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Conserved domains on  [gi|148747499|ref|NP_291065|]
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protocadherin gamma-A4 precursor [Mus musculus]

Protein Classification

protocadherin( domain architecture ID 11175791)

protocadherin may have tightly regulated functions in the development, regionalization, and functional differentiation of the central nervous system

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 29-111 7.23e-41

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 144.59  E-value: 7.23e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499   29 QIRYSVPEELERGSVVGNLAADLGLEPGKLAERGVRIVSRGKTQLFALNPRSGSLVTAGRVDREGLCDRSPKCTANLEIL 108
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 148747499  109 LED 111
Cdd:pfam08266  81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 245-342 2.58e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.80  E-value: 2.58e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499 245 EYHISVKENLPVGTRLLTIKATDPDEGVNGEVTYSFrnVREKISQLFQLNSLTGDITVLGELDYEDSGFYDVDVEAHDG- 323
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGg 78

                         90       100
                 ....*....|....*....|
gi 148747499 324 -PGLRARSKVLVTVLDVNDN 342
Cdd:cd11304   79 gPPLSSTATVTITVLDVNDN 98
Cadherin_tail super family cl24520
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 809-903 1.13e-30

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


The actual alignment was detected with superfamily member pfam15974:

Pssm-ID: 435046  Cd Length: 134  Bit Score: 117.43  E-value: 1.13e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499  809 PPNTDWRFSQAQRPGTSGS-QNGDETGTWPNNQFDTEMLQAMIlASASEAADGSSTL---GGGAGTMGLSARYGPQFTLQ 884
Cdd:pfam15974   2 PPNPDWRYSASLRAGPMQSsVHMEEAGVLRGGPGGLEQQWPTV-SSATPEPEAGEVSppvGAGVNSNSWTFRYGPGNPKQ 80

                          90       100
                  ....*....|....*....|
gi 148747499  885 HVPD-YRQNVYIPGSNATLT 903
Cdd:pfam15974  81 PVPGeYPENFIIPGSPAIIS 100
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 687-771 1.14e-30

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


:

Pssm-ID: 465139  Cd Length: 84  Bit Score: 115.70  E-value: 1.14e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499  687 DITLYLVVAVAAVSCVFLAFVIVLLIHRLRRWHSTRLLQAAGNgLSSLPASHFVGVDGVHAFLQTYSHEVSLTADSGKSH 766
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSSGN-LCSVPAPHFPGNDGTGTLPQSYSYEVCLTSDSGKSE 79


                  ....*
gi 148747499  767 LIFPQ 771
Cdd:pfam16492  80 FKFLK 84
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 354-447 1.16e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.62  E-value: 1.16e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499 354 SIQEASSPGTVIALFNVHDSDSGENGLVTCSI---PDNLPFRLEKTYGNyhrLLIHRTLDREEVSDYNITITATDQGTPP 430
Cdd:cd11304    5 SVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSIDPSTGE---ITTAKPLDREEQSSYTLTVTATDGGGPP 81

                         90
                 ....*....|....*..
gi 148747499 431 LSTETYISLQVVDINDN 447
Cdd:cd11304   82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 138-237 5.24e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.00  E-value: 5.24e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499 138 EIKVAESENPGTRFPLPEAFDLDIGVNALQGYQLSSND---HFSLDVQSGpdgikypELVLENALDREEEAVHHLVLTAF 214
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNedgLFSIDPSTG-------EITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|...
gi 148747499 215 DGGDPVRSGTATIQVTLVDTNDN 237
Cdd:cd11304   76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 578-665 7.36e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 96.61  E-value: 7.36e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499 578 PRSADPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-SLVVTVQDHGQPPLSAT 656
Cdd:cd11304    7 PENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKP-LDREEQSSyTLTVTATDGGGPPLSST 85


                 ....*....
gi 148747499 657 VTLTIAVSD 665
Cdd:cd11304   86 ATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 455-557 2.25e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.07  E-value: 2.25e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499 455 SYSAYIPENNPRGASILSITAQDPDSGENAQVIYSLSEDTIQGapmssYVSINSNTGVLYALRSFDYEQFQDLKLLVTAR 534
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-----LFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|...
gi 148747499 535 DSGTPPLSSNVSLSLSVLDQNDN 557
Cdd:cd11304   76 DGGGPPLSSTATVTITVLDVNDN 98
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 29-111 7.23e-41

