|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
14-394 |
8.08e-175 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 493.40 E-value: 8.08e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 14 AVLCIYFSYFLHGISVITLAQNMSSLAEKFSTDNAGIAYLISGIGLGRLISILFFGVISDKFGRRAVILMAVIMYLLFFF 93
Cdd:cd17396 1 TALGLYFNYFVHGMGVIILAQNMSSLSEKWHTDVAGVAYVISGIGIGRLLTILFAGVLSDKFGRKPSVLLGMVLYALFFV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 94 GIPACPNLTLAYGLAVCVGIANSALDTGGYPALMECFPKASGSAVILVKAMVSFGQMFYPMLVSYMLLNNIWYGYGLIIP 173
Cdd:cd17396 81 GILFSPNLIIAYVFALLAGAANSFLDTGTYPALMEAFPKASGSANILVKAFVSFGQFLLPFIIAFLAANNLWYGWSFIVP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 174 GILFVLITLMLLKSKFPSQLVDASVT--NELPQMNSKPLVWLEGVSSVLFGVAAFSTFYVIVVWMPKYAMAFAGMSEAEA 251
Cdd:cd17396 161 AAVLVLNALLLLKLSFPPQTVTAANTkqKEIPVKREKPKFLIEGIALILIGFTSTATFYLFSQWMPKYGSAVAGMGEAES 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 252 LKTISYYSMGSLVCVFIFAALLKKMVRPIWANVFNSALATITAAIIYLYPSPLVCNAGAFVIGFSAAGGILQLGVSVMSE 331
Cdd:cd17396 241 LKLISYYSMGSLVCVFITAVLLKRYVRPIWILVLYPIISLLALFVLYLVPSPDVCILGAFVIGFFAAGGVLQLGLTLMAE 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226524719 332 FFPKSKAKVTSIYMMMGGLANFVIPLITGYL-SNIGLQYIIVLDFTFALLALITAIIVFIRYYR 394
Cdd:cd17396 321 FFPKGKGKVTGIYMIASSLANFVIPLITGIIaSAIGIAYIFLFDFGIALLGLLLAIFVFIRYRK 384
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
19-387 |
5.30e-41 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 149.39 E-value: 5.30e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 19 YFSYFLHGISVITLAQNMSSLAEKFSTDNAGIAYLISGIGLGRLISILFFGVISDKFGRRAVILMAVIMYLLFFFGIPAC 98
Cdd:cd17333 2 YISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFAT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 99 PNLTLAYGLAVCVGIANSALDTGGYPALMECFPKASGSAVILVKAMVSFGQMFYPMLVSYMLLNNIWYGYGLIIPGILFV 178
Cdd:cd17333 82 PSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 179 LITLMLLKSKFPsQLVDASVTNELPQMNSKPLVWLEGVSSVLFGVAAFSTFYV----IVVWMPKYAMAFAGMSEAEALKT 254
Cdd:cd17333 162 LLAILILLTLFP-ELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGaetaFSSWVPSYLVEKKHVSDGLAGYL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 255 ISYYSMGSLVCVFIFAALLKKMVrpIWANVFNSALATITAAIIYLYPSPLVCNAGAFVIGFSAAGGILQLGVSVMSEFFP 334
Cdd:cd17333 241 LSGFWVGITIGRLLGGPISRRIK--PHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLP 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 226524719 335 KSKAKVTSIYMMMGGLANFVIPLITGYLSN-IGLQYIIVLDFTFALLALITAII 387
Cdd:cd17333 319 YAKGKGTSVLLAAGSIGGAIIPFIMGFIAEaVGIQTAMLLITILYAIIFVLALL 372
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
8-388 |
1.68e-28 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 115.34 E-value: 1.68e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 8 STPFILAVLCIYFSYFLHGISVITLAQNMSSLAEKFSTDNAGIAYLISGIGLGRLISILFFGVISDKFGRRAVILMAVIM 87
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 88 YLLFFFGIPACPNLTLAYGLAVCVGIANSALDTGGYPALMECFPKASGSAVILVKAMVSFGQMFYPMLVSYMLLNNI--W 165
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLslS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 166 YGYGLIIPGILFVLITLMLLKSKFPSQLVDASVTNE----LPQMNSKPLVWLeGVSSVLFGVAAFSTFYvivVWMPKYAM 241
Cdd:COG0738 163 WHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGsaasLKSLLKNPRLLL-GGLAIFLYVGAEGAIG---DWLPLYLK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 242 AFAGMSEAEALKTISYYSMGSLVCVFIFAALLKKmVRPIWANVFNSALATITAAIIYLYPSPLVCNAGAFVIGFSAAgGI 321
Cdd:COG0738 239 DVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKR-FGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLS-LM 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226524719 322 LQLGVSVMSEFFPKSKAKVTSIYMMMGGLANFVIPLITGYLSN-IGLQYIIVLDFTFALLALITAIIV 388
Cdd:COG0738 317 FPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADaFGLRAAFLVPLVCYLLILLLALAL 384
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
13-394 |
1.47e-18 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 86.46 E-value: 1.47e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 13 LAVLCIYFSYFLHGISVITLAQNMSSLAEKFSTDNAGIAYLISGIGLGRLISILFFGVISDKFGRRAVILMAVIMYLLFF 92
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 93 FGIPACPNLTLAYGLAVCVGIANSALDTGGYPALMECFPKAS-GSAVILVKAMVSFGQMFYPMLVSYMLLNNIWYG--YG 169
Cdd:COG2271 90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKErGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAafLI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 170 LIIPGILFVLITLMLLkskfpsqlvdasvtnelpqmnskplvwlegvssVLFGVAAFSTFYVIVVWMPKYAMAFAGMSEA 249
Cdd:COG2271 170 LGLPGLLLALLRFWLL---------------------------------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 250 EALKTISYYSMGSLVCVFIFAALLKKMVRP-IWANVFNSALATITAAIIYLYPSPLVCNAGAFVIGFsAAGGILQLGVSV 328
Cdd:COG2271 217 QAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGF-GLGGAFGLLWAL 295
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226524719 329 MSEFFPKSK-AKVTSIYMMMGGLANFVIPLITGYLSNI-GLQYIIVLDFTFALLALITAIIVFIRYYR 394
Cdd:COG2271 296 AAELFPKKArGTASGLVNTFGFLGGALGPLLVGYLLDAtGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-352 |
6.48e-17 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 81.56 E-value: 6.48e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 1 MSQNKAFSTPFILAVLCIYFSYFLhGISVITLAqnMSSLAEKFSTDNAGIAYLISGIGLGRLISILFFGVISDKFGRRAV 80
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGL-GIGIVLPA--LPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 81 ILMAVIMYLLFFFGIPACPNLTLAYGLAVCVGIANSALDTGGYPALMECFPKAS-GSAVILVKAMVSFGQMFYPMLVSYM 159
Cdd:COG2814 78 LLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERrGRALGLLGAGLGLGPALGPLLGGLL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 160 LLNNIWYGYGLIIPGILFVLITLMLLKSKFPSQLVDASVTNELPQMNSKPLVWLegvsSVLFGVAAFSTFYVIVVWMPKY 239
Cdd:COG2814 158 ADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLL----LLLLAFLLGFGFFALFTYLPLY 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 240 AMAFAGMSEAEALKTISYYSMGSLVCVFIFAALLKKMVRPIWAnVFNSALATITAAIIYLYPSPLVCNAGAFVIGFSAAG 319
Cdd:COG2814 234 LQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLL-LIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGL 312
|
330 340 350
....*....|....*....|....*....|...
