVGLPYAL 360
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
62-201 |
1.10e-13 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 72.28 E-value: 1.10e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 62 LLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIP 141
Cdd:cd17361 55 LFTSSLYLAGLVASLLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAP 134
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15598663 142 ASRRGKYIALMDGFWPLGFVAAGCLSYFL--LPLTGWRSIFLVLALPAVFVLAIRFLIPESP 201
Cdd:cd17361 135 AKLRGALNIGFQLAITIGILIANLINYGTskIKPNGWRLSLGLAAVPALILLLGSLFLPETP 196
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
21-439 |
3.42e-13 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 70.77 E-value: 3.42e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 21 HRLVFVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGL 100
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 101 ASYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIF 180
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 181 LVLA-LPAVFVLAIRFLIPESPRwleqagrreqadrvlrdiearvmrslGLTELppplrqpqrersrpGFFSAFAELwsp 259
Cdd:cd17312 161 LVPGiVGLVVAIILFFFLRDSPP--------------------------YVWVL--------------SLAYAFVYI--- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 260 ayRRRTLTVWGLWFfallgfygltswlsaLLQQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPSCVLMLLGGG 339
Cdd:cd17312 198 --VRYACLDWGPLY---------------LYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYML 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 340 AMAYAYGQTAVFGGSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTS-ARATGSGFASAVGRIGSLLGPLVTGLVLPLT 418
Cdd:cd17312 261 LMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKeAAGTATGFVGLFGYLGASLAGLPLGYIIDHY 340
|
410 420
....*....|....*....|....
gi 15598663 419 GQGGVF---TLGALCFGVAALVVW 439
Cdd:cd17312 341 GWSTVFyflISAALLSVLLLLSLW 364
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
49-439 |
1.47e-12 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 68.80 E-value: 1.47e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 49 IKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVLLGIGMGME 128
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 129 FPIAQSLLSEMIPASRRGKYIALMDGFWPLGfvaaGCLSYFLLPLT----GWRSIFLVLALPAVF--VLAIRFLipespr 202
Cdd:cd17475 102 QPGGGRAIMRWFPPRERGLAMGIRQTGVPLG----GALAAALLPPLalhyGWRAAFVVAGLVSILaaVLFWLFY------ 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 203 wleqagrREqadrvlrdiearvmrslgltelpPPLRQPQRERSRPGFFSAFAELWSPAYRRRTLTVWGLWFFAllgFYGL 282
Cdd:cd17475 172 -------RE-----------------------PPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQ---FALL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 283 TSWLSALLQQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESW--GRKPSCVLMLLGGGAMAYAYGQTAVFGGSLALLIG 360
Cdd:cd17475 219 TFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVfgGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 361 FGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLVLPLTG--QGGVFTLgALCFGVAALVV 438
Cdd:cd17475 299 LLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHsyAPAWLAL-ALLLVLAALLL 377
|
.
gi 15598663 439 W 439
Cdd:cd17475 378 L 378
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
68-452 |
9.05e-12 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 66.87 E-value: 9.05e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 68 FFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCS---TAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASR 144
Cdd:cd17432 60 PLGGLFGSLLVGPLVIRLGRKGTLLLNNIFAIVAAILMGlskIAKSFEMIIVGRFLVGINAGISLNVVPMYLGESAPKNL 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 145 RGkyialMDGFWPLGFVAAGCLSYFLLPL-------TGWRSIFLVLALPAVFVLAIRFLIPESPRW-LEQAGRREQADRV 216
Cdd:cd17432 140 RG-----AVGLVPAIFITLGILLGQVLGLrellgneEGWPLLLALTGVPALLQLLTLPFFPESPRYlLIEKGDEEAARKA 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 217 LRdiearvmRSLGLTELPPPL---RQPQRERSRPGFFSAFAELWSPAYRRRTLTVWGL------------WFFAllgfyg 281
Cdd:cd17432 215 LQ-------RLRGKEDVDDEMeemLEEQRAEKGVGTVSVLELFRDRSVRWQLISIIVLmagqqlcginaiYFYA------ 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 282 ltswlSALLQQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPscvLMLLGGGAMAYAYgqtAVFGGSLAL---- 357
Cdd:cd17432 282 -----DSIFLEAGIPEDKIQYVTVGTGACEVLATITCVLVIERLGRRP---LLIGGFGLMAVWC---AVLTVALSLqntv 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 358 -------LIGFGLAMQFFLFGMWAVLYTYTPELYPTSARatgsgfASAVGRIGSL--LGPLVTGLVLPLTGQGgvftLGA 428
Cdd:cd17432 351 swmpylsIVCIFAYIASFGIGPAGVPFILTTEIFDQSSR------PAAFMVAGSLnwLSNFLVGLLFPFIQEG----LGA 420
|
410 420 430
....*....|....*....|....*....|.
gi 15598663 429 LCFGV-------AALVVWAFGIETRGRTLEE 452
Cdd:cd17432 421 YCFLVfavicllTAIYIFFVLPETKGKTFLE 451
|
|
| MFS_SLC22A4_5_OCTN1_2 |
cd17376 |
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ... |
44-408 |
1.32e-11 |
|
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340934 [Multi-domain] Cd Length: 342 Bit Score: 65.56 E-value: 1.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 44 FLLGSIKAEFGL--DSAQAGLLASSSFF-GMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVL 120
Cdd:cd17376 18 VYLSTIVTEWNLvcEDDWKVPLTTSLFFvGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQIFSPSWEMFTVLFVI 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 121 LGIGMGMEFPIAQSLLSEMIPASRRGKyialmdgFWPLGFVAAGCLSYFLLPLTG-----WRSIFLVLALPAVFVLAIRF 195
Cdd:cd17376 98 VGMGQISNYVVAFVLGTEILGKSVRIL-------FSTLGVCIFYAIGYMLLPLFAyfirdWRMLLLALTLPGVLCVPLWW 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 196 LIPesprwleqagrreqadrvlrdiearvmrslgltelppplrqpqrersrpgffsafaelwspayrRRTLTVWGLWFFA 275
Cdd:cd17376 171 FIP----------------------------------------------------------------ITTIMSLLLWMAI 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 276 LLGFYGLTSWLSALlqqSGFAVTQsvyyTVLISLAGIPGFLCAAWLVESWGRKPSCVLMLLGGGA----MAYAYGQTAVF 351
Cdd:cd17376 187 SVGYFGLSLNTPNL---HGDPYLN----CFLSAVIEVPAYIIAWLLLRSLPRRYSIAATLVLGGGvllfIQLVPTDLQVL 259
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 15598663 352 GGSLALLIGFGLAMQFflfgmwAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGP 408
Cdd:cd17376 260 ATALVMLGKFGITAAF------SMVYVYTAELYPTVVRNMGVGVCSTASRIGSIISP 310
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
50-180 |
1.60e-11 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 65.72 E-value: 1.60e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 50 KAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLC--STAGDLDSLTFYRVLLGIGMGM 127
Cdd:cd17318 48 APEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTplAARGGYGALIVLRILQGLAQGV 127
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 15598663 128 EFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIF 180
Cdd:cd17318 128 TFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIF 180
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
24-202 |
2.05e-11 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 65.28 E-value: 2.05e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 24 VFVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGR--KPVFQASIVLWGLA 101
Cdd:COG2271 182 FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALA 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 102 SYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFL 181
Cdd:COG2271 262 LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFL 341
|
170 180
....*....|....*....|..
gi 15598663 182 VLALPAVF-VLAIRFLIPESPR 202
Cdd:COG2271 342 LLAALALLaALLALLLLRETRK 363
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
40-438 |
2.34e-11 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 64.89 E-value: 2.34e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 40 AMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRV 119
Cdd:cd17477 13 GLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 120 LLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVaagcLSYFLLPLTGWRSIFLVLALPAVFVLAirfLIPE 199
Cdd:cd17477 93 VMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFA----LGPLLLALVGTAGALPFLIAAVLLLLA---LVPL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 200 SPRWLEQAGRREQADRVLRDIearvmrslgLTELPPPLrqpqrersRPGFFSAFAElwspayrrrtltvwgLWFFALLGF 279
Cdd:cd17477 166 LLTRRAAPEIEEAESISLRRL---------LRIAPLAL--------LGAFVAGFLE---------------GAFYSLLPL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 280 YGLtswlsallqQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPscVLMLLGGGAMAYAYGQTAVFGGSLALLI 359
Cdd:cd17477 214 YGL---------RLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRR--VLLGCALLGALAALLLPLVPGLPLALLV 282
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15598663 360 GFGLAmQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLVLPLTGQGGVFTLGALCFGVAALVV 438
Cdd:cd17477 283 LLFLW-GGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
25-192 |
2.61e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 65.31 E-value: 2.61e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 25 FVIIALAFFFDSMDLAMM-TFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASY 103
Cdd:COG2211 230 FLLLLLAYLLFFLALALVaALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLL 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 104 LCSTAGDLDSLTFY--RVLLGIGMGMEFPIAQSLLSEMIPAS-------RRGKYIALMDGFWPLGFVAAGCLSYFLLPLT 174
Cdd:COG2211 310 LLFFLGPGNLWLLLvlAALAGIGLGAILVLPWAMLADVVDYDewktgrrREGLYFGIFTFAIKLGQALAGALAGLLLALF 389
|
170 180 190
....*....|....*....|....*....|
gi 15598663 175 GWRS------------IFLVLALPAVFVLA 192
Cdd:COG2211 390 GYVAgaaqspsaltgiRLLFFLLPAVLLLL 419
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
46-197 |
2.73e-11 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 65.04 E-value: 2.73e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 46 LGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVLLGIGM 125
Cdd:PRK10473 26 LPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGA 105
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15598663 126 GMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFLVLALPAVFVLAIRFLI 197
Cdd:PRK10473 106 GCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSLFI 177
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
22-441 |
3.10e-11 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 64.56 E-value: 3.10e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 22 RLVFVIIALAFFFDSMDLAMMTFLLgsiKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLA 101
Cdd:cd17329 2 WVLLIGSFLNRLGFFMVWPFMAIYL---HQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 102 SYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLpLTGWRSIFL 181
Cdd:cd17329 79 FALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL-LYSFRLLFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 182 VLALPAVFVLAIRFlipesprwleqagrreqadrvlrdiearvmrsLGLTELPPPLRQPQRERSRPGFFSAFAelwspay 261
Cdd:cd17329 158 AAAVLFLLAALVLL--------------------------------FLLPETRPKRRAAEKTEILRGYKIVLR------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 262 RRRTLTVWGLWFFALLGFYGLTSWLSALLQQSGFAVTQSvyYTVLISLAGIPGFLCAAWLVESWGRKPSCVLMLLGGGAM 341
Cdd:cd17329 199 DRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESL--LGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLF 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 342 AYAYGQTAVFGGSLALLIgfglAMQFFLFG---MWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLVLPLT 418
Cdd:cd17329 277 AIGFAVLAFANTLAVLIL----AMIVLTLGemlVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLL 352
|
410 420
....*....|....*....|....