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 144.59  E-value: 7.23e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499   29 QIRYSVPEELERGSVVGNLAADLGLEPGKLAERGVRIVSRGKTQLFALNPRSGSLVTAGRVDREGLCDRSPKCTANLEIL 108
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 148747499  109 LED 111
Cdd:pfam08266  81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 245-342 2.58e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.80  E-value: 2.58e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499 245 EYHISVKENLPVGTRLLTIKATDPDEGVNGEVTYSFrnVREKISQLFQLNSLTGDITVLGELDYEDSGFYDVDVEAHDG- 323
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGg 78

                         90       100
                 ....*....|....*....|
gi 148747499 324 -PGLRARSKVLVTVLDVNDN 342
Cdd:cd11304   79 gPPLSSTATVTITVLDVNDN 98
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 809-903 1.13e-30

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


Pssm-ID: 435046  Cd Length: 134  Bit Score: 117.43  E-value: 1.13e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499  809 PPNTDWRFSQAQRPGTSGS-QNGDETGTWPNNQFDTEMLQAMIlASASEAADGSSTL---GGGAGTMGLSARYGPQFTLQ 884
Cdd:pfam15974   2 PPNPDWRYSASLRAGPMQSsVHMEEAGVLRGGPGGLEQQWPTV-SSATPEPEAGEVSppvGAGVNSNSWTFRYGPGNPKQ 80

                          90       100
                  ....*....|....*....|
gi 148747499  885 HVPD-YRQNVYIPGSNATLT 903
Cdd:pfam15974  81 PVPGeYPENFIIPGSPAIIS 100
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 687-771 1.14e-30

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 115.70  E-value: 1.14e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499  687 DITLYLVVAVAAVSCVFLAFVIVLLIHRLRRWHSTRLLQAAGNgLSSLPASHFVGVDGVHAFLQTYSHEVSLTADSGKSH 766
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSSGN-LCSVPAPHFPGNDGTGTLPQSYSYEVCLTSDSGKSE 79


                  ....*
gi 148747499  767 LIFPQ 771
Cdd:pfam16492  80 FKFLK 84
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 354-447 1.16e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.62  E-value: 1.16e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499 354 SIQEASSPGTVIALFNVHDSDSGENGLVTCSI---PDNLPFRLEKTYGNyhrLLIHRTLDREEVSDYNITITATDQGTPP 430
Cdd:cd11304    5 SVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSIDPSTGE---ITTAKPLDREEQSSYTLTVTATDGGGPP 81

                         90
                 ....*....|....*..
gi 148747499 431 LSTETYISLQVVDINDN 447
Cdd:cd11304   82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 138-237 5.24e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.00  E-value: 5.24e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499 138 EIKVAESENPGTRFPLPEAFDLDIGVNALQGYQLSSND---HFSLDVQSGpdgikypELVLENALDREEEAVHHLVLTAF 214
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNedgLFSIDPSTG-------EITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|...
gi 148747499 215 DGGDPVRSGTATIQVTLVDTNDN 237
Cdd:cd11304   76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 578-665 7.36e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 96.61  E-value: 7.36e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499 578 PRSADPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-SLVVTVQDHGQPPLSAT 656
Cdd:cd11304    7 PENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKP-LDREEQSSyTLTVTATDGGGPPLSST 85


                 ....*....
gi 148747499 657 VTLTIAVSD 665
Cdd:cd11304   86 ATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 455-557 2.25e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.07  E-value: 2.25e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499 455 SYSAYIPENNPRGASILSITAQDPDSGENAQVIYSLSEDTIQGapmssYVSINSNTGVLYALRSFDYEQFQDLKLLVTAR 534
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-----LFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|...
gi 148747499 535 DSGTPPLSSNVSLSLSVLDQNDN 557
Cdd:cd11304   76 DGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 369-449 5.63e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.79  E-value: 5.63e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499   369 NVHDSDSGENGLVTCSI---PDNLPFRLEKTYGnyhRLLIHRTLDREEVSDYNITITATDQGTPPLSTETYISLQVVDIN 445
Cdd:smart00112   1 SATDADSGENGKVTYSIlsgNDDGLFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 148747499   446 DNPP 449
Cdd:smart00112  78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 264-344 8.19e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.32  E-value: 8.19e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499   264 KATDPDEGVNGEVTYSFrnVREKISQLFQLNSLTGDITVLGELDYEDSGFYDVDVEA--HDGPGLRARSKVLVTVLDVND 341
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEAtdGGGPPLSSTATVTITVLDVND 78


                   ...
gi 148747499   342 NAP 344
Cdd:smart00112  79 NAP 81
Cadherin pfam00028
Cadherin domain;
246-337 1.06e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 84.66  E-value: 1.06e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499  246 YHISVKENLPVGTRLLTIKATDPDEGVNGEVTYSFrnVREKISQLFQLNSLTGDITVLGELDYEDSGFYDVDVEA--HDG 323
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI--LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEAtdSGG 78

