|
Name |
Accession |
Description |
Interval |
E-value |
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
3-449 |
4.91e-82 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 260.40 E-value: 4.91e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 3 RLSITVRLTLLFILLLSVAGAGIVWTLYNGLASELKWRDDTTLINRTAQIKQLLIDGVNPDT----LPVYFNRMMDVSQD 78
Cdd:TIGR01386 1 PRSLTLRLALLFAAVTALVFALSGFMLYSSLERHFEERDREELQGKLEQVRRFLRDPADLDEdikrLQEKIDDLLVGHSD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 79 ILIIhgdgINKIVNRTNVSDDMLNNIPASETISAAG-IYRSIINDTEIDALRINIDEVSP------SLTVTVAKLASARH 151
Cdd:TIGR01386 81 LALS----ILNPDGRLLFERAQGAALVPAVAANDALlELDQADAKMTHYRSILRSVAALPggkgrkPVQITVALDINAHT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 152 NMLEQYKINSIIICIVAIILCSVLSPLLIRTGLREIKKLSGVTEALNYNDSREPVEVSALPRELKPLGQALNKMHHALVK 231
Cdd:TIGR01386 157 HLLDALRKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDQRLDPSRAPAELRELAQSFNAMLGRLED 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 232 DFERLSQFADDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLS 311
Cdd:TIGR01386 237 AFQRLSQFSADLAHELRTPLTNLLGQTQVALSQPRTGEEYREVLESNLEELERLSRMVSDMLFLARADNGQLALERVRLD 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 312 LNKEVENLLDYLEYLSDEKEICFKVECNQQIFADKILLQRMLSNLIVNAIRYSPEKSRIHItSFLDTNSYLNIDIASPGA 391
Cdd:TIGR01386 317 LAAELAKVAEYFEPLAEERGVRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITV-RIERRSDEVRVSVSNPGP 395
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15831960 392 KINEP--EKLFRRFWRGDNSRH--SVGQGLGLSLVKAIAELHGGSATYHYLNKHNVFRITLP 449
Cdd:TIGR01386 396 GIPPEhlSRLFDRFYRVDPARSnsGEGTGLGLAIVRSIMEAHGGRASAESPDGKTRFILRFP 457
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
175-449 |
4.57e-47 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 165.08 E-value: 4.57e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 175 LSPLLIRTGLREIKKLSGVTEALNYNDSREPVEVSALPRELKPLGQALNKMHHALVKDFERLSQFADDLAHELRTPINAL 254
Cdd:COG0642 49 LLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAI 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 255 LGQNQVTLSQTRsiAEYQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLSLNKEVENLLDYLEYLSDEKEICF 334
Cdd:COG0642 129 RGYLELLLEELD--EEQREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIEL 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 335 KVECNQQ---IFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDtNSYLNIDIASPGAKINEP--EKLFRRFWRGDNS 409
Cdd:COG0642 207 ELDLPDDlptVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRRE-GDRVRISVEDTGPGIPPEdlERIFEPFFRTDPS 285
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 15831960 410 RHSVGQGLGLSLVKAIAELHGGSATYHY-LNKHNVFRITLP 449
Cdd:COG0642 286 RRGGGTGLGLAIVKRIVELHGGTIEVESePGKGTTFTVTLP 326
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
221-452 |
6.40e-47 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 162.00 E-value: 6.40e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 221 ALNKMHHALVKDFERLSQFADDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIAGNI-EELENISRLTENILFLARAD 299
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIrESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 300 KNNVLVKLDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQQ---IFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFL 376
Cdd:COG2205 81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPElplVYADPELLEQVLANLLDNAIKYSPPGGTITISARR 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15831960 377 DTNsYLNIDIASPGAKINEP--EKLFRRFWRGDNSRHSVGQGLGLSLVKAIAELHGGSATYHY-LNKHNVFRITLPQRN 452
Cdd:COG2205 161 EGD-GVRISVSDNGPGIPEEelERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESePGGGTTFTVTLPLAE 238
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-449 |
2.84e-46 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 155.24 E-value: 2.84e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 349 LQRMLSNLIVNAIRYSPEKSRIHITSFLdTNSYLNIDIASPGAKINE--PEKLFRRFWRGDNSRHSVGQGLGLSLVKAIA 426
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFL-TDDVVNIMFKNPSSHPLDfkLEKLFERFYRGDNSRNTEGAGLGLSIAKAII 79
|
90 100
....*....|....*....|...
gi 15831960 427 ELHGGSATYHYLNKHNVFRITLP 449
Cdd:cd16923 80 ELHGGSASAEYDDNHDLFKVRLP 102
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
178-451 |
5.98e-43 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 157.63 E-value: 5.98e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 178 LLIRTGLREIKKLSGVTEALNYNDSREPVEVSALPRELKPLGQALNKMHHALVKDFERLSQFADDLAHELRTPINALLGQ 257
Cdd:PRK09835 204 LAVHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQ 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 258 NQVTLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLSLNKEVENLLDYLEYLSDEKEICFKVE 337
Cdd:PRK09835 284 TEIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELRFV 363
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 338 CNQ-QIFADKILLQRMLSNLIVNAIRYSPEKSRIhITSFLDTNSYLNIDIASPGAKINEPE--KLFRRFWRGDNSRHSVG 414
Cdd:PRK09835 364 GDPcQVAGDPLMLRRAISNLLSNALRYTPAGEAI-TVRCQEVDHQVQLVVENPGTPIAPEHlpRLFDRFYRVDPSRQRKG 442
|
250 260 270
....*....|....*....|....*....|....*....
gi 15831960 415 Q--GLGLSLVKAIAELHGGSATYHYLNKHNVFRITLPQR 451
Cdd:PRK09835 443 EgsGIGLAIVKSIVVAHKGTVAVTSDARGTRFVISLPRL 481
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
100-449 |
8.79e-42 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 152.40 E-value: 8.79e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 100 MLNNIPASETISAAGIYRSIINDTEIDALRINIDEVSPSLTVTVAKLASARHNMLEQYKINSIIICIVAIILCSVLSPLL 179
Cdd:COG5002 22 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLAL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 180 IRTGLREIKKLSGVTEALNYNDSREPVEVSALPRELKPLGQALNKMHHALVKDFERL-------SQFADDLAHELRTPIN 252
Cdd:COG5002 102 LILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELerleqmrREFVANVSHELRTPLT 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 253 ALLGQNQVTLSQ-TRSIAEYQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLSLNKEVENLLDYLEYLSDEKE 331
Cdd:COG5002 182 SIRGYLELLLDGaADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 332 ICFKVECNQQ---IFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDtNSYLNIDIASPGAKINEP--EKLFRRFWRG 406
Cdd:COG5002 262 IELELDLPEDpllVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREE-DDQVRISVRDTGIGIPEEdlPRIFERFYRV 340
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 15831960 407 DNS--RHSVGQGLGLSLVKAIAELHGGSATYHY-LNKHNVFRITLP 449
Cdd:COG5002 341 DKSrsRETGGTGLGLAIVKHIVEAHGGRIWVESePGKGTTFTITLP 386
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
185-451 |
1.16e-24 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 106.08 E-value: 1.16e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 185 REIKKLSGVTEALNYNdsrEPVEVSAL-PRELKPLGQALNKMHHALV-KDF-ERLSQfadDLAHELRTPINALLGQNQvt 261
Cdd:PRK11100 208 RSIRRLTRYADAVTEG---KPVPLPKLgSSELRELAQALESMRVKLEgKAYvEQYVQ---TLTHELKSPLAAIRGAAE-- 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 262 LSQTRSIAEYQKTIAGNIE-ELENISRLTENILFLARADKNNVLVKLDSLSLNKEVENLLDYLEYLSDEKEICFKVEC-N 339
Cdd:PRK11100 280 LLQEDPPPEDRARFTGNILtQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEAREAQAAAKGITLRLRPdD 359
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 340 QQIFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDtNSYLNIDIASPGAKINEP--EKLFRRFW---RGDNSRHSvg 414
Cdd:PRK11100 360 ARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVD-GEQVALSVEDQGPGIPDYalPRIFERFYslpRPANGRKS-- 436
|
250 260 270
....*....|....*....|....*....|....*...
