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Conserved domains on  [gi|15830052|ref|NP_308825|]
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membrane protein [Escherichia coli O157:H7 str. Sakai]

Protein Classification

anion permease( domain architecture ID 10469635)

anion permease translocates charged substrates such as sodium, arsenate, antimonite, sulfate and organic anions across biological membranes; similar to Eschericha coli L-tartrate/succinate antiporter

Gene Ontology:  GO:0022857|GO:0005886
TCDB:  2.A.47

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
3-474 0e+00

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


:

Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 540.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052     3 KKSLWKLILILAIPCIIGFMPAPAGLSELAWVLFGIYLAAIVGLVIKPFPEPVVLLIAVAASMVVVGNLSdgAFKTTAVL 82
Cdd:pfam00939   1 LTLWWKLLALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLL--AKALSWAL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052    83 SGYSSGTTWLVFSAFTLSAAFVTTGLGKRIAYLLIGKIGNTTLGLGYVTVFLDLVLAPATPSNTARAGGIVLPIINSVAV 162
Cdd:pfam00939  79 SGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKRTLGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052   163 ALGSEPEK-SPRRVGHYLMMSIYMVTKTTSYMFFTAMAGNILALKMINDILHLQISWGGWALAAGLPGIIMLLVTPLVIY 241
Cdd:pfam00939 159 AFGSDPEKgSERRIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNSILGVTITWASWFLAAIPPGVILLLLAPLLLY 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052   242 TMYPPEIKKV-DNKTIAKAGLAELGPMKIREKMLLGVFVLALLGWIFSKSLGVDESSVAIVVMATMLLLGIVTWEDVVKN 320
Cdd:pfam00939 239 VLYPPEIKSVpDAKAIAKTELKELGPMTFREKALLGLFVLLLLLWIFGGSLNIDATTVAIIGLALMLLLRILDWKDIVKN 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052   321 KGGWNTLIWYGGIIGLSSLLSKVKFFEWLAEVFKNNLAfDGHGNVAFFVIIFLSIIVRYFFASGSAYIVAMLPVFAMLAN 400
Cdd:pfam00939 319 KGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLS-GFSPAMAFIIILSLFYLSHYLFASATAHTAAMLPIFAAVAQ 397
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15830052   401 VS-GAPLMLTALALLFSNSYGGMVTHYGGAAGPVIFGVGYNDIKSWWLVGAVLTILTFLVHITLGVWWWNMLIGW 474
Cdd:pfam00939 398 AIpGAPPLLAALLLGFAISLGGFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWWWKPLGSL 472
 
Name Accession Description Interval E-value
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
3-474 0e+00

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 540.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052     3 KKSLWKLILILAIPCIIGFMPAPAGLSELAWVLFGIYLAAIVGLVIKPFPEPVVLLIAVAASMVVVGNLSdgAFKTTAVL 82
Cdd:pfam00939   1 LTLWWKLLALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLL--AKALSWAL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052    83 SGYSSGTTWLVFSAFTLSAAFVTTGLGKRIAYLLIGKIGNTTLGLGYVTVFLDLVLAPATPSNTARAGGIVLPIINSVAV 162
Cdd:pfam00939  79 SGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKRTLGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052   163 ALGSEPEK-SPRRVGHYLMMSIYMVTKTTSYMFFTAMAGNILALKMINDILHLQISWGGWALAAGLPGIIMLLVTPLVIY 241
Cdd:pfam00939 159 AFGSDPEKgSERRIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNSILGVTITWASWFLAAIPPGVILLLLAPLLLY 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052   242 TMYPPEIKKV-DNKTIAKAGLAELGPMKIREKMLLGVFVLALLGWIFSKSLGVDESSVAIVVMATMLLLGIVTWEDVVKN 320
Cdd:pfam00939 239 VLYPPEIKSVpDAKAIAKTELKELGPMTFREKALLGLFVLLLLLWIFGGSLNIDATTVAIIGLALMLLLRILDWKDIVKN 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052   321 KGGWNTLIWYGGIIGLSSLLSKVKFFEWLAEVFKNNLAfDGHGNVAFFVIIFLSIIVRYFFASGSAYIVAMLPVFAMLAN 400
Cdd:pfam00939 319 KGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLS-GFSPAMAFIIILSLFYLSHYLFASATAHTAAMLPIFAAVAQ 397
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15830052   401 VS-GAPLMLTALALLFSNSYGGMVTHYGGAAGPVIFGVGYNDIKSWWLVGAVLTILTFLVHITLGVWWWNMLIGW 474
Cdd:pfam00939 398 AIpGAPPLLAALLLGFAISLGGFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWWWKPLGSL 472
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
23-468 1.23e-163

