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Conserved domains on  [gi|15833711|ref|NP_312484|]
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transcriptional regulator [Escherichia coli O157:H7 str. Sakai]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 12820790)

AraC family transcriptional regulator containing an AraC family helix-turn-helix (HTH) domain, controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|15808743|9409145|33837749|11282467

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlxA super family cl34854
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 166-268 4.08e-20

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


The actual alignment was detected with superfamily member COG4977:

Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 87.91  E-value: 4.08e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711 166 KAQKLIRTQYHRPLSTALLARELYCNADYLGRVYRRVFHLTLTEAIHRQRVREAEKLLISEARSLTEVAALCGFNDVGYF 245
Cdd:COG4977 214 RAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGSASHF 293

                        90       100
                ....*....|....*....|...
gi 15833711 246 RQIFRKHTGLTPAAWKRRYSKEH 268
Cdd:COG4977 294 RRAFRRRFGVSPSAYRRRFRARA 316
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
25-267 1.87e-19

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


:

Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 85.22  E-value: 1.87e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711  25 RHSARRLESWEIIFVEKGRLTIQEEERIFLVDAGESLLLWPNRQHVGVEDFPADLKFYWLHFEVKAPDNDPRWLTHLSVP 104
Cdd:COG2207  15 ALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGL 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711 105 QQTKVVDPQALVALFRQFLSEQEKHQRTPALEFIVLLILQQLTRDARLDEQADGAGTTLAWKAQKLIRTQYHRPLSTALL 184
Cdd:COG2207  95 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEEL 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711 185 ARELYCNADYLGRVYRRVFHLTLTEAIHRQRVREAEKLLISEARSLTEVAALCGFNDVGYFRQIFRKHTGLTPAAWKRRY 264
Cdd:COG2207 175 ARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRL 254


                ...
gi 15833711 265 SKE 267
Cdd:COG2207 255 RAR 257
 
Name Accession Description Interval E-value
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 166-268 4.08e-20

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 87.91  E-value: 4.08e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711 166 KAQKLIRTQYHRPLSTALLARELYCNADYLGRVYRRVFHLTLTEAIHRQRVREAEKLLISEARSLTEVAALCGFNDVGYF 245
Cdd:COG4977 214 RAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGSASHF 293

                        90       100
                ....*....|....*....|...
gi 15833711 246 RQIFRKHTGLTPAAWKRRYSKEH 268
Cdd:COG4977 294 RRAFRRRFGVSPSAYRRRFRARA 316
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
25-267 1.87e-19

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 85.22  E-value: 1.87e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711  25 RHSARRLESWEIIFVEKGRLTIQEEERIFLVDAGESLLLWPNRQHVGVEDFPADLKFYWLHFEVKAPDNDPRWLTHLSVP 104
Cdd:COG2207  15 ALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGL 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711 105 QQTKVVDPQALVALFRQFLSEQEKHQRTPALEFIVLLILQQLTRDARLDEQADGAGTTLAWKAQKLIRTQYHRPLSTALL 184
Cdd:COG2207  95 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEEL 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711 185 ARELYCNADYLGRVYRRVFHLTLTEAIHRQRVREAEKLLISEARSLTEVAALCGFNDVGYFRQIFRKHTGLTPAAWKRRY 264
Cdd:COG2207 175 ARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRL 254


                ...
gi 15833711 265 SKE 267
Cdd:COG2207 255 RAR 257
HTH_18 pfam12833
Helix-turn-helix domain;
184-263 1.78e-18

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 77.63  E-value: 1.78e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711   184 LARELYCNADYLGRVYRRVFHLTLTEAIHRQRVREAEKLLISE-ARSLTEVAALCGFNDVGYFRQIFRKHTGLTPAAWKR 262
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEDtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 15833711   263 R 263
Cdd:pfam12833  81 R 81
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
178-261 5.78e-18