gi 226524719 320 GILQLGVSVMSEFFPKSKAKVTSIYMMMGGLAN 352
Cdd:COG2814 313 LFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
39-394 |
9.61e-17 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 81.47 E-value: 9.61e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 39 LAEKFSTDNAGIAYLISGIGLGRLISILFFGVISDKFGRRAVILMAVIMYLLFFFGIPACPNLTLAYGLAVCVGIANSAL 118
Cdd:COG2223 31 LAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 119 DTGGYPALMECFPKAS-GSAVILVKAMVSFGQMFYPMLVSYMLLNNIWYGYGLIIPGILFVLITLMLLKSKFPSQLVDAS 197
Cdd:COG2223 111 FAVGIALVSKWFPPDRrGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAA 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 198 VTNELPQMN---SKPLVWLegvsSVLFGVAAFSTFYVIVVWMPKYAMAFAGMSEAEALKTISYYSMGSLVCVFIFAALLK 274
Cdd:COG2223 191 AKASLRDQLealRDPRFWL----LSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSD 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 275 KMVRPIWANVFNSALATITAAIIYLYPSPLVCNAGAFVIGFSAAGGILQLGVSVMSEFFPKSKAKVTSIYMMMGGLANFV 354
Cdd:COG2223 267 RIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFL 346
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 226524719 355 IPLITGYLSNIGLQYIIVLdFTFALLALITAIIVFIRYYR 394
Cdd:COG2223 347 GPLLFGALLDATGSYTAAF-LVFAVLALVALVLTLLLYRR 385
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
18-356 |
3.63e-15 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 76.30 E-value: 3.63e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 18 IYFSYFLHGISVITLAQNMSS-LAEKFSTDNAGIAYLISGIGLGRLISILFFGVISDKFGRRAVILMAVIMYLLFFFGIP 96
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 97 ACPNLTLAYGLAVCVGIANSALDTGGYPALMECFPKA-SGSAVILVKAMVSFGQMFYPMLVSYMLLNNIWYGYGLIIPGI 175
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEeRGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 176 LFVLITLMLLK-SKFPSQLVDASVTNELPQMNSKPLVWLEGVSSVLFGVAAFST-FYVIVVWMPKYAMAFaGMSEAEALK 253
Cdd:pfam07690 161 SLLAAVLLLLPrPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFaFFGLLTYLPLYQEVL-GLSALLAGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 254 TISYYSMGSLVCVFIFAALLKKM--VRPIWANVFNSALATITAAIIYLYPSPLVCNAGAFVIGFSAAGGILQLGVSVMSE 331
Cdd:pfam07690 240 LLGLGGLLGAIGRLLLGRLSDRLgrRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDL 319
|
330 340
....*....|....*....|....*
gi 226524719 332 FFPKSKAKVTSIYMMMGGLANFVIP 356
Cdd:pfam07690 320 APKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
18-389 |
2.53e-14 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 74.00 E-value: 2.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 18 IYFSYFLHGISVITLAQNMSSLAEKFSTDNAGIAYLISGIGLGRLISILFFGVISDKFGRRAVILMAVIMYLLFFFGIPA 97
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 98 CPNLTLAYGLAVCVGIANSALDTGGYPALMECFPKASGSAVILVKAMVS-----FGQMFYPMLVSYMLLNNIWYGYGLII 172
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGsvggiLGPLLGGILASSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 173 PGILFVLITLMLLKSKFPSQLVDASVTNELPQMNSKPLVWLEG--VSSVLFGVAAFSTFYVIVVWMPKYAMAFAGMSEAE 250
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPglWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 251 ALKTISYYSMGSLVCVFIFAALLKKMVRPIWANVFNSALATITAAIIYLYPSPLVCNAGAFVIGFSAAGGILQLGVSVMS 330
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 226524719 331 EFFPKSKAKVTSIYMMMGGLANFVIPLITGYLSNIGLQYIIVLdFTFALLALITAIIVF 389
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAF-LVLAVLLLLAAILLL 378
|
|
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
19-388 |