gi 15598663 419 GQGGVF-TLGALCFGVAALVVWAF 441
Cdd:cd17329 353 GPGLPWlILAALGLIAAALLLGLQ 376
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
5-163 |
6.38e-11 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 63.45 E-value: 6.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 5 PASAAERLERLPLSPYHRLVFVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADR 84
Cdd:COG2814 190 PAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADR 269
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15598663 85 FGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAA 163
Cdd:COG2814 270 FGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
61-200 |
8.15e-11 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 59.97 E-value: 8.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 61 GLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMI 140
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15598663 141 PASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFLVLALPAVFVLA-IRFLIPES 200
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFIlLAFLLPET 141
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
24-408 |
1.43e-10 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 62.65 E-value: 1.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 24 VFVIIALAFFFDSMDLAMMT--FLLGsIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLA 101
Cdd:cd17327 6 ILPLLCILYFLQYLDKSNISnaAVMG-MKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 102 SYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLL------PLTG 175
Cdd:cd17327 85 TLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFkilgvgGLAG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 176 WRSIFLVLALPAVFV-LAIRFLIPESPrwleqagrreQADRVLRDIEARVMRslgltelppplrqpQRERSRPGFFSAFA 254
Cdd:cd17327 165 WRWLFIIEGLITIIIgLVIFFWLPDNP----------SKAWFLTEEEKELAV--------------ERLRANQTGKGDQK 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 255 ELWSPAyrRRTLTVWGLWFFALLGF------YGLTSWLSALLQQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRK 328
Cdd:cd17327 221 FKWKQI--KEAFKDPRTWLLFLFFFcsqitnNGISNFLPLILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKR 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 329 P-----SCVLMLLGGGAMAYAygQTAVFGGSLALLIGFGLAMQFFLFGMWAVLYTytpelYPTSARATGSGFASAVGRIG 403
Cdd:cd17327 299 GlfaifACVLALVGSIILLAA--PNPPGAYFAAYILGGGSYAGFPILLSWISSNC-----AGYTKRATVLAIMLIFYNVG 371
|
....*
gi 15598663 404 SLLGP 408
Cdd:cd17327 372 NIVAP 376
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
26-196 |
4.93e-10 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 60.74 E-value: 4.93e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 26 VIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSsfFGMVIGA--ALSGMLADRFGRKPVFQASIVLWGLASY 103
Cdd:cd17476 1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAAS--YSLTVGTfiLIFGRLGDIYGHKKMFVIGSFWFAIWSL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 104 LCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMI-PASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFLV 182
Cdd:cd17476 79 IAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYpPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWF 158
|
170
....*....|....
gi 15598663 183 LALPAVFVLAIRFL 196
Cdd:cd17476 159 LAILAAIVAVAAIF 172
|
|
| MFS_SLC22A15 |
cd17377 |
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ... |
63-413 |
5.12e-10 |
|
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 60.95 E-value: 5.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 63 LASSSFF-GMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIP 141
Cdd:cd17377 43 LASSFFFaGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNGGMSLVAFVLLNECVG 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 142 ASRRGKYIALMDGFWPLGFVAAGCLSYFLLPltgWRSIFLVLALPAVFVLAIRFLIPEsprwleqagrreqadrvlrdie 221
Cdd:cd17377 123 KSYWALAGSLGGLFFAVGIAQYALLGYFIRS---WRTLAVVVNLQGTLVFLLSLFIPG---------------------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 222 arvmrslgltelppplrqpqrersrpgffsafaelwspayrrRTLTVWGLWFFALLGFYGLTswLSAllqqsgFAVTQSV 301
Cdd:cd17377 178 ------------------------------------------RTLILMYVWFVCSLVYYGLT--LNA------GDLGGNI 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 302 YYTVLIS-LAGIPGF-LCAAWLVESW-GRKPSCV-LMLLGGGAMAYAY-----GQTAVFGG----SLALLIGFGLAMQFf 368
Cdd:cd17377 208 YLNLALSgLVELPAYpLCIYLINQKWsGRRRTLAgFLFLGGIACLLVMfvpekKDSGVFAVvnstSLSLLGKLTISAAF- 286
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 15598663 369 lfgmwAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGL 413
Cdd:cd17377 287 -----NIVYIYTSELYPTVVRNAGLGVCSMFSRVGGIIAPFIPSL 326
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
26-196 |
5.39e-10 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 61.49 E-value: 5.39e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 26 VIIALAFFFDSMDLAMMTFLLGSIKAEFGlDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLC 105
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 106 STAGDLDSLTFYRVLLGIGMGMEFpIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLL--PLTGWRSIFLVL 183
Cdd:cd06179 80 GTAKSVNMLIGGQALIGIGAGTQG-LGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVeaNAAGWRWIFYIN 158
|
170
....*....|...
gi 15598663 184 ALPAVFVLAIRFL 196
Cdd:cd06179 159 AIFNALALILLFF 171
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
48-288 |
5.80e-10 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 60.70 E-value: 5.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 48 SIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVLLGIGMGM 127
Cdd:PRK11102 16 VIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 128 EFPIAQSLLSEMIPA---SRRGKYIALMDGFWPLgfvAAGCLSYFLLPLTGWRSIFLVLALPAVF-VLAIRFLIPESprw 203
Cdd:PRK11102 96 ASVVINALMRDMFPKeefSRMMSFVTLVMTIAPL---LAPIIGGWLLVWFSWHAIFWVLALAAILaAALVFFFIPET--- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 204 leqagrreqadrvlrdiearvmrslglteLPPPLRQPQRERSRpgfFSAFAELWspayrrRTLTVWGLWFFALLGFYGLT 283
Cdd:PRK11102 170 -----------------------------LPKERRQPFHLRTT---IRNFASLF------RHKRVLGYMLASGFSFAGMF 211
|
....*
gi 15598663 284 SWLSA 288
Cdd:PRK11102 212 SFLTA 216
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
27-198 |
6.01e-10 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 60.90 E-value: 6.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 27 IIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCS 106
Cdd:PRK10504 14 IVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 107 TAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPasrRGKYIALMDgFWPL----GFVAAGCLSYFLLPLTGWRSIFLV 182
Cdd:PRK10504 94 LSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVP---REQYMAAMT-FVTLpgqvGPLLGPALGGLLVEYASWHWIFLI 169
|
170
....*....|....*..
gi 15598663 183 -LALPAVFVLAIRFLIP 198
Cdd:PRK10504 170 nIPVGIIGAIATLMLMP 186
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
29-438 |
7.13e-10 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 60.41 E-value: 7.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 29 ALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTA 108
Cdd:cd17333 2 YISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFAT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 109 GDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPaSRRGKYIALMDGFWPLGFVAAGCL-SYFLLPLTGWRSIFLVLALpA 187
Cdd:cd17333 82 PSIYLFVVLMFLAGLGAGILDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIaTSLLTSELSWSWAYLIIGL-I 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 188 VFVLAIRFLIPESPrwleqagrreqadrvlrdiearvmrslgltelPPPLRQPQRERSRPGFFSAFAELWSPayrrrtlt 267
Cdd:cd17333 160 YLLLAILILLTLFP--------------------------------ELPSARNPQQSVGAFSASASRLLRNP-------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 268 vwGLWFFALLGF------YGLTSWLSALLQQSGF-AVTQSVYYTVLISLAGIPGFLCAAWLVESwgRKPSCVLMLLGGGA 340
Cdd:cd17333 200 --SIILGALALFlyvgaeTAFSSWVPSYLVEKKHvSDGLAGYLLSGFWVGITIGRLLGGPISRR--IKPHTLLVLSGSGA 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 341 MAYAYgqTAVFGGSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSArATGSGFASAVGRIGSLLGPLVTGLVLPLTGQ 420
Cdd:cd17333 276 LLGLL--ILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAK-GKGTSVLLAAGSIGGAIIPFIMGFIAEAVGI 352
|
410
....*....|....*...
gi 15598663 421 GGVFTLGALCFGVAALVV 438
Cdd:cd17333 353 QTAMLLITILYAIIFVLA 370
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
24-202 |
1.34e-09 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 59.51 E-value: 1.34e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 24 VFVIIALAFFFDSMDLAMMTFLLGSIKaEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASY 103
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFN-KLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 104 LCSTAGDLDSLTFYRVLLGIGMGmEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFLVL 183
Cdd:cd17330 80 LLGLSRNLWLLFLARFLDGLTGG-NVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVA 158
|
170 180
....*....|....*....|
gi 15598663 184 A-LPAVFVLAIRFLIPESPR 202
Cdd:cd17330 159 AaLALLNLVLVLFFLPPLRR 178
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
25-198 |
1.59e-09 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 59.51 E-value: 1.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 25 FVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYL 104
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 105 CSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFLVLA 184
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160
|
170
....*....|....
gi 15598663 185 LPAVFVLAIRFLIP 198
Cdd:cd17323 161 IISGFCLILIFLFL 174
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
42-441 |
1.97e-09 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 59.21 E-value: 1.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 42 MTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTF-YRVL 120
Cdd:cd17355 22 FGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLlWGLL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 121 LGIGMGMEFPIAQSLLSEMIPASRRGKYIALMdgfwplgFVAAGCLSYFLLPLT-------GWRSIFLVLALPAVFVLAI 193
Cdd:cd17355 102 GGGGAGTLAAVAFATVAAWWFERRRGLALGIL-------TAGGGLGSLVFLPLGaalieafGWRTALLVLALLALLVLVP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 194 RFLipesprwleqagrreqadrvlrdiearvmrsLGLTELPPPLRQPQRERSRPGFFSAFAELW-SPAYRRRTLTVwglw 272
Cdd:cd17355 175 VLL-------------------------------LLRRRPADLALRAYDDASPASPGSTLKEALrSASFWLLALAF---- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 273 FFALLGFYGLTSWLSALLQQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPSCVLMLLGGGAMAYAYgqtAVFG 352
Cdd:cd17355 220 FLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALL---LLLP 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 353 GSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLVLPLTGQ-GGVFTLGALCF 431
Cdd:cd17355 297 FPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSyTAAWALAVALG 376
|
410
....*....|
gi 15598663 432 GVAALVVWAF 441
Cdd:cd17355 377 LIAALLVLPI 386
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
47-441 |
3.02e-09 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 58.52 E-value: 3.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 47 GSIKAEFGL---DSAQAGLLASSSFFGMVIGAALSGMLAD-RFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVLLG 122
Cdd:cd17378 19 VSIVSEWGLicaGSFLVGLPQSSFFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 123 IGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYflLPLTGWRSIFLVLALPAVFVLAIRFLIPespr 202
Cdd:cd17378 99 FGRSGIGTCALVLATEPVGPKWRGQVGMSTFFFFVLGFMSLPGIAY--LNGSSWRVLYFWTSIPALIYCILVYLFA---- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 203 wleqagrreqadrvlrdiearvmrslgltelppplrqpqrersrpgffsafaelwspayrRRTLTVWGLWFFALLGFYGL 282
Cdd:cd17378 173 ------------------------------------------------------------RRLLAVMVIGFGIGMVYYGI 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 283 TSWLSALlqqsGFAVTQSVYYTVLISLagiPGFLCAAWLVESWGRKPSCVLMLLGGGAmAYAYGQTAVFGGSLALLIGFG 362
Cdd:cd17378 193 PLAVGNL----KFNIYLSVALNALSEL---PAFVITAFLLDRFGRRPSLLGFTLLSGA-SCLLCFVLSIGGTTSLQIALE 264
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15598663 363 LAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLvlpltGQGGVFTLGALcFGVAALVVWAF 441
Cdd:cd17378 265 LVGFFGAAGAFNLLYIYTVELFPTCVRNAALGMLRQALVVGGIFAPFIVSL-----GRKNAALSFGV-FGVAILLLGLF 337
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
6-197 |
4.08e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 58.01 E-value: 4.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 6 ASAAERLERLPLSPYHRLVFVIIALAFFFDSMDLAMMTFLlgsIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRF 85
Cdd:cd06173 195 RDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLL---AKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRR 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 86 GRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGK----YIALMDGFWPLGFV 161
Cdd:cd06173 272 RRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRvfsvYNALNSGAMPLGAL 351
|
170 180 190
....*....|....*....|....*....|....*.
gi 15598663 162 AAGclsyFLLPLTGWRSIFLVLALPAVFVLAIRFLI 197
Cdd:cd06173 352 LAG----LLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_GLUT8_Class3 |
cd17433 |
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
55-452 |
4.81e-09 |
|
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340991 [Multi-domain] Cd Length: 416 Bit Score: 57.96 E-value: 4.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 55 LDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQS 134
Cdd:cd17433 38 LDDAAASWFGSVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVPFIAGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPV 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 135 LLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLlpltGWRSIFLVLALPAVFVLAIRFLIPESPRWLEQAGRREQAD 214
Cdd:cd17433 118 YISEIAHPRVRGTLGSCVQLMVVIGIMGAYLAGLVL----DWRWLAVLGSIPPTLMLLLMCFMPETPRFLLTQHRRQEAM 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 215 RVLrdieaRVMRSLGLTELPPPLRQPQRERSRPGFFSaFAELWSPA-YRRRTLTVWGLWFFALLGFYGLTSWLSALLQQS 293
Cdd:cd17433 194 AAL-----RFLRGPDQGWEWECIGIEQSFHLEEQSFS-LALLKQPGiYKPLIIGVSLMAFQQLTGINAVMFYAETIFEEA 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 294 GFavTQSVYYTVLISLAGIPGFLCAAWLVESWGRKpscVLMLLGGGAMAYAygqTAVFGGSLALLIGFGLAMqfFLFGMW 373
Cdd:cd17433 268 KF--KDSSVASVIVAAIQVLFTAVAALIMDRAGRK---VLLVLSGVVMVFS---TAAFGWLAVGSMGFFIAG--FAVGWG 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 374 AVLYTYTPELYPTSARATGSGFASAVG-RIGSLLGPLVTGLVLPLTGQGGVFTLGALCfgVAALVVWAFGI-ETRGRTLE 451
Cdd:cd17433 338 PIPWLVMSEIFPLHVRGVASGICVLTNwLMAFLVTKEFSSLMEVLSSYGTFWLFSAFC--AFSVLFTLFCVpETKGKTLE 415
|
.
gi 15598663 452 E 452
Cdd:cd17433 416 Q 416
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
31-443 |
5.28e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 57.99 E-value: 5.28e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 31 AFFFDSMDLAMMTFLLGSIKAEFGLDSAQAG-LLASSSFFGMVIgAALSGMLADRFG-----RKPVFQASIVLWGLASYL 104
Cdd:COG2211 19 DLGLNLAFGLLSAYLLYFYTDVLGLSAALVGlILLVARLWDAIT-DPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 105 CSTAGDLDSLTFY------RVLLGIGMGMEFPIAQSLLSEMIPASR-RGKYIALMDGFWPLGFVAAGCLSYFLLPL---- 173
Cdd:COG2211 98 LFTAPDLSPTGKLiyalvtYLLLGLAYTLVNIPYSALGAELTPDYEeRTRLSSWRFAFAGLGGLLASVLPPPLVAAfggd 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 174 --TGWRSIFLVLALPAVFVLAIRFLipesprwleqagrreqadrvlrdiearvmrslGLTELPPPlrqpqrERSRPGFFS 251
Cdd:COG2211 178 aaLGYRLTALIFAVLGLLAFLLTFF--------------------------------GTKERPVP------EEEKVSLKE 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 252 AFAELWSPAYRRRTLTVWGLWFFALLGFYGLTswLSALLQQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKP-- 329
Cdd:COG2211 220 SLKALLKNRPFLLLLLAYLLFFLALALVAALL--LYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKaf 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 330 --SCVLMLLGGGAMAYAYGQTAVFGGSLALLIGFGLAMQFFLfgMWAVL-YTYTPELYPTSARATGSGFA--SAVGRIGS 404
Cdd:COG2211 298 iiGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVL--PWAMLaDVVDYDEWKTGRRREGLYFGifTFAIKLGQ 375
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 15598663 405 LLGPLVTGLVLPLTG---------------QGGVFTLGALCFGVAALVVWAFGI 443
Cdd:COG2211 376 ALAGALAGLLLALFGyvagaaqspsaltgiRLLFFLLPAVLLLLAALLLLFYPL 429
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
41-441 |
1.34e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 56.47 E-value: 1.34e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 41 MMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRV- 119
Cdd:cd06173 17 IFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLl 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 120 ----LLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFLVLALPAVFVLAIRF 195
Cdd:cd06173 97 vlafLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 196 LIpesprwleqagrreqadrvlrdiearvmrslgltelpPPLRQPQRERSRPGFFSAFAELWSPAYRRRTLTVWGLWFFA 275
Cdd:cd06173 177 FI-------------------------------------RRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALAL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 276 LLGFYGLTSWLSALLQQSGFAVTQSVYYTVL--ISLAGIPGFLCAAWLVESWGRKPSCVLMLLGGGAMAYAYGQTAVFGG 353
Cdd:cd06173 220 FALLGGALTVLLPLLAKEVLGGGAAGYGLLLaaFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 354 SLALLIGFGLAMQFFLFGMWAVLYTYTPELYptsaRATGSGFASAVGRIGSLLGPLVTGLVLPLTGQGGVFTLGALCFGV 433
Cdd:cd06173 300 LLAALFLLGLAGGLFNVPLNTLLQLRVPDEL----RGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLL 375
|
....*...
gi 15598663 434 AALVVWAF 441
Cdd:cd06173 376 AALLLLLL 383
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
48-198 |
2.89e-08 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 55.43 E-value: 2.89e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 48 SIKAEFGL---DSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVLLGIG 124
Cdd:cd17379 20 SIVTEFNLvceDAWKLDLFQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLF 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15598663 125 MGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFllpLTGWRSIFLVLALPAVFVLAIRFLIP 198
Cdd:cd17379 100 GKGGWMTGYVLVTEFVGSKYRRTVGIVYQMFFTLGLLILPGIAYF---IPHWRWLQLAVTLPNFLFLLYYWFIP 170
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
262-441 |
5.55e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 54.59 E-value: 5.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 262 RRRTLTVWGLWFFALLGFYGLTSWLSALLQQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPSCVLMLLGGGAM 341
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 342 AYAYGqtavFGGSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLVLPLTGQG 421
Cdd:COG2814 89 SLLCA----LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180
....*....|....*....|
gi 15598663 422 GVFTLGALCFGVAALVVWAF 441
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRL 184
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
27-410 |
5.55e-08 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 54.70 E-value: 5.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 27 IIALAFFFDSMDLAMMTFL--------LGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLW 98
Cdd:TIGR00710 1 KSAKAFALLLGCLSILGPLgidmylpaFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 99 GLASYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRS 178
Cdd:TIGR00710 81 ALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 179 IFLVLALPAVF-VLAIRFLIPESprwleqagrreqadrvlrdiearvmrslgltelppplrQPQRERSRPG-FFSAFAEL 256
Cdd:TIGR00710 161 IFAFLSLAGILlSALIFFILPET--------------------------------------LPYEARIQIStYFETFLLL 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 257 WspayrrRTLTVWGLWFFALLGFYGLTSWLSA----LLQQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPSCV 332
Cdd:TIGR00710 203 L------KSKMFWGYALIYGASFGGFFAFFSGapfvYIDIMGVSPSVFGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLR 276
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15598663 333 LMLLGGGAMAYAYGQTAVFG-GSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLV 410
Cdd:TIGR00710 277 MGLILFAVSAVLLEITAILGlGSWAMIIGPMMFVGIGNSMISSIAMAYALEDFPHVAGTASALFGTLRLVLGAIVGYLV 355
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
22-197 |
6.84e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 54.12 E-value: 6.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 22 RLVFVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLA 101
Cdd:cd17473 197 KRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALG 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 102 SYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLG-FVAAGCLSYFLLPLTGWRSIF 180
Cdd:cd17473 277 FLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGqFLSPLVLGPLVNLTGGLSGAF 356
|
170
....*....|....*..