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 76.44  E-value: 5.78e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711    178 PLSTALLARELYCNADYLGRVYRRVFHLTLTEAIHRQRVREAEKLLISEARSLTEVAALCGFNDVGYFRQIFRKHTGLTP 257
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 15833711    258 AAWK 261
Cdd:smart00342  81 SEYR 84
ftrA PRK09393
transcriptional activator FtrA; Provisional
 171-265 9.85e-10

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 58.05  E-value: 9.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711  171 IRTQYHRPLSTALLARElycnADYLGRVYRRVFH----LTLTEAIHRQRVREAEKLLISEARSLTEVAALCGFNDVGYFR 246
Cdd:PRK09393 227 MRAHLAEPHTVASLAAR----AAMSPRTFLRRFEaatgMTPAEWLLRERLARARDLLESSALSIDQIAERAGFGSEESLR 302

                         90
                 ....*....|....*....
gi 15833711  247 QIFRKHTGLTPAAWKRRYS 265
Cdd:PRK09393 303 HHFRRRAATSPAAYRKRFG 321
AraC_binding pfam02311
AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization ...
 25-131 1.46e-06

AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH) DNA-binding motif pfam00165. This domain is distantly related to the Cupin domain pfam00190.


Pssm-ID: 396749 [Multi-domain]  Cd Length: 134  Bit Score: 46.66  E-value: 1.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711    25 RHSARRLESWEIIFVEKGRLTIQEEERIFLVDAGESLLLWPNRQHVGVEDFPADLKFYWLHFEVKAPDNDPRWLTHLSvP 104
Cdd:pfam02311  15 SFPPHVHDFYVIGYIERGVGRFRLNGRTYHLGPGDLFLLPPGEPHDYEPESEDGWRYRWLYFEPELLERILADISILA-G 93

                          90       100
                  ....*....|....*....|....*..
gi 15833711   105 QQTKVVDPQALVALFRQFLSEQEKHQR 131
Cdd:pfam02311  94 GPLPLLRDPELAALLRALFRLLEEAGR 120
 
Name Accession Description Interval E-value
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 166-268 4.08e-20

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 87.91  E-value: 4.08e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711 166 KAQKLIRTQYHRPLSTALLARELYCNADYLGRVYRRVFHLTLTEAIHRQRVREAEKLLISEARSLTEVAALCGFNDVGYF 245
Cdd:COG4977 214 RAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGSASHF 293

                        90       100
                ....*....|....*....|...
gi 15833711 246 RQIFRKHTGLTPAAWKRRYSKEH 268
Cdd:COG4977 294 RRAFRRRFGVSPSAYRRRFRARA 316
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
25-267 1.87e-19

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 85.22  E-value: 1.87e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711  25 RHSARRLESWEIIFVEKGRLTIQEEERIFLVDAGESLLLWPNRQHVGVEDFPADLKFYWLHFEVKAPDNDPRWLTHLSVP 104
Cdd:COG2207  15 ALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGL 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711 105 QQTKVVDPQALVALFRQFLSEQEKHQRTPALEFIVLLILQQLTRDARLDEQADGAGTTLAWKAQKLIRTQYHRPLSTALL 184
Cdd:COG2207  95 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEEL 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711 185 ARELYCNADYLGRVYRRVFHLTLTEAIHRQRVREAEKLLISEARSLTEVAALCGFNDVGYFRQIFRKHTGLTPAAWKRRY 264
Cdd:COG2207 175 ARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRL 254


                ...
gi 15833711 265 SKE 267
Cdd:COG2207 255 RAR 257
HTH_18 pfam12833
Helix-turn-helix domain;
184-263 1.78e-18

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 77.63  E-value: 1.78e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711   184 LARELYCNADYLGRVYRRVFHLTLTEAIHRQRVREAEKLLISE-ARSLTEVAALCGFNDVGYFRQIFRKHTGLTPAAWKR 262
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEDtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 15833711   263 R 263
Cdd:pfam12833  81 R 81
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
178-261 5.78e-18