7.28e-14 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 72.65 E-value: 7.28e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 19 YFSYFLHGISVITLAQNMSSLAEKFSTDNAGIAYLISGIGLGRLISILFFGVISDKFGRRAVILMAVIMYLLFFFGIPAC 98
Cdd:PRK03699 13 FLSYALTGALVIVTGMVMGPIAEYFNLPVSSMSNTFTFLNAGILISIFLNAWLMEIIPLKRQLIFGFALMILAVAGLMFS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 99 PNLTLAYGLAVCVGIANS-ALDTGGYPALMECFPKASGSAVILVKAMVSFGQMFYPMLVSYMLLNNIWYGYGLIIPGILF 177
Cdd:PRK03699 93 HSLALFSIAMFVLGVVSGiTMSIGTFLITHVYEGKQRGSRLLFTDSFFSMAGMIFPIIAAYLLARSIEWYWVYACIGLVY 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 178 VLITLMLLKSKFPsQLVDASVTNELPQMNSKplvWleGVSSVLFGVAAFSTF---YVIVVWMPKYAMAFAGMSEAEALKT 254
Cdd:PRK03699 173 VAIFILTLFSEFP-ALGKHAPKADKPVAKEK---W--GIGVLFLAIAALLYIlaqLTFISWVPEYAQKKFGMSLEDAGNL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 255 ISYYSMGSLVCVFIFAALLKKMvRPIWANVFNSALATITAAIIYLYPSPLVCNAGAFVIGFSAAgGILQLGVSVMSEFFP 334
Cdd:PRK03699 247 VSNFWMAYMVGMWIFSFIVRFF-DLQRILTVLAGLALVLMYLFVNTDDPSHLLYAILGLGFFSS-AIYTTIITLGSQQTK 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 226524719 335 KSKAKVTSIYMMMGGLANFVIPLITGYL-SNIGLQ---YIIVLDFTFALLALITAIIV 388
Cdd:PRK03699 325 VASPKLVNFILTCGTIGTMLTFVVTSPIvAHFGLQaalLTANGLYAVVFVMCILLGFV 382
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
46-390 |
5.36e-11 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 63.74 E-value: 5.36e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 46 DNAGIAYLISGIGLGRLISILFFGVISDKFGRRAVILMAVIMYLLFFFGIPACPNLTLAYGLAVCVGIANSALDTGGYPA 125
Cdd:COG2807 51 SATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 126 LMECFPKASGSAVILVKAMVSFGQMFYPMLVSYMLLNNIWYGY--GLIIPGILFVLITLMLLKSKfPSQLVDASVTNELP 203
Cdd:COG2807 131 IKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGAlaVWALLALLALLLWLPLLRRR-PAAAAAAPAAASLR 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 204 QMNSKPLVWLegvSSVLFGVAAFsTFYVIVVWMPKYAMAfAGMSEAEALKTISYYSMGSLVCVFIFAALLKKMVRPIWAN 283
Cdd:COG2807 210 SLWRSPLAWL---LTLFFGLQSL-LYYAVVAWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLL 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 284 VFNSALATITAAIIYLYPSPLVCnAGAFVIGFsAAGGILQLGVSVMSEFFPKSK--AKVTSIYMMMGGLANFVIPLITGY 361
Cdd:COG2807 285 LLLGLLGLAGLLGLLLAPGSLPW-LWAVLLGL-GQGGLFPLALTLIGLRARTPAeaAALSGMAQSVGYLLAALGPLLVGA 362
|
330 340
....*....|....*....|....*....
gi 226524719 362 LSNIGLQYIIVLdFTFALLALITAIIVFI 390
Cdd:COG2807 363 LHDATGSWTAAL-LLLAALAVLMLVAGLL 390
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
50-391 |
3.79e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 61.05 E-value: 3.79e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 50 IAYLISGIGLGRLISILFFGVISDKFGRRAVILMAVIMYLLFFFGIPACPNLTLAYGLAVCVGIANSALDTGGYPALMEC 129
Cdd:cd17473 37 VPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDY 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 130 FPKASGSAVI-LVKAMVSFGQMFYPMLVSYMLL---NNIWYGYGLIIPGILFVLITLmllkskfPSQLVDASVTNELPQM 205
Cdd:cd17473 117 FEGEERAKMLgLQSAAMSLGGVVFLLLGGALAEigwRAPFLVYLLALPVLILVLLFL-------PEPARKSKSAASPGAA 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 206 NSKPLVWLEGVSSVLFGVAAFSTFYVIVVWMPKYAMAFAGMSEAEALKTISYYSMGSLVcVFIFAALLKKMVRPIWANVF 285
Cdd:cd17473 190 TAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAI-GALLFGRLKRRLGKRRLLAI 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 286 NSALATITAAIIYLYPSPLVCNAGAFVIGFSAAGGILQLGVSVMSEFFPKSKAKVTSIYMMMGGLANFVIPLITGYLSNI 365
Cdd:cd17473 269 GFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNL 348
|
330 340
....*....|....*....|....*.