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 469.52  E-value: 1.23e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052    23 PAPAGLSELAWVLFGIYLAAIVGLVIKPFPEPVVLLIAVAASMVVVGNLSdgAFKTTAVLSGYSSGTTWLVFSAFTLSAA 102
Cdd:TIGR00785   1 PVPDGLNSGAWLLLAIFVAAIVGWILEPLPLPVTALLAIPIIAVLLGVLS--AFKFKNALSGFADPTIWLFFGAFILATA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052   103 FVTTGLGKRIAYLLIGKIGNTTLGLGYVTVFLDLVLAPATPSNTARAGGIVLPIINSVAVALGSEPEKSPRRVGHYLMMS 182
Cdd:TIGR00785  79 LVKTGLGKRIAYKLVGKMGGTTLGLGYFLVFLETLLAPMWPSNTARAGGILLPIIKSLLPLLGSKPEKSPRKIGKYLMLG 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052   183 IYMVTKTTSYMFFTAMAGNILALKMINDILHLQISWGGWALAAGLPGIIMLLVTPLVIYTMYPPEIKKVDN-KTIAKAGL 261
Cdd:TIGR00785 159 IAYSASIGSSGFLTGSAPNALAAGILSKILGIQISWGDWFLAGLPLGIILLLLVPLLLYVLFPPELKLKDEvDLWAKEEL 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052   262 AELGPMKIREKMLLGVFVLALLGWIFSKSLGVDESSVAIVVMATMLLLGIVTWEDVVKNKGGWNTLIWYGGIIGLSSLLS 341
Cdd:TIGR00785 239 EEMGPMSFREKALLGIFLLALLLWIFGGSLGINASVVALLAVVLMLFLGIVTWKDIQKNKVAWNTLILFGGLIGLAGGLK 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052   342 KVKFFEWLAEVFKNNLAFDgHGNVAFFVIIFLSIIVRYFFASGSAYIVAMLPVFAMLANVSGAPLMLTALALLFSNSYGG 421
Cdd:TIGR00785 319 KSGFIKWFSEKLVGILDGL-SPTIAVLVLVVLFYIILYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMG 397
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 15830052   422 MVTHYGGAAGPVIFGVGYNDIKSWWLVGAVLTILTFLVHITLGVWWW 468
Cdd:TIGR00785 398 FLTPYATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVLLLVGTLWW 444
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
94-470 8.08e-78