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 76.44  E-value: 5.78e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711    178 PLSTALLARELYCNADYLGRVYRRVFHLTLTEAIHRQRVREAEKLLISEARSLTEVAALCGFNDVGYFRQIFRKHTGLTP 257
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 15833711    258 AAWK 261
Cdd:smart00342  81 SEYR 84
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 154-269 1.04e-13

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 70.08  E-value: 1.04e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711 154 EQADGAGTTLAW--KAQKLIRTQYHRPLSTALLARELYCNADYLGRVYRRVFHLTLTEAIHRQRVREAeKLLISEARSLT 231
Cdd:COG2169  74 DLAPGSPPRADLvaRACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRA-RQLLQTGLSVT 152

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15833711 232 EVAALCGFNDVGYFRQIFRKHTGLTPAAWKRRYSKEHI 269
Cdd:COG2169 153 DAAYAAGFGSLSRFYEAFKKLLGMTPSAYRRGGAGAAI 190
ftrA PRK09393
transcriptional activator FtrA; Provisional
 171-265 9.85e-10

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 58.05  E-value: 9.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711  171 IRTQYHRPLSTALLARElycnADYLGRVYRRVFH----LTLTEAIHRQRVREAEKLLISEARSLTEVAALCGFNDVGYFR 246
Cdd:PRK09393 227 MRAHLAEPHTVASLAAR----AAMSPRTFLRRFEaatgMTPAEWLLRERLARARDLLESSALSIDQIAERAGFGSEESLR 302

                         90
                 ....*....|....*....
gi 15833711  247 QIFRKHTGLTPAAWKRRYS 265
Cdd:PRK09393 303 HHFRRRAATSPAAYRKRFG 321
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
195-264 3.04e-08

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 53.37  E-value: 3.04e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711  195 LGRVYRRVFHLTLTEAIHRQRVREAEKLLISEARSLTEVAALCGFNDVGYFRQIFRKHTGLTPAAWKRRY 264
Cdd:PRK13501 209 LKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFSAVFTREAGMTPRDYRQRF 278
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
120-261 3.51e-08

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 53.13  E-value: 3.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711  120 RQFLS--EQEKHQRTPALEFIVLLILQQLTRDAR-----LDEQADGAGTTLAWKAQKLIRTQYHRPLSTALLARELYCNA 192
Cdd:PRK13502 127 RQVINqlEHESNGRDPLANEMAELLFGQLVMTLKrhryaTDDLPATSRETLLDKLITALANSLECPFALDAFCQQEQCSE 206

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15833711  193 DYLGRVYRRVFHLTLTEAIHRQRVREAEKLLISEARSLTEVAALCGFNDVGYFRQIFRKHTGLTPAAWK 261
Cdd:PRK13502 207 RVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVFTRETGMTPSQWR 275
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 180-270 5.97e-08

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 52.62  E-value: 5.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711  180 STALLARELYCNADYLGRVYRR---VFHLTLTEAihrqRVREAEKLLISEARSLTEVAALCGFNDVGYFRQIFRKHTGLT 256
Cdd:PRK09978 160 TLARIASELLMSPSLLKKKLREeetSYSQLLTEC----RMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMT 235

                         90
                 ....*....|....
gi 15833711  257 PAAWKRRYSKEHIN 270
Cdd:PRK09978 236 PTEYQERSAQGLPN 249
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
125-271 2.48e-07

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 50.87  E-value: 2.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711  125 EQEKHQRTPALEFIVLLILQQLT-----RDARLDEQADGAGTTLAWKAQKLIRTQYHRPLSTALLARELYCNADYLGRVY 199
Cdd:PRK13500 164 EHESSQHVPFANEMAELLFGQLVmllnrHRYTSDSLPPTSSETLLDKLITRLAASLKSPFALDKFCDEASCSERVLRQQF 243

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15833711  200 RRVFHLTLTEAIHRQRVREAEKLLISEARSLTEVAALCGFNDVGYFRQIFRKHTGLTPAAWKrryskeHINS 271
Cdd:PRK13500 244 RQQTGMTINQYLRQVRVCHAQYLLQHSRLLISDISTECGFEDSNYFSVVFTRETGMTPSQWR------HLNS 309
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 81-258 3.05e-07

