|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
7-361 |
0e+00 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 635.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 7 PISLRQRLILTIGAILLVFELISVFWLWHESTEQIQLFEQALRDNRNNDRHIMREIREAVASLIVPGVFMVSLTLFICYQ 86
Cdd:PRK10755 1 MISLRRRLLLTIGLILLVFQLISVFWLWHESTEQIQLLVQATLSARNNDEHVMKEIREAVASLLVPSLVMVSLTLLICFQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 87 AVRRITRPLAELQKELEARTADNLTPIAIHSATLEIEAVVSALNDLVSRLTSTLDNERLFTADVAHELRTPLAGVRLHLE 166
Cdd:PRK10755 81 AVRWITRPLAELQKELEARTADNLTPIAIHSSTLEIEAVTSALNQLVSRLTSTLDQERLFTADVAHELRTPLAGIRLHLE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 167 LLAKTHHIDVAPLVARLDQMMESVSQLLQLARAGQSFSSGNYQHVKLLEDVILPSYDELSTMLDQRQQTLLLPESAADIT 246
Cdd:PRK10755 161 LLEKQHHIDVAPLIARLDQMMHTVEQLLQLARAGQSFSSGHYQTVKLLEDVILPSQDELSEMLEQRQQTLLLPESAADIT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 247 VQGDATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDD-GAVMAVEDEGPGIDESKCGELSKAFVRMDSRYGGIGLGLSIV 325
Cdd:PRK10755 241 VQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDgGAVLAVEDEGPGIDESKCGELSKAFVRMDSRYGGIGLGLSIV 320
|
330 340 350
....*....|....*....|....*....|....*.
gi 16131938 326 SRITQLHHGQFFLQNRQETSGTRAWVRLKKDQYVAN 361
Cdd:PRK10755 321 SRITQLHHGQFFLQNRQERSGTRAWVWLPKAQNVAN 356
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
241-353 |
1.82e-55 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 177.21 E-value: 1.82e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 241 SAADITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDDGAVMAVEDEGPGIDESKCGELSKAFVRMDSR-YGGIG 319
Cdd:cd16940 1 SAADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAVIRVEDNGPGIDEEELEALFERFYRSDGQnYGGSG 80
|
90 100 110
....*....|....*....|....*....|....
gi 16131938 320 LGLSIVSRITQLHHGQFFLQNRQeTSGTRAWVRL 353
Cdd:cd16940 81 LGLSIVKRIVELHGGQIFLGNAQ-GGGLEAWVRL 113
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
3-357 |
1.14e-43 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 155.48 E-value: 1.14e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 3 FLRRPISLRQRLILTIGAILLVFELISVFWLWHESTEQIQLFEQALRDNRNNDRHIMREIREAVASLIVPGVFMVSLTLF 82
Cdd:COG5002 25 LLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLIL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 83 ICYQAVRRITRPLAELQKELEARTADNLTPIAIHSATLEIEAVVSALNDLVSRLTSTLDNERLFTADVAHELRTPLAGVR 162
Cdd:COG5002 105 LLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIR 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 163 LHLELLAKTHHIDVAPLVARLDQMMES-------VSQLLQLARAGQSFSSGNYQHV---KLLEDVIlpsyDELSTMLDQR 232
Cdd:COG5002 185 GYLELLLDGAADDPEERREYLEIILEEaerlsrlVNDLLDLSRLESGELKLEKEPVdlaELLEEVV----EELRPLAEEK 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 233 QQTLLLPESAADITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKL-QEDDGAVMAVEDEGPGIDESKCGELSKAFVRM 311
Cdd:COG5002 261 GIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLrEEDDQVRISVRDTGIGIPEEDLPRIFERFYRV 340
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 16131938 312 DS----RYGGIGLGLSIVSRITQLHHGQFFLQNRQEtSGTRAWVRLKKDQ 357
Cdd:COG5002 341 DKsrsrETGGTGLGLAIVKHIVEAHGGRIWVESEPG-KGTTFTITLPLAR 389
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
41-353 |
1.27e-43 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 153.53 E-value: 1.27e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 41 IQLFEQALRDNRNNDRHIMREIREAVASLIVPGVFMVSLTLFICYQAVRRITRPLAELQKELEARTADNLTPIAIHSATL 120
Cdd:COG0642 8 LVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 121 EIEAVVSALNDLVSRLTSTLDNERLFTADVAHELRTPLAGVRLHLELLAKTHHIDVAPLVARL----DQMMESVSQLLQL 196
Cdd:COG0642 88 LLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREYLETIlrsaDRLLRLINDLLDL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 197 ARAGQSFSSGNYQHV---KLLEDVIlpsyDELSTMLDQRQQTLLLPESAADITVQGDATLLRMLLRNLVENAHRYSPQGS 273
Cdd:COG0642 168 SRLEAGKLELEPEPVdlaELLEEVV----ELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 274 NIMIKLQEDDGAVM-AVEDEGPGIDESKCGELSKAFVRMDS--RYGGIGLGLSIVSRITQLHHGQFFLQNRQETsGTRAW 350
Cdd:COG0642 244 TVTVSVRREGDRVRiSVEDTGPGIPPEDLERIFEPFFRTDPsrRGGGTGLGLAIVKRIVELHGGTIEVESEPGK-GTTFT 322
|
...
gi 16131938 351 VRL 353
Cdd:COG0642 323 VTL 325
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
146-353 |
8.54e-42 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 146.21 E-value: 8.54e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 146 FTADVAHELRTPLAGVRLHLELLAKTHHIDVAPLVARLDQMMES-------VSQLLQLARAGQSFSSGNYQHVKLlEDVI 218
Cdd:COG2205 19 FLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESaerllrlIEDLLDLSRLESGKLSLELEPVDL-AELL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 219 LPSYDELSTMLDQRQQTLLLPESAADITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKL-QEDDGAVMAVEDEGPGID 297
Cdd:COG2205 98 EEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISArREGDGVRISVSDNGPGIP 177
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 16131938 298 ESKCGELSKAFVRMDS--RYGGIGLGLSIVSRITQLHHGQFFLQNRqETSGTRAWVRL 353
Cdd:COG2205 178 EEELERIFERFYRGDNsrGEGGTGLGLAIVKRIVEAHGGTIWVESE-PGGGTTFTVTL 234
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
66-343 |
6.36e-36 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 135.55 E-value: 6.36e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 66 VASLIVPGVFMVSLTLFICYQAVRRITRPLAELQKELEARTADNLTPIAIHSATLEIEAVVSALNDLVSRLTSTLDNERL 145
Cdd:PRK10337 160 VAGQLIPWLVALPIMLIILMVLLGRELAPLKKLALALRMRDPDSETPLNATGVPSEVRPLVEALNQLFARTHAMMVRERR 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 146 FTADVAHELRTPLAGVRLHLElLAKTHHID-------VAPLVARLDQMMESVSQLLQLARAgQSFSSgnyqhvklLEDVI 218
Cdd:PRK10337 240 FTSDAAHELRSPLAALKVQTE-VAQLSDDDpqarkkaLLQLHAGIDRATRLVDQLLTLSRL-DSLDN--------LQDVA 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 219 LPSYDEL--STMLDQ---RQQ---TLLLPESAADITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDDgavMAVE 290
Cdd:PRK10337 310 EIPLEDLlqSAVMDIyhtAQQagiDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARN---FTVR 386
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 16131938 291 DEGPGIDESKCGELSKAFVRMDSR-YGGIGLGLSIVSRITQLHHGQFFLQNRQE 343
Cdd:PRK10337 387 DNGPGVTPEALARIGERFYRPPGQeATGSGLGLSIVRRIAKLHGMNVSFGNAPE 440
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
82-335 |
1.44e-27 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 110.76 E-value: 1.44e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 82 FICYQAVRRITRPLaelqkELEARTADNLTpIAIHSATLEIEAVVSALNDlVSRLTSTLDNERLFTADVAHELRTPLAGV 161
Cdd:TIGR02966 60 FVEYLAAGRFSEPL-----ELPSPINSERV-LEIRIAPYGEEQKLLVARD-VTRLRRLEQMRRDFVANVSHELRTPLTVL 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 162 RLHLELLAKTHHIDvaPLVAR--LDQM------MES-VSQLLQLARAGQSFSSGNYQHVKLLEdVILPSYDELSTMLDQR 232
Cdd:TIGR02966 133 RGYLETLADGPDED--PEEWNraLEIMleqsqrMQSlVEDLLTLSRLESAASPLEDEPVDMPA-LLDHLRDEAEALSQGK 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 233 QQTLLLpESAADITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDD-GAVMAVEDEGPGIDESKCGELSKAFVRM 311
Cdd:TIGR02966 210 NHQITF-EIDGGVDVLGDEDELRSAFSNLVSNAIKYTPEGGTITVRWRRDGgGAEFSVTDTGIGIAPEHLPRLTERFYRV 288
|
250 260
....*....|....*....|....*...
gi 16131938 312 D---SR-YGGIGLGLSIVSRITQLHHGQ 335
Cdd:TIGR02966 289 DksrSRdTGGTGLGLAIVKHVLSRHHAR 316
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
88-353 |
2.23e-25 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 106.15 E-value: 2.23e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 88 VRRITRPLAELQKELEARTADNLTPIAIHSATLEIEAVVSALNDLvSRLTSTLDNER-LFTADVAHELRTPLAGVRLHLE 166
Cdd:PRK09467 174 IRIQNRPLVALEHAALQVGKGEIPPPLREYGASEVRSVTRAFNQM-AAGIKQLEDDRtLLMAGVSHDLRTPLTRIRLATE 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 167 LLAKTHHIDVAPLVARLDQMMESVSQLLQLARAGQSFSSGNYQHVKLLEDVILpsydelSTMLDQRQQTLLLPESAADIT 246
Cdd:PRK09467 253 MMSEEDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNALLGEVIA------AESGYEREIETALQPGPIEVP 326
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 247 VQGDAtlLRMLLRNLVENAHRYSpqgsNIMIKL---QEDDGAVMAVEDEGPGIDESKCGELSKAFVRMDSRYG--GIGLG 321
Cdd:PRK09467 327 MNPIA--IKRALANLVVNAARYG----NGWIKVssgTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARGssGTGLG 400
|
250 260 270
....*....|....*....|....*....|..
gi 16131938 322 LSIVSRITQLHHGQFFLQNRQEtSGTRAWVRL 353
Cdd:PRK09467 401 LAIVKRIVDQHNGKVELGNSEE-GGLSARAWL 431
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
249-357 |
4.95e-25 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 97.82 E-value: 4.95e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 249 GDATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDDGAVMAVEDEGPGIDESKCGELSKAFVRMDSR-YGGIGLGLSIVSR 327
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRgGGGTGLGLSIVRK 80
|
90 100 110
....*....|....*....|....*....|
gi 16131938 328 ITQLHHGQFFLQNRqETSGTRAWVRLKKDQ 357
Cdd:pfam02518 81 LVELLGGTITVESE-PGGGTTVTLTLPLAQ 109
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
81-353 |
1.13e-24 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 103.89 E-value: 1.13e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 81 LFICYQAVRRITRPLAELQKELEARTADNLTPIAIHSATLEIEAVVSALNDLvsrlTSTLDNERL-----FTADVAHELR 155
Cdd:COG5000 138 LLPELDLAELLREALERGWQEEIELTRDGRRTLLVRASPLRDDGYVIVFDDI----TELLRAERLaawgeLARRIAHEIK 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 156 TPLAGVRLHLELLAKTHHIDVAP-----------LVARLDQMMESVSQLLQLARAGQSfssgNYQHV---KLLEDVIlps 221
Cdd:COG5000 214 NPLTPIQLSAERLRRKLADKLEEdredleraldtIIRQVDRLKRIVDEFLDFARLPEP----QLEPVdlnELLREVL--- 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 222 yDELSTMLDQRQQTLLLPESAADITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKL-QEDDGAVMAVEDEGPGIDESk 300
Cdd:COG5000 287 -ALYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTrREDGRVRIEVSDNGPGIPEE- 364
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 16131938 301 cgELSKAFVR-MDSRYGGIGLGLSIVSRITQLHHGQFFLQNRQETsGTRAWVRL 353
Cdd:COG5000 365 --VLERIFEPfFTTKPKGTGLGLAIVKKIVEEHGGTIELESRPGG-GTTFTIRL 415
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
52-334 |
2.23e-23 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 100.54 E-value: 2.23e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 52 RNNDRHIMREIREAvasLIVPGVFMVSLTLFICYQAVRRITRPLAELQKELEARTADNL-TPIAIHSATLEIEAVVSALN 130
Cdd:TIGR01386 152 INAHTHLLDALRKW---LILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLdQRLDPSRAPAELRELAQSFN 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 131 DLVSRLTSTLDNERLFTADVAHELRTPLAGVRLHLElLAKTHHIDVAPLVA----------RLDQMmesVSQLLQLARAG 200
Cdd:TIGR01386 229 AMLGRLEDAFQRLSQFSADLAHELRTPLTNLLGQTQ-VALSQPRTGEEYREvlesnleeleRLSRM---VSDMLFLARAD 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 201 QSFSSGNYQHVKL---LEDVIlpsyDELSTMLDQRQQTLLLPESAadiTVQGDATLLRMLLRNLVENAHRYSPQGSNIMI 277
Cdd:TIGR01386 305 NGQLALERVRLDLaaeLAKVA----EYFEPLAEERGVRIRVEGEG---LVRGDPQMFRRAISNLLSNALRHTPDGGTITV 377
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16131938 278 KLQEDDGAV-MAVEDEGPGIDESKCGELSKAFVRMD-SRYG---GIGLGLSIVSRITQLHHG 334
Cdd:TIGR01386 378 RIERRSDEVrVSVSNPGPGIPPEHLSRLFDRFYRVDpARSNsgeGTGLGLAIVRSIMEAHGG 439
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
151-356 |
6.57e-23 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 99.53 E-value: 6.57e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 151 AHELRTPLAGVRLHLELLAK----------THHIDVAPlvARLDQMMEsvsQLLQLARAGQSfssgnyQHVKLLEDVILP 220
Cdd:PRK11100 264 THELKSPLAAIRGAAELLQEdpppedrarfTGNILTQS--ARLQQLID---RLLELARLEQR------QELEVLEPVALA 332
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 221 S-YDELSTMLDQR--QQTLLLPESAADITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDDGAV-MAVEDEGPGI 296
Cdd:PRK11100 333 AlLEELVEAREAQaaAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVaLSVEDQGPGI 412
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16131938 297 DESKCGELSKAF---VRMDSRYGGIGLGLSIVSRITQLHHGQFFLQNRQEtSGTRAWVRLKKD 356
Cdd:PRK11100 413 PDYALPRIFERFyslPRPANGRKSTGLGLAFVREVARLHGGEVTLRNRPE-GGVLATLTLPRH 474
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
249-355 |
1.10e-22 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 91.56 E-value: 1.10e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 249 GDATLLRMLLRNLVENAHRYSPQGSNIMIKL-QEDDGAVMAVEDEGPGIDESKCGELSKAFVRMD---SRYGGIGLGLSI 324
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLeRDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDkrsRKIGGTGLGLSI 80
|
90 100 110
....*....|....*....|....*....|.
gi 16131938 325 VSRITQLHHGQFFLQNRqETSGTRAWVRLKK 355
Cdd:smart00387 81 VKKLVELHGGEISVESE-PGGGTTFTITLPL 110
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
3-335 |
7.01e-22 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 96.78 E-value: 7.01e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 3 FLRRPISLRQRLILTIGAILLVFELISVFWLWHESTEQIQLFEQALRDNRNNDRHIMREIREAVASLIVPGVFMVSLTLF 82
Cdd:COG4251 142 LLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSL 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 83 ICYQAVRRITRPLAELQKELEARTADNLTPIAIHSATLEIEAVVSALNDLVSRLTSTldNERL--FTADVAHELRTPLAG 160
Cdd:COG4251 222 GGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERS--NEELeqFAYVASHDLREPLRK 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 161 VRLHLELLAKTH----------HIDVAplVARLDQMMESVSQLLQLARAGQSfsSGNYQHV---KLLEDVIlpsyDELST 227
Cdd:COG4251 300 ISGFSQLLEEDYgdkldeegreYLERI--RDAAERMQALIDDLLAYSRVGRQ--ELEFEPVdlnELLEEVL----EDLEP 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 228 MLDQRQQTLllpESAADITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKL---QEDDGAVMAVEDEGPGIDESKCGEL 304
Cdd:COG4251 372 RIEERGAEI---EVGPLPTVRGDPTLLRQVFQNLISNAIKYSRPGEPPRIEIgaeREGGEWVFSVRDNGIGIDPEYAEKI 448
|
330 340 350
....*....|....*....|....*....|...