gi 226524719 366 GLQYIIVLDFTFALLALITAIIVFIR 391
Cdd:cd17473 349 TGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
18-386 |
2.99e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 58.38 E-value: 2.99e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 18 IYFSYFLHGISVITLAQNMSSLAEKFS--TDNAGIAYLISGIGLGRLISILFFGVISDKFGRRAVILMAVIMYLLFFFGI 95
Cdd:cd17316 4 AGLGWFFDAYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 96 PACPNLTLAYGLAVCVGIANSALDTGGYPALMECFPKASGSAVILVKAMVSFGQMFYPMLVSYMLLNNIWYGYGLIIPGI 175
Cdd:cd17316 84 GLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 176 LFVLITLMLLkskfpsqlvdasvtnelpqmnskpLVWLEGVSSVLFGVAAFSTFYVIVVWMPKYAMAFAGMSEAEALKTI 255
Cdd:cd17316 164 IGALPALLAL------------------------LLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 256 SYYSMGSLVCVFIFAALLKKMVRPIWANVFNSALATITAAIIYLYPSPLVCNAGAFVIGFSAAGGILQLGVSVMSEFFPK 335
Cdd:cd17316 220 LLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPT 299
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 226524719 336 S-KAKVTSIYMMMGGLANFVIPLITGYL--SNIGLQYIIVLDFTFALLALITAI 386
Cdd:cd17316 300 EvRATGVGLSYNLGRLGGGGAPPLIALLlaSTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
18-389 |
5.09e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 57.59 E-value: 5.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 18 IYFSYFLHGISVITLAQNMSSLAEKFSTDNAGIAYLISGIGLGRLISILFFGVISDKFGRRAVILMAVIMYLLFFFGIPA 97
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 98 CPNLTLAYGLAVCVGIANSALDTGGYPALMECFPKAS-GSAVILVKAMVSFGQMFYPMLVSYmLLNNIWYGYGLIIPGIL 176
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEErGRAMGIFSSAIGLGFLIGPLLGGL-LADALGYRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 177 FVLITLMLLKSKFPSQLVDASVTNELPQMNSKPLVWLEGVSSVLFGVAAFSTFYVIVVW---MPKYAMAFAGMSEAEALK 253
Cdd:cd17325 160 ALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALepfLPLYAAELGGLSPAQIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 254 TISYYSMGSLVCVFIFAALLKKMVRPIWAnVFNSALATITAAIIYLYPSPLVCNAGAFVIGFSAAGGILQLGVSVMSEFF 333
Cdd:cd17325 240 LFGAQGLASALSQPPAGKLSDRIGRKPLI-LIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVP 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 226524719 334 PKSKAKVTSIYMMMGGLANFVIPLITGYLS-NIGLQYIIVLDFTFALLALITAIIVF 389
Cdd:cd17325 319 PEGRGTAMGLFNTAFSLGMVLGPLLGGFLYdAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
12-292 |
2.53e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 54.82 E-value: 2.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 12 ILAVLCIYFSYFLHGISVITLAQNMSSLAEKFSTDNAGIAYLISGIGLGRLISILFFGVISDKFGRRAVILMAVIMYLLF 91
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 92 FFGIPACPNLTLAYGLAVCVGIANSALDTGGYPALMECFPKAS-GSAVILVKAMVSFGQMFYPMLVSYMLLNNIW-YGYG 169
Cdd:COG0477 93 SLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARErGRALGLWGAAIGLGLALGPLLGGLLVAALGWrWIFL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 170 LIIPGILFVLITLMLLKSKFPSQLVDASVTNELPQMNSKPLVWLEGVSSVLFGVAAFSTFYVIVVWMPKYAMAFAGMSEA 249
Cdd:COG0477 173 INAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLL 252
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 226524719 250 EALKTISYYSMGSLVCVFIFAALLKKMVRPIWANVFNSALATI 292
Cdd:COG0477 253 LLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
38-391 |
1.88e-07 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 52.57 E-value: 1.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 38 SLAEKFSTDNAGIAYLISGIGLGRLISILFFGVISDKFGRRAVILMAVIMYLLFFFGIPACPNLTLAYGLAVCVGIANSA 117
Cdd:cd17474 24 AIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 118 LDTGGYPALMECFP-KASGSAVILVKAMVSFGQMFYPMLVSymLLNNIWY-----GYGLIIPgILFVLITLMLLKSKFPS 191
Cdd:cd17474 104 LGPLALTLIGDLFEgGERAKAMGLYEAALGLGIAVGPLLGG--LLAAISWrypffLLAALIP-VAFLAILFLLPEPKEKA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 192 QLVDASVTNELPQMNSKPLVWLEGVSSVLFgvaaFSTFYVIVVWMPKYAMAFAGMSEAEALKTISYYSMGSLVCVFIFAA 271
Cdd:cd17474 181 KSSSATKLRDLKKALRGRGLLTFLVSAFLY----FFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 272 LLKKMVRPIWANVFNSALATITAAIIYLYPSPLVCNAGAFVIGFSAAGGILQLGVSVMSEFFPKSKAKVTSIYMMMGGLA 351
Cdd:cd17474 257 LLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLG 336
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 226524719 352 NFVIPLITGYLSNIGLqyIIVLDFTFALLALITAIIVFIR 391
Cdd:cd17474 337 QAVGPLLFGLLLEIFG--LSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
59-186 |
2.93e-07 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 51.81 E-value: 2.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 59 LGRLISILFFGVISDKFGRRAVILMAVIMYLLFFFGIPACPNLTLAYGLAVCVGIANSALDTGGYPALMECF-PKASGSA 137
Cdd:cd17317 36 LGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVgPKYRSFV 115
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 226524719 138 VILVKAMVSFGQMFYPmLVSYMLLNNIWYGYGLIIPGILFVLITLMLLK 186
Cdd:cd17317 116 GILFGLFWALGYMLLA-LLAYLIRDWRWLQLAISLPGLLFLLLLWWLPR 163
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
36-386 |
5.98e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 51.01 E-value: 5.98e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 36 MSSLAEKFSTDNAGIAYLISGIGLGRLISILFFGVISDKFGRRAVILMAVIMYLLFFFGIPACPNLTLAYGLAVCVGIAN 115
Cdd:cd17324 22 LPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAH 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 116 SALDTGGYPALMECFPKAS-GSAVILVKAMVSFGQMFYPMLVSYM--LLNNIWYGYGLIIPGILFVLITLMLLKSKFPSQ 192
