|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
23-425 |
5.02e-91 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 279.46 E-value: 5.02e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 23 TWRLMPLLLVCYVFAHLDRINIGFAKLQMSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACLMLVWGC 102
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 103 LSTAMLLVETARGFYLLRFLLGVAEAGFFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFhdalgl 182
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLF------ 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 183 rGWQWMFLIEGLPVVLLGVVVWCSLpesfervtwlsdeqkhllreelageeqrktitsfsgifsnPQVWLLVAIYFAVML 262
Cdd:cd17319 155 -GWRWAFIIEGLLGLLLAVLWWFYL----------------------------------------RQVWGLALGYFGINY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 263 AVNTIAFWMPSLIHGAGIAQDSRIGMLSAVPYLAGCAFMIFIGRSSDRL--RERRWHLGIPLLMAAAGLSLAALApTSAW 340
Cdd:cd17319 194 ALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrGARRLVIIIGLLLAAVGLLLAYLT-TSPV 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 341 LVMGGLVIAGMGASAALPMFWQLPPAFLSSATLAAGIALISSFGSIAAFLAPYLIGWMRDTTQSASLALYLLAILIALGA 420
Cdd:cd17319 273 VAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAA 352
|
....*
gi 15599321 421 GLVLR 425
Cdd:cd17319 353 LLVLL 357
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
32-402 |
1.72e-66 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 217.59 E-value: 1.72e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 32 VCYVFAHLDRINIGFAKLQMSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACLMLVWGCLSTAMLLVE 111
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 112 TARGFYLLRFLLGVAEAGFFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFHdalglrgWQWMFLI 191
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFS-------WQWAFII 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 192 EGLPVVLLGVVVWCSLPESFERVTWLSDEQKHLLREELAGEEQRKTITSFSG-----IFSNPQVWLLVAIYFAVMLAVNT 266
Cdd:TIGR00893 154 EGVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGPSTPKKyqikeLLKDRRVWGLALGQFLVNIGLGF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 267 IAFWMPSLIHGAGIAQDSRIGMLSAVPYLAGCAFMIFIGRSSDRLRERRWHLGIPLLMAAAGLSLAALAP------TSAW 340
Cdd:TIGR00893 234 FLTWFPTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLVLSLLMfatnyvNIPY 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15599321 341 LVMGGLVIAGMGASAALPMfWQLPPAFLSSATLAAGIALISSFGSIAAFLAPYLIGWMRDTT 402
Cdd:TIGR00893 314 AALALVALGFFGLGAGAIG-WALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATT 374
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
16-402 |
1.35e-56 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 190.47 E-value: 1.35e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 16 DSTHDRVTWRLMPLLLVCYVFAHLDRINIGFAKLQMSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIAC 95
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 96 LMLVWGCLSTAMLLVETARGFYLLRFLLGVAEAGFFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEG 175
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 176 FhdalglrGWQWMFLIEGLpvvllgvvvwcslpesfervtwlsdeqkhllreelageeqrktitsFSGIFSNPQVWLLVA 255
Cdd:COG2271 161 F-------GWRAAFLILGL----------------------------------------------PGLLLALLRFWLLAL 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 256 IYFAVMLAVNTIAFWMPSLIHGAGIAQDSRIGMLSAVPYLAGCAFMIFIGRSSDRLRERRWHLGIPLLMAAAGLSLAALA 335
Cdd:COG2271 188 AYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLAL 267
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15599321 336 PTSAWLVMGGLVIAGMGASAALPMFWQLPPAFLSSATLAAGIALISSFGSIAAFLAPYLIGWMRDTT 402
Cdd:COG2271 268 LPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT 334
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
24-394 |
8.90e-47 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 165.88 E-value: 8.90e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 24 WRLMPLLLVCYVFAHLDRINIGFAKLQ-MSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACLMLVWGC 102
Cdd:cd17327 4 LFILPLLCILYFLQYLDKSNISNAAVMgMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 103 LSTAMLLVETARGFYLLRFLLGVAEAGFFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEgFHDALGL 182
Cdd:cd17327 84 LTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFK-ILGVGGL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 183 RGWQWMFLIEGLPVVLLGVVVWCSLPESFERVTWLSDEQKHLLREELA-----GEEQRKTITSFSGIFSNPQVWLLVAIY 257
Cdd:cd17327 163 AGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRanqtgKGDQKFKWKQIKEAFKDPRTWLLFLFF 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 258 FAVMLAVNTIAFWMPsLIHGAGIAQDSRIGMLSAVPYLAGCAFMIFIGRSSDRLRERRWHLGIPLLMAAAGLSLAALAPT 337
Cdd:cd17327 243 FCSQITNNGISNFLP-LILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLALVGSIILLAAPN 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 15599321 338 SAWLVMGGLvIAGMGASAALPMFWQLPPAFLSSAT-LAAGIALISSFGSIAAFLAPYL 394
Cdd:cd17327 322 PPGAYFAAY-ILGGGSYAGFPILLSWISSNCAGYTkRATVLAIMLIFYNVGNIVAPQI 378
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
24-402 |
7.35e-42 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 152.34 E-value: 7.35e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 24 WRLMPLLLVCYVFAHLDRINIGFAKLQMSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACLMLVWGCL 103
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 104 STAMLLVETARGFYLLRFLLGVAEAGFFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFhdalglr 183
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF------- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 184 GWQWMFLIEGLPVVLLGVVVWCSLPESfervtwlsdeqkhllrEELAGEEQRKTITSFSGIFSNPQVWLLVAIYFAVMLA 263
Cdd:COG2223 157 GWRNAFLILGILLLVVAVLAWLFLRDP----------------PAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGS 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 264 VNTIAFWMPSLIHGAGIAQDSRIGMLSAVPYLAGCAFMIFIGRSSDRLRERRWHLGIpLLMAAAGLSLAALAPTSAWLVM 343
Cdd:COG2223 221 FIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIV-FALMALGLLLLALALGSLWLFL 299
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 15599321 344 GGLVIAGMGASAALPMFWQLPPAFLSSATLAAGIALISSFGSIAAFLAPYLIGWMRDTT 402
Cdd:COG2223 300 VLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAT 358
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
30-392 |
4.17e-30 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 119.06 E-value: 4.17e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 30 LLVCYVFAHLDRINIGFA-KLQMSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACLMLVWGCLSTAML 108
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 109 LVETARGFYLLRFLLGVAEAGFFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFhdalglrGWQWM 188