gi 15831960 415 QGLGLSLVKAIAELHGGSATYHYLNKHNVF-RITLPQR 451
Cdd:PRK11100 437 TGLGLAFVREVARLHGGEVTLRNRPEGGVLaTLTLPRH 474
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
171-431 |
1.49e-23 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 102.60 E-value: 1.49e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 171 LCSVLSPLLIRTGLRE-IKKLSGVTEALNYNDSREPVEVSAlPRELKPLGQALNKMHHALVKDFERLSQFADDLAHELRT 249
Cdd:NF012163 175 LLAALAAFLLARGLLApVKRLVEATHRLAAGDYTTRVTPTS-NDELGKLAQDFNQLASTLEKNEQMRRDFMADISHELRT 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 250 PINALLGQNQVTLSQTRSIAeyQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLS----LNKEVENLLDYLEy 325
Cdd:NF012163 254 PLAVLRAELEAIQDGIRKFT--PESLDSLQAEVGTLTKLVDDLHDLSMSDEGALAYQKASVDlvplLEVEGGAFRERFA- 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 326 lSDEKEICFKVECNQQIFADKILLQRMLSNLIVNAIRYSPEKSRIHI-TSFLDTNSYLNIDIASPGAKINEPEKLFRRFW 404
Cdd:NF012163 331 -SAGLELEVSLPDSSLVFGDRDRLMQLFNNLLENSLRYTDSGGSLHIsASQRPKEVTLTVADSAPGVSDEQLARLFERFY 409
|
250 260
....*....|....*....|....*....
gi 15831960 405 RGDNSRH--SVGQGLGLSLVKAIAELHGG 431
Cdd:NF012163 410 RVEVSRNraSGGSGLGLAISLNIVQAHGG 438
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
349-448 |
3.09e-23 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 93.82 E-value: 3.09e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 349 LQRMLSNLIVNAIRYSPEKSRIHITSFLDtNSYLNIDIASPGAKINE--PEKLFRRFWRGDNSRHSVGQGLGLSLVKAIA 426
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQE-GDGVVLEVEDNGPGIPEedLERIFERFYRGDKSREGGGTGLGLAIVRRIV 79
|
90 100
....*....|....*....|...
gi 15831960 427 ELHGGSATYHY-LNKHNVFRITL 448
Cdd:cd00075 80 EAHGGRITVESePGGGTTFTVTL 102
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
178-435 |
6.47e-23 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 100.49 E-value: 6.47e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 178 LLIRTGL--REIKKLSGVTEALNYN--DSREPVEVSALPRELKPLGQALN----KMHHALVKdfERlsQFADDLAHELRT 249
Cdd:PRK10337 175 LIILMVLlgRELAPLKKLALALRMRdpDSETPLNATGVPSEVRPLVEALNqlfaRTHAMMVR--ER--RFTSDAAHELRS 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 250 PINALLGQNQVT-LSQTRSIAEyQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLSLNKEVENLLDYLEYLSD 328
Cdd:PRK10337 251 PLAALKVQTEVAqLSDDDPQAR-KKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSAVMDIYHTAQ 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 329 EKEICFKVECNqqifADKI-------LLQRMLSNLIVNAIRYSPEKSRIHITSfldTNSYLNIDIASPGAkinEPEKLFR 401
Cdd:PRK10337 330 QAGIDVRLTLN----AHPVirtgqplLLSLLVRNLLDNAIRYSPQGSVVDVTL---NARNFTVRDNGPGV---TPEALAR 399
|
250 260 270
....*....|....*....|....*....|....*..
gi 15831960 402 ---RFWRgDNSRHSVGQGLGLSLVKAIAELHGGSATY 435
Cdd:PRK10337 400 igeRFYR-PPGQEATGSGLGLSIVRRIAKLHGMNVSF 435
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
344-451 |
6.68e-23 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 93.10 E-value: 6.68e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 344 ADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDTNsYLNIDIASPGAKINE--PEKLFRRFWRGDNSRHSVGQ-GLGLS 420
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGD-HVEITVEDNGPGIPPedLEKIFEPFFRTDKRSRKIGGtGLGLS 79
|
90 100 110
....*....|....*....|....*....|..
gi 15831960 421 LVKAIAELHGGSATYHY-LNKHNVFRITLPQR 451
Cdd:smart00387 80 IVKKLVELHGGEISVESePGGGTTFTITLPLE 111
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
339-432 |
2.94e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 88.62 E-value: 2.94e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 339 NQQIFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDTNSYLNIDIASPGAKINEPEKLFRRFWRGDnSRHSVGQGLG 418
Cdd:cd16940 4 DIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAVIRVEDNGPGIDEEELEALFERFYRSD-GQNYGGSGLG 82
|
90
....*....|....
gi 15831960 419 LSLVKAIAELHGGS 432
Cdd:cd16940 83 LSIVKRIVELHGGQ 96
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
214-452 |
5.15e-21 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 95.24 E-value: 5.15e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 214 ELKPLGQALNKMHHALVKDFERLSQFADDLAHELRTPINALLGQNQVTLSQTRS-----IAEYQKTIAGNIEELeniSRL 288
Cdd:COG4251 260 ELEELEEELEERTAELERSNEELEQFAYVASHDLREPLRKISGFSQLLEEDYGDkldeeGREYLERIRDAAERM---QAL 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 289 TENILFLARADKNNVlvKLDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQQIFADKILLQRMLSNLIVNAIRYSPEKS 368
Cdd:COG4251 337 IDDLLAYSRVGRQEL--EFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPLPTVRGDPTLLRQVFQNLISNAIKYSRPGE 414
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 369 --RIHITSFLDTNSYLnIDIASPGAKINEP--EKLFRRFWRGDNSRHSVGQGLGLSLVKAIAELHGGSATYHY-LNKHNV 443
Cdd:COG4251 415 ppRIEIGAEREGGEWV-FSVRDNGIGIDPEyaEKIFEIFQRLHSRDEYEGTGIGLAIVKKIVERHGGRIWVESePGEGAT 493
|
....*....