                          90
                  ....*....|....
gi 148747499  324 PGLRARSKVLVTVL 337
Cdd:pfam00028  79 PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 591-680 1.29e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.24  E-value: 1.29e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499   591 VAVDKDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-SLVVTVQDHGQPPLSATVTLTIAVSDnipd 669
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKP-LDREEQPEyTLTVEATDGGGPPLSSTATVTITVLD---- 75

                           90
                   ....*....|.
gi 148747499   670 iladlVNINAP 680
Cdd:smart00112  76 -----VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 156-239 8.27e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.93  E-value: 8.27e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499   156 AFDLDIGVNALQGYQLSSND---HFSLDVQSGpdgikypELVLENALDREEEAVHHLVLTAFDGGDPVRSGTATIQVTLV 232
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNddgLFSIDPETG-------EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*..
gi 148747499   233 DTNDNAP 239
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
456-540 1.15e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.80  E-value: 1.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499  456 YSAYIPENNPRGASILSITAQDPDSGENAQVIYSLSEDtiqgaPMSSYVSINSNTGVLYALRSFDYEQFQDLKLLVTARD 535
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG-----GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD 75


                  ....*
gi 148747499  536 SGTPP 540
Cdd:pfam00028  76 SGGPP 80
Cadherin pfam00028
Cadherin domain;
578-663 4.35e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.56  E-value: 4.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499  578 PRSADPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-SLVVTVQDHGQPPLSAT 656
Cdd:pfam00028   6 PENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKP-LDRESIGEyELTVEATDSGGPPLSST 84


                  ....*..
gi 148747499  657 VTLTIAV 663
Cdd:pfam00028  85 ATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 474-559 5.44e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.84  E-value: 5.44e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499   474 TAQDPDSGENAQVIYSLSEDTIQGapmssYVSINSNTGVLYALRSFDYEQFQDLKLLVTARDSGTPPLSSNVSLSLSVLD 553
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDG-----LFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 148747499   554 QNDNTP 559
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
354-441 1.59e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.64  E-value: 1.59e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499  354 SIQEASSPGTVIALFNVHDSDSGENGLVTCSI---PDNLPFRLEKTYGnyhRLLIHRTLDREEVSDYNITITATDQGTPP 430
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlggGPGGNFRIDPDTG---DISTTKPLDRESIGEYELTVEATDSGGPP 80

                          90
                  ....*....|.
gi 148747499  431 LSTETYISLQV 441
Cdd:pfam00028  81 LSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
137-231 7.72e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 59.24  E-value: 7.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499  137 REIKVAESENPGTRFPLPEAFDLDIGVNALQGYQLSS---NDHFSLDVQSGpdgikypELVLENALDREEEAVHHLVLTA 213
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGggpGGNFRIDPDTG-------DISTTKPLDRESIGEYELTVEA 73

                          90
                  ....*....|....*...
gi 148747499  214 FDGGDPVRSGTATIQVTL 231
Cdd:pfam00028  74 TDSGGPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 29-128 2.91e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 55.01  E-value: 2.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499  29 QIRYSVPEELERGSVVGNL-AADLGLepGKLAERGVRIVSRGKTQLFALNPRSGSLVTAGRVDREglcdrsPKCTANLEI 107
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVsATDPDS--GENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE------EQSSYTLTV 72

                         90       100
                 ....*....|....*....|....*.
gi 148747499 108 LLEDKVRILA-----IEVEIIDVNDN 128
Cdd:cd11304   73 TATDGGGPPLsstatVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 64-130 6.34e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 42.34  E-value: 6.34e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148747499    64 RIVSRGKTQLFALNPRSGSLVTAGRVDREglcdrsPKCTANLEILLEDK-VRILA----IEVEIIDVNDNAP 130
Cdd:smart00112  16 SILSGNDDGLFSIDPETGEITTTKPLDRE------EQPEYTLTVEATDGgGPPLSstatVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 29-111 7.23e-41

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 144.59  E-value: 7.23e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499   29 QIRYSVPEELERGSVVGNLAADLGLEPGKLAERGVRIVSRGKTQLFALNPRSGSLVTAGRVDREGLCDRSPKCTANLEIL 108
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 148747499  109 LED 111
Cdd:pfam08266  81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 245-342 2.58e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.80  E-value: 2.58e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499 245 EYHISVKENLPVGTRLLTIKATDPDEGVNGEVTYSFrnVREKISQLFQLNSLTGDITVLGELDYEDSGFYDVDVEAHDG- 323
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGg 78