gi 16131938 305 SKAFVRMDSR--YGGIGLGLSIVSRITQLHHGQ 335
Cdd:COG4251 449 FEIFQRLHSRdeYEGTGIGLAIVKKIVERHGGR 481
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
62-335 |
4.34e-21 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 94.07 E-value: 4.34e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 62 IREAVASLIVPGVFMVSLTLFICYQAVRRITRPLAELQKELEARTADNL-TPIAIHSATLEIEAVVSALNDLVSRLTSTL 140
Cdd:PRK09835 180 INDLKNKLIMTASVISLLIVFIVLLAVHKGHAPIRSVSRQIQNITSKDLdVRLDPQTVPIELEQLVLSFNHMIERIEDVF 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 141 DNERLFTADVAHELRTPLAGVRLHLEL-LAKTHHI----DVapLVARLDQ---MMESVSQLLQLARAGqsfssgNYQHVk 212
Cdd:PRK09835 260 TRQSNFSADIAHEIRTPITNLITQTEIaLSQSRSQkeleDV--LYSNLEEltrMAKMVSDMLFLAQAD------NNQLI- 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 213 lLEDVILPSYDELSTMLD-------QRQQTLLLPESAAdiTVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDDGA 285
Cdd:PRK09835 331 -PEKKMLDLADEVGKVFDffeawaeERGVELRFVGDPC--QVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQ 407
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 16131938 286 V-MAVEDEGPGIDESKCGELSKAFVRMD---SRYG-GIGLGLSIVSRITQLHHGQ 335
Cdd:PRK09835 408 VqLVVENPGTPIAPEHLPRLFDRFYRVDpsrQRKGeGSGIGLAIVKSIVVAHKGT 462
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
48-334 |
5.87e-21 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 93.74 E-value: 5.87e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 48 LRDNRNNDRHIMREIREAVASLIVPGVFMVSLTLFICYQAVRRITRPLAELQKELEArtADNLTPIAIHSATlEIEAVVS 127
Cdd:NF012163 148 ERLTRNTDINFDSQQKRASWLIVALALLLAALAAFLLARGLLAPVKRLVEATHRLAA--GDYTTRVTPTSND-ELGKLAQ 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 128 ALNDLVSRLTSTLDNERLFTADVAHELRTPLAGVRLHLELLAKthhiDVAPLV-ARLDQMMESVSQLLQ----LARAGQS 202
Cdd:NF012163 225 DFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRAELEAIQD----GIRKFTpESLDSLQAEVGTLTKlvddLHDLSMS 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 203 FSSG-NYQHVKL-LEDVILPSYDELSTMLDQRQQTLLLpESAADITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKL- 279
Cdd:NF012163 301 DEGAlAYQKASVdLVPLLEVEGGAFRERFASAGLELEV-SLPDSSLVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISAs 379
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 16131938 280 QEDDGAVMAVEDEGPGIDESKCGELSKAFVRMDSRY----GGIGLGLSIVSRITQLHHG 334
Cdd:NF012163 380 QRPKEVTLTVADSAPGVSDEQLARLFERFYRVEVSRnrasGGSGLGLAISLNIVQAHGG 438
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
79-345 |
4.08e-20 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 90.05 E-value: 4.08e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 79 LTLFICYQAVRRITRP---LAELQKE-----LEARTADNltpiAIHSAtlEIEAVVSALNDLVSRLTSTLDNERLFTADV 150
Cdd:NF012226 72 ISLIIGMKLAQRFIVPinfLADAAKKisqgdLSARAEDS----QIHSA--EISELMHNFNDMAQKLESSVKNAQVWNAAI 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 151 AHELRTP---LAGvRLHlELLAKTHHIDVAPLVARLDQmMESVSQLLQLARAGQSFSSG----NYQHVKLLEDVilpsyD 223
Cdd:NF012226 146 AHELRTPitiLQG-RLQ-GILDGVFEPDPALFKSLLNQ-VEGLSHLVEDLRTLSLVENQqlrlNYESVDLKDSI-----E 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 224 ELSTMLDQR-QQTLLLPEsaADIT---VQGDATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDDGAVMAVEDEGPGIDES 299
Cdd:NF012226 218 KVLKMFEDRlEQAQLTIV--LNLTatpVFCDRRRIEQVLIALIDNAIRYANAGKLKISSSVIQDDWILQIEDEGPGIAEE 295
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 16131938 300 KCGELSKAFVRM-DSR---YGGIGLGLSIVSRITQLHHGQFFLQNRQETS 345
Cdd:NF012226 296 YQQDLFNPFFRLeQSRnkeFGGTGLGLAVVHAIVIAHKGSIEYSNSQGNS 345
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
89-334 |
6.29e-20 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 90.76 E-value: 6.29e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 89 RRITRPLAELQKELEARTADNLtpiAIH----SATLEIEAVVSALNDLVSRLTSTLDNERLFTADVAHELRTPLAGVRLH 164
Cdd:PRK09470 188 WSLAKPARKLKNAADEVAQGNL---RQHpeleTGPQEFRQAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQLA 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 165 LELL-------AKTHHIDVAplVARLDQMmesVSQLLQLARAgqsfssgnyQHVKLLEDVILPSYDELSTMLD------- 230
Cdd:PRK09470 265 TALLrrrqgesKELERIETE--AQRLDSM---INDLLVLSRN---------QQKNHLERETFKANSLWSEVLEdakfeae 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 231 QRQQTLLLPESAADITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKLQeDDGAVMAVEDEGPGIDESKCGELSKAFVR 310
Cdd:PRK09470 331 QMGKSLTVSAPPGPWPINGNPNALASALENIVRNALRYSHTKIEVAFSVD-KDGLTITVDDDGPGVPEEEREQIFRPFYR 409
|
250 260
....*....|....*....|....*...
gi 16131938 311 MDS----RYGGIGLGLSIVSRITQLHHG 334
Cdd:PRK09470 410 VDEardrESGGTGLGLAIVENAIQQHRG 437
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
64-353 |
2.78e-19 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 89.42 E-value: 2.78e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 64 EAVASLIVPGVFMVSLTLFIcyQAVR---RITRplaeLQKELEArTADNLTPI--AIHSATL--EIEAVVSALNDLVSRL 136
Cdd:TIGR03785 406 EKLFNVILAIMSIGTLALFG--FASWiswRIRR----LSDDAEA-AIDSQGRIsgAIPASRSrdEIGDLSRSFAQMVARL 478
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 137 TSTLDNERLFTADVAHELRTPLAGVRLHLELLA-------KTHHIDVAPL-VARLDQMMESVSqllQLARAGQSFSSGNY 208
Cdd:TIGR03785 479 RQYTHYLENMSSRLSHELRTPVAVVRSSLENLElqaleqeKQKYLERAREgTERLSMILNNMS---EATRLEQAIQSAEV 555
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 209 QHVKLLEdvILPSYDELSTMLDQRQQ-TLLLPESaaDITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDDGAVM 287
Cdd:TIGR03785 556 EDFDLSE--VLSGCMQGYQMTYPPQRfELNIPET--PLVMRGSPELIAQMLDKLVDNAREFSPEDGLIEVGLSQNKSHAL 631
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16131938 288 -AVEDEGPGIDESKCGELSKAFVRM----DSRYGGIGLGLSIVSRITQLHHGQFFLQNRQETSGTRAWVRL 353
Cdd:TIGR03785 632 lTVSNEGPPLPEDMGEQLFDSMVSVrdqgAQDQPHLGLGLYIVRLIADFHQGRIQAENRQQNDGVVFRISL 702
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
144-335 |
9.89e-19 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 86.99 E-value: 9.89e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 144 RLFTADVAHELRTPLAGVRLHLELL----------AKTHHIdvapLVARLDQMMESVSQLLQLARAGQSfssgnyQHVKL 213
Cdd:PRK11006 205 RNFFANVSHELRTPLTVLQGYLEMMqdqplegalrEKALHT----MREQTQRMEGLVKQLLTLSKIEAA------PTIDL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 214 LEDVILPSYDEL----STMLDQRQQTLLLpESAADITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKLQE-DDGAVMA 288
Cdd:PRK11006 275 NEKVDVPMMLRVlereAQTLSQGKHTITF-EVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRvPQGAEFS 353
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 16131938 289 VEDEGPGIDESKCGELSKAFVRMD---SRY-GGIGLGLSIVSRITQLHHGQ 335
Cdd:PRK11006 354 VEDNGPGIAPEHIPRLTERFYRVDkarSRQtGGSGLGLAIVKHALSHHDSR 404
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
135-334 |
4.47e-18 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 85.07 E-value: 4.47e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 135 RLTSTLD-NE---RLFTADVAHELRTPLAGVRLHLELLA----KTHHIDVAPL---VARLDQMMESVSQLLQLARAGQSF 203
Cdd:PRK10549 228 QLASTLEkNEqmrRDFMADISHELRTPLAVLRGELEAIQdgvrKFTPESVASLqaeVGTLTKLVDDLHQLSLSDEGALAY 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 204 SSGNYQHVKLLEdVILPSYDELstmLDQRQQTL--LLPESAadiTVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKL-Q 280
Cdd:PRK10549 308 RKTPVDLVPLLE-VAGGAFRER---FASRGLTLqlSLPDSA---TVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAeQ 380
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 16131938 281 EDDGAVMAVEDEGPGIDESKCGELSKAFVRMD-SR---YGGIGLGLSIVSRITQLHHG 334
Cdd:PRK10549 381 RDKTLRLTFADSAPGVSDEQLQKLFERFYRTEgSRnraSGGSGLGLAICLNIVEAHNG 438
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
150-335 |
3.71e-17 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 82.34 E-value: 3.71e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 150 VAHELRTPLAGVRLHLELLAKTHHIDVAPLVARLDQMMESVSQLLQLARAGQsfssgnyQHVKL-LEDVILPSY-----D 223
Cdd:PRK10604 219 IAHELRTPLVRLRYRLEMSDNLSAAESQALNRDIGQLEALIEELLTYARLDR-------PQNELhLSEPDLPAWlsthlA 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 224 ELSTMLDQRQQTLLLPESAADITVqgDATLLRMLLRNLVENAHRYSPQGSNIMIKLQeDDGAVMAVEDEGPGIDESKCGE 303
Cdd:PRK10604 292 DIQAVTPEKTVRLDTPHQGDYGAL--DMRLMERVLDNLLNNALRYAHSRVRVSLLLD-GNQACLIVEDDGPGIPPEERER 368
|
170 180 190
....*....|....*....|....*....|....*.