Cdd:cd17324 102 GGFWAIAAAYAADLVPPEKrGRAIGLVFSGLTLGLVLGRPLGGLLgqLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 193 LVDASVTNELPQMNSKPLVWLegvsSVLFGVAAFSTFYVIVVWMPKYAMAFAGMSEAEALKTISYYSMGSLVCVFIFAAL 272
Cdd:cd17324 182 PGSLGLLSSLLLLLRNPRLRL----AYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 273 LKKMVRPIWAnVFNSALATITAAIIYLYPSPLVCNAGAFVIGFsAAGGILQLGVSVMSEFFPKSKAKVTSIYMMMGGLAN 352
Cdd:cd17324 258 ADRGGRRALL-IALLLLAAALLLLTLLGPSPLLLLVGLVLWGL-GFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGG 335
|
330 340 350
....*....|....*....|....*....|....*
gi 226524719 353 FVIPLITGY-LSNIGLQYIIVLDFTFALLALITAI 386
Cdd:cd17324 336 ALGAALGGLvLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
39-389 |
9.16e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 50.63 E-value: 9.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 39 LAEKFSTDNAGIAYLISGIGLGRLISILFFGVISDKFGRRAVILMAVIMYLLFFFGIPACPNLTLAYGLAVCVGIANSAL 118
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 119 DTGGYPALMECFPKASGSAVILVKAMVSFGQMFYPMLVSYmLLNNIWYGYGLIIPGILFVLITLMLLKSKFPSQLVDASV 198
Cdd:cd17478 102 HPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAA-LVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 199 TNELPQMNSKPLVWleGVSSVLFGVAAFSTFYV--IVVWMPKYAMAfAGMSEAEALKTISYYSMGSLVCVFIFAALLKKM 276
Cdd:cd17478 181 AAKSSARSTLKGVW--RALLLLLIIVFLRSWVLssLTTFLPFYLVQ-RGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRF 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 277 VRpiwANVFNSALATITAAIIYLYPSPLVCNAGAFVIGFSAAGGILQLGVSVMSEFFPKSKAKVTSIYMMMGGLANFVIP 356
Cdd:cd17478 258 GR---RRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLASGLMMGLSFGLGGIGA 334
|
330 340 350
....*....|....*....|....*....|....
gi 226524719 357 LITGYLSNI-GLQYIIVldfTFALLALITAIIVF 389
Cdd:cd17478 335 PVLGALADAfGLESVLL---ILALLPLLGALLAF 365
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
66-391 |
1.61e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 49.92 E-value: 1.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 66 LFFGVISDKFGRRAV-----ILMAVIMYLLFFFGIPACPNLTLAYGLAVCVGIANSALDTGGYPALMECFPKAS-GSAVI 139
Cdd:cd06173 52 PFAGVLADRFDRRRLliladLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQlVRANA 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 140 LVKAMVSFGQMFYPMLVSYmLLNNIWYGYGLIIPGILFVLITLMLLKSKFPSQLVDASVTNELPQMNSKPLVWLEG---V 216
Cdd:cd06173 132 LNSLATQLARIIGPALGGL-LVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRsplL 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 217 SSVLFGVAAFSTFY-VIVVWMPKYAMAFAGMSEAEALKTISYYSMGSLVcVFIFAALLKKMVRPIWANVFNSALATITAA 295
Cdd:cd06173 211 RLLLLALALFALLGgALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALL-GALLLGRLSKRRRRGRLLLIGALLLGLALL 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 296 IIYLYPSPLVCNAGAFVIGFSAAGGILQLGVSVMSEFFPKSKAKVTSIYMMMGGLANFVIPLITGYLSN-IGLQYIIVLd 374
Cdd:cd06173 290 VLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADaLGLSAVFLL- 368
|
330
....*....|....*..
gi 226524719 375 ftFALLALITAIIVFIR 391
Cdd:cd06173 369 --AGALLLLAALLLLLL 383
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
18-120 |
1.92e-06 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 49.56 E-value: 1.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 18 IYFSYFLHGISVITLAQNMSSLAEKFSTDNAGIAYLISGIGLGRLISILFFGVISDKFGRRAVILMAVIMYLLFFFGIPA 97
Cdd:cd17393 4 VAAFFFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGL 83
|
90 100
....*....|....*....|...
gi 226524719 98 CPNLTLAYGLAVCVGIANSALDT 120
Cdd:cd17393 84 APSVPALALALFLFGAANGALDV 106
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
12-362 |
2.93e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 49.28 E-value: 2.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 12 ILAVLCIYFSYFLHGISVITLAQNMSSLAEKFSTDNAGIAYLISGIGLGRLISILFFGVISDKFGRRAVILMAVIMYLLF 91
Cdd:TIGR00895 16 WRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 92 FFGIPACPNLT--LAYGLAVCVGIAnsaldtGGYPALME-----CFPKASGSAVILVKAMVSFGQMFYPMLVSYMLLNNI 164
Cdd:TIGR00895 96 TLLCALATNVTqlLILRFLAGLGLG------GLMPNLNAlvseyAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 165 WYG---YGLIIPGILFVLITLML------LKSKFPSQL----------VDASVTNELPQMNSKPLVWLEGVSSVLFGVAA 225
Cdd:TIGR00895 170 WRSlfyVGGIAPLLLLLLLMRFLpesidfLVSKRPETVrrivnaiapqMQAEAQSALPEQKSTQGTKRSVFKALFQGKTA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 226 FST-------------FYVIVVWMPKYaMAFAGMSEAEALKTISYYSMGSLVCVFIFAALLKKMVRPIWANVFnsALATI 292
Cdd:TIGR00895 250 RITvllwllyfmllvgVYFLTNWLPKL-MVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLL--LLGAV 326
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 226524719 293 TAAIIYL-YPSPLVCNAGAFVIGFSAAGGILQLGVSvMSEFFPkSKAKVTSIYMM--MGGLANFVIPLITGYL 362
Cdd:TIGR00895 327 FAVLVGStLFSPTLLLLLGAIAGFFVNGGQSGLYAL-MALFYP-TAIRATGVGWAigIGRLGAIIGPILAGYL 397
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
12-185 |
6.74e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.95 E-value: 6.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 12 ILAVLCIYFSYFLHGISVITLAQNMSS-LAEKFSTDNAGIAYLISGIGLGRLISILFFGVISDKFGRRAVILMAVIMYLL 90
Cdd:cd17473 196 WKRVLPIYFLAFLAMLLFYVIPIQLPFlLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMAL 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 91 FFFGIPACPNLTLAYGLAVCVGIANSALDTGGYPALMECFPKA-SGSAVILVKAMVSFGQMFYPMLVSYMLLNNIWYGYG 169
Cdd:cd17473 276 GFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPElRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGA 355
|
170
....*....|....*.
