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Conserved domains on  [gi|15600440|ref|NP_253934|]
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hypothetical protein PA5247 [Pseudomonas aeruginosa PAO1]

Protein Classification

DUF188 domain-containing protein( domain architecture ID 10004144)

uncharacterized DUF188 domain-containing protein similar to Escherichia coli YaiI

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YaiI COG1671
Uncharacterized conserved protein YaiI, UPF0178 family [Function unknown];
1-150 4.79e-71

Uncharacterized conserved protein YaiI, UPF0178 family [Function unknown];


:

Pssm-ID: 441277  Cd Length: 149  Bit Score: 210.73  E-value: 4.79e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600440   1 MRIWIDADACPKAaKELVCKFALKRKLEVWMVAGQPQVKPPFACVRLVVVESGMDAADDYLVEQAEPGDLAICSDVPLAD 80
Cdd:COG1671   1 MKIWVDADACPVV-KEIIFRVAERYGIPVTLVANQSHRIPPSPYIETVVVDAGFDAADDYIVNRAEPGDLVITQDIPLAA 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600440  81 RLIKKQVAALDPRGREFDARNMGDKLAMRNLMADLRDQGQMGGGQAPYGERDRQAFANALDRLLTRLQRE 150
Cdd:COG1671  80 RVLEKGALVLNPRGELYTEENIGELLAMRDLMAKLRRSGGRTGGPKPFSKEDRQRFANALDRLLARAKRR 149
 
Name Accession Description Interval E-value
YaiI COG1671
Uncharacterized conserved protein YaiI, UPF0178 family [Function unknown];
1-150 4.79e-71

Uncharacterized conserved protein YaiI, UPF0178 family [Function unknown];


Pssm-ID: 441277  Cd Length: 149  Bit Score: 210.73  E-value: 4.79e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600440   1 MRIWIDADACPKAaKELVCKFALKRKLEVWMVAGQPQVKPPFACVRLVVVESGMDAADDYLVEQAEPGDLAICSDVPLAD 80
Cdd:COG1671   1 MKIWVDADACPVV-KEIIFRVAERYGIPVTLVANQSHRIPPSPYIETVVVDAGFDAADDYIVNRAEPGDLVITQDIPLAA 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600440  81 RLIKKQVAALDPRGREFDARNMGDKLAMRNLMADLRDQGQMGGGQAPYGERDRQAFANALDRLLTRLQRE 150
Cdd:COG1671  80 RVLEKGALVLNPRGELYTEENIGELLAMRDLMAKLRRSGGRTGGPKPFSKEDRQRFANALDRLLARAKRR 149
DUF188 pfam02639
Uncharacterized BCR, YaiI/YqxD family COG1671;
18-146 4.12e-58

Uncharacterized BCR, YaiI/YqxD family COG1671;


Pssm-ID: 426896  Cd Length: 130  Bit Score: 177.28  E-value: 4.12e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600440    18 VCKFALKRKLEVWMVAGQPQVKPPFACVRLVVVESGMDAADDYLVEQAEPGDLAICSDVPLADRLIKKQVAALDPRGREF 97
Cdd:pfam02639   2 IFRVAERHGIPVTLVANQNHRVPSSPLIETVVVDAGFDAADDYIAELAEPGDLVITQDIPLAARVLGKGAYVLNPRGELY 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 15600440    98 DARNMGDKLAMRNLMADLRDQGQMGGGQAPYGERDRQAFANALDRLLTR 146
Cdd:pfam02639  82 TEENIGELLAMRDLMAKLRRAGGRTGGPKPFSKEDRSRFANALDRLLAR 130
PRK00124 PRK00124
YaiI/YqxD family protein;
1-150 3.83e-50

YaiI/YqxD family protein;


Pssm-ID: 178882 [Multi-domain]  Cd Length: 151  Bit Score: 157.72  E-value: 3.83e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600440    1 MRIWIDADACPkaAKELVCKFALKRKLEVWMVAGQ----PQVKPPFacVRLVVVESGMDAADDYLVEQAEPGDLAICSDV 76
Cdd:PRK00124   1 MKIYVDADACP--VKDIIIRVAERHGIPVTLVASFnhflRVPYSPF--IRTVYVDAGFDAADNEIVQLAEKGDIVITQDY 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15600440   77 PLADRLIKKQVAALDPRGREFDARNMGDKLAMRNLMADLRDQGQMGGGQAPYGERDRQAFANALDRLLTRLQRE 150
Cdd:PRK00124  77 GLAALALEKGAIVLNPRGYIYTNDNIDQLLAMRDLMATLRRSGIRTGGPKPFTQEDRSRFEAELDKLIRRIKRL 150
PIN_YqxD-like cd18720
LabA-like PIN domain of uncharacterized Bacillus subtilis YqxD and related proteins; This ...
 2-97 1.45e-44

LabA-like PIN domain of uncharacterized Bacillus subtilis YqxD and related proteins; This subfamily includes the PIN domain of uncharacterized Bacillus subtilis YqxD (also known as YqfM) and Escherichia coli YaiI. Firmicute, such as Bacillus and Listeria, YqxD proteins are encoded within RNA polymerase major sigma43 operons, whereas E. coli YaiL is transcribed as a mono cistron. This subfamily belongs to LabA-like PIN domain family which includes Synechococcus elongatus PCC 7942 LabA, human ZNF451, uncharacterized Bacillus subtilis YqxD and Escherichia coli YaiI, and the N-terminal domain of a well-conserved group of mainly bacterial proteins with no defined function, which contain a C-terminal LabA_like_C domain. Curiously, a gene labeled NicB from Pseudomonas putida S16, which is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine also falls into the LabA-like PIN family. The PIN (PilT N terminus) domain belongs to a large nuclease superfamily. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.