gi 16131938 304 LSKAFVRMD-SR---YGGIGLGLSIVSRITQLHHGQ 335
Cdd:PRK10604 369 VFEPFVRLDpSRdraTGGCGLGLAIVHSIALAMGGS 404
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
142-335 |
1.31e-16 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 80.79 E-value: 1.31e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 142 NERL-----FTADVAHELRTPLAGVRLHLELLAKTHHIDVAP----LVARLDQMMESVSQLLQLARAgqsfSSGNYQHV- 211
Cdd:COG5809 264 SEKLsvvgeLAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQKTyldiMLSELDRIESIISEFLVLAKP----QAIKYEPKd 339
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 212 --KLLEDVIlpsydelstmldqrqqTLLLP-----------ESAADIT-VQGDATLLRMLLRNLVENAHRYSPQGSNIMI 277
Cdd:COG5809 340 lnTLIEEVI----------------PLLQPqallknvqielELEDDIPdILGDENQLKQVFINLLKNAIEAMPEGGNITI 403
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 278 --KLQEDDGAVMAVEDEGPGIDESKCGELSKAFvrMDSRYGGIGLGLSIVSRITQLHHGQ 335
Cdd:COG5809 404 etKAEDDDKVVISVTDEGCGIPEERLKKLGEPF--YTTKEKGTGLGLMVSYKIIEEHGGK 461
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
11-353 |
1.58e-16 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 79.84 E-value: 1.58e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 11 RQRLILTIGAILLVFELISVFWLWHESTEQIQLFEQALRDNRNNDRHIMREIREAVASLIVPGVFMVSLTLFICYQAVRR 90
Cdd:COG4191 1 ALRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 91 ITRPLAELQKELEARTADNLTPIAIHSATLEIEAVVSALNDLVSRLTST----LDNERL-----FTADVAHELRTPLAGV 161
Cdd:COG4191 81 LLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELqeqlVQSEKLaalgeLAAGIAHEINNPLAAI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 162 RLHLELLAK--THHIDVAPLVARLDQMMES-------VSQLLQLARAgqsfSSGNYQHV---KLLEDVIlpsyDELSTML 229
Cdd:COG4191 161 LGNAELLRRrlEDEPDPEELREALERILEGaeraaeiVRSLRAFSRR----DEEEREPVdlnELIDEAL----ELLRPRL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 230 DQRQQTLLLPESAADITVQGDATLLRMLLRNLVENA-----HRYSPQgsnIMIKL-QEDDGAVMAVEDEGPGIDESkcgE 303
Cdd:COG4191 233 KARGIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAidameEGEGGR---ITISTrREGDYVVISVRDNGPGIPPE---V 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 16131938 304 LSKAFvrmD------SRYGGIGLGLSIVSRITQLHHGQFFLQNRQEtSGTRAWVRL 353
Cdd:COG4191 307 LERIF---EpffttkPVGKGTGLGLSISYGIVEKHGGRIEVESEPG-GGTTFTITL 358
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
140-335 |
4.91e-16 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 79.41 E-value: 4.91e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 140 LDNER-LFTADVAHELRTPLAGVRLHLELLA----KTHhiDVAP--L-VAR--LDQMMESVSQLLQLARagqsFSSGNYQ 209
Cdd:NF033092 368 IEQERrEFVANVSHELRTPLTTMRSYLEALAdgawKDP--ELAPrfLgVTQneTERMIRLVNDLLQLSR----MDSKDYK 441
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 210 -------HVKLLEDVIlpsyDELSTMLDQRQQTLL--LPESaaDITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKLQ 280
Cdd:NF033092 442 lnkewvnFNEFFNYII----DRFEMILKNKNITFKreFPKR--DLWVEIDTDKITQVLDNIISNAIKYSPEGGTITFRLL 515
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 281 EDDG-AVMAVEDEGPGIDESKCGELSKAFVRMD---SR-YGGIGLGLSIVSRITQLHHGQ 335
Cdd:NF033092 516 ETHNrIIISISDQGLGIPKKDLDKIFDRFYRVDkarSRkMGGTGLGLAIAKEVVEAHGGR 575
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
143-334 |
1.34e-15 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 77.76 E-value: 1.34e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 143 ERLFTADVAHELRTPLAGVRLHLELLAKtHHIDVAPLVAR--------LDQMMESVSQLLQLAR--AGQsfssgnyqhVK 212
Cdd:NF040691 271 QQRFVSDVSHELRTPLTTIRMAADVIHD-SRDDFDPATARsaellhteLDRFESLLSDLLEISRfdAGA---------AE 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 213 L------LEDVILPSYDELSTMLDQRQQTLLLPESAADITVQGDATLLRMLLRNLVENAHRYSpQGSNIMIKLQEDDGAV 286
Cdd:NF040691 341 LdvepvdLRPLVRRVVDALRQLAERAGVELRVDAPGTPVVAEVDPRRVERVLRNLVVNAIEHG-EGKPVVVTVAQDDTAV 419
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 16131938 287 -MAVEDEGPGIDESKCGELSKAFVRMD-SR---YGGIGLGLSIVSRITQLHHG 334
Cdd:NF040691 420 aVTVRDHGVGLKPGEVALVFDRFWRADpARartTGGTGLGLAIALEDARLHGG 472
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
254-342 |
3.18e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 70.56 E-value: 3.18e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 254 LRMLLRNLVENAHRYSpqGSNIMIKLQ-EDDGAVMAVEDEGPGIDESKCGELSKAFVRMDSRYG--GIGLGLSIVSRITQ 330
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDgEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGtsGTGLGLAIVQRISD 78
|
90
....*....|..
