|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
44-442 |
1.55e-107 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 322.60 E-value: 1.55e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 44 MLLLFFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAM 123
Cdd:cd17319 5 IPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTAL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 124 SGMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIG 203
Cdd:cd17319 85 TGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 204 VLGIFLAIGWYMLYRNrehveltaveqaylnagsvnarrdplsfaewrslfrnrtMWGMMLGFSGINYTAWLYLAWLPGY 283
Cdd:cd17319 165 LLGLLLAVLWWFYLRQ---------------------------------------VWGLALGYFGINYALYGLLTWLPTY 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 284 LQTAYNLDLKSTGLMAAIPFLFGAAGMLVNGYVTDWLVKGgmapikSRKICIIAGMFCSAAFTLIVPQATTSMMAVLLIG 363
Cdd:cd17319 206 LKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRG------ARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLS 279
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15834570 364 MALFCIHFAGTSCWGLIHVAVASRMTASVGSIQNFASFICASFAPIITGFIVDTTHSFRLALIICGCVTAAGALAYIFL 442
Cdd:cd17319 280 LAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
33-444 |
2.97e-74 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 237.08 E-value: 2.97e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 33 STRIKRIQTTAMLLLFFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGL 112
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 113 GMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLV 192
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 193 MGWRGMFITIGVLGIFLAIGwymlyrnrehveltaveqaylnagsvnarrdplsfaewrslfrnrTMWGMMLGFSGINYT 272
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALL---------------------------------------------RFWLLALAYFLVYFA 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 273 AWLYLAWLPGYLQTAYNLDLKSTGLMAAIPFLFGAAGMLVNGYVTDWLvkggmapIKSRKICIIAGMFCSAAFTLIVPQA 352
Cdd:COG2271 196 LYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRL-------GRRRKLVLAIGLLLAALALLLLALL 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 353 TTSMMAVLLIGMALFCIHFAGTSCWGLIHVAVASRMTASVGSIQNFASFICASFAPIITGFIVDTTHsFRLALIICGCVT 432
Cdd:COG2271 269 PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALA 347
|
410
....*....|..
gi 15834570 433 AAGALAYIFLVR 444
Cdd:COG2271 348 LLAALLALLLLR 359
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
50-443 |
6.24e-72 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 232.23 E-value: 6.24e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 50 AAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHS 129
Cdd:TIGR00893 2 VTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 130 FTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGVLGIFL 209
Cdd:TIGR00893 82 YVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGIIW 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 210 AIGWYMLYR-NREHVELTAVEQAYLNAGSVNARRD-----PLSFAEWRSLFRNRTMWGMMLGFSGINYTAWLYLAWLPGY 283
Cdd:TIGR00893 162 GVLWLKFIPdPPQKAKWLTEEEKYIVVGGLLAEQQgkgpsTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFFLTWFPTY 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 284 LQTAYNLDLKSTGLMAAIPFLFGAAGMLVNGYVTDWLVKGGMAPIKSRKICIIAGMFCSAAFtLIVPQATTSMMAVLLIG 363
Cdd:TIGR00893 242 LVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLVLSLLM-FATNYVNIPYAALALVA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 364 MALFCiHFAGTSCWGLIHVAVASRMTASVGSIQNFASFICASFAPIITGFIVDTTHSFRLALIICGCVTAAGALAYIFLV 443
Cdd:TIGR00893 321 LGFFG-LGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALALIGALSYLLLV 399
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
38-446 |
2.37e-51 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 178.15 E-value: 2.37e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 38 RIQTTAMLLLFFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFW 117
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 118 SLFQAMSGMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRG 197
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 198 MFITIGVLGIFLAIGWYMLYRNREHVELTAVEQaylnagsvnarrdplSFAEWRSLFRNRTMWGMMLGFSGINYTAWLYL 277
Cdd:COG2223 161 AFLILGILLLVVAVLAWLFLRDPPAGAAAAAKA---------------SLRDQLEALRDPRFWLLSLLYFGTFGSFIGFS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 278 AWLPGYLQTAYNLDLKSTGLMAAIPFLFGAAGMLVNGYVTDWlvkggmapIKSRKICIIAGMFCSAAFTLIVPQATTSMM 357
Cdd:COG2223 226 SWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDR--------IGGRRVLLIVFALMALGLLLLALALGSLWL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 358 AVLLIGMALFCIHFAGTSCWGLIHVAVASRMTASVGSIQNFASFICASFAPIITGFIVDTTHSFRLALIICGCVTAAGAL 437
Cdd:COG2223 298 FLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALV 377
|
....*....
gi 15834570 438 AYIFLVRQP 446
Cdd:COG2223 378 LTLLLYRRP 386
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
48-419 |
1.61e-43 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 157.15 E-value: 1.61e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 48 FFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMV 127
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 128 HSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPI-LAAMMLVMGWRGMFITIGVLG 206
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLvLFGIAELYSWHWVFIVPGIIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 207 IFLAIGWYMLYRN-REHVELTAVEQAYLNAGSVNARRDPLSFAEWRSLFR----NRTMWGMMLGFSGINYTAWLYLAWLP 281
Cdd:TIGR00881 161 IIVSLICFLLLRDsPQSCGLPPAEEMPNEEPDGDAEKKEEELTKKQIFLQyvllNKVLWYISLGYVFVYVVRTGILDWSP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 282 GYLQTAYNLDLKSTGLMAAIPFLFGAAGMLVNGYVTDWLVKGGMAPIksrKICIIAGMFCSAAFTLIVPQATTSMMAVLl 361
Cdd:TIGR00881 241 LYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPL---AVFFMALIIVSLLVYWLNPAANPLMDLIC- 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 15834570 362 iGMALFCIHFAGTSCWGLIHVAVA-SRMTASVGSIQNFASFICASFAPIITGFIVDTTH 419
Cdd:TIGR00881 317 -LFALGFLVYGPQMLIGVIASELApKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
44-441 |
7.30e-43 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 154.63 E-value: 7.30e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 44 MLLLFFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAM 123
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 124 SGMV--HSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFIT 201
Cdd:cd17380 81 TPLLaySSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 202 IGVLGIFLAIGWYMLYrnrehveltaveqaylnagsvnarrdplsfaewrslfrnRTMWGMMLGFSGINYTAWLYLAWLP 281
Cdd:cd17380 161 FGLLGLLWALVWLIYL---------------------------------------PPVWAIIVAHFCMNWGFYILLSWLP 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 282 GYLQTAYnLDLKSTGLMAAIPFLFGAAGMLVNGYVTDWLVKGGMAPIKSRKICIIAGMFCSAAFTLIVPQATTSMMAVLL 361
Cdd:cd17380 202 TYFHEVL-VPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPALFLLLLSHTDSFSLALLC 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 362 IGMALFCIHFAgTSCWGLIHVAVASRMTASVGSIQNFASFICASFAPIITGFIVDTTHSFRLALIICGCVTAAGALAYIF 441
Cdd:cd17380 281 MSVALGLSAFS-SSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEATGSWSLVFVLAAVVNLVGAVVFLL 359
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
46-440 |
2.38e-39 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 146.23 E-value: 2.38e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 46 LLFFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSG 125
Cdd:cd17328 3 VLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 126 MVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAM-MLVMGWRGMFITIGV 204
Cdd:cd17328 83 FAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVaQATGGWRWAFRVTGV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 205 LGIFLAIgwymlyrnreHVELTAVEQAYLNA--GSVNARRDPLSFAEWRSLFRNRTMWGMMLGFSGINYTAWLYLAWLPG 282
Cdd:cd17328 163 LGVLLAI----------LLLLFVREPPRGAAegGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPT 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 283 YLQTAYNLDLKSTGLMA----AIPFLFGAAGMLVNGYVTDWLVKGgmaPIKSRKICIIAGMFCSAAFT-LIVPQATTSMM 357
Cdd:cd17328 233 FFLRAFGVGDLSSADVGlifgAITCIAGVLGVLLGGILADRLRRK---TPRADPLVCAVGLLAAAPFLfLALVLALSNLL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 358 AVLLIgmaLFCIHFAGTSCWGLIHVAVAS----RMTASVGSIQNFASFICASFA-PIITGFIVDTTH-----------SF 421
Cdd:cd17328 310 LAWVL---LFLGEFLLSLNWAPVFAILLYvvipTRRSTASAIQILLSHLLGDAGsPYLIGLISDLLRqnkdsplaeaaSL 386
|
410
....*....|....*....
gi 15834570 422 RLALIICGCVTAAGALAYI 440
Cdd:cd17328 387 QYALLLCSFVLVLGGFFFL 405
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
47-408 |
2.75e-38 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 142.17 E-value: 2.75e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 47 LFFAAVINYLDRSSLSVAN-LTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSG 125
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 126 MVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGVL 205
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 206 GIFLAIGWYMLYRNREHVELTAVEQAYLNAGSVnarrdplsfaeWRSLFRNRTMWgMMLGFSGINYTAWLYLAWLPGYLQ 285
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA-----------WKALLRDPVLW-LLLALLLFGFAFFGLLTYLPLYQE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 286 TaYNLDLKSTGLMAAIPFLFGAAGMLVNGYVTDWLvkggmaPIKSRKICIIAGMFCSAAFTLIVPQATTSMMAVLLIGMA 365
Cdd:pfam07690 229 V-LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRL------GRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLL 301
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 15834570 366 LFCIHFAGTSCWGLIHVAVASRMTASVGSIQNFASFICASFAP 408
Cdd:pfam07690 302 GFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
34-405 |
3.60e-37 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 138.95 E-value: 3.60e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 34 TRIKRIQTTAMLLLFFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLG 113
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 114 MFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVM 193
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 194 GWRGMFITIGVLGIFLAIGWYMLYRNREHveltaveqaylnagsvnaRRDPLSFAEWRSLFRNRTMWGMMLGFSGINYTA 273
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPESRP------------------AARARLRGSLRELLRRPRLLLLLLLAFLLGFGF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 274 WLYLAWLPGYLQTAYNLDLKSTGLMAAIPFLFGAAGMLVNGYVTDWLvkggmapikSRKICIIAGMFCSAAFTLIVPQAT 353
Cdd:COG2814 224 FALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF---------GRRRLLLIGLLLLALGLLLLALAG 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 15834570 354 TSMMAVLLIGMALFCIHFAGTSCWGLIHVAVASRMTASVGSIQNFASFICAS 405
Cdd:COG2814 295 SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
47-440 |
6.52e-35 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 133.71 E-value: 6.52e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 47 LFFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGM 126
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 127 VHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPI--LAAMMLVMGWRGMFITIGV 204
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLggILASSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 205 LGIFLAIGWYMLYRNREHveltaveqayLNAGSVNARRDPLSFAEWRSLFRNRTMWGMMLGFSGINYTAWLYLAWLPGYL 284
Cdd:cd06174 161 LALLAAILLLLVVPDPPE----------SARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 285 QTAYNLDLKSTGLMAAIPFLFGAAGMLVNGYVTDWLvkggmapiKSRKICIIAGMFCSAAFTLIVPQATTSMMAVLLIGM 364
Cdd:cd06174 231 LDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRL--------IGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLL 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15834570 365 ALFCIHFAGTSCWGLIHVAVASRMTASVGSIQNFASFICASFAPIITGFIVDTTHSFRLALIICGCVTAAGALAYI 440
Cdd:cd06174 303 LGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
59-450 |
2.35e-32 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 126.91 E-value: 2.35e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 59 SSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVLVRI 138
Cdd:COG2807 35 TSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTA 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 139 GMGIGEAPMNPCGVKVINDWFNiKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGVLGIFLAIGWYMLYR 218
Cdd:COG2807 115 LIGAGIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLR 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 219 NREHVELTAVEQaylnagsvnarrdplsfAEWRSLFRNRTMWGMMLGFSGINYTAWLYLAWLPGYLQtAYNLDLKSTGLM 298
Cdd:COG2807 194 RRPAAAAAAPAA-----------------ASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILR-DAGLSAATAGLL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 299 AAIPFLFGAAGMLVNGYVTDWLvkGGMAPIksrkICIIAGMFCSAAFTLIVPQATTSMMAVLLIGMALfcihfAGTSCWG 378
Cdd:COG2807 256 LSLFQLAGIPGSLLVPLLADRL--GDRRPL----LLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQ-----GGLFPLA 324
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15834570 379 LIHVAVASRMTASVGSIQNFA---SFICASFAPIITGFIVDTTHSFRLALIICGCVTAAGALAYIFLVRQPINDP 450
Cdd:COG2807 325 LTLIGLRARTPAEAAALSGMAqsvGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLAGRPYVEDA 399
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
68-438 |
3.83e-32 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 125.81 E-value: 3.83e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 68 IREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAPM 147
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 148 NPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGVLGIFLAIGWYMLYRNREhvelta 227
Cdd:cd17475 102 QPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPP------ 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 228 veqaylnAGSVNARRDPLSFAEWRSLFRNRTMWgmMLGFSGINYTA--WLYLAWLPGYLQTAYNLDLKSTGLMAAIPFLF 305
Cdd:cd17475 176 -------AASAATESASTLLRSLKEVLRNRDVW--LIAIAGALLVApqFALLTFLLLFLHDHLGLSVVAAGALLAVAQLG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 306 GAAGMLVNGYVTDWLVKGgmapikSRKICIIAGMFCSAAFTLIVPQATTSMMAVLLigMALFCIHFAGTSCWGLIHVAVA 385
Cdd:cd17475 247 GALGRIGLGRVSDRVFGG------RRRPVLVITAAIAAAALLVLSLLSPGTPLWLL--VLLLILLGLFAIGWNGLYLTLV 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 15834570 386 SRM-----TASVGSIQNFASFICASFAPIITGFIVDTTHSFRLALIICGCVTAAGALA 438
Cdd:cd17475 319 AESagpeqAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALL 376
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
70-443 |
5.66e-31 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 122.68 E-value: 5.66e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 70 EELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAPMNP 149
Cdd:cd17325 24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 150 CGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGVLGiFLAIGWYMLYRNREHveltave 229
Cdd:cd17325 104 AAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA-LLALVLALLLLPEPR------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 230 qaylNAGSVNARRDPLSFAEWRSLFRNRTMWGMMLGFSGINYTAWLYLAWLPGYLQTAYNLDLKSTGLMAAIPFLFGAAG 309
Cdd:cd17325 176 ----PPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 310 MLVNGYVTDWLvkggmapikSRKICIIAGMFCSAAFTLIVPQATTsmMAVLLIGMALFCIhfagtsCWGLIHVAVASRMT 389
Cdd:cd17325 252 QPPAGKLSDRI---------GRKPLILIGLLLSAVALLLLPLATS--FWLLLLLLALLGL------GLGLVFPATLALLA 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15834570 390 ASVG--------SIQNFASFICASFAPIITGFIVDTThSFRLALIICGCVTAAGALAYIFLV 443
Cdd:cd17325 315 DIVPpegrgtamGLFNTAFSLGMVLGPLLGGFLYDAF-GFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
46-442 |
3.91e-30 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 120.37 E-value: 3.91e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 46 LLFFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSG 125
Cdd:cd17474 3 AVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 126 MVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSpPILAAMMLVMGWRGMFITIGVL 205
Cdd:cd17474 83 LSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVG-PLLGGLLAAISWRYPFFLLAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 206 GIFLAIGWYMLYRNREHVEltaveqaylnagsvnARRDPLSFAEWRSLFRNRTMWGMMLGFSGINYTAWLYLAWLPGYLQ 285
Cdd:cd17474 162 IPVAFLAILFLLPEPKEKA---------------KSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLE 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 286 TAYNLDLKSTGLMAAIPFLFGAAGMLVNGYVTdwlvkggmAPIKSRKICIIAGMFCSAAFTLIVPQATTSMMAVLLIGMA 365
Cdd:cd17474 227 LLYGISPIIIGLLFAGWSVLLALGSLFVGRLL--------KKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLF 298
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15834570 366 LFCIHFAGTSCWGLIHVAVASRMTASVGSIQNFASFICASFAPIITGFIVDtTHSFRLALIICGCVTAAGALAYIFL 442
Cdd:cd17474 299 GLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLE-IFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
45-442 |
5.87e-29 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 117.33 E-value: 5.87e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 45 LLLFFAAVINYLDRSSLSVA-----NLTIREELGLSATEI-----------------GALLSVFSLAYGIAQLPCGPLLD 102
Cdd:cd17318 2 ILLFLGFAVVYAMRVNLSVAivamvNSTATHDNNNTSTDKdtlpveapefdwsektqGIILSSFFYGYILTQIPGGYLAE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 103 RKGPRLMLGLGMFFWSLFQAMSGMV--HSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVA 180
Cdd:cd17318 82 KYGAKRVLGYSILITALLTLLTPLAarGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 181 VSPPILAAMMLVMGWRGMFITIGVLGIFLAIGWYMLYRnrehveltaveqaylnagsvnarrdplsfaewrslfrnrTMW 260
Cdd:cd17318 162 IAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLVL---------------------------------------PVW 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 261 GMMLGFSGINYTAWLYLAWLPGYLQTAYNLDLKSTGLMAAIPFLFGAAGMLVNGYVTDWLV-KGGMAPIKSRKICIIAGM 339
Cdd:cd17318 203 AIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRsRGILSTTTVRKLFTSIGF 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 340 FCSAAFTLIVPQAT---TSMMAVLLIGMALFCIHFAGTScwgLIHVAVASRMTASVGSIQNFASFICASFAPIITGFIV- 415
Cdd:cd17318 283 LGPGVFLIALGYLGsnaTLAVVFLTLSVGLSGACYSGFL---VNHLDLAPNYAGTLMGITNTAATIAGIISPLIVGAIVk 359
|
410 420
....*....|....*....|....*....
gi 15834570 416 --DTTHSFRLALIICGCVTAAGALAYIFL 442
Cdd:cd17318 360 ndQTIGQWRIVFFISAAIYILGAIFYLIF 388
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
45-444 |
1.27e-27 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 113.14 E-value: 1.27e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 45 LLLFFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMS 124
Cdd:cd17312 6 LGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFM 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 125 GMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGV 204
Cdd:cd17312 86 GFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 205 LGIFLAIGWYMLYRNREHVELtaveqaylnagsvnarrdPLSFAewrSLFrnrtmwgMMLGFSGINYtawlylaWLPGYL 284
Cdd:cd17312 166 VGLVVAIILFFFLRDSPPYVW------------------VLSLA---YAF-------VYIVRYACLD-------WGPLYL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 285 QTAYNLDLKSTGLMAAIPFLFGAAGMLVNGYVTDWLVKGGMAPIKSrkICIIAGMFCSAAFTLIVPQATTSMMAVLLIGM 364
Cdd:cd17312 211 YEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAV--IYMLLMTLSLALFWFFPHNKLLSIVLLFLIGF 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 365 ALFcihfaGTSC--WGLIHVAVASRMTAS-VGSIQNFASFICASFAPIITGFIVDTTHSFRLALIIcgcvTAAGALAYIF 441
Cdd:cd17312 289 FVG-----GPINliGGAAAQDIGRKEAAGtATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFL----ISAALLSVLL 359
|
...
gi 15834570 442 LVR 444
Cdd:cd17312 360 LLS 362
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
40-416 |
1.12e-25 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 108.10 E-value: 1.12e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 40 QTTAMLLLFFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSL 119
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 120 FQAMSGMVHSFTQFVLVRI----------GMGIGeapmnPCGvKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAM 189
Cdd:cd17345 81 INILIGFVPSATSSVGLMFillflngwfqGMGWP-----PSG-RTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 190 MLVMG---WRGMFITIGVLGIFLA-IGWYMLYRNREHVELTAVEQAYLNAGSVNARRDP---LSFAE--WRSLFRNRTMW 260
Cdd:cd17345 155 LAIFGdgwWRGAFIFPAIIAIIVAvIVLFLGKDTPESEGLPPIEEYKGDYPEEADGEEEeqeLSAWEifVKYVLKNKLLW 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 261 GMMLgfsginYTAWLYLA------WLPGYLQTAYNLDLKSTglMAAIPFLFGAA--GMLVNGYVTDWLVKGGMAPIKSrk 332
Cdd:cd17345 235 YIAI------ANVFVYLVrygildWAPTYLSEVKGFSKAQA--MWAFSLFEWAAipGTLLAGWLSDKLFKGRRAPTGI-- 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 333 ICIIAGMFCsaaftLIVPQATTSMMAVLLIGMALFCIHFAGTSCWGLIHVAVASRMTA--SVGSIQNFASFICASFAPII 410
Cdd:cd17345 305 IFMILVIVA-----LIVYWLAPNVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAgtAAGLTGLFGYLGGSVLATAL 379
|
....*.
gi 15834570 411 TGFIVD 416
Cdd:cd17345 380 IGIIVD 385
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
68-440 |
3.05e-23 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 100.70 E-value: 3.05e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 68 IREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAPM 147
Cdd:cd17324 25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 148 NPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGVLGIFLAIGWYMLyrnrehvelta 227
Cdd:cd17324 105 WAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRL----------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 228 veqayLNAGSVNARRDPLSFAEWRSLFRNRTMWGMM----LGFSGInYTAWLYLAWlpgYLQTAYNLDLKSTGLMAAIPF 303
Cdd:cd17324 174 -----LPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYlitfLLFGGF-FALYTYLAP---FLTDVPGFSSSAIIGLLLLFG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 304 LFGAAGMLVNGYVTDWLVKGGMApiksrkICIIAGMFCSAAFTLIVPQATTSMMAVLLIGMALFCIHFAGTSCwgLIHVA 383
Cdd:cd17324 245 VAGVVGSPLAGRLADRGGRRALL------IALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTR--VLRLA 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 15834570 384 VASRMTASvgSIQNFASFICASFAPIITGFIVDTThSFRLALIICGCVTAAGALAYI 440
Cdd:cd17324 317 PEARGLAS--SLYLAAYNLGGALGAALGGLVLDHG-GWAGVGWVGAALLLLALLLAL 370
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
75-427 |
1.06e-21 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 97.12 E-value: 1.06e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 75 SATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVH--SFTQFVLVRIGMGIGEAPMNPCGV 152
Cdd:TIGR00894 74 SGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAggGIALVVFCRVIQGLAQGSVSPATH 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 153 KVINDWFNIKERGRPMGffnaASTIGVAVSPPILAAMM-----LVMGWRGMFITIGVLGIFLAIGWYMLYRN--REHVEL 225
Cdd:TIGR00894 154 KIIVKWAPPKERSRLLG----MSTSGFQLGTFIFLPISgwlceSWGGWPMIFYVFGIVGCAWSLLWFVFPADdpSIHPCI 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 226 TAVEQAYLNA---GSVNARRDPLSfaeWRSLFRNRTMWGMMLGFSGINYTAWLYLAWLPGYLQTAYNLDLKSTGLMAAIP 302
Cdd:TIGR00894 230 SKFEKKYINSslqGQKGSTRQSLP---IKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLP 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 303 FLFGAAGMLVNGYVTDWLVKGGMAPIK-SRKICIIAGMFCSAAFTLIVPQATT---SMMAVLLIGMALFCIHFAGTScwg 378
Cdd:TIGR00894 307 YLFAWLCSIFAGYLADFLKSSKTLSLTaARKIFNGIGGLGPGIFAYALPYLSAafyLTIIILTLANAVSSGPLAGVL--- 383
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 15834570 379 LIHVAVASRMTASVGSIQNFASFICASFAPIITGFIV--DTTHSFRLALII 427
Cdd:TIGR00894 384 INSLDLAPRFLGFIKGITGLPGFIGGLIASTLAGNILsqDSKNVWLIVFLI 434
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
44-440 |
1.40e-21 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 96.16 E-value: 1.40e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 44 MLLLFFAAVINYLDRSSLSVANLT-IREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQA 122
Cdd:cd17327 7 LPLLCILYFLQYLDKSNISNAAVMgMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 123 MSGMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSpPILAAMMLVM-------GW 195
Cdd:cd17327 87 LTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFG-GLLAYGVFKIlgvgglaGW 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 196 RGMFITIGVLGIFLAIGWYMLYR---------NREHVELTAveqAYLNAGSVNARRDPLSFAEWRSLFRNRTMWGMMLGF 266
Cdd:cd17327 166 RWLFIIEGLITIIIGLVIFFWLPdnpskawflTEEEKELAV---ERLRANQTGKGDQKFKWKQIKEAFKDPRTWLLFLFF 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 267 SGINYTAWLYLAWLPGYLQTAYNLDLKSTgLMAAIPFLFGAAGMLVNGYVTDWlvkggmapIKSRKICIIAGMFCSAAFT 346
Cdd:cd17327 243 FCSQITNNGISNFLPLILKSLGFYSLQTN-LLSVPIGALGAVSLLIAALLSDR--------FKKRGLFAIFACVLALVGS 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 347 LI---VPQATTSMMAVLLIGMAlFCIHFAGTSCWGLIHVAVASRmTASVGSIQNFASFICASFAPIItgFIVDTTHSFRL 423
Cdd:cd17327 314 IIllaAPNPPGAYFAAYILGGG-SYAGFPILLSWISSNCAGYTK-RATVLAIMLIFYNVGNIVAPQI--FRAGDAPRYIP 389
|
410
....*....|....*..
