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Conserved domains on  [gi|16129363|ref|NP_415920|]
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IS2 insertion element protein InsB [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

transposase( domain architecture ID 11484104)

transposase binds to the end of a transposon and catalyzes the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism; similar to Escherichia coli transposase InsD

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK09409 PRK09409
IS2 transposase TnpB; Reviewed
1-301 0e+00

IS2 transposase TnpB; Reviewed


:

Pssm-ID: 181829 [Multi-domain]  Cd Length: 301  Bit Score: 612.49  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363    1 MDSARALIARGWGVSLVSRCLRVSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAE 80
Cdd:PRK09409   1 MDSARALIARGWGVSLVSRCLRVSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363   81 LDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHW 160
Cdd:PRK09409  81 LDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363  161 AVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTI 240
Cdd:PRK09409 161 AVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTI 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16129363  241 KRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNGLSDNRCLEI 301
Cdd:PRK09409 241 KRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNGLSDNRCLEI 301
 
Name Accession Description Interval E-value
PRK09409 PRK09409
IS2 transposase TnpB; Reviewed
1-301 0e+00

IS2 transposase TnpB; Reviewed


Pssm-ID: 181829 [Multi-domain]  Cd Length: 301  Bit Score: 612.49  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363    1 MDSARALIARGWGVSLVSRCLRVSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAE 80
Cdd:PRK09409   1 MDSARALIARGWGVSLVSRCLRVSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363   81 LDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHW 160
Cdd:PRK09409  81 LDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363  161 AVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTI 240
Cdd:PRK09409 161 AVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTI 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16129363  241 KRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNGLSDNRCLEI 301
Cdd:PRK09409 241 KRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNGLSDNRCLEI 301
transpos_IS3 NF033516
IS3 family transposase;
11-284 6.10e-67

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 213.20  E-value: 6.10e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363   11 GWGVSLVSRCLRVSRAQLHVILRRTddwmdgRRSRHTDDTDVLLRIHHVIGELP-TYGYRRVWALLRRQaeldGMPaINA 89
Cdd:NF033516 100 EYSVRRACRVLGVSRSTYYYWRKRP------PSRRAPDDAELRARIREIFEESRgRYGYRRITALLRRE----GIR-VNH 168
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363   90 KRVYRIMRQNALLLERKPAVPP--SKRAHTGRVA---------VKESNQRWCSDGFEFCCDNGeRLRVTFALDCCDREAL 158
Cdd:NF033516 169 KRVYRLMRELGLLARRRRKRRPytTDSGHVHPVApnllnrqftATRPNQVWVTDITYIRTAEG-WLYLAVVLDLFSREIV 247
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363  159 HWAVTTGgFNSETVQDVMLGAVERRFGndlpSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVK 238
Cdd:NF033516 248 GWSVSTS-MSAELVLDALEMAIEWRGK----PEGLILHSDNGSQYTSKAYREWLKEHGITQSMSRPGNCWDNAVAESFFG 322
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 16129363  239 TIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREY 284
Cdd:NF033516 323 TLKRECLYRRRFRTLEEARQAIEEYIEFYNHERPHSSLGYLTPAEF 368
Tra5 COG2801
Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];
14-291 3.53e-55

Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442053 [Multi-domain]  Cd Length: 309  Bit Score: 181.12  E-value: 3.53e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363  14 VSLVSRCLRVSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAEldgmpAINAKRVY 93
Cdd:COG2801  35 VSRRRRRLLRLLRRRRARSRRRRRLRRPRSYRADEDAELLERIKEIFAESPRYGYRRITAELRREGI-----AVNRKRVR 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363  94 RIMRQNALLLE-RKPAVPPSKRAHTGRVA------VKESNQRWCSDGFEFCCDNGeRLRVTFALDCCDREALHWAVTTGg 166
Cdd:COG2801 110 RLMRELGLQARrRRKKKYTTYSGHGGPIApnllftATAPNQVWVTDITYIPTAEG-WLYLAAVIDLFSREIVGWSVSDS- 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363 167 FNSETVQDVMLGAVERRFgndlPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYIS 246
Cdd:COG2801 188 MDAELVVDALEMAIERRG----PPKPLILHSDNGSQYTSKAYQELLKKLGITQSMSRPGNPQDNAFIESFFGTLKYELLY 263
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 16129363 247 IMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACN 291
Cdd:COG2801 264 RRRFESLEEAREAIEEYIEFYNHERPHSSLGYLTPAEYEKQLAAA 308
transpos_IS481 NF033577
IS481 family transposase; null
4-281 9.62e-21

