|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
10-357 |
1.04e-104 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 313.43 E-value: 1.04e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 10 RLACIYFFAMAGLVIGNLMGRIPALKEQTQLDERALGQALLGVGVGALTAFPLSGFLVQRIGSRSVVIGGCLIMLLVFPL 89
Cdd:cd17393 1 RLAVAAFFFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 90 LGLSQGWWQLALAFYVLGVSFAGMDVAMNIQAVDVERLLGKPCMSMLHGMYSLGCLV--GALSAAALAGLTPFWHFLILT 167
Cdd:cd17393 81 LGLAPSVPALALALFLFGAANGALDVAMNAQGVAVERAYGRPIMSSLHAMWSLGGLAgaLLGAAAIGAGVSPGVHLLAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 168 ALGLLSLPFFVRALLPPDPSKAGARK----GGGFTLPPRALLGLGLLILCAFVSEGGVADWSALFLHSVLDASERVAALG 243
Cdd:cd17393 161 VLLLLAALVAIRALLPGTGEAAEDRPdgagKPGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 244 FAAFSAAMVVGRLFGDRLRGRIDDAPLLRGLGSLATLGMLVALFSPWPALSIAGFGVVGLGLSVMVPIVISAAGNQPGID 323
Cdd:cd17393 241 YAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAGALPGLA 320
|
330 340 350
....*....|....*....|....*....|....
gi 15598728 324 PVIGVAAVSTVGYGGLLMGPPLIGLLAHEIGLRW 357
Cdd:cd17393 321 AGIAVARVATLGYLGFLVGPPLIGFLADATGLRT 354
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-357 |
1.84e-63 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 207.78 E-value: 1.84e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 1 MSEVNPRQGRLACIYFFAMAGLVIGNLMGRIPALKEQTQLDERALGQALLGVGVGALTAFPLSGFLVQRIGSRSVVIGGC 80
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 81 LIMLLVFPLLGLSQGWWQLALAFYVLGVSFAGMDVAMNIQAVDVERLLGKPCMSMLHGMYSLGCLV--GALSAAALAGLT 158
Cdd:COG0738 81 LLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLgpLLGGLLILLGLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 159 PFWH--FLILTALGLLSLPFFVRALLP----PDPSKAGARKGGGFTLPPRALLGLGLLILCAFVSEGGVADWSALFLHSV 232
Cdd:COG0738 161 LSWHlpYLILAVLLLLLALLFLRSKLPeieeEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 233 LDASERVAALGFAAFSAAMVVGRLFGDRLRGRIDDAPLLRGLGSLATLGMLVALFSPWPALSIAGFGVVGLGLSVMVPIV 312
Cdd:COG0738 241 LGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTI 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 15598728 313 ISAAGNQPGIDPVIGVAAVSTVGYGGLLMGPPLIGLLAHEIGLRW 357
Cdd:COG0738 321 FSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRA 365
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
13-355 |
5.93e-21 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 93.15 E-value: 5.93e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 13 CIYFFAmAGLVIGNLMGRIPALKEQTQLDERALGQALLGVGVGALTAFPLSGFLVQRIGSRSVVIGGCLIMLLVFPLLGL 92
Cdd:cd17333 2 YISFFS-NGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 93 SQGWWQLALAFYVLGVSFAGMDVAMNIQAVDVERLLGKPCMSMLHGMYSLGCLVGALSAAALAGLTPFWH--FLILTALG 170
Cdd:cd17333 81 TPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSwaYLIIGLIY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 171 LLSLPFFVRALLPPDPSKAGARKGGGFTLPP-------RALLGLGLLILCAFVSEGGVADWSALFLHSVLDASERVAALG 243
Cdd:cd17333 161 LLLAILILLTLFPELPSARNPQQSVGAFSASasrllrnPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 244 FAAFSAAMVVGRLFGDRLRGRIDDAPLLRGLGSLATLGMLVALFSPWPALSIAGFGVVGLGLSVMVPIVISAAGNQPGID 323
Cdd:cd17333 241 LSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYA 320
|
330 340 350
....*....|....*....|....*....|..
gi 15598728 324 PVIGVAAVSTVGYGGLLMGPPLIGLLAHEIGL 355
Cdd:cd17333 321 KGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGI 352
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-338 |
4.57e-14 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 72.70 E-value: 4.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 1 MSEVNPRQGRLACIYFFA--MAGLVIGNLMGRIPALKEQTQLDERALGQALLGVGVGALTAFPLSGFLVQRIGSRSVVIG 78
Cdd:COG2814 1 MPATPRRRWLALLALALGafLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 79 GCLIMLLVFPLLGLSQGWWQLALAFYVLGVSFAGMDVAMNIQAVDV--ERLLGKPcMSMLHGMYSLGCLVGALSAAALAG 156
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLvpPERRGRA-LGLLGAGLGLGPALGPLLGGLLAD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 157 LTPF-WHFLILTALGLLSLPFFVRALLPPDPSKAGARKGGGFT-LPPRALLGLGLLILCAFVSEGGVADWSALFLHSVLD 234
Cdd:COG2814 160 LFGWrWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRElLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 235 ASERVAALGFAAFSAAMVVGRLFGDRLRGRIDDAPLLRGLGSLATLGMLVALFSPWPALSIAGFGVVGLGLSVMVPIVIS 314
Cdd:COG2814 240 LSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQA 319
|
330 340
....*....|....*....|....*
gi 15598728 315 AAGNQ-PGIDPVIGVAAVSTVGYGG 338
Cdd:COG2814 320 LVAELaPPEARGRASGLYNSAFFLG 344
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-357 |
3.68e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 57.57 E-value: 3.68e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 11 LACIYFFAMAGLVIGNLMGRIPALKEQTQLDERALGQALLGVGVGALTAFPLSGFLVQRIGSRSVVIGGCLIMLLVFPLL 90
Cdd:COG2271 13 ALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 91 GLSQGWWQLALAFYVLGVSFAGMDVAMNIQAVDV--ERLLGKPcMSMLHGMYSLGCLVGALSAAALAGLTPF-WHFLILT 167
Cdd:COG2271 93 GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWfpPKERGRA-LGIFNAGGPLGGALAPPLLGWLLAAFGWrAAFLILG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 168 ALGLLSLPFFVRALLppdpskagarkgggftlpprallglgLLILCAFVSEGGVADWSALFLHSVLDASERVAALGFAAF 247
Cdd:COG2271 172 LPGLLLALLRFWLLA--------------------------LAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLP 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 248 SAAMVVGRLFGDRLRGRID--DAPLLRGLGSLATLGMLVALFSPWPALSIAGFGVVGLGLSVMVPIVISAAGNQPGIDPV 325
Cdd:COG2271 226 FLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKAR 305
|
330 340 350
....*....|....*....|....*....|...
gi 15598728 326 -IGVAAVSTVGYGGLLMGPPLIGLLAHEIGLRW 357
Cdd:COG2271 306 gTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
11-343 |
1.01e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 56.27 E-value: 1.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 11 LACIYFFAMAGLVIGNLMGrIPALKEQTQLDERALGQALLGVGVGALTAFPLSGFLVQRIGSRSVVIGGCLIMLLVFPLL 90
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPAL-PLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 91 GLSQGWWQLALAFYVLGVSFAGMDVAMNIQAVDV----ERLLGkpcMSMLHGMYSLGCLVGALSAAALAGLTPF-WHFLI 165
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWfppeERGRA---LGLVSAGFGLGAALGPLLGGLLASLFGWrAAFLI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 166 LTALGLLS-LPFFVRALLPPDPSKAGARKGGGFTLPPRALLGLGLLILCAFVSEGGVADWSALF-----LHSVLDASERV 239
Cdd:pfam07690 157 LAILSLLAaVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLtylplYQEVLGLSALL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 240 AALGFAAFSAAMVVGRLFGDRLRGRIDDAPLLR---GLGSLATLGMLVALFSPWPALSIAGFGVVGLGLSVMVPIVISAA 316
Cdd:pfam07690 237 AGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLlalLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALV 316
|
330 340
....*....|....*....|....*...
gi 15598728 317 GNQPGIDPV-IGVAAVSTVGYGGLLMGP 343
Cdd:pfam07690 317 SDLAPKEERgTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
53-357 |
6.33e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 54.12 E-value: 6.33e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 53 GVGALTAFPLSGFLVQRIGSRSVVIGGCLIMLLVFPLLGLSQGWWQLALAFYVLGVSFAGMDVAMNIQAVDV--ERLLGK 130
Cdd:cd17325 41 ALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIapPEERGR 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 131 pCMSMLHGMYSLGCLVGALSAAALAGLTPF-WHFLILTALGLLSLPFFVRALLPPDPSKAGA-------RKGGGFTLPPR 202
Cdd:cd17325 121 -AMGIFSSAIGLGFLIGPLLGGLLADALGYrAPFLVCAALALLALVLALLLLPEPRPPPNKRavsaarlRSGLRLLLRDR 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 203 ALLGLGLLILCAFVSEGGVADWSALFLHSVLDASERVAALGFAAFSAAMVVGRLFGDRLRGRIDDAPLLRGLGSLATLGM 282
Cdd:cd17325 200 RLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15598728 283 LVALFSPWPALSIAGFGVVGLGLSVMVPIVISAAGNQPGIDPV-IGVAAVSTVGYGGLLMGPPLIGLLAHEIGLRW 357
Cdd:cd17325 280 LLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRgTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFAT 355
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
54-357 |
4.93e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 51.06 E-value: 4.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 54 VGALTAFPLSGFLVQRIGSRSVVIGGCLIMLLVFPLLGLSQGWWQLALAFYVLGVSFAGMDVAMNIQAVDV--ERLLGKp 131
Cdd:cd17489 42 LAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIipPSRRGE- 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 132 CMSMLHGMYSLGCLVGALSAAALAGLTPFWhFLILTALGLLSLPFFVRALLPPDPSKAGARKGGGFTLPP----RALLGL 207
Cdd:cd17489 121 GIGYYGLATTLAMALGPALGLFLYQHLGFA-VLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRrlveKKVLPP 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 208 GLLILCAFVSEGGVADWSALFLHSVLDAserVAALGFAAFSAAMVVGRLFGDRLRGRIDDAPLLRGLGSLATLGMLVALF 287
Cdd:cd17489 200 ALILFLASIAYGAISTFLPLYAAERGIS---NAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSF 276
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15598728 288 SPWPALSIAGFGVVGLGLSVMVPIVISAAGNQPGIDPVIGVAAVSTVGY-GGLLMGPPLIGLLAHEIGLRW 357
Cdd:cd17489 277 AGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFdLGIGLGGLLLGLVAELFGYRA 347
|
|
| MFS_MFSD4 |
cd17395 |
Major facilitator superfamily domain-containing protein 4; The Major facilitator superfamily ... |
16-354 |
3.80e-06 |
|
Major facilitator superfamily domain-containing protein 4; The Major facilitator superfamily domain-containing protein 4 (MFSD4) subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The MFSD4 subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340953 [Multi-domain] Cd Length: 367 Bit Score: 48.29 E-value: 3.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 16 FFAMaGLVIGNLMGRIPALKEQTQLDERALGQALLGVGVGALTAFPLSGFLVQRIGSRSVVIGGCLIMLLVFPLLGLSQG 95
Cdd:cd17395 6 FFSF-GLSIAFLGPTLLDLACNTNSSLPQISWVFFSRQLGYLLGSALGGVFKRTLNSLWALFTSSLLIALVLAVIPFCKD 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 96 WWQLALAFYVLGVSFAGMDVAMNIQAVDVERLLGKPCMSMLHGMYSLGCLVGALSAAALAGltpfWHFLILtALGLLSLP 175
Cdd:cd17395 85 VKVLASVMAIAGLAMGCLDTGANMQIVRMWQKDSAPFLQVLHFSFGFGAFLAPLIADPFLS----YAYWIM-ALINLPVP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 176 FFVRALLPPDPSKAGARKGGGFTLPPRALLGLGLLILCAFV------SEGGVADWSALFLHSVLDASERVAALGFAAFSA 249
Cdd:cd17395 160 MAVLMLLSKERLLTCCSQRRRKNLRRAPYSFFAIHITGALFlfmyvgLEGAYGAFVYSYAVEKPGVGHKVAAYLPSLFWG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 250 AMVVGRLFGDRLRGRIDDAPL--LRGLGSLATLGMLVaLFSPWPALSIAGFGVVGLGLSVMVPIVISAAGNQPGIDPVig 327
Cdd:cd17395 240 TFTLGRLLSIPISSRMKPATMvvLNVVGVVVTSLVLL-LFSKSVVFLWIGTASLGLFLASTFPSMLSYTEDSLQYTGC-- 316
|
330 340
....*....|....*....|....*...
gi 15598728 328 VAAVSTVGYG-GLLMGPPLIGLLAHEIG 354
Cdd:cd17395 317 STTVLVTGAGlGEMVLPMLVGSIQPFQA 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
15-350 |
6.00e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 47.81 E-value: 6.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 15 YFFAMAGLVIGNLMGRIPALKEQTQLDERALGQALLGVGVGALTAFPLSGFLVQRIGSRSVVIGGCLIMLLVFPLLGLSQ 94
Cdd:cd06174 3 LGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 95 GWWQLALAFYVLGVSFAGMDVAMNIQAVDV--ERLLGKPCMSMLHGMYSLGCLVGALSAAALAGLTPFWHFLILTALGLL 172
Cdd:cd06174 83 SFWLLLLGRFLLGLGSGLIDPAVLALIADLfpERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 173 SLPFFVRALLPPDPSKAGARKGGGFTLPP-----------RALLGLGLLILCAFVSEGGVADWSALFLHSVLDASERVAA 241
Cdd:cd06174 163 LLAAILLLLVVPDPPESARAKNEEASSKSvlkllkrvlknPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 242 LGFAAFSAAMVVGRLFGDRLRGR-IDDAPLLRGLGSLATLGMLVALFSPWPALSIAGFGVVGLGLSVMVPIVISAAGNQP 320
Cdd:cd06174 243 LLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELF 322
|
330 340 350
....*....|....*....|....*....|.
gi 15598728 321 GIDPV-IGVAAVSTVGYGGLLMGPPLIGLLA 350
Cdd:cd06174 323 PPEIRgTAFGLLNTFGFLGGAIGPLLAGFLL 353
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
14-355 |
8.23e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 47.54 E-value: 8.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 14 IYFFAMAGLVIGN----LMGRIPALKEQTQLDERALGQALLGVGVGALTAFPLSGFLVQRIGSRSVVIGGCLIMLLVFPL 89
Cdd:cd17324 1 LLALALAAFAIGTteyvIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 90 LGLSQGWWQLALAFYVLGVS---FAGMDVAMNIQAVDVERLLGkpCMSMLHGMYSLGCLVGALSAAALAGL----TPFWH 162
Cdd:cd17324 81 AALAPSFALLLLARALAGLAhggFWAIAAAYAADLVPPEKRGR--AIGLVFSGLTLGLVLGRPLGGLLGQLlgwrAAFLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 163 FLILTALGLLSLPFFVRALLPPDPSKAGARKGGGFTLPPRALLGLGLLILCAFVSEGGVADWSALFLHSVLDASERVAAL 242
Cdd:cd17324 159 IAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 243 GFAAFSAAMVVGRLFGDRLRGRIDDAPLLRGLGSLATLGMLVALFSPWPALSIAGFGVVGLGLSVMVPIVISAAGNQPGI 322
Cdd:cd17324 239 LLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPE 318
|
330 340 350
....*....|....*....|....*....|...
gi 15598728 323 DPVIGVAAVSTVGYGGLLMGPPLIGLLAHEIGL 355
Cdd:cd17324 319 ARGLASSLYLAAYNLGGALGAALGGLVLDHGGW 351
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
56-354 |
3.79e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 45.26 E-value: 3.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 56 ALTAfPLSGFLVQRIGSRSVVIGGclimLLVFPLLGLSQGW----WQLALAFYVLGVSFAGMDVAMNIQAVDV------E 125
Cdd:cd17473 49 ALFA-PLAGWLADRFGRKRLLIAG----LLLYGIGGVAGLFldslYALLASRALLGIGVAGIMTLATALIGDYfegeerA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 126 RLLGKPCMSMlhgmySLGCLVGALSAAALAGLTPFWHFLILtALGLLSLPFFVRALLPPDPSKAGARKGGGFT---LPPR 202
Cdd:cd17473 124 KMLGLQSAAM-----SLGGVVFLLLGGALAEIGWRAPFLVY-LLALPVLILVLLFLPEPARKSKSAASPGAATaaaLPWK 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 203 ALLGLGLLILCAFVSEGGVADWSALFLHSVLDASERVAALGFAAFSAAMVVGRLFGDRLRGRIDDAPLLRGLGSLATLGM 282
Cdd:cd17473 198 RVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGF 277
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15598728 283 LVALFSPWPALSIAGFGVVGLGLSVMVPIVIS-AAGNQPGIDPVIGVAAVSTVGYGGLLMGPPLIGLLAHEIG 354
Cdd:cd17473 278 LLLALASGLWVVLLGAILAGLGFGLLLPTLNSwAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTG 350
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
34-124 |
4.98e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 44.87 E-value: 4.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 34 LKEQTQLDERALGQALLGVGVGALTAFPLSGFLVQRIGSRSVVIGGCLIMLLVFPLLGLSQGWWQLALAFYVLGVSFAGM 113
Cdd:cd17325 226 AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLV 305
|
90
....*....|.
gi 15598728 114 DVAMNIQAVDV 124
Cdd:cd17325 306 FPATLALLADI 316
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
46-312 |
1.44e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 43.37 E-value: 1.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 46 GQALLGVGVGALTAFPLSGFLVQRIGSRSVVIGGCLIMLLVFPLLGLSQGWWQLALAFYVLGVSFAGMDVAMNIQAVDVE 125
Cdd:cd17329 38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 126 RLLGKPCM-SMLHGMYSLGCLVGALSAAALAGLTPFWHFLILTALGLLSLPFFVRALLPPDPSKAGARKGGGFTLPP--- 201
Cdd:cd17329 118 TPENRTRAfSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKivl 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 202 --RALLGLGLLILCAFVSEGGVADWSALFLHSVLDASERVAALGFAAFSAAMVVGRLFGDRLRGRIDDAPLLRGLGSLAT 279
Cdd:cd17329 198 rdRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFA 277
|
250 260 270
....*....|....*....|....*....|...
gi 15598728 280 LGMLVALFSPWPALSIAGFGVVGLGLSVMVPIV 312
Cdd:cd17329 278 IGFAVLAFANTLAVLILAMIVLTLGEMLVFPAV 310
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
159-357 |
2.02e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 42.94 E-value: 2.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 159 PFWHFLILTALGLLSLPFFVR-ALLPPDPSKAGARKGGGFTLPPRALLGLGLLILCAFVSEGGVADWSALFLHSVLDASE 237
Cdd:cd17474 154 PFFLLAALIPVAFLAILFLLPePKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISP 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 238 RVAALGFAAFSAAMVVGRLF-GDRLRGRIDDAPLLRGLGSLATLGMLVALFSPWPALSIAGFGVVGLGLSVMVPIVISA- 315
Cdd:cd17474 234 IIIGLLFAGWSVLLALGSLFvGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLv 313
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 15598728 316 AGNQPGIDPVIGVAAVSTVGYGGLLMGPPLIGLLAHEIGLRW 357
Cdd:cd17474 314 TELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSA 355
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
163-357 |
9.56e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.06 E-value: 9.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 163 FLILTALGLLSLPFFVRALLPPDPSKAGARKGGGFTLPPRALLGLGLLILCAFVSEGGVADWSALFLHSVLDASERVAAL 242
Cdd:cd06173 169 LLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGL 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 243 GFAAFSAAMVVGRLFGDRLRGRIDDAPLLRGLGSLATLGMLVALFSPWPALSIAGFGVVGLGLSVMVPIVISAAGNQPGi 322
Cdd:cd06173 249 LLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVP- 327
|
170 180 190
....*....|....*....|....*....|....*..
gi 15598728 323 DPVIG--VAAVSTVGYGGLLMGPPLIGLLAHEIGLRW 357
Cdd:cd06173 328 DELRGrvFSVYNALNSGAMPLGALLAGLLADALGLSA 364
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
233-357 |
1.09e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 40.73 E-value: 1.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 233 LDASERVAALGFAAFSAAMVVGRLFGDRLRGRIDDAPLLRGLGSLATLGMLVALFSPWPALSIAGFGVVGLGLSVMVPIV 312
Cdd:COG2814 40 LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAA 119
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 15598728 313 ISAAGNQ-PGIDPVIGVAAVSTVGYGGLLMGPPLIGLLAHEIGLRW 357
Cdd:COG2814 120 LALIADLvPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
61-301 |
1.28e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 40.72 E-value: 1.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 61 PLSGFLVQRIGSRSVVIGGCLIMLLVFPLLGLSQGWWQLALAFYVLGVSFAGMDVAMNIQAVDVERLLGKPCMSMLHGMY 140
Cdd:cd17355 56 PFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTA 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 141 SLGCLVGALSAAALAGLTPF---WHFLILTALGLLSLPFFVRALLPPDPSKAGARKGGGFTLPPRALLGLGL-------- 209
Cdd:cd17355 136 GGGLGSLVFLPLGAALIEAFgwrTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTLKEALrsasfwll 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 210 ---LILCAFVSEGGVADWSALFLHSVLDASerVAALGFAAFSAAMVVGRLFGDRLRGRIDDAPLLRGLGSLATLGMLVAL 286
Cdd:cd17355 216 alaFFLCGFAVVGLIVHLVPYLADRGISPA--AAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLL 293
|
250
....*....|....*
gi 15598728 287 FSPWPALSIAGFGVV 301
Cdd:cd17355 294 LLPFPPLALLLFAAL 308
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
48-113 |
1.77e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 40.20 E-value: 1.77e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15598728 48 ALLGVGVGALTAF---PLSGFLVQRIGSRSVVIGGCLIMLL----VFPLLGLSQGWWQLALAFYVLGVSFAGM 113
Cdd:cd17369 266 VLLAVLIASVVAAitiPLFGWLSDRVGRRPVYLAGALLAALfafpFFWLLDTGSTWLIVLAAVVVLGVLHGMM 338
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
61-349 |
2.64e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 39.47 E-value: 2.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 61 PLSGFLVQRIGSRSVVIGGCLIMLLVFPLLGLSQGWWQLALAFYVLGVSFAGMDVAMNiqaVDVERLLGKPcMSMLHGMY 140
Cdd:COG2807 71 PLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLP---GLIKRWFPDR-VGLMTGLY 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 141 SLGclvGALSAAALAGLTPF--------WHFLILTALGLLSLPFFVRALLPPDPSKAGARKGGGFTLP---PRALLGLGL 209
Cdd:COG2807 147 TAA---MGLGAALAAGLTVPlaaalgwrGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLwrsPLAWLLTLF 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 210 LILCAFVSEGGVAdWSALFLHSvLDASERVAALGFAAFSAAMVVGRLFGDRLRGRIDD-APLLRGLGSLATLGMLVALFS 288
Cdd:COG2807 224 FGLQSLLYYAVVA-WLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDrRPLLLLLGLLGLAGLLGLLLA 301
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15598728 289 P--WPALSIAGFGVVGLGLSVMVPIVISAAGNQPGIDPVIgVAAVSTVGYGGLLMGPPLIGLL 349
Cdd:COG2807 302 PgsLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAAL-SGMAQSVGYLLAALGPLLVGAL 363
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
10-143 |
3.98e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 39.12 E-value: 3.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 10 RLACIYFFAMAGLVIGNLMGrIPALKEQTQLDERALGQALLGVGVGALTAFPLSGFLVQRIGSRSVVIGGCLIMLLVFPL 89
Cdd:COG2211 232 LLLLAYLLFFLALALVAALL-LYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL 310
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 90 LGLSQG--WWQLALAFYVLGVSFAGMDVAMNIQAVDV----ERLLGKPCMSMLHGMYSLG 143
Cdd:COG2211 311 LFFLGPgnLWLLLVLAALAGIGLGAILVLPWAMLADVvdydEWKTGRRREGLYFGIFTFA 370
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
50-349 |
4.69e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 38.71 E-value: 4.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 50 LGVGVGALTAFPLsGFLVQRIGSRSVVIGGCLIMLLVFPLLGLSQGWWQLALAFYVLGVSFAGMDVAM--NIQAVDVERL 127
Cdd:COG2223 48 IPVLVGALLRIPL-GFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGiaLVSKWFPPDR 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 128 LGKPcMSMLHGMYSLGCLVGALSAAALAGL----TPFWHFLILTALGLLSLPFFVRALLPPDPSKAGARKGGGF-TLPPR 202
Cdd:COG2223 127 RGLA-LGLAAGGGNLGAAVAAFLAPLLIAAfgwrNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLeALRDP 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598728 203 ALLGLGLLILCAFVSEGGVADWSALFLHSVLDASERVAALGFAAFSAAMVVGRLFGDRLRGRIDDAPLLRGLGSLATLGM 282
Cdd:COG2223 206 RFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGL 285
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15598728 283 LVALFSPWP-ALSIAGFGVVGLGLSVMVPIVISAAGNQ-PGIDPVIGVAAVSTVGYGGLLMGPPLIGLL 349
Cdd:COG2223 286 LLLALALGSlWLFLVLFLLLGLALGGGNGAVFALVPDIfPTKNAGAVYGLVGAAGGLGGFLGPLLFGAL 354
|
|
| |