gi 15834570 424 ALIICGCVTAAGALAYI 440
Cdd:cd17327 390 GNIALLVCACVSIVLSV 406
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
31-312 |
9.26e-21 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 92.18 E-value: 9.26e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 31 QRSTRIKRIQTTAMLLLFFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLML 110
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 111 GLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMM 190
Cdd:COG0477 83 LIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 191 LVMGWRGMFITIGVLGIflaIGWYMLYRNREHVELTAVEQAYLNAGSVNARRDPLSFAEWRSLFRNRTMWGMMLGFSGIN 270
Cdd:COG0477 163 AALGWRWIFLINAPLGL---LALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAAL 239
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 15834570 271 YTAWLYLAWLPGYLQTAYNLDLKSTGLMAAIPFLFGAAGMLV 312
Cdd:COG0477 240 LLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLL 281
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
68-440 |
5.82e-20 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 91.08 E-value: 5.82e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 68 IREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAPM 147
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 148 NPCGVKVINDWFNiKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGVLGIFLAIGWYMLYRNREHVELTA 227
Cdd:cd17478 102 HPEGARLASQAAG-GRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 228 VEQaylnagsvnARRDPLSFAEWRSLFRnrtMWGMMLgFSGINYTAwlYLAWLPGYLqTAYNLDLKSTGLMAAIPFLFGA 307
Cdd:cd17478 181 AAK---------SSARSTLKGVWRALLL---LLIIVF-LRSWVLSS--LTTFLPFYL-VQRGYSLVFAGLLLSLFLFAGA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 308 AGMLVNGYVTDwlvKGGmapiksRKICIIAGMFCSAAFTLIVPQaTTSMMAVLLIGMALFCIHFAGTSCWGLIHVAVASR 387
Cdd:cd17478 245 IGTLIGGPLSD---RFG------RRRVIIASLLLAAPFLLLFLL-TPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGN 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 15834570 388 MTASVGSIQNFaSFICASFAPIITGFIVDTThSFRLALIICGCVTAAGALAYI 440
Cdd:cd17478 315 VGLASGLMMGL-SFGLGGIGAPVLGALADAF-GLESVLLILALLPLLGALLAF 365
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
67-440 |
8.84e-20 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 90.71 E-value: 8.84e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 67 TIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAP 146
Cdd:cd17320 24 AIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 147 MNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGVLGIFLAIGwyMLYRNREHvelt 226
Cdd:cd17320 104 GSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLL--VLLFLPET---- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 227 aveqAYLNAGSVNARRdplSFAEWRSLFRNRTMWGMMLGFSGINYTAWLYLAWLPGYLQTAYNLDLKSTGLMaaipFLFG 306
Cdd:cd17320 178 ----LPEEKRKPLLSS---LLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLL----FALN 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 307 AAGMLVNGYVTDWLVKGgmapIKSRKIcIIAGMFCSAAFTLIVPQATTSMMAVLLIGMALFCIHFAGTSCWGLIHVAVA- 385
Cdd:cd17320 247 AIALILGSLLNGRLVRR----FGPRRL-LRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLAl 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 15834570 386 ---SRMTASVGSIQNFASFICASFAPIITGFIVDTTHSFRLALIICGCVTAAGALAYI 440
Cdd:cd17320 322 epfPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
33-446 |
2.66e-19 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 89.14 E-value: 2.66e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 33 STRIKRIQTTAMLLLFFaavINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGL 112
Cdd:COG0738 2 SKKNYRRALIAIYLLFF---LWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 113 GMFFWSLFQAMSGMVHSFTQFVLVR----IGMGIGEAPMNPCGVKVINdwfniKERGRPMGFFNAASTIGVAVSPPILAA 188
Cdd:COG0738 79 GLLLMALGLLLFALAPSYPLLLLALfllgLGLGLLDVAANPYVAALGP-----ETAASRLNLLHAFFSLGALLGPLLGGL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 189 MMLV---MGWRGMFITIGVLGIFLAIGWYMlyrnrehveltaveqAYLNAGSVNARRDPLSFAEWRSLFRNRTMWGMMLG 265
Cdd:COG0738 154 LILLglsLSWHLPYLILAVLLLLLALLFLR---------------SKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLA 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 266 F---SGINYTAWLylaWLPGYLQTAYNLDLKSTGLMAAIPFLFGAAGMLVNGYVTDWLvkggmAPIKSRKICIIAGMFCS 342
Cdd:COG0738 219 IflyVGAEGAIGD---WLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF-----GPVRLLRLSALLAAVGL 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 343 AAFtLIVPQATTSMMAVLLIGMALFCIhfagtscWGLIHVAVASRM---TASVGSIQNFASFICASFAPIITGFIVDTTh 419
Cdd:COG0738 291 LLA-LLAPGPWLALIGLALVGLGLSLM-------FPTIFSLALDGLgkrTAAAVSAVLIMGIVGGAIGPPLIGFLADAF- 361
|
410 420
....*....|....*....|....*..
gi 15834570 420 SFRLALIICGCVTAAGALAYIFLVRQP 446
Cdd:COG0738 362 GLRAAFLVPLVCYLLILLLALALKRKR 388
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
56-442 |
4.95e-19 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 88.38 E-value: 4.95e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 56 LDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVL 135
Cdd:cd17321 10 LDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 136 VRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFIT---IGVLGIFLAig 212
Cdd:cd17321 90 ARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLInvpIGLVALLLA-- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 213 wymlyrnrehveltaveqaylnagsvnarrdplsfaewrslfrnRTMWGMMLGFSGINYTAWLYLAWLPGYLQTAYNLDL 292
Cdd:cd17321 168 --------------------------------------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSP 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 293 KSTGLMaaipFLFGAAGMLVNGYVTDWLVKggmaPIKSRKICIIAGMFCSAAFTLIVPQATTSMMAVLLIGMALFCIHFA 372
Cdd:cd17321 204 LQAGLA----LLPLALAMLVAAPLAGRLAD----RFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLG 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 373 G--TSCWGLIHVAVASRMTASVGSIQNFASFICASFAPIITGFIVDT----------------------THSFRLALIIC 428
Cdd:cd17321 276 LfaTPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAglsanlgdsgvaallsaaaaafAAGFHLAFLVA 355
|
410
....*....|....
gi 15834570 429 GCVTAAGALAYIFL 442
Cdd:cd17321 356 AALALLAALLALLL 369
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
45-440 |
2.55e-18 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 86.17 E-value: 2.55e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 45 LLLFFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMS 124
Cdd:cd17355 6 AVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 125 GMVHSFTQFVLVRIGMGIGEAPMNPCGV-KVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIG 203
Cdd:cd17355 86 ALATSLWQLYLLWGLLGGGGAGTLAAVAfATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 204 -VLGIFLAIGWYMLYRNREHVELTAVEQAylnagsvnarRDPLSFAEWRSLFRNRTMWGMMLGFSGINYTAWLYLAWLPG 282
Cdd:cd17355 166 lLALLVLVPVLLLLRRRPADLALRAYDDA----------SPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVP 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 283 YLQTAYnLDLKSTGLMAAIPFLFGAAGMLVNGYVTDwlvkggmaPIKSRKICIIAgMFCSAAFTLIVPQATTSMMAVLLI 362
Cdd:cd17355 236 YLADRG-ISPAAAAVALALIGLFNIVGRLLSGWLGD--------RYSPRRLLAAS-YALRALGLALLLLLPFPPLALLLF 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 363 GMALFCIHFA-GTSCWGLIHVAVASRMTASVGSIQNFASFICASFAPIITGFIVDTTHSFRLALIICG--CVTAAGALAY 439
Cdd:cd17355 306 AALFGLGWGAtVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAValGLIAALLVLP 385
|
.
gi 15834570 440 I 440
Cdd:cd17355 386 I 386
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
44-438 |
7.27e-18 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 84.58 E-value: 7.27e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 44 MLLLFFAAVINYLDRSSLSVANLTIREE--LGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQ 121
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 122 AMSGMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGV----AVSPPILAAMMLVMGWRG 197
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGAllaaLVASLLIPLLSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 198 MFITIGVLGIflaIGWYMLYRnrehveltaveqaylnagsvnarrdplsfaewrslfrnrtMWGMMLGFSGINYTAWLYL 277
Cdd:cd17316 161 LFLIGALPAL---LALLLRRR----------------------------------------TLLLILLWFFISFGYYGLT 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 278 AWLPGYLQTAYNLDLKSTGLMAAIPFLFGAAGMLVNGYVTDWLvkggmapikSRKICIIAGMFCSAAFTLIVPQATTSMM 357
Cdd:cd17316 198 TFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI---------GRKKTLVIGLILSGILALPLFYLLSGSP 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 358 AVLLIGmaLFCIHFAGTSCWGLIHVAVA----SRMTASVGSIQNFASFICASFAPIITGFIVDTTHSFRLALIICGCVTA 433
Cdd:cd17316 269 TLLLLL--LFILSFFVGGVWGALYAYLAelfpTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAI 346
|
....*
gi 15834570 434 AGALA 438
Cdd:cd17316 347 VALIV 351
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
16-217 |
8.09e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 81.85 E-value: 8.09e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 16 PSSSADIPVPPDGLVQRSTRIKRIQTTAMLLLFFAAVINYLDRSSLSVA-NLTIREELGLSATEIGALLSVFSLAYGIAQ 94
Cdd:cd17325 173 EPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFlPLYAAELGGLSPAQIGLLFGAQGLASALSQ 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 95 LPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAA 174
Cdd:cd17325 253 PPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTA 332
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 15834570 175 STIGVAVSPPILAAMMLVMGWRGMFITIGVLGIFLAIGWYMLY 217
Cdd:cd17325 333 FSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
44-433 |
3.08e-16 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 79.76 E-value: 3.08e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 44 MLLLFFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAM 123
Cdd:cd17488 5 LASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINIL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 124 SGMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIG 203
Cdd:cd17488 85 FGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGMYVPG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 204 VLGIFLAIgwymlyrnrehveltaveqaylnagsvnarrdplsFAEWRSLFRNRTMWGMMLGFSGINYTAWLYLAWLPGY 283
Cdd:cd17488 165 IIAILMGI-----------------------------------VLCWRLRDRPPYIWLLAFCYVLVYVVRTAINDWGNLY 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 284 LQTAYNLDLKSTGLMAAIPFLFGAAGMLVNGYVTDWLVKGGMAPIksrKICIIAGMFCSAAFTLIVPQATTSMMAVLL-- 361
Cdd:cd17488 210 LSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLFKGNRGPM---NLIFALGLLVSVGALWLVPVHSYWLLATCFft 286
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15834570 362 IGMALFCIH-FAGTSCWGLIHVAVASRMTASVGsiqnFASFICASFAPIITGFIVDTTH--SFRLALIICGCVTA 433
Cdd:cd17488 287 IGFFVFGPQmLIGMAAAECSHKDAAGSATGFVG----LFAYLGAALAGYPLAKVIESWGwsGFFIVISIAAAISG 357
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
48-442 |
2.52e-15 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 77.34 E-value: 2.52e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 48 FFAAVINY-LDRSSLSVANLTIRE---ELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAM 123
Cdd:cd17371 1 FWAAFLGWaLDGFDLLLLGLVLPAliaEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 124 SGMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIG----VAVSPPILAAMMLVMGWRGMF 199