IS481 family transposase; null


Pssm-ID: 468094 [Multi-domain]  Cd Length: 283  Bit Score: 89.57  E-value: 9.62e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363    4 ARALIARGWGVSLVSRCLRVSRAQLHVILRRTDDW-MDG--------RRSRHTDDTDVLLRIHHVIGELpTYGYRRVWAL 74
Cdd:NF033577   6 VRLVLEDGWSVREAARRFGISRKTVYKWLKRYRAGgEEGlidrsrrpHRSPRRTSPETEARILALRREL-RLGPRRIAYE 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363   75 LRRQAeldgmPAINAKRVYRIMRQNALllERKPAVPPsKRAHTGRVAVKESNQRWCSDGFEFC--CDNGeRLRVTFALDC 152
Cdd:NF033577  85 LERQG-----PGVSRSTVHRILRRHGL--SRLRALDR-KTGKVKRYERAHPGELWHIDIKKLGriPDVG-RLYLHTAIDD 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363  153 CDREALHWAVTTggFNSETVQDVMLGAVERRfgnDLPSSPVewLTDNGSCYRANET--RQFARMLGLEPKNTAVRSPESN 230
Cdd:NF033577 156 HSRFAYAELYPD--ETAETAADFLRRAFAEH---GIPIRRV--LTDNGSEFRSRAHgfELALAELGIEHRRTRPYHPQTN 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 16129363  231 GIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSP 281
Cdd:NF033577 229 GKVERFHRTLKDEFAYARPYESLAELQAALDEWLHHYNHHRPHSALGGKTP 279
rve_3 pfam13683
Integrase core domain;
215-281 1.59e-19

Integrase core domain;


Pssm-ID: 433402 [Multi-domain]  Cd Length: 67  Bit Score: 80.72  E-value: 1.59e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16129363   215 LGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSP 281
Cdd:pfam13683   1 LGIEISYIAPGKPMQNGLVESFNGTLRDECLNEHLFSSLAEARALLAAWREDYNTERPHSSLGYRTP 67
 
Name Accession Description Interval E-value
PRK09409 PRK09409
IS2 transposase TnpB; Reviewed
1-301 0e+00

IS2 transposase TnpB; Reviewed


Pssm-ID: 181829 [Multi-domain]  Cd Length: 301  Bit Score: 612.49  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363    1 MDSARALIARGWGVSLVSRCLRVSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAE 80
Cdd:PRK09409   1 MDSARALIARGWGVSLVSRCLRVSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363   81 LDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHW 160
Cdd:PRK09409  81 LDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363  161 AVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTI 240
Cdd:PRK09409 161 AVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTI 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16129363  241 KRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNGLSDNRCLEI 301
Cdd:PRK09409 241 KRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNGLSDNRCLEI 301
PRK14702 PRK14702
insertion element IS2 transposase InsD; Provisional
40-301 0e+00

insertion element IS2 transposase InsD; Provisional


Pssm-ID: 237792 [Multi-domain]  Cd Length: 262  Bit Score: 535.85  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363   40 DGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAELDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGR 119
Cdd:PRK14702   1 DGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAELDGMPAINAKRVYRLMRQNALLLERKPAVPPSKRAHTGR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363  120 VAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHWAVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDN 199
Cdd:PRK14702  81 VAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHWAVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363  200 GSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYR 279
Cdd:PRK14702 161 GSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYR 240
                        250       260
                 ....*....|....*....|..
gi 16129363  280 SPREYLRQRACNGLSDNRCLEI 301
Cdd:PRK14702 241 SPREYLRQRACNGLSDNRCLEI 262
transpos_IS3 NF033516
IS3 family transposase;
11-284 6.10e-67

