|
Name |
Accession |
Description |
Interval |
E-value |
| obgE |
PRK12298 |
GTPase CgtA; Reviewed |
1-372 |
0e+00 |
|
GTPase CgtA; Reviewed
Pssm-ID: 237047 [Multi-domain] Cd Length: 390 Bit Score: 642.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 1 MKFVDEVSIHVKAGDGGNGLMSFRREKFIEKGGPNGGDGGDGGSIYLEADVNLNTLVDYRYTRRFDAQRGENGGSKDCTG 80
Cdd:PRK12298 1 MKFVDEAKIRVVAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVYLEADENLNTLIDYRFERHFRAERGQNGQGRDCTG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 81 AKGDDLILPVPVGTTVIDANTQEIIGDLTEPGQRLMVAQGGWHGLGNTRFKSSTNRAPRQTTPGKPGEARDLKLELKVLA 160
Cdd:PRK12298 81 KRGKDITIKVPVGTRVIDADTGEVIGDLTEHGQRLLVAKGGWHGLGNTRFKSSVNRAPRQKTPGTPGEERELKLELKLLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 161 DVGLLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPNLGVVSVGRYKSFVVADIPGLIEGAAEGAGLGIRFLKHLARTRI 240
Cdd:PRK12298 161 DVGLLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPNLGVVRVDDERSFVVADIPGLIEGASEGAGLGIRFLKHLERCRV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 241 LLHLVDMAPLDESDPADAAEVIVRELGRFSPALTERERWLVLNKMDQILDPaEREARKQAVIERLGWEGPVYVISALERD 320
Cdd:PRK12298 241 LLHLIDIAPIDGSDPVENARIIINELEKYSPKLAEKPRWLVFNKIDLLDEE-EAEERAKAIVEALGWEGPVYLISAASGL 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 15599762 321 GTEALSQDIMRYLDERTlrlEEDPQYAEELAELDRRIEDEARARLQALDDAR 372
Cdd:PRK12298 320 GVKELCWDLMTFIEENP---REEAEEAEAPEKVEFMWDDYHREQLEEVEEED 368
|
|
| Obg |
COG0536 |
GTPase involved in cell partioning and DNA repair [Cell cycle control, cell division, ... |
3-349 |
0e+00 |
|
GTPase involved in cell partioning and DNA repair [Cell cycle control, cell division, chromosome partitioning, Replication, recombination, and repair];
Pssm-ID: 440302 [Multi-domain] Cd Length: 343 Bit Score: 580.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 3 FVDEVSIHVKAGDGGNGLMSFRREKFIEKggpnggdggdggSIYLEADVNLNTLVDYRYTRRFDAQRGENGGSKDCTGAK 82
Cdd:COG0536 1 FVDEAKIYVKAGDGGNGCVSFRREKYVPKggpdggdggrggDVILVADENLNTLLDFRYKRHFKAENGENGMGKNRTGKN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 83 GDDLILPVPVGTTVIDANTQEIIGDLTEPGQRLMVAQGGWHGLGNTRFKSSTNRAPRQTTPGKPGEARDLKLELKVLADV 162
Cdd:COG0536 81 GEDLVIKVPVGTVVKDAETGEVLADLTEDGQRVVVAKGGRGGLGNAHFKSSTNRAPRFAEPGEPGEERWLRLELKLLADV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 163 GLLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPNLGVVSVGRYKSFVVADIPGLIEGAAEGAGLGIRFLKHLARTRILL 242
Cdd:COG0536 161 GLVGLPNAGKSTLLSAVSAAKPKIADYPFTTLVPNLGVVRVGDGRSFVIADIPGLIEGASEGAGLGHRFLRHIERTRVLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 243 HLVDMAPLDESDPADAAEVIVRELGRFSPALTERERWLVLNKMDqILDPAEREArKQAVIERLGweGPVYVISALERDGT 322
Cdd:COG0536 241 HVVDAAPLDGRDPVEDYEIIRNELEAYSPELAEKPRIVVLNKID-LLDAEELEE-LKAELEKLG--GPVFPISAVTGEGL 316
|
330 340
....*....|....*....|....*..
gi 15599762 323 EALSQDIMRYLDERTLRLEEDPQYAEE 349
Cdd:COG0536 317 DELLYALAELLEELRAEEAEEEEEVEE 343
|
|
| Obg_CgtA |
TIGR02729 |
Obg family GTPase CgtA; This model describes a univeral, mostly one-gene-per-genome ... |
3-333 |
0e+00 |
|
Obg family GTPase CgtA; This model describes a univeral, mostly one-gene-per-genome GTP-binding protein that associates with ribosomal subunits and appears to play a role in ribosomal RNA maturation. This GTPase, related to the nucleolar protein Obg, is designated CgtA in bacteria. Mutations in this gene are pleiotropic, but it appears that effects on cellular functions such as chromosome partition may be secondary to the effect on ribosome structure. Recent work done in Vibrio cholerae shows an essential role in the stringent response, in which RelA-dependent ability to synthesize the alarmone ppGpp is required for deletion of this GTPase to be lethal. [Protein synthesis, Other]
Pssm-ID: 274271 [Multi-domain] Cd Length: 328 Bit Score: 573.60 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 3 FVDEVSIHVKAGDGGNGLMSFRREKFIEKGGPNGGDGGDGGSIYLEADVNLNTLVDYRYTRRFDAQRGENGGSKDCTGAK 82
Cdd:TIGR02729 1 FVDEAKIFVKAGDGGNGCVSFRREKYVPKGGPDGGDGGRGGSVILEADENLNTLLDFRYQRHFKAENGENGMGKNRTGKS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 83 GDDLILPVPVGTTVIDANTQEIIGDLTEPGQRLMVAQGGWHGLGNTRFKSSTNRAPRQTTPGKPGEARDLKLELKVLADV 162
Cdd:TIGR02729 81 GEDLVIKVPVGTVVYDADTGELLADLTEPGQRFLVAKGGRGGLGNAHFKSSTNRAPRFATPGEPGEERWLRLELKLLADV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 163 GLLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPNLGVVSVGRYKSFVVADIPGLIEGAAEGAGLGIRFLKHLARTRILL 242
Cdd:TIGR02729 161 GLVGLPNAGKSTLISAVSAAKPKIADYPFTTLVPNLGVVRVDDGRSFVIADIPGLIEGASEGAGLGHRFLKHIERTRVLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 243 HLVDMAPLDESDPADAAEVIVRELGRFSPALTERERWLVLNKMDqILDPAEREARKQAVIERLGWegPVYVISALERDGT 322
Cdd:TIGR02729 241 HLIDISPEDGSDPVEDYEIIRNELKKYSPELAEKPRIVVLNKID-LLDEEELEELLKELKKELGK--PVFPISALTGEGL 317
|
330
....*....|.