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF-------GWRAA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 189 FLIEGLPVVLLGVvvwcslpesferVTWLSDEQKHLLREELAGEEQRKTITSFSGIFSNPQVWLLVAIyFAVMLAVNTIA 268
Cdd:pfam07690 154 FLILAILSLLAAV------------LLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 269 FWMPSLIHGAGIAQdSRIGMLSAVPYLAGCAFMIFIGRSSDRL-RERRWHLGIPLLMAAAGLSLAALAPTSAWLVMGGLV 347
Cdd:pfam07690 221 TYLPLYQEVLGLSA-LLAGLLLGLGGLLGAIGRLLLGRLSDRLgRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALL 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 15599321 348 IAGMGASAALPMFWQLPPAFLSSATLAAGIALISSFGSIAAFLAP 392
Cdd:pfam07690 300 LLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
17-391 |
5.01e-28 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 113.53 E-value: 5.01e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 17 STHDRVTWRLMPLLLVCYVFAHLDRINIGFAKLQMSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACL 96
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 97 MLVWGCLSTAMLLVETARGFYLLRFLLGVAEAGFFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGF 176
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 177 hdalglrGWQWMFLIEGLPVVLLGVVVWCSLPESfervtwlsdeqkhllreelAGEEQRKTITSFSGIFSNPQVWLLVAI 256
Cdd:COG2814 162 -------GWRWVFLVNAVLALLALLLLLRLLPES-------------------RPAARARLRGSLRELLRRPRLLLLLLL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 257 YFAVMLAVNTIAFWMPSLIHGAGIAQDSRIGMLSAVPYLAGCAFMIFIGRSSDRLRERRwhLGIPLLMAAAGLSLAALAP 336
Cdd:COG2814 216 AFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRR--LLLIGLLLLALGLLLLALA 293
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 15599321 337 TSAWLVMGGLVIAGMGASAALPMFWQLPPAFLSSATLAAGIALISSFGSIAAFLA 391
Cdd:COG2814 294 GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
30-402 |
5.69e-25 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 105.59 E-value: 5.69e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 30 LLVCYVFAHLDRINIGFAKLQMSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACLMLVWGCLSTAMLL 109
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 110 VETARGFYLLRFLLGVAEAGFFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFHDalglrGWQWMF 189
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGF-----GWRAVF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 190 LIEGLPVVLLGVVVWCSLPesfervtwlsdEQKHLLREELAGEEQRKTITSFSGIFSNPQVWLLVAIYFAVMLAVNTIAF 269
Cdd:cd06174 156 LIAAALALLAAILLLLVVP-----------DPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFST 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 270 WMPSLIHGAGIAQDSRIGMLSAVPYLAGCAFMIFIGRSSDRLRERRWHLGIpLLMAAAGLSLAALAPTSAWLVMGGLVIA 349
Cdd:cd06174 225 LLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLI-GLLLMALGLALLLLAPSLLLLLLLLLLL 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 15599321 350 GMGASAALPMFWQLPPAFLSSATLAAGIALISSFGSIAAFLAPYLIGWMRDTT 402
Cdd:cd06174 304 GFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAT 356
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
50-402 |
5.66e-22 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 97.25 E-value: 5.66e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 50 QMSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACLMLVWGCLSTAMLLVETARGFYLLRFLLGVAEAG 129
Cdd:COG2807 43 EIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAV 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 130 FFPGILVYLNRWFPaRRRGQITALFAIAVPMAGVIGGPLSGWILEGFhdalglrGWQWMFLieglpvvllgvvvWCSLPE 209
Cdd:COG2807 123 GNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAAL-------GWRGALA-------------VWALLA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 210 SFERVTWLSdeqkhLLREELAGEEQRKTITSFSGIFSNPQVWLLVAIYFAVMLAVNTIAFWMPSLIHGAGIAqDSRIGML 289
Cdd:COG2807 182 LLALLLWLP-----LLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLS-AATAGLL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 290 SAVPYLAGCAFMIFIGRSSDRLRERRWHLGIPLLMAAAGLSLAALAPTSAWLVmgGLVIAGMGASAALPMFWQLPPAFL- 368
Cdd:COG2807 256 LSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWL--WAVLLGLGQGGLFPLALTLIGLRAr 333
|
330 340 350
....*....|....*....|....*....|....
gi 15599321 369 SSATLAAGIALISSFGSIAAFLAPYLIGWMRDTT 402
Cdd:COG2807 334 TPAEAAALSGMAQSVGYLLAALGPLLVGALHDAT 367
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
21-398 |
1.37e-17 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 83.95 E-value: 1.37e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 21 RVTWRLMPLLLVCYVFAHLDRINIGFAKLQMSADLHFSDTVYG--LGAGLFFIAY-ALFGLPsnlMLERIGPRRWIACLM 97
Cdd:TIGR00895 13 RYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGflFSAGLIGMAFgALFFGP---LADRIGRRRVLLWSI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 98 LVWGCLSTAMLLVETARGFYLLRFLLGVAEAGFFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFh 177
Cdd:TIGR00895 90 LLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVF- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 178 dalglrGWQWMFLIEGLPVVLLGVVVWCSLPES------------FERVTWLSDEQKHLLREELAGEEQRKTI--TSFSG 243
Cdd:TIGR00895 169 ------GWRSLFYVGGIAPLLLLLLLMRFLPESidflvskrpetvRRIVNAIAPQMQAEAQSALPEQKSTQGTkrSVFKA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 244 IFS---NPQVWLLVAIYFAVMLAVNTIAFWMPSLIHGAGiAQDSRIGMLSAVPYLAGCAFMIFIGRSSDRLRERrwHLGI 320
Cdd:TIGR00895 243 LFQgktARITVLLWLLYFMLLVGVYFLTNWLPKLMVELG-FSLSLAATGGALFNFGGVIGSIIFGWLADRLGPR--VTAL 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15599321 321 PLLMAAAGLSLAALAPTSAWLVMGGLVIAGMGASAALPMFWQLPPAFLSSATLAAGIALISSFGSIAAFLAPYLIGWM 398
Cdd:TIGR00895 320 LLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYL 397
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
53-401 |
1.33e-16 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 80.70 E-value: 1.33e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 53 ADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACLMLVWGCLSTAMLLVETARGFYLLRFLLGVAEAGFFP 132
Cdd:cd17325 24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 133 GILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEgfhdalgLRGWQWMFLIEGLPVVLLGVVVWCSLPESFE 212
Cdd:cd17325 104 AAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAD-------ALGYRAPFLVCAALALLALVLALLLLPEPRP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 213 RvtwlsdeqkhllrEELAGEEQRKTITSFSGIFSNPQVWLLVAIYFAVMLAVNTIAFWMPSLIHGAGIAQDSRIGMLSAV 292
Cdd:cd17325 177 P-------------PNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 293 PYLAGCAFMIFIGRSSDRLreRRWHLGIPLLMAAAGLSLAALAPTSAWLVMGGLVIAGMGASAALPMFWQLPPAFLSSAT 372
Cdd:cd17325 244 QGLASALSQPPAGKLSDRI--GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEG 321
|
330 340
....*....|....*....|....*....