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 247.37  E-value: 8.08e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052  94 FSAFTLSAAFVTTGLGKRIAYLLIGKIGNTTLGLGYVTVFLDLVLAPATpSNTARAGgIVLPIINSVAVALGSEpekSPR 173
Cdd:COG0471   1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFI-SNTARAA-MMLPIALSIAAALGSE---KRS 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052 174 RVGHYLMMSIYMVTKTTSYMFFTAMAGNILALKMINDILHLQISWGGWALAAGLPGIIMLLVTPLVIYTMYPPEIKKVDN 253
Cdd:COG0471  76 KFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIPISFFEWMLVGLPVALVGLLLLWLVLYRLLPPEIKEVPG 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052 254 -KTIAKAGLAELGPMKIREKMLLGVFVLALLGWIFSKSLGVDESSVAIVVMATMLLLGIVTWEDVVKnKGGWNTLIWYGG 332
Cdd:COG0471 156 sKEVIREELAELGPLSRREKIALAIFALTVLLWITGSLHGIPIAVVALLGAVLLLLTGVLTWKDAYK-SIPWGVLLLFGG 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052 333 IIGLSSLLSKVKFFEWLAEVFKNnlAFDGHGNVAFFVIIFLSIIVRYFFASGSAYIVAMLPVFAMLANVSGAPLMLTALA 412
Cdd:COG0471 235 GLALGAALEKTGLAAWLADALLP--LLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALA 312
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15830052 413 LLFSNSYGGMvTHYGGAAGPVIFGVGYNDIKSWWLVGAVLTILTFLVHITLGVWWWNM 470
Cdd:COG0471 313 VAFAASCAFL-LPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWPL 369
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
59-463 9.66e-16

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 78.83  E-value: 9.66e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052  59 IAVAASMVVVGNLSDGAFKTTAVLSGYSSGTTWLVFSAFTLSAAFVTTGLGKRIAYLLIGKIGNTtlGLGYVTVFLDLVL 138
Cdd:cd00625  11 RAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGS--RRLLLLLMLLTAA 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052 139 APATPSNTARAgGIVLPIINSVAVALGSEPEKsprrvghYLMMSIYMVTKTTSYMFFTAMAGNILALKMINdilhlqISW 218
Cdd:cd00625  89 LSAFFSNDATA-VLLTPIVLALLRKLGLSPPV-------PLLLALAFAANIGGAATPIGNPPNLIIASLSG------LGF 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052 219 GGWALAAGLPGIIMLLVTPLVIYTMYPPEIKKVDNKTIAKAGLAELGPMKIREKMLLGVFVLALLGWIFSKSLGVDESSV 298
Cdd:cd00625 155 LDFLAFMAPPALGLLLLLLGLLYLLFRKKLLLPDEDKLTVLAEPLPARPLLKKFLLLALLLLLLFVLLFFFLIPLGLIAL 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052 299 AIVVMATMLLLGIVTWEDVVKnKGGWNTLIWYGGIIGLSSLLSKVKFFEWLAEvfkNNLAFDGHGNVAFFVIIFLSIIVR 378
Cdd:cd00625 235 LGALLLLLLLVRGLDPEEVLK-SVDWGTLLFFAGLFVLVGALESTGLLEWLAE---LLVALVGLPPLAALLLIGLLSALL 310
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052 379 YFFASGSAYIVAMLPVFAMLANVSGAplmltALALLFSNSYGGMVTHYGGAAGPVIFGVGYNDIK--SWW---LVGAVLT 453
Cdd:cd00625 311 SNFISNVPTVALLLPIAASLAPPEPA-----WLALALGSTLGGNLTLIGSLANLIPLGAAENAGVgiSFGeflKVGLPLT 385
                       410
                ....*....|
gi 15830052 454 ILTFLVHITL 463
Cdd:cd00625 386 LLSLVVSLLY 395
 
Name Accession Description Interval E-value
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
3-474 0e+00