gi 15599762 323 EALSQDIMRYL 333
Cdd:TIGR02729 318 DELLDALAELL 328
|
|
| obgE |
PRK12299 |
GTPase CgtA; Reviewed |
2-335 |
0e+00 |
|
GTPase CgtA; Reviewed
Pssm-ID: 237048 [Multi-domain] Cd Length: 335 Bit Score: 555.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 2 KFVDEVSIHVKAGDGGNGLMSFRREKFIEKggpnggdggdggSIYLEADVNLNTLVDYRYTRRFDAQRGENGGSKDCTGA 81
Cdd:PRK12299 1 KFIDEAKIYVKAGDGGNGCVSFRREKFIPFggpdggdggrggSVILEADENLNTLIDFRYKRHFKAENGENGMGRNRTGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 82 KGDDLILPVPVGTTVIDANTQEIIGDLTEPGQRLMVAQGGWHGLGNTRFKSSTNRAPRQTTPGKPGEARDLKLELKVLAD 161
Cdd:PRK12299 81 SGKDLVLKVPVGTQIYDADTGELIADLTEHGQRFLVAKGGKGGLGNAHFKSSTNRAPRYATPGEPGEERWLRLELKLLAD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 162 VGLLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPNLGVVSVGRYKSFVVADIPGLIEGAAEGAGLGIRFLKHLARTRIL 241
Cdd:PRK12299 161 VGLVGLPNAGKSTLISAVSAAKPKIADYPFTTLHPNLGVVRVDDYKSFVIADIPGLIEGASEGAGLGHRFLKHIERTRLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 242 LHLVDMApldESDPADAAEVIVRELGRFSPALTERERWLVLNKMDQILDPAEREARKQAVIERLGweGPVYVISALERDG 321
Cdd:PRK12299 241 LHLVDIE---AVDPVEDYKTIRNELEKYSPELADKPRILVLNKIDLLDEEEEREKRAALELAALG--GPVFLISAVTGEG 315
|
330
....*....|....
gi 15599762 322 TEALSQDIMRYLDE 335
Cdd:PRK12299 316 LDELLRALWELLEE 329
|
|
| obgE |
PRK12297 |
GTPase CgtA; Reviewed |
2-385 |
3.21e-161 |
|
GTPase CgtA; Reviewed
Pssm-ID: 237046 [Multi-domain] Cd Length: 424 Bit Score: 459.95 E-value: 3.21e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 2 KFVDEVSIHVKAGDGGNGLMSFRREKFIEKggpnggdggdggSIYLEADVNLNTLVDYRYTRRFDAQRGENGGSKDCTGA 81
Cdd:PRK12297 1 MFIDQAKIYVKAGDGGDGMVSFRREKYVPKggpdggdggkggSVIFVADEGLRTLLDFRYKRHFKAENGENGMGKNMHGR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 82 KGDDLILPVPVGTTVIDANTQEIIGDLTEPGQRLMVAQGGWHGLGNTRFKSSTNRAPRQTTPGKPGEARDLKLELKVLAD 161
Cdd:PRK12297 81 NGEDLIIKVPVGTVVKDAETGEVIADLVEPGQEVVVAKGGRGGRGNAHFATSTNQAPRIAENGEPGEERELRLELKLLAD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 162 VGLLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPNLGVVSVGRYKSFVVADIPGLIEGAAEGAGLGIRFLKHLARTRIL 241
Cdd:PRK12297 161 VGLVGFPNVGKSTLLSVVSNAKPKIANYHFTTLVPNLGVVETDDGRSFVMADIPGLIEGASEGVGLGHQFLRHIERTRVI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 242 LHLVDMAPLDESDPADAAEVIVRELGRFSPALTERERWLVLNKMDQildpAEREARKQAVIERLGWEgpVYVISALERDG 321
Cdd:PRK12297 241 VHVIDMSGSEGRDPIEDYEKINKELKLYNPRLLERPQIVVANKMDL----PEAEENLEEFKEKLGPK--VFPISALTGQG 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 322 TEALSQDIMRYLDERTLRLEEDPQYAEEL-------------------------AELDRRIE------DEARARLQaldd 370
Cdd:PRK12297 315 LDELLYAVAELLEETPEFPLEEEEVEEEVyykfeeeekdftitrdedgvfvvsgEKIERLFKmtnfnrDESLRRFA---- 390
|
410
....*....|....*....
gi 15599762 371 aRALRRSG----LKNAGAV 385
Cdd:PRK12297 391 -RQLRKMGvddaLREAGAK 408
|
|
| obgE |
PRK12296 |
GTPase CgtA; Reviewed |
1-326 |
1.79e-112 |
|
GTPase CgtA; Reviewed
Pssm-ID: 237045 [Multi-domain] Cd Length: 500 Bit Score: 338.38 E-value: 1.79e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 1 MKFVDEVSIHVKAGDGGNGLMSFRREKFIEKGGPNGGDGGDGGSIYLEADVNLNTLVDYRYTRRFDAQRGENGGSKDCTG 80
Cdd:PRK12296 2 PRFVDRVVLHVKAGDGGNGCASVHREKFKPLGGPDGGNGGRGGSVVLVVDPQVTTLLDFHFRPHRKATNGKPGMGDNRDG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 81 AKGDDLILPVPVGTtVIDANTQEIIGDLTEPGQRLMVAQGGWHGLGNTRFKSSTNRAPRQTTPGKPGEARDLKLELKVLA 160
Cdd:PRK12296 82 AAGEDLVLPVPDGT-VVLDEDGEVLADLVGAGTRFVAAAGGRGGLGNAALASKARKAPGFALLGEPGEERDLVLELKSVA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 161 DVGLLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPNLGVVSVGRYkSFVVADIPGLIEGAAEGAGLGIRFLKHLARTRI 240
Cdd:PRK12296 161 DVGLVGFPSAGKSSLISALSAAKPKIADYPFTTLVPNLGVVQAGDT-RFTVADVPGLIPGASEGKGLGLDFLRHIERCAV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 241 LLHLVDMAPLDES-DPADAAEVIVRELGRFSPA---------LTERERWLVLNKMDqILDPAEREARKQAVIERLGWegP 310
Cdd:PRK12296 240 LVHVVDCATLEPGrDPLSDIDALEAELAAYAPAldgdlglgdLAERPRLVVLNKID-VPDARELAEFVRPELEARGW--P 316
|
330
....*....|....*.
gi 15599762 311 VYVISALERDGTEALS 326
Cdd:PRK12296 317 VFEVSAASREGLRELS 332
|
|
| Obg |
cd01898 |
Obg GTPase; The Obg nucleotide binding protein subfamily has been implicated in stress ... |
160-333 |
7.76e-94 |
|
Obg GTPase; The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins conserved from bacteria to humans. The E. coli homolog, ObgE is believed to function in ribosomal biogenesis. Members of the subfamily contain two equally and highly conserved domains, a C-terminal GTP binding domain and an N-terminal glycine-rich domain.
Pssm-ID: 206685 [Multi-domain] Cd Length: 170 Bit Score: 278.92 E-value: 7.76e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 160 ADVGLLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPNLGVVSVGRYKSFVVADIPGLIEGAAEGAGLGIRFLKHLARTR 239
Cdd:cd01898 1 ADVGLVGLPNAGKSTLLSAISNAKPKIADYPFTTLVPNLGVVRVDDGRSFVIADIPGLIEGASEGKGLGHRFLRHIERTR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 240 ILLHLVDMAPLDesDPADAAEVIVRELGRFSPALTERERWLVLNKMDqILDPAEREARKQAVIERLgWEGPVYVISALER 319
Cdd:cd01898 81 VLLHVIDLSGED--DPVEDYETIRNELEAYNPGLAEKPRIVVLNKID-LLDAEERFEKLKELLKEL-KGKKVFPISALTG 156
|
170
....*....|....
gi 15599762 320 DGTEALSQDIMRYL 333
Cdd:cd01898 157 EGLDELLKKLAKLL 170
|
|
| GTP1_OBG |
pfam01018 |
GTP1/OBG; The N-terminal domain of Swiss:P20964 has the OBG fold, which is formed by three ... |
4-158 |
8.76e-78 |
|
GTP1/OBG; The N-terminal domain of Swiss:P20964 has the OBG fold, which is formed by three glycine-rich regions inserted into a small 8-stranded beta-sandwich these regions form six left-handed collagen-like helices packed and H-bonded together.
Pssm-ID: 460027 [Multi-domain] Cd Length: 155 Bit Score: 237.24 E-value: 8.76e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 4 VDEVSIHVKAGDGGNGLMSFRREKFIEKGGPNGGDGGDGGSIYLEADVNLNTLVDYRYTRRFDAQRGENGGSKDCTGAKG 83
Cdd:pfam01018 1 VDRAKIKVKAGDGGNGCVSFRREKYVPKGGPDGGDGGRGGDVILVADENLNTLLDFRYKRHFKAENGENGGGKNCHGKNG 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15599762 84 DDLILPVPVGTTVIDANTQEIIGDLTEPGQRLMVAQGGWHGLGNTRFKSSTNRAPRQTTPGKPGEARDLKLELKV 158
Cdd:pfam01018 81 EDLIIKVPVGTVVKDAETGEVLADLTEPGQRVLVAKGGRGGRGNAHFKTSTNQAPRFAEPGEPGEERWLELELKL 155
|
|
| Obg_like |
cd01881 |
Obg-like family of GTPases consist of five subfamilies: Obg, DRG, YyaF/YchF, Ygr210, and NOG1; ... |
163-323 |
1.34e-35 |
|
Obg-like family of GTPases consist of five subfamilies: Obg, DRG, YyaF/YchF, Ygr210, and NOG1; The Obg-like subfamily consists of five well-delimited, ancient subfamilies, namely Obg, DRG, YyaF/YchF, Ygr210, and NOG1. Four of these groups (Obg, DRG, YyaF/YchF, and Ygr210) are characterized by a distinct glycine-rich motif immediately following the Walker B motif (G3 box). Obg/CgtA is an essential gene that is involved in the initiation of sporulation and DNA replication in the bacteria Caulobacter and Bacillus, but its exact molecular role is unknown. Furthermore, several OBG family members possess a C-terminal RNA-binding domain, the TGS domain, which is also present in threonyl-tRNA synthetase and in bacterial guanosine polyphosphatase SpoT. Nog1 is a nucleolar protein that might function in ribosome assembly. The DRG and Nog1 subfamilies are ubiquitous in archaea and eukaryotes, the Ygr210 subfamily is present in archaea and fungi, and the Obg and YyaF/YchF subfamilies are ubiquitous in bacteria and eukaryotes. The Obg/Nog1 and DRG subfamilies appear to form one major branch of the Obg family and the Ygr210 and YchF subfamilies form another branch. No GEFs, GAPs, or GDIs for Obg have been identified.
Pssm-ID: 206668 [Multi-domain] Cd Length: 167 Bit Score: 128.67 E-value: 1.34e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 163 GLLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPNLGVVSVGRYKSFVVADIPGLIEGAAEGAGLGIRFLKHLARTRILL 242
Cdd:cd01881 1 GLVGLPNVGKSTLLSALTSAKVEIASYPFTTLEPNVGVFEFGDGVDIQIIDLPGLLDGASEGRGLGEQILAHLYRSDLIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 243 HLVDMAPLDESDPADAAEVIVRELGRFSPALTERERWLVLNKMDQildpAEREARKQAVIERLGWEGPVYVISALERDGT 322
Cdd:cd01881 81 HVIDASEDCVGDPLEDQKTLNEEVSGSFLFLKNKPEMIVANKIDM----ASENNLKRLKLDKLKRGIPVVPTSALTRLGL 156
|
.
gi 15599762 323 E 323
Cdd:cd01881 157 D 157
|
|
| MMR_HSR1 |
pfam01926 |
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ... |
161-284 |
2.12e-28 |
|
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.
Pssm-ID: 460387 [Multi-domain] Cd Length: 113 Bit Score: 107.71 E-value: 2.12e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 161 DVGLLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPNLGVVSVGRYKsFVVADIPGLIEGAAEGAGLGIRFLKHLaRTRI 240
Cdd:pfam01926 1 RVALVGRPNVGKSTLINALTGAKAIVSDYPGTTRDPNEGRLELKGKQ-IILVDTPGLIEGASEGEGLGRAFLAII-EADL 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 15599762 241 LLHLVDMapldeSDPADAAEVIVRELGRFSpaltERERWLVLNK 284
Cdd:pfam01926 79 ILFVVDS-----EEGITPLDEELLELLREN----KKPIILVLNK 113
|
|
| Era_like |
cd00880 |
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family ... |
163-333 |
1.20e-20 |
|
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family.
Pssm-ID: 206646 [Multi-domain] Cd Length: 161 Bit Score: 88.07 E-value: 1.20e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 163 GLLGLPNAGKSTFIRAVSAAKP-KVADYPFTTLVPNLGVVSVGRYKSFVVADIPGLIEGAAEGAGLGIRFLKHLARTRIL 241
Cdd:cd00880 1 AIFGRPNVGKSSLLNALLGQNVgIVSPIPGTTRDPVRKEWELLPLGPVVLIDTPGLDEEGGLGRERVEEARQVADRADLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 242 LHLVDmaplDESDPADAAEVIVRELGRFSPALtererwLVLNKMDQILDPAEREARKQAVIERLGwEGPVYVISALERDG 321
Cdd:cd00880 81 LLVVD----SDLTPVEEEAKLGLLRERGKPVL------LVLNKIDLVPESEEEELLRERKLELLP-DLPVIAVSALPGEG 149
|
170
....*....|..