gi 15599321 373 LAAGIALISSFGSIAAFLAPYLIGWMRDT 401
Cdd:cd17325 322 RGTAMGLFNTAFSLGMVLGPLLGGFLYDA 350
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
50-387 |
2.89e-16 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 79.90 E-value: 2.89e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 50 QMSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACLMLVwgcLSTAMLLVETARGFYLL---RFLLGVA 126
Cdd:cd17324 24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLL---FILGNLLAALAPSFALLllaRALAGLA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 127 EAGFFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFhdalglrGWQWMFLIEGLPVVLLGVVVWCS 206
Cdd:cd17324 101 HGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL-------GWRAAFLAIAVLALLAALLLWRL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 207 LPesfervtwlsdeqkhllREELAGEEQRKTITSFSGIFSNPQVWLLVAIYFAVMLAVNTIAFWMPSLIHGAGIAQDSRI 286
Cdd:cd17324 174 LP-----------------SLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 287 GMLSAVPYLAGCAFMIFIGRSSDRLRERRwhLGIPLLMAAAGLSLAALAPTSAWLVMGGLVIAGMGASAALPMFW----Q 362
Cdd:cd17324 237 IGLLLLFGVAGVVGSPLAGRLADRGGRRA--LLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQtrvlR 314
|
330 340 350
....*....|....*....|....*....|.
gi 15599321 363 LPPAF------LSSATLAAGIALISSFGSIA 387
Cdd:cd17324 315 LAPEArglassLYLAAYNLGGALGAALGGLV 345
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
28-400 |
8.91e-15 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 75.74 E-value: 8.91e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 28 PLLLVCYVFAHLDRINIGFAKLQMSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACLMLVWgclSTAM 107
Cdd:cd17328 2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIW---SAAT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 108 LLVETARGFYLL---RFLLGVAEAGFFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWIlegfhdALGLRG 184
Cdd:cd17328 79 LLSSFAPNFWQLllfRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLV------AQATGG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 185 WQWMFLIEGLPVVLLGVVVWCSLPESfervtwlsdEQKHLLREELAGEEQRKTITSFSGIFSNPQVWLLVAIYFAVMLAV 264
Cdd:cd17328 153 WRWAFRVTGVLGVLLAILLLLFVREP---------PRGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVT 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 265 NTIAFWMPSLI---HGAGIAQDSRIGM-LSAVPYLAGCAFMIFIGRSSDRLRER--RWHLGIPLLMAAAGLSLAALAPTS 338
Cdd:cd17328 224 GALAFWAPTFFlraFGVGDLSSADVGLiFGAITCIAGVLGVLLGGILADRLRRKtpRADPLVCAVGLLAAAPFLFLALVL 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15599321 339 AWLVMGGLVIAGMGASAALPMFWQL---------PPAFLSSAtLAAGIALISSFGSiaaFLAPYLIGWMRD 400
Cdd:cd17328 304 ALSNLLLAWVLLFLGEFLLSLNWAPvfaillyvvIPTRRSTA-SAIQILLSHLLGD---AGSPYLIGLISD 370
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
15-305 |
3.76e-12 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 66.76 E-value: 3.76e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 15 SDSTHDRVTWRLMPLLLVCYVFAHLDRINIGFAKLQMSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIA 94
Cdd:COG0477 4 TDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 95 CLMLVWGCLSTAMLLVETARGFYLLRFLLGVAEAGFFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILE 174
Cdd:COG0477 84 IGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 175 GFhdalglrGWQWMFLIEGLPVVLLGVVVWCSLPESFERVTWLSDEQKHLLREELAGEEQRKTITSFSGIFSNPQVWLLV 254
Cdd:COG0477 164 AL-------GWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAG 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 15599321 255 AIYFAVMLAVNTIAFWMPSLIHGAGIAQDSRIGMLSAVPYLAGCAFMIFIG 305
Cdd:COG0477 237 AALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLL 287
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
50-402 |
6.30e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 66.80 E-value: 6.30e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 50 QMSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACLMLVWGCLSTAMLLVETARGFYLLRFLLGVAEAG 129
Cdd:COG0738 33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 130 FFPGILVYLNRWFPARRRgQITALFAIAVPMAGVIGGPLSGWILEGFHDAlglrGWQWMFLIEGLPVVLLGVVVWCS-LP 208
Cdd:COG0738 113 LDVAANPYVAALGPETAA-SRLNLLHAFFSLGALLGPLLGGLLILLGLSL----SWHLPYLILAVLLLLLALLFLRSkLP 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 209 ESfervtwlsdeqkhllreELAGEEQRKTITSFSGIFSNPQVWLLVAIYFAVMLAVNTIAFWMPSLIHGAGIAQDSRIGM 288
Cdd:COG0738 188 EI-----------------EEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAAL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 289 LSAVPYLAGCAFMIFIGRSSDRLRERRWHLGipLLMAAAGLSLAALAPTSAWLVMGGLVIAGMGASAALPMFWQLPPAFL 368
Cdd:COG0738 251 GLSLFWGGMTIGRFLGGFLLKRFGPVRLLRL--SALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGL 328
|
330 340 350
....*....|....*....|....*....|....