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 50.45  E-value: 3.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711   81 FYWLHFEVKAPDNDPRwLTHLSVPQQTKVvdpqalvALFRQFLSEQEKHQRTP--ALEFIVLLILQQLTRDAR-LDEQAD 157
Cdd:PRK15186 105 FLYEHADFSAPLTKPT-TKHLLAPIETGV-------ARVFNLLHSSNKSQKLSqdKKEYLIRFLLSEFIYEPEaFALFRE 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711  158 GAGTTLAWKAQKLIRTQYHRPLSTALLARELYCNADYLGRVYRRVfHLTLTEAIHRQRVREAEKLLISEARSLTEVAALC 237
Cdd:PRK15186 177 LSQNTLAENIYNIIISDISRKWALKDISDSLYMSCSTLKRKLKQE-NTSFSEVYLNARMNKATKLLRNSEYNITRVAYMC 255

                        170       180
                 ....*....|....*....|.
gi 15833711  238 GFNDVGYFRQIFRKHTGLTPA 258
Cdd:PRK15186 256 GYDSASYFTCVFKKHFKTTPS 276
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
214-268 8.36e-07

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 49.20  E-value: 8.36e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 15833711  214 QRVREAEKLLISEARSLTEVAALCGFNDVGYFRQIFRKHTGLTPAAWKRRYSKEH 268
Cdd:PRK10572 235 QRISRAKLLLQTTRMPIATIGRNVGYDDQLYFSRVFKKCTGASPSEFRARCEEKN 289
AraC_binding pfam02311
AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization ...
 25-131 1.46e-06

AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH) DNA-binding motif pfam00165. This domain is distantly related to the Cupin domain pfam00190.


Pssm-ID: 396749 [Multi-domain]  Cd Length: 134  Bit Score: 46.66  E-value: 1.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711    25 RHSARRLESWEIIFVEKGRLTIQEEERIFLVDAGESLLLWPNRQHVGVEDFPADLKFYWLHFEVKAPDNDPRWLTHLSvP 104
Cdd:pfam02311  15 SFPPHVHDFYVIGYIERGVGRFRLNGRTYHLGPGDLFLLPPGEPHDYEPESEDGWRYRWLYFEPELLERILADISILA-G 93

                          90       100
                  ....*....|....*....|....*..
gi 15833711   105 QQTKVVDPQALVALFRQFLSEQEKHQR 131
Cdd:pfam02311  94 GPLPLLRDPELAALLRALFRLLEEAGR 120
PRK10296 PRK10296
DNA-binding transcriptional regulator ChbR; Provisional
 193-263 3.05e-05

DNA-binding transcriptional regulator ChbR; Provisional


Pssm-ID: 182362 [Multi-domain]  Cd Length: 278  Bit Score: 44.36  E-value: 3.05e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15833711  193 DYLGRVYRRVFHLTLTEAIHRQRVREAEKLLISEARSLTEVAALCGFNDVGYFRQIFRKHTGLTPAAWKRR 263
Cdd:PRK10296 203 EYLTRATRRYYGKTPMQIINEIRINFAKKQLEMTNYSVTDIAFEAGYSSPSLFIKTFKKLTSFTPGSYRKK 273
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
171-263 6.59e-05

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 41.06  E-value: 6.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711  171 IRTQYHRPLSTALLARELYCNADYLGRVYRRVFHLTLTEAIHRQRVREAEKLLISEARSLTEVAALCGFNDVGYFRQIFR 250
Cdd:PRK10219  14 IDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVFR 93

                         90
                 ....*....|...
gi 15833711  251 KHTGLTPAAWKRR 263
Cdd:PRK10219  94 RQFDRTPSDYRHR 106
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 215-260 1.13e-04