gi 15599762 322 TEALSQDIMRYL 333
Cdd:cd00880 150 IDELRKKIAELL 161
|
|
| PTZ00258 |
PTZ00258 |
GTP-binding protein; Provisional |
162-266 |
8.38e-19 |
|
GTP-binding protein; Provisional
Pssm-ID: 240334 [Multi-domain] Cd Length: 390 Bit Score: 87.31 E-value: 8.38e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 162 VGLLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPNLGVVSV--GRY---------KSFV-----VADIPGLIEGAAEGA 225
Cdd:PTZ00258 24 MGIVGLPNVGKSTTFNALCKQQVPAENFPFCTIDPNTARVNVpdERFdwlckhfkpKSIVpaqldITDIAGLVKGASEGE 103
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 15599762 226 GLGIRFLKHLARTRILLHLV------DMAPLDES-DPADAAEVIVREL 266
Cdd:PTZ00258 104 GLGNAFLSHIRAVDGIYHVVrafedeDITHVEGEiDPVRDLEIISSEL 151
|
|
| DRG |
cd01896 |
Developmentally Regulated GTP-binding protein (DRG); The developmentally regulated GTP-binding ... |
160-269 |
1.49e-18 |
|
Developmentally Regulated GTP-binding protein (DRG); The developmentally regulated GTP-binding protein (DRG) subfamily is an uncharacterized member of the Obg family, an evolutionary branch of GTPase superfamily proteins. GTPases act as molecular switches regulating diverse cellular processes. DRG2 and DRG1 comprise the DRG subfamily in eukaryotes. In view of their widespread expression in various tissues and high conservation among distantly related species in eukaryotes and archaea, DRG proteins may regulate fundamental cellular processes. It is proposed that the DRG subfamily proteins play their physiological roles through RNA binding.
Pssm-ID: 206683 [Multi-domain] Cd Length: 233 Bit Score: 84.13 E-value: 1.49e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 160 ADVGLLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPNLGVVsvgRYK--SFVVADIPGLIEGAAEGAGLGIRFLKhLAR 237
Cdd:cd01896 1 ARVALVGFPSVGKSTLLSKLTNTKSEVAAYEFTTLTCVPGVM---EYKgaKIQLLDLPGIIEGASDGKGRGRQVIA-VAR 76
|
90 100 110
....*....|....*....|....*....|..
gi 15599762 238 TRILLHLVdmapLDESDPADAAEVIVRELGRF 269
Cdd:cd01896 77 TADLILIV----LDATKPEGQREILERELEGV 104
|
|
| Ygr210 |
cd01899 |
Ygr210 GTPase; Ygr210 is a member of Obg-like family and present in archaea and fungi. They ... |
162-246 |
2.48e-18 |
|
Ygr210 GTPase; Ygr210 is a member of Obg-like family and present in archaea and fungi. They are characterized by a distinct glycine-rich motif immediately following the Walker B motif. The Ygr210 and YyaF/YchF subfamilies appear to form one major branch of the Obg-like family. Among eukaryotes, the Ygr210 subfamily is represented only in fungi. These fungal proteins form a tight cluster with their archaeal orthologs, which suggests the possibility of horizontal transfer from archaea to fungi.
Pssm-ID: 206686 [Multi-domain] Cd Length: 318 Bit Score: 84.97 E-value: 2.48e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 162 VGLLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPNLGV-------------VSVG----------RYKSFVVADIPGLI 218
Cdd:cd01899 1 IGLVGKPNVGKSTFFNAATLADVEIANYPFTTIDPNVGVgyvrvecpckelgVSCNprygkcidgkRYVPVELIDVAGLV 80
|
90 100
....*....|....*....|....*...
gi 15599762 219 EGAAEGAGLGIRFLKHLARTRILLHLVD 246
Cdd:cd01899 81 PGAHEGKGLGNQFLDDLRDADVLIHVVD 108
|
|
| Rbg1 |
COG1163 |
Ribosome-interacting GTPase RBG1 [Translation, ribosomal structure and biogenesis]; |
160-266 |
7.15e-18 |
|
Ribosome-interacting GTPase RBG1 [Translation, ribosomal structure and biogenesis];
Pssm-ID: 440777 [Multi-domain] Cd Length: 368 Bit Score: 84.46 E-value: 7.15e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 160 ADVGLLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPNLGVVsvgRYK--SFVVADIPGLIEGAAEGAGLGIRFLKhLAR 237
Cdd:COG1163 64 ATVVLVGFPSVGKSTLLNKLTNAKSEVGAYEFTTLDVVPGML---EYKgaKIQILDVPGLIEGAASGKGRGKEVLS-VVR 139
|
90 100
....*....|....*....|....*....
gi 15599762 238 TRILLHLVdmapLDESDPaDAAEVIVREL 266
Cdd:COG1163 140 NADLILIV----LDVFEL-EQYDVLKEEL 163
|
|
| PRK09602 |
PRK09602 |
translation-associated GTPase; Reviewed |
162-246 |
1.04e-17 |
|
translation-associated GTPase; Reviewed
Pssm-ID: 236584 [Multi-domain] Cd Length: 396 Bit Score: 84.09 E-value: 1.04e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 162 VGLLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPNLGVVSV-----------------GRY---KSFV---VADIPGLI 218
Cdd:PRK09602 4 IGLVGKPNVGKSTFFNAATLADVEIANYPFTTIDPNVGVAYVrvecpckelgvkcnprnGKCidgTRFIpveLIDVAGLV 83
|
90 100
....*....|....*....|....*...
gi 15599762 219 EGAAEGAGLGIRFLKHLARTRILLHLVD 246
Cdd:PRK09602 84 PGAHEGRGLGNQFLDDLRQADALIHVVD 111
|
|
| GTP1 |
COG0012 |
Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis] ... |
162-266 |
2.09e-17 |
|
Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis];
Pssm-ID: 439783 [Multi-domain] Cd Length: 362 Bit Score: 82.76 E-value: 2.09e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 162 VGLLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPNLGVVSV--GR-------YKS---------FVvaDIPGLIEGAAE 223
Cdd:COG0012 3 CGIVGLPNVGKSTLFNALTKAGAEAANYPFCTIEPNVGVVPVpdERldklaeiVKPkkivpatieFV--DIAGLVKGASK 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 15599762 224 GAGLGIRFLKHLARTRILLHLV------DMAPLDES-DPADAAEVIVREL 266
Cdd:COG0012 81 GEGLGNQFLANIREVDAIVHVVrcfeddNVTHVEGSvDPLRDIETINTEL 130
|
|
| YchF |
cd01900 |
YchF GTPase; YchF is a member of the Obg family, which includes four other subfamilies of ... |
162-245 |
1.02e-15 |
|
YchF GTPase; YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated with the ribosome. Several members of the family, including YchF, possess the TGS domain related to the RNA-binding proteins. Experimental data and genomic analysis suggest that YchF may be part of a nucleoprotein complex and may function as a GTP-dependent translational factor.