gi 15599321 369 SSATlAAGIALISSFGSIAAFLAPYLIGWMRDTT 402
Cdd:COG0738 329 GKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAF 361
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
54-360 |
1.44e-11 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 65.69 E-value: 1.44e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 54 DLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACLMLVWGCLSTAMLLVETARGFYLLRFLLGVAEAGFFPG 133
Cdd:cd17489 25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 134 ILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFhdalglrGWQWMFLIEGLPVVLLGVVVWcslpesfer 213
Cdd:cd17489 105 AATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHL-------GFAVLFIVAAVLALLALLLVF--------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 214 vtwlsdeqkHLLREELAGEEQRKTITSFSGIFSNPQVWLLVAIYFAVMLAVNTIAFWMPSLIHGAGIAQdsrIGMLSAVP 293
Cdd:cd17489 169 ---------LVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISN---AGLFFTVY 236
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15599321 294 YLAGCAFMIFIGRSSDRLRERRwhLGIPLLMAAAGLSLAALAPTSAWLVMGGLVIAGMGASAALPMF 360
Cdd:cd17489 237 AIALLLSRPFSGKLSDRKGPKT--VIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPAL 301
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
30-398 |
5.00e-11 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 63.76 E-value: 5.00e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 30 LLVCYVFAHLDRINI---GFAKLQMSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACLMLVWGCLSTA 106
Cdd:cd17365 1 LALCFLIIVLDGFDLavmGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 107 MLLVETARGFYLLRFLLGVAEAGFFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFhdalglrGWQ 186
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAF-------GWR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 187 WMFLIEGLPVVLLGVVVWCSLpesfervtwlsdeqkhllreelageeqrktitsfsgifsnpqvwLLVAIYFAVMLAVNT 266
Cdd:cd17365 154 SVFLLGGVPPLILLPLLRGTL--------------------------------------------LLWVTFFMGLLLVYL 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 267 IAFWMPSLIHGAGIAQdSRIGMLSAVPYLAGCAFMIFIGRSSDRLReRRWHLGIPLLMAAAGLSLAALAPTSAWLVMGGL 346
Cdd:cd17365 190 LNSWLPKLMVEAGYSL-SQALTITLLLNIGGVIGSLLLGWLADRFG-PKRVLALFFALGAVSLALLGVSPASLVLLYVLV 267
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 15599321 347 VIAGMGASAALPMFWQLPPAFLSSATLAAGIALISSFGSIAAFLAPYLIGWM 398
Cdd:cd17365 268 FLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLL 319
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
23-402 |
7.15e-11 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 63.45 E-value: 7.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 23 TWRLMPLLLVCYVFAHLDRINIGFAKLQMSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACLMLVWGC 102
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 103 LSTAMLLVETARGFYLLRFLLGVAEAGFFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFhdalgl 182
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYY------ 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 183 rGWQWMFLIEGLPVVLLGVVVWcslpesfervTWLSDeqkhllreelageeqrktitsfsgifSNPQVWLLVAIYFAVML 262
Cdd:cd17312 155 -GWRAAFLVPGIVGLVVAIILF----------FFLRD--------------------------SPPYVWVLSLAYAFVYI 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 263 AVNTIAFWMPS-LIHGAGIAQDSRIGMLSAVPyLAGCAFMIFIGRSSDRLRERRWHLG--IPLLMAAAGLSLAALAPTSA 339
Cdd:cd17312 198 VRYACLDWGPLyLYEVKGYSLIDAGWFSSLYE-VGGIAGTILAGLLSDKLFGGRRAPIavIYMLLMTLSLALFWFFPHNK 276
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15599321 340 WLVMGGLVIAGMGASAALPMFWQLPPAFL-SSATLAAGIALISSFGSIAAFLAPYLIGWMRDTT 402
Cdd:cd17312 277 LLSIVLLFLIGFFVGGPINLIGGAAAQDIgRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHY 340
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
27-318 |
7.64e-11 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 63.34 E-value: 7.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 27 MPLLLVCYVFAHLDRINIGFAKLQMSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACLMLVWGcLSTA 106
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWS-LATL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 107 MLLVETARGFYLL---RFLLGVAEAGFFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFhdalglr 183
Cdd:cd17380 80 LTPLLAYSSLPLLilsRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYY------- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 184 GWQWMFLIEglpvvLLGVVVWCslpesferVTWLsdeqkhllreelageeqrktitsfsgiFSNPQVWLLVAIYFAVMLA 263
Cdd:cd17380 153 GWPSVFYFF-----GLLGLLWA--------LVWL---------------------------IYLPPVWAIIVAHFCMNWG 192
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 15599321 264 VNTIAFWMPSLIHgAGIAQDSRIGMLSAVPYLAGCAFMIFIGRSSDRLRERRWHL 318
Cdd:cd17380 193 FYILLSWLPTYFH-EVLVPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTV 246
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
74-402 |
9.24e-11 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 62.98 E-value: 9.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 74 ALFGLPSNLMLERIGPRRWIACLMLVWGCLSTAMLLVETargFYLL---RFLLGVAEAGFFPGILVYLNRWFPARRRGQI 150
Cdd:cd17473 49 ALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDS---LYALlasRALLGIGVAGIMTLATALIGDYFEGEERAKM 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 151 TALFAIAVPMAGVIGGPLSGWilegfhdaLGLRGWQWMFLIEGLPVVLLGVVVWCsLPESfervtwlsdeqkhllreELA 230
Cdd:cd17473 126 LGLQSAAMSLGGVVFLLLGGA--------LAEIGWRAPFLVYLLALPVLILVLLF-LPEP-----------------ARK 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 231 GEEQRKTITSFSGIFSNPQVWLLVAIYFAVMLAVNTIAFWMPSLIHGAGIAQDSRIGMLSAVPYLAGcafmIFIGRSSDR 310
Cdd:cd17473 180 SKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAG----AIGALLFGR 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 311 LRERRWHLGIPLLMAAAGLSLAALAPTSA--WLVMGGLVIAGMGASAALPMFWQLPPAFLSSATLAAGIALISSFGSIAA 388
Cdd:cd17473 256 LKRRLGKRRLLAIGFALMALGFLLLALASglWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQ 335
|
330
....*....|....
