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Conserved domains on  [gi|16130242|ref|NP_416810|]
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lysine/arginine/ornithine ABC transporter/histidine ABC transporter, membrane subunit HisM [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

ABC transporter permease( domain architecture ID 10794130)

ABC transporter permease is part of the histidine ABC transporter complex, and is also a part of a lysine/arginine/ornithine transporter

Gene Ontology:  GO:0055052|GO:0022857
PubMed:  26517919

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK15069 PRK15069
histidine ABC transporter permease HisM;
1-234 9.18e-164

histidine ABC transporter permease HisM;


:

Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 451.81  E-value: 9.18e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242    1 MIEILHEYWKPLLWTDGYRFTGVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYS 80
Cdd:PRK15069   1 MIEILQEYWKALLWTDGYRFTGLAITLWLLVASVVIGFVLAVPLAIARVSSNKWIRFPVWLYTYVFRGTPLYVQLLVFYT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242   81 GMYTLEIVKGTEFLNAFFRSGLNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYRCIILPSALRIAL 160
Cdd:PRK15069  81 GMYSLEIVRGTDLLDAFFRSGLNCTILAFTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRAL 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16130242  161 PAYSNEVILMLHSTALAFTATVPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKRWLQHVKP 234
Cdd:PRK15069 161 PAYSNEVILMLHATTLAFTATVPDILKIARDINSATYQPFQAFGIAAVLYLIISFVLISLFRRAERRWLAHLKP 234
 
Name Accession Description Interval E-value
PRK15069 PRK15069
histidine ABC transporter permease HisM;
1-234 9.18e-164

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 451.81  E-value: 9.18e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242    1 MIEILHEYWKPLLWTDGYRFTGVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYS 80
Cdd:PRK15069   1 MIEILQEYWKALLWTDGYRFTGLAITLWLLVASVVIGFVLAVPLAIARVSSNKWIRFPVWLYTYVFRGTPLYVQLLVFYT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242   81 GMYTLEIVKGTEFLNAFFRSGLNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYRCIILPSALRIAL 160
Cdd:PRK15069  81 GMYSLEIVRGTDLLDAFFRSGLNCTILAFTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRAL 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16130242  161 PAYSNEVILMLHSTALAFTATVPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKRWLQHVKP 234
Cdd:PRK15069 161 PAYSNEVILMLHATTLAFTATVPDILKIARDINSATYQPFQAFGIAAVLYLIISFVLISLFRRAERRWLAHLKP 234
ArtM COG4160
ABC-type arginine/histidine transport system, permease component [Amino acid transport and ...
 2-236 1.84e-107

ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443325 [Multi-domain]  Cd Length: 229  Bit Score: 308.95  E-value: 1.84e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242   2 IEILHEYWkPLLWTdgyrftGVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYSG 81
Cdd:COG4160   3 LDLLFEYL-PLLLS------GLPLTLQLLALSLLLGFLLAVPLALARASGNRLLRWPARGYIYVFRGTPLLVQLFLIYYG 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242  82 MYTLEIVKGTeFLNAFFRSGLNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYRCIILPSALRIALP 161
Cdd:COG4160  76 LGQFEWVRES-WLWPLLRDPWFCALLALTLNTAAYTAEIFRGAIRAVPKGEIEAARALGMSRWQTFRRIILPSALRRALP 154

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16130242 162 AYSNEVILMLHSTALAFTATVPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKRWLQHVKPSS 236
Cdd:COG4160 155 AYSNEVILMLKATALASTITVMDLTGVARRIYSRTYDPFEPFLIAALIYLVITFLLTRLFRLLERRLLRHLRPRR 229
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 20-227 6.41e-26

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 100.31  E-value: 6.41e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242    20 FTGVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYSGMYTLEIVkgtefLNAFFR 99
Cdd:TIGR03003  14 IEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDIGIR-----LPALVA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242   100 SglnctVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYRCIILPSALRIALPAYSNEVILMLHSTALAFT 179
Cdd:TIGR03003  89 G-----VLGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSA 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 16130242   180 ATVPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKR 227
Cdd:TIGR03003 164 ITVLELMNQAKSIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEAR 211
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 25-218 2.01e-17

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 77.32  E-value: 2.01e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242  25 ITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYSGMytleivkGTEFLNAFFRSGLNC 104
Cdd:cd06261   3 NTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLF-------GVLLGWGILPGLGLP 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242 105 TVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYRCIILPSALRIALPAYSNEVILMLHSTALAFTATVPD 184
Cdd:cd06261  76 ALILALLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGE 155

                       170       180       190
                ....*....|....*....|....*....|....
gi 16130242 185 LLKIARDINAATYQPFTAFGIAAVLYLIISYVLI 218
Cdd:cd06261 156 APGPGTGLLLIFAILFPGDLGVAAAVALILLLLS 189
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 37-224 3.58e-07