gi 16131938 331 LHHGQFFLQNRQ 342
Cdd:cd16950 79 AHGGSLTLANRA 90
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
258-353 |
4.36e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 70.43 E-value: 4.36e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 258 LRNLVENAHRYSPQGSNIMIKlQEDDGAVMAVEDEGPGIDESKCGELSKAFVRMDSRY----GGIGLGLSIVSRITQLHH 333
Cdd:cd16949 5 LENVLRNALRYSPSKILLDIS-QDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARdresGGTGLGLAIAERAIEQHG 83
|
90 100
....*....|....*....|
gi 16131938 334 GQFFLQNRqETSGTRAWVRL 353
Cdd:cd16949 84 GKIKASNR-KPGGLRVRIWL 102
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
150-335 |
8.53e-15 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 74.50 E-value: 8.53e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 150 VAHELRTPLAGVRLHLELLAktHHIDVAPLVARLDQMMES-------VSQLLQLARAgqsfSSGNYQHV---KLLEDVIl 219
Cdd:COG3852 142 LAHEIRNPLTGIRGAAQLLE--RELPDDELREYTQLIIEEadrlnnlVDRLLSFSRP----RPPEREPVnlhEVLERVL- 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 220 psydelstmldqrqqTLLLPESAADITVQ-----------GDATLLRMLLRNLVENAHRYSPQGSNIMIK---------- 278
Cdd:COG3852 215 ---------------ELLRAEAPKNIRIVrdydpslpevlGDPDQLIQVLLNLVRNAAEAMPEGGTITIRtrverqvtlg 279
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16131938 279 -LQEDDGAVMAVEDEGPGIDESkcgELSKAFvrmD----SRYGGIGLGLSIVSRITQLHHGQ 335
Cdd:COG3852 280 gLRPRLYVRIEVIDNGPGIPEE---ILDRIF---EpfftTKEKGTGLGLAIVQKIVEQHGGT 335
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
121-334 |
1.15e-14 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 74.77 E-value: 1.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 121 EIEAVVSALNDlVSRLTST----LDNERL-----FTADVAHELRTPLAGVRLHLELLA-----KTHHIDVapLVARLDQM 186
Cdd:COG5805 257 SVKGILVILRD-ITEKKEAeelmARSEKLsiagqLAAGIAHEIRNPLTSIKGFLQLLQpgiedKEEYFDI--MLSELDRI 333
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 187 MESVSQLLQLARAGQ-SFSSGNYQhvKLLEDVIlpsydelstMLDQRQQTL-----LLPESAADITVQGDATLLRMLLRN 260
Cdd:COG5805 334 ESIISEFLALAKPQAvNKEKENIN--ELIQDVV---------TLLETEAILhniqiRLELLDEDPFIYCDENQIKQVFIN 402
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16131938 261 LVENAHRYSPQGSNIMIKLQEDDGAVM-AVEDEGPGIDESKCGELSKAFVRMDSRygGIGLGLSIVSRITQLHHG 334
Cdd:COG5805 403 LIKNAIEAMPNGGTITIHTEEEDNSVIiRVIDEGIGIPEERLKKLGEPFFTTKEK--GTGLGLMVSYKIIENHNG 475
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
254-354 |
1.60e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 69.06 E-value: 1.60e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 254 LRMLLRNLVENAHRYSPQGS-NIMIKLQEDDGAV----MAVEDEGPGIDESKCGELSKAFVRMDS----RYGGIGLGLSI 324
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEvTLRVSLEEEEEDGvqlrFSVEDTGIGIPEEQQARLFEPFSQADSsttrKYGGTGLGLAI 80
|
90 100 110
....*....|....*....|....*....|
gi 16131938 325 VSRITQLHHGQFFLQNRQEtSGTRAWVRLK 354
Cdd:cd16922 81 SKKLVELMGGDISVESEPG-QGSTFTFTLP 109
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
137-343 |
2.84e-14 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 74.30 E-value: 2.84e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 137 TSTLDNER------LFTAdVAHELRTPLAGVRLHLELL------AKTHHidvAPLVARLDQMMES----VSQLLQLARag 200
Cdd:PRK10490 653 QARLASEReqlrnaLLAA-LSHDLRTPLTVLFGQAEILtldlasEGSPH---ARQASEIRQQVLNttrlVNNLLDMAR-- 726
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 201 qsFSSGNYQHVK---LLEDVILPSYDELSTMLDQRQQTLLLPesaADIT-VQGDATLLRMLLRNLVENAHRYSPQGSNIM 276
Cdd:PRK10490 727 --IQSGGFNLRKewlTLEEVVGSALQMLEPGLSGHPINLSLP---EPLTlIHVDGPLFERVLINLLENAVKYAGAQAEIG 801
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 277 IKLQ-EDDGAVMAVEDEGPGIDESKCGELSKAFVRMD--SRYGGIGLGLSIVSRITQLHHGQFFLQNRQE 343
Cdd:PRK10490 802 IDAHvEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNkeSAIPGVGLGLAICRAIVEVHGGTIWAENRPE 871
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
250-350 |
5.90e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 67.10 E-value: 5.90e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 250 DATLLRMLLRNLVENAHRYSPQGSNIMIKLQ-EDDGAVMAVEDEGPGIDE---SKCGELSKAFVRMDSRYGGIGLGLSIV 325
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEaDTEGIELLVFDEGSGIPDyalNRVFERFYSLPRPHSGQKSTGLGLAFV 80
|
90 100
....*....|....*....|....*
gi 16131938 326 SRITQLHHGQFFLQNRQETSGTRAW 350
Cdd:cd16945 81 QEVAQLHGGRITLRNRPDGVLAFLT 105
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
250-334 |
1.10e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 66.72 E-value: 1.10e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 250 DATLLRMLLRNLVENAHRYSPQGSNIMIKL-QEDDGAVMAVEDEGPGIDESKCGELSKAFVRMDSR----YGGIGLGLSI 324
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAaQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSrnraSGGSGLGLAI 80
|
90
....*....|
gi 16131938 325 VSRITQLHHG 334
Cdd:cd16946 81 CHNIALAHGG 90
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
150-335 |
5.35e-13 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 69.21 E-value: 5.35e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 150 VAHELRTPLAGVRLHLELLAKTHHIDVAPLVARLD-----------QMMESVSQ-LLQLARAGQSFSSGNYQHV---KLL 214
Cdd:PRK09303 158 LAHDLRTPLTAASLALETLELGQIDEDTELKPALIeqlqdqarrqlEEIERLITdLLEVGRTRWEALRFNPQKLdlgSLC 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 215 EDVILpsydELSTMLDQRQQTLLlpesaADI-----TVQGDATLLRMLLRNLVENAHRYSPQGSNIMI--------KLQe 281
Cdd:PRK09303 238 QEVIL----ELEKRWLAKSLEIQ-----TDIpsdlpSVYADQERIRQVLLNLLDNAIKYTPEGGTITLsmlhrttqKVQ- 307
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 16131938 282 ddgavMAVEDEGPGIDESkcgELSKAF---VRM--DSRYGGIGLGLSIVSRITQLHHGQ 335
Cdd:PRK09303 308 -----VSICDTGPGIPEE---EQERIFedrVRLprDEGTEGYGIGLSVCRRIVRVHYGQ 358
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
148-339 |
1.70e-12 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 68.90 E-value: 1.70e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 148 ADVAHELRTPLAGVRLHLELLAKThhidvaPLVAR----LDQMMESVSQLLQLARAGQSFS---SG----NYQHVKLLEd 216
Cdd:PRK15347 403 TTISHEIRTPLNGVLGALELLQNT------PLTAEqmdlADTARQCTLSLLAIINNLLDFSrieSGqmtlSLEETALLP- 475
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 217 vilpsydelstMLDQRQQTLLLPESAADITVQG------------DATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDDG 284
Cdd:PRK15347 476 -----------LLDQAMLTIQGPAQSKSLTLRTfvgahvplylhlDSLRLRQILVNLLGNAVKFTETGGIRLRVKRHEQQ 544
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 16131938 285 AVMAVEDEGPGIDESKCGELSKAFVRMDSRYGGIGLGLSIVSRITQLHHGQFFLQ 339
Cdd:PRK15347 545 LCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQGTGLGLTIASSLAKMMGGELTLF 599
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
254-332 |
1.87e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 62.99 E-value: 1.87e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 254 LRMLLRNLVENAHRYSPQGSNIMIKLQEDD-GAVMAVEDEGPGIDESKCGELSKAFVRMD----SRYGGIGLGLSIVSRI 328
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEEsGARLSVEDTGPGIPPEHIPRLTERFYRVDiercRNTGGTGLGLAIVKHV 80
|
....
gi 16131938 329 TQLH 332
Cdd:cd16952 81 MSRH 84
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
87-330 |
8.39e-12 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 66.47 E-value: 8.39e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 87 AVRRITRPLAELQKELEARTADnLTPIAIHSATLEIEAvvsalnDLVSRLTSTldnerlFTADVAHELRTPLAGVRLHLE 166
Cdd:PRK11466 401 NVHALNRHREQLAAQVKARTAE-LQELVIEHRQARAEA------EKASQAKSA------FLAAMSHEIRTPLYGILGTAQ 467
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 167 LLAKThhidvaPLVAR----LDQMMESVSQLLQLARAGQSFSS--GNYQHVKLLEDVILPS--YDELSTMLDQR--QQTL 236
Cdd:PRK11466 468 LLADN------PALNAqrddLRAITDSGESLLTILNDILDYSAieAGGKNVSVSDEPFEPRplLESTLQLMSGRvkGRPI 541
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 237 LLPESAADI---TVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDDGAVMAVEDEGPGIDESKCGELSKAFVRMDS 313
Cdd:PRK11466 542 RLATDIADDlptALMGDPRRIRQVITNLLSNALRFTDEGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSG 621
|
250
....*....|....*..