                         90       100
                 ....*....|....*....|
gi 148747499 324 -PGLRARSKVLVTVLDVNDN 342
Cdd:cd11304   79 gPPLSSTATVTITVLDVNDN 98
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 809-903 1.13e-30

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


Pssm-ID: 435046  Cd Length: 134  Bit Score: 117.43  E-value: 1.13e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499  809 PPNTDWRFSQAQRPGTSGS-QNGDETGTWPNNQFDTEMLQAMIlASASEAADGSSTL---GGGAGTMGLSARYGPQFTLQ 884
Cdd:pfam15974   2 PPNPDWRYSASLRAGPMQSsVHMEEAGVLRGGPGGLEQQWPTV-SSATPEPEAGEVSppvGAGVNSNSWTFRYGPGNPKQ 80

                          90       100
                  ....*....|....*....|
gi 148747499  885 HVPD-YRQNVYIPGSNATLT 903
Cdd:pfam15974  81 PVPGeYPENFIIPGSPAIIS 100
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 687-771 1.14e-30

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 115.70  E-value: 1.14e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499  687 DITLYLVVAVAAVSCVFLAFVIVLLIHRLRRWHSTRLLQAAGNgLSSLPASHFVGVDGVHAFLQTYSHEVSLTADSGKSH 766
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSSGN-LCSVPAPHFPGNDGTGTLPQSYSYEVCLTSDSGKSE 79


                  ....*
gi 148747499  767 LIFPQ 771
Cdd:pfam16492  80 FKFLK 84
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 354-447 1.16e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.62  E-value: 1.16e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499 354 SIQEASSPGTVIALFNVHDSDSGENGLVTCSI---PDNLPFRLEKTYGNyhrLLIHRTLDREEVSDYNITITATDQGTPP 430
Cdd:cd11304    5 SVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSIDPSTGE---ITTAKPLDREEQSSYTLTVTATDGGGPP 81

                         90
                 ....*....|....*..
gi 148747499 431 LSTETYISLQVVDINDN 447
Cdd:cd11304   82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 138-237 5.24e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.00  E-value: 5.24e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499 138 EIKVAESENPGTRFPLPEAFDLDIGVNALQGYQLSSND---HFSLDVQSGpdgikypELVLENALDREEEAVHHLVLTAF 214
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNedgLFSIDPSTG-------EITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|...
gi 148747499 215 DGGDPVRSGTATIQVTLVDTNDN 237
Cdd:cd11304   76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 578-665 7.36e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 96.61  E-value: 7.36e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499 578 PRSADPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-SLVVTVQDHGQPPLSAT 656
Cdd:cd11304    7 PENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKP-LDREEQSSyTLTVTATDGGGPPLSST 85


                 ....*....
gi 148747499 657 VTLTIAVSD 665
Cdd:cd11304   86 ATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 455-557 2.25e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.07  E-value: 2.25e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499 455 SYSAYIPENNPRGASILSITAQDPDSGENAQVIYSLSEDTIQGapmssYVSINSNTGVLYALRSFDYEQFQDLKLLVTAR 534
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-----LFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|...
gi 148747499 535 DSGTPPLSSNVSLSLSVLDQNDN 557
Cdd:cd11304   76 DGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 369-449 5.63e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.79  E-value: 5.63e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499   369 NVHDSDSGENGLVTCSI---PDNLPFRLEKTYGnyhRLLIHRTLDREEVSDYNITITATDQGTPPLSTETYISLQVVDIN 445
Cdd:smart00112   1 SATDADSGENGKVTYSIlsgNDDGLFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 148747499   446 DNPP 449
Cdd:smart00112  78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 264-344 8.19e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.32  E-value: 8.19e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499   264 KATDPDEGVNGEVTYSFrnVREKISQLFQLNSLTGDITVLGELDYEDSGFYDVDVEA--HDGPGLRARSKVLVTVLDVND 341
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEAtdGGGPPLSSTATVTITVLDVND 78


                   ...
gi 148747499   342 NAP 344
Cdd:smart00112  79 NAP 81
Cadherin pfam00028
Cadherin domain;
246-337 1.06e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 84.66  E-value: 1.06e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499  246 YHISVKENLPVGTRLLTIKATDPDEGVNGEVTYSFrnVREKISQLFQLNSLTGDITVLGELDYEDSGFYDVDVEA--HDG 323
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI--LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEAtdSGG 78