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 48.83  E-value: 3.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242    37 GGVLALFLAIGRvssNKYIQFPIWLFTYIFRGTPLYVQLLVFYsgmytleivkgTEFLNAFFRSGLNCTVLALTLNTCAY 116
Cdd:pfam00528   1 GIPLGIIAALRR---GRRLDRLLRPLIDLLQALPSFVLAILLV-----------VIAILSILGHGILPAIILALLGWAGY 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242   117 TTEIFAGAIRSVPHGEIEAARAYGFSTFKMYRCIILPSALRIALPAYSNEVI-LMLHSTALAFTATVPDL-LKIARDINA 194
Cdd:pfam00528  67 ARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGgALGGAVLLEFLGSWPGLgLLLIEAILG 146

                         170       180       190
                  ....*....|....*....|....*....|
gi 16130242   195 ATYQPFTAFGIAAVLYLIISYVLISLFRRA 224
Cdd:pfam00528 147 YDYPEIQGPVLAAALILLLLNLLVDILQRL 176
 
Name Accession Description Interval E-value
PRK15069 PRK15069
histidine ABC transporter permease HisM;
1-234 9.18e-164

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 451.81  E-value: 9.18e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242    1 MIEILHEYWKPLLWTDGYRFTGVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYS 80
Cdd:PRK15069   1 MIEILQEYWKALLWTDGYRFTGLAITLWLLVASVVIGFVLAVPLAIARVSSNKWIRFPVWLYTYVFRGTPLYVQLLVFYT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242   81 GMYTLEIVKGTEFLNAFFRSGLNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYRCIILPSALRIAL 160
Cdd:PRK15069  81 GMYSLEIVRGTDLLDAFFRSGLNCTILAFTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRAL 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16130242  161 PAYSNEVILMLHSTALAFTATVPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKRWLQHVKP 234
Cdd:PRK15069 161 PAYSNEVILMLHATTLAFTATVPDILKIARDINSATYQPFQAFGIAAVLYLIISFVLISLFRRAERRWLAHLKP 234
ArtM COG4160
ABC-type arginine/histidine transport system, permease component [Amino acid transport and ...
 2-236 1.84e-107

ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443325 [Multi-domain]  Cd Length: 229  Bit Score: 308.95  E-value: 1.84e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242   2 IEILHEYWkPLLWTdgyrftGVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYSG 81
Cdd:COG4160   3 LDLLFEYL-PLLLS------GLPLTLQLLALSLLLGFLLAVPLALARASGNRLLRWPARGYIYVFRGTPLLVQLFLIYYG 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242  82 MYTLEIVKGTeFLNAFFRSGLNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYRCIILPSALRIALP 161
Cdd:COG4160  76 LGQFEWVRES-WLWPLLRDPWFCALLALTLNTAAYTAEIFRGAIRAVPKGEIEAARALGMSRWQTFRRIILPSALRRALP 154

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16130242 162 AYSNEVILMLHSTALAFTATVPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKRWLQHVKPSS 236
Cdd:COG4160 155 AYSNEVILMLKATALASTITVMDLTGVARRIYSRTYDPFEPFLIAALIYLVITFLLTRLFRLLERRLLRHLRPRR 229
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 2-228 2.56e-63

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 196.45  E-value: 2.56e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242   2 IEILHEYWKPLLwtdgyrfTGVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYSG 81
Cdd:COG0765   5 FSVLLDYLPLLL-------EGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242  82 MYTLEIVkgtefLNAFFRSglnctVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYRCIILPSALRIALP 161
Cdd:COG0765  78 LPLLGID-----LSPFVAA-----VIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILP 147

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16130242 162 AYSNEVILMLHSTALAFTATVPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKRW 228
Cdd:COG0765 148 PLGNEFISLLKDTSLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRL 214
artM PRK11122
arginine ABC transporter permease ArtM;
22-229 2.99e-42

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 142.79  E-value: 2.99e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242   22 GVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYSGMYTLEIVKGTEFLNAFFRSG 101
Cdd:PRK11122  11 GLHTSLTLTVASLLVALVLALIFTIILTLKTPVLVWLVRGYITLFTGTPLLVQIFLIYYGPGQFPWLQEYPWLWHLLSQP 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242  102 LNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYRcIILPSALRIALPAYSNEVILMLHSTALAFTAT 181
Cdd:PRK11122  91 WLCAMLALALNSAAYSTQLFYGAVRAIPEGQWQSCAALGMSKKQTLR-ILLPYAFKRALSSYSNEVVLVFKSTSLAYTIT 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 16130242  182 VPDLLKIARDINAATYQpFTAFGIAAVLYLIISYVLISLFRRAEKRWL 229
Cdd:PRK11122 170 LMDVMGYSQLLYGRTYD-VMVFGAAGIIYLVVNGLLTLLMRLIERKAL 216
PRK15100 PRK15100
cystine ABC transporter permease;
22-231 7.00e-31