gi 16131938 314 RYGGIGLGLSIVSRITQ 330
Cdd:PRK11466 622 KRGGTGLGLTISSRLAQ 638
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
258-334 |
2.83e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 59.75 E-value: 2.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 258 LRNLVENAHRYSPQGSNIMIKLQeDDGAVMAVEDEGPGIDESKCGELSKAFVRMDS----RYGGIGLGLSIVSRITQLHH 333
Cdd:cd16939 5 LDNLLRNALRYAHRTVRIALLVS-GGRLTLIVEDDGPGIPAAARERVFEPFVRLDPsrdrATGGFGLGLAIVHRVALWHG 83
|
.
gi 16131938 334 G 334
Cdd:cd16939 84 G 84
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
143-354 |
2.93e-10 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 61.52 E-value: 2.93e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 143 ERL-----FTADVAHELRTPLAGVRLHLELLAK----THHIDVAPLVAR-LDQMMESVSQLLQLARAGQSfssgNYQHV- 211
Cdd:PRK11360 385 ERLaalgeLVAGVAHEIRNPLTAIRGYVQIWRQqtsdPPSQEYLSVVLReVDRLNKVIDQLLEFSRPRES----QWQPVs 460
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 212 ---------KLLEDVILPSYDELSTMLDQRqqtllLPesaadiTVQGDATLLRMLLRNLVENAHRYSPQGSNIMI--KLQ 280
Cdd:PRK11360 461 lnalveevlQLFQTAGVQARVDFETELDNE-----LP------PIWADPELLKQVLLNILINAVQAISARGKIRIrtWQY 529
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16131938 281 EDDGAVMAVEDEGPGIDESKCGELSKAFvrMDSRYGGIGLGLSIVSRITQLHHGQFFLQNRQEtSGTRAWVRLK 354
Cdd:PRK11360 530 SDGQVAVSIEDNGCGIDPELLKKIFDPF--FTTKAKGTGLGLALSQRIINAHGGDIEVESEPG-VGTTFTLYLP 600
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
245-341 |
1.48e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 55.60 E-value: 1.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 245 ITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDDGAV-MAVEDEGPGIDESkcgELSKAFVRM-------DSRYG 316
Cdd:cd16947 12 IYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVyIDIWDKGKGISET---EKDHVFERLytledsrNSAKQ 88
|
90 100
....*....|....*....|....*
gi 16131938 317 GIGLGLSIVSRITQLHHGQFFLQNR 341
Cdd:cd16947 89 GNGLGLTITKRLAESMGGSIYVNSK 113
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
250-354 |
2.60e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 54.08 E-value: 2.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 250 DATLLRMLLRNLVENAH-----RYSPQGS-NIMIKLQEDDGAVMAVEDEGPGIDESKCGELSKAFVrmDSRYGGIGLGLS 323
Cdd:cd16944 1 DTTQISQVLTNILKNAAeaiegRPSDVGEvRIRVEADQDGRIVLIVCDNGKGFPREMRHRATEPYV--TTRPKGTGLGLA 78
|
90 100 110
....*....|....*....|....*....|.
gi 16131938 324 IVSRITQLHHGQFFLQNRQETSgtrAWVRLK 354
Cdd:cd16944 79 IVKKIMEEHGGRISLSNREAGG---ACIRII 106
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
223-353 |
3.26e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 54.56 E-value: 3.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 223 DELSTMLD---QRQQTLLLPESAADITVQGDATLLRMLLRNLVENAHRYSpqGSNIMIKLQEDDGAV-MAVEDEGPGIDE 298
Cdd:cd16954 4 DSLCSALNkvyQRKGVSISLDISPELRFPGERNDLMELLGNLLDNACKWC--LEFVEVTARQTDGGLhLIVDDDGPGVPE 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 16131938 299 SKCGELSKAFVRMDSRYGGIGLGLSIVSRITQLHHGQFFLqNRQETSGTRAWVRL 353
Cdd:cd16954 82 SQRSKIFQRGQRLDEQRPGQGLGLAIAKEIVEQYGGELSL-SDSPLGGARFEVVF 135
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
56-355 |
3.27e-09 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 58.11 E-value: 3.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 56 RHIMREIREAVASLIVPGVFMVSLTLFICYQAVRRITRPLAELQKELEARTADNLTPIAIHSaTLEIEAVVSALNDLVSR 135
Cdd:COG2972 146 SELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVRLEVSG-NDEIGILARSFNEMVER 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 136 LTSTLDNERlftadvAHELRtplagvRLHLEL---------------------LAKTHHIDvaplvaRLDQMMESVSQLL 194
Cdd:COG2972 225 IKELIEEVY------ELELE------KKEAELkalqaqinphflfntlnsirwLAELEDPE------EAEEMLEALSKLL 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 195 QlaragQSFSSGNyQHVKLLEDV-ILPSY---------DELSTMLDqrqqtllLPESAADITVqgdatlLRMLLRNLVEN 264
Cdd:COG2972 287 R-----YSLSKGD-ELVTLEEELeLIKSYleiqklrfgDRLEVEIE-------IDEELLDLLI------PKLILQPLVEN 347
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 265 A--H--RYSPQGSNIMIKLQEDDGAVM-AVEDEGPGIDESKcgeLSKAFVRMDSRYGGIGLGLSIVSRITQLHHG---QF 336
Cdd:COG2972 348 AieHgiEPKEGGGTIRISIRKEGDRLViTVEDNGVGMPEEK---LEKLLEELSSKGEGRGIGLRNVRERLKLYYGeeyGL 424
|
330
....*....|....*....
gi 16131938 337 FLQNRQETsGTRAWVRLKK 355
Cdd:COG2972 425 EIESEPGE-GTTVTIRIPL 442
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
254-348 |
3.51e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 53.87 E-value: 3.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 254 LRMLLRNLVENAHRYSPQGSNIMIKLQEDDGA---VMAVEDEGPGIDESKCGELSKAFVRMDSR--YGGIGLGLSIVSRI 328
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEDVGeewTFYVRDNGIGIDPEYAEKVFGIFQRLHSReeYEGTGVGLAIVRKI 80
|
90 100
....*....|....*....|
gi 16131938 329 TQLHHGQFFLQNrQETSGTR 348
Cdd:cd16921 81 IERHGGRIWLES-EPGEGTT 99
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
254-336 |
9.00e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 52.39 E-value: 9.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 254 LRMLLRNLVENAHRYSPQGSNIMIK-LQEDDGAVMAVEDEGPGIDESKCGELSKAFVRMD-SRY-GGIGLGLSIVSRITQ 330
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITsFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDnSRNtEGAGLGLSIAKAIIE 80
|
....*.
gi 16131938 331 LHHGQF 336
Cdd:cd16923 81 LHGGSA 86
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
250-334 |
1.94e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 51.90 E-value: 1.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 250 DATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDDGAV-MAVEDEGPGIDESkcgELSKAFVRMDSRYGG------IGLGL 322
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVvLSIKDFGIGIPEE---DLPRVFDKGFTGENGrnfqesTGMGL 78
|
90
....*....|...
gi 16131938 323 SIVSRIT-QLHHG 334
Cdd:cd16948 79 YLVKKLCdKLGHK 91
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
93-335 |
3.93e-08 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 54.64 E-value: 3.93e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 93 RP---LAELQKELEARTADNLTPiaihSATLEIEAVVSALNDLVSRLTSTLDNERLFTADVAHELRTPLAGVRLHLELL- 168
Cdd:PRK10815 217 RPieaLAKQVRELEEGEREQLDP----NPPRELTSLVRNLNRLLKNERERYTKYRTTLTDLTHSLKTPLAVLQSTLRSLr 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 169 -AKTHHIDVAPLVarldqMMESVSQLLQ-----LARAgqSFSSGnyqHVKLLEDV--ILPSYDELSTMLD---QRQQTLL 237
Cdd:PRK10815 293 sGKQMSVEQAEPI-----MLEQISRISQqigyyLHRA--SMRSE---HNLLSRELhsVAPLLDNLTSALNkvyQRKGVNI 362
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 238 LPESAADITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIkLQEDDGAVMAVEDEGPGIDESKCGELSKAFVRMDSRYGG 317
Cdd:PRK10815 363 TLDISPEITFVGEKNDFMEVMGNVLDNACKYCLEFVEISA-RQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRPG 441
|
250
....*....|....*...