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 42.67  E-value: 1.13e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 15833711  215 RVREAEKLLISEARSLTEVAALCGFNDVGYFRQIFRKHTGLTPAAW 260
Cdd:PRK15185 258 RMNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTPSTF 303
PRK15044 PRK15044
transcriptional regulator SirC; Provisional
 166-262 1.95e-04

transcriptional regulator SirC; Provisional


Pssm-ID: 185004 [Multi-domain]  Cd Length: 295  Bit Score: 41.94  E-value: 1.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711  166 KAQKLIRTQYHRPLSTALLARELYCNADYLGRVYRrVFHLTLTEAIHRQRVREAEKLLISEARSLTEVAALCGFNDVGYF 245
Cdd:PRK15044 196 KVYNIIISDLTRKWSQAEVAGKLFMSVSSLKRKLA-AEEVSFSKIYLDARMNQAIKLLRMGAGNISQVATMCGYDTPSYF 274

                         90
                 ....*....|....*..
gi 15833711  246 RQIFRKHTGLTPAAWKR 262
Cdd:PRK15044 275 IAIFKRHFKITPLSFMR 291
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 224-260 2.80e-04

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 37.52  E-value: 2.80e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 15833711   224 ISEARSLTEVAALCGFnDVGYFRQIFRKHTGLTPAAW 260
Cdd:pfam00165   5 LSTNLTIADIADELGF-SRSYFSRLFKKYTGVTPSQY 40
PRK09940 PRK09940
transcriptional regulator YdeO; Provisional
 162-268 3.94e-03

transcriptional regulator YdeO; Provisional


Pssm-ID: 182157 [Multi-domain]  Cd Length: 253  Bit Score: 37.76  E-value: 3.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711  162 TLAWKAQKLIRTQYHRPLSTALLARELYCNADYLGRVYRRVfHLTLTEAIHRQRVREAEKLLISEArSLTEVAALCGFND 241
Cdd:PRK09940 134 SVSGKVRNIVNMKLAHPWKLKDICDCLYISESLLKKKLKQE-QTTFSQILLDARMQHAKNLIRVEG-SVNKIAEQCGYAS 211

                         90       100
                 ....*....|....*....|....*..
gi 15833711  242 VGYFRQIFRKHTGLTPaawkRRYSKEH 268
Cdd:PRK09940 212 TSYFIYAFRKHFGNSP----KRVSKEY 234
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 166-265 6.49e-03

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 37.32  E-value: 6.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15833711  166 KAQKLIRTQYHRP-LSTALLARELYCNADYLGRVYRRVfHLTLTEAIHRQRV-REAEKLL-ISEARSLTEVAALCGFNDV 242
Cdd:PRK09685 201 KVVALIDQSIQEEiLRPEWIAGELGISVRSLYRLFAEQ-GLVVAQYIRNRRLdRCADDLRpAADDEKITSIAYKWGFSDS 279

                         90       100
                 ....*....|....*....|...
gi 15833711  243 GYFRQIFRKHTGLTPAAWKRRYS 265
Cdd:PRK09685 280 SHFSTAFKQRFGVSPGEYRRKFR 302
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
213-257 6.69e-03

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 37.35  E-value: 6.69e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 15833711  213 RQRVREAEKLLISEARSLTEVAALCGFNDVGYFRQIFRKHTGLTP 257
Cdd:PRK13503 222 RLRLLKARHLLRHSDASVTDIAYRCGFGDSNHFSTLFRREFSWSP 266
COG3837 COG3837
Uncharacterized conserved protein, cupin superfamily [Function unknown];
20-97 9.39e-03

Uncharacterized conserved protein, cupin superfamily [Function unknown];


Pssm-ID: 443048 [Multi-domain]  Cd Length: 115  Bit Score: 35.38  E-value: 9.39e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15833711  20 SRGVGRHSARRLEswEIIFVEKGRLTIQEEERIFLVDAGESLLLWPNRQHVGVEDFPADLKFYWLHFEVKAPDNDPRW 97
Cdd:COG3837  39 ASSSPYHAHSAEE--EFVYVLEGELTLRIGGEEYVLEPGDSVGFPAGVPHRLRNRGDEPARYLVVGTRAPYPDSFDYW 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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