gi 15831960 444 FRITLPQRN 452
Cdd:COG4251 494 FYFTLPKAP 502
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
209-432 |
7.04e-20 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 91.59 E-value: 7.04e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 209 SALPRelkpLGQALNKMH---HALVKDFErlsQFADDLAHELRTPINALlgQNQVTLSQTRSIAEyQKTIAGNIEELENi 285
Cdd:PRK10604 189 SSLER----LGVAFNQMAdniNALIASKK---QLIDGIAHELRTPLVRL--RYRLEMSDNLSAAE-SQALNRDIGQLEA- 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 286 srLTENILFLARADKNNVLVKLDSLSLNKEVENLLDYLEYLSDEKEI-CFKVECNQQIFADKILLQRMLSNLIVNAIRYS 364
Cdd:PRK10604 258 --LIEELLTYARLDRPQNELHLSEPDLPAWLSTHLADIQAVTPEKTVrLDTPHQGDYGALDMRLMERVLDNLLNNALRYA 335
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15831960 365 peKSRIHITSFLDTNSY-LNIDIASPGAKINEPEKLFRRFWRGDNSRH--SVGQGLGLSLVKAIAELHGGS 432
Cdd:PRK10604 336 --HSRVRVSLLLDGNQAcLIVEDDGPGIPPEERERVFEPFVRLDPSRDraTGGCGLGLAIVHSIALAMGGS 404
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
344-452 |
1.97e-19 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 83.19 E-value: 1.97e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 344 ADKILLQRMLSNLIVNAIRYSPEKSRIHITsfLDTNSYLNIDIASPGAKINEP--EKLFRRFWRGDNSRHSvGQGLGLSL 421
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVT--LSEGGELTLTVEDNGIGIPPEdlPRIFEPFSTADKRGGG-GTGLGLSI 77
|
90 100 110
....*....|....*....|....*....|..
gi 15831960 422 VKAIAELHGGSATYHY-LNKHNVFRITLPQRN 452
Cdd:pfam02518 78 VRKLVELLGGTITVESePGGGTTVTLTLPLAQ 109
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
201-431 |
3.45e-19 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 88.49 E-value: 3.45e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 201 DSREPVEVSALPRELKPLGQALNKMHHALVKDFERLSQFADDLAHELRTPINA------LLGQNQVTLSQTRsiaeyqkt 274
Cdd:PRK10755 102 DNLTPIAIHSSTLEIEAVTSALNQLVSRLTSTLDQERLFTADVAHELRTPLAGirlhleLLEKQHHIDVAPL-------- 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 275 iagnIEELENISRLTENILFLARADKNNVLVKLDSLSLNKEV----ENLLDYLEYLSDEKEICFKVECNQQIFADKILLQ 350
Cdd:PRK10755 174 ----IARLDQMMHTVEQLLQLARAGQSFSSGHYQTVKLLEDVilpsQDELSEMLEQRQQTLLLPESAADITVQGDATLLR 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 351 RMLSNLIVNAIRYSPEKSRIHIT-SFLDTNSYLNIDIASPG---AKINEPEKLFRRFwrgdNSRHSvGQGLGLSLVKAIA 426
Cdd:PRK10755 250 LLLRNLVENAHRYSPEGSTITIKlSQEDGGAVLAVEDEGPGideSKCGELSKAFVRM----DSRYG-GIGLGLSIVSRIT 324
|
....*
gi 15831960 427 ELHGG 431
Cdd:PRK10755 325 QLHHG 329
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
243-449 |
1.22e-18 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 87.71 E-value: 1.22e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 243 LAHELR---TPI--NALLGQNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKNnvlvKLDSLSLNKEVE 317
Cdd:COG5000 208 IAHEIKnplTPIqlSAERLRRKLADKLEEDREDLERALDTIIRQVDRLKRIVDEFLDFARLPEP----QLEPVDLNELLR 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 318 NLLDYLEYLSDEKEICFKVECNQQ---IFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDtNSYLNIDIASPGAKIN 394
Cdd:COG5000 284 EVLALYEPALKEKDIRLELDLDPDlpeVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRRE-DGRVRIEVSDNGPGIP 362
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 395 EP--EKLFRRFwrgdNSRHSVGQGLGLSLVKAIAELHGGSATYHylNKHN---VFRITLP 449
Cdd:COG5000 363 EEvlERIFEPF----FTTKPKGTGLGLAIVKKIVEEHGGTIELE--SRPGggtTFTIRLP 416
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
243-450 |
1.76e-18 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 88.55 E-value: 1.76e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 243 LAHELRTPINALLGQNQV-TLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLSLNKEVENLLD 321
Cdd:PRK10490 671 LSHDLRTPLTVLFGQAEIlTLDLASEGSPHARQASEIRQQVLNTTRLVNNLLDMARIQSGGFNLRKEWLTLEEVVGSALQ 750
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 322 YLEYLSDEKEIcfKVECNQQ---IFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDTNSyLNIDI--ASPGAKINEP 396
Cdd:PRK10490 751 MLEPGLSGHPI--NLSLPEPltlIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGER-LQLDVwdNGPGIPPGQE 827
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 15831960 397 EKLFRRFWRGDNSRHSVGQGLGLSLVKAIAELHGGSATYHylNKHN---VFRITLPQ 450
Cdd:PRK10490 828 QLIFDKFARGNKESAIPGVGLGLAICRAIVEVHGGTIWAE--NRPEggaCFRVTLPL 882
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
214-451 |
4.68e-18 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 86.23 E-value: 4.68e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 214 ELKPLGQALNKMHHAL------VKDFERLSQ-FADDLAHELRTPINA------LLGQNQVTL-SQTRSIAEYQKTiagni 279
Cdd:NF040691 242 DLARLARSFNQMADSLqrqirqLEELSRLQQrFVSDVSHELRTPLTTirmaadVIHDSRDDFdPATARSAELLHT----- 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 280 eELENISRLTENILFLARADKNNVLVKLDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQQIF---ADKILLQRMLSNL 356
Cdd:NF040691 317 -ELDRFESLLSDLLEISRFDAGAAELDVEPVDLRPLVRRVVDALRQLAERAGVELRVDAPGTPVvaeVDPRRVERVLRNL 395
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 357 IVNAIRYSpEKSRIHITsfLDTNsYLNIDIA----SPGAKINEPEKLFRRFWRGDNSR--HSVGQGLGLSLVKAIAELHG 430
Cdd:NF040691 396 VVNAIEHG-EGKPVVVT--VAQD-DTAVAVTvrdhGVGLKPGEVALVFDRFWRADPARarTTGGTGLGLAIALEDARLHG 471
|
250 260
....*....|....*....|....*..
gi 15831960 431 GsatyhYLNKHNV------FRITLPQR 451
Cdd:NF040691 472 G-----WLEAWGRpgqgsqFRLTLPRV 493
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
201-431 |
2.18e-17 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 83.03 E-value: 2.18e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 201 DSREPVE-VSALPRELK------PLGqalNKMHHALVKDFERLSQ-------FADDLAHELRTPINALLGQNQvTLSQTR 266
Cdd:TIGR02966 68 RFSEPLElPSPINSERVleiriaPYG---EEQKLLVARDVTRLRRleqmrrdFVANVSHELRTPLTVLRGYLE-TLADGP 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 267 SI--AEYQKTIAGNIEELENISRLTENILFLAR-----ADKNNVLVKLDSLslnkeVENLLDYLEYLSDEKE--ICFKVE 337
Cdd:TIGR02966 144 DEdpEEWNRALEIMLEQSQRMQSLVEDLLTLSRlesaaSPLEDEPVDMPAL-----LDHLRDEAEALSQGKNhqITFEID 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 338 CNQQIFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDtNSYLNIDIASPGAKInEPE---KLFRRFWRGD--NSRHS 412
Cdd:TIGR02966 219 GGVDVLGDEDELRSAFSNLVSNAIKYTPEGGTITVRWRRD-GGGAEFSVTDTGIGI-APEhlpRLTERFYRVDksRSRDT 296
|
250
....*....|....*....