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 213.20  E-value: 6.10e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363   11 GWGVSLVSRCLRVSRAQLHVILRRTddwmdgRRSRHTDDTDVLLRIHHVIGELP-TYGYRRVWALLRRQaeldGMPaINA 89
Cdd:NF033516 100 EYSVRRACRVLGVSRSTYYYWRKRP------PSRRAPDDAELRARIREIFEESRgRYGYRRITALLRRE----GIR-VNH 168
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363   90 KRVYRIMRQNALLLERKPAVPP--SKRAHTGRVA---------VKESNQRWCSDGFEFCCDNGeRLRVTFALDCCDREAL 158
Cdd:NF033516 169 KRVYRLMRELGLLARRRRKRRPytTDSGHVHPVApnllnrqftATRPNQVWVTDITYIRTAEG-WLYLAVVLDLFSREIV 247
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363  159 HWAVTTGgFNSETVQDVMLGAVERRFGndlpSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVK 238
Cdd:NF033516 248 GWSVSTS-MSAELVLDALEMAIEWRGK----PEGLILHSDNGSQYTSKAYREWLKEHGITQSMSRPGNCWDNAVAESFFG 322
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 16129363  239 TIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREY 284
Cdd:NF033516 323 TLKRECLYRRRFRTLEEARQAIEEYIEFYNHERPHSSLGYLTPAEF 368
Tra5 COG2801
Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];
14-291 3.53e-55

Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442053 [Multi-domain]  Cd Length: 309  Bit Score: 181.12  E-value: 3.53e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363  14 VSLVSRCLRVSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAEldgmpAINAKRVY 93
Cdd:COG2801  35 VSRRRRRLLRLLRRRRARSRRRRRLRRPRSYRADEDAELLERIKEIFAESPRYGYRRITAELRREGI-----AVNRKRVR 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363  94 RIMRQNALLLE-RKPAVPPSKRAHTGRVA------VKESNQRWCSDGFEFCCDNGeRLRVTFALDCCDREALHWAVTTGg 166
Cdd:COG2801 110 RLMRELGLQARrRRKKKYTTYSGHGGPIApnllftATAPNQVWVTDITYIPTAEG-WLYLAAVIDLFSREIVGWSVSDS- 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363 167 FNSETVQDVMLGAVERRFgndlPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYIS 246
Cdd:COG2801 188 MDAELVVDALEMAIERRG----PPKPLILHSDNGSQYTSKAYQELLKKLGITQSMSRPGNPQDNAFIESFFGTLKYELLY 263
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 16129363 247 IMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACN 291
Cdd:COG2801 264 RRRFESLEEAREAIEEYIEFYNHERPHSSLGYLTPAEYEKQLAAA 308
transpos_IS481 NF033577
IS481 family transposase; null
4-281 9.62e-21

IS481 family transposase; null


Pssm-ID: 468094 [Multi-domain]  Cd Length: 283  Bit Score: 89.57  E-value: 9.62e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363    4 ARALIARGWGVSLVSRCLRVSRAQLHVILRRTDDW-MDG--------RRSRHTDDTDVLLRIHHVIGELpTYGYRRVWAL 74
Cdd:NF033577   6 VRLVLEDGWSVREAARRFGISRKTVYKWLKRYRAGgEEGlidrsrrpHRSPRRTSPETEARILALRREL-RLGPRRIAYE 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363   75 LRRQAeldgmPAINAKRVYRIMRQNALllERKPAVPPsKRAHTGRVAVKESNQRWCSDGFEFC--CDNGeRLRVTFALDC 152
Cdd:NF033577  85 LERQG-----PGVSRSTVHRILRRHGL--SRLRALDR-KTGKVKRYERAHPGELWHIDIKKLGriPDVG-RLYLHTAIDD 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363  153 CDREALHWAVTTggFNSETVQDVMLGAVERRfgnDLPSSPVewLTDNGSCYRANET--RQFARMLGLEPKNTAVRSPESN 230
Cdd:NF033577 156 HSRFAYAELYPD--ETAETAADFLRRAFAEH---GIPIRRV--LTDNGSEFRSRAHgfELALAELGIEHRRTRPYHPQTN 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 16129363  231 GIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSP 281
Cdd:NF033577 229 GKVERFHRTLKDEFAYARPYESLAELQAALDEWLHHYNHHRPHSALGGKTP 279
rve_3 pfam13683
Integrase core domain;
215-281 1.59e-19