Pssm-ID: 206687 [Multi-domain] Cd Length: 274 Bit Score: 76.73 E-value: 1.02e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 162 VGLLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPNLGVVSV--GR-------YKS---------FVvaDIPGLIEGAAE 223
Cdd:cd01900 1 IGIVGLPNVGKSTLFNALTKSNAEAANYPFCTIEPNVGIVPVpdERldklaeiVKPkkivpatieFV--DIAGLVKGASK 78
|
90 100
....*....|....*....|..
gi 15599762 224 GAGLGIRFLKHLARTRILLHLV 245
Cdd:cd01900 79 GEGLGNKFLSHIREVDAIAHVV 100
|
|
| Nog1 |
COG1084 |
GTP-binding protein, GTP1/Obg family [General function prediction only]; |
147-335 |
3.31e-15 |
|
GTP-binding protein, GTP1/Obg family [General function prediction only];
Pssm-ID: 440701 [Multi-domain] Cd Length: 330 Bit Score: 76.02 E-value: 3.31e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 147 GEARDlklELKVLADVG-------LLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPNLGVVSVGRYKsFVVADIPGL-- 217
Cdd:COG1084 144 NEARN---KLRKLPDIDpdlptivVAGYPNVGKSSLVSKVTSAKPEIASYPFTTKGIIVGHFERGHGR-YQVIDTPGLld 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 218 --------IEGAAEGAglgirfLKHLArtRILLHLVD------------MAPLDEsdpadaaeviVRELgrFS-PALTer 276
Cdd:COG1084 220 rplserneIERQAILA------LKHLA--DVILFLFDpsetcgysleeqLNLLEE----------IRSL--FDvPVIV-- 277
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 15599762 277 erwlVLNKMDQILDPAEREARKQAVIErlgwegpvyvISALERDGTEALSQDIMRYLDE 335
Cdd:COG1084 278 ----VINKIDLSDEEELKEAEEEADIK----------ISALTGEGVDELLDELIEALEE 322
|
|
| Ras_like_GTPase |
cd00882 |
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ... |
163-331 |
3.95e-14 |
|
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.
Pssm-ID: 206648 [Multi-domain] Cd Length: 161 Bit Score: 69.79 E-value: 3.95e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 163 GLLGLPNAGKSTFIRAVSAAK-PKVADYPFTTLVPNLGVVSVGRYK-SFVVADIPGLIEGaaEGAGLGIRFLKHLARTRI 240
Cdd:cd00882 1 VVVGRGGVGKSSLLNALLGGEvGEVSDVPGTTRDPDVYVKELDKGKvKLVLVDTPGLDEF--GGLGREELARLLLRGADL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 241 LLHLVDMApLDESDPADAAEVIVRELGRFSPALtererwLVLNKMDQILDPAEREARKQAVIERLGwEGPVYVISALERD 320
Cdd:cd00882 79 ILLVVDST-DRESEEDAKLLILRRLRKEGIPII------LVGNKIDLLEEREVEELLRLEELAKIL-GVPVFEVSAKTGE 150
|
170
....*....|.
gi 15599762 321 GTEALSQDIMR 331
Cdd:cd00882 151 GVDELFEKLIE 161
|
|
| Era |
cd04163 |
E. coli Ras-like protein (Era) is a multifunctional GTPase; Era (E. coli Ras-like protein) is ... |
162-333 |
2.94e-12 |
|
E. coli Ras-like protein (Era) is a multifunctional GTPase; Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly by chaperoning the 16S rRNA. It also contacts several assembly elements of the 30S subunit. Era couples cell growth with cytokinesis and plays a role in cell division and energy metabolism. Homologs have also been found in eukaryotes. Era contains two domains: the N-terminal GTPase domain and a C-terminal domain KH domain that is critical for RNA binding. Both domains are important for Era function. Era is functionally able to compensate for deletion of RbfA, a cold-shock adaptation protein that is required for efficient processing of the 16S rRNA.
Pssm-ID: 206726 [Multi-domain] Cd Length: 168 Bit Score: 64.40 E-value: 2.94e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 162 VGLLGLPNAGKSTFIRA-----VSAAKPKvadyPFTTLVPNLGVVSVGRYKsFVVADIPGLIEgaaEGAGLGiRFLKHLA 236
Cdd:cd04163 6 VAIIGRPNVGKSTLLNAlvgqkISIVSPK----PQTTRNRIRGIYTDDDAQ-IIFVDTPGIHK---PKKKLG-ERMVKAA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 237 RTRI-----LLHLVDMAplDESDPADaaEVIVRELGRfspalTERERWLVLNKMDQILDPAEREARKQAVIERLGWEgPV 311
Cdd:cd04163 77 WSALkdvdlVLFVVDAS--EWIGEGD--EFILELLKK-----SKTPVILVLNKIDLVKDKEDLLPLLEKLKELHPFA-EI 146
|
170 180
....*....|....*....|..
gi 15599762 312 YVISALERDGTEALSQDIMRYL 333
Cdd:cd04163 147 FPISALKGENVDELLEYIVEYL 168
|
|
| HflX |
cd01878 |
HflX GTPase family; HflX subfamily. A distinct conserved domain with a glycine-rich segment ... |
162-333 |
6.11e-11 |
|
HflX GTPase family; HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual biological functions of these GTPases remain unclear. HflX is widespread, but not universally represented in all three superkingdoms.
Pssm-ID: 206666 [Multi-domain] Cd Length: 204 Bit Score: 61.32 E-value: 6.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 162 VGLLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPNLGVVSVGRYKSFVVADIPGLIEG------AAegaglgirFLKHL 235
Cdd:cd01878 44 VALVGYTNAGKSTLFNALTGADVLAEDQLFATLDPTTRRIKLPGGREVLLTDTVGFIRDlphqlvEA--------FRSTL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 236 ARTR---ILLHLVDMAPLDESDPADAAEVIVRELGrfspaLTERERWLVLNKMDQILDPAEREARKQAVIERLgwegpvy 312
Cdd:cd01878 116 EEVAeadLLLHVVDASDPDREEQIETVEEVLKELG-----ADDIPIILVLNKIDLLDDEELEERLRAGRPDAV------- 183
|
170 180
....*....|....*....|.
gi 15599762 313 VISALERDGTEALSQDIMRYL 333
Cdd:cd01878 184 FISAKTGEGLDLLKEAIEELL 204
|
|
| Era |
COG1159 |
GTPase Era, involved in 16S rRNA processing [Translation, ribosomal structure and biogenesis]; |
162-335 |
1.53e-10 |
|
GTPase Era, involved in 16S rRNA processing [Translation, ribosomal structure and biogenesis];
Pssm-ID: 440773 [Multi-domain] Cd Length: 290 Bit Score: 61.54 E-value: 1.53e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 162 VGLLGLPNAGKSTFIRA-----VSAAKPKvadyPFTTLVPNLGVVSVGRYKsFVVADIPGLIEGAAEgagLGiRFLKHLA 236
Cdd:COG1159 6 VAIVGRPNVGKSTLLNAlvgqkVSIVSPK----PQTTRHRIRGIVTREDAQ-IVFVDTPGIHKPKRK---LG-RRMNKAA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 237 RTRI-----LLHLVD-MAPLDESDpadaaEVIVRELGRfspalTERERWLVLNKMDQIlDPAEREARKQAVIERLGWEgP 310
Cdd:COG1159 77 WSALedvdvILFVVDaTEKIGEGD-----EFILELLKK-----LKTPVILVINKIDLV-KKEELLPLLAEYSELLDFA-E 144
|
170 180
....*....|....*....|....*
gi 15599762 311 VYVISALERDGTEALSQDIMRYLDE 335
Cdd:COG1159 145 IVPISALKGDNVDELLDEIAKLLPE 169
|
|
| NOG |
cd01897 |
Nucleolar GTP-binding protein (NOG); NOG1 is a nucleolar GTP-binding protein present in ... |
166-217 |
3.39e-10 |
|
Nucleolar GTP-binding protein (NOG); NOG1 is a nucleolar GTP-binding protein present in eukaryotes ranging from trypanosomes to humans. NOG1 is functionally linked to ribosome biogenesis and found in association with the nuclear pore complexes and identified in many preribosomal complexes. Thus, defects in NOG1 can lead to defects in 60S biogenesis. The S. cerevisiae NOG1 gene is essential for cell viability, and mutations in the predicted G motifs abrogate function. It is a member of the ODN family of GTP-binding proteins that also includes the bacterial Obg and DRG proteins.