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 540.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052     3 KKSLWKLILILAIPCIIGFMPAPAGLSELAWVLFGIYLAAIVGLVIKPFPEPVVLLIAVAASMVVVGNLSdgAFKTTAVL 82
Cdd:pfam00939   1 LTLWWKLLALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLL--AKALSWAL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052    83 SGYSSGTTWLVFSAFTLSAAFVTTGLGKRIAYLLIGKIGNTTLGLGYVTVFLDLVLAPATPSNTARAGGIVLPIINSVAV 162
Cdd:pfam00939  79 SGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKRTLGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052   163 ALGSEPEK-SPRRVGHYLMMSIYMVTKTTSYMFFTAMAGNILALKMINDILHLQISWGGWALAAGLPGIIMLLVTPLVIY 241
Cdd:pfam00939 159 AFGSDPEKgSERRIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNSILGVTITWASWFLAAIPPGVILLLLAPLLLY 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052   242 TMYPPEIKKV-DNKTIAKAGLAELGPMKIREKMLLGVFVLALLGWIFSKSLGVDESSVAIVVMATMLLLGIVTWEDVVKN 320
Cdd:pfam00939 239 VLYPPEIKSVpDAKAIAKTELKELGPMTFREKALLGLFVLLLLLWIFGGSLNIDATTVAIIGLALMLLLRILDWKDIVKN 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052   321 KGGWNTLIWYGGIIGLSSLLSKVKFFEWLAEVFKNNLAfDGHGNVAFFVIIFLSIIVRYFFASGSAYIVAMLPVFAMLAN 400
Cdd:pfam00939 319 KGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLS-GFSPAMAFIIILSLFYLSHYLFASATAHTAAMLPIFAAVAQ 397
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15830052   401 VS-GAPLMLTALALLFSNSYGGMVTHYGGAAGPVIFGVGYNDIKSWWLVGAVLTILTFLVHITLGVWWWNMLIGW 474
Cdd:pfam00939 398 AIpGAPPLLAALLLGFAISLGGFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWWWKPLGSL 472
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
23-468 1.23e-163

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 469.52  E-value: 1.23e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052    23 PAPAGLSELAWVLFGIYLAAIVGLVIKPFPEPVVLLIAVAASMVVVGNLSdgAFKTTAVLSGYSSGTTWLVFSAFTLSAA 102
Cdd:TIGR00785   1 PVPDGLNSGAWLLLAIFVAAIVGWILEPLPLPVTALLAIPIIAVLLGVLS--AFKFKNALSGFADPTIWLFFGAFILATA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052   103 FVTTGLGKRIAYLLIGKIGNTTLGLGYVTVFLDLVLAPATPSNTARAGGIVLPIINSVAVALGSEPEKSPRRVGHYLMMS 182
Cdd:TIGR00785  79 LVKTGLGKRIAYKLVGKMGGTTLGLGYFLVFLETLLAPMWPSNTARAGGILLPIIKSLLPLLGSKPEKSPRKIGKYLMLG 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052   183 IYMVTKTTSYMFFTAMAGNILALKMINDILHLQISWGGWALAAGLPGIIMLLVTPLVIYTMYPPEIKKVDN-KTIAKAGL 261
Cdd:TIGR00785 159 IAYSASIGSSGFLTGSAPNALAAGILSKILGIQISWGDWFLAGLPLGIILLLLVPLLLYVLFPPELKLKDEvDLWAKEEL 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052   262 AELGPMKIREKMLLGVFVLALLGWIFSKSLGVDESSVAIVVMATMLLLGIVTWEDVVKNKGGWNTLIWYGGIIGLSSLLS 341
Cdd:TIGR00785 239 EEMGPMSFREKALLGIFLLALLLWIFGGSLGINASVVALLAVVLMLFLGIVTWKDIQKNKVAWNTLILFGGLIGLAGGLK 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052   342 KVKFFEWLAEVFKNNLAFDgHGNVAFFVIIFLSIIVRYFFASGSAYIVAMLPVFAMLANVSGAPLMLTALALLFSNSYGG 421
Cdd:TIGR00785 319 KSGFIKWFSEKLVGILDGL-SPTIAVLVLVVLFYIILYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMG 397
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 15830052   422 MVTHYGGAAGPVIFGVGYNDIKSWWLVGAVLTILTFLVHITLGVWWW 468
Cdd:TIGR00785 398 FLTPYATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVLLLVGTLWW 444
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
94-470 8.08e-78

