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Conserved domains on  [gi|15829939|ref|NP_308712|]
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hypothetical protein ECs_0685 [Escherichia coli O157:H7 str. Sakai]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11434433)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
55-181 5.61e-37

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 128.12  E-value: 5.61e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829939  55 ELSAIHGHSTSQYRLGEFYLHGsDGKPLDYTQARYWYEQSAEQENPRAQSKLGWIYLKGLGVKPDTRKAILWYKEAAEQG 134
Cdd:COG0790  91 EKAAEQGDAEAQYNLGLMYEEG-LGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQG 169

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 15829939 135 YAHAQYTLGLIYRNGSGINVNHYESQKWLKLAAKQHYKNAERLLAGL 181
Cdd:COG0790 170 DADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRL 216
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
55-181 5.61e-37

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 128.12  E-value: 5.61e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829939  55 ELSAIHGHSTSQYRLGEFYLHGsDGKPLDYTQARYWYEQSAEQENPRAQSKLGWIYLKGLGVKPDTRKAILWYKEAAEQG 134
Cdd:COG0790  91 EKAAEQGDAEAQYNLGLMYEEG-LGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQG 169

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 15829939 135 YAHAQYTLGLIYRNGSGINVNHYESQKWLKLAAKQHYKNAERLLAGL 181
Cdd:COG0790 170 DADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRL 216
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 100-135 7.20e-09

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 49.09  E-value: 7.20e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 15829939    100 PRAQSKLGWIYLKGLGVKPDTRKAILWYKEAAEQGY 135
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 100-134 1.87e-08

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 48.29  E-value: 1.87e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 15829939   100 PRAQSKLGWIYLKGLGVKPDTRKAILWYKEAAEQG 134
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
55-181 5.61e-37

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 128.12  E-value: 5.61e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829939  55 ELSAIHGHSTSQYRLGEFYLHGsDGKPLDYTQARYWYEQSAEQENPRAQSKLGWIYLKGLGVKPDTRKAILWYKEAAEQG 134
Cdd:COG0790  91 EKAAEQGDAEAQYNLGLMYEEG-LGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQG 169

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 15829939 135 YAHAQYTLGLIYRNGSGINVNHYESQKWLKLAAKQHYKNAERLLAGL 181
Cdd:COG0790 170 DADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRL 216
TPR COG0790
TPR repeat [General function prediction only];
31-169 2.15e-32

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 116.18  E-value: 2.15e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829939  31 KAMVNYAFDYLSSPGSLPFTTAATEL---SAIHGHSTSQYRLGEFYLHGsDGKPLDYTQARYWYEQSAEQENPRAQSKLG 107
Cdd:COG0790 100 EAQYNLGLMYEEGLGVPQDYAKALEWyekAAEQGDADAQYNLGLLYLNG-EGVPKDPAKAAEWYRKAAEQGDADAQYNLG 178

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15829939 108 WIYLKGLGVKPDTRKAILWYKEAAEQGYAHAQYTLGLIYRNGSGINVNHYESQKWLKLAAKQ 169
Cdd:COG0790 179 VLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
52-181 4.51e-22

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 89.22  E-value: 4.51e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829939  52 AATELSAIHGHSTSQYRLGEFYLHGSDGKPLDYTQARYWYEQSAEQENPRAQSKLGWIYLKGLGVKPDTRKAILWYKEAA 131
Cdd:COG0790  15 AAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEKAA 94

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 15829939 132 EQGYAHAQYTLGLIYRNGSGINVNHYESQKWLKLAAKQHYKNAERLLAGL 181
Cdd:COG0790  95 EQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLL 144
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 100-135 7.20e-09

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 49.09  E-value: 7.20e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 15829939    100 PRAQSKLGWIYLKGLGVKPDTRKAILWYKEAAEQGY 135
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 100-134 1.87e-08

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 48.29  E-value: 1.87e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 15829939   100 PRAQSKLGWIYLKGLGVKPDTRKAILWYKEAAEQG 134
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
TPR COG0790
TPR repeat [General function prediction only];
81-179 3.20e-07

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 48.77  E-value: 3.20e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15829939  81 PLDYTQARYWYEQSAEQENPRAQSKLGWIYLKGLGVKPDTRKAILWYKEAAEQGYAHAQYTLGLIYRNGSGINVNHYESQ 160
Cdd:COG0790   8 AAAAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKAL 87

                        90
                ....*....|....*....
gi 15829939 161 KWLKLAAKQHYKNAERLLA 179
Cdd:COG0790  88 EWFEKAAEQGDAEAQYNLG 106
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 63-97 2.87e-05

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 39.43  E-value: 2.87e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 15829939    63 STSQYRLGEFYLHGSDGKPlDYTQARYWYEQSAEQ 97
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPK-DPEKALEWYEKAAEL 34
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 65-99 8.72e-05

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 38.31  E-value: 8.72e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 15829939     65 SQYRLGEFYLHGsDGKPLDYTQARYWYEQSAEQEN 99
Cdd:smart00671   3 AQYNLGQMYEYG-LGVPKDLEKALEYYKKAAELGN 36
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 136-171 1.52e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 37.54  E-value: 1.52e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 15829939    136 AHAQYTLGLIYRNGSGINVNHYESQKWLKLAAKQHY 171
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 136-169 3.75e-03

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 33.65  E-value: 3.75e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 15829939   136 AHAQYTLGLIYRNGSGINVNHYESQKWLKLAAKQ 169
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAEL 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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