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Conserved domains on  [gi|15831462|ref|NP_310235|]
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phage antirepressor protein [Escherichia coli O157:H7 str. Sakai]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 366238)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family; HTH domain binds DNA and may function as a transcriptional regulator

Gene Ontology:  GO:0003677|GO:0006355

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_XRE super family cl22854
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 2-52 1.90e-14

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


The actual alignment was detected with superfamily member pfam14549:

Pssm-ID: 473980  Cd Length: 60  Bit Score: 61.24  E-value: 1.90e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 15831462    2 KKSEVLGYFGGVVKTAAALGTSKTTVSMWGEDVPWKWALLIQAVTAGALKY 52
Cdd:pfam14549  1 KKKDVIAHFGGVSKVAKALGVTPGAVSQWGEDVPELRAYQIERLTAGALKV 51
 
Name Accession Description Interval E-value
P22_Cro pfam14549
DNA-binding transcriptional regulator Cro; Bacteriophage P22 Cro protein represses genes ...
 2-52 1.90e-14

DNA-binding transcriptional regulator Cro; Bacteriophage P22 Cro protein represses genes normally expressed in early phage development and is necessary for the late stage of lytic growth. It does this by binding to the OL and OR operator-regions normally used by the repressor protein for lysogenic maintenance.


Pssm-ID: 405268  Cd Length: 60  Bit Score: 61.24  E-value: 1.90e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 15831462    2 KKSEVLGYFGGVVKTAAALGTSKTTVSMWGEDVPWKWALLIQAVTAGALKY 52
Cdd:pfam14549  1 KKKDVIAHFGGVSKVAKALGVTPGAVSQWGEDVPELRAYQIERLTAGALKV 51
PRK09744 PRK09744
DNA-binding transcriptional regulator DicC; Provisional
 1-53 7.17e-08

DNA-binding transcriptional regulator DicC; Provisional


Pssm-ID: 137503  Cd Length: 75  Bit Score: 44.95  E-value: 7.17e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 15831462   1 MKKSEVLGYFGGVVKTAAALGTSKTTVSMWGEDVPWKWALLIQAVTAGALKYE 53
Cdd:PRK09744  1 MLKIDAIAFFGSKTKLANAAGVRLASVAAWGELVPEGRAMRLQEASGGELQYD 53
YdaS COG4197
DNA-binding transcriptional regulator YdaS, prophage-encoded, Cro superfamily [Transcription];
5-54 1.47e-04

DNA-binding transcriptional regulator YdaS, prophage-encoded, Cro superfamily [Transcription];


Pssm-ID: 443351  Cd Length: 68  Bit Score: 36.04  E-value: 1.47e-04
                       10        20        30        40        50
               ....*....|....*....|....*....|....*....|....*....|....
gi 15831462  5 EVLGYFGGVVKTAAALGTSKTTVSMWGED---VPWKWALLIQAVTAGALK-YEL 54
Cdd:COG4197  3 KAIEALGSQSALARALGVSQQAVSQWLNGkrrVPAERCLAIERATGGAVTrEEL 56
 
Name Accession Description Interval E-value
P22_Cro pfam14549
DNA-binding transcriptional regulator Cro; Bacteriophage P22 Cro protein represses genes ...
 2-52 1.90e-14

DNA-binding transcriptional regulator Cro; Bacteriophage P22 Cro protein represses genes normally expressed in early phage development and is necessary for the late stage of lytic growth. It does this by binding to the OL and OR operator-regions normally used by the repressor protein for lysogenic maintenance.


Pssm-ID: 405268  Cd Length: 60  Bit Score: 61.24  E-value: 1.90e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 15831462    2 KKSEVLGYFGGVVKTAAALGTSKTTVSMWGEDVPWKWALLIQAVTAGALKY 52
Cdd:pfam14549  1 KKKDVIAHFGGVSKVAKALGVTPGAVSQWGEDVPELRAYQIERLTAGALKV 51
PRK09744 PRK09744
DNA-binding transcriptional regulator DicC; Provisional
 1-53 7.17e-08

DNA-binding transcriptional regulator DicC; Provisional


Pssm-ID: 137503  Cd Length: 75  Bit Score: 44.95  E-value: 7.17e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 15831462   1 MKKSEVLGYFGGVVKTAAALGTSKTTVSMWGEDVPWKWALLIQAVTAGALKYE 53
Cdd:PRK09744  1 MLKIDAIAFFGSKTKLANAAGVRLASVAAWGELVPEGRAMRLQEASGGELQYD 53
YdaS COG4197
DNA-binding transcriptional regulator YdaS, prophage-encoded, Cro superfamily [Transcription];
5-54 1.47e-04

DNA-binding transcriptional regulator YdaS, prophage-encoded, Cro superfamily [Transcription];


Pssm-ID: 443351  Cd Length: 68  Bit Score: 36.04  E-value: 1.47e-04
                       10        20        30        40        50
               ....*....|....*....|....*....|....*....|....*....|....
gi 15831462  5 EVLGYFGGVVKTAAALGTSKTTVSMWGED---VPWKWALLIQAVTAGALK-YEL 54
Cdd:COG4197  3 KAIEALGSQSALARALGVSQQAVSQWLNGkrrVPAERCLAIERATGGAVTrEEL 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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