gi 226524719 170 LIIPGILFVLITLMLL 185
Cdd:cd17473 356 FLILGVLALVLAIVLL 371
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
18-363 |
1.10e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 47.27 E-value: 1.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 18 IYFSYFLHGISVITLAQNMSSLAEKFSTDNAGIAYLISGIGLGRLISILFFGVISDKFGRRAVILMAVIMYLLFFFGIPA 97
Cdd:cd17312 8 VFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 98 CPNLTLAYGLAVCVGIANSAldtgGYPALMECF-----PKASGSAVILVKAMVSFGQMFYPMLVSYMLLNNIWyGYGLII 172
Cdd:cd17312 88 STSLWFFAVLWGLNGLFQSM----GWPPCVKLLgnwfsKKERGTVYGIWSTSHNFGGILAPILAASLASYYGW-RAAFLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 173 PGILFVLITLMLLKSkfpsqlvdasvtnelpQMNSKPLVWLEGVSSVLFGVAAfstfYVIVVWMPKYAMAFAGMSEAEAL 252
Cdd:cd17312 163 PGIVGLVVAIILFFF----------------LRDSPPYVWVLSLAYAFVYIVR----YACLDWGPLYLYEVKGYSLIDAG 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 253 KTISYYSMGSLVCVFIFAALLKKMV--RPIWANVFNSALATITAAIIYLYPSPLVCNAGA-FVIGFSAAGGILQLGVsVM 329
Cdd:cd17312 223 WFSSLYEVGGIAGTILAGLLSDKLFggRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLlFLIGFFVGGPINLIGG-AA 301
|
330 340 350
....*....|....*....|....*....|....*.
gi 226524719 330 SEFFPKSKA--KVTSIYMMMGGLANFVIPLITGYLS 363
Cdd:cd17312 302 AQDIGRKEAagTATGFVGLFGYLGASLAGLPLGYII 337
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
19-362 |
2.74e-05 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 45.83 E-value: 2.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 19 YFSYFLHGISVITLAQNMSSLAEKFSTDNAGIAYLISGIGLGRLISILFFGVISDKFGRRAVILMAVIMYLLFFFGIPAC 98
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 99 PNLTLAYGLAVCVGIANSALDTGGYPALMECFPKAS-GSAVILVKAMVSFGQMFYPMLVSY---MLLNNIWygyGLIIPG 174
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSErGTWVSFWNCSHNVGGGLLPPLVLFgiaELYSWHW---VFIVPG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 175 ILFVLITLMLLK--------------SKFPSQLVDASVTNELPQMNSKPLVWLEGVSSVLFGVAAFSTFYVIVV------ 234
Cdd:TIGR00881 158 IIAIIVSLICFLllrdspqscglppaEEMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVrtgild 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 235 WMPKYAMAFAGMSeaeALKTISYYSM-------GSLVCVFIFAALLKKMVRPIwaNVFNSALATITAAIIYLYP--SPLV 305
Cdd:TIGR00881 238 WSPLYLTQEKGFS---KEKASWAFTLyelgglvGTLLAGWLSDKLFNGRRGPL--AVFFMALIIVSLLVYWLNPaaNPLM 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 226524719 306 CNAGAFVIGFSAAGGILQLGVSVMSEFFPKSKAKVTSIYMMMGGLANFVIPLITGYL 362
Cdd:TIGR00881 313 DLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYL 369
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
15-390 |
4.17e-05 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 45.25 E-value: 4.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 15 VLCIYFSYFLHGISVITLAQNMSSLAEKFSTDNAGIAYLISGIGLGRLISILFFGVISDKFGRRAVILMAVIMYLLFFFG 94
Cdd:cd17319 5 IPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTAL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 95 IPACPNLTLAYGLAVCVGIANSALDTGGYPALMECFPKAS-GSAVILVKAMVSFGQMFYPMLVSYMLLNNIWYGYGLI-- 171
Cdd:cd17319 85 TGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARErGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIeg 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 172 IPGILFVLITLMLLKSkfpsqlvdasvtnelpqmnskplVWLegvsSVLFGVAAFSTFYVIVVWMPKYAMAFAGMSeaea 251
Cdd:cd17319 165 LLGLLLAVLWWFYLRQ-----------------------VWG----LALGYFGINYALYGLLTWLPTYLKQARGFS---- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 252 LKTISYYSmgSLVCVFIFAALLKKMVRPIWANVFNSALATIT---AAIIYLYPSPLVCNAGAFVIGFSAAGGILQLGVSV 328
Cdd:cd17319 214 LKQVGLLA--AIPFLAGAIGMILGGRLSDRLLRGARRLVIIIgllLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPV 291
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226524719 329 M----SEFFPKSK-AKVTSIYMMMGGLANFVIPLITGYLSNIGLQYIIVLdFTFALLALITAIIVFI 390
Cdd:cd17319 292 FwslpADLLPGEAaATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAF-LFLAAVALLAALLVLL 357
|
|
| MFS_MFSD4 |
cd17395 |
Major facilitator superfamily domain-containing protein 4; The Major facilitator superfamily ... |
22-192 |
1.54e-04 |
|
Major facilitator superfamily domain-containing protein 4; The Major facilitator superfamily domain-containing protein 4 (MFSD4) subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The MFSD4 subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340953 [Multi-domain] Cd Length: 367 Bit Score: 43.67 E-value: 1.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 22 YFLHGISVITLAQNMSSLAEKFSTDNAGIAYLISGIGLGRLISILFFGVISDKFGRRAVILMAVIMYLLFFFGIPACPNL 101
Cdd:cd17395 6 FFSFGLSIAFLGPTLLDLACNTNSSLPQISWVFFSRQLGYLLGSALGGVFKRTLNSLWALFTSSLLIALVLAVIPFCKDV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 102 TLAYGLAVCVGIANSALDTGGYPALMECFPKASGSAVILVKAMVSFGQMFYPMLVSYMLLNNIWYGYGLIIPGILFVlit 181
Cdd:cd17395 86 KVLASVMAIAGLAMGCLDTGANMQIVRMWQKDSAPFLQVLHFSFGFGAFLAPLIADPFLSYAYWIMALINLPVPMAV--- 162
|
170
....*....|.
