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Conserved domains on  [gi|16131610|ref|NP_418198|]
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flavoprotein MioC [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

FMN-binding protein MioC( domain architecture ID 10013133)

FMN-binding flavoprotein MioC is involved in cofactor binding and electron transfer in biotin biosynthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK09004 PRK09004
FMN-binding protein MioC; Provisional
 1-146 1.67e-96

FMN-binding protein MioC; Provisional


:

Pssm-ID: 181608 [Multi-domain]  Cd Length: 146  Bit Score: 274.40  E-value: 1.67e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131610    1 MADITLISGSTLGGAEYVAEHLAEKLEEAGFTTETLHGPLLEDLPASGIWLVISSTHGAGDIPDNLSPFYEALQEQKPDL 80
Cdd:PRK09004   1 MADITLISGSTLGGAEYVADHLAEKLEEAGFSTETLHGPLLDDLSASGLWLIVTSTHGAGDLPDNLQPFFEELQEQKPDL 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16131610   81 SAVRFGAIGIGSREYDTFCGAIDKLEAELKNSGAKQTGETLKINILDHDIPEDPAEEWLGSWVNLL 146
Cdd:PRK09004  81 SQVRFAAIGIGSSEYDTFCGAIDKLEQLLKAKGAKQIGETLKIDVLQHPIPEDPAEEWLKSWINLL 146
 
Name Accession Description Interval E-value
PRK09004 PRK09004
FMN-binding protein MioC; Provisional
 1-146 1.67e-96

FMN-binding protein MioC; Provisional


Pssm-ID: 181608 [Multi-domain]  Cd Length: 146  Bit Score: 274.40  E-value: 1.67e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131610    1 MADITLISGSTLGGAEYVAEHLAEKLEEAGFTTETLHGPLLEDLPASGIWLVISSTHGAGDIPDNLSPFYEALQEQKPDL 80
Cdd:PRK09004   1 MADITLISGSTLGGAEYVADHLAEKLEEAGFSTETLHGPLLDDLSASGLWLIVTSTHGAGDLPDNLQPFFEELQEQKPDL 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16131610   81 SAVRFGAIGIGSREYDTFCGAIDKLEAELKNSGAKQTGETLKINILDHDIPEDPAEEWLGSWVNLL 146
Cdd:PRK09004  81 SQVRFAAIGIGSSEYDTFCGAIDKLEQLLKAKGAKQIGETLKIDVLQHPIPEDPAEEWLKSWINLL 146
Flavodoxin_1 pfam00258
Flavodoxin;
6-138 1.03e-28

Flavodoxin;


Pssm-ID: 425562 [Multi-domain]  Cd Length: 142  Bit Score: 102.45  E-value: 1.03e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131610     6 LISGSTLGGAEYVAEHLAEKLEEAGFTTETLHGPLLE----DLPASGIWLVISSTHGAGDIPDNLSPFYEALQEQK---- 77
Cdd:pfam00258   1 IFYGSQTGNTEKLAEAIAEGLGEAGFEVDVVDLDDVDetlsEIEEEDLLLVVVSTWGEGEPPDNAKPFVDWLLLFGtled 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16131610    78 PDLSAVRFGAIGIGSREYDTFCGAIDKLEAELKNSGAKQTGETLKINILD-HDIPEDPAEEW 138
Cdd:pfam00258  81 GDLSGLKYAVFGLGDSGYEGFCGAAKKLDEKLSELGASRVGPLGEGDEDPqEDGLEEAFEAW 142
CysJ COG0369
Flavoprotein (flavin reductase) subunit CysJ of sulfite and N-hydroxylaminopurine reductases ...
 4-147 1.34e-25

Flavoprotein (flavin reductase) subunit CysJ of sulfite and N-hydroxylaminopurine reductases [Nucleotide transport and metabolism, Inorganic ion transport and metabolism]; Flavoprotein (flavin reductase) subunit CysJ of sulfite and N-hydroxylaminopurine reductases is part of the Pathway/BioSystem: Cysteine biosynthesis


Pssm-ID: 440138 [Multi-domain]  Cd Length: 561  Bit Score: 100.99  E-value: 1.34e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131610   4 ITLISGSTLGGAEYVAEHLAEKLEEAGFTTETLhgPL----LEDLPASGIWLVISSTHGAGDIPDNLSPFYEALQEQK-P 78
Cdd:COG0369  29 LTILYGSQTGNAEGLAEQLAERAKAAGLAVTLA--SLddykPKDLAKEGLLLIVTSTYGEGEPPDNARAFYEFLHSKKaP 106