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 247.37  E-value: 8.08e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052  94 FSAFTLSAAFVTTGLGKRIAYLLIGKIGNTTLGLGYVTVFLDLVLAPATpSNTARAGgIVLPIINSVAVALGSEpekSPR 173
Cdd:COG0471   1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFI-SNTARAA-MMLPIALSIAAALGSE---KRS 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052 174 RVGHYLMMSIYMVTKTTSYMFFTAMAGNILALKMINDILHLQISWGGWALAAGLPGIIMLLVTPLVIYTMYPPEIKKVDN 253
Cdd:COG0471  76 KFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIPISFFEWMLVGLPVALVGLLLLWLVLYRLLPPEIKEVPG 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052 254 -KTIAKAGLAELGPMKIREKMLLGVFVLALLGWIFSKSLGVDESSVAIVVMATMLLLGIVTWEDVVKnKGGWNTLIWYGG 332
Cdd:COG0471 156 sKEVIREELAELGPLSRREKIALAIFALTVLLWITGSLHGIPIAVVALLGAVLLLLTGVLTWKDAYK-SIPWGVLLLFGG 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052 333 IIGLSSLLSKVKFFEWLAEVFKNnlAFDGHGNVAFFVIIFLSIIVRYFFASGSAYIVAMLPVFAMLANVSGAPLMLTALA 412
Cdd:COG0471 235 GLALGAALEKTGLAAWLADALLP--LLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALA 312
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15830052 413 LLFSNSYGGMvTHYGGAAGPVIFGVGYNDIKSWWLVGAVLTILTFLVHITLGVWWWNM 470
Cdd:COG0471 313 VAFAASCAFL-LPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWPL 369
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
59-463 9.66e-16

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 78.83  E-value: 9.66e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052  59 IAVAASMVVVGNLSDGAFKTTAVLSGYSSGTTWLVFSAFTLSAAFVTTGLGKRIAYLLIGKIGNTtlGLGYVTVFLDLVL 138
Cdd:cd00625  11 RAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGS--RRLLLLLMLLTAA 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052 139 APATPSNTARAgGIVLPIINSVAVALGSEPEKsprrvghYLMMSIYMVTKTTSYMFFTAMAGNILALKMINdilhlqISW 218
Cdd:cd00625  89 LSAFFSNDATA-VLLTPIVLALLRKLGLSPPV-------PLLLALAFAANIGGAATPIGNPPNLIIASLSG------LGF 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052 219 GGWALAAGLPGIIMLLVTPLVIYTMYPPEIKKVDNKTIAKAGLAELGPMKIREKMLLGVFVLALLGWIFSKSLGVDESSV 298
Cdd:cd00625 155 LDFLAFMAPPALGLLLLLLGLLYLLFRKKLLLPDEDKLTVLAEPLPARPLLKKFLLLALLLLLLFVLLFFFLIPLGLIAL 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052 299 AIVVMATMLLLGIVTWEDVVKnKGGWNTLIWYGGIIGLSSLLSKVKFFEWLAEvfkNNLAFDGHGNVAFFVIIFLSIIVR 378
Cdd:cd00625 235 LGALLLLLLLVRGLDPEEVLK-SVDWGTLLFFAGLFVLVGALESTGLLEWLAE---LLVALVGLPPLAALLLIGLLSALL 310
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052 379 YFFASGSAYIVAMLPVFAMLANVSGAplmltALALLFSNSYGGMVTHYGGAAGPVIFGVGYNDIK--SWW---LVGAVLT 453
Cdd:cd00625 311 SNFISNVPTVALLLPIAASLAPPEPA-----WLALALGSTLGGNLTLIGSLANLIPLGAAENAGVgiSFGeflKVGLPLT 385
                       410
                ....*....|
gi 15830052 454 ILTFLVHITL 463
Cdd:cd00625 386 LLSLVVSLLY 395
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
59-468 9.03e-11