Cdd:cd17371 81 CGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGwllaTLLAALLFPLLPPEIAWRVLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 200 ItIGVLGIFLAigWYMlyrnREHVELTAVEQAYLNAGSVNARRDPLSFAEWRSLFRNRTMWGMMlgFSGINYTAWLYLAW 279
Cdd:cd17371 161 L-LGALPALLV--LFI----RRFVKEPPQWQAARAARRHFADRPSLRELFSPPLLRTTLLASLL--ATGALGGYYGITTW 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 280 LPGYLQTAYNLDLKSTGLMAAIPFLFGAAGMLVNGYVTDWLvkggmapikSRKICIIAGMFCSAAFTLIVPQATTSMMAV 359
Cdd:cd17371 232 LPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRI---------GRRNNFALFALGSAISILLYFFLPLSPTLI 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 360 LLIGMALFCIHFAGTSCWG--LIHVAVASRMTASVGSIQNFASFICASFaPIITGFIVDTThSFRLALIICGCVTAAGAL 437
Cdd:cd17371 303 LILGFPLGFFASGPFSGMGayLTELFPTAVRATAQGFCYNVGRIIGALF-PFLVGFLATSG-SLGTAIAVFAAVYYIAGL 380
|
....*
gi 15834570 438 AYIFL 442
Cdd:cd17371 381 VLALL 385
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
30-365 |
4.00e-15 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 77.06 E-value: 4.00e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 30 VQRSTRIKRIQTtaMLLLFFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLM 109
Cdd:PRK11663 13 IDARYRYWRRHI--LITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYF 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 110 LGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAM 189
Cdd:PRK11663 91 MGIGLIATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 190 MLVMGWRGMFITIGVLGIFlaIGWYMLYRNRE-----------HVELTAVEQAYLNAGSVNARRDPLSfaewRSLFRNRT 258
Cdd:PRK11663 171 ALHYGWRYGMMIAGIIAIV--VGLFLCWRLRDkpqamglpsvgEWRHDALELAQQQEGAGLSRKEILT----KYVLLNPY 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 259 MWgmMLGFS---------GINytawlylAWLPGYLQTAYNLDLKSTGLMAAIPFLFGAAGMLVNGYVTDWLVKGGMAPIk 329
Cdd:PRK11663 245 IW--LLSFSyvlvyvvraAIN-------DWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKLFNGNRGPM- 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 15834570 330 srKICIIAGMFCSAAFTLIVPQATTSMMAV-------------LLIGMA 365
Cdd:PRK11663 315 --NLIFAAGILLSVGSLWLMPFASYVMQAAcfftigffvfgpqMLIGMA 361
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
72-442 |
8.95e-15 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 75.69 E-value: 8.95e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 72 LGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAPMNPCG 151
Cdd:cd17473 30 VPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 152 VKVINDWFNIKERGRPMGFFNAASTIGVAVSpPILAAMMLVMGWRGMFITIGVLGIFLAIGWYMLYRNREHVELTAVEQA 231
Cdd:cd17473 110 TALIGDYFEGEERAKMLGLQSAAMSLGGVVF-LLLGGALAEIGWRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPGA 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 232 YLNAGSVNARRDPLSFAewrslfrnrTMWGMMLGFSGINYtawlylawLPGYLQTAYNLDLKSTGLMAAIPFLFGAAGml 311
Cdd:cd17473 189 ATAAALPWKRVLPIYFL---------AFLAMLLFYVIPIQ--------LPFLLQERGGGSAALIGLALAIASLAGAIG-- 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 312 vnGYVTDWLVKggmaPIKSRKICIIAGMFCSAAFTLIvpqATTSMMAVLLIGMALFCIHFagtscwGLIHVAVASRMTAS 391
Cdd:cd17473 250 --ALLFGRLKR----RLGKRRLLAIGFALMALGFLLL---ALASGLWVVLLGAILAGLGF------GLLLPTLNSWAMSL 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 15834570 392 VG--------SIQNFASFICASFAPIITGFIVDTTHSFRLALIICGCVTAAGALAYIFL 442
Cdd:cd17473 315 VPpelrgramGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
40-444 |
1.19e-14 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 75.45 E-value: 1.19e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 40 QTTAMLLLFFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSL 119
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 120 FQAMSGMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMF 199
Cdd:cd17343 81 TTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 200 ITIGVLGIFLAIGWYMLYRNR-EHVELTAVEQAYLNAGSvnaRRDPLSFAEWRSLFRNRTMWGMMLGFSGINYTAWLYLA 278
Cdd:cd17343 161 SISGTVAVVMSVVCLLFIKNEpSDVGLNNIEEEESKGKK---KKSPRGESTLKELLLSPFLWLLSLGYLVVFGVKTAVTD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 279 WLPGYL-QTAYNLDLKSTGLMAAIPfLFGAAGMLVNGYVTDWLVK--GGMAPIKSRK---ICIIAGMFCSAAFTLIVPQA 352
Cdd:cd17343 238 WGQLFLiQDKGQSALTGSSFMSSLE-VGGFVGSIAAGYLSDWAVAkhGSSSRGNPRMplaLVFMAGLTVSLHLFRVHITS 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 353 TTSMMAVLLIGMALfcihfaGTSCWGLIHVAVASRMTASVGSIQNFASFICASFA---PIITGF---IVDTTHSFRLALI 426
Cdd:cd17343 317 DSSELFILLLGFLI------GFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAAnvgGVLAGLpfsYIAKHYDWRTAFL 390
|
410
....*....|....*...
gi 15834570 427 ICGCvTAAGALAYIFLVR 444
Cdd:cd17343 391 LLEI-LCAITVVILFLLR 407
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
45-438 |
5.71e-14 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 73.05 E-value: 5.71e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 45 LLLFFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMS 124
Cdd:cd17341 2 HLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 125 GM-VHSFTQFVLVRIGMGIGEApMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVS----PPILAAMMLV---MGWR 196
Cdd:cd17341 82 ALaVSSYWGLLVLGFLLGFAGA-NFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSqllaPLIAGAIVFDggfVGWR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 197 GMFITIGVLGIFLAIGWYMLYRNREHVeltaveqaylnagsvnARRDPLSFAEWRSLFRNRTMWGMMLGFsGINYTAWL- 275
Cdd:cd17341 161 NAFFVPGILLAIAAVLVLLFGDDLPTG----------------KASALEFLKVQLAVLKNYRTWILSLLY-GVTFGSFVg 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 276 YLAWLPGYLQTAYNLDLKSTGLMAaipFLFGAAGMLVN---GYVTDwlVKGGmapikSRKICIIAGMFCSAAFTLIVPQA 352
Cdd:cd17341 224 FSNVLPTYFKTRFGLPLVTAGILA---ALFPLAGALARpagGWLSD--RFGG-----RRRLWWLFIVMTIGAALLSLSLP 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 353 TTSMMAVLLIGMALFCIHFAGTSC------WGLIHVAVASRMTASVGSIQNFASFicasFAPIITGFIVDTTHSFRLALI 426
Cdd:cd17341 294 TSGTNLVLFLALFVALGLGAGAGNgsvfrmVPFIFRRELGAVTGLVGAIGGLGGF----FLPLLFGSSALMTGSGVGAFS 369
|
410
....*....|..
gi 15834570 427 ICGCVTAAGALA 438
Cdd:cd17341 370 LFGVLAVACTLL 381
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
71-451 |
1.71e-13 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 71.86 E-value: 1.71e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 71 ELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRL----------MLGLGMFFWSLFQAMS-GMVHSFTQFVLVRIG 139
Cdd:COG2211 40 VLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpwiligAIPLALSFVLLFTAPDlSPTGKLIYALVTYLL 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 140 MGIGEAPMNPCGVKVINDWF-NIKERGRPMGFFNAASTIG---VAVSPPILAAMMLVMGWRGMFITIGVLGIFLAIGWYM 215
Cdd:COG2211 120 LGLAYTLVNIPYSALGAELTpDYEERTRLSSWRFAFAGLGgllASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLL 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 216 LYRN-REHVEltaveqaylnagsvnARRDPLSFAE-WRSLFRNRTMWGMMLGFSGINYTAWLYLAWLPGYLQTAYNLDLK 293
Cdd:COG2211 200 TFFGtKERPV---------------PEEEKVSLKEsLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAA 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 294 STGLMAAIPFLFGAAGMLVNGYVTDWLvkggmapikSRKICIIAGMFCSAAFTLIVPQATTSMMAVLLIGMALFCIHFAG 373
Cdd:COG2211 265 LVGLLLALYFLAALLGAPLWPRLAKRF---------GKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGA 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 374 TscWGLIHVAVA-----------SRMTASVGSIQNFASFICASFAPIITGFIVD-------------TTHSFRLALIICG 429
Cdd:COG2211 336 I--LVLPWAMLAdvvdydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLLAlfgyvagaaqspsALTGIRLLFFLLP 413
|
410 420
....*....|....*....|..
gi 15834570 430 CVTAagALAYIFLVRQPINDPR 451
Cdd:COG2211 414 AVLL--LLAALLLLFYPLTRER 433
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
80-440 |
2.53e-13 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 71.35 E-value: 2.53e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 80 GALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQ--FVLVRIGMGIGEAPMNPCGVKVIND 157
Cdd:cd17381 68 GWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAgyLIAVRALEGLGEGVTFPAMHAMWAS 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 158 WFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGVLGIFLAIGWYMLYRnrehveltaveqaylnags 237
Cdd:cd17381 148 WAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLVM------------------- 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 238 vnarrdPLsfaewrslfrnrtmWGMMLGFSGINYTAWLYLAWLPGYLQTAYNLDLKSTGLMAAIPFLFGAAGMLVNGYVT 317
Cdd:cd17381 209 ------PL--------------WAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIA 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 318 DWLV-KGGMAPIKSRKICIIAGMFCSAAFTLIVPQATTS---MMAVLLIGMALFCIHFAGtscWGLIHVAVASRMTASVG 393
Cdd:cd17381 269 DNLReKQNFSTVCVRKIFTLIGMIGPAVFLLAAGFTGCNyslAVAFLTISSTLGGFSASG---FNINHLDIAPSYAGILL 345
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 15834570 394 SIQNFASFICASFAPIITGFIV--DTTHSFRLALIICGCVTAAGALAYI 440
Cdd:cd17381 346 GITNTFATIPGMVGPVIAKSLThnNTVEEWQTVFYISAAINVFGAIFFT 394
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
71-443 |
9.86e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 69.16 E-value: 9.86e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 71 ELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAPMNPC 150
Cdd:cd17489 25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 151 GVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGVLgifLAIGWYMLYRNREHveltaveq 230
Cdd:cd17489 105 AATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVL---ALLALLLVFLVKDP-------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 231 aylnaGSVNARRDPLSFAEWRSLFRNR-TMWGMMLGFSGINYTAwlylawlpgyLQTAYNLDLKSTGL-MAAIPFLFGAA 308
Cdd:cd17489 174 -----PPVAAEEAEAGTRAFRRLVEKKvLPPALILFLASIAYGA----------ISTFLPLYAAERGIsNAGLFFTVYAI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 309 GMLVNGYVTdwlvkGGMAPIKSRKICIIAGMFCSAAFTLIVPQATTSMMavLLIGMALFCIHF-AGTSCWGLIHVAVASR 387
Cdd:cd17489 239 ALLLSRPFS-----GKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWM--LLLAAVLYGLGFgLLFPALQALAVDLVPP 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 15834570 388 MTASVGSIQNFASF-ICASFAPIITGFIVDTThSFRLALIICGCVTAAGALAYIFLV 443
Cdd:cd17489 312 HRRGAANGTFFIFFdLGIGLGGLLLGLVAELF-GYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
44-443 |
9.14e-12 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 66.45 E-value: 9.14e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 44 MLLLFFAAVinyLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAM 123
Cdd:cd17503 1 LLLGAFMAI---LDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 124 SGMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMF---I 200
Cdd:cd17503 78 CGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFyinL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 201 TIGVLGIFLAigwymlyrnrehveltaveqAYLNAGsvnarrdplsfaewrsLFRNRT-------MWGMMLGFSGINYTa 273
Cdd:cd17503 158 PIGILALLLA--------------------PLLDLR----------------LFKDRNftlglllSFLLGLGLFGAMFL- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 274 wlylawLPGYLQTAYNLDLKSTGLMAAIPFLFGAAGMLVNGYVTDWLvkgGMAPIksrkicIIAGMFCSAAFTLIVPQAT 353
Cdd:cd17503 201 ------LPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKF---GPRLL------LLAGLLLLALGTLLLAFLT 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 354 TSM--------MAVLLIGMALFcihFAGTSCWGLIHVAV--ASRMTASVGSIQNFA-SFICASFAPIITGFIvdTTHSFR 422
Cdd:cd17503 266 PDTslwliilpLFIRGLGMGLV---FMPLNTLALNSLPPeqIGDATALFNTIRQLGgSIGTALLATLLTNRT--QFHHSR 340
|
410 420
....*....|....*....|....