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 113.31  E-value: 7.00e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242   22 GVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYSGMYTLeivkGTEFlnaffrSG 101
Cdd:PRK15100  18 GAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQF----GIEL------DP 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242  102 LNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYRCIILPSALRIALPAYSNEVILMLHSTALAFTAT 181
Cdd:PRK15100  88 IPAAMIGLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQ 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 16130242  182 VPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKRWLQH 231
Cdd:PRK15100 168 VPELFRQAQLITSRTLEVFTMYLAASLIYWIMATVLSALQNRFENQLNRQ 217
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
25-227 3.65e-30

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 112.08  E-value: 3.65e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242   25 ITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTP-----LYV-----QLLVFYSGMYTLEI----VKG 90
Cdd:PRK11123  13 MTVGLAVCALIVGLALAMLFAVWESAKWRPVAWPGTALVTLLRGLPeilvvLFIyfgssQLLLTLSDGFTLNLgfvqIPV 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242   91 TEFLNAFFRSGLNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYRCIILPSALRIALPAYSNEVILM 170
Cdd:PRK11123  93 QMDIENFEVSPFLCGVIALSLLYAAYASQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHALPGLGNQWLVL 172

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 16130242  171 LHSTALAFTATVPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKR 227
Cdd:PRK11123 173 LKDTALVSLISVNDLMLQTKSIATRTQEPFTWYIIAAAIYLVITLISQYILKRIELR 229
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 20-227 6.41e-26

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 100.31  E-value: 6.41e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242    20 FTGVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYSGMYTLEIVkgtefLNAFFR 99
Cdd:TIGR03003  14 IEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDIGIR-----LPALVA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242   100 SglnctVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYRCIILPSALRIALPAYSNEVILMLHSTALAFT 179
Cdd:TIGR03003  89 G-----VLGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSA 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 16130242   180 ATVPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKR 227
Cdd:TIGR03003 164 ITVLELMNQAKSIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEAR 211
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
20-233 4.27e-24

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 96.02  E-value: 4.27e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242   20 FTGVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTP-LYVQLLVFYSGMYTLEIVKGTEFLNAFF 98
Cdd:PRK15135  10 LQGALVTLELALSSVVLAVIIGLIGAGGKLSQNRLLGLIFEGYTTLIRGVPdLVLMLLIFYGLQIALNSVTEALGVGQID 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242   99 RSGLNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYRCIILPSALRIALPAYSNEVILMLHSTALAF 178
Cdd:PRK15135  90 IDPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKATALVS 169

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 16130242  179 TATVPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKRWLQHVK 233
Cdd:PRK15135 170 LLGLEDVVKATQLAGKSTWEPFYFAIVCGVIYLVFTTVSNGVLLWLERRYSVGVK 224
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 20-227 2.94e-20

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 85.49  E-value: 2.94e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242   20 FTGVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYSGMYTLeivkgtefLNAFFR 99
Cdd:PRK09494  16 LEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPMA--------FNDLRI 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242  100 SGLNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYRCIILPSALRIALPAYSNEVILMLHSTALAFT 179
Cdd:PRK09494  88 DPFTAAVVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTSLFIV 167

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 16130242  180 ATVPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKR 227
Cdd:PRK09494 168 IGVAELTRQGQEIIAGNFRALEIWSAVAVIYLIITLVLSFILRRLERR 215
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 25-218 2.01e-17

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 77.32  E-value: 2.01e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242  25 ITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYSGMytleivkGTEFLNAFFRSGLNC 104
Cdd:cd06261   3 NTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLF-------GVLLGWGILPGLGLP 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242 105 TVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYRCIILPSALRIALPAYSNEVILMLHSTALAFTATVPD 184
Cdd:cd06261  76 ALILALLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGE 155

                       170       180       190
                ....*....|....*....|....*....|....
gi 16130242 185 LLKIARDINAATYQPFTAFGIAAVLYLIISYVLI 218
Cdd:cd06261 156 APGPGTGLLLIFAILFPGDLGVAAAVALILLLLS 189
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 20-123 1.56e-12

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 61.78  E-value: 1.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242    20 FTGVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYSGMYTLEIVkgteflnaffR 99
Cdd:TIGR01726   6 LKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFGLPLIGIR----------L 75

                          90       100
                  ....*....|....*....|....
gi 16130242   100 SGLNCTVLALTLNTCAYTTEIFAG 123
Cdd:TIGR01726  76 SPLTAAVIALTLFYGAYLAEIFRG 99
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
18-227 2.21e-12