gi 15831960 413 VGQGLGLSLVKAIAELHGG 431
Cdd:TIGR02966 297 GGTGLGLAIVKHVLSRHHA 315
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
207-449 |
7.47e-17 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 81.77 E-value: 7.47e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 207 EVSALPRELKPLGQALNKMHHAlvkdfERLS---QFADDLAHELRTPINALLGQNQV---TLSQTRSIAEYQKTIAGNIE 280
Cdd:COG4191 115 DITELERAEEELRELQEQLVQS-----EKLAalgELAAGIAHEINNPLAAILGNAELlrrRLEDEPDPEELREALERILE 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 281 ELENISRLTENILFLARADKnnvlVKLDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQ---QIFADKILLQRMLSNLI 357
Cdd:COG4191 190 GAERAAEIVRSLRAFSRRDE----EEREPVDLNELIDEALELLRPRLKARGIEVELDLPPdlpPVLGDPGQLEQVLLNLL 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 358 VNAIRYSPEKS--RIHITSFLDTNsYLNIDIASPGAKINEP--EKLFRRFW----RGDnsrhsvGQGLGLSLVKAIAELH 429
Cdd:COG4191 266 INAIDAMEEGEggRITISTRREGD-YVVISVRDNGPGIPPEvlERIFEPFFttkpVGK------GTGLGLSISYGIVEKH 338
|
250 260
....*....|....*....|.
gi 15831960 430 GGSATYHY-LNKHNVFRITLP 449
Cdd:COG4191 339 GGRIEVESePGGGTTFTITLP 359
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
178-432 |
1.38e-16 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 81.60 E-value: 1.38e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 178 LLIRTGLREIKKLSGVTEALNYNDSREPVEVSAlPRELKPLGQALNKMHHALVKDFERLSQFADDLAHELRTPINALLG- 256
Cdd:PRK10549 183 LLARGLLAPVKRLVEGTHKLAAGDFTTRVTPTS-RDELGRLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRGe 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 257 ----QNQVTLSQTRSIAEYQKtiagnieELENISRLTENILFLARADknnvlvkLDSLSLNKEVENLLDYLE-------- 324
Cdd:PRK10549 262 leaiQDGVRKFTPESVASLQA-------EVGTLTKLVDDLHQLSLSD-------EGALAYRKTPVDLVPLLEvaggafre 327
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 325 -YLSDEKEICFKVECNQQIFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDTNSY-LNIDIASPGAKINEPEKLFRR 402
Cdd:PRK10549 328 rFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLrLTFADSAPGVSDEQLQKLFER 407
|
250 260 270
....*....|....*....|....*....|..
gi 15831960 403 FWRGDNSRH--SVGQGLGLSLVKAIAELHGGS 432
Cdd:PRK10549 408 FYRTEGSRNraSGGSGLGLAICLNIVEAHNGR 439
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
243-450 |
7.91e-16 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 78.50 E-value: 7.91e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 243 LAHELRTPINALLGQNQVTLSqtrSIAEYQKTIAGN-IEELENISRLTENILFLARADKNNVLVKLDSLSLNKEVENLLD 321
Cdd:NF012226 145 IAHELRTPITILQGRLQGILD---GVFEPDPALFKSlLNQVEGLSHLVEDLRTLSLVENQQLRLNYESVDLKDSIEKVLK 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 322 YLEYLSDEKEICFKVE-CNQQIFADKILLQRMLSNLIVNAIRYSpEKSRIHITSFLDTNSY-LNIDIASPGAKINEPEKL 399
Cdd:NF012226 222 MFEDRLEQAQLTIVLNlTATPVFCDRRRIEQVLIALIDNAIRYA-NAGKLKISSSVIQDDWiLQIEDEGPGIAEEYQQDL 300
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 15831960 400 FRRFWRGDNSRHSV--GQGLGLSLVKAIAELHGGSATYHYLNKHNVFRITLPQ 450
Cdd:NF012226 301 FNPFFRLEQSRNKEfgGTGLGLAVVHAIVIAHKGSIEYSNSQGNSVFTIKLPA 353
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
234-449 |
9.38e-15 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 76.55 E-value: 9.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 234 ERLS---QFADDLAHELRTPINALLGQNQVTLSQTRSIaEYQKTIAGNIEELENISRLTENILFLARADKnnvlVKLDSL 310
Cdd:PRK11360 385 ERLAalgELVAGVAHEIRNPLTAIRGYVQIWRQQTSDP-PSQEYLSVVLREVDRLNKVIDQLLEFSRPRE----SQWQPV 459
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 311 SLNKEVENLLDYLEYLSDEKEICFKVECNQQ---IFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDTNSYLNIDIA 387
Cdd:PRK11360 460 SLNALVEEVLQLFQTAGVQARVDFETELDNElppIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSDGQVAVSIE 539
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15831960 388 SPGAKInEPE---KLFRRFWrgdnSRHSVGQGLGLSLVKAIAELHGGSATYH-YLNKHNVFRITLP 449
Cdd:PRK11360 540 DNGCGI-DPEllkKIFDPFF----TTKAKGTGLGLALSQRIINAHGGDIEVEsEPGVGTTFTLYLP 600
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-432 |
1.36e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 69.80 E-value: 1.36e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 345 DKILLQRMLSNLIVNAIRYSPEKSRIHI-TSFLDTNSYLNIDIASPGAKINEPEKLFRRFWRGDNSRH--SVGQGLGLSL 421
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIrAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNraSGGSGLGLAI 80
|
90
....*....|.
gi 15831960 422 VKAIAELHGGS 432
Cdd:cd16946 81 CHNIALAHGGT 91
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
239-451 |
7.19e-14 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 73.12 E-value: 7.19e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 239 FADdLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKNnvlvklDSLSLNKEVE- 317
Cdd:PRK11006 208 FAN-VSHELRTPLTVLQGYLEMMQDQPLEGALREKALHTMREQTQRMEGLVKQLLTLSKIEAA------PTIDLNEKVDv 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 318 -NLLDYLEY----LSDEK-EICFKVECNQQIFADKILLQRMLSNLIVNAIRYSPEKSRIHItSFLDTNSYLNIDIASPGA 391
Cdd:PRK11006 281 pMMLRVLEReaqtLSQGKhTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITV-RWQRVPQGAEFSVEDNGP 359
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15831960 392 KInEPEKLFR---RFWRGDN--SRHSVGQGLGLSLVKaiaelhggsatyHYLNKHN-------------VFRITLPQR 451
Cdd:PRK11006 360 GI-APEHIPRlteRFYRVDKarSRQTGGSGLGLAIVK------------HALSHHDsrleiesevgkgtRFSFVLPER 424
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-434 |
7.77e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 67.09 E-value: 7.77e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 349 LQRMLSNLIVNAIRYSpeKSRIHITSFLDTNsYLNIDIASPGAKINEPE--KLFRRFWRGDNSRHSVGQGLGLSLVKAIA 426
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGN-RTRIQVLDNGPGIAPEEvdELFQPFYRGDNARGTSGTGLGLAIVQRIS 77
|
....*...