gi 16131938 318 IGLGLSIVSRITQLHHGQ 335
Cdd:PRK10815 442 QGLGLSVAREITEQYEGK 459
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
250-334 |
4.34e-08 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 50.95 E-value: 4.34e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 250 DATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDD--GAVMAVEDEGPGIDESKCGELSKAFVRMDS----RYGGIGLGLS 323
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRlnRFLLTVSDSGPGIPPNLREEIFERFRQGDGsstrAHGGTGLGLS 80
|
90
....*....|.
gi 16131938 324 IVSRITQLHHG 334
Cdd:cd16925 81 IVKEFVELHGG 91
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
144-198 |
7.00e-08 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 48.75 E-value: 7.00e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16131938 144 RLFTADVAHELRTPLAGVRLHLELLAKTHHID------VAPLVARLDQMMESVSQLLQLAR 198
Cdd:cd00082 5 GEFLANVSHELRTPLTAIRGALELLEEELLDDeeqreyLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
257-335 |
1.10e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 49.32 E-value: 1.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 257 LLRNLVENAHRYSPQGSNIMIKL-QEDDGAV-MAVEDEGPGIDESKCGELSKAFVrmDSRYGGIGLGLSIVSRITQLHHG 334
Cdd:cd16920 8 LVRNGIEAMSEGGCERRELTIRTsPADDRAVtISVKDTGPGIAEEVAGQLFDPFY--TTKSEGLGMGLSICRSIIEAHGG 85
|
.
gi 16131938 335 Q 335
Cdd:cd16920 86 R 86
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
254-353 |
1.51e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 49.11 E-value: 1.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 254 LRMLLRNLVENAHRYSP--QGSNIMIKLQEDDGAVMAVEDEGPGIDESKcgeLSKAFVRMDSR------YG-GIGLGLSI 324
Cdd:cd16953 1 LGQVLRNLIGNAISFSPpdTGRITVSAMPTGKMVTISVEDEGPGIPQEK---LESIFDRFYTErpaneaFGqHSGLGLSI 77
|
90 100 110
....*....|....*....|....*....|..
gi 16131938 325 VSRITQLHHGQFFLQNRQE---TSGTRAWVRL 353
Cdd:cd16953 78 SRQIIEAHGGISVAENHNQpgqVIGARFTVQL 109
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
144-201 |
1.72e-07 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 47.59 E-value: 1.72e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16131938 144 RLFTADVAHELRTPLAGVRLHLELLAKTHHIDVAP-----LVARLDQMMESVSQLLQLARAGQ 201
Cdd:pfam00512 3 SEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQReyletILRSAERLLRLINDLLDLSRIEA 65
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
247-337 |
2.79e-07 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 52.54 E-value: 2.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 247 VQGDATLLRMLLRNLVENAHRYSPQGsNIMIKL----QEDDGAVMAVE--DEGPGIDESKCGELSKAFVRMDS----RYG 316
Cdd:PRK11107 402 VIGDPLRLQQIITNLVGNAIKFTESG-NIDILVelraLSNTKVQLEVQirDTGIGISERQQSQLFQAFRQADAsisrRHG 480
|
90 100 110
....*....|....*....|....*....|..
gi 16131938 317 GIGLGLSIVSRI-----------TQLHHGQFF 337
Cdd:PRK11107 481 GTGLGLVITQKLvnemggdisfhSQPNRGSTF 512
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
144-201 |
3.96e-07 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 46.79 E-value: 3.96e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16131938 144 RLFTADVAHELRTPLAGVRLHLELLAKTHHID-----VAPLVARLDQMMESVSQLLQLARAGQ 201
Cdd:smart00388 3 REFLANLSHELRTPLTAIRGYLELLLDTELSEeqreyLETILREAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
250-354 |
1.91e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 45.92 E-value: 1.91e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 250 DATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDDGAV-MAVEDEGPGIDESKCGELSKAFVRMD-SRYGG--IGLGLSIV 325
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLyFEIWDNGHGFSEQDLKKALELFYRDDtSRRSGghYGMGLYIA 80
|
90 100
....*....|....*....|....*....
gi 16131938 326 SRITQLHHGQFFLQNRQETSgtrAWVRLK 354
Cdd:cd16975 81 KNLVEKHGGSLIIENSQKGG---AEVTVK 106
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
150-338 |
2.64e-06 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 49.30 E-value: 2.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 150 VAHELRTPLAGVRLHLELLAK-THHIDVAPLVARLDQMMESVSQLLQLARAGQSFS--SGNYQHVKLLEDVILPSYDELS 226
Cdd:COG4192 440 LAHELNQPLNAMSMYLFSAKKaLEQENYAQLPTSLDKIEGLIERMDKIIKSLRQFSrkSDTPLQPVDLRQVIEQAWELVE 519
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 227 TMLDQRQQTLLLPEsaaDITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKLQEDDGAV-MAVEDEGPGIDESKcgELS 305
Cdd:COG4192 520 SRAKPQQITLHIPD---DLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLrVAISDNGNGWPLVD--KLF 594
|
170 180 190
....*....|....*....|....*....|...
gi 16131938 306 KAFVrmDSRYGGIGLGLSIVSRITQLHHGQFFL 338
Cdd:COG4192 595 TPFT--TTKEVGLGLGLSICRSIMQQFGGDLYL 625
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
253-334 |
2.78e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 45.49 E-value: 2.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 253 LLRMLLRNLVENAHRYSPQGSNIMIKL-QEDDGAVMAVEDEGPGIDESKCGELSKAFVRMDSRYGGIGLGLSIVSRITQL 331
Cdd:cd16943 3 QLNQVLLNLLVNAAQAMEGRGRITIRTwAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEGTGLGLSLSYRIIQK 82
|
...
gi 16131938 332 HHG 334
Cdd:cd16943 83 HGG 85
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
146-340 |
2.16e-05 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 46.65 E-value: 2.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 146 FTADVAHELRTPLAGVRLHLEL-----LAKTHHIDVAPLVARLDQ-MMESVSQLLQLARagqsFSSGNYQhvklledvIL 219
Cdd:PRK09959 715 FLATMSHEIRTPISSIMGFLELlsgsgLSKEQRVEAISLAYATGQsLLGLIGEILDVDK----IESGNYQ--------LQ 782
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 220 PSYDELSTMLDQRQQTLLLPESAADIT------------VQGDATLLRMLLRNLVENAHRYSPQGS-NIMIKLQ--EDDG 284
Cdd:PRK09959 783 PQWVDIPTLVQNTCHSFGAIAASKSIAlscsstfpdhylVKIDPQAFKQVLSNLLSNALKFTTEGAvKITTSLGhiDDNH 862
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 285 AV--MAVEDEGPGIDESKCGELSKAFVRMDS--RYGGIGLGLSIVSRITQLHHGQFFLQN 340
Cdd:PRK09959 863 AVikMTIMDSGSGLSQEEQQQLFKRYSQTSAgrQQTGSGLGLMICKELIKNMQGDLSLES 922
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
146-335 |
2.43e-05 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 46.09 E-value: 2.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 146 FTADVAHELRTPLAG-VRLHLELL-----------AKTHHIDVAPL------VARLDQMMEsvsQLLQLARAGQSFSSgn 207
Cdd:PRK11091 286 FISTISHELRTPLNGiVGLSRILLdteltaeqrkyLKTIHVSAITLgnifndIIDMDKMER---RKLQLDNQPIDFTD-- 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 208 yqhvkLLEDVilpsyDELSTMLDQrQQTLLL---PESAADITVQGDATLLRMLLRNLVENAHRYSPQGSnIMIKLQEDDG 284
Cdd:PRK11091 361 -----FLADL-----ENLSGLQAE-QKGLRFdlePLLPLPHKVITDGTRLRQILWNLISNAVKFTQQGG-VTVRVRYEEG 428
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16131938 285 AV--MAVEDEGPGIDESkcgELSKAFVrM-----DSRYG----GIGLGLSIVSRITQLHHGQ 335
Cdd:PRK11091 429 DMltFEVEDSGIGIPED---ELDKIFA-MyyqvkDSHGGkpatGTGIGLAVSKRLAQAMGGD 486
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
144-335 |
2.84e-05 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 45.46 E-value: 2.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 144 RLFTADVAHELRTPLAGVRLHLELLAK----------THHI-----DVAPLVARL-------DQMMESVSQLLQLARAGQ 201
Cdd:PRK11073 131 RDLVRGLAHEIKNPLGGLRGAAQLLSKalpdpalteyTKVIieqadRLRNLVDRLlgpqrpgTHVTESIHKVAERVVQLV 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 202 SFSSGnyQHVKLLEDVIlPSYDELSTMLDQRQQTLL-LPESAADITVQGDATllrMLLRNlvENAHRYSPQGSNIMIklq 280
Cdd:PRK11073 211 SLELP--DNVRLIRDYD-PSLPELAHDPDQIEQVLLnIVRNALQALGPEGGT---ITLRT--RTAFQLTLHGERYRL--- 279
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 16131938 281 eddGAVMAVEDEGPGIDESKCGELskaFVRMDS-RYGGIGLGLSIVSRITQLHHGQ 335
Cdd:PRK11073 280 ---AARIDIEDNGPGIPPHLQDTL---FYPMVSgREGGTGLGLSIARNLIDQHSGK 329
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
257-348 |
5.84e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 41.67 E-value: 5.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 257 LLRNLVENAHR--YSPQGSNIMIKLQ-EDDGAVMAVEDEGPGIDESKCGELSKAFVRMDSRYGGIGLGLSIVSRITQLHH 333
Cdd:cd16976 4 VLMNLLQNALDamGKVENPRIRIAARrLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLGLSISYGIVEEHG 83
|
90
....*....|....*
gi 16131938 334 GQFFLQNrQETSGTR 348
Cdd:cd16976 84 GRLSVAN-EEGAGAR 97
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
148-335 |
1.24e-04 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 43.62 E-value: 1.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 148 ADVAHELRTPLAGVRLHLELLAK------THHIDVAPLVARLDQMMESVSQLLQLARAgqsfSSGNYQHVKlLEDVILPS 221
Cdd:PRK10364 242 AGVAHEIRNPLSSIKGLAKYFAErapaggEAHQLAQVMAKEADRLNRVVSELLELVKP----THLALQAVD-LNDLINHS 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 222 YDELSTMLDQRQQTLLLPESAADITVQGDATLLRMLLRNLVENAHRYSPQGSNIMIKLQE-DDGAVMAVEDEGPGIDESk 300
Cdd:PRK10364 317 LQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASEsGAGVKISVTDSGKGIAAD- 395
|
170 180 190
....*....|....*....|....*....|....*.