gi 15598663 181 LVLALpAVFVLAIRFLI 197
Cdd:cd17473 357 LILGV-LALVLAIVLLL 372
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
33-400 |
1.07e-07 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 53.92 E-value: 1.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 33 FFDSMDLAMMTFLLGsiKAEFGLDSAQAGLLAS-----SSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCST 107
Cdd:cd17368 12 FFDFGVYGFFAVYIG--RLFFPSGSEFASLLLTfatfgVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIAL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 108 AGDLDS--------LTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFL--------L 171
Cdd:cd17368 90 APTYATigiaapllVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLLsltltaeaL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 172 PLTGWRSIFLVLALPAVFVLAIRFLIPEsprwleqagrreqadrvlrdiearvmrslgltelPPPLRQPQRERSRPGFFS 251
Cdd:cd17368 170 AEWGWRIPFFIGLLIIPLGLWLRRSLEE----------------------------------TEAFLERKARPTRRELFA 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 252 AFAELWSPAYRRRTLTVWGLWFFALLGFYGLTswlsALLQQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPSC 331
Cdd:cd17368 216 LLANNRRIILLGMLLVAGSTVTFYFTTVYTPT----YAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVL 291
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15598663 332 VLMLLGGGAMAYAYGQTAVFGGSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVG 400
Cdd:cd17368 292 LVITLAALVTLYPVFAWLTAAPSFGRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALA 360
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
21-197 |
1.28e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 53.37 E-value: 1.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 21 HRLVFVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGL 100
Cdd:cd17316 176 RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 101 ASYLCSTAGDLDS--LTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGfwpLGFVAAGCLSYFLLPLTGWRS 178
Cdd:cd17316 256 LALPLFYLLSGSPtlLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYN---LGRLGGGGAPPLIALLLASTG 332
|
170
....*....|....*....
gi 15598663 179 IFLVLALPAVFVLAIRFLI 197
Cdd:cd17316 333 GTGVPALILALLAIVALIV 351
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
43-442 |
1.73e-07 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 53.08 E-value: 1.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 43 TFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVLLG 122
Cdd:cd06180 19 TPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 123 IGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPL-TGWRSIFLVLALPAVFVLAIRFLipesp 201
Cdd:cd06180 99 AASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGgLSWRAGWLALALLSAVLLLLSFL----- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 202 rwleqagrreqadrVLRDIEARVmrslglTELPPPLRQPQRERSrpgffsafaeLWspayrrRTLTVWGLWFFallGFYG 281
Cdd:cd06180 174 --------------LLRRGPSAP------TEASAAESAPGLNRP----------LW------RLALAYGLFGF---GYII 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 282 LTSWLSALLQQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPSCVLMLLGGGAMAYAygqtAVFGGSLALLIGF 361
Cdd:cd06180 215 TATFLPLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLL----PLLSPGPAGLVLS 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 362 GLAMQFFLFGMWAVLYTYTPELYPtSARATGSGFASAVGRIGSLLGPLVTGLVLPLTgqGGVFT---LGALCFGVAALVV 438
Cdd:cd06180 291 AVLFGGTFMAITALVMALARELAP-PAAPRALALMTASFGVGQILGPLLAGWLADAT--GGFAPaliLAAAALVVAALLA 367
|
....
gi 15598663 439 WAFG 442
Cdd:cd06180 368 LLVL 371
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
2-202 |
1.87e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 52.96 E-value: 1.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 2 PDAPASAAERLERLPLSPYHRLVFVIIALAFFFDSMDLAMMTFLLGSI-KAEFGLDSAQAGLLASSSFFGMVIGAALSGM 80
Cdd:COG2223 184 PAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYlVDQFGLSAATAGLLAALFALLGALGRPLGGW 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 81 LADRFGRKPVFQASIVLWGLASYLCSTA-GDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLG 159
Cdd:COG2223 264 LSDRIGGRRVLLIVFALMALGLLLLALAlGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLG 343
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 15598663 160 FVAAGCLSYFLLPLTG-WRSIFLVLALPAVFVLAIRFLIPESPR 202
Cdd:COG2223 344 GFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRRPR 387
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
6-145 |
2.07e-07 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 52.91 E-value: 2.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 6 ASAAERLERLP----LSPYHRLVFVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQ---AGLLASSSFFGMVIgaaLS 78
Cdd:cd17369 208 AKEAGQVVRAPlvevLRRHWRALLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTvllAVLIASVVAAITIP---LF 284
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15598663 79 GMLADRFGRKPVFQASIVLWGLASY----LCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRR 145
Cdd:cd17369 285 GWLSDRVGRRPVYLAGALLAALFAFpffwLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVR 355
|
|
| MFS_GLUT10_Class3 |
cd17436 |
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
38-201 |
2.65e-07 |
|
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340994 [Multi-domain] Cd Length: 376 Bit Score: 52.50 E-value: 2.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 38 DLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFY 117
Cdd:cd17436 16 ELGIISGALLQLQTDFSLSCFEQEALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSLILTLAGSFFWLVIG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 118 RVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLP-LTGWRSIFLVLALPAVFVLAIRFL 196
Cdd:cd17436 96 RAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILISYALNYFFSNvLTGWRYMFGLAIIPAAIQFASILL 175
|
....*
gi 15598663 197 IPESP 201
Cdd:cd17436 176 LPKKP 180
|
|
| MFS_SLC22A16_CT2 |
cd17375 |
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ... |
263-408 |
3.01e-07 |
|
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340933 [Multi-domain] Cd Length: 341 Bit Score: 52.06 E-value: 3.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 263 RRTLTVWGLWFFALLGFYgLTSWLSALLQQSGFavtqsvYYTVLISLAGIPGFLCAAWLVESWGRKPSCVLMLLGGGAMA 342
Cdd:cd17375 173 KRTITVWLIWFTGSLGYY-VFSLGSVNLGGNEY------LNLFLVGAVEIPSYIIACIGMDKLGRRNTLAPFLLLSALAC 245
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 343 YAY----GQTAVFGGSLALLIGFGLAMQFflfgmwAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGP 408
Cdd:cd17375 246 MLImvipQDYEVLTIVLSMTGKFAIAIAF------GLIYLYTAELYPTIVRSLAVGSGSMMCRVGSVVAP 309
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
28-399 |
3.18e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 52.17 E-value: 3.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 28 IALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCST 107
Cdd:cd17478 1 LSLGHFLNDFYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 108 AGDLDSLTFYRVLLGIGMGMEFPIAQSLLSeMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFLVLALPA 187
Cdd:cd17478 81 APNYWLLLLLVALAGIGSAAFHPEGARLAS-QAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 188 VFVLairFLIPESPRWLEQAGRREQADRVLRDIEARVMRSLGLtelppplrqpqrersrpgffsafaelwspayrrrtlt 267
Cdd:cd17478 160 LAVA---LLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLL------------------------------------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 268 VWGLWFFALLGFYGLTSWLSALLQQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKP----SCVLMLLGGGAMAY 343
Cdd:cd17478 200 LLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRviiaSLLLAAPFLLLFLL 279
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 15598663 344 AYGQtavfgGSLALLIGFGlamqFFLFGMWAVLYTYTPELYPTSAratgsGFASAV 399
Cdd:cd17478 280 TPGI-----WSYILLVLAG----FLLFASFPVTVVLAQELLPGNV-----GLASGL 321
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
2-163 |
7.53e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 50.88 E-value: 7.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 2 PDAPASAAERLERLPLSPYHRLVFVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGML 81
Cdd:pfam07690 179 RPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 82 ADRFGRKP---VFQASIVLWGLASYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPL 158
Cdd:pfam07690 259 SDRLGRRRrllLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSL 338
|
....*
gi 15598663 159 GFVAA 163
Cdd:pfam07690 339 GGALG 343
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
26-204 |
7.96e-07 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 50.95 E-value: 7.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 26 VIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLC 105
Cdd:cd17435 4 VTAAVSGLLVGYELGIISGALLQLRTLLALSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 106 STAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSY-FLLPLTGWRSIFLVLA 184
Cdd:cd17435 84 VCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILLAYISNYaFANVSNGWKYMFGLVI 163
|
170 180
....*....|....*....|
gi 15598663 185 LPAVFVLAIRFLIPESPRWL 204
Cdd:cd17435 164 PLAALQAIAMYFLPPSPRFL 183
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
22-189 |
1.12e-06 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 50.27 E-value: 1.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 22 RLVFVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAG-LLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGL 100
Cdd:cd17330 174 PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGlLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAII 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 101 ASYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYI----ALMDGFWPLGFVAAGCLSYFLLPLTGW 176
Cdd:cd17330 254 GLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQgiiqSLQSLARIIGPLLAGPLYSFLGPGVPF 333
|
170
....*....|...