gi 15834570 423 LALIICGCVTAAG---ALAYIFLV 443
Cdd:cd17503 341 LSELLAQQVQKQAliiAFNDAFLV 364
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
70-442 |
1.13e-11 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 66.04 E-value: 1.13e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 70 EELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVL-VRIGMGIGEAPMN 148
Cdd:cd17352 31 EEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLtYGVLGGLGLGLIY 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 149 PCGVKVINDWFNiKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGVLGIFLAIGWYMLyrnrehveltav 228
Cdd:cd17352 111 SPAIVIVGQYFE-KKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLLL------------ 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 229 eqaylnagsvnarrdplsfaewrSLFRNRTMWGMMLGFSGINYTAWLYLAWLPGYLQTAYNLDLKSTGLMAAIPFlFGAA 308
Cdd:cd17352 178 -----------------------RLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGI-SDIV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 309 GMLVNGYVTDWlvkggmaPIKSRKICIIAGMFCSAAFTLIVPQATTsmmavlLIGMALFCIHFA-GTSCWGLIHVAVAS- 386
Cdd:cd17352 234 GRILLGLLADK-------PRIGRLYLYIFTLLILGLSLLAFPLATT------YVGLIVFSVLFGfCSGSYSSLTPVILAd 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15834570 387 -----RMTASVGsIQNFASFICASFAPIITGFIVDTTHSFRLALIICGCVTAAGALAYIFL 442
Cdd:cd17352 301 lvgleKLSNAYG-LVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLL 360
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
62-442 |
3.32e-11 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 64.55 E-value: 3.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 62 SVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVLVR-IGM 140
Cdd:cd17353 23 SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYgVLG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 141 GIGEAPMNPCGVKVINDWFNIKeRGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGVL-GIFLAIGWYMLyrn 219
Cdd:cd17353 103 GIGAGIGYITPVSTAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIfLIIIVIGAFLI--- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 220 REHVELTAVEQAYLNAgsvNARRDPLSFAEWRSLFRNRTMWGMMLGFSgINYTAWLYL-AWLPGYLQTAYNLDLKSTGLM 298
Cdd:cd17353 179 RDPPKGWVPPGVDPLA---NNAENSPRDYTPREMLRTPTFWLLWLMFF-LNATAGLMLiGQAKPIGQEFAGLDAGIAALA 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 299 AAIPFLFGAAGMLVNGYVTDWLvkggmapikSRKICIIAGMFCSAAFTLIVPqaTTSMMAVLLIGMAlFCIHFAGTSCWG 378
Cdd:cd17353 255 VSILSIFNGGGRPFWGWLSDKI---------GRKNTLSIAFLIQGVAMFLLP--FIGSVAVLFVLGV-ALIGFCYGGGFA 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15834570 379 LIHVAVASRM-TASVGsiQNFASFICA-SFAPIITGFI---VDTTHSFRLALIICGCVTAAGALAYIFL 442
Cdd:cd17353 323 LFPALTADFFgTKNAG--TNYGLLYTAkGVGGLIGPIIaayVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
79-447 |
1.94e-10 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 62.33 E-value: 1.94e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 79 IGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGM-----VHSFTQFVLVRIGMGIGEAPMNPCGVK 153
Cdd:cd17344 64 LGALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLgyywnIHSLWYFVVVQILAGLFQSTGWPSVVA 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 154 VINDWFNIKERGRPMGFFNAASTIGvAVSPPILAAMMLVMGWRGMFITIGVLGIFLAIGWYMLYrnrehveltaVEQayl 233
Cdd:cd17344 144 CVGNWFGKGKRGLIMGIWNSHTSVG-NILGSLIAGIFVSSAWGLSFIVPGIIIAAMGVLVFLFL----------VEH--- 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 234 NAGSVnarrdPLSFAewrslfrnrtmwgmmLGFSG-INYTawlYLAWLPGYLQTAYNLDLKSTGLMAAIPFLFGAAGMLV 312
Cdd:cd17344 210 PPGVI-----EFSLC---------------LFFAKlVSYT---FLYWLPLYISNTAILSAKKAGDLSTLFDVGGIVGGIL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 313 NGYVTDWLvkgGMAPIKSrkiciiAGMFCSAAFTLIVPQATTSMMAVLLIGMALFCIHFAGTScWGLIHVAVA------- 385
Cdd:cd17344 267 AGYISDYT---GGRATTC------AAMLILAAPMLFIYNYFGQVSMTTNIVLLIVCGLLVNGP-YALITTAVSadlgthk 336
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15834570 386 -----SRMTASVGSIQNFASFICASFAPIITGFIVDTTHSFRLALIIcgcvtAAGALAYIFLVRQPI 447
Cdd:cd17344 337 slkgnARALATVTAIIDGTGSIGAALGPLLAGLISSRGWNNVFYMLI-----AADVCAGLLLTRLVY 398
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
43-438 |
2.95e-10 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 61.99 E-value: 2.95e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 43 AMLLLFFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPR----LMLGLG---MF 115
Cdd:PRK09556 30 SYLVVFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKqflpFLLILSaicML 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 116 FWSLfqAMSGMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAvsppiLAAMMLVMGW 195
Cdd:PRK09556 110 GFGA--SLGSGSVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGA-----GAGGVALWGA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 196 R--------GMFITIGVLGIFLAIgWYMLYRNREHVEL--TAVEQAY---LNAGSVNARRDPLSFAE--WRSLFRNRTMW 260
Cdd:PRK09556 183 NyffdghviGMFIFPSIIALIIGF-IGLRYGSDSPEELgwGKAEEIFgepISEEDKETESTDMTKWQifVEYVLKNPVIW 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 261 gmMLGFSGInytaWLYLA------WLPGYLQTAYNLDlKSTGLMAAIPFLFGA-AGMLVNGYVTDwLVKGgmapikSRKI 333
Cdd:PRK09556 262 --LLCFANI----FLYIVrigidnWSPVYAFQELGFS-KEDAINTFTLFEIGAlVGSLLWGWLSD-LANG------RRAL 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 334 CIIAGMFCsAAFTLIVPQATTSMMAVLLigmALFCIHFAGTSCWGLIHVAV---ASRMTASV--GSIQNFASFICASFAP 408
Cdd:PRK09556 328 VACIALAL-IIFTLGVYQHATSEYMYLA---SLFALGFLVFGPQLLIGVAAvgfVPKKAIGVanGIKGTFAYLFGDSFAK 403
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 15834570 409 IITGFIVDTTHS------------------FRLALIICGCVTAAGALA 438
Cdd:PRK09556 404 VGLGMIADPTKNgtpifgytltgwagtfaaLDIAAIGCICLMAIVAVM 451
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
29-216 |
3.81e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 61.48 E-value: 3.81e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 29 LVQRSTRIKRIQTTAMLLLFFAAVINyldrsslSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRL 108
Cdd:cd06173 203 YLRRSPLLRLLLLALALFALLGGALT-------VLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGR 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 109 MLGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAA 188
Cdd:cd06173 276 LLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGL 355
|
170 180
....*....|....*....|....*...
gi 15834570 189 MMLVMGWRGMFITIGVLGIFLAIGWYML 216
Cdd:cd06173 356 LADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
70-441 |
4.18e-10 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 61.09 E-value: 4.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 70 EELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAPMNP 149
Cdd:cd17329 28 QQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEP 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 150 CGVKVINDwfNIKERGRPMGF--FNAASTIGVAVSpPILAAMMLVMGWRGMFITIGVLGIFLAIGWYMLYRNREHVELTA 227
Cdd:cd17329 108 ASEAMIAD--VTTPENRTRAFslLYWAINLGVAIG-PLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 228 VEQAylnagsvnarrdplSFAEWRSLFRNRTMWGMMLGFSGINYT-AWLYLAwLPGYLQTAYNLDLKSTGLMAAIPFLFG 306
Cdd:cd17329 185 EKTE--------------ILRGYKIVLRDRAFLLFLLASFLISLIyFQLEST-LPVYVVEILGLGESLLGLLLALNALLI 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 307 AAGMLvngyvtdwLVKGGMAPIKSRKIcIIAGMFCSAAFTLIVPQATTsmMAVLLIGMALFCIhfAGTSCWGLIHVAVAS 386
Cdd:cd17329 250 VLLQF--------PVARLVERFRLRKI-LMIGILLFAIGFAVLAFANT--LAVLILAMIVLTL--GEMLVFPAVQTLVAA 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 15834570 387 RM-TASVGSIQNFASF---ICASFAPIITGFIVDTTHSFRLALIICGCVTAAGALAYIF 441
Cdd:cd17329 317 LApPDKRGSYMGFYALawgLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
37-327 |
7.64e-10 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 60.49 E-value: 7.64e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 37 KRIQTTAMLLLFFAAVINYLDRSSLSVANLTIREElGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFF 116
Cdd:PRK11273 24 RRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLIL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 117 WSLFQAMSGMVHSFTQ-----FVLVRI-----GMGigeapMNPCGVKVINdWFNIKERGRPMGFFNAASTIGVAVSPPI- 185
Cdd:PRK11273 103 AAAVMLFMGFVPWATSsiavmFVLLFLcgwfqGMG-----WPPCGRTMVH-WWSQKERGGIVSVWNCAHNVGGGLPPLLf 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 186 LAAMMLVMGWRGMFITIGVLGIFLAIGWYMLYRNR-EHVELTAVEQaYLN---AGSVNARRDPLSFAE--WRSLFRNRTM 259
Cdd:PRK11273 177 LLGMAWFNDWHAALYMPAFAAILVALFAFAMMRDTpQSCGLPPIEE-YKNdypDDYNEKHEQELTAKQifMQYVLPNKLL 255
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15834570 260 WGMMLGFSGINYTAWLYLAWLPGYLQTA--YNLDLKSTGLmaaipFLF---GAAGMLVNGYVTDWLVKGGMAP 327
Cdd:PRK11273 256 WYIAIANVFVYLLRYGILDWSPTYLKEVkhFALDKSSWAY-----FLYeyaGIPGTLLCGWMSDKVFRGNRGA 323
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
45-442 |
1.04e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 59.94 E-value: 1.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 45 LLLFFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPR-----LMLGLGMFFWSL 119
Cdd:cd06173 2 RLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRrllilADLLRALLAAVL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 120 FQAMSGMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMF 199
Cdd:cd06173 82 ALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 200 ItIGVLGIFLAIGWYMLYRNREHVeltaveqaylNAGSVNARRDPLSFAEWRSLFRNRTMWGMMLGFSGINYTAWLYLAW 279
Cdd:cd06173 162 A-INALSFLLSALLLLFIRRPPPA----------APGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 280 LPGYLQTAYNLDLKSTGLMAAIpflfGAAGMLVNGYVTDWLVKggmapIKSRKICIIAGMFCSAAFTLIVPQATTSMMAV 359
Cdd:cd06173 231 LPLLAKEVLGGGAAGYGLLLAA----FGVGALLGALLLGRLSK-----RRRRGRLLLIGALLLGLALLVLGLSPSLWLLL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 360 LLIGMALFCIHFAGTSCWGLIHVAVASRMTASVGSIQNFASFICASFAPIITGFIVDtTHSFRLALIICGCVTAAGALAY 439
Cdd:cd06173 302 AALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLAD-ALGLSAVFLLAGALLLLAALLL 380
|
...
gi 15834570 440 IFL 442
Cdd:cd06173 381 LLL 383
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
45-446 |
1.45e-09 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 59.52 E-value: 1.45e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 45 LLLFFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMS 124
Cdd:cd17365 2 ALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 125 GMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGV 204
Cdd:cd17365 82 AFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 205 LGIFLAIgwymlyrnrehveltaveqayLNAGSVNArrdplsfaeWRSLFRNrtmwgmMLGFSGINytawlylAWLPGYL 284
Cdd:cd17365 162 PPLILLP---------------------LLRGTLLL---------WVTFFMG------LLLVYLLN-------SWLPKLM 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 285 QTAyNLDLKSTGLMAAIPFLFGAAGMLVNGYVTDWLvkggmapikSRKICIIAGMFCSAAFTLIVPQATTSmmaVLLIGM 364
Cdd:cd17365 199 VEA-GYSLSQALTITLLLNIGGVIGSLLLGWLADRF---------GPKRVLALFFALGAVSLALLGVSPAS---LVLLYV 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 365 ALFCIHFAGTSCWGLIHVAVA----SRMTASVGSIQNFASFICASFAPIITGFIVDTTHSFRLALIICGCVTAAGALAYI 440
Cdd:cd17365 266 LVFLAGACVNGAQVGLYALAArfypTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGALAVL 345
|
....*.
gi 15834570 441 FLVRQP 446
Cdd:cd17365 346 LLRLRR 351
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
62-367 |
2.41e-09 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 58.85 E-value: 2.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 62 SVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMV-HSFTQFVLVRIGM 140
Cdd:TIGR00886 22 PLAVFLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAvQSYSVLLLIRLFI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 141 GIGEAPMNPCgVKVINDWFNIKERGRPMGFFNAASTIGVAVsppilaaMMLVMGW-RGMFITIGVLGIFLAIGWYMLYRN 219
Cdd:TIGR00886 102 GIAGGSFASC-MPWISFFFPKKIQGTALGLAAGWGNMGGGV-------AQFVMPPiIGSLIFGGGQPAHLAWGWAFVIVP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 220 REHVELTAVeqAYLNAGSVNARRDP----LSFAEWRSLFRNRTMWGMML-------GFSGINytawlylAWLPGYLQTAY 288
Cdd:TIGR00886 174 AGILLLPAL--LIFFVGADTPPGKPatgkLSFKEALKVFGNRHTWILALlysvtfgSFLGVS-------SIFAMLFKDQF 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 289 NLDLKSTGlmaAIPFLFGAAGMLVN---GYVTDWLvkgGMAPIKSRKICIIAGmfCSAAFTLIVPQATTSMMAVLLIgMA 365
Cdd:TIGR00886 245 GLSKVQAG---AYASLGGFLGSLARpagGAISDRL---GGARKLLMNFLGVAM--GAFLVVLGLVSDGSLAAFIVLF-VA 315
|
..
gi 15834570 366 LF 367
Cdd:TIGR00886 316 LF 317
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
64-267 |
3.11e-09 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 58.39 E-value: 3.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 64 ANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIG 143
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 144 EApmnpCGVKVIN----DWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGVLGIFLAIGWYMLYRN 219
Cdd:PRK11102 93 AA----AASVVINalmrDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPE 168
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 15834570 220 REHVEltaveqaylnagsvnaRRDPLSF----AEWRSLFRNRTMWGMML--GFS 267
Cdd:PRK11102 169 TLPKE----------------RRQPFHLrttiRNFASLFRHKRVLGYMLasGFS 206
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
30-210 |
4.69e-09 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 58.14 E-value: 4.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 30 VQRSTRIKRIQTTAMLLLFFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLM 109
Cdd:TIGR00895 5 NIRKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 110 LGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAM 189
Cdd:TIGR00895 85 LLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWL 164
|
170 180
....*....|....*....|.
gi 15834570 190 MLVMGWRGMFITIGVLGIFLA 210
Cdd:TIGR00895 165 IPVFGWRSLFYVGGIAPLLLL 185
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
47-442 |
8.35e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 57.20 E-value: 8.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 47 LFFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGM 126
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 127 VHSFTQFVLVRIGMGIGeAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGVLG 206
Cdd:cd17504 81 APNLPVLIAGRALQGIG-GAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 207 IFLAIgwymlyrnrehveltaveqaylnagsvnarrdpLSFAEWRSLFRNRTMWGMMLGFSGINYTAWLYLAWLPGYLQT 286
Cdd:cd17504 160 VLLAA---------------------------------LVPLIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQL 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 287 AYNLDLKSTGLMAAIPFLFGAAGMLVNGYVTDWLvkggMAPIKSRKICIIAGMFCSAAFTLIVPQATTSMMAVLLIGMAL 366
Cdd:cd17504 207 PTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRL----IARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIG 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 367 FCIHFAGTSCWGLIHVAVASRMTASVGSIQNFASFICASFAPIITGFI------------VDTTHSFRLALIICGCVTAA 434
Cdd:cd17504 283 IGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAIlttytvsitsggVPTEGAYVLAFLIGAALALA 362
|
....*...
gi 15834570 435 GALAYIFL 442
Cdd:cd17504 363 ALLLSLLI 370
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
58-438 |
9.48e-09 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 57.04 E-value: 9.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 58 RSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMV-------HSF 130
Cdd:cd17314 19 ILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSYVfnsfplsYAC 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 131 TQFVLVRIGMGIGeapmnpCGVKVINDWFnIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGVLGIF-L 209
Cdd:cd17314 99 FVFIGAGTGILYG------SAVLVTTQYF-PDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGILAAIvL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 210 AIGWYMLYRNREHV--ELTAVEQAYLNAGSVNarRDPLSFAEWRSLFRNRTMWGMMLGFSGinytawlYLAWLPGYLQTA 287
Cdd:cd17314 172 SVVSLLGFKEPPDNqaRLHVQKKKTQTMGEIF--RDKVFWILFIAIFLVLIGGFLFIANMA-------SLVRSLQLDAPS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 288 YnldlkSTGLMAAIPfLFGAAGMLVNGYVTDWLVKggmapiKSRKICIIAGMFCSAAFTLIVPQATTSMMAVLLIGMALF 367
Cdd:cd17314 243 F-----VTKLMSIYG-LFNAFGRLLWGIVADFFGG------RLSTLSILLTILGLGLCAFLFLLKMTPVGLVLTGSLLGF 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15834570 368 CIHFAGTSCWGLIHVAVASRMTASVGSIQNFASFICASFAPIITGFIVDTTHSFRLALIICG-CVTAAGALA 438
Cdd:cd17314 311 SYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAvIVFLASAIL 382
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
67-209 |
1.55e-08 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 56.43 E-value: 1.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 67 TIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAP 146
Cdd:cd17323 24 QIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSS 103
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15834570 147 MNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMF-ITIGVLGIFL 209
Cdd:cd17323 104 PLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFwFLAIISGFCL 167
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
44-182 |
1.56e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 56.14 E-value: 1.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 44 MLLLFFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAM 123
Cdd:COG2814 210 LLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLL 289
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 15834570 124 SGMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVS 182
Cdd:COG2814 290 LALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
44-209 |
6.70e-08 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 54.11 E-value: 6.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 44 MLLLFFAAvinyLDRSSLSVANLTIREELGlSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAM 123
Cdd:cd17502 2 MLALFLAA----LDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 124 SGMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMF---I 200
Cdd:cd17502 77 CGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFyinL 156
|
....*....
gi 15834570 201 TIGVLGIFL 209
Cdd:cd17502 157 PIGGLALAL 165
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
67-211 |
9.22e-08 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 54.13 E-value: 9.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 67 TIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKG--PRLMLGLGMFFWSLFqamsGM--VHSFTQFVLVRIGMGI 142
Cdd:PRK11043 31 AIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGrkPVLLAGLSLFALGSL----GMlwVESAAQLLVLRFVQAV 106
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15834570 143 GeapmnPCGVKVINDWFNIK--ERGRPMGFFnaaSTIG--VAVSP---PILAAMMLV-MGWRGMFITIGVLGIFLAI 211
Cdd:PRK11043 107 G-----VCSAAVIWQALVIDryPAQKANRVF---ATIMplVALSPalaPLLGAWLLNhFGWQAIFATLFAITLLLIL 175
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
68-221 |
1.10e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 53.72 E-value: 1.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 68 IREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDR--KGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEA 145
Cdd:COG2271 207 LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRlgRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLG 286
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15834570 146 PMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGVLGIFLAIGWYMLYRNRE 221
Cdd:COG2271 287 GAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
71-211 |
1.32e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 53.33 E-value: 1.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 71 ELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLML---GLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGeaPM 147
Cdd:cd17477 217 RLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLlgcALLGALAALLLPLVPGLPLALLVLLFLWGGAAG--PL 294
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15834570 148 NPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGVLGIFLAI 211
Cdd:cd17477 295 YTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLL 358
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
50-219 |
3.57e-07 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 51.88 E-value: 3.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 50 AAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHS 129
Cdd:cd17476 6 AQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPN 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 130 FTQFVLVRIGMGIGEAPMNPCGVKVINDWFNI-KERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGVLGIF 208
Cdd:cd17476 86 FIFFIICRALQGLGPAFLLPNAMALLGRTYPPgPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAI 165
|
170
....*....|..
gi 15834570 209 LAI-GWYMLYRN 219
Cdd:cd17476 166 VAVaAIFWTSPS 177
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
66-368 |
8.65e-07 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 51.09 E-value: 8.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 66 LTIREELGLSATEIGALLSVFsLAYGIA-QLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGE 144
Cdd:PRK15402 37 LAVVEDFNAGAEWVPTSMTAY-LAGGMFlQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 145 APMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGVLGiflAIGWYMLYRnrehve 224
Cdd:PRK15402 116 CFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALA---ALSFFGLWR------ 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 225 lTAVEQAylnagsvNARRDPLSFAE----WRSLFRNRTMWG--MMLGFSGINYTAWLYLAwlPGYLQTAYNLDLKSTGLM 298
Cdd:PRK15402 187 -AMPETA-------GRVGEKLSLKElgrdYKLVLKNRRFVAgaLALGLVSLPLLAWIALS--PVILISGEQLSSYEYGLL 256
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15834570 299 aAIPfLFGA--AGMLVNGYVTD-----WLVKGGMAPiksrkicIIAGMFCSAAFTLIVPQATTSMMAvlliGMALFC 368
Cdd:PRK15402 257 -QVP-VFGAliAGNLTLARLTSrrplrSLIRMGLWP-------MVAGLLLAALATVISSHAYLWLTA----GLSLYA 320
|
|
| OATP |
pfam03137 |
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ... |
74-349 |
9.71e-07 |
|
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.
Pssm-ID: 460821 [Multi-domain] Cd Length: 526 Bit Score: 51.05 E-value: 9.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 74 LSATEIGALLSVFSLAYGIAQLPCgplldrkgPRLmLGLGMFFWSLFQAMSGMVHsFTQFVLVRIGMGIGEAPMNPCGVK 153
Cdd:pfam03137 42 SSSYDIGNLLLIVFVSYFGGKGHR--------PRW-IGVGALLMGLGSLLFALPH-FLSFFLGQLLLGIGGTPIYTLGIS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 154 VINDwfNIKERGRPM--GFFNAASTIGVAVSPpILAAMMLVM----------------GWRGM----FITIGVLGIFLAI 211
Cdd:pfam03137 112 YIDD--NVKKKNSPLylGILYAVRVLGPALGF-LLGSLCLRIyvdigkvsitltpkdpRWVGAwwlgFLIAGLLLLLTAI 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 212 gWYMLY----RNREHVELTAVEQAYLNAGSVNARRDPLSFAEW---------RSLFRNRTMwgMMLGFSGINYTAWL--Y 276
Cdd:pfam03137 189 -PFFFFpkslPGAAKRRAKKKKEPHSQDIADLKKTKSLKKLGPslkdfpkalKRLLKNPVY--MLLTLASVFEFLLIagY 265
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15834570 277 LAWLPGYLQTAYNLDL-KSTGLMAAIPFLFGAAGMLVNGYVTDWLvkgGMAPIKSRKICIIAGMFCSAAFTLIV 349
Cdd:pfam03137 266 ATFLPKYIETQFGLSAsTANLLTGVVAIPGAALGILLGGLIIKKF---KLSAKGLAKFNVITSLVSLLLSLLLF 336
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
68-438 |
1.13e-06 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 50.65 E-value: 1.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 68 IREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQF---VLVRIGMGIGE 144
Cdd:cd17339 25 IRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLGGIALLFlgtALAGAGIAVGN 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 145 APMNPcgvkVINDWFNiKERGRPMG----FFNAASTIGVAVSPPILAAMMLvmGWRGMFITIGVLGIFLAIGWYMLYRNR 220
Cdd:cd17339 105 VLLPS----LIKRDFP-RRVGLMTGlyttSMNLGAALASGLSVPLAQALGG--GWRGALAIWALPALLALLIWLPQLRRR 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 221 EHVELTAVEQAYlnagsvnarrdplsfaewRSLFRNRTMWGMMLGFSGINYTAWLYLAWLPGYLQTAyNLDLKSTGLMAA 300
Cdd:cd17339 178 KRAAAAAAPLTK------------------ISVWRSPLAWQVTLFMGLQSLLFYTLMAWLPTILIDA-GLSAATAGWLLS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 301 I-----------------------PFLFGAAGMLVNGYVTDWLVKGGMAPIkSRKICIIAGMFC-SAAFTLIVPQATTSM 356
Cdd:cd17339 239 LfqlvgipasllvpilatrlknqrPIVVLLAVLFIIGVLGLLFAPTALALL-WAVLLGLGGGAAfSLALTLISLRSSDPA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 357 MAVLLIGMAlfcihfagtscwglihvavasrmtASVGsiqnfasFICASFAPIITGFIVDTTHSFRLALIICGCVTAAGA 436
Cdd:cd17339 318 EAAALSGMA------------------------QSVG-------YLLAALGPLLFGVLHDLTGSWTAPLVLLLALTVLQL 366
|
..
gi 15834570 437 LA 438
Cdd:cd17339 367 VA 368
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
69-222 |
1.21e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 50.62 E-value: 1.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 69 REELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAPMN 148
Cdd:COG0738 238 KDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMF 317
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15834570 149 PCGVKVINDWFNiKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGVLGIFLAIGWYMLYRNREH 222
Cdd:COG0738 318 PTIFSLALDGLG-KRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRK 390
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
43-218 |
1.21e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 50.67 E-value: 1.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 43 AMLLLFFAAVINYLDRSSL-SVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQ 121
Cdd:COG2211 229 PFLLLLLAYLLFFLALALVaALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGL 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 122 AMSGMV--HSFTQFVLVRIGMGIGEAPMNPCGVKVIND-------WFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLV 192
Cdd:COG2211 309 LLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADvvdydewKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLAL 388
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 15834570 193 MGW--------------RGMFITIGVLGIFLAIGWYMLYR 218
Cdd:COG2211 389 FGYvagaaqspsaltgiRLLFFLLPAVLLLLAALLLLFYP 428
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
68-224 |
1.97e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 49.88 E-value: 1.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 68 IREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGP-RLMLGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAP 146
Cdd:COG2223 232 LVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGrRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGG 311
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15834570 147 MNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMG-WRGMFITIGVLGIFLAIGWYMLYRNREHVE 224
Cdd:COG2223 312 GNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
15-183 |
2.08e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 49.72 E-value: 2.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 15 TPSSSADIPVPPDGLVQRSTRIKRIQTTAMLLLFFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQ 94
Cdd:pfam07690 173 PPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGR 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 95 LPCGPLLDRKGPR---LMLGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFF 171
Cdd:pfam07690 253 LLLGRLSDRLGRRrrlLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLY 332
|
170
....*....|..
gi 15834570 172 NAASTIGVAVSP 183
Cdd:pfam07690 333 NTAGSLGGALGP 344
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
79-211 |
2.38e-06 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 49.62 E-value: 2.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 79 IGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQF------VLVRIGMGIGEAPMNPCGV 152
Cdd:cd17342 65 LGVLDTIFLFSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWLHFynkylyCILWVLNGLLQSTGWPCVV 144
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 15834570 153 KVINDWFNIKERGRPMGFFNAASTIGvAVSPPILAAMMLVMGWRGMFITIGVLGIFLAI 211
Cdd:cd17342 145 AIMGNWFGKSSRGFVLGLWSACASVG-NIIGALLASSVLDYGYEYAFLVTSSLLFAGAI 202
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
67-211 |
5.48e-06 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 48.36 E-value: 5.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 67 TIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKG--PRLMLGLGMFFWSLFQAMsgMVHSFTQFVLVRI--GMGI 142
Cdd:PRK11652 33 DMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGrrPVILVGMSIFILGTLVAL--FAHSLTVLIAASAiqGLGT 110
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15834570 143 GEApmnpcGV---KVINDWFNikerGRPMGFFNAASTIGVAVSP---PILAAMMLVM-GWRGMFITIGVLGIFLAI 211
Cdd:PRK11652 111 GVG-----GVmarTLPRDLYE----GTQLRHANSLLNMGILVSPllaPLIGGLLTTLfGWRACYLFLLLLGAGVTF 177
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
47-441 |
6.09e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 48.09 E-value: 6.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 47 LFFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGM 126
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 127 VHSFTQFV----LVRIGMGIGEAPMNPCGVKVINdwfniKERGRPMGFFNAASTIGVAVSPPILAAMML-VMGWRGMFIT 201
Cdd:cd17333 81 TPSIYLFVvlmfLAGLGAGILDTGANTFVGALFE-----ESSATRLNVLHGFFGLGALIGPLIATSLLTsELSWSWAYLI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 202 IGVLGIFLAIGWYMLyrnrehvELTAVEQAYLNAGSVNARRDPLSfaewrSLFRNRTMWGMMLGFSGINYTAWLYLAWLP 281
Cdd:cd17333 156 IGLIYLLLAILILLT-------LFPELPSARNPQQSVGAFSASAS-----RLLRNPSIILGALALFLYVGAETAFSSWVP 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 282 GYLQTAYNLDLKSTGLMAAIPFLFGAAGMLVNGYVTDwlvkggmaPIKSRKICIIAGMFCSAAFTLIVPQATTSMMAVLL 361
Cdd:cd17333 224 SYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISR--------RIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVAT 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 362 IGMALFC-IHFAGTSCWGLIHVAVASrmtASVGSIQNFASFICASFAPIITGFIVDTThSFRLALIICGCVTAAGALAYI 440
Cdd:cd17333 296 ALLGLFMaALFPTILSLGISNLPYAK---GKGTSVLLAAGSIGGAIIPFIMGFIAEAV-GIQTAMLLITILYAIIFVLAL 371
|
.
gi 15834570 441 F 441
Cdd:cd17333 372 L 372
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
70-183 |
6.19e-06 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 47.99 E-value: 6.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 70 EELGLSATEIGALLSVfslaYGIAQLPCGPLL----DRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEA 145
Cdd:cd17390 24 RSLGASPTVIGLIGSV----YGALQLFSSPLVgswsDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKH 99
|
90 100 110
....*....|....*....|....*....|....*...
gi 15834570 146 PMNPCGVkVINDWFNIKERGRPMGFFNAASTIGVAVSP 183
Cdd:cd17390 100 TQSLCKA-YLSDLVSEQERSRVLGRFNAASSLGFILGP 136
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
257-452 |
6.20e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 48.36 E-value: 6.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 257 RTMWGMMLGFSGINYTAWLYLAWLPGYLQTAYNLDLKSTGLMAAIPFLFGAAGMLVNGYVTD-WLVKGGmapikSRKICI 335
Cdd:COG2211 10 KEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrTRTRWG-----RRRPWI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 336 IAGMFCSAAFTLIVPQA-TTSMMAVLLIGMALFCIHFAGTSCWGLIHVAVASRMT------ASVGSIQNFASFICASFAP 408
Cdd:COG2211 85 LIGAIPLALSFVLLFTApDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTpdyeerTRLSSWRFAFAGLGGLLAS 164
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 15834570 409 IITGFIV-----DTTHSFRLALIICGCVTAAGALAYIFLVRQPINDPRK 452
Cdd:COG2211 165 VLPPPLVaafggDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEE 213
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
78-442 |
6.35e-06 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 48.10 E-value: 6.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 78 EIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMF---FWSLFQAMSGMVHsFTQFVLVRIGMGIGEAPMNPCGVKV 154
Cdd:cd17382 50 TVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFvtsTLNMLIPIAARVH-YGCVIFVRILQGLVEGVTYPACHGI 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 155 INDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGVLGIFLAIGWYMLyrnrehveltaveqayln 234
Cdd:cd17382 129 WRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFWMLV------------------ 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 235 AGSVnarrdplsfaewrslfrnrtmWGMMLGFSGINYTAWLYLAWLPGYLQTAYNLDLKSTGLMAAIPFLFGAAGMLVNG 314
Cdd:cd17382 191 SMPV---------------------YAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 315 YVTDWL-VKGGMAPIKSRKICIIAGMFCSAAFTLIVPQATTSMMA----VLLIGMALFCIhfagtSCWGLIHVAVASRMT 389
Cdd:cd17382 250 QLADYLrSRGILSTTAVRKIFNCGGFGMEATFLLVVAFSHSPTVAisflVLAVGFSGFAI-----SGFNVNHLDIAPRYA 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 15834570 390 ASVGSIQNFASFICASFAPIITGFIV--DTTHSFRLALIICGCVTAAGALAYIFL 442
Cdd:cd17382 325 SILMGISNGIGTLSGMVCPVIVGALTkhKTREEWQYVFLIASLVHFFGVIFYAIF 379
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
45-216 |
6.78e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.95 E-value: 6.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 45 LLLFFAAVINYLDRSSLSvanLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMS 124
Cdd:cd17473 204 FLAFLAMLLFYVIPIQLP---FLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 125 GMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMM-LVMGWRGMFITIG 203
Cdd:cd17473 281 ALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVnLTGGLSGAFLILG 360
|
170
....*....|...
gi 15834570 204 VLGIFLAIGWYML 216
Cdd:cd17473 361 VLALVLAIVLLLL 373
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
23-213 |
1.40e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 47.15 E-value: 1.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 23 PVPPDGLVQRSTRIKRIQTTAMLLLFFAAVINYLDRSSLSVANLTIrEELGLSATEIGALLSVFSLAYGIAQLPCGPLLD 102
Cdd:cd17370 181 PRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFLILRA-QELGLSAALIPLLYALFNLVYALAAYPAGRLSD 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 103 RKGPRLMLGLGMFFWS----LFQAMSGMVHSFTQFVLVRIGMGIGEAPMNpcgvKVINDWFNIKERGRPMGFFNAASTIG 178
Cdd:cd17370 260 RIGRKKLLILGYLSLAlaylGFALGSSLWLLLLGFILWGLYMGAQESIER----AAVADLVPAELRGTAYGLFNTVVGIG 335
|
170 180 190
....*....|....*....|....*....|....*
gi 15834570 179 VAVSPPILAAMMLVMGWRGMFITIGVLGIFLAIGW 213
Cdd:cd17370 336 WLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
68-217 |
1.48e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 46.84 E-value: 1.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 68 IREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAPM 147
Cdd:cd17329 227 VVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLV 306
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 148 NPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGVLGIFLAIGWYMLY 217
Cdd:cd17329 307 FPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
43-190 |
2.10e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 46.40 E-value: 2.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 43 AMLLLFFAAVinyldrSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPR-------LMLGLGMF 115
Cdd:cd17321 176 AAFLLGAALG------GLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRlvlvaglLLTAVGLL 249
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15834570 116 FWSLFQAMSGMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDwfniKERGRPMGFFNAASTIGVAVSPPILAAMM 190
Cdd:cd17321 250 LLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPK----EKAGAASGILNTARQLGGALGVALLGALL 320
|
|
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
68-150 |
2.21e-05 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 46.46 E-value: 2.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 68 IREELGLSATEIGALlSVFSLAYGI-AQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAP 146
Cdd:PLN00028 62 IRDNLNLTKSDIGNA-GIASVSGSIfSRLAMGPVCDLYGPRYGSAFLLMLTAPAVFCMSLVSSATGFIAVRFFIGFSLAT 140
|
....
gi 15834570 147 MNPC 150
Cdd:PLN00028 141 FVSC 144
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
43-278 |
3.47e-05 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 45.97 E-value: 3.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 43 AMLLLFFAAvinYLDRSSLSVANLTIREELGLSATEIGALLSVFsLAYGIA-QLPCGPLLDRKGPRLMLGLGMFFWSLFQ 121
Cdd:PRK15403 20 ALILYDFAA---YLTTDLIQPGIINVVRDFNADVSLAPASVSLY-LAGGMAlQWLLGPLSDRIGRRPVLITGALIFTLAC 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 122 AMSGMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFIT 201
Cdd:PRK15403 96 AATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAI 175
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15834570 202 IGVLGIFLAIGwyMLYRNREHVELTAVEqayLNAGSVnarrdplsFAEWRSLFRNRTMW--GMMLGFSGINYTAWLYLA 278
Cdd:PRK15403 176 IAVMGLIAFVG--LLLAMPETVKRGAVP---FSAKSV--------LRDFRNVFRNRLFLtgAATLSLSYIPMMSWVAVS 241
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
262-446 |
3.96e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.41 E-value: 3.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 262 MMLGFSGINYTAWLYLAWLPGYLQTAYNLDLKSTGLMAAIPFLFGAAGMLVNGYVTDwlvkggmapIKSRKICIIAGMFC 341
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSD---------RFGRRRVLLIGLLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 342 SAAFTLIVPQATTSMMAVLLIGMALFCIHFAGTSCWGLIHVAVASRMTASVGSIQNFASFICASFAPIITGFIVDtTHSF 421
Cdd:pfam07690 72 FALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS-LFGW 150
|
170 180
....*....|....*....|....*
gi 15834570 422 RLALIICGCVTAAGALAYIFLVRQP 446
Cdd:pfam07690 151 RAAFLILAILSLLAAVLLLLPRPPP 175
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
68-369 |
4.61e-04 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 42.25 E-value: 4.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 68 IREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVLVRI----GMGIG 143
Cdd:cd17393 25 IKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFlfgaANGAL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 144 EAPMNPCGVKVindwfnIKERGRP-MGFFNAASTIGVAVSppilAAMMLVMGWRGmfitIGVLGIFLAIGWYMLyrnreh 222
Cdd:cd17393 105 DVAMNAQGVAV------ERAYGRPiMSSLHAMWSLGGLAG----ALLGAAAIGAG----VSPGVHLLAAAVLLL------ 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 223 VELTAVEQAYLNAGSVNARRDPLSFAEWRSLFRNR-------TMWGMMLGFSGINytawlylAWLPGYLQTAYNLDLKSt 295
Cdd:cd17393 165 LAALVAIRALLPGTGEAAEDRPDGAGKPGFLLPNRlllllglLALAAALAEGAAA-------DWSALYLRDVLGASAAL- 236
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15834570 296 glmAAIPFLFGAAGMLVNGYVTDWLVK--GGMAPIKSRKICIIAGMFCSaaftLIVPQATTSMMAVLLIGMALFCI 369
Cdd:cd17393 237 ---AALGYAVFSLAMTVGRLFGDRLVDrfGDVAVLRAGALLAALGLLLA----LLAPSVWVALAGFALMGLGLSVV 305
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
47-215 |
7.47e-04 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 41.99 E-value: 7.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 47 LFFAAVINYL----DRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQA 122
Cdd:PRK03893 21 AFSAAWLGYLldgfDFVLITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 123 MSGMVHSFTQFVLVRIGMGIGEA-PMNPCGVKVINDWfNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFIt 201
Cdd:PRK03893 101 ACGFAPGYWTLFIARLVIGMGMAgEYGSSATYVIESW-PKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFF- 178
|
170
....*....|....
gi 15834570 202 IGVLGIFLAigWYM 215
Cdd:PRK03893 179 IGILPIIFA--LWL 190
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
36-216 |
9.06e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.41 E-value: 9.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 36 IKRIQTTAMLLLFFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRK-GPRLMLGLGM 114
Cdd:cd17330 169 VLFFLPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRlGERKLLRLGL 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 115 FFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSpPILAAMMLVMG 194
Cdd:cd17330 249 LLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIG-PLLAGPLYSFL 327
|
170 180
....*....|....*....|..
gi 15834570 195 WRGMFITIGVLGIFLAIGWYML 216
Cdd:cd17330 328 GPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
70-414 |
2.25e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 40.28 E-value: 2.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 70 EELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVLVRIGmGIGEAPMnP 149
Cdd:cd17331 28 KKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRLP-SVFMHAM-Q 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 150 CGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGVLGIFLAIGWYMLYRNREHVELTAVE 229
Cdd:cd17331 106 AAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSNTKSKREKEA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 230 QAYLNAGSVnarrdpLSFAEWRSLFRNRTMWGMMLGFSGINYTAWLYLAWLPGYLQTAYNLDLKSTGLMAAipfLFGAAG 309
Cdd:cd17331 186 KESASPPSV------FNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMS---YAGVLG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 310 MLVNGYVTDWLVKGGmapikSRKICIIAGMFCSA-AFTLIVPQATTSMMAVLLIGMAlfcihFAGTscwgLIHVAVASRM 388
Cdd:cd17331 257 MVVQGLLVGPLTKRF-----GERSLLKLSVALLAiGYLLLAFVTTVWQLLVLLLPLV-----IGGS----VLYTVITSLL 322
|
330 340 350
....*....|....*....|....*....|....
gi 15834570 389 TASV-----GSIQNFA---SFICASFAPIITGFI 414
Cdd:cd17331 323 TKAVppedtGTALGLShalFSLVRTVSPTIGGAL 356
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
69-231 |
2.89e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 39.59 E-value: 2.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 69 REELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAPMN 148
Cdd:cd06180 26 LAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 149 PCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMM-LVMGWRGMFITIGVL-GIFLAIGWYMLYRNRE-HVEL 225
Cdd:cd06180 106 VFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLgGGLSWRAGWLALALLsAVLLLLSFLLLRRGPSaPTEA 185
|
....*.
gi 15834570 226 TAVEQA 231
Cdd:cd06180 186 SAAESA 191
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
48-443 |
3.90e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 39.56 E-value: 3.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 48 FFAAVINYLDRSSLSVANltirEELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPR---LMLGLGMFFWSLFQAMS 124
Cdd:pfam00083 21 AFLTLIDFFKNFGLSKSV----SSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKkslLIANVLFVIGAVLQGAA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 125 GMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVM---GWRGMFIT 201
Cdd:pfam00083 97 KGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSnsdGWRIPLGL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 202 IGVLGIFLAIGWYM-------LYRNREHVELTAV----EQAYLNAGSVNARRDPL------SFAEWRSLFRNRT------ 258
Cdd:pfam00083 177 QLVPALLLIIGLLFlpesprwLVEKGRLEEAREVlaklRGVPDVDRELDEIKDSLeagqeaEKASWKELFSTKTrrqrll 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 259 MWGMMLG---FSGINYTawLYLAwlPGYLQTA-YNLDLKSTGLMAAIPFLFGAAGMlvngyvtdWLV-KGGMapiksRKI 333
Cdd:pfam00083 257 IGVMLQIfqqLTGINAI--FYYS--TTIFENLgLSDSFLVTIIVGVVNFVFTFIAI--------FLVdRFGR-----RPL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 334 CII--AGMFCSAAF----TLIVPQATTSMMAVLLIGMALFCIHFA---GTSCWglIHVA------VASRMTASVGSIQNF 398
Cdd:pfam00083 320 LLLgaAGMAICFVIlgivALLGVSKSDWAGIVAIVFIALFIAFFAmgwGPVPW--VIVSelfplsVRSKAMALATAANWL 397
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 15834570 399 ASFICASFAPIITGFIvdttHSFRLALIICGCVTAAGALAYIFLV 443
Cdd:pfam00083 398 ANFLIGFLFPIITDAI----GLGYTFFIFAGLLVLFIIFVFFFVP 438
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
68-211 |
4.95e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.13 E-value: 4.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 68 IREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRK-GPRLMLGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAP 146
Cdd:cd17490 221 IAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYKKlGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGI 300
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15834570 147 MNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGVLGIFLAI 211
Cdd:cd17490 301 LFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAI 365
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
70-219 |
6.20e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 38.69 E-value: 6.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 70 EELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAPMNP 149
Cdd:cd17477 24 EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFV 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 150 CGVKVINDWFNIKERGRPMGFFNAASTIGVAVSpPILAAMMLVMGWRgMFITIGVLgIFLAIGWYMLYRN 219
Cdd:cd17477 104 VSESWLNALATNENRGRVLGLYSTVLGLGFALG-PLLLALVGTAGAL-PFLIAAVL-LLLALVPLLLTRR 170
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
72-440 |
6.85e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 38.33 E-value: 6.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 72 LGLSATEIGALLSVfslaYGIAQLPCGPLL----DRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAPM 147
Cdd:cd17330 29 LGASGYYVGLLQSS----YSLGQFLASPLWgrlsDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNV 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 148 NPCGVkVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGVLGIFLAIGwymlyrnrehvelta 227
Cdd:cd17330 105 SVAQA-YIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVL--------------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 228 veqaylnagsvnarrdplsfaewrSLFRNRTMWGMMLGFSGINYTAWLYLAWLPGYLQTAYNLDLKSTGLMAAIpflFGA 307
Cdd:cd17330 169 ------------------------VLFFLPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLAL---VGI 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 308 AGMLVNGyvtdwLVKGGMAPIKSRKICIIAGMFCSAAFTLIVPQATTSMMAVLLIGMALFCIHFAGTSCWGLIHVAVASR 387
Cdd:cd17330 222 AGILAQL-----LLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSK 296
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 15834570 388 MTASVGSIQNFASFICASFAPIITGFIVDTTHSFRLALIICGCVTAAGALAYI 440
Cdd:cd17330 297 EQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
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|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
84-219 |
7.34e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 38.33 E-value: 7.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 84 SVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKE 163
Cdd:cd17317 32 TIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKY 111
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 15834570 164 RGRPMGFFNAASTIGVAVSPPIlaaMMLVMGWRGMFITIGVLGIFLAIGWYMLYRN 219
Cdd:cd17317 112 RSFVGILFGLFWALGYMLLALL---AYLIRDWRWLQLAISLPGLLFLLLLWWLPRR 164
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
34-380 |
7.37e-03 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 38.76 E-value: 7.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 34 TRIKRIQTTAMLLLFFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLG 113
Cdd:PRK12307 10 SEITRPQKNALFSAWLGYVFDGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 114 MFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAPMNPCGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVM 193
Cdd:PRK12307 90 IVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAY 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 194 GWRGMFItIGVLGIFLAIgwYMLYRNREHVELtaVEQAYLNAGSVNARRDPLSFAEWRSLFRNR----TMWGMMLGFSgI 269
Cdd:PRK12307 170 GWRAAFF-VGLLPVLLVI--YIRARAPESKEW--EEAKLSGKGKHSQSAWSVFSLSMKGLFNRAqfplTLCVFIVLFS-I 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 270 NYTAWLYLAWLPGYLQ-TAYNLDLKSTgLMAAIPFlfgaagmlvnGYVTDWLVKGGMAPIKSRKICIIAGMFCSaaFTLI 348
Cdd:PRK12307 244 FGANWPIFGLLPTYLAgEGFDTGVVSN-LMTAAAF----------GTVLGNIVWGLCADRIGLKKTFSIGLLMS--FLFI 310
|
330 340 350
....*....|....*....|....*....|..
gi 15834570 349 VPQATTSMMAVLLIGMALFCIHFAGTSCWGLI 380
Cdd:PRK12307 311 FPLFRIPQDNYLLLGACLFGLMATNVGVGGLV 342
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
162-441 |
7.55e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 38.66 E-value: 7.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 162 KERGRPMGFFNAASTIGVAVSPPILAAMMLVM--------GWRGMFITIGVLgifLAIGWYMlyrnREHVELTAVEQAYL 233
Cdd:cd17369 137 KRRGFYGSFPQLGAPVGLLLATGVFLLLSALLsdeaflswGWRIPFLLSAVL---VAVGLYI----RLRLEETPVFRRAK 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 234 NAGSVnARRDPLSFaeWRSLFRNrtMWGMMLGFSGINYTAWLYLAWLPGYLQTAYNLDlKSTGLMA-AIPFLFGAAGMLV 312
Cdd:cd17369 210 EAGQV-VRAPLVEV--LRRHWRA--LLLAIGLRLAENVLFYLFTTFALSYATQTLGVD-RSTVLLAvLIASVVAAITIPL 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 313 NGYVTDWLvkggmapikSRKICIIAGMFCSA-----AFTLIVPQATT-SMMAVLLIGMALFCIHFAGTSCWGLIHVAVAS 386
Cdd:cd17369 284 FGWLSDRV---------GRRPVYLAGALLAAlfafpFFWLLDTGSTWlIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRV 354
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 15834570 387 RMT-ASVGsiQNFASFICASFAPIITGFIVDTTHSFRLALIICGCVTAAGALAYIF 441
Cdd:cd17369 355 RYTgASLG--YQLGAILGGGFAPLIATALVAATGSWWPVALYLAALAVISLVAALF 408
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
65-211 |
8.15e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 38.38 E-value: 8.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15834570 65 NLTIREELGLSATEIGALLSVFSLAYGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGE 144
Cdd:cd17313 269 TSAASSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGW 348
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15834570 145 APMNPCGVKVINDWFNIKER--GRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFI---TIGVLGIFLAI 211
Cdd:cd17313 349 ATININPYPLVSDYHSESGRgqGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPvaaVASFLSLVGAL 420
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