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 64.08  E-value: 2.21e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242   18 YRFTGVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYsgMYTLEIVKGTEFLNAF 97
Cdd:PRK15107  15 YLLDGLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIPLVMVLLWFY--LIVPGFLQNVLGLSPK 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242   98 FRSGLNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYRCIILPSALRIALPAYSNEVILMLHSTALA 177
Cdd:PRK15107  93 TDIRLISAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDTSLV 172

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 16130242  178 FTATVPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKR 227
Cdd:PRK15107 173 YVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKKR 222
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 37-224 3.58e-07

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 48.83  E-value: 3.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242    37 GGVLALFLAIGRvssNKYIQFPIWLFTYIFRGTPLYVQLLVFYsgmytleivkgTEFLNAFFRSGLNCTVLALTLNTCAY 116
Cdd:pfam00528   1 GIPLGIIAALRR---GRRLDRLLRPLIDLLQALPSFVLAILLV-----------VIAILSILGHGILPAIILALLGWAGY 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242   117 TTEIFAGAIRSVPHGEIEAARAYGFSTFKMYRCIILPSALRIALPAYSNEVI-LMLHSTALAFTATVPDL-LKIARDINA 194
Cdd:pfam00528  67 ARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGgALGGAVLLEFLGSWPGLgLLLIEAILG 146

                         170       180       190
                  ....*....|....*....|....*....|
gi 16130242   195 ATYQPFTAFGIAAVLYLIISYVLISLFRRA 224
Cdd:pfam00528 147 YDYPEIQGPVLAAALILLLLNLLVDILQRL 176
PhnE TIGR01097
phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound ...
 1-156 1.40e-05

phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound analogous to organic phosphates, but in which the C-O-P linkage is replaced by a direct, stable C-P bond. Some bacteria can utilize phosphonates as a source of phosphorus. This family consists of permease proteins of known or predicted phosphonate ABC transporters. Often this protein is found as a duplicated pair, occasionally as a fused pair. Certain "second" copies score in between the trusted and noise cutoff and should be considered true hits (by context). [Transport and binding proteins, Anions]


Pssm-ID: 273441 [Multi-domain]  Cd Length: 250  Bit Score: 44.84  E-value: 1.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242     1 MIEILHEYWKPLLWTDGYRFTGVAITLWLLILSVVIGGVLALFLAI---GRVSSNKYIQFPIWLFTYIFRGTPlyvqllv 77
Cdd:TIGR01097  38 MADLLGRMFPPDWSYLPRILKALLETLAMAILGTVLAAVLAVPLALlaaRNITPSPWLYGLARLLLNFLRAIP------- 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242    78 fysgmytlEIVKGTEFLNAFfrsGLN--CTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYRCIILPSA 155
Cdd:TIGR01097 111 --------ELVWALIFVAAV---GLGpfAGVLALAFHTVGFLGKLFAEAIEEVDPGPVEALRATGASKLQVIRYGVLPQV 179


                  .
gi 16130242   156 L 156
Cdd:TIGR01097 180 L 180
PhnE COG3639
ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport ...
 1-156 5.02e-05

ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 442856 [Multi-domain]  Cd Length: 244  Bit Score: 43.15  E-value: 5.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242   1 MIEILHEYWKPLLWTDGYRFTGVAITLWLLILSVVIGGVLALFLAI---GRVSSNKYIQFPIWLFTYIFRGTPlyvqllv 77
Cdd:COG3639  31 LADFLSRFFPPDWSYLPDLLSALLETLAIALLGTLLGAVLALPLAFlaaRNLAPNPWVRLLARRLLNVLRAIP------- 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242  78 fysgmytlEIVKGTEFLNAFfrsGLNCT--VLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYRCIILPSA 155
Cdd:COG3639 104 --------ELVWALIFVAAV---GLGPFagVLALAIHTIGFLGKLFAEAIEEIDPGPVEALRATGASRLQVIRYGVLPQV 172


                .
gi 16130242 156 L 156
Cdd:COG3639 173 L 173
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 13-156 2.62e-04

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 40.90  E-value: 2.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130242  13 LWTDGYRFTGVAITLWLLILSVVIGGVLALFLAIGrVSSNKYIQFPIWLFTYIFRGTPL--YVQLLVFYSGMYTLEIVkG 90
Cdd:COG0600  53 LLASGELWEHLLASLLRVLLGFALAALLGVPLGLL-LGLSRLLRRLLDPLLVFLRPIPPlaLAPLLILWFGIGEASKI-F 130

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16130242  91 TEFLNAFFrsglnctvlALTLNTcaytteifAGAIRSVPHGEIEAARAYGFSTFKMYRCIILPSAL 156
Cdd:COG0600 131 VIFLGAFF---------PILLNT--------AAGVRSVDPELLELARSLGASRWQILRKVVLPAAL 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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