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Conserved domains on  [gi|16418469|ref|NP_443205|]
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striatin-3 isoform 1 [Mus musculus]

Protein Classification

striatin( domain architecture ID 10548818)

striatin, a WD40 repeat protein which may function as scaffolding or signaling protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 474-795 3.68e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 213.35  E-value: 3.68e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469 474 TLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQktvpakksaslDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGID 553
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASGSSD 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469 554 ATIQWWNmpspnvdpydtYESNVLAGTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWNPqEKLPCVCTYNGdKEHGIp 633
Cdd:cd00200  73 KTIRLWD-----------LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV-ETGKCLTTLRG-HTDWV- 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469 634 TSVDFIGCDpaHMVTSF-NTGSAVIYDLETSQSLVMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHIKFFDNKTG 712
Cdd:cd00200 139 NSVAFSPDG--TFVASSsQDGTIKLWDLRTGKCVATLTGHTGE-------VNSVAFSPDGEKLLSSSSDGTIKLWDLSTG 209

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469 713 KMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALA 792
Cdd:cd00200 210 KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH----TNSVTSLAWSPDGKRLASGSADGTI 285


                ...
gi 16418469 793 KVF 795
Cdd:cd00200 286 RIW 288
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 65-190 8.23e-45

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


:

Pssm-ID: 462401  Cd Length: 85  Bit Score: 155.35  E-value: 8.23e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469    65 IPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERakyhklkygtelnqg 144
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 16418469   145 dlkmptfeseetkdveappapqnsqlTWKQGRQLLRQYLQEVGYTD 190
Cdd:pfam08232  66 --------------------------KRKKSRQYLKKCLQEIGYLD 85
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 474-795 3.68e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 213.35  E-value: 3.68e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469 474 TLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQktvpakksaslDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGID 553
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASGSSD 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469 554 ATIQWWNmpspnvdpydtYESNVLAGTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWNPqEKLPCVCTYNGdKEHGIp 633
Cdd:cd00200  73 KTIRLWD-----------LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV-ETGKCLTTLRG-HTDWV- 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469 634 TSVDFIGCDpaHMVTSF-NTGSAVIYDLETSQSLVMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHIKFFDNKTG 712
Cdd:cd00200 139 NSVAFSPDG--TFVASSsQDGTIKLWDLRTGKCVATLTGHTGE-------VNSVAFSPDGEKLLSSSSDGTIKLWDLSTG 209

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469 713 KMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALA 792
Cdd:cd00200 210 KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH----TNSVTSLAWSPDGKRLASGSADGTI 285


                ...
gi 16418469 793 KVF 795
Cdd:cd00200 286 RIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
434-794 4.02e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 200.91  E-value: 4.02e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469 434 LLSVLGLGDLADLTVTNDADYSYDLPANKDAFRKTWN-----PKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNL 508
Cdd:COG2319  70 LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDlatglLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469 509 QKTvpakksasldvEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPNvdpydtyesnvLAGTLVAHTDAV 588
Cdd:COG2319 150 ATG-----------KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK-----------LLRTLTGHTGAV 207

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469 589 WGLAYS--GikNQLLSCSADGTIRLWNPQEKlPCVCTYNGDkeHGIPTSVDFIGcDPAHMVTSFNTGSAVIYDLETSQSL 666
Cdd:COG2319 208 RSVAFSpdG--KLLASGSADGTVRLWDLATG-KLLRTLTGH--SGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELL 281

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469 667 VMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSI 746
Cdd:COG2319 282 RTLTGHSGG-------VNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTV 354

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*...
gi 16418469 747 RLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALAKV 794
Cdd:COG2319 355 RLWDLATGELLRTLTGH----TGAVTSVAFSPDGRTLASGSADGTVRL 398
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 65-190 8.23e-45

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


Pssm-ID: 462401  Cd Length: 85  Bit Score: 155.35  E-value: 8.23e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469    65 IPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERakyhklkygtelnqg 144
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 16418469   145 dlkmptfeseetkdveappapqnsqlTWKQGRQLLRQYLQEVGYTD 190
Cdd:pfam08232  66 --------------------------KRKKSRQYLKKCLQEIGYLD 85
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 711-750 5.73e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 5.73e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 16418469    711 TGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWN 750
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
712-750 1.08e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.58  E-value: 1.08e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 16418469   712 GKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWN 750
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 474-795 3.68e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 213.35  E-value: 3.68e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469 474 TLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQktvpakksaslDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGID 553
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASGSSD 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469 554 ATIQWWNmpspnvdpydtYESNVLAGTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWNPqEKLPCVCTYNGdKEHGIp 633
Cdd:cd00200  73 KTIRLWD-----------LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV-ETGKCLTTLRG-HTDWV- 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469 634 TSVDFIGCDpaHMVTSF-NTGSAVIYDLETSQSLVMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHIKFFDNKTG 712
Cdