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Conserved domains on  [gi|16128213|ref|NP_414762|]
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NlpC/P60 family protein YafL [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

C40 family peptidase( domain architecture ID 11434971)

C40 family peptidase is a cell-wall hydrolase that cleaves peptide cross-bridges between glycan chains and is essential for bacterial growth and viability; typically cleaves the linkage between D-Glu and diaminopimelic acid (or Lys) within peptidoglycan stem peptides; contains a Cys-His-His catalytic triad

CATH:  3.90.1720.10
EC:  3.4.-.-
MEROPS:  C40
PubMed:  12620121|11517925

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
120-242 6.06e-45

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 150.23  E-value: 6.06e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128213 120 EVAIHRLEQQLGKPYVWGGTRPDkGFDCSGLVFYAYNK--IleaKLPRTANEMYHYRRAtiVANNDLRRGDLLFFHIHSR 197
Cdd:COG0791 101 EAIVAAALSYLGTPYVWGGTSPS-GFDCSGLVQYVYRQagI---SLPRTSADQAAAGTP--VSRSELQPGDLVFFRTGGG 174
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 16128213 198 EIaDHMGVYLGDGQFIESPRTGETIRISRLAEPFWQDHFLGARRI 242
Cdd:COG0791 175 GI-SHVGIYLGNGKFIHASSSGKGVRISSLDSPYWKSRYVGARRV 218
 
Name Accession Description Interval E-value
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
120-242 6.06e-45

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 150.23  E-value: 6.06e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128213 120 EVAIHRLEQQLGKPYVWGGTRPDkGFDCSGLVFYAYNK--IleaKLPRTANEMYHYRRAtiVANNDLRRGDLLFFHIHSR 197
Cdd:COG0791 101 EAIVAAALSYLGTPYVWGGTSPS-GFDCSGLVQYVYRQagI---SLPRTSADQAAAGTP--VSRSELQPGDLVFFRTGGG 174
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 16128213 198 EIaDHMGVYLGDGQFIESPRTGETIRISRLAEPFWQDHFLGARRI 242
Cdd:COG0791 175 GI-SHVGIYLGNGKFIHASSSGKGVRISSLDSPYWKSRYVGARRV 218
NLPC_P60 pfam00877
NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.
131-241 1.88e-42

NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.


Pssm-ID: 395705 [Multi-domain]  Cd Length: 105  Bit Score: 140.11  E-value: 1.88e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128213   131 GKPYVWGGTRPDkGFDCSGLVFYAYNKIlEAKLPRTANEMYHYRRATIVANnDLRRGDLLFFHIHSReiADHMGVYLGDG 210
Cdd:pfam00877   1 GVPYRWGGGSPS-GFDCSGLVRYAFAKV-GIELPRSSGQQYNAGKKTIPKS-EPQRGDLVFFGTGKG--ISHVGIYLGNG 75
                          90       100       110
                  ....*....|....*....|....*....|.
gi 16128213   211 QFIESPrTGETIRISRLAEPFWQDHFLGARR 241
Cdd:pfam00877  76 QMLHAS-TGGGVSISSLNGGYWQKRLVGVRR 105
PRK13914 PRK13914
invasion associated endopeptidase;
111-242 6.24e-14

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 70.60  E-value: 6.24e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128213  111 SSDHLHNITEVA-IHRLEQQLGKPYVWGGTRPDKgFDCSGLVFYAYNKIlEAKLPRTANEmyHYRRATIVANNDLRRGDL 189
Cdd:PRK13914 357 SSNNNSNSSASAiIAEAQKHLGKAYSWGGNGPTT-FDCSGYTKYVFAKA-GISLPRTSGA--QYASTTRISESQAKPGDL 432
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 16128213  190 LFFHIHSrEIAdHMGVYLGDGQFIESPRTGetIRISRLAEPFWQDHFLGARRI 242
Cdd:PRK13914 433 VFFDYGS-GIS-HVGIYVGNGQMINAQDNG--VKYDNIHGSGWGKYLVGFGRV 481
 
Name Accession Description Interval E-value
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
120-242 6.06e-45

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 150.23  E-value: 6.06e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128213 120 EVAIHRLEQQLGKPYVWGGTRPDkGFDCSGLVFYAYNK--IleaKLPRTANEMYHYRRAtiVANNDLRRGDLLFFHIHSR 197
Cdd:COG0791 101 EAIVAAALSYLGTPYVWGGTSPS-GFDCSGLVQYVYRQagI---SLPRTSADQAAAGTP--VSRSELQPGDLVFFRTGGG 174
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 16128213 198 EIaDHMGVYLGDGQFIESPRTGETIRISRLAEPFWQDHFLGARRI 242
Cdd:COG0791 175 GI-SHVGIYLGNGKFIHASSSGKGVRISSLDSPYWKSRYVGARRV 218
NLPC_P60 pfam00877
NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.
131-241 1.88e-42

NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.


Pssm-ID: 395705 [Multi-domain]  Cd Length: 105  Bit Score: 140.11  E-value: 1.88e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128213   131 GKPYVWGGTRPDkGFDCSGLVFYAYNKIlEAKLPRTANEMYHYRRATIVANnDLRRGDLLFFHIHSReiADHMGVYLGDG 210
Cdd:pfam00877   1 GVPYRWGGGSPS-GFDCSGLVRYAFAKV-GIELPRSSGQQYNAGKKTIPKS-EPQRGDLVFFGTGKG--ISHVGIYLGNG 75
                          90       100       110
                  ....*....|....*....|....*....|.
gi 16128213   211 QFIESPrTGETIRISRLAEPFWQDHFLGARR 241
Cdd:pfam00877  76 QMLHAS-TGGGVSISSLNGGYWQKRLVGVRR 105
PRK13914 PRK13914
invasion associated endopeptidase;
111-242 6.24e-14

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 70.60  E-value: 6.24e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128213  111 SSDHLHNITEVA-IHRLEQQLGKPYVWGGTRPDKgFDCSGLVFYAYNKIlEAKLPRTANEmyHYRRATIVANNDLRRGDL 189
Cdd:PRK13914 357 SSNNNSNSSASAiIAEAQKHLGKAYSWGGNGPTT-FDCSGYTKYVFAKA-GISLPRTSGA--QYASTTRISESQAKPGDL 432
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 16128213  190 LFFHIHSrEIAdHMGVYLGDGQFIESPRTGetIRISRLAEPFWQDHFLGARRI 242
Cdd:PRK13914 433 VFFDYGS-GIS-HVGIYVGNGQMINAQDNG--VKYDNIHGSGWGKYLVGFGRV 481
spr PRK10838
bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase;
131-244 7.90e-14

bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase;


Pssm-ID: 236773 [Multi-domain]  Cd Length: 190  Bit Score: 67.87  E-value: 7.90e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16128213  131 GKPYVWGGTRpDKGFDCSGLVFYAYNKILEAKLPRTANEMYHYRRAtiVANNDLRRGDLLFFHIHSReiADHMGVYLGDG 210
Cdd:PRK10838  79 GVRYRLGGST-KKGIDCSAFVQRTFREQFGLELPRSTYEQQEMGKS--VSRSKLRTGDLVLFRAGST--GRHVGIYIGNN 153
                         90       100       110
                 ....*....|....*....|....*....|....
gi 16128213  211 QFIESpRTGETIRISRLAEPFWQDHFLGARRILT 244
Cdd:PRK10838 154 QFVHA-STSSGVIISSMNEPYWKKRYNEARRVLS 186
YycO COG3863
Uncharacterized conserved protein YycO, NlpC/P60 family [Function unknown];
122-158 2.48e-03

Uncharacterized conserved protein YycO, NlpC/P60 family [Function unknown];


Pssm-ID: 443072  Cd Length: 166  Bit Score: 37.66  E-value: 2.48e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 16128213 122 AIHRLEQQLGKPYVWGGTRP--DKGFDCSGLVFYAYNKI 158
Cdd:COG3863  97 AANYAYSQVGKPYNYNFVKNvdDKKFYCSQLVWAAYKDA 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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