gi 15598663 177 RSIFLVLALPAVF 189
Cdd:cd17330 334 LLAAGLLLIALFL 346
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
229-430 |
1.28e-06 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 50.11 E-value: 1.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 229 GLTELPPPLRQPQRERSRPGFFSAFAELWSPayrRRTLTVWGLWFFALLGFYGLTswlsalLQQSGFAVtqSVYYT-VLI 307
Cdd:cd17446 140 GVAYAIRDWRWLQLAVSLPFFIFFLYSWWFP---RITFCLSLVWFSTSFAYYGLA------MDLQKFGV--SIYLIqIIF 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 308 SLAGIPGFLCAAWLVESWGRKPSCVLMLLGGGAMAYAYG----QTAVFGGSLALLIGFGLAMQFflfgmwAVLYTYTPEL 383
Cdd:cd17446 209 GAVDIPAKFISTLTMSYLGRRPTQAAALILAGIMILANIfvpqDLQTVRTALAVFGKGCLAASF------NCVYLYTGEL 282
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 15598663 384 YPTSARATGSGFASAVGRIGSLLGPLVTGL-----VLPLTGQGGVFTLGALC 430
Cdd:cd17446 283 YPTVIRQTGMGLGSTMARLGGIVAPLVKMLgeyypFLPLIIYGAAPILSGIA 334
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
5-197 |
1.28e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 50.26 E-value: 1.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 5 PASAAERLERLPLSPYHRLVFVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADR 84
Cdd:COG2807 197 AAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADR 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 85 FGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRR-GKYIALMDGFWPLGFVAA 163
Cdd:COG2807 277 LGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEaAALSGMAQSVGYLLAALG 356
|
170 180 190
....*....|....*....|....*....|....*
gi 15598663 164 GCLSYFLLPLTG-WRSIFLVLALPAVFVLAIRFLI 197
Cdd:COG2807 357 PLLVGALHDATGsWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_GLUT_Class1 |
cd17431 |
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
63-399 |
1.64e-06 |
|
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340989 [Multi-domain] Cd Length: 445 Bit Score: 50.03 E-value: 1.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 63 LASSSF-FGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYL---CSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSE 138
Cdd:cd17431 54 LSVAIFsVGGMIGSFSVGLFVNRFGRRNSMLYNNLLAFAGAALmglSKLAKSYEMLILGRFIIGLYCGLTTGLVPMYIGE 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 139 MIPASRRGKyialMDGFWPLGFVAAGCLSYFL-LPL-----TGWRSIFLVLALPAVFVLAIRFLIPESPRWL-EQAGRRE 211
Cdd:cd17431 134 ISPTALRGA----LGTLHQLGIVVGILISQIFgLEFilgteELWPLLLGFTIVPAILQLALLPFCPESPRYLlINRNEEE 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 212 QADRVLRDIEARVMRSLGLTELPPPLRQPQRERsRPGFFSAFAelwSPAYRRRTLTVWGLWFFALL-GFYGLTSWLSALL 290
Cdd:cd17431 210 EAKSVLKKLRGTTDVSEDIQEMKEESRQMMREK-KVTILELFR---SSSYRQPIIIAIVLQLSQQLsGINAVFYYSTSIF 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 291 QQSGfaVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKpscVLMLLGGGAMAyayGQTAVFGGSLALLIGFGLA------ 364
Cdd:cd17431 286 EKAG--VQQPVYATIGAGVVNTIFTVVSLFLVERAGRR---TLHLIGLGGMA---ICAILMTIALLLLEGYPWMsyvsiv 357
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 15598663 365 -----MQFFLFGMWAVLYTYTPELYPTSARatGSGFASAV 399
Cdd:cd17431 358 aifgfVAFFEIGPGPIPWFIVAELFSQGPR--PAAMAVAG 395
|
|
| MFS_GLUT6_Class3 |
cd17434 |
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
67-452 |
2.97e-06 |
|
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340992 [Multi-domain] Cd Length: 417 Bit Score: 49.45 E-value: 2.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 67 SFFGMV--IGAALSGM----LADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMI 140
Cdd:cd17434 44 SWFGSVftLGAAAGGLsamfLNDRLGRKLSIMFSAVPSALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIPVYVSEIS 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 141 PASRRGkyialMDGFWPLGFVAAGCLSYFLLPLT-GWRSIFLVLALPAVFVLAIRFLIPESPRWLEQAGRREQADRVLRD 219
Cdd:cd17434 124 HPGVRG-----ALGACPQIMAVFGSLALYALGLLlPWRWLAVAGEVPVVIMILLLCFMPNSPRFLISKGKDEKALKALAW 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 220 IEARVmrslglTELPPPLRQPQRERSRPGFFSAFAELWSPAYRRRTLTVWGLWFFALLGfyGLTSWLSALlqQSGFAVTQ 299
Cdd:cd17434 199 LRGPN------TDYMTEFEQIKDNIRKQSSRLSWAELKTPSYYKPILIAVVMRFLQQLT--GITPILVYL--EPIFHLTA 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 300 SV----YYTVLISLAGIPGFLCAAWLVESWGRKpscVLMLLGGGAMAYAYGQTAVFGGSLALLIGFGLAMqfflfGMWAV 375
Cdd:cd17434 269 VIlepkYDAALVGAVRLLSVAIAASLMDKAGRK---ILLFTSAFLMFAANLSMGLIPLIAAMLFIMGYAM-----GWGPI 340
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15598663 376 LYTYTPELYPTSARATGSGFASAVGRI-GSLLGPLVTGLVLPLTGQGGVFTLGALCfgVAALVVWAFGI-ETRGRTLEE 452
Cdd:cd17434 341 TWLLMSEILPLKARGVASGLCVVVSWItAFVLTQLFLPVVVTFGLQVPFLFFAAVC--AVSIIFTACCVpETKGRTLEQ 417
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
39-443 |
4.15e-06 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 48.73 E-value: 4.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 39 LAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGdLDSLTFYR 118
Cdd:cd17339 15 ITSVGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLGG-IALLFLGT 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 119 VLLGIGMGmefpIAQSLLSEMIPASrRGKYIALMDGFWPLGFVAAGCL-SYFLLPLT-----GWRSIFLVLALPAVFVLA 192
Cdd:cd17339 94 ALAGAGIA----VGNVLLPSLIKRD-FPRRVGLMTGLYTTSMNLGAALaSGLSVPLAqalggGWRGALAIWALPALLALL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 193 IrflipesprWLEQAGRREQADRVlrdiearvmrslgltelppplRQPQRERSrpgffsafaeLWspayrRRTLTVWGLW 272
Cdd:cd17339 169 I---------WLPQLRRRKRAAAA---------------------AAPLTKIS----------VW-----RSPLAWQVTL 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 273 FFAL--LGFYGLTSWLSALLQQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVeswGRKPSCVLMLLGGGAM-AYAYGQTA 349
Cdd:cd17339 204 FMGLqsLLFYTLMAWLPTILIDAGLSAATAGWLLSLFQLVGIPASLLVPILA---TRLKNQRPIVVLLAVLfIIGVLGLL 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 350 VFGGSL----ALLIGFGLAMQFFLFGMWAVLYTytpelyPTSARATG-SGFASAVGRIGSLLGPLVTGLVLPLTGQggvF 424
Cdd:cd17339 281 FAPTALallwAVLLGLGGGAAFSLALTLISLRS------SDPAEAAAlSGMAQSVGYLLAALGPLLFGVLHDLTGS---W 351
|
410
....*....|....*....
gi 15598663 425 TLGALCFGVAALVVWAFGI 443
Cdd:cd17339 352 TAPLVLLLALTVLQLVAGL 370
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
39-202 |
4.23e-06 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 48.74 E-value: 4.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 39 LAMMTFL--------LGSIKAEFGLDSAQAGllASSSFF--GMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTA 108
Cdd:PRK11043 14 LSMLGFLatdmylpaFKAIQADLQTSASAVS--ASLSLFlaGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 109 GDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIA-LMdgfwPLgfVA-----AGCLSYFLLPLTGWRSIFLV 182
Cdd:PRK11043 92 ESAAQLLVLRFVQAVGVCSAAVIWQALVIDRYPAQKANRVFAtIM----PL--VAlspalAPLLGAWLLNHFGWQAIFAT 165
|
170 180
....*....|....*....|
gi 15598663 183 LALPAVFVLAIRFLIPESPR 202
Cdd:PRK11043 166 LFAITLLLILPTLRLKPSKK 185
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
27-437 |
5.83e-06 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 48.41 E-value: 5.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 27 IIALAFFFDSMDLAMMTF--LLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYL 104
Cdd:cd17393 1 RLAVAAFFFINGILMASWatRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 105 CSTAGDLDSLTFYRVLLGIGMGMeFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLT---GWRSIFL 181
Cdd:cd17393 81 LGLAPSVPALALALFLFGAANGA-LDVAMNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLGAAAIGAGvspGVHLLAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 182 VLALPAVFVLAIRFLIPesPRWLEQAGRREQADRVLRDIEARVMRSLGLTelppplrqpqrersrpGFFSAFAE----LW 257
Cdd:cd17393 160 AVLLLLAALVAIRALLP--GTGEAAEDRPDGAGKPGFLLPNRLLLLLGLL----------------ALAAALAEgaaaDW 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 258 SPAYRRRTLtvwglwffallgfygLTSWLSALLQQSGFAVTQSVyytvlislagipGFLCAAWLVESWGRkpscVLMLLG 337
Cdd:cd17393 222 SALYLRDVL---------------GASAALAALGYAVFSLAMTV------------GRLFGDRLVDRFGD----VAVLRA 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 338 GGAMAYAYGQTAVFGGSLAL------LIGFGLAMQFflfgmwAVLYTYTPELyPTSARATGSGFASAVGRIGSLLGPLVT 411
Cdd:cd17393 271 GALLAALGLLLALLAPSVWValagfaLMGLGLSVVV------PLAFSAAGAL-PGLAAGIAVARVATLGYLGFLVGPPLI 343
|
410 420
....*....|....*....|....*.