                          90
                  ....*....|....
gi 148747499  324 PGLRARSKVLVTVL 337
Cdd:pfam00028  79 PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 591-680 1.29e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.24  E-value: 1.29e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499   591 VAVDKDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-SLVVTVQDHGQPPLSATVTLTIAVSDnipd 669
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKP-LDREEQPEyTLTVEATDGGGPPLSSTATVTITVLD---- 75

                           90
                   ....*....|.
gi 148747499   670 iladlVNINAP 680
Cdd:smart00112  76 -----VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 156-239 8.27e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.93  E-value: 8.27e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499   156 AFDLDIGVNALQGYQLSSND---HFSLDVQSGpdgikypELVLENALDREEEAVHHLVLTAFDGGDPVRSGTATIQVTLV 232
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNddgLFSIDPETG-------EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*..
gi 148747499   233 DTNDNAP 239
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
456-540 1.15e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.80  E-value: 1.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499  456 YSAYIPENNPRGASILSITAQDPDSGENAQVIYSLSEDtiqgaPMSSYVSINSNTGVLYALRSFDYEQFQDLKLLVTARD 535
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG-----GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD 75


                  ....*
gi 148747499  536 SGTPP 540
Cdd:pfam00028  76 SGGPP 80
Cadherin pfam00028
Cadherin domain;
578-663 4.35e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.56  E-value: 4.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499  578 PRSADPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-SLVVTVQDHGQPPLSAT 656
Cdd:pfam00028   6 PENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKP-LDRESIGEyELTVEATDSGGPPLSST 84


                  ....*..
gi 148747499  657 VTLTIAV 663
Cdd:pfam00028  85 ATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 474-559 5.44e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.84  E-value: 5.44e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499   474 TAQDPDSGENAQVIYSLSEDTIQGapmssYVSINSNTGVLYALRSFDYEQFQDLKLLVTARDSGTPPLSSNVSLSLSVLD 553
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDG-----LFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 148747499   554 QNDNTP 559
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
354-441 1.59e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.64  E-value: 1.59e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499  354 SIQEASSPGTVIALFNVHDSDSGENGLVTCSI---PDNLPFRLEKTYGnyhRLLIHRTLDREEVSDYNITITATDQGTPP 430
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlggGPGGNFRIDPDTG---DISTTKPLDRESIGEYELTVEATDSGGPP 80

                          90
                  ....*....|.
gi 148747499  431 LSTETYISLQV 441
Cdd:pfam00028  81 LSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
137-231 7.72e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 59.24  E-value: 7.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499  137 REIKVAESENPGTRFPLPEAFDLDIGVNALQGYQLSS---NDHFSLDVQSGpdgikypELVLENALDREEEAVHHLVLTA 213
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGggpGGNFRIDPDTG-------DISTTKPLDRESIGEYELTVEA 73

                          90
                  ....*....|....*...
gi 148747499  214 FDGGDPVRSGTATIQVTL 231
Cdd:pfam00028  74 TDSGGPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 29-128 2.91e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 55.01  E-value: 2.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499  29 QIRYSVPEELERGSVVGNL-AADLGLepGKLAERGVRIVSRGKTQLFALNPRSGSLVTAGRVDREglcdrsPKCTANLEI 107
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVsATDPDS--GENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE------EQSSYTLTV 72

                         90       100
                 ....*....|....*....|....*.
gi 148747499 108 LLEDKVRILA-----IEVEIIDVNDN 128
Cdd:cd11304   73 TATDGGGPPLsstatVTITVLDVNDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 30-128 8.65e-07

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 48.11  E-value: 8.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747499  30 IRYSVPEELERGSVVGNLAADLglepGKLAERGVRIVSRGK---TQLFALNPRSGSLVTAGRVDREGLCDRSPKCTAnLE 106
Cdd:cd00031    2 PDGSAVEGRSRGSFRVSIPTDL----IASSGEIIKISAAGKealPSWLHWEPHSGILEGLEKLDREDKGVHYISVSA-AS 76

                         90       100
                 ....*....|....*....|..
gi 148747499 107 ILLEDKVRILAIEVEIIDVNDN 128
Cdd:cd00031   77 LGANVPQTSSVFSIEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 64-130 6.34e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 42.34  E-value: 6.34e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148747499    64 RIVSRGKTQLFALNPRSGSLVTAGRVDREglcdrsPKCTANLEILLEDK-VRILA----IEVEIIDVNDNAP 130
Cdd:smart00112  16 SILSGNDDGLFSIDPETGEITTTKPLDRE------EQPEYTLTVEATDGgGPPLSstatVTITVLDVNDNAP 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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