gi 15599321 389 FLAPYLIGWMRDTT 402
Cdd:cd17473 336 FLSPLVLGPLVNLT 349
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
51-402 |
1.16e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 62.64 E-value: 1.16e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 51 MSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACLMLVWGCLSTAMLLVETARGFYLLRFLLGVAEAGF 130
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 131 FPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFhdalglrGWQWMFLIEGLPVVLLGVVVWCSLPES 210
Cdd:cd17475 102 QPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHY-------GWRAAFVVAGLVSILAAVLFWLFYREP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 211 fervtwlsdeqkhlLREELAGEEQRKTITSFSGIFSNPQVWLLVAIYFAVMLA-VNTIAFWMPSLI--HGAGIAQdsrIG 287
Cdd:cd17475 175 --------------PAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPqFALLTFLLLFLHdhLGLSVVA---AG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 288 MLSAVPYLAGCAFMIFIGRSSDRLRERR------WHLGIPLLMAAAGLSLAALAPtsAWLVMGGLVIAGMGASAalpmfW 361
Cdd:cd17475 238 ALLAVAQLGGALGRIGLGRVSDRVFGGRrrpvlvITAAIAAAALLVLSLLSPGTP--LWLLVLLLILLGLFAIG-----W 310
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 15599321 362 QlPPAFLSSATLA----AGIALISS--FGSIAAFLAPYLIGWMRDTT 402
Cdd:cd17475 311 N-GLYLTLVAESAgpeqAGTALGLAntINFIGIAIGPPLFGLLVDAT 356
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
34-398 |
2.19e-10 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 61.85 E-value: 2.19e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 34 YVFAHLDRINIGFAKLQMSADLHFSDTVYGLGA--GLFFIAYALFGLPSNLMLERIGPRRWIACLMLVWGCLSTAMLLVE 111
Cdd:cd17316 8 WFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLlfAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLP 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 112 TARGFYLLRFLLGVAEAGFFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFHDALGlrgWQWMFLI 191
Cdd:cd17316 88 TPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWG---WRILFLI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 192 EGlpvvllgvvvwcslpesfervtwlsdeqkhllreelageeqrktITSFSGIFSNPQVWLLVAIYFAVMLAVNTIAFWM 271
Cdd:cd17316 165 GA--------------------------------------------LPALLALLLRRRTLLLILLWFFISFGYYGLTTFL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 272 PSLIHGAGIAQDSRIGMLSAVPYLAGCAFMIFIGRSSDRLRERRWHLGIPLLMAAAGLSLAALAPTSAWLVMGGLVIAGM 351
Cdd:cd17316 201 PTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSF 280
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 15599321 352 GASAALPMFWQLPPAFLSSATLAAGIALISSFGSIAAFLAPYLIGWM 398
Cdd:cd17316 281 FVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALL 327
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
69-316 |
5.10e-09 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 57.63 E-value: 5.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 69 FFIAYALFGLPSNLMLERIGPRRwiaclMLVWGCLSTAMLLVET---ARGFY----LLRFLLGVAEAGFFPGILVYLNRW 141
Cdd:cd17318 65 FFYGYILTQIPGGYLAEKYGAKR-----VLGYSILITALLTLLTplaARGGYgaliVLRILQGLAQGVTFPAMHALWAKW 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 142 FPARRRGQitaLFAIAvpMAG-----VIGGPLSGWILEGFhdalglrGWQWMFLIeglpvVLLGVVVWCslpesferVTW 216
Cdd:cd17318 140 APPLERSR---LTSIA--YSGsqfgtVIAMPLSGFLCESL-------GWPSIFYI-----FGGLGLLWC--------LLW 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 217 lsdeqkhllreelageeqrktitsfsgIFSNPQVWLLVAIYFAVMLAVNTIAFWMPSLIHGAGIAQDSRIGMLSAVPYLA 296
Cdd:cd17318 195 ---------------------------FFLVLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLA 247
|
250 260
....*....|....*....|
gi 15599321 297 GCAFMIFIGRSSDRLRERRW 316
Cdd:cd17318 248 MWICSIVGGYLADWLRSRGI 267
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
51-400 |
2.55e-08 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 55.74 E-value: 2.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 51 MSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACLMLVWGCLSTAMLLVETARGFYLLRFLLGVAEAG- 129
Cdd:cd17355 29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGt 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 130 FFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFhdalglrGWQWMFLIEGLPVVLLGVVVWcslpe 209
Cdd:cd17355 109 LAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAF-------GWRTALLVLALLALLVLVPVL----- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 210 sfervTWLSDEQKHLLREELAGEEQRKTITSFSGIFSNPQVWLLVAIYFAVMLAVNTIAFWMPSLIHGAGIAQDSRIGML 289
Cdd:cd17355 177 -----LLLRRRPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVAL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 290 SAVpYLAGCAFMIFIGRSSDRLrERRWHLGIPLLMAAAGLSLAALAPTSAWLVMGGLVIAGMGASAALPMFWQLPPAFLS 369
Cdd:cd17355 252 ALI-GLFNIVGRLLSGWLGDRY-SPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFG 329
|
330 340 350
....*....|....*....|....*....|.