gi 15598663 412 GLVLPLTGQGGVFTLGALCFGVAALV 437
Cdd:cd17393 344 GFLADATGLRTAFLVVALLALLVALL 369
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
24-198 |
7.32e-06 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 47.93 E-value: 7.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 24 VFVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADR--FGRKPVFQASIVLWGLA 101
Cdd:cd17352 184 TFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLILGLS 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 102 SYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTG-WRSIF 180
Cdd:cd17352 264 LLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGdYDAAF 343
|
170
....*....|....*...
gi 15598663 181 LVLALPAVFVLAIRFLIP 198
Cdd:cd17352 344 YFCGACLLLSGVLLFLLP 361
|
|
| MFS_SLC22A7_OAT2 |
cd17447 |
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ... |
48-410 |
7.83e-06 |
|
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341005 [Multi-domain] Cd Length: 341 Bit Score: 47.80 E-value: 7.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 48 SIKAEFGLDSAQAGL-LASSSFF--GMVIGAALSGMLADRFGRKPVFQASIVL---WGLASYLCSTagdLDSLTFYRVLL 121
Cdd:cd17447 22 TIATEWDLVCDRKGLnQATATFFfaGVTMGAVAFGYLSDRFGRKRMLLVAYVLslvFGLASAFSVS---YVMFAITRTLT 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 122 GIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFllpLTGWRSIFLVLALPAVFVLAIRFLIPesp 201
Cdd:cd17447 99 GFALTGFSIISMVLCVEWVDIEHRTVAGVLISLFWTVGNMLLALVAYL---IRDWRWLILAVTLPCAPGIITWWWVP--- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 202 rwleqagrreqadrvlrdieaRVMRSLGLTelppplrqpqrersrpgffsafaelwspayrrrtltvwglWFFALLGFYG 281
Cdd:cd17447 173 ---------------------KISLCTGIV----------------------------------------WFGVAFTYYG 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 282 LTswlsalLQQSGFAVtqSVYYTVLISLA-GIPGFLCAAWLVESWGRKPSCVLMLLGGGAmayAYGQTAVFGGSLALL-- 358
Cdd:cd17447 192 IS------FNISGFGL--NVYLTQFIYGAiELPAKLLAYLLLDRIGRRLTQAGSLILTGL---SIGINILIPSEFTVVrt 260
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 15598663 359 ----IGFGLAMQFFlfgmwAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLV 410
Cdd:cd17447 261 viavLGKGFSEAAF-----TTVFLYTSELYPTVLRQNGMGYTSFIARLGGSLAPLV 311
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
79-439 |
9.54e-06 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 47.60 E-value: 9.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 79 GMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVLLGIGmgmefPIAQ---SLLSEMIPASRRGKYIALMDGF 155
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSG-----AISSvvmALLADLTREENRTKAMALIGAS 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 156 WPLGFVAAGCLSYFLLPLTGWRSIFLVLALPAVFVLAIRFLIpesprwleqagrreqadrvlrdiearvmrslglteLPP 235
Cdd:cd17472 128 IGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFF-----------------------------------VPD 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 236 PLRQPQRERSRPGFFSAFaeLWSPAYRRRTLTVWGLWFFALLGFYgltsWLSALLQQSGFAVTQS--VYYTVLIS--LAG 311
Cdd:cd17472 173 PPKIVQISEKEKKKLKKL--LKNKRLLRLDFSIFILHFVLMAFFY----ILPLLLTQLGGGKGQLwkVYLPAILIgfILM 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 312 IPGFLCAAWLVESWGRKPSCVLMLLGGGAMAYAYGQTAVFggslaLLIGFGLAMQFFLFgMWAVLYTYTPELYPTSARAT 391
Cdd:cd17472 247 VPFVIYAEKKGKMKQVFVSSILLIAVGFLLLLFAATSLWL-----LIIGLIIFFIGFNL-LEALLPSLVSKIAPKEYRGT 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 15598663 392 GSGFASAVGRIGSLLGPLVTGLVLPLTGQGGVFTLGALCFGVAALVVW 439
Cdd:cd17472 321 AMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLVSF 368
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
49-439 |
1.03e-05 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 47.62 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 49 IKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDS----LTFYRVLLGIG 124
Cdd:cd17345 29 LIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSATSsvglMFILLFLNGWF 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 125 MGMEFPIAQSLLSEMIPASRRGKYIalmdGFWPL-----GFVAAGC--LSYFLLPLTGWRSIFLVlalPAVFVLAIRFLI 197
Cdd:cd17345 109 QGMGWPPSGRTMVHWFSKKERGTWT----SIWNIshnvgGGLVGPLagLGLAIFGDGWWRGAFIF---PAIIAIIVAVIV 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 198 pesprWLEQAGRREqadrvlrdiearvmrSLGLtelpPPLRQpqrersrpgFFSAFAELWSPAYRRRTLTVW-------- 269
Cdd:cd17345 182 -----LFLGKDTPE---------------SEGL----PPIEE---------YKGDYPEEADGEEEEQELSAWeifvkyvl 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 270 ---GLWFFALLGF------YGLTSWLSALLQQS-GFAVTQSVYYTVLISLAGIPGFLCAAWL---VESWGRKPSCVLMLL 336
Cdd:cd17345 229 knkLLWYIAIANVfvylvrYGILDWAPTYLSEVkGFSKAQAMWAFSLFEWAAIPGTLLAGWLsdkLFKGRRAPTGIIFMI 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 337 GGGAMAYAYGQTAvfggSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRI-GSLLGPLVTGLVL 415
Cdd:cd17345 309 LVIVALIVYWLAP----NVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLgGSVLATALIGIIV 384
|
410 420
....*....|....*....|....*..
gi 15598663 416 PLTGQGGVFTL---GALCFGVAALVVW 439
Cdd:cd17345 385 DHFGWNGGFIVllaSCILAIIFLALVA 411
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
273-441 |
1.78e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 46.64 E-value: 1.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 273 FFALLGFYGLTSWLSALLQQS-GFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPSCVLMLLGGGAMAYAygqtAVF 351
Cdd:pfam07690 6 FLAALGRSLLGPALPLLLAEDlGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL----LLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 352 GGSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLVLPLTGQGGVFTLGALCF 431
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
170
....*....|
gi 15598663 432 GVAALVVWAF 441
Cdd:pfam07690 162 LLAAVLLLLP 171
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
26-439 |
2.12e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 46.38 E-value: 2.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 26 VIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFG-RKPVFQASIVLWGLASYL 104
Cdd:cd17370 2 WLLGLVSLFADISYEMARSILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 105 CSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGW--RSIFLV 182
Cdd:cd17370 82 LALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGnyRTIFLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 183 LALPAVFVLAIRFLIPESPRwleqagrreqadrvlrdiearvmRSLGLTELPPPLRQPQRERSRPGFFSAFAelwspayr 262
Cdd:cd17370 162 AAIPALLALLILLFVVKEYP-----------------------RPPKLRKKSKKTSLKKLPKAFWLYLLAVA-------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 263 rrtLTVWGLWFFALLGFYGLTSWLSALLQQSGFAVtqsvyYTVLISLAGIPgflcAAWLVESWGRKpscVLMLLGGGAMA 342
Cdd:cd17370 211 ---LFALGNFSFAFLILRAQELGLSAALIPLLYAL-----FNLVYALAAYP----AGRLSDRIGRK---KLLILGYLSLA 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 343 YAYGQTAVFGGSLALLIGFGLAmqFFLFGMW-AVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLVLPLTGQG 421
Cdd:cd17370 276 LAYLGFALGSSLWLLLLGFILW--GLYMGAQeSIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPS 353
|
410
....*....|....*...
gi 15598663 422 GVFTLGALCFGVAALVVW 439
Cdd:cd17370 354 AAFLFSAVLALIALLLLL 371
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
20-198 |
1.09e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 44.37 E-value: 1.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 20 YHRLVFVIIALAFFFDSMDlAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLW- 98
Cdd:COG2270 237 YRDLLRFLLAYFFYRDGVQ-TVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWi 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 99 --GLASYLCSTAgdldsLTFY--RVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIalmdGFWPLGFVAAGCLSYFLLPLT 174
Cdd:COG2270 316 vvCLAAYFLTTA-----LAFWilGLLIGLVMGGIQALSRSLLARLIPPGREAEFF----GLYALSGKAASFLGPLLFGLV 386
|
170 180
....*....|....*....|....*..
gi 15598663 175 GW---RSIFLVLALPAVFVLAIRFLIP 198
Cdd:COG2270 387 TQltgSQRLGILSLIVFFVIGLVLLLR 413
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
23-200 |
1.38e-04 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 43.78 E-value: 1.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 23 LVFVIIALafffDSMDLAMMTFLLGSIKAEFGLDSAQA----GLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLW 98
Cdd:cd17388 3 FILVTVLL----DAMGIGLIMPVLPTLLREFVGDSADAathyGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 99 GLASYLCSTAGDLDSLTFYRVLLGIgMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLtGWRS 178
Cdd:cd17388 79 ALDYLLMAFAPTLWWLYLGRIIAGI-TGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEI-SPRA 156
|
170 180
....*....|....*....|...
gi 15598663 179 IFLVLA-LPAVFVLAIRFLIPES 200
Cdd:cd17388 157 PFLVAAgLNGLNFLLGLFVLPES 179
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
22-193 |
1.99e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 43.57 E-value: 1.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 22 RLVFVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADR-FGRKPVFQASIVLWGL 100
Cdd:cd06174 203 PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMAL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 101 ASYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGF-WPLGFVAAGCLSYFLLPLTGWRSI 179
Cdd:cd06174 283 GLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFgFLGGAIGPLLAGFLLAATFGLTGA 362
|
170
....*....|....