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 63.37  E-value: 9.03e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052  59 IAVAASMVVVGNLSDGAFKTTAVLSGYSSGTTWLVFSAFTLSAAFVTTGLGKRIAYLLIGKIGNTTLGLgYVTVFLDLVL 138
Cdd:cd01115  18 LDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRL-LLLLMLVTAF 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052 139 APATPSNTArAGGIVLPIINSVAVALGSEPEKsprrvghyLMMSIYMVTKTTSYMFFTAMAGNILALKMINDILHLQISW 218
Cdd:cd01115  97 LSAFMSNTA-TVAIMLPVALGLAAKLDISPSR--------LLMPLAFAASIGGMLTLIGTPPNLVASGYLESLGGQGFSF 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052 219 GGWALAaglpGIIMLLVTPLVIYTMYPpeikkvdnktiakaglaelgpmkirekmlLGVFVLALLGWIFSKS-LGVDESS 297
Cdd:cd01115 168 FEFTPI----GLPLLIIGLLYLWFIFR-----------------------------LAVLIITIVLLAALAAiTGLLPVS 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052 298 VAIVVMATMLLLGIVTWEDVVKNKGGWNTLIWYGGIIGLSSLLSKVKFFEWLAEVFKNnlAFDGHGNVAFFVIIFLSIIV 377
Cdd:cd01115 215 VAIAIGAIVLVFGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALIS--LLGGLPPFAILLLLCLLTLV 292
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052 378 RYFFASGSAYIVAMLPVFAMLANVSGAPLMLTALALLFSNSyGGMVTHYGGAAGPVIFGVGYNDIKSWWLVGAVLTILTF 457
Cdd:cd01115 293 LTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGAS-CAFMLPVGTPPNAIVLGPGGYKFSDFAKVGLPLSILSL 371
                       410
                ....*....|.
gi 15830052 458 LVHITLGVWWW 468
Cdd:cd01115 372 VVSVTMIPLIW 382
CitMHS pfam03600
Citrate transporter;
56-415 1.63e-08

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 56.17  E-value: 1.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052    56 VLLIAVAASMVVVGNLSDGAFKTTAVLSGYSSGTTWLVFSAFTLSAAFVTTGLGKRIAYLLIGKIGNTTLGLGYVTVFLD 135
Cdd:pfam03600   8 KLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLAT 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052   136 LVLApATPSNTArAGGIVLPIINSVAVALGSEPEKsprrvghyLMMSIYMVTKTTSYMfftAMAGNILALkMINDILHLQ 215
Cdd:pfam03600  88 ALLS-AFLSNDG-TVLIMIPIVLALARRLGLPPSP--------LLIALAFAANIGGTA---TPIGDPPNI-IIASALGLS 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052   216 ISWGGWALAAGLpGIIMLLVTPLVIYTMYPPEIKKVDNKtiaKAGLAELGPMKIREKMLLGVFVLALLGWIFSKSLGvde 295
Cdd:pfam03600 154 FGDFGFFMFPPV-GVALLLVGLLPLLLIFRKLLPVRKEE---EAELEELRKRAIKDKLLLAISALVLALVILGFLLL--- 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052   296 SSVAIVVMATMLLLGIVTWEDVVKnKGGWNTLIWYGGIIGLSSLLSKVKFFEWLAEVFKNNLAFDGHGNVAFFVIIFLSI 375
Cdd:pfam03600 227 SVLALAGALLLLLTGVLDPEEALK-AVDWSTLLFFAGLFILVGALEKTGLADALADALGGLSGLLVALALILWLSALLSA 305
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 15830052   376 IVryffaSGSAYIVAMLP-VFAMLANVSGAPLMLTALALLF 415
Cdd:pfam03600 306 FI-----SNVPTAALMAPiIVGMAPAAGLGDPDPLAWALAV 341
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
32-459 1.16e-05