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16131610  79 DLSAVRFGAIGIGSREYDTFCGA---IDKLEAELknsGAKQTGETLKiniLDHDIpEDPAEEWLGSWVNLLK 147
Cdd:COG0369 107 KLDGLRYAVLGLGDSSYETFCQTgkdFDARLEEL---GATRLLPRVD---CDVDY-EEAAEAWLAAVLAALA 171
 
Name Accession Description Interval E-value
PRK09004 PRK09004
FMN-binding protein MioC; Provisional
 1-146 1.67e-96

FMN-binding protein MioC; Provisional


Pssm-ID: 181608 [Multi-domain]  Cd Length: 146  Bit Score: 274.40  E-value: 1.67e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131610    1 MADITLISGSTLGGAEYVAEHLAEKLEEAGFTTETLHGPLLEDLPASGIWLVISSTHGAGDIPDNLSPFYEALQEQKPDL 80
Cdd:PRK09004   1 MADITLISGSTLGGAEYVADHLAEKLEEAGFSTETLHGPLLDDLSASGLWLIVTSTHGAGDLPDNLQPFFEELQEQKPDL 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16131610   81 SAVRFGAIGIGSREYDTFCGAIDKLEAELKNSGAKQTGETLKINILDHDIPEDPAEEWLGSWVNLL 146
Cdd:PRK09004  81 SQVRFAAIGIGSSEYDTFCGAIDKLEQLLKAKGAKQIGETLKIDVLQHPIPEDPAEEWLKSWINLL 146
PRK08105 PRK08105
flavodoxin; Provisional
 1-147 4.74e-37

flavodoxin; Provisional


Pssm-ID: 181230 [Multi-domain]  Cd Length: 149  Bit Score: 123.84  E-value: 4.74e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131610    1 MADITLISGSTLGGAEYVAEHLAEKLEEAGFTTETLHGPLLEDL--PASGIWLVISSTHGAGDIPDNLSPFYEALQEQKP 78
Cdd:PRK08105   1 MAKVGIFVGTVYGNALLVAEEAEAILTAQGHEVTLFEDPELSDWqpYQDELVLVVTSTTGQGDLPDSIVPLFQALKDTAG 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16131610   79 DLSAVRFGAIGIGSREYDTFCGAIDKLEAELKNSGAKQTGETLKINILDHDIPEDPAEEWLGSWVNLLK 147
Cdd:PRK08105  81 YQPNLRYGVIALGDSSYDNFCGAGKQFDALLQEQGAKRVGERLEIDACETPEPEVEANPWVEQWGTLLS 149
Flavodoxin_1 pfam00258
Flavodoxin;
6-138 1.03e-28

Flavodoxin;


Pssm-ID: 425562 [Multi-domain]  Cd Length: 142  Bit Score: 102.45  E-value: 1.03e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131610     6 LISGSTLGGAEYVAEHLAEKLEEAGFTTETLHGPLLE----DLPASGIWLVISSTHGAGDIPDNLSPFYEALQEQK---- 77
Cdd:pfam00258   1 IFYGSQTGNTEKLAEAIAEGLGEAGFEVDVVDLDDVDetlsEIEEEDLLLVVVSTWGEGEPPDNAKPFVDWLLLFGtled 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16131610    78 PDLSAVRFGAIGIGSREYDTFCGAIDKLEAELKNSGAKQTGETLKINILD-HDIPEDPAEEW 138
Cdd:pfam00258  81 GDLSGLKYAVFGLGDSGYEGFCGAAKKLDEKLSELGASRVGPLGEGDEDPqEDGLEEAFEAW 142
CysJ COG0369
Flavoprotein (flavin reductase) subunit CysJ of sulfite and N-hydroxylaminopurine reductases ...
 4-147 1.34e-25

Flavoprotein (flavin reductase) subunit CysJ of sulfite and N-hydroxylaminopurine reductases [Nucleotide transport and metabolism, Inorganic ion transport and metabolism]; Flavoprotein (flavin reductase) subunit CysJ of sulfite and N-hydroxylaminopurine reductases is part of the Pathway/BioSystem: Cysteine biosynthesis


Pssm-ID: 440138 [Multi-domain]  Cd Length: 561  Bit Score: 100.99  E-value: 1.34e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131610   4 ITLISGSTLGGAEYVAEHLAEKLEEAGFTTETLhgPL----LEDLPASGIWLVISSTHGAGDIPDNLSPFYEALQEQK-P 78
Cdd:COG0369  29 LTILYGSQTGNAEGLAEQLAERAKAAGLAVTLA--SLddykPKDLAKEGLLLIVTSTYGEGEPPDNARAFYEFLHSKKaP 106

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16131610  79 DLSAVRFGAIGIGSREYDTFCGA---IDKLEAELknsGAKQTGETLKiniLDHDIpEDPAEEWLGSWVNLLK 147
Cdd:COG0369 107 KLDGLRYAVLGLGDSSYETFCQTgkdFDARLEEL---GATRLLPRVD---CDVDY-EEAAEAWLAAVLAALA 171
FldA COG0716
Flavodoxin [Energy production and conversion]; Flavodoxin is part of the Pathway/BioSystem: ...
 4-142 1.39e-23

Flavodoxin [Energy production and conversion]; Flavodoxin is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440480 [Multi-domain]  Cd Length: 135  Bit Score: 89.19  E-value: 1.39e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131610   4 ITLISGSTLGGAEYVAEHLAEKLEEAGFTTETLHGPLLEDLPASGIWLVISSTHgAGDIPDNLSPFYEALQEqkpDLSAV 83
Cdd:COG0716   1 ILIVYGSTTGNTEKVAEAIAEALGAAGVDLFEIEDADLDDLEDYDLLILGTPTW-AGELPDDWEDFLEELKE---DLSGK 76

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16131610  84 RFGAIGIG-SREYDTfcgAIDKLEAELKNSGAKQTGE-TLKINILDH-DIPEDPAEEWLGSW 142
Cdd:COG0716  77 KVALFGTGdSSGYGD---ALGELKELLEEKGAKVVGGyDFEGSKAPDaEDTEERAEEWLKQL 135
PRK05723 PRK05723
flavodoxin; Provisional
 4-147 2.33e-20

flavodoxin; Provisional


Pssm-ID: 168208  Cd Length: 151  Bit Score: 81.38  E-value: 2.33e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131610    4 ITLISGSTLGGAEYVAEHLAEKLEEAGFttETLHGP--LLEDLPASG--IWLVISSTHGAGDIPDNLSPFYEALQEQKPD 79
Cdd:PRK05723   3 VAILSGSVYGTAEEVARHAESLLKAAGF--EAWHNPraSLQDLQAFApeALLAVTSTTGMGELPDNLMPLYSAIRDQLPA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16131610   80 -LSAVRFGAIGIGSREY-DTFCGA---IDKLEAELknsGAKQTGETLKINILDHDIPEDPAEEWLGSWVNLLK 147
Cdd:PRK05723  81 aWRGLPGAVIALGDSSYgDTFCGGgeqMRELFAEL---GVREVQPMLRLDASETVTPETDAEPWLAEFAAALK 150
PRK07308 PRK07308
flavodoxin; Validated
 1-130 1.31e-17

flavodoxin; Validated


Pssm-ID: 180922 [Multi-domain]  Cd Length: 146  Bit Score: 74.06  E-value: 1.31e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131610    1 MADITLISGSTLGGAEYVAEHLAEKLEEAGFTTETLHGPLL--EDLPASGIWLVISSTHGAGDIPDNLSPFYEALQEQkp 78
Cdd:PRK07308   1 MALAKIVYASMTGNTEEIADIVADKLRELGHDVDVDECTTVdaSDFEDADIAIVATYTYGDGELPDEIVDFYEDLADL-- 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 16131610   79 DLSAVRFGAIGIGSREYDTFCGAIDKLEAELKNSGAKQTGETLKINIL--DHDI 130
Cdd:PRK07308  79 DLSGKIYGVVGSGDTFYDYFCKSVDDFEAQFALTGATKGAESVKVDLAaeDEDI 132
PRK06703 PRK06703
flavodoxin; Provisional
 1-133 3.75e-10

flavodoxin; Provisional


Pssm-ID: 235854 [Multi-domain]  Cd Length: 151  Bit Score: 54.76  E-value: 3.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131610    1 MADITLISGSTLGGAEYVAEHLAEKLEEAGFTTETLH--GPLLEDLPASGIWLVISSTHGAGDIPDNLSPFYEALQEQkp 78
Cdd:PRK06703   1 MAKILIAYASMSGNTEDIADLIKVSLDAFDHEVVLQEmdGMDAEELLAYDGIILGSYTWGDGDLPYEAEDFHEDLENI-- 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 16131610   79 DLSAVRFGAIGIGSREYDTFCGAIDKLEAELKNSGAKQTGETLKINiLDHDIPED 133
Cdd:PRK06703  79 DLSGKKVAVFGSGDTAYPLFCEAVTIFEERLVERGAELVQEGLKIE-LAPETDED 132
cysJ PRK10953
NADPH-dependent assimilatory sulfite reductase flavoprotein subunit;
1-147 7.75e-08

NADPH-dependent assimilatory sulfite reductase flavoprotein subunit;


Pssm-ID: 182862 [Multi-domain]  Cd Length: 600  Bit Score: 50.10  E-value: 7.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131610    1 MADITLISGSTLGGAEYVAEHLAEKLEEAGFTTETLHGP--LLEDLPASGIWLVISSTHGAGDIPDNLSPFYEALQEQK- 77
Cdd:PRK10953  61 MPGITLISASQTGNARRVAEQLRDDLLAAKLNVNLVNAGdyKFKQIAQEKLLIVVTSTQGEGEPPEEAVALHKFLFSKKa 140

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16131610   78 PDLSAVRFGAIGIGSREYDTFCGAIDKLEAELKNSGAKQTGETlkiniLDHDIP-EDPAEEWLGSWVNLLK 147
Cdd:PRK10953 141 PKLENTAFAVFGLGDTSYEFFCQAGKDFDSKLAELGAERLLDR-----VDADVEyQAAASEWRARVVDALK 206
PRK09267 PRK09267
flavodoxin FldA; Validated
 1-120 5.13e-07

flavodoxin FldA; Validated


Pssm-ID: 236439 [Multi-domain]  Cd Length: 169  Bit Score: 46.36  E-value: 5.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131610    1 MADITLISGSTLGGAEYVAEHLAEKLEEAGFTTETLHGPLLEDLPASGIWLVISSTHGAGDIPDNLSPFYEALQEqkPDL 80
Cdd:PRK09267   1 MAKIGIFFGSDTGNTEDIAKMIQKKLGKDVADVVDIAKASKEDFEAYDLLILGIPTWGYGELQCDWDDFLPELEE--IDF 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 16131610   81 SAVRFGAIGIGSRE-Y-DTFCGAIDKLEAELKNSGAKQTGET 120
Cdd:PRK09267  79 SGKKVALFGLGDQEdYaEYFCDAMGTLYDIVEPRGATIVGHW 120
PRK06756 PRK06756
flavodoxin; Provisional
 1-125 5.49e-07

flavodoxin; Provisional


Pssm-ID: 168663 [Multi-domain]  Cd Length: 148  Bit Score: 46.03  E-value: 5.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131610    1 MADITLISGSTLGGAEYVAEHLAEKLEEAGF---TTETLHGPLLEDLPASGIWLVISSTHGAGDIPDNLSPFYEALqeQK 77
Cdd:PRK06756   1 MSKLVMIFASMSGNTEEMADHIAGVIRETENeieVIDIMDSPEASILEQYDGIILGAYTWGDGDLPDDFLDFYDAM--DS 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 16131610   78 PDLSAVRFGAIGIGSREYDTFCGAIDKLEAELKNSGAKQTGETLKINI 125
Cdd:PRK06756  79 IDLTGKKAAVFGSCDSAYPKYGVAVDILIEKLQERGAAVVLEGLKVEL 126
NorV COG0426
Flavorubredoxin [Energy production and conversion];
4-124 6.77e-05

Flavorubredoxin [Energy production and conversion];


Pssm-ID: 440195 [Multi-domain]  Cd Length: 390  Bit Score: 41.36  E-value: 6.77e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131610   4 ITLISGSTLGGAEYVAEHLAEKLEEAGFTTE------TLHGPLLEDLPASGIWLVISSTHGAGDIPdnlsPFYEALQEQK 77
Cdd:COG0426 249 VVIVYASMYGNTEKMAEAIAEGLTEEGVKVKlydlekTDPSEIITEIFDAKGIVIGSPTYNGGAFP----PIADLLGYLK 324

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 16131610  78 PDLSAVRFGAIgIGSreYDTFCGAIDKLEAELKNSGAKQTGETLKIN 124
Cdd:COG0426 325 GLAPKNKLAGA-FGS--YGWSGEAVKLLEEKLEDAGFEVVFEPLRVK 368
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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