Pssm-ID: 350287  Cd Length: 96  Bit Score: 141.84  E-value: 1.45e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600440   2 RIWIDADACPKAAKELVCKFALKRKLEVWMVAGQPQVKPPFACVRLVVVESGMDAADDYLVEQAEPGDLAICSDVPLADR 81
Cdd:cd18720   1 KIWVDADACPVKIKEILFRAAERLQIPVIFVANQPLRLPPSPLIRWIVVDSGFDAADDYIVEHVEPGDLVITADIPLAAL 80

                        90
                ....*....|....*.
gi 15600440  82 LIKKQVAALDPRGREF 97
Cdd:cd18720  81 VVEKGAYVLNPRGELY 96
 
Name Accession Description Interval E-value
YaiI COG1671
Uncharacterized conserved protein YaiI, UPF0178 family [Function unknown];
1-150 4.79e-71

Uncharacterized conserved protein YaiI, UPF0178 family [Function unknown];


Pssm-ID: 441277  Cd Length: 149  Bit Score: 210.73  E-value: 4.79e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600440   1 MRIWIDADACPKAaKELVCKFALKRKLEVWMVAGQPQVKPPFACVRLVVVESGMDAADDYLVEQAEPGDLAICSDVPLAD 80
Cdd:COG1671   1 MKIWVDADACPVV-KEIIFRVAERYGIPVTLVANQSHRIPPSPYIETVVVDAGFDAADDYIVNRAEPGDLVITQDIPLAA 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600440  81 RLIKKQVAALDPRGREFDARNMGDKLAMRNLMADLRDQGQMGGGQAPYGERDRQAFANALDRLLTRLQRE 150
Cdd:COG1671  80 RVLEKGALVLNPRGELYTEENIGELLAMRDLMAKLRRSGGRTGGPKPFSKEDRQRFANALDRLLARAKRR 149
DUF188 pfam02639
Uncharacterized BCR, YaiI/YqxD family COG1671;
18-146 4.12e-58

Uncharacterized BCR, YaiI/YqxD family COG1671;


Pssm-ID: 426896  Cd Length: 130  Bit Score: 177.28  E-value: 4.12e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600440    18 VCKFALKRKLEVWMVAGQPQVKPPFACVRLVVVESGMDAADDYLVEQAEPGDLAICSDVPLADRLIKKQVAALDPRGREF 97
Cdd:pfam02639   2 IFRVAERHGIPVTLVANQNHRVPSSPLIETVVVDAGFDAADDYIAELAEPGDLVITQDIPLAARVLGKGAYVLNPRGELY 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 15600440    98 DARNMGDKLAMRNLMADLRDQGQMGGGQAPYGERDRQAFANALDRLLTR 146
Cdd:pfam02639  82 TEENIGELLAMRDLMAKLRRAGGRTGGPKPFSKEDRSRFANALDRLLAR 130
PRK00124 PRK00124
YaiI/YqxD family protein;
1-150 3.83e-50

YaiI/YqxD family protein;


Pssm-ID: 178882 [Multi-domain]  Cd Length: 151  Bit Score: 157.72  E-value: 3.83e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600440    1 MRIWIDADACPkaAKELVCKFALKRKLEVWMVAGQ----PQVKPPFacVRLVVVESGMDAADDYLVEQAEPGDLAICSDV 76
Cdd:PRK00124   1 MKIYVDADACP--VKDIIIRVAERHGIPVTLVASFnhflRVPYSPF--IRTVYVDAGFDAADNEIVQLAEKGDIVITQDY 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15600440   77 PLADRLIKKQVAALDPRGREFDARNMGDKLAMRNLMADLRDQGQMGGGQAPYGERDRQAFANALDRLLTRLQRE 150
Cdd:PRK00124  77 GLAALALEKGAIVLNPRGYIYTNDNIDQLLAMRDLMATLRRSGIRTGGPKPFTQEDRSRFEAELDKLIRRIKRL 150
PIN_YqxD-like cd18720
LabA-like PIN domain of uncharacterized Bacillus subtilis YqxD and related proteins; This ...
 2-97 1.45e-44

LabA-like PIN domain of uncharacterized Bacillus subtilis YqxD and related proteins; This subfamily includes the PIN domain of uncharacterized Bacillus subtilis YqxD (also known as YqfM) and Escherichia coli YaiI. Firmicute, such as Bacillus and Listeria, YqxD proteins are encoded within RNA polymerase major sigma43 operons, whereas E. coli YaiL is transcribed as a mono cistron. This subfamily belongs to LabA-like PIN domain family which includes Synechococcus elongatus PCC 7942 LabA, human ZNF451, uncharacterized Bacillus subtilis YqxD and Escherichia coli YaiI, and the N-terminal domain of a well-conserved group of mainly bacterial proteins with no defined function, which contain a C-terminal LabA_like_C domain. Curiously, a gene labeled NicB from Pseudomonas putida S16, which is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine also falls into the LabA-like PIN family. The PIN (PilT N terminus) domain belongs to a large nuclease superfamily. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.


Pssm-ID: 350287  Cd Length: 96  Bit Score: 141.84  E-value: 1.45e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600440   2 RIWIDADACPKAAKELVCKFALKRKLEVWMVAGQPQVKPPFACVRLVVVESGMDAADDYLVEQAEPGDLAICSDVPLADR 81
Cdd:cd18720   1 KIWVDADACPVKIKEILFRAAERLQIPVIFVANQPLRLPPSPLIRWIVVDSGFDAADDYIVEHVEPGDLVITADIPLAAL 80

                        90
                ....*....|....*.
gi 15600440  82 LIKKQVAALDPRGREF 97
Cdd:cd18720  81 VVEKGAYVLNPRGELY 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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