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 47.43  E-value: 1.16e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052  32 AWVLFGIYLAAIVGLVIKPF--PEPVVLLIAvAASMVVVGNLSDGAfkttaVLSGYSSGTTWLVFSAFTLSAAFVTTGLG 109
Cdd:COG1055   2 MILALAIFVLTYLLIILEPRglNRAVAALLG-AALLLLLGVVSLED-----ALEAIDWNTILFLLGMMIIVAILDESGFF 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052 110 KRIAYLLIGKIGNTTLGLGYVTVFLDLVLAPATPSNTARAggIVLPIINSVAVALGSEPEKsprrvghYLMMSIYMVTkT 189
Cdd:COG1055  76 EWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTAL--LLTPVVLAIARRLGLNPVP-------FLIAIVFAAN-I 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052 190 TSYMFFTamaGNILALkMINDILHlqISWGGWALAAGLPGIIMLLVTPLVIYTMYPPEIKKVDNKTiakagLAELGPMKI 269
Cdd:COG1055 146 GGAATPI---GNPTNI-MIASAGG--LSFLDFLANLFPPSLVSLLVTLLVLYLLFRKELPAAPDLE-----DDPKEAIKD 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052 270 REKMLLGVFVLALL--GWIFSKSLGVDESSVAIVVMATMLLLGIVTWEDVVKnKGGWNTLIWYGGIIGLSSLLSKVKFFE 347
Cdd:COG1055 215 RRLLRISLLVLALLlvGFVLHSFLGLPPALIALLGAAVLLLLARVDVREVLK-KVDWSTLLFFIGLFVVVGGLENTGLLD 293
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052 348 WLAEVFKNnlAFDGHGNVAFFVIIFLSIIVRYFFaSGSAYIVAMLPVFAMLANVSGAPLMLTALALlfSNSYGGMVTHYG 427
Cdd:COG1055 294 LLAELLAS--LTGGNLLLAALLILWLSAILSAVV-DNVPLVAALLPLIPDLGATGNPEPLWLALAL--GATLGGNLTPIG 368
                       410       420       430
                ....*....|....*....|....*....|....*..
gi 15830052 428 GAAGPVIFGV--GYNDIKSWW---LVGAVLTILTFLV 459
Cdd:COG1055 369 SAANVIVLGIaeKKGIKISFGeflKVGLPLTLLTLLI 405
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
223-437 3.08e-05

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 46.09  E-value: 3.08e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052 223 LAAGLPGIIMLLVTPLVIYTMYPPEIKKVDNKTIAKagLAELGPMK-IREKMLL----GVFVLALLGWIFSKSLGVDESS 297
Cdd:cd01116 166 LLHMLPSVVLALVVTFILLYFLYRNILKAREEDVLA--LAELEPKYpIKDKVLLlkslTILTLVIIGFVLHSPLGVSLGW 243
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052 298 VAIV-VMATMLLLGIVTWEDVVKnKGGWNTLIWYGGIIGLSSLLSKVKFFEWLAEVFKnnLAFDGHGNVAFFVIIFLSII 376
Cdd:cd01116 244 IALLgALLLLLLADKLDFEDVLS-RVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLV--GVILGRIAVAVILILWISAL 320
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15830052 377 VRYFFaSGSAYIVAMLPVFAMLANVSGAPLMLTALALLFSNSYGGMVTHYGGAAGPVIFGV 437
Cdd:cd01116 321 LSAFI-DNIPVTATMIPIVKDLASQLGIPLLPLWWALALGACLGGNGTLIGASANVVAAGI 380
ArsB_permease cd01118
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ...
273-400 2.22e-03

Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.


Pssm-ID: 238538 [Multi-domain]  Cd Length: 416  Bit Score: 40.33  E-value: 2.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830052 273 MLLGVFVLALLGwIFSKSLGVDESSVAIVVMATMLLLGIVTWEDVVKNKG-GWNTLIWYGGIIGLSSLLSKVKFFEWLAE 351
Cdd:cd01118   1 LAIAIFVLTLVL-VIWRPFGLPEAVWAVLGAVIALILGLVSPHDALEVWGiVWDVTLTLIGVILLSLLLDEEGFFEWVAA 79
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 15830052 352 VFKNnlAFDGHGNVAFFVIIFLSIIVRYFFASGSAYIVAMLPVFAMLAN 400
Cdd:cd01118  80 LAAR--WARGSGRKLFTLIVLLGAAVTAFFANDGTALILTPIVIALLRA 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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