Pssm-ID: 206684 [Multi-domain] Cd Length: 167 Bit Score: 58.34 E-value: 3.39e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 15599762 166 GLPNAGKSTFIRAVSAAKPKVADYPFTTLVPNLGVVSVGrYKSFVVADIPGL 217
Cdd:cd01897 7 GYPNVGKSSLVNKLTRAKPEVAPYPFTTKSLFVGHFDYK-YLRWQVIDTPGI 57
|
|
| era |
PRK00089 |
GTPase Era; Reviewed |
162-335 |
9.45e-10 |
|
GTPase Era; Reviewed
Pssm-ID: 234624 [Multi-domain] Cd Length: 292 Bit Score: 59.29 E-value: 9.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 162 VGLLGLPNAGKSTFIRA-----VSAAKPKvadyPFTTLVPNLGVVSVGRYKsFVVADIPGLIEgaAEGAgLGiRFLKHLA 236
Cdd:PRK00089 8 VAIVGRPNVGKSTLLNAlvgqkISIVSPK----PQTTRHRIRGIVTEDDAQ-IIFVDTPGIHK--PKRA-LN-RAMNKAA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 237 RTRI-----LLHLVD-MAPLDESDpadaaEVIVRELgrfspALTERERWLVLNKMDQILDPAEREARKQAVIERLGWEgP 310
Cdd:PRK00089 79 WSSLkdvdlVLFVVDaDEKIGPGD-----EFILEKL-----KKVKTPVILVLNKIDLVKDKEELLPLLEELSELMDFA-E 147
|
170 180
....*....|....*....|....*
gi 15599762 311 VYVISALERDGTEALSQDIMRYLDE 335
Cdd:PRK00089 148 IVPISALKGDNVDELLDVIAKYLPE 172
|
|
| HflX |
COG2262 |
50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis]; ... |
162-368 |
2.05e-09 |
|
50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441863 [Multi-domain] Cd Length: 419 Bit Score: 58.94 E-value: 2.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 162 VGLLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPNLGVVSVGRYKSFVVADIPGLIegaaegaglgiRFLKH------- 234
Cdd:COG2262 202 VALVGYTNAGKSTLFNRLTGADVLAEDKLFATLDPTTRRLELPDGRPVLLTDTVGFI-----------RKLPHqlveafr 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 235 --LARTR---ILLHLVDMapldeSDP-----ADAAEVIVRELGrfspaLTERERWLVLNKMDQiLDPAEREARKQavier 304
Cdd:COG2262 271 stLEEVReadLLLHVVDA-----SDPdfeeqIETVNEVLEELG-----ADDKPIILVFNKIDL-LDDEELERLRA----- 334
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 305 lGWEGPVYvISALERDGTEALSQDIMRYLDERTLRLE--------------------EDPQYAEELAELDRRIEDEARAR 364
Cdd:COG2262 335 -GYPDAVF-ISAKTGEGIDELLEAIEERLPEDRVEVElllpysdgdlvawlhehgevLSEEYDEDGTLLTVRLPPEDLAR 412
|
....
gi 15599762 365 LQAL 368
Cdd:COG2262 413 LEAY 416
|
|
| TIGR00092 |
TIGR00092 |
GTP-binding protein YchF; This predicted GTP-binding protein is found in a single copy in ... |
163-266 |
1.73e-08 |
|
GTP-binding protein YchF; This predicted GTP-binding protein is found in a single copy in every complete bacterial genome, and is found in Eukaryotes. A more distantly related protein, separated from this model, is found in the archaea. It is known to bind GTP and double-stranded nucleic acid. It is suggested to belong to a nucleoprotein complex and act as a translation factor. [Unknown function, General]
Pssm-ID: 129200 [Multi-domain] Cd Length: 368 Bit Score: 55.94 E-value: 1.73e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 163 GLLGLPNAGKSTFIRA-VSAAKPKVADYPFTTLVPNLGVVSV--------GRYKS--------FVVADIPGLIEGAAEGA 225
Cdd:TIGR00092 6 GIVGLPNVGKSTLFAAtTNLLGNEAANPPFTTIEPNAGVVNPsdprldllAIYIKpekvppttTEFVDIAGLVGGASKGE 85
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 15599762 226 GLGIRFLKHLARTRILLHLVDMAPLDES-------DPADAAEVIVREL 266
Cdd:TIGR00092 86 GLGNQFLANIREVDIIQHVVRCFEDDIIhhvgnvdDPRDDFEIIDEEL 133
|
|
| GTP_HflX |
TIGR03156 |
GTP-binding protein HflX; This protein family is one of a number of homologous small, ... |
162-333 |
3.83e-08 |
|
GTP-binding protein HflX; This protein family is one of a number of homologous small, well-conserved GTP-binding proteins with pleiotropic effects. Bacterial members are designated HflX, following the naming convention in Escherichia coli where HflX is encoded immediately downstream of the RNA chaperone Hfq, and immediately upstream of HflKC, a membrane-associated protease pair with an important housekeeping function. Over large numbers of other bacterial genomes, the pairing with hfq is more significant than with hflK and hlfC. The gene from Homo sapiens in this family has been named PGPL (pseudoautosomal GTP-binding protein-like). [Unknown function, General]
Pssm-ID: 274455 [Multi-domain] Cd Length: 351 Bit Score: 54.79 E-value: 3.83e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 162 VGLLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPNLGVVSVGRYKSFVVADIPGLiegaaegaglgIRFLKH------- 234
Cdd:TIGR03156 192 VALVGYTNAGKSTLFNALTGADVYAADQLFATLDPTTRRLDLPDGGEVLLTDTVGF-----------IRDLPHelvaafr 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 235 --LARTR---ILLHLVDMAPLDESDPADAAEVIVRELGrfspaLTERERWLVLNKMDQILDPAerearkqavIERLGWEG 309
Cdd:TIGR03156 261 atLEEVReadLLLHVVDASDPDREEQIEAVEKVLEELG-----AEDIPQLLVYNKIDLLDEPR---------IERLEEGY 326
|
170 180
....*....|....*....|....*