gi 16131938 301 cgELSKAFV-RMDSRYGGIGLGLSIVSRITQLHHGQ 335
Cdd:PRK10364 396 --QLEAIFTpYFTTKAEGTGLGLAVVHNIVEQHGGT 429
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
250-356 |
4.62e-04 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 41.76 E-value: 4.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 250 DATLLRMLLRNLVENAHRYSPQGSN----IMIKLQEDDGAVM-AVEDEGPGIDESkcgELSKAFVRMDS--RYGGIGLGL 322
Cdd:COG3290 278 SDTDLVTILGNLLDNAIEAVEKLPEeerrVELSIRDDGDELViEVEDSGPGIPEE---LLEKIFERGFStkLGEGRGLGL 354
|
90 100 110
....*....|....*....|....*....|....
gi 16131938 323 SIVSRITQLHHGQFFLQNRQETsGTRAWVRLKKD 356
Cdd:COG3290 355 ALVKQIVEKYGGTIEVESEEGE-GTVFTVRLPKE 387
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
145-324 |
5.56e-04 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 41.88 E-value: 5.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 145 LFTADVAHELRTPLAGVRLHLELLaKTHhiDVAPLVARLDQMMESVSQLL----------------QLARAGQSFS---- 204
Cdd:PRK10841 449 MFLATVSHELRTPLYGIIGNLDLL-QTK--ELPKGVDRLVTAMNNSSSLLlkiisdildfskieseQLKIEPREFSprev 525
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 205 ----SGNYqhvklledviLPsydelstMLDQRQQTLL-LPESAADITVQGDATLLRMLLRNLVENAHRYSPQGsNIMIKL 279
Cdd:PRK10841 526 inhiTANY----------LP-------LVVKKRLGLYcFIEPDVPVALNGDPMRLQQVISNLLSNAIKFTDTG-CIVLHV 587
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 16131938 280 QEDDG-AVMAVEDEGPGIDESKCGELSKAFVRM----DSRYGGIGLGLSI 324
Cdd:PRK10841 588 RVDGDyLSFRVRDTGVGIPAKEVVRLFDPFFQVgtgvQRNFQGTGLGLAI 637
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
158-353 |
7.26e-04 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 40.76 E-value: 7.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 158 LAGVRLHLELLAKTHHIDVAPLVARLDQMMESVSQLLQLARAgqsfSSGNYQHVKLLEDVILPSYDELSTMLDQRQQ--- 234
Cdd:COG4585 69 LSAIKLQLEAARRLLDADPEAAREELEEIRELAREALAELRR----LVRGLRPPALDDLGLAAALEELAERLLRAAGirv 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 235 TLLLPESAADITVQGDATLLRMLlRNLVENAHRYSpQGSNIMIKLQEDDGAV-MAVEDEGPGIDESKCGElskafvrmds 313
Cdd:COG4585 145 ELDVDGDPDRLPPEVELALYRIV-QEALTNALKHA-GATRVTVTLEVDDGELtLTVRDDGVGFDPEAAPG---------- 212
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 16131938 314 ryGGIGLgLSIVSRItQLHHGQFFLQNRQEtSGTRAWVRL 353
Cdd:COG4585 213 --GGLGL-RGMRERA-EALGGTLTIGSAPG-GGTRVRATL 247
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
289-334 |
1.41e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 37.77 E-value: 1.41e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 16131938 289 VEDEGPGIDESKCGELSKAFVrmDSRYGGIGLGLSIVSRITQLHHG 334
Cdd:cd16918 48 VIDNGPGIPPDLQDTIFYPMV--SGRENGTGLGLAIAQNIVSQHGG 91
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
260-353 |
2.38e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 37.27 E-value: 2.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 260 NLVENAH----RYSPQGSNIMIKL-QEDDGAVMAVEDEGPGIDESKcgeLSKAFVRMDSR--YGGIGLGLSIVSRITQLH 332
Cdd:cd16915 7 NLIDNALdalaATGAPNKQVEVFLrDEGDDLVIEVRDTGPGIAPEL---RDKVFERGVSTkgQGERGIGLALVRQSVERL 83
|
90 100
....*....|....*....|.
gi 16131938 333 HGQFFLQNrQETSGTRAWVRL 353
Cdd:cd16915 84 GGSITVES-EPGGGTTFSIRI 103
|
|
| HATPase_YpdA-like |
cd16955 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
256-299 |
5.02e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340431 [Multi-domain] Cd Length: 102 Bit Score: 36.28 E-value: 5.02e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 16131938 256 MLLRNLVENA--HRYSPQGS----NIMIKLQEDDGAVMAVEDEGPGIDES 299
Cdd:cd16955 4 LMIQPLVENAivHGIQEKKGkgvvKISVKKQLKNRLHIAVEDNGIGISPK 53
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
257-329 |
5.85e-03 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 36.43 E-value: 5.85e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16131938 257 LLRNLVENAHRYSPQGSnIMIKLQ-EDDGAVMAVEDEGPGIDESKCGElskafvRMDSRYGGiGLGLSIVSRIT 329
Cdd:COG2172 42 AVTNAVRHAYGGDPDGP-VEVELElDPDGLEIEVRDEGPGFDPEDLPD------PYSTLAEG-GRGLFLIRRLM 107
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
89-141 |
6.37e-03 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 34.53 E-value: 6.37e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 16131938 89 RRITRPLAELQKELEARTADNLTPIAIHSATLEIEAVVSALNDLVSRLTSTLD 141
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| LytS |
COG3275 |
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms]; |
256-356 |
8.15e-03 |
|
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
Pssm-ID: 442506 [Multi-domain] Cd Length: 352 Bit Score: 37.93 E-value: 8.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131938 256 MLLRNLVENA--HRYSPQGSNIMIKL---QEDDGAVMAVEDEGPGIDESKcgelskafvrmDSRYGGIGLGlSIVSRITQ 330
Cdd:COG3275 256 LLLQPLVENAikHGISSKEGGGTISIsieVEGDRLVIEVENNGVGIQPKK-----------KKKGSGIGLK-NVRERLEL 323
|
90 100
....*....|....*....|....*..
gi 16131938 331 LHHGQFFLQ-NRQETSGTRAWVRLKKD 356
Cdd:COG3275 324 LYGDKYSLEiESTDGGGTKVTLKIPLK 350
|
|
| |