gi 15599321 370 SATLAAGIALISSFGSIAAFLAPYLIGWMRD 400
Cdd:cd17355 330 ARSYGTLFGLVFAPHQLGSALGPWLGGLLYD 360
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
49-402 |
8.31e-08 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 53.79 E-value: 8.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 49 LQMSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRW-IACLMLVWGCLSTAMLLVETARGFYLLRFLLGVAE 127
Cdd:cd17341 23 PVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVfIASLLLLLIPLLALALAVSSYWGLLVLGFLLGFAG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 128 AGFFPGIlVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFHDALGLRGWQWMFLIEGLPVVLLGVVVWcsl 207
Cdd:cd17341 103 ANFASGQ-PWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVFDGGFVGWRNAFFVPGILLAIAAVLVL--- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 208 pesfervTWLSDeqkhllrEELAGEEQRKTITSFSGIFSNPQVWLLVAIYFAVMLAVNTIAFWMPSLIHgagiaQDSRIG 287
Cdd:cd17341 179 -------LFGDD-------LPTGKASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFK-----TRFGLP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 288 MLSAVPYLAGCAFMIFIGRS-----SDRLRERRWHLGIPLLMAAAGLSLAALAPTSAWLVMGGL---VIAGMGASAALPM 359
Cdd:cd17341 240 LVTAGILAALFPLAGALARPaggwlSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLalfVALGLGAGAGNGS 319
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 15599321 360 FWQLPPaFLSSATLAAGIALISSFGSIAAFLAPYLIGWMRDTT 402
Cdd:cd17341 320 VFRMVP-FIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMT 361
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
34-400 |
2.97e-07 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 52.38 E-value: 2.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 34 YVFAHLDRINIGFAKLQMSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACLMLVWGCLSTAMLLVETA 113
Cdd:TIGR00881 4 YAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 114 RGFYLLRFLLGVAEAGFFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFHDalglrgWQWMFLIEG 193
Cdd:TIGR00881 84 WVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYS------WHWVFIVPG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 194 LPVVLLGVVVW---------CSLPESFErvtWLSDEQKHLLREELAgEEQRKTITsFSGIFSNPQVWLLVAIYFAVMLAV 264
Cdd:TIGR00881 158 IIAIIVSLICFlllrdspqsCGLPPAEE---MPNEEPDGDAEKKEE-ELTKKQIF-LQYVLLNKVLWYISLGYVFVYVVR 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 265 NTIAFWMPS-LIHGAGIAQDSRIGMLSaVPYLAGCAFMIFIGRSSDRLRERRWH--------------LGIPLLMAAAGL 329
Cdd:TIGR00881 233 TGILDWSPLyLTQEKGFSKEKASWAFT-LYELGGLVGTLLAGWLSDKLFNGRRGplavffmaliivslLVYWLNPAANPL 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15599321 330 SLAALAPTSAWLVMGGLVIAGMGASAALPMFwqlppaflsSATLAAGIalISSFGSIAAFLAPYLIGWMRD 400
Cdd:TIGR00881 312 MDLICLFALGFLVYGPQMLIGVIASELAPKK---------AAGTAAGF--VGFFAYLGGILAGLPLGYLAD 371
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
51-191 |
3.95e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 51.79 E-value: 3.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 51 MSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRwiaCLMLVWGCLSTAMLLVETARGFYLL---RFLLGVAE 127
Cdd:cd17321 22 IARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKR---VFLIGLALFGLASLLCALAPSLAFLiaaRALQGIGA 98
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15599321 128 AGFFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFhdalglrGWQWMFLI 191
Cdd:cd17321 99 AAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELF-------GWRWIFLI 155
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
67-210 |
3.04e-06 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 46.49 E-value: 3.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 67 GLFFIAYAL----FGLPSNLMLERIGPRRWIACLMLVWGCLSTAMLLVETARGFYLLRFLLGVAEAGFFPGILVYLNRWF 142
Cdd:TIGR00880 1 GLLLAGYALgqliYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15599321 143 PARRRGQITALFAIAVPMAGVIGGPLSGWILEGFhdalglrGWQWMFLIEGLPVVLLGVVVWCSLPES 210
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFL-------GWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
53-172 |
1.33e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 46.78 E-value: 1.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 53 ADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACLMLVWGCLSTAMLLVETARGFYLLRFLLGVAEAGFFP 132
Cdd:cd17477 24 EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFV 103
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 15599321 133 GILVYLNRWFPARRRGQITALFAIAVpMAGVIGGPLSGWI 172
Cdd:cd17477 104 VSESWLNALATNENRGRVLGLYSTVL-GLGFALGPLLLAL 142
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
55-177 |
1.34e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.20 E-value: 1.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 55 LHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACLMLVWGCLSTAMLLV--ETARGFYLLRFLLGVAEAGFF- 131
Cdd:COG2211 259 LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILv 338
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 15599321 132 ------PGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFH 177
Cdd:COG2211 339 lpwamlADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
147-398 |
2.77e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.05 E-value: 2.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 147 RGQITAlFAIAVPMAGVIGGPLSGWILEGFHDALGLRGWQWMFLIegLPVVLLGVVVWCSLpesfervtwlsdeqkhLLR 226
Cdd:COG2211 145 RTRLSS-WRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALI--FAVLGLLAFLLTFF----------------GTK 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 227 EELAGEEQRKTIT-SFSGIFSNPQVWLLVAIYFAVMLAVNTIAFWMPSLIHGAGIAQDSRIGMLSAVPYLAGCAFMIFIG 305
Cdd:COG2211 206 ERPVPEEEKVSLKeSLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWP 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 306 RSSDRLRERRWHLGIPLLMAAAGLSLAALAPTSAWLVMGGLVIAGMGASAALPMFWQL-----PPAFLSSATLAAGI--A 378
Cdd:COG2211 286 RLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMladvvDYDEWKTGRRREGLyfG 365
|
250 260
....*....|....*....|
gi 15599321 379 LISSFGSIAAFLAPYLIGWM 398
Cdd:COG2211 366 IFTFAIKLGQALAGALAGLL 385
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
51-191 |
3.51e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 45.64 E-value: 3.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 51 MSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACLMLVWGCLSTAMLLVETARGFYLLRFLLGVAEAGF 130
Cdd:cd17325 226 AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLV 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15599321 131 FPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFhdalglrGWQWMFLI 191
Cdd:cd17325 306 FPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF-------GFATPFLA 359
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
32-350 |
3.82e-05 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 45.70 E-value: 3.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 32 VCYVFAHLDRINIGFAKLQMSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACLMLVWGCLSTAMLLVE 111
Cdd:cd17345 10 IGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVP 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 112 TARGFYLLRFLLGVAEaGFFPGILV-----YLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFhdalGLRGWQ 186
Cdd:cd17345 90 SATSSVGLMFILLFLN-GWFQGMGWppsgrTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIF----GDGWWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 187 WMFLIEGLPVVLLGVVVWCSLPESFERVTWLS-DEQKHLLREELAGEEQRKTITS----FSGIFSNPQVWLLVAIYFAVM 261
Cdd:cd17345 165 GAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPiEEYKGDYPEEADGEEEEQELSAweifVKYVLKNKLLWYIAIANVFVY 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 262 LAVNTIAFWMP---SLIHGAGIAQdsrIGMLSAVPYLAGCAFMIFIGRSSDRL-RERRWHLGIPLLMAAAGLSLAALAPT 337
Cdd:cd17345 245 LVRYGILDWAPtylSEVKGFSKAQ---AMWAFSLFEWAAIPGTLLAGWLSDKLfKGRRAPTGIIFMILVIVALIVYWLAP 321
|
330
....*....|...
gi 15599321 338 SAWLVMGGLVIAG 350
Cdd:cd17345 322 NVLVDLIALIALG 334
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
50-398 |
5.70e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 44.87 E-value: 5.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 50 QMSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACLMLVWGCLSTAMLLVETARGFYLLRFLLGVAEAG 129
Cdd:cd17474 24 AIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 130 FFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWilegfhdaLGLRGWQWMFLIEGLPVVLLGVVVWCSLPE 209
Cdd:cd17474 104 LGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGL--------LAAISWRYPFFLLAALIPVAFLAILFLLPE 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 210 SFERVTWLSDeqkhllreelageeqrKTITSFSGIFSNPQVWLLVAIYFAVMLAVNTIAFWMPSLIHGAGIAQDSRIGML 289
Cdd:cd17474 176 PKEKAKSSSA----------------TKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 290 SAVPYLAGCAFMIFIGRSSDRLRERRWHLGIPLLMAAAGLSLAALAPTSAWLVMgGLVIAGMGASAALPMFWQLPPAFLS 369
Cdd:cd17474 240 FAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLI-AIVLFGLGLGLNLPLLTTLVTELAP 318
|
330 340
....*....|....*....|....*....
gi 15599321 370 SATLAAGIALISSFGSIAAFLAPYLIGWM 398
Cdd:cd17474 319 EEERGTASSLYNFVRFLGQAVGPLLFGLL 347
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
118-191 |
1.68e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 43.72 E-value: 1.68e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15599321 118 LLRFLLGVAEAGFFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFhdalglrGWQWMFLI 191
Cdd:cd17503 89 IFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNL-------SWRWIFYI 155
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
52-191 |
3.87e-04 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 42.29 E-value: 3.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 52 SADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACLMLVWGCLSTAM-LLVETARGFYLLRFLLGVAEAGF 130
Cdd:TIGR00886 29 KDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAgLAVQSYSVLLLIRLFIGIAGGSF 108
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15599321 131 FPGiLVYLNRWFPARRRGQITALFA----IAVPMAGVIGGPLSGWILEGFHDALGLrGWQWMFLI 191
Cdd:TIGR00886 109 ASC-MPWISFFFPKKIQGTALGLAAgwgnMGGGVAQFVMPPIIGSLIFGGGQPAHL-AWGWAFVI 171
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
46-400 |
3.96e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.21 E-value: 3.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 46 FAKLQMSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACLMLVWGCLSTAMLLVETARGFYLLRFLLGV 125
Cdd:cd17329 21 FMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 126 AEAGFFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGfhdalglrGWQWMFLIEGLPVVLLGVVVWC 205
Cdd:cd17329 101 GGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY--------SFRLLFLAAAVLFLLAALVLLF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 206 SLPESFERvtwlsdeqkhllREELAGEEQRKTITSFsgiFSNPQVWLLVAIYFAVMLAVNTIAFWMPSLIHGAGIAQDSR 285
Cdd:cd17329 173 LLPETRPK------------RRAAEKTEILRGYKIV---LRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 286 IGMLSAVPYLAGCAFMIFIGRSSDRLRERRWhLGIPLLMAAAGLSLAALAPTSAWLVMGGLVIAgMGASAALPMFWQLPP 365
Cdd:cd17329 238 LGLLLALNALLIVLLQFPVARLVERFRLRKI-LMIGILLFAIGFAVLAFANTLAVLILAMIVLT-LGEMLVFPAVQTLVA 315
|
330 340 350
....*....|....*....|....*....|....*
gi 15599321 366 AFLSSATLAAGIALISSFGSIAAFLAPYLIGWMRD 400
Cdd:cd17329 316 ALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLD 350
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
129-191 |
4.93e-04 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 42.37 E-value: 4.93e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15599321 129 GFFPGILVYLN-----RWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFHdalglrgWQWMFLI 191
Cdd:TIGR00711 101 GFGGGPLIPLSfstllNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYH-------WRWIFLI 161
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
25-191 |
7.49e-04 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 41.62 E-value: 7.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 25 RLMPLLLVCYVFAHLDRINIGFAKLQMSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACLMLVWGCLS 104
Cdd:cd17488 3 HILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIIN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 105 TAMLLVETARGFYLLRFLLGVAEAGFFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFhdalglrG 184
Cdd:cd17488 83 ILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTY-------G 155
|
....*..
gi 15599321 185 WQWMFLI 191
Cdd:cd17488 156 WRAGMYV 162
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
55-191 |
8.08e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.45 E-value: 8.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 55 LHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIACLMLVWGCLSTAMLLVETARGFYLLRFLLGVAEAGFFPGI 134
Cdd:cd06173 239 LGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPL 318
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 15599321 135 LVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFhdalglrGWQWMFLI 191
Cdd:cd06173 319 NTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL-------GLSAVFLL 368
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
51-191 |
1.12e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 41.01 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 51 MSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRW--IACLMLVWGCLSTAMLLVETARGFYLLRFLLGVAEA 128
Cdd:COG2271 207 LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKlvLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLG 286
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15599321 129 GFFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFhdalglrGWQWMFLI 191
Cdd:COG2271 287 GAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT-------GYQAAFLL 342
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
253-398 |