gi 15599762 310 PVYV-ISALERDGTEALSQDIMRYL 333
Cdd:TIGR03156 327 PEAVfVSAKTGEGLDLLLEAIAERL 351
|
|
| PRK11058 |
PRK11058 |
GTPase HflX; Provisional |
162-340 |
4.58e-08 |
|
GTPase HflX; Provisional
Pssm-ID: 182934 [Multi-domain] Cd Length: 426 Bit Score: 54.72 E-value: 4.58e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 162 VGLLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPNLGVVSVGRYKSFVVADIPGLiegaaegaglgIRFLKH------- 234
Cdd:PRK11058 200 VSLVGYTNAGKSTLFNRITEARVYAADQLFATLDPTLRRIDVADVGETVLADTVGF-----------IRHLPHdlvaafk 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 235 --LARTR---ILLHLVDMAPLDESDPADAAEVIVRELGRFS-PALtererwLVLNKMDQILDPAEREARKQAVIERLGWe 308
Cdd:PRK11058 269 atLQETRqatLLLHVVDAADVRVQENIEAVNTVLEEIDAHEiPTL------LVMNKIDMLDDFEPRIDRDEENKPIRVW- 341
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 15599762 309 gpvyvISALERDG--------TEALSQDIMRYlderTLRL 340
Cdd:PRK11058 342 -----LSAQTGAGipllfqalTERLSGEVAQH----TLRL 372
|
|
| era |
TIGR00436 |
GTP-binding protein Era; Era is an essential GTPase in Escherichia coli and many other ... |
162-343 |
1.19e-07 |
|
GTP-binding protein Era; Era is an essential GTPase in Escherichia coli and many other bacteria. It plays a role in ribosome biogenesis. Few bacteria lack this protein. [Protein synthesis, Other]
Pssm-ID: 129528 [Multi-domain] Cd Length: 270 Bit Score: 52.78 E-value: 1.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 162 VGLLGLPNAGKSTFIRAVSAAKPK-VADYPFTTLVPNLGVVSVGRYKSFVVaDIPGLIEgaaEGAGLGiRFLKHLARTRI 240
Cdd:TIGR00436 3 VAILGRPNVGKSTLLNQLHGQKISiTSPKAQTTRNRISGIHTTGASQIIFI-DTPGFHE---KKHSLN-RLMMKEARSAI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 241 -----LLHLVDMaplDESDPADaaEVIVRELGRfspalTERERWLVLNKMDQIL-DPAEREARKQAVIERLgweGPVYVI 314
Cdd:TIGR00436 78 ggvdlILFVVDS---DQWNGDG--EFVLTKLQN-----LKRPVVLTRNKLDNKFkDKLLPLIDKYAILEDF---KDIVPI 144
|
170 180
....*....|....*....|....*....
gi 15599762 315 SALERDGTEALSQDIMRYLDERTLRLEED 343
Cdd:TIGR00436 145 SALTGDNTSFLAAFIEVHLPEGPFRYPED 173
|
|
| PRK04213 |
PRK04213 |
GTP-binding protein EngB; |
157-336 |
2.45e-05 |
|
GTP-binding protein EngB;
Pssm-ID: 179790 [Multi-domain] Cd Length: 201 Bit Score: 44.91 E-value: 2.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 157 KVLADVGLLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPNlgvvSVgRYKSFVVADIPGL--IEGAAEGAGLGI----- 229
Cdd:PRK04213 7 DRKPEIVFVGRSNVGKSTLVRELTGKKVRVGKRPGVTRKPN----HY-DWGDFILTDLPGFgfMSGVPKEVQEKIkdeiv 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 230 RFLKHLARtRILL--HLVDmapldesdpADAA-EVIVR-----------ELGRFspaLTERE--RWLVLNKMDQILDpae 293
Cdd:PRK04213 82 RYIEDNAD-RILAavLVVD---------GKSFiEIIERwegrgeipidvEMFDF---LRELGipPIVAVNKMDKIKN--- 145
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 15599762 294 REARKQAVIERLG-------WEGPVYVISAlERDGTEALSQDIMRYLDER 336
Cdd:PRK04213 146 RDEVLDEIAERLGlyppwrqWQDIIAPISA-KKGGIEELKEAIRKRLHEA 194
|
|
| FeoB |
cd01879 |
Ferrous iron transport protein B (FeoB) family; Ferrous iron transport protein B (FeoB) ... |
164-334 |
1.07e-04 |
|
Ferrous iron transport protein B (FeoB) family; Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N terminus contains a P-loop motif suggesting that iron transport may be ATP dependent.
Pssm-ID: 206667 [Multi-domain] Cd Length: 159 Bit Score: 42.44 E-value: 1.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 164 LLGLPNAGKSTFIRAVSAAKPKVADYPFTTlvpnlgV-VSVGRYK----SFVVADIPGL--IEGAAEGAGLGIRFLKHlA 236
Cdd:cd01879 2 LVGNPNVGKTTLFNALTGARQKVGNWPGVT------VeKKEGEFKlggkEIEIVDLPGTysLTPYSEDEKVARDFLLG-E 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 237 RTRILLHLVDMAPLDESDPAdAAEVIvrELGRfsPALtererwLVLNKMDqildpaerEARKQAVI-------ERLGWeg 309
Cdd:cd01879 75 EPDLIVNVVDATNLERNLYL-TLQLL--ELGL--PVV------VALNMID--------EAEKRGIKidldklsELLGV-- 133
|
170 180
....*....|....*....|....*
gi 15599762 310 PVYVISALERDGTEALSQDIMRYLD 334
Cdd:cd01879 134 PVVPTSARKGEGIDELLDAIAKLAE 158
|
|
| YihA_EngB |
cd01876 |
YihA (EngB) GTPase family; The YihA (EngB) subfamily of GTPases is typified by the E. coli ... |
162-329 |
4.89e-04 |
|
YihA (EngB) GTPase family; The YihA (EngB) subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and consists of the GTPase domain only (some of the eukaryotic homologs contain an N-terminal extension of about 120 residues that might be involved in organellar targeting). Homologs of yihA are found in most Gram-positive and Gram-negative pathogenic bacteria, with the exception of Mycobacterium tuberculosis. The broad-spectrum nature of YihA and its essentiality for cell viability in bacteria make it an attractive antibacterial target.