gi 15598663 180 FLVLALPAVFVLAI 193
Cdd:cd06174 363 FLVLAVLLLLAAIL 376
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
235-439 |
2.36e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 43.22 E-value: 2.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 235 PPLRQPQRERSRPGFFSAFAELWS--PAYRRRTLTVWGLWFFALL--GFYGLTSWLSALLQQS-GFAVTQSVYYTVLISL 309
Cdd:COG2270 206 PERPRPGPAPPRGAVRAGFRELRRtlRELRRYRDLLRFLLAYFFYrdGVQTVIAFAGIYAAGVlGFSTTELIVFGLLVQI 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 310 AGIPGFLCAAWLVESWGRKPS---CVLMLLGGGAMAYAYGQTAVFGGsLALLIGFGLAmqfflfGMWAVLYTYTPELYPT 386
Cdd:COG2270 286 VAALGALLFGRLDDRIGPKRVilvSLVIWIVVCLAAYFLTTALAFWI-LGLLIGLVMG------GIQALSRSLLARLIPP 358
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 15598663 387 SARATGSGFASAVGRIGSLLGPLVTGLVLPLTG--QGGVFTLGALcFGVAALVVW 439
Cdd:COG2270 359 GREAEFFGLYALSGKAASFLGPLLFGLVTQLTGsqRLGILSLIVF-FVIGLVLLL 412
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
2-193 |
4.12e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.53 E-value: 4.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 2 PDAPASAAERLERLPLSPYHRLVFVIIALAFFfdsmDLAMMTFLLGSIKA-EFGLDSAQAGLLASSSFFGMVIGAALSGM 80
Cdd:cd17370 181 PRPPKLRKKSKKTSLKKLPKAFWLYLLAVALF----ALGNFSFAFLILRAqELGLSAALIPLLYALFNLVYALAAYPAGR 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 81 LADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGF 160
Cdd:cd17370 257 LSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGW 336
|
170 180 190
....*....|....*....|....*....|...
gi 15598663 161 VAAGCLSYFLLPLTGWRSIFLVLALPAVFVLAI 193
Cdd:cd17370 337 LLASLIAGYLWDLISPSAAFLFSAVLALIALLL 369
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
45-441 |
4.35e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 42.24 E-value: 4.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 45 LLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAG-DLDSLTFYRVLLGI 123
Cdd:cd17341 21 LGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVsSYWGLLVLGFLLGF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 124 GMGMeFPIAQSLLSEMIPASRRGKYIALMDGFWPLGfvaaGCLSYFLLPL-----------TGWRSIFLVLALPAVfVLA 192
Cdd:cd17341 101 AGAN-FASGQPWASFWFPKEKIGGAAGGIAGAGNMG----VAVSQLLAPLiagaivfdggfVGWRNAFFVPGILLA-IAA 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 193 IRFLIpesprwleqagrreqadrVLRDIearvmrslgltelppplrqPQRERSRPGFFSAFaelwspayrRRTLTVWGLW 272
Cdd:cd17341 175 VLVLL------------------FGDDL-------------------PTGKASALEFLKVQ---------LAVLKNYRTW 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 273 FFALL------GFYGLTSWLSALLQ-QSGFAVTQSVYYTVLISLAG-----IPGFLC-----AAWLVESWgrkpscVLML 335
Cdd:cd17341 209 ILSLLygvtfgSFVGFSNVLPTYFKtRFGLPLVTAGILAALFPLAGalarpAGGWLSdrfggRRRLWWLF------IVMT 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 336 LGGGAMAYA-YGQTAVFGGSLALLIGFGLAMQF---FLFGMWAVLYtytpelypTSARATGSGFASAVGRIGSLLGPLVT 411
Cdd:cd17341 283 IGAALLSLSlPTSGTNLVLFLALFVALGLGAGAgngSVFRMVPFIF--------RRELGAVTGLVGAIGGLGGFFLPLLF 354
|
410 420 430
....*....|....*....|....*....|
gi 15598663 412 GLVLPLTGQGgvfTLGALCFGVAALVVWAF 441
Cdd:cd17341 355 GSSALMTGSG---VGAFSLFGVLAVACTLL 381
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
1-144 |
4.53e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.16 E-value: 4.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 1 MPDAPASAAERLERLPLSPYHRLVFVIIALAFFFDSMDLAMMTFLLGSIKAEfGLDSAQAGLLASSSFFGMVIGAALSGM 80
Cdd:cd17478 174 KPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQR-GYSLVFAGLLLSLFLFAGAIGTLIGGP 252
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15598663 81 LADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYrVLLGIGMGMEFPIAQSLLSEMIPASR 144
Cdd:cd17478 253 LSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILL-VLAGFLLFASFPVTVVLAQELLPGNV 315
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
53-146 |
5.30e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 42.16 E-value: 5.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 53 FGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFY---RVLLGIGMGMEF 129
Cdd:cd17321 199 LGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLlpgLVLLGLGLGLFA 278
|
90
....*....|....*..
gi 15598663 130 PIAQSLLSEMIPASRRG 146
Cdd:cd17321 279 TPLTNAALSSVPKEKAG 295
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
43-197 |
6.28e-04 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 41.94 E-value: 6.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 43 TFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVLLG 122
Cdd:cd17343 23 SFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSGSSSVWVFSILWFLNG 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15598663 123 IGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLgfvaAGCLSYFLLPLT----GWRSIFLVLALPAVFVLAIRFLI 197
Cdd:cd17343 103 LAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNL----AGSLGPILATLLalsyGWRSTLSISGTVAVVMSVVCLLF 177
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
60-189 |
6.65e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 41.87 E-value: 6.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 60 AGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEM 139
Cdd:cd17391 242 SGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKI 321
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 15598663 140 IPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFLVLALPAVF 189
Cdd:cd17391 322 TPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLL 371
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
64-202 |
6.80e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 41.82 E-value: 6.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 64 ASSSFFGMVIGA-ALS--------GMLADRFG-RKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVLLGIGMGMeFPIAQ 133
Cdd:cd17490 28 ASLSMIGIILGAyGISqmllriplGILSDRIGkRKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAAT-WVSFT 106
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15598663 134 SLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFLVLALPAVFVLAIRFLIPESPR 202
Cdd:cd17490 107 VLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERR 175
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
20-197 |
8.33e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 41.40 E-value: 8.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 20 YHRLVFVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRF---GRKPVFQASIV 96
Cdd:cd17319 177 YLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrgARRLVIIIGLL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 97 LWGLASYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPL-GFVAAGCLSYFLLPLTG 175
Cdd:cd17319 257 LAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLgGFVAPLLIGYLVDATGS 336
|
170 180
....*....|....*....|..
gi 15598663 176 WRSIFLVLALPAVFVLAIRFLI 197
Cdd:cd17319 337 YTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
43-437 |
8.47e-04 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 41.59 E-value: 8.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 43 TFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGA--ALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVL 120
Cdd:pfam06779 13 TPILPVMIAEGQFSLSQAGLLAAANYAGYLAGAllASFAWRHGASRLRPALLAGLLATVLLLLAMAATSSFWAVLLIRFL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 121 LGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLtGWRSIFLVLA---LPAVFVLAIRFLI 197
Cdd:pfam06779 93 AGVASAAVMIFGSSLILGHATAARRAFVGALLFAGVGIGIALSGLLVPLGLQL-GLGGSSLWYGagvLSAVLTLAVFPLL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 198 PesprwleqagrreqadrvlrdiearvmrslgltelppplRQPQRERSRPGFfSAFAELWSPAYRRRTLtvwgLWFFALL 277
Cdd:pfam06779 172 P---------------------------------------RRAPRHASAPAP-AAKPLQRSLPLWILTL----AYGLAGF 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 278 GFYGLTSWLSALLQQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPSCVLMLLGGGAMAYAygqtAVFGGSLAL 357
Cdd:pfam06779 208 GYIITATFLPAMARDGFGGPAAAALFWSLFGLAAALGVLVWLRAAKRWGTRPALTAALLIQALGVLL----SLLSPSPAG 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 358 LIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATgSGFASAVGRIGSLLGPLVTGLvlpLTGQGGVFTLGALCFGVAALV 437
Cdd:pfam06779 284 LAVSSLLFGGTFMAITSLVMQLARELAPPAPRRL-LGLMTASFGIGQILGPLLASL---LTAATGGLTPALLLAAAALVL 359
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
52-202 |
9.03e-04 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 41.65 E-value: 9.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 52 EFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLC--STAGDLDSLTFYRVLLGIGMGMEF 129
Cdd:TIGR00894 70 NFKWSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIpwAAGGGIALVVFCRVIQGLAQGSVS 149
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15598663 130 PIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLT-GWRSIFLVLALPAVFVLAIRFLIP-ESPR 202
Cdd:TIGR00894 150 PATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWgGWPMIFYVFGIVGCAWSLLWFVFPaDDPS 224
|
|
| MFS_NIMT_like |
cd17409 |
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of ... |
45-442 |
1.11e-03 |
|
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli 2-nitroimidazole transporter (NIMT), also called YeaN, and similar proteins. NIMT confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. The NIMT-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340967 [Multi-domain] Cd Length: 374 Bit Score: 41.10 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 45 LLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTaGDLDSLTFYRVLLGIG 124
Cdd:cd17409 21 LLDTIRESFGLSTAQAGLLTTLPLLAFALFSPLAAKLARRYGLERSLFAALLLIAAGIALRST-GSVWALYLGTAIIGAG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 125 MGMEFPIAQSLLSEMIPASrrgkyIALMDGFWPLGF-VAAGCLSYFLLPLT-----GWRSIFLVLALPAVFVLAIrflip 198
Cdd:cd17409 100 IAIGNVLLPSLLKRDFPAR-----VATLTGAYALTMgVGAALGSALVVPLAqvlafGWQLALGAFLVFPLVAALI----- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 199 esprWLEQAGRREQADRVlrdiearvmrslglTELPPPLRqpqrersrpgffsafaELW-SPAYRRRTLtvwglwFFAL- 276
Cdd:cd17409 170 ----WLPQLRRHTSPAAD--------------TAKPPHGG----------------SVWrSPLAWQVTL------FLGLn 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 277 -LGFYGLTSWLSALLQQSGFAVTQSVYYTVLISLA-GIPGFLCAAWLVESWGRKP----SCVLMLLGGGAMAYAYGQTAV 350
Cdd:cd17409 210 sFIYYVLVGWLPSILTDAGYSAAQAGSLHGLLQLAtAVPGLLLIPVLARMKDQRLlavlVSLLGAVGLIGLLLAPSLAIL 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 351 FggslALLIGFGLAMQFFLFGMWAVLYTYTPelyptSARATGSGFASAVGRIGSLLGPLVTGLVLPLTGQ-GGVFTLGAL 429
Cdd:cd17409 290 W----VILFGFGSGAGFILGLAFIGLRTSSA-----HQAAALSGMAQCVGYLLAATGPMLVGALHDLTGSwSVPLLLCAA 360
|
410
....*....|...
gi 15598663 430 CFGVAALVVWAFG 442
Cdd:cd17409 361 LALLMAIFGLLAG 373
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
33-161 |
1.27e-03 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 40.67 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 33 FFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLD 112
Cdd:cd17390 6 FLDLFGVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLA 85
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 15598663 113 SLTFYRVLLGIgMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFV 161
Cdd:cd17390 86 LLFLSRIPLGI-FKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFI 133
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
20-216 |
2.14e-03 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 40.42 E-value: 2.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 20 YHRLVFVIIALAFFfdSMDLAMMTFLLGS-------IKAEFGlDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQ 92
Cdd:pfam06609 36 YYRSPRIIASFAAF--SLNVCATYFVLQAsasalpnILQDIG-QSENQGLFSTLWTMGQAVSILMMGRLTDRFGRRPFVI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 93 ASIVLWGLASYLCSTAGDLDSLTFYRVLLGIGMGmefPIAQSLLSEMIPASRRGKYIALMDGFWPLgFVAAGCLSYF--L 170
Cdd:pfam06609 113 ATHIIGLVGAIVGCTANKFNTLLAAMTLLGVAAG---PAGASPLFIGELMSNKTKFLGLLIVSAPT-IAMNGAGPYFgqR 188
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 15598663 171 LPLTG-WRSIFLVLALPAVF--VLAIRFLIPESPRWL--EQAGRREQADRV 216
Cdd:pfam06609 189 LAIQGnWRWIFYIYIIMSAIavLLIIIWYHPPSFAQLhgKKARKRDELAKL 239
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
21-193 |
2.18e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 40.09 E-value: 2.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 21 HRLVFVIIALAFFFDSMDLAMmTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWgL 100
Cdd:cd17314 2 WFVLYVSFLLSAMSTGFILSW-SLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMV-L 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 101 ASYLCSTAGDLDSLTFY--RVLLGIGMGMEFPIAQSLLSEMIPaSRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRS 178
Cdd:cd17314 80 AGYTYLSYVFNSFPLSYacFVFIGAGTGILYGSAVLVTTQYFP-DTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLAL 158
|
170
....*....|....*
gi 15598663 179 IFLVLALPAVFVLAI 193
Cdd:cd17314 159 VYTILGILAAIVLSV 173
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
251-454 |
2.42e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 39.79 E-value: 2.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 251 SAFAELWSPAYRRRTLTVWGLWFFALLGFYGLTSWLSALLQQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKP- 329
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRv 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 330 ---SCVLMLLGGGAMAYAygqtavfgGSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLL 406
Cdd:COG0477 82 lliGLLLFGLASLLCGLA--------PSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLAL 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 15598663 407 GPLVTGLVLPLTGQGGVFTLGALcFGVAALVVWAFGIETRGRTLEELA 454
Cdd:COG0477 154 GPLLGGLLVAALGWRWIFLINAP-LGLLALVLRLRLPESRGLLLALLA 200
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
25-193 |
2.67e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 39.95 E-value: 2.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 25 FVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLA-SY 103
Cdd:cd17355 212 FWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGlAL 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 104 LCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTG-----WRS 178
Cdd:cd17355 292 LLLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGsytaaWAL 371
|
170
....*....|....*
gi 15598663 179 IFLVLALPAVFVLAI 193
Cdd:cd17355 372 AVALGLIAALLVLPI 386
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
56-198 |
3.43e-03 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 39.76 E-value: 3.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 56 DSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDS--LTFYRVLLGIGMGMEFPIAQ 133
Cdd:cd17381 63 DAETQGWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAgyLIAVRALEGLGEGVTFPAMH 142
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15598663 134 SLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFLVLALPAV--FVLAIRFLIP 198
Cdd:cd17381 143 AMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLlwFFLWIWLVMP 209
|
|
| MFS_SLCO_OATP |
cd17336 |
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ... |
22-169 |
4.60e-03 |
|
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 39.14 E-value: 4.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 22 RLVFVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSffgmVIGAALSGMLADRFGRKP----VFQASIVL 97
Cdd:cd17336 2 KVFVVLLCLLGLLQGAVVSYFVSTITTIEKRFGLSSSQSGLILSAN----DIGQLLAVLLVSYFGGRGhrprWIGIGSIL 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15598663 98 WGLASYLCSTagdLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFW----PLGFV-AAGCLSYF 169
Cdd:cd17336 78 MGLGCFLLAL---PHFLFVGQFLLGIGSSPLYTLGITYIDDNVSKKNSPLYIGILYAMRvlgpALGFLlGSFLLRIY 151
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
15-129 |
5.11e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 39.10 E-value: 5.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 15 LPLSPYHRLVFVIIALAFFFDSMDLAMMTFLLGS-IKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQA 93
Cdd:cd17503 170 LDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLyLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLA 249
|
90 100 110
....*....|....*....|....*....|....*....
gi 15598663 94 SIVLWGLASYLCSTAG---DLDSLTFYRVLLGIGMGMEF 129
Cdd:cd17503 250 GLLLLALGTLLLAFLTpdtSLWLIILPLFIRGLGMGLVF 288
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
266-441 |
6.20e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 38.76 E-value: 6.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 266 LTVWGLWFFALLGFYGLTSWLSALLQQSGfAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKP----SCVLMLLGGGAM 341
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWffigGNLLGVVGSIVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 342 AYAYGQTAVFGGSLalLIGFGLAMQFFLFGMwavlytyTPELYPTSARATGSGFASAVGRIGSLLGPLVTGLVLPLTGQG 421
Cdd:cd06179 80 GTAKSVNMLIGGQA--LIGIGAGTQGLGAAV-------ASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAG 150
|
170 180
....*....|....*....|..
gi 15598663 422 --GVFTLGALCFGVAALVVWAF 441
Cdd:cd06179 151 wrWIFYINAIFNALALILLFFF 172
|
|
| BT1 |
pfam03092 |
BT1 family; Members of this family are transmembrane proteins. Several are Leishmania putative ... |
50-217 |
6.66e-03 |
|
BT1 family; Members of this family are transmembrane proteins. Several are Leishmania putative proteins that are thought to be pteridine transporters. One such protein Swiss:Q25272, previously termed (and is still annotated as) ORFG, was shown to encode a biopterin transport protein using null mutants, thus being subsequently renamed BT1. The significant similarity of ORFG/BT1 to Trypanosoma brucei ESAG10 (a putative transmembrane protein and another member of this family) was previously noted. This family also contains five putative Arabidopsis thaliana proteins of unknown function. In addition, it also contains two predicted prokaryotic proteins (from the cyanobacteria Synechocystis and Synechococcus).
Pssm-ID: 308617 Cd Length: 432 Bit Score: 38.87 E-value: 6.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 50 KAEFGLDSAQAGLLASSSFFGMVIgAALSGMLADRFG-----RKPVFQASIVL----WGLASYLCSTAGDLDSLTFYRVL 120
Cdd:pfam03092 17 KDRLGLDPARYQRLSGLATLPWSI-KPLYGMLSDGFAlfgyrRRWYLALSGLLggafWLLYGLLPASEASAPVAAAFIFL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 121 LGIGMGMEFPIAQSLLSEMIPASRR--GKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFLVLALPAVFVLAIRFLIP 198
Cdd:pfam03092 96 SSLGVAIVDVLVDALVSERARQSPTpgPSLQSWIWGCSAVGGIIGSVLSGPLLDTFKPQISFFVTAALQLLTCVVALLIK 175
|
170
....*....|....*....
gi 15598663 199 ESPRWLEQAGRREQADRVL 217
Cdd:pfam03092 176 ESSLGLPAKHEPKRPVPCL 194
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
60-175 |
7.90e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 38.36 E-value: 7.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 60 AGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVLLGIgMGMEFPIAQSLLSEM 139
Cdd:PRK09874 56 SGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGL-LGGFVPNANALIATQ 134
|
90 100 110
....*....|....*....|....*....|....*..
gi 15598663 140 IPASRRGkyialmdgfWPLGFVAAGCLSYFLL-PLTG 175
Cdd:PRK09874 135 VPRNKSG---------WALGTLSTGGVSGALLgPLAG 162
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
49-146 |
9.04e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 38.36 E-value: 9.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 49 IKAEFGLDSAQAGLLASSSFFGMVIGAALSGMLA-DRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTFYRVLLGIGMGM 127
Cdd:cd17490 221 IAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFyKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGI 300
|
90
....*....|....*....
gi 15598663 128 EFPIAQSLLSEMIPASRRG 146
Cdd:cd17490 301 LFPLLMSLSIEGVPAEQRS 319
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
11-196 |
9.95e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 37.97 E-value: 9.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 11 RLERLPLSPYhrlVFVIIALAFFFDSMDLAMMTFLLgsiKAEFGLDSAQAGLLAS-SSFFGMVIGAALSGMLADRFGRKP 89
Cdd:cd17331 202 RLLRLPGVAF---LLLVKLLSGLPIGMFQSMFSLVA---MDFFGLTPEENGYLMSyAGVLGMVVQGLLVGPLTKRFGERS 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598663 90 VFQASIVLWGLASYLCSTAGDLDSLTFYRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYF 169
Cdd:cd17331 276 LLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGA 355
|
170 180
....*....|....*....|....*..
gi 15598663 170 LLPLTGWRSIFLVLALPAVFVLAIRFL 196
Cdd:cd17331 356 LLQAYGFPSFGLLGAAINGLLTVYLLL 382
|
|
| |
