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Conserved domains on  [gi|15599796|ref|NP_253290|]
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transcriptional regulator NfxB [Pseudomonas aeruginosa PAO1]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442015)

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.10.60|1.10.357.10
Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  23602932
SCOP:  4000333

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
8-154 8.04e-07

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 46.82  E-value: 8.04e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599796   8 ERLIKALAVAIVDRP--RATLKELAEAAGVSKATLHRFCGTRDNLVQ-MLEDHGETVLNQIIQAcdLEHAEPLEALQRLI 84
Cdd:COG1309   9 ERILDAALELFAEKGyeGTSVRDIAARAGVSKGTLYRHFGSKEELLLaVLERLLEELLAALEEA--LAAEDPRERLRALL 86

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599796  85 KEHLTHRELLVFLVFQYRPDFLDPHGEGARWQSYLEALDAFFLRGQQKGVFRIDITAAVFTELFITLVYG 154
Cdd:COG1309  87 RAYLEFLAENPALARLLLAEAAELPELRAALRALLRRLRALLAELLRAGGLLADVDPDALARALLALLDG 156
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
8-154 8.04e-07

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 46.82  E-value: 8.04e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599796   8 ERLIKALAVAIVDRP--RATLKELAEAAGVSKATLHRFCGTRDNLVQ-MLEDHGETVLNQIIQAcdLEHAEPLEALQRLI 84
Cdd:COG1309   9 ERILDAALELFAEKGyeGTSVRDIAARAGVSKGTLYRHFGSKEELLLaVLERLLEELLAALEEA--LAAEDPRERLRALL 86

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599796  85 KEHLTHRELLVFLVFQYRPDFLDPHGEGARWQSYLEALDAFFLRGQQKGVFRIDITAAVFTELFITLVYG 154
Cdd:COG1309  87 RAYLEFLAENPALARLLLAEAAELPELRAALRALLRRLRALLAELLRAGGLLADVDPDALARALLALLDG 156
HTH_10 pfam04967
HTH DNA binding domain;
8-41 1.41e-03

HTH DNA binding domain;


Pssm-ID: 282780 [Multi-domain]  Cd Length: 53  Bit Score: 35.28  E-value: 1.41e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 15599796     8 ERLIKALAVAIV----DRPR-ATLKELAEAAGVSKATLH 41
Cdd:pfam04967   3 DRQLEVLRLAYEmgyfDYPRrVTLKELAKELGISKSTLS 41
HTH_LACI smart00354
helix_turn _helix lactose operon repressor;
24-58 4.57e-03

helix_turn _helix lactose operon repressor;


Pssm-ID: 197675 [Multi-domain]  Cd Length: 70  Bit Score: 34.49  E-value: 4.57e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 15599796     24 ATLKELAEAAGVSKATLHRFCG--------TRDNLVQMLEDHG 58
Cdd:smart00354   1 ATIKDVARLAGVSKATVSRVLNgkgrvseeTREKVLAAMEELG 43
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
8-154 8.04e-07

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 46.82  E-value: 8.04e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599796   8 ERLIKALAVAIVDRP--RATLKELAEAAGVSKATLHRFCGTRDNLVQ-MLEDHGETVLNQIIQAcdLEHAEPLEALQRLI 84
Cdd:COG1309   9 ERILDAALELFAEKGyeGTSVRDIAARAGVSKGTLYRHFGSKEELLLaVLERLLEELLAALEEA--LAAEDPRERLRALL 86

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599796  85 KEHLTHRELLVFLVFQYRPDFLDPHGEGARWQSYLEALDAFFLRGQQKGVFRIDITAAVFTELFITLVYG 154
Cdd:COG1309  87 RAYLEFLAENPALARLLLAEAAELPELRAALRALLRRLRALLAELLRAGGLLADVDPDALARALLALLDG 156
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
9-58 1.40e-03

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 38.26  E-value: 1.40e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 15599796   9 RLIKALAVAivdRPRATLKELAEAAGVSKATLHRfcgtrdnLVQMLEDHG 58
Cdd:COG1414  13 AILEALAEA---GGGLSLSELARRLGLPKSTVHR-------LLATLEEEG 52
HTH_10 pfam04967
HTH DNA binding domain;
8-41 1.41e-03

HTH DNA binding domain;


Pssm-ID: 282780 [Multi-domain]  Cd Length: 53  Bit Score: 35.28  E-value: 1.41e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 15599796     8 ERLIKALAVAIV----DRPR-ATLKELAEAAGVSKATLH 41
Cdd:pfam04967   3 DRQLEVLRLAYEmgyfDYPRrVTLKELAKELGISKSTLS 41
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 12-44 1.53e-03

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 37.98  E-value: 1.53e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 15599796  12 KALAVAIVDRPR----ATLKELAEAAGVSKATLHRFC 44
Cdd:COG1737  23 RRIADYILDNPEevafMSIAELAEAAGVSEATVVRFC 59
HTH_LACI smart00354
helix_turn _helix lactose operon repressor;
24-58 4.57e-03

helix_turn _helix lactose operon repressor;


Pssm-ID: 197675 [Multi-domain]  Cd Length: 70  Bit Score: 34.49  E-value: 4.57e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 15599796     24 ATLKELAEAAGVSKATLHRFCG--------TRDNLVQMLEDHG 58
Cdd:smart00354   1 ATIKDVARLAGVSKATVSRVLNgkgrvseeTREKVLAAMEELG 43
HTH_IclR pfam09339
IclR helix-turn-helix domain;
9-58 8.49e-03

IclR helix-turn-helix domain;


Pssm-ID: 430539 [Multi-domain]  Cd Length: 52  Bit Score: 33.15  E-value: 8.49e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 15599796     9 RLIKALAVAivdRPRATLKELAEAAGVSKATLHRfcgtrdnLVQMLEDHG 58
Cdd:pfam09339   7 AILDALAEA---PGPLTLTEIARRTGLPKSTAHR-------LLQTLVELG 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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