Pssm-ID: 206665 [Multi-domain] Cd Length: 170 Bit Score: 40.57 E-value: 4.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 162 VGLLGLPNAGKSTFIRAVSAAK--PKVADYPFTTLVPNLgvVSVGryKSFVVADIPGLI------EGAAEGAGLGIRFLK 233
Cdd:cd01876 2 VAFAGRSNVGKSSLINALTNRKklARTSKTPGRTQLINF--FNVG--DKFRLVDLPGYGyakvskEVREKWGKLIEEYLE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 234 HLARTRILLHLVDM-APLDESDpADAAEVIVRELGRFSpaltererwLVLNKMDQiLDPAEREARKQAVIERLG---WEG 309
Cdd:cd01876 78 NRENLKGVVLLIDArHGPTPID-LEMLEFLEELGIPFL---------IVLTKADK-LKKSELAKVLKKIKEELNlfnILP 146
|
170 180
....*....|....*....|
gi 15599762 310 PVYVISALERDGTEALSQDI 329
Cdd:cd01876 147 PVILFSSKKGTGIDELRALI 166
|
|
| small_GTP |
TIGR00231 |
small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this ... |
162-331 |
8.31e-04 |
|
small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this model include Ras, RhoA, Rab11, translation elongation factor G, translation initiation factor IF-2, tetratcycline resistance protein TetM, CDC42, Era, ADP-ribosylation factors, tdhF, and many others. In some proteins the domain occurs more than once.This model recognizes a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model. [Unknown function, General]
Pssm-ID: 272973 [Multi-domain] Cd Length: 162 Bit Score: 39.66 E-value: 8.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 162 VGLLGLPNAGKSTFIRAVSAAKP-KVADYPFTTLVPNLGVVSV-GRYKSFVVADIPGLIEGAAEGAGLGIRFLKHLARTR 239
Cdd:TIGR00231 4 IVIVGHPNVGKSTLLNSLLGNKGsITEYYPGTTRNYVTTVIEEdGKTYKFNLLDTAGQEDYDAIRRLYYPQVERSLRVFD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 240 ILLHLVDMapldESDPADAAEVIVRELGRFSPALtererwLVLNKMDQI---LDPAEREarkqaVIERLGWEgPVYVISA 316
Cdd:TIGR00231 84 IVILVLDV----EEILEKQTKEIIHHADSGVPII------LVGNKIDLKdadLKTHVAS-----EFAKLNGE-PIIPLSA 147
|
170
....*....|....*
gi 15599762 317 LERDGTEALsQDIMR 331
Cdd:TIGR00231 148 ETGKNIDSA-FKIVE 161
|
|
| V-ATPase_G_2 |
pfam16999 |
Vacuolar (H+)-ATPase G subunit; This family represents vacuolar (H+)-ATPase G subunit from ... |
273-378 |
8.39e-04 |
|
Vacuolar (H+)-ATPase G subunit; This family represents vacuolar (H+)-ATPase G subunit from several bacterial and archaeal species. Subunit G is a component of the peripheral stalk of the ATPase complex
Pssm-ID: 339878 [Multi-domain] Cd Length: 104 Bit Score: 38.57 E-value: 8.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 273 LTERERWLvlnkmDQILDPAEREARkqAVIERlgwegpvyvisalerdgTEALSQDIMRYLDERTLRLEEdpQYAEELAE 352
Cdd:pfam16999 10 LAEREAAL-----DQQIEAARKEAE--REVEA-----------------AEAEAARILREAEAKAKALQA--EYRQELAA 63
|
90 100
....*....|....*....|....*.
gi 15599762 353 LDRRIEDEARARLQAldDARALRRSG 378
Cdd:pfam16999 64 ETARIREEARARAEA--EAQAVRTRA 87
|
|
| YjeQ_EngC |
cd01854 |
Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; ... |
280-337 |
1.22e-03 |
|
Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; YjeQ (YloQ in Bacillus subtilis) is a ribosomal small subunit-dependent GTPase; hence also known as RsgA. YjeQ is a late-stage ribosomal biogenesis factor involved in the 30S subunit maturation, and it represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. All YjeQ family proteins display a unique domain architecture, which includes an N-terminal OB-fold RNA-binding domain, the central permuted GTPase domain, and a zinc knuckle-like C-terminal cysteine domain.
Pssm-ID: 206747 [Multi-domain] Cd Length: 211 Bit Score: 40.07 E-value: 1.22e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 15599762 280 LVLNKMDqiLDPAEREARKQAVIERLGweGPVYVISALERDGTEALsqdiMRYLDERT 337
Cdd:cd01854 38 IVLNKAD--LVDDEELEELLEIYEKLG--YPVLAVSAKTGEGLDEL----RELLKGKT 87
|
|
| trmE |
PRK05291 |
tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE; |
164-344 |
4.07e-03 |
|
tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE;
Pssm-ID: 235392 [Multi-domain] Cd Length: 449 Bit Score: 39.32 E-value: 4.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 164 LLGLPNAGKSTFI-------RAVsaakpkVADYPFTTlvpnlgvvsvgR---YKSFVVADIP-------GLIEGAAEGAG 226
Cdd:PRK05291 220 IAGRPNVGKSSLLnallgeeRAI------VTDIAGTT-----------RdviEEHINLDGIPlrlidtaGIRETDDEVEK 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 227 LGI-RFLKHLARTRILLHLVDMAPLDESDPADAAEvivrelgrfspALTERERWLVLNKMDQILDPAEREARKQAVIErl 305
Cdd:PRK05291 283 IGIeRSREAIEEADLVLLVLDASEPLTEEDDEILE-----------ELKDKPVIVVLNKADLTGEIDLEEENGKPVIR-- 349
|
170 180 190
....*....|....*....|....*....|....*....
gi 15599762 306 gwegpvyvISALERDGTEALSQDIMRYLDERTLRLEEDP 344
Cdd:PRK05291 350 --------ISAKTGEGIDELREAIKELAFGGFGGNQEGV 380
|
|
| MnmE |
COG0486 |
tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE [Translation, ribosomal ... |
164-342 |
4.44e-03 |
|
tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE [Translation, ribosomal structure and biogenesis]; tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 440253 [Multi-domain] Cd Length: 448 Bit Score: 38.89 E-value: 4.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 164 LLGLPNAGKSTFIRAVSaakpkvadypfttlvpnlgvvsvGRYKSfVVADIPG----LIEGAA--EG--------AGL-- 227
Cdd:COG0486 218 IVGRPNVGKSSLLNALL-----------------------GEERA-IVTDIAGttrdVIEERIniGGipvrlidtAGLre 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599762 228 --------GIRF-LKHLARTRILLHLVDM-APLDESDPADAAEvivrelgrfspaLTERERWLVLNKMDQILDPAERear 297
Cdd:COG0486 274 tedevekiGIERaREAIEEADLVLLLLDAsEPLTEEDEEILEK------------LKDKPVIVVLNKIDLPSEADGE--- 338
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 15599762 298 kqavIERLGWEGPVYvISALERDGTEALSQDIMRYLDERTLRLEE 342
Cdd:COG0486 339 ----LKSLPGEPVIA-ISAKTGEGIDELKEAILELVGEGALEGEG 378
|
|
| RsgA_GTPase |
pfam03193 |
RsgA GTPase; RsgA (also known as EngC and YjeQ) represents a protein family whose members are ... |
280-337 |
8.39e-03 |
|
RsgA GTPase; RsgA (also known as EngC and YjeQ) represents a protein family whose members are broadly conserved in bacteria and are indispensable for growth. The GTPase domain of RsgA is very similar to several P-loop GTPases, but differs in having a circular permutation of the GTPase structure described by a G4-G1-G3 pattern.
Pssm-ID: 427191 [Multi-domain] Cd Length: 174 Bit Score: 37.14 E-value: 8.39e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 15599762 280 LVLNKMDqILDPAEREARKQAVIERLGWegPVYVISALERDGTEALsqdiMRYLDERT 337
Cdd:pfam03193 58 IVLNKID-LLDEEEELEELLKIYRAIGY--PVLFVSAKTGEGIEAL----KELLKGKT 108
|
|
| |