gi 15831960 427 ELHGGSAT 434
Cdd:cd16950 78 DAHGGSLT 85
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
212-432 |
1.13e-13 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 72.66 E-value: 1.13e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 212 PRELKPLGQALNKMHHAL---VKDFERLsqfADDLAHELRTPI------NALLgqnqvtlsqTRSIAEYQKT--IAGNIE 280
Cdd:PRK09470 219 PQEFRQAGASFNQMVTALermMTSQQRL---LSDISHELRTPLtrlqlaTALL---------RRRQGESKELerIETEAQ 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 281 ELEN-ISRLteniLFLARADKNNVLVKlDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQQ---IFADKILLQRMLSNL 356
Cdd:PRK09470 287 RLDSmINDL----LVLSRNQQKNHLER-ETFKANSLWSEVLEDAKFEAEQMGKSLTVSAPPGpwpINGNPNALASALENI 361
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 357 IVNAIRYSpeKSRIHItSFLDTNSYLNIDIASPGAKINEPE--KLFRRFWRGDNS--RHSVGQGLGLSLVKAIAELHGGS 432
Cdd:PRK09470 362 VRNALRYS--HTKIEV-AFSVDKDGLTITVDDDGPGVPEEEreQIFRPFYRVDEArdRESGGTGLGLAIVENAIQQHRGW 438
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
236-449 |
1.72e-13 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 71.42 E-value: 1.72e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 236 LSQFADDLAHELRTPINALLGQNQVtLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKnnvlVKLDSLSLNKE 315
Cdd:COG3852 135 VGELAAGLAHEIRNPLTGIRGAAQL-LERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRP----PEREPVNLHEV 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 316 VENLLDYLEYLSDeKEICFKVECNQ---QIFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDTNS---------YLN 383
Cdd:COG3852 210 LERVLELLRAEAP-KNIRIVRDYDPslpEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQVtlgglrprlYVR 288
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15831960 384 IDIAS--PG------AKINEPekLFrrfwrgdnSRHSVGQGLGLSLVKAIAELHGGSATYH-YLNKHNVFRITLP 449
Cdd:COG3852 289 IEVIDngPGipeeilDRIFEP--FF--------TTKEKGTGLGLAIVQKIVEQHGGTIEVEsEPGKGTTFRIYLP 353
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
329-432 |
2.00e-13 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 71.87 E-value: 2.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 329 EKEICFKV-ECNQQIFADKILLQRMLSNLIVNAIRYSpeKSRIHITSFLDTNS-YLNIDIASPGAKINEPEKLFRRFWRG 406
Cdd:PRK09467 311 EREIETALqPGPIEVPMNPIAIKRALANLVVNAARYG--NGWIKVSSGTEGKRaWFQVEDDGPGIPPEQLKHLFQPFTRG 388
|
90 100
....*....|....*....|....*.
gi 15831960 407 DNSRHSVGQGLGLSLVKAIAELHGGS 432
Cdd:PRK09467 389 DSARGSSGTGLGLAIVKRIVDQHNGK 414
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-449 |
3.45e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 65.42 E-value: 3.45e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 349 LQRMLSNLIVNAIRYSPEKsrIHITSFLDTNS-YLNIDIASPGAKINEPEKLFRRFWRGDNSR--HSVGQGLGLSLVKAI 425
Cdd:cd16949 1 LARALENVLRNALRYSPSK--ILLDISQDGDQwTITITDDGPGVPEDQLEQIFLPFYRVDSARdrESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*.
gi 15831960 426 AELHGGS--ATYHYLNKHNVfRITLP 449
Cdd:cd16949 79 IEQHGGKikASNRKPGGLRV-RIWLP 103
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-434 |
4.72e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 65.18 E-value: 4.72e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 345 DKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDTNsYLNIDIASPGAKINEP--EKLFRRFWRGDNSRHSVGQ-GLGLSL 421
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEE-YLYFEIWDNGHGFSEQdlKKALELFYRDDTSRRSGGHyGMGLYI 79
|
90
....*....|...
gi 15831960 422 VKAIAELHGGSAT 434
Cdd:cd16975 80 AKNLVEKHGGSLI 92
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
243-431 |
1.36e-12 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 68.82 E-value: 1.36e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 243 LAHELRTPINAL--------LGQNQ-VTLSQTRSIAEYQKTIAgniEELENISRLTENILFLARAdKNNVL----VKLDS 309
Cdd:PRK09303 158 LAHDLRTPLTAAslaletleLGQIDeDTELKPALIEQLQDQAR---RQLEEIERLITDLLEVGRT-RWEALrfnpQKLDL 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 310 LSLNKEVenLLDYLEYLSdEKEICFKVECNQQI---FADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDTNSYLNIDI 386
Cdd:PRK09303 234 GSLCQEV--ILELEKRWL-AKSLEIQTDIPSDLpsvYADQERIRQVLLNLLDNAIKYTPEGGTITLSMLHRTTQKVQVSI 310
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 15831960 387 AS--PGAKINEPEKLFRRFWRGDNSRHSVGQGLGLSLVKAIAELHGG 431
Cdd:PRK09303 311 CDtgPGIPEEEQERIFEDRVRLPRDEGTEGYGIGLSVCRRIVRVHYG 357
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
344-436 |
2.61e-12 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 63.28 E-value: 2.61e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 344 ADKIllQRMLSNLIVNAIRYSPEKSRIH-ITSFLDTNSYL-NIDIASPGAKINEPEKLFRRFWRG--DNSRHSVGQGLGL 419
Cdd:cd16925 2 AEKY--ERVVLNLLSNAFKFTPDGGRIRcILEKFRLNRFLlTVSDSGPGIPPNLREEIFERFRQGdgSSTRAHGGTGLGL 79
|
90
....*....|....*..
gi 15831960 420 SLVKAIAELHGGSATYH 436
Cdd:cd16925 80 SIVKEFVELHGGTVTVS 96
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
243-432 |
1.68e-11 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 66.25 E-value: 1.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 243 LAHELRTPINAL-----LGQNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENilFLARADknnvlVKLDSLSLNKEVE 317
Cdd:COG4192 440 LAHELNQPLNAMsmylfSAKKALEQENYAQLPTSLDKIEGLIERMDKIIKSLRQ--FSRKSD-----TPLQPVDLRQVIE 512
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 318 NLLDYLEYLSDEKEICFKVECNQQIFADKILLQRMLSNLIVNAIRYSPEKSRIHItSFLDTNSYLNIDIASPGAKINEPE 397
Cdd:COG4192 513 QAWELVESRAKPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISV-DLLSNAENLRVAISDNGNGWPLVD 591
|
170 180 190
....*....|....*....|....*....|....*
gi 15831960 398 KLFRRFwrgdNSRHSVGQGLGLSLVKAIAELHGGS 432
Cdd:COG4192 592 KLFTPF----TTTKEVGLGLGLSICRSIMQQFGGD 622
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
245-431 |
2.26e-11 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 65.93 E-value: 2.26e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 245 HELRTPinallgqnqvtLSQTRSIAE------YQ-KTIAGNI-----EELENISRLTENILFLARADKNNVLVKLDSLSL 312
Cdd:NF033092 381 HELRTP-----------LTTMRSYLEaladgaWKdPELAPRFlgvtqNETERMIRLVNDLLQLSRMDSKDYKLNKEWVNF 449
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 313 NKEVENLLDYLEYLSDEKEICFKVEC-NQQIFA----DKIllQRMLSNLIVNAIRYSPEKSRIHItSFLDTNSYLNIDIA 387
Cdd:NF033092 450 NEFFNYIIDRFEMILKNKNITFKREFpKRDLWVeidtDKI--TQVLDNIISNAIKYSPEGGTITF-RLLETHNRIIISIS 526
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 15831960 388 SPGAKI--NEPEKLFRRFWRGDN--SRHSVGQGLGLSLVKAIAELHGG 431
Cdd:NF033092 527 DQGLGIpkKDLDKIFDRFYRVDKarSRKMGGTGLGLAIAKEVVEAHGG 574
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-433 |
4.83e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 59.37 E-value: 4.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 349 LQRMLSNLIVNAIRYSpeKSRIHITSFLDTNS-YLNIDIASPGAKINEPEKLFRRFWRGDNSR--HSVGQGLGLSLVKAI 425
Cdd:cd16939 1 MARALDNLLRNALRYA--HRTVRIALLVSGGRlTLIVEDDGPGIPAAARERVFEPFVRLDPSRdrATGGFGLGLAIVHRV 78
|
....*...