1.21e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.86 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 253 LVAIYFAVMLAVNTIAFWMPSLIHGAGIAQDSRIGMLSAVPYLAGCAFMIFIGRSSDRLRERRwhLGIPLLMAAAGLSLA 332
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRR--VLLIGLLLFALGLLL 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15599321 333 ALAPTSAWLVMGGLVIAGMGASAALPMFWQLPPAFLSSATLAAGIALISSFGSIAAFLAPYLIGWM 398
Cdd:pfam07690 79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL 144
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
147-361 |
2.49e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 39.90 E-value: 2.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 147 RGQITALFAIAVPMAGVIGGPLSGWILEGFHDALGLRGWQWMFLIeglPVVLLGVVVWCSLPESFERVtwlsdeqkhllR 226
Cdd:cd17332 134 RTSLTSWRMFFATIGGLLVTVLPPPLVAYFGGGNASRGYFLTALI---IGIIGIILLLICFFGTRERV-----------V 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 227 EELAGEEQRKTITSFSGIFSNPQVWLLVAIYFAVMLAVNTIAFWMPSLIHGAGIAQDSRIGMLSAVPYLAGCAFMIFIGR 306
Cdd:cd17332 200 PPEEEKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPL 279
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 15599321 307 SSDRLRERRWHLGIpLLMAAAGLSLAALAPTSAWLVMGGLVIAGMGASAALPMFW 361
Cdd:cd17332 280 KKRFGKKKAFFIGL-LLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPW 333
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
119-315 |
3.70e-03 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 39.34 E-value: 3.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 119 LRFLLGVAEAGFFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFhdalglRGWQWMFLIEGLPVVL 198
Cdd:TIGR00894 137 CRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESW------GGWPMIFYVFGIVGCA 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 199 LGVVVWCSLPESFERVTWLSDEQKHLLREELageEQRKTITS----FSGIFSNPQVWLLVAIYFAVMLAVNTIAFWMPSL 274
Cdd:TIGR00894 211 WSLLWFVFPADDPSIHPCISKFEKKYINSSL---QGQKGSTRqslpIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTF 287
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 15599321 275 IHGAGIAQDSRIGMLSAVPYLAGCAFMIFIGRSSDRLRERR 315
Cdd:TIGR00894 288 ISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSSK 328
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
50-403 |
4.77e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 39.10 E-value: 4.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 50 QMSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGpRRWIACLMLVWGCLST-AMLLVETARGFYLLRFLLGVAEA 128
Cdd:cd17320 24 AIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFG-RRPVLLAGLLLFILASlLCALASSIEQLLIARFLQGLGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 129 GFFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFhdalglrGWQWMFLIEGLPVVLLGVVVWCSLP 208
Cdd:cd17320 103 AGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFF-------GWRAIFVFLALLGLLLLLLVLLFLP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 209 ESfervtwlsdeqkhlLREELAGEEQRKTITSFSGIFSNPQVW---LLVAIYFAVMLAVNTIAFWMPSLIHGAGIAQDSR 285
Cdd:cd17320 176 ET--------------LPEEKRKPLLSSLLRAYKRVLKNRRFLgyaLALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 286 IGMLSAVPYLAGCAFMIFIGRSSDRLRERRWHLGIPLLMAAAGLSLAALAPTSAWLVMGGLVIAGMGASAALPMfwqLPP 365
Cdd:cd17320 242 LFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPN---ATS 318
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 15599321 366 AFLSSATLAAGIA--LISSFGSIAAFLAPYLIGWMRDTTQ 403
Cdd:cd17320 319 LALEPFPHVAGTAsaLLGFLQFLIGALAGALVGLLPNGTA 358
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
67-398 |
5.34e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 38.79 E-value: 5.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 67 GLFFIAyALFGLPSNLML-----ERIGPRRWIACLMLVWGCLSTAMLLVETARGFYLLRFLLGVAEAGFFPGILVYLNRW 141
Cdd:PRK11551 53 GWAFSA-GILGLLPGALLggrlaDRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEA 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 142 FPARRRGQITALFAIAVPMAGVIGGPLSgwILEGFHDalglrGWQWMFLIEGLPVVLLGVVVWCSLPES--FERVTWLSD 219
Cdd:PRK11551 132 VGPRLRGTAVSLMYCGVPFGGALASVIG--VLAAGDA-----AWRHIFYVGGVGPLLLVPLLMRWLPESraFAQAAGAGK 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 220 eQKHLLREELAGEEQRKTITsfsgifsnpQVWLlvaIYFAVMLAVNTIAFWMPSLIHGAGIAQdSRIGMLSAVPYLAGCA 299
Cdd:PRK11551 205 -QRAPVLRALFGEGRATATL---------LLWI---SYFFTLIVLYFLLNWLPSLLVGQGLSR-SQAGLVQIAFNIGGAL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 300 FMIFIGRSSDRLRERRWHLGIpLLMAAAGLSLAALAPTSAWLVMGGLViAGMGASAALPMFWQLPPAFLSSATLAAGIAL 379
Cdd:PRK11551 271 GSLLIGALMDRLRPRRVVLLI-YAGILASLAALAAAPSFAGMLLAGFA-AGLFVVGGQSVLYALAPLFYPTQVRGTGVGA 348
|
330
....*....|....*....
gi 15599321 380 ISSFGSIAAFLAPYLIGWM 398
Cdd:PRK11551 349 AVAVGRLGSMAGPLLAGQL 367
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
50-402 |
8.90e-03 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 37.94 E-value: 8.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 50 QMSADLHFSDTVYGLGAGLFFIAYALFGLPSNLMLERIGPRRWIAcLMLVWGCLSTAMLLVETARGFYLLRFLLGVAEAG 129
Cdd:cd17339 24 EIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLL-LALLLLAAGILLRSLGGIALLFLGTALAGAGIAV 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 130 ---FFPGILvylNRWFPaRRRGQITALFAIAVPMAGVIGGPLSGWILEGFHDalglrGWQWMFLIeglpvvllgvvvWcS 206
Cdd:cd17339 103 gnvLLPSLI---KRDFP-RRVGLMTGLYTTSMNLGAALASGLSVPLAQALGG-----GWRGALAI------------W-A 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 207 LPESFERVTWLSdeqKHLLREELAgeeQRKTITSFSGIFSNPQVWLlVAIYFAVM-LAVNTIAFWMPSLIHGAGIAQDSR 285
Cdd:cd17339 161 LPALLALLIWLP---QLRRRKRAA---AAAAPLTKISVWRSPLAWQ-VTLFMGLQsLLFYTLMAWLPTILIDAGLSAATA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599321 286 IGMLSAVPyLAGCAFMIFIGRSSDRLRERRWHLGIPLLMAAAGLSLAALAPTSAWLVmgGLVIAGMGASAALPMFWQLPP 365
Cdd:cd17339 234 GWLLSLFQ-LVGIPASLLVPILATRLKNQRPIVVLLAVLFIIGVLGLLFAPTALALL--WAVLLGLGGGAAFSLALTLIS 310
|
330 340 350
....*....|....*....|....*....|....*...
gi 15599321 366 AFLSSATLAAGI-ALISSFGSIAAFLAPYLIGWMRDTT 402
Cdd:cd17339 311 LRSSDPAEAAALsGMAQSVGYLLAALGPLLFGVLHDLT 348
|
|
| |