gi 226524719 182 LMLLKSKFPSQ 192
Cdd:cd17395 163 LMLLSKERLLT 173
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
31-335 |
2.07e-04 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 43.38 E-value: 2.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 31 TLAQNMSSLAEKFSTdnAGIAYLISGIGLGRLISILFFGVISDKFGRRAVILMAVIMYLLFFFGIPACPNLTLAYGLAVC 110
Cdd:cd17345 23 SLAQPYLIEQYGLSK--TEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSATSSVGLMFI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 111 VGIANSALDTGGYPA----LMECFP-KASGSAVILVKAMVSFGQMFYPMLV--SYMLLNNIWYGYGLIIPGIL---FVLI 180
Cdd:cd17345 101 LLFLNGWFQGMGWPPsgrtMVHWFSkKERGTWTSIWNISHNVGGGLVGPLAglGLAIFGDGWWRGAFIFPAIIaiiVAVI 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 181 TLMLLKSK------------FPSQLVDASVTNELPQMNSK----------PLVWLegvsSVLFGVAAFSTFYVIVVWMPK 238
Cdd:cd17345 181 VLFLGKDTpeseglppieeyKGDYPEEADGEEEEQELSAWeifvkyvlknKLLWY----IAIANVFVYLVRYGILDWAPT 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 239 YAMAFAGMSEAEALKTISYYSM----GSLVCVFIfAALLKKMVRPIWANVFnsaLATITAAII--YLYPSPLVCNAGAFV 312
Cdd:cd17345 257 YLSEVKGFSKAQAMWAFSLFEWaaipGTLLAGWL-SDKLFKGRRAPTGIIF---MILVIVALIvyWLAPNVLVDLIALIA 332
|
330 340
....*....|....*....|...
gi 226524719 313 IGFSAAGGILQLGVSVMsEFFPK 335
Cdd:cd17345 333 LGFLIYGPVMLIGLQAL-ELVPK 354
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
39-388 |
1.64e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 40.30 E-value: 1.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 39 LAEKFSTDNAGIAYLISGIGLGRLISILFFGVISDKFGRRAVI-----LMAVIMYLLFFFGipacpNLTLAYGLAVCVGI 113
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLavgllLMGAAALLMALVG-----SYPVLLVLLFLVGA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 114 ANSALDTGGYPALMECFPKAS-GSAVILVKAMVSFGQMFYPMLVSYMLLNNIWYGyGLIIPGILFVLITLMLL------K 186
Cdd:cd17475 97 GYGSVQPGGGRAIMRWFPPRErGLAMGIRQTGVPLGGALAAALLPPLALHYGWRA-AFVVAGLVSILAAVLFWlfyrepP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 187 SKFPSQLVDASVTNELPQMNSKPLVWLEGVSSVLFGVAAfstfYVIVVWMPKYAMAFAGMSeaeaLKTISYYsmgsLVCV 266
Cdd:cd17475 176 AASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQ----FALLTFLLLFLHDHLGLS----VVAAGAL----LAVA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 267 FIFAALLK-------------KMVRPIWANVFNSALATITAAIIYLYPSPLVCNAGAFVIGFSAAG--GilqLGVSVMSE 331
Cdd:cd17475 244 QLGGALGRiglgrvsdrvfggRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGwnG---LYLTLVAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 226524719 332 FFPKSKA-KVTSIYMMMGGLANFVIPLITGYLSNIGLQYIIVLdFTFALLALITAIIV 388
Cdd:cd17475 321 SAGPEQAgTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAW-LALALLLVLAALLL 377
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
205-388 |
2.14e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.96 E-value: 2.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 205 MNSKPLVWLEGVSSVLFGVAAFST-FYVIVVWMPKYAMAFaGMSEAEALKTISYYSMGSLVCVFIFAALLKKmVRPIWAN 283
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLgIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADR-FGRRRVL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 284 VFNSALATITAAIIYLYPSPLVCNAGAFVIGFsAAGGILQLGVSVMSEFFPKSK-AKVTSIYMMMGGLANFVIPLITGYL 362
Cdd:COG2814 79 LLGLLLFALGSLLCALAPSLWLLLAARFLQGL-GAGALFPAALALIADLVPPERrGRALGLLGAGLGLGPALGPLLGGLL 157
|
170 180
....*....|....*....|....*..