Integrase core domain;


Pssm-ID: 433402 [Multi-domain]  Cd Length: 67  Bit Score: 80.72  E-value: 1.59e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16129363   215 LGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSP 281
Cdd:pfam13683   1 LGIEISYIAPGKPMQNGLVESFNGTLRDECLNEHLFSSLAEARALLAAWREDYNTERPHSSLGYRTP 67
rve pfam00665
Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into ...
125-227 1.17e-18

Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.


Pssm-ID: 459897 [Multi-domain]  Cd Length: 98  Bit Score: 79.28  E-value: 1.17e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363   125 SNQRWCSDGFEFCCDNGE-RLRVTFALDCCDREALHWAVTTGGfNSETVQDVMLGAVERRFGndlpsSPVEWLTDNGSCY 203
Cdd:pfam00665   1 PNQLWQGDFTYIRIPGGGgKLYLLVIVDDFSREILAWALSSEM-DAELVLDALERAIAFRGG-----VPLIIHSDNGSEY 74
                          90       100
                  ....*....|....*....|....
gi 16129363   204 RANETRQFARMLGLEPKNTAVRSP 227
Cdd:pfam00665  75 TSKAFREFLKDLGIKPSFSRPGNP 98
PHA02517 PHA02517
putative transposase OrfB; Reviewed
21-294 2.27e-14

putative transposase OrfB; Reviewed


Pssm-ID: 222853 [Multi-domain]  Cd Length: 277  Bit Score: 71.82  E-value: 2.27e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363   21 LRVSRAQLHVILRRTDDwMDGRRSRHTDDTDVLLRIHHVIGE-LPTYGYRRVWallrRQAELDGMpAINAKRVYRIMRQN 99
Cdd:PHA02517   1 LGIAPSTYYRCQQQRHH-PDKRRARAQHDDWLKSEILRVYDEnHQVYGVRKVW----RQLNREGI-RVARCTVGRLMKEL 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363  100 ALlleRKPAVPPSKRAHTGRVAVK------------ESNQRWCSDgFEFCCDNGERLRVTFALDCCDREALHWAVTtggF 167
Cdd:PHA02517  75 GL---AGVLRGKKVRTTISRKAVAapdrvnrqfvatRPNQLWVAD-FTYVSTWQGWVYVAFIIDVFARRIVGWRVS---S 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129363  168 NSETvqDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYISI 247
Cdd:PHA02517 148 SMDT--DFVLDALEQALWARGRPGGLIHHSDKGSQYVSLAYTQRLKEAGIRASTGSRGDSYDNAPAESINGLYKAEVIHR 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 16129363  248 MPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPRE----YLRQRACNGLS 294
Cdd:PHA02517 226 VSWKNREEVELATLEWVAWYNNRRLHERLGYTPPAEaekaYYASIGNNDVA 276
HTH_21 pfam13276
HTH-like domain; This domain contains a predicted helix-turn-helix suggesting a DNA-binding ...
64-102 1.44e-07

HTH-like domain; This domain contains a predicted helix-turn-helix suggesting a DNA-binding function.


Pssm-ID: 463824 [Multi-domain]  Cd Length: 60  Bit Score: 47.56  E-value: 1.44e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 16129363    64 PTYGYRRVWALLRRQAELdgmpAINAKRVYRIMRQNALL 102
Cdd:pfam13276  19 GTYGYRRITAELRREGGI----RVNRKRVARLMRELGLR 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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