gi 15831960 426 AELHGGSA 433
Cdd:cd16939 79 ALWHGGHV 86
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
234-297 |
5.05e-11 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 57.99 E-value: 5.05e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15831960 234 ERLSQFADDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENILFLAR 297
Cdd:cd00082 2 QAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
334-448 |
2.21e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 58.29 E-value: 2.21e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 334 FKVECN---QQIFA--DKILLQRMLSNLIVNAIRYSPEKSRIHITSFLD-TNSYlnIDIASPGAKINEP--EKLFRRFWR 405
Cdd:cd16947 1 FQVEINipdRPIYAnaNTEALQRILKNLISNAIKYGSDGKFLGMTLREDeKHVY--IDIWDKGKGISETekDHVFERLYT 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 15831960 406 GDNSRHSV--GQGLGLSLVKAIAELHGGSAtyhYLNKH----NVFRITL 448
Cdd:cd16947 79 LEDSRNSAkqGNGLGLTITKRLAESMGGSI---YVNSKpyekTVFTVTL 124
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
274-449 |
2.60e-10 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 61.79 E-value: 2.60e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 274 TIAGNIEELEN------ISRLTENIlflaradkNNVLVKLDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQQIFADKI 347
Cdd:COG3290 206 TISGLLQLGEYdealeyIDEISEEL--------QELIDSLLSRIGNPVLAALLLGKAARARERGIDLTIDIDSDLPDLPL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 348 ---LLQRMLSNLIVNAIRYS----PEKSRIHITsFLDTNSYLNIDIASPGAKINePEKLFRRFWRGDNSRHSVGQGLGLS 420
Cdd:COG3290 278 sdtDLVTILGNLLDNAIEAVeklpEEERRVELS-IRDDGDELVIEVEDSGPGIP-EELLEKIFERGFSTKLGEGRGLGLA 355
|
170 180 190
....*....|....*....|....*....|
gi 15831960 421 LVKAIAELHGGSATYHYLNKHN-VFRITLP 449
Cdd:COG3290 356 LVKQIVEKYGGTIEVESEEGEGtVFTVRLP 385
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
234-449 |
3.72e-10 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 61.91 E-value: 3.72e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 234 ERLS---QFADDLAHELRTPINALLGQNQVTLSqtrSIAEYQKTIAGNI-EELENISRLTENILFLARADKnnvlVKLDS 309
Cdd:COG5809 265 EKLSvvgELAAGIAHEIRNPLTSLKGFIQLLKD---TIDEEQKTYLDIMlSELDRIESIISEFLVLAKPQA----IKYEP 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 310 LSLNKEVENLLDYLEYLSDEKEICFKVECNQQ---IFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDTNSYLNIDI 386
Cdd:COG5809 338 KDLNTLIEEVIPLLQPQALLKNVQIELELEDDipdILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDDDKVVISV 417
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15831960 387 ASPGAKINEP--EKLFRRFWrgdnSRHSVGQGLGLSLVKAIAELHGGSATYHY-LNKHNVFRITLP 449
Cdd:COG5809 418 TDEGCGIPEErlKKLGEPFY----TTKEKGTGLGLMVSYKIIEEHGGKITVESeVGKGTTFSITLP 479
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
349-432 |
4.58e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 56.73 E-value: 4.58e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 349 LQRMLSNLIVNAIRYSPE---KSRIHITSFLDTNSYLNIDIASPGAKINEPE--KLFRRFWRGDNS--RHSVGQGLGLSL 421
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEgevTLRVSLEEEEEDGVQLRFSVEDTGIGIPEEQqaRLFEPFSQADSSttRKYGGTGLGLAI 80
|
90
....*....|.
gi 15831960 422 VKAIAELHGGS 432
Cdd:cd16922 81 SKKLVELMGGD 91
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
314-435 |
1.84e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 55.72 E-value: 1.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 314 KEVENLLDYLEYLSDEK--EICFKVECNQQIFADKILLQRMLSNLIVNAIRYSPEKSRIHItSFLDTNSYLNIDIASPGA 391
Cdd:cd16954 1 PLLDSLCSALNKVYQRKgvSISLDISPELRFPGERNDLMELLGNLLDNACKWCLEFVEVTA-RQTDGGLHLIVDDDGPGV 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 15831960 392 KINEPEKLFRRFWRGDNSRHsvGQGLGLSLVKAIAELHGGSATY 435
Cdd:cd16954 80 PESQRSKIFQRGQRLDEQRP--GQGLGLAIAKEIVEQYGGELSL 121
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
235-299 |
3.91e-09 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 52.60 E-value: 3.91e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15831960 235 RLSQFADDLAHELRTPINALLGQNQVtLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARAD 299
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLEL-LRDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIE 64
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-444 |
5.96e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 53.73 E-value: 5.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 349 LQRMLSNLIVNAIRYSPEKS-RIHITSFLDTNSY-LNIDIASPGAKINEPEKLFRRFWRGDNSRHSVGQ--GLGLSLVKA 424
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDTgRITVSAMPTGKMVtISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQhsGLGLSISRQ 80
|
90 100
....*....|....*....|
gi 15831960 425 IAELHGGSATYHYLNKHNVF 444
Cdd:cd16953 81 IIEAHGGISVAENHNQPGQV 100
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
237-449 |
8.49e-09 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 58.21 E-value: 8.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 237 SQFADDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLSLNKEV 316
Cdd:PRK09959 713 SQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPTLV 792
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 317 ENLLDYLEYLSDEKEICfkVECNQQiFADKILL-------QRMLSNLIVNAIRYSPEKSrIHITSFL----DTNSYLNID 385
Cdd:PRK09959 793 QNTCHSFGAIAASKSIA--LSCSST-FPDHYLVkidpqafKQVLSNLLSNALKFTTEGA-VKITTSLghidDNHAVIKMT 868
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15831960 386 IASPGAKINEPE--KLFRRFWRGDNSRHSVGQGLGLSLVKA-IAELHGGSATYHYLNKHNVFRITLP 449
Cdd:PRK09959 869 IMDSGSGLSQEEqqQLFKRYSQTSAGRQQTGSGLGLMICKElIKNMQGDLSLESHPGIGTTFTITIP 935
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-434 |
1.94e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 52.08 E-value: 1.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 345 DKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDTNSyLNIDIASPGAKINE--PEKLFRRFW---RGDNSRHSvgQGLGL 419
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEG-IELLVFDEGSGIPDyaLNRVFERFYslpRPHSGQKS--TGLGL 77
|
90
....*....|....*
gi 15831960 420 SLVKAIAELHGGSAT 434
Cdd:cd16945 78 AFVQEVAQLHGGRIT 92
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
223-449 |
1.95e-08 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 56.28 E-value: 1.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 223 NKMHHALVKDFERLS---QFADDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIagnIEELENISRLTENILFLARaD 299
Cdd:COG5805 271 KKEAEELMARSEKLSiagQLAAGIAHEIRNPLTSIKGFLQLLQPGIEDKEEYFDIM---LSELDRIESIISEFLALAK-P 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 300 KNNVLVKLDSLSLNKEVENLLdYLEYLSDEKEICFKV-ECNQQIFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDt 378
Cdd:COG5805 347 QAVNKEKENINELIQDVVTLL-ETEAILHNIQIRLELlDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEE- 424
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15831960 379 NSYLNIDIASPGAKINEP--EKLFRRFWrgdnSRHSVGQGLGLSLVKAIAELHGGsaTYHYLNKHN---VFRITLP 449
Cdd:COG5805 425 DNSVIIRVIDEGIGIPEErlKKLGEPFF----TTKEKGTGLGLMVSYKIIENHNG--TIDIDSKVGkgtTFTITLP 494
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
235-299 |
2.94e-08 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 50.26 E-value: 2.94e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15831960 235 RLSQFADDLAHELRTPINALLGQNQVTLSQTRSiAEYQKTIAGNIEELENISRLTENILFLARAD 299
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELS-EEQREYLETILREAERLLRLINDLLDLSRIE 64
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
184-432 |
1.08e-07 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 53.87 E-value: 1.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 184 LREIKKLSGVTEALNyNDSREPVEVSAlPRELKPLGQALNKMhhaLVKDFERLSQFA---DDLAHELRTPINALlgqnQV 260
Cdd:PRK10815 216 LRPIEALAKQVRELE-EGEREQLDPNP-PRELTSLVRNLNRL---LKNERERYTKYRttlTDLTHSLKTPLAVL----QS 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 261 TLsqtRSIAEYQKTiagNIEE-----LENISRLTENI-LFLARAD---KNNVLVK--------LDSL--SLNK-----EV 316
Cdd:PRK10815 287 TL---RSLRSGKQM---SVEQaepimLEQISRISQQIgYYLHRASmrsEHNLLSRelhsvaplLDNLtsALNKvyqrkGV 360
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 317 ENLLDYleylsdEKEICFKVECNQqifadkilLQRMLSNLIVNAIRYSPEksRIHITSFLDTNS-YLNIDIASPGAKINE 395
Cdd:PRK10815 361 NITLDI------SPEITFVGEKND--------FMEVMGNVLDNACKYCLE--FVEISARQTDEHlHIVVEDDGPGIPESK 424
|
250 260 270
....*....|....*....|....*....|....*..
gi 15831960 396 PEKLFRRFWRGDNSRHsvGQGLGLSLVKAIAELHGGS 432
Cdd:PRK10815 425 RELIFDRGQRADTLRP--GQGLGLSVAREITEQYEGK 459
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-449 |
1.41e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 49.63 E-value: 1.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 349 LQRMLSNLIVNAIRYSPEK--SRIHITSFLDTNSYLnIDIASPGAKINEP--EKLFRRFWRGDNSRHSVGQGLGLSLVKA 424
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrpPRIEVGAEDVGEEWT-FYVRDNGIGIDPEyaEKVFGIFQRLHSREEYEGTGVGLAIVRK 79
|
90 100
....*....|....*....|....*.
gi 15831960 425 IAELHGGSATYHY-LNKHNVFRITLP 449
Cdd:cd16921 80 IIERHGGRIWLESePGEGTTFYFTLP 105
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-429 |
4.05e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 48.35 E-value: 4.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 349 LQRMLSNLIVNAIRYSPEKSRIHIT-SFLDTNSYLNIDIASPGAKINEPEKLFRRFWRGD--NSRHSVGQGLGLSLVKAI 425
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRwSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDieRCRNTGGTGLGLAIVKHV 80
|
....
gi 15831960 426 AELH 429
Cdd:cd16952 81 MSRH 84
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-449 |
5.37e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 48.05 E-value: 5.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 345 DKILLQRMLSNLIVNAIRYSPEKSRIHITSFlDTNSYLNIDIASPGAKINEPE--KLFRRFWRGDNSRHSV-GQGLGLSL 421
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSE-TNEQGVVLSIKDFGIGIPEEDlpRVFDKGFTGENGRNFQeSTGMGLYL 80
|
90 100 110
....*....|....*....|....*....|
gi 15831960 422 VKAIAE--LHGGSATYHYlNKHNVFRITLP 449
Cdd:cd16948 81 VKKLCDklGHKIDVESEV-GEGTTFTITFP 109
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
237-449 |
5.63e-07 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 52.16 E-value: 5.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 237 SQFADDLAHELRTPINALLG------QNQVTLSQTrsiaEYQKTI---AGN----IEELENISRL------TENILFLAR 297
Cdd:PRK11107 294 SEFLANMSHELRTPLNGVIGftrqtlKTPLTPTQR----DYLQTIersANNllaiINDILDFSKLeagklvLENIPFSLR 369
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 298 AdknnvlvkldslSLNkEVENLldyLEYLSDEKEICFKVECNQQI----FADKILLQRMLSNLIVNAIRYSPEKS---RI 370
Cdd:PRK11107 370 E------------TLD-EVVTL---LAHSAHEKGLELTLNIDPDVpdnvIGDPLRLQQIITNLVGNAIKFTESGNidiLV 433
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 371 HITSFLDTNSYLNIDIASPGAKINEP--EKLFRRFWRGDNS---RHSvGQGLGLSLVKAIAELHGGSATYHY-LNKHNVF 444
Cdd:PRK11107 434 ELRALSNTKVQLEVQIRDTGIGISERqqSQLFQAFRQADASisrRHG-GTGLGLVITQKLVNEMGGDISFHSqPNRGSTF 512
|
....*
gi 15831960 445 RITLP 449
Cdd:PRK11107 513 WFHLP 517
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
239-431 |
2.08e-06 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 50.32 E-value: 2.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 239 FADDLAHELRTPINALLGQNQVTLsQTRSIAE---YQKTIAGNIEELENIsrlTENILFLARADKNNvlVKLDSLSLNke 315
Cdd:PRK11091 286 FISTISHELRTPLNGIVGLSRILL-DTELTAEqrkYLKTIHVSAITLGNI---FNDIIDMDKMERRK--LQLDNQPID-- 357
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 316 VENLLDYLEYLS----DEKEICFKVECN----QQIFADKILLQRMLSNLIVNAIRYSpEKSRIHITSFLDTNSYLNIDIA 387
Cdd:PRK11091 358 FTDFLADLENLSglqaEQKGLRFDLEPLlplpHKVITDGTRLRQILWNLISNAVKFT-QQGGVTVRVRYEEGDMLTFEVE 436
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 15831960 388 SPGAKI--NEPEKLFRRFWR---GDNSRHSVGQGLGLSLVKAIAELHGG 431
Cdd:PRK11091 437 DSGIGIpeDELDKIFAMYYQvkdSHGGKPATGTGIGLAVSKRLAQAMGG 485
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
176-451 |
2.38e-06 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 49.90 E-value: 2.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 176 SPLLIRTGLREIKKLSGVTEALNYNdsrepveVSALPR---ELKPLGQALNKMHHALV-----------KDFERLSQFAD 241
Cdd:PRK11466 377 SPFPETAGVRELDTIGRLMDAFRSN-------VHALNRhreQLAAQVKARTAELQELViehrqaraeaeKASQAKSAFLA 449
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 242 DLAHELRTPINALLGQNQVtLSQTRSIAEYQKTIAGNIEELENISRLTENILFLA--RADKNNVLVKLDSLSLNKEVENL 319
Cdd:PRK11466 450 AMSHEIRTPLYGILGTAQL-LADNPALNAQRDDLRAITDSGESLLTILNDILDYSaiEAGGKNVSVSDEPFEPRPLLEST 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 320 LDYLEYLSDEKEICFKVECNQQIFA----DKILLQRMLSNLIVNAIRYSpEKSRIHITSFLDTNSYLnIDIASPGAKINE 395
Cdd:PRK11466 529 LQLMSGRVKGRPIRLATDIADDLPTalmgDPRRIRQVITNLLSNALRFT-DEGSIVLRSRTDGEQWL-VEVEDSGCGIDP 606
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 15831960 396 PEK--LFRRFWRGDNSRHsvGQGLGLSLVKAIAELHGGSATY-HYLNKHNVFRITLPQR 451
Cdd:PRK11466 607 AKLaeIFQPFVQVSGKRG--GTGLGLTISSRLAQAMGGELSAtSTPEVGSCFCLRLPLR 663
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
352-434 |
4.23e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 45.36 E-value: 4.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 352 MLSNLIVNAI----RYSPEKSRIHItSFLDTNSYLNIDIASPGAKInEPEKLFRRFWRGDNSRHSVGQGLGLSLVKAIAE 427
Cdd:cd16915 4 IVGNLIDNALdalaATGAPNKQVEV-FLRDEGDDLVIEVRDTGPGI-APELRDKVFERGVSTKGQGERGIGLALVRQSVE 81
|
....*..
gi 15831960 428 LHGGSAT 434
Cdd:cd16915 82 RLGGSIT 88
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
236-449 |
8.42e-06 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 47.86 E-value: 8.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 236 LSQFADDLAHELRTPinallgqnqvtLSQTRSIAEY--QKTIAGN---------IEELENISRLTENILFLARADKnnvl 304
Cdd:PRK10364 237 LGHLAAGVAHEIRNP-----------LSSIKGLAKYfaERAPAGGeahqlaqvmAKEADRLNRVVSELLELVKPTH---- 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 305 VKLDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQQ---IFADKILLQRMLSNLIVNAIRYSPEKSRIHIT-SFLDTNs 380
Cdd:PRK10364 302 LALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTlpeIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTaSESGAG- 380
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15831960 381 yLNIDIASPGAKI--NEPEKLFRRFWRGDNSrhsvGQGLGLSLVKAIAELHGGSATYHYL-NKHNVFRITLP 449
Cdd:PRK10364 381 -VKISVTDSGKGIaaDQLEAIFTPYFTTKAE----GTGLGLAVVHNIVEQHGGTIQVASQeGKGATFTLWLP 447
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-449 |
1.79e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 43.54 E-value: 1.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 349 LQRMLSNLIVNAIR----YSPEKSRIHITSFLDTNSYLNIDIASPGAKI--NEPEKLFRRFWrgdnSRHSVGQGLGLSLV 422
Cdd:cd16920 1 IQQVLINLVRNGIEamseGGCERRELTIRTSPADDRAVTISVKDTGPGIaeEVAGQLFDPFY----TTKSEGLGMGLSIC 76
|
90 100
....*....|....*....|....*...
gi 15831960 423 KAIAELHGGSATYHYLNKHN-VFRITLP 449
Cdd:cd16920 77 RSIIEAHGGRLSVESPAGGGaTFQFTLP 104
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
348-449 |
1.48e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 40.87 E-value: 1.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 348 LLQRMLSNLIVNAIRYSPEKSRIHITSFLDTNSYLnIDIASPGAKInEPE---KLFRRFWrgdnSRHSVGQG--LGLSLV 422
Cdd:cd16943 3 QLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVL-IEVEDTGSGI-DPEilgRIFDPFF----TTKPVGEGtgLGLSLS 76
|
90 100
....*....|....*....|....*...
gi 15831960 423 KAIAELHGGS-ATYHYLNKHNVFRITLP 449
Cdd:cd16943 77 YRIIQKHGGTiRVASVPGGGTRFTIILP 104
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
25-449 |
6.03e-04 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 41.93 E-value: 6.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 25 IVWTLYNGLASELKWRDDTTLINRTAQIKQLLIDGVNPDTLPVYFNRMMDVSQDILIIHGDGINKIVNRTNVSDDMLNNI 104
Cdd:COG2972 23 LILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLILLLLLLLLLLLILLLSLLLL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 105 PASETISAAGIYRSIINDTEIDALRINIDEVSPSLTVTVAKLASARHNMLEQYKINSIIICIVAIILCSVLSPLLIRTGL 184
Cdd:COG2972 103 LALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSIT 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 185 REIKKLSGVTEALNYNDSREPVEVSALprELKPLGQALNKMH---HALVKDFERLSQfaddLAHELRtpINALlgQNQV- 260
Cdd:COG2972 183 RPIKRLKKAMKKVEKGDLVRLEVSGND--EIGILARSFNEMVeriKELIEEVYELEL----EKKEAE--LKAL--QAQIn 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 261 ------TLSQTRSIAEyqktiagnIEELENISRLTENILFLARA--DKNNVLVkldslSLNKEVENLLDYLE-----Yls 327
Cdd:COG2972 253 phflfnTLNSIRWLAE--------LEDPEEAEEMLEALSKLLRYslSKGDELV-----TLEEELELIKSYLEiqklrF-- 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 328 dEKEICFKVECNQQIfADKILLQRMLSNLIVNAIRY----SPEKSRIHITSFLDtNSYLNIDIASPGAKINEP--EKLFR 401
Cdd:COG2972 318 -GDRLEVEIEIDEEL-LDLLIPKLILQPLVENAIEHgiepKEGGGTIRISIRKE-GDRLVITVEDNGVGMPEEklEKLLE 394
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 15831960 402 RFwrgdnSRHSVGQGLGLSLVKAIAELHGGSA----TYHYLNKHNVFRITLP 449
Cdd:COG2972 395 EL-----SSKGEGRGIGLRNVRERLKLYYGEEygleIESEPGEGTTVTIRIP 441
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
414-449 |
7.43e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 38.92 E-value: 7.43e-04
10 20 30
....*....|....*....|....*....|....*.
gi 15831960 414 GQGLGLSLVKAIAELHGGSATYHYLNKHNVFRITLP 449
Cdd:cd16918 74 GTGLGLAIAQNIVSQHGGVIECDSQPGHTVFSVSLP 109
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
238-361 |
3.55e-03 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 39.92 E-value: 3.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15831960 238 QFADDLAHELRTPINALlGQNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLSLNKEVE 317
Cdd:PRK10618 452 AFLQNIGDELKQPLQSL-AQLAAQLRQTSDEEQQQPELDQLAEQSDVLVRLVDNIQLLNMLETQDWKPEQELFSLQDLID 530
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 15831960 318 NLLdyLEYLSDEKE------ICFKVECNQQIFADKILLQRMLSNLIVNAI 361
Cdd:PRK10618 531 EVL--PEVLPAIKRkglqllIHNHLKAEQLRIGDRDALRKILLLLLNYAI 578
|
|
| |