gi 226524719 363 SN-IGLQYIIVLDFTFALLALITAIIV 388
Cdd:COG2814 158 ADlFGWRWVFLVNAVLALLALLLLLRL 184
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
59-179 |
2.23e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 40.00 E-value: 2.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 59 LGRLISILFFGVISDKFGRRAVILMAVIMYLLFFFGIPACPNLTLAYGLAVCVGIANSALDTGGYPALMECFP-KASGSA 137
Cdd:TIGR00898 138 VGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPkKQRAIV 217
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 226524719 138 VILVKAMVSFGQMFYPmLVSYMLLNNIWYGYGLIIPGILFVL 179
Cdd:TIGR00898 218 GTLIQVFFSLGLVLLP-LVAYFIPDWRWLQLAVSLPTFLFFL 258
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
38-393 |
5.32e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 38.70 E-value: 5.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 38 SLAEKFSTDNAGIAYLISGIGLGRLISILFFGVISDKFGRRAVILMAVIMYLLFFFGIPACPNLTLAYGLAVCVGIANSA 117
Cdd:cd17359 26 FLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 118 LDTGGYPALMECFPKAS-GSAVILVKAMVSFGQM--------FYPMLVSYMLLNNIW-YGYGL-IIPGILFVLITLMLLK 186
Cdd:cd17359 106 ASALVPMYIAEVAPAEIrGRLVSLNQLMIVFGQLlayivnylIANAGGADWLGAEGWrWMLGLeAIPAILFLLGMLFIPE 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 187 SkfPSQLVdasvtnelpqMNSKPLVWlegvssVLFGVAAFSTFYVIVVWMpKYA---MAFAGMSEAEALKTISYYSMGSL 263
Cdd:cd17359 186 S--PRWLV----------SKGKPILI------IGIGLAIFQQFVGINVIF-YYGpeiFQNAGFSENAALLQTIGIGVVNV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 264 VCVFIFAALLKKMVRPIWANVFNSALATITAAIIYLYPSPLVCNAGAFVIGFSAAGGILQLGVS-------VMSEFFP-K 335
Cdd:cd17359 247 IFTIIAILLVDKVGRKPLLLIGSIGMAISLLLIGTAFYFAPGSQASGIVALVLILLFVAFFAMSwgpvtwvLLSEIFPnR 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 226524719 336 SKAKVTSIYMMMGGLANFVIplitGYLSNIgLQYIIVLDFTFALLALITAI-IVFIRYY 393
Cdd:cd17359 327 IRGLAMGIAVFFLWIANFLV----SLTFPI-LLAAFGLAFTFLIFAVICVLaFLFVWKF 380
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
17-111 |
6.25e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 38.75 E-value: 6.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 17 CIYFSYFLHGISVITLAQNMSSLAEKFSTDNAGIAYLISGI-----GLGRLisilFFGVISDKFGRRAVILMAVIMYLLF 91
Cdd:cd17353 217 LLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSIlsifnGGGRP----FWGWLSDKIGRKNTLSIAFLIQGVA 292
|
90 100
....*....|....*....|
gi 226524719 92 FFGIPACPNLTLAYGLAVCV 111
Cdd:cd17353 293 MFLLPFIGSVAVLFVLGVAL 312
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
36-388 |
6.60e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 38.33 E-value: 6.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 36 MSSLAEKFSTDNAGIAYLISGIGLGRLISILFFGVISDKFGRRAVILMAVIMYLLFFFGIPACPNLTLAYGLAVCVGIAN 115
Cdd:cd17320 22 LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 116 SALDTGGYPALMECFPKASGSAVI-LVKAMVSFGQMFYPMLVSYMLLNNIWYG--YGLIIPGILFVLITLMLLKSKFPSQ 192
Cdd:cd17320 102 AAGSVVARAIVRDLYSGAELAKIFsLLMMILAIAPALAPLLGGLLLLFFGWRAifVFLALLGLLLLLLVLLFLPETLPEE 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 193 lvdasvtNELPQMNSKPLVWLEGVSS------VLFGVAAFSTFYVIVVWMPKYAMAFAGMSEAEALKTISYYSMGSLVCV 266
Cdd:cd17320 182 -------KRKPLLSSLLRAYKRVLKNrrflgyALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGS 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 267 FIFAALLKK------MVRPIWANVFNSALATITAAIIYLYPSPLVCNAGAFVIGFSAAGGILqlgVSVMSEFFPKSKAKV 340
Cdd:cd17320 255 LLNGRLVRRfgprrlLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNA---TSLALEPFPHVAGTA 331
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 226524719 341 TSIYMMMGGLANFVIPLITGYLSNIGLQYIIVLDFTFALLALITAIIV 388
Cdd:cd17320 332 SALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
19-386 |
9.27e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 38.05 E-value: 9.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 19 YFSYFLHGISVITLAQNMSSLAEKFSTDNAGIAYLISGIGLGRLISILFFGVISDKFGRRAVILMAVIMYLLFFFGIPAC 98
Cdd:cd17371 5 FLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 99 PNLTLAYGLAVCVGIANSALDTGGYPALMECFP-KASGSAVILVKAMVSFGQMF----YPMLVSYMLLNNIWygYGLIIP 173
Cdd:cd17371 85 QNYWQLLILRALAGLGFGGEWAAGAALMAEYVPaRHRGKALGYVQSGWAVGWLLatllAALLFPLLPPEIAW--RVLFLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 174 GILFVLITLML-LKSKFPSQLVDASVTNELPQ-------MNSKPLVWLEGVSSVLFGVAAFsTFYVIVVWMPKYAMAFAG 245
Cdd:cd17371 163 GALPALLVLFIrRFVKEPPQWQAARAARRHFAdrpslreLFSPPLLRTTLLASLLATGALG-GYYGITTWLPSYLTGERG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226524719 246 MSEAEALKTISYYSMGSLVCVFIFAALLKKMVRPiWANVFNSALATITAAIIYLYP-SPLVCNAGAFVIGFSaAGGILQL 324
Cdd:cd17371 242 LSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRR-NNFALFALGSAISILLYFFLPlSPTLILILGFPLGFF-ASGPFSG 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226524719 325 GVSVMSEFFPKS-KAKVTSIYMMMGGLANFVIPLITGYL-SNIGLQYIIVLDFTFALLALITAI 386
Cdd:cd17371 320 MGAYLTELFPTAvRATAQGFCYNVGRIIGALFPFLVGFLaTSGSLGTAIAVFAAVYYIAGLVLA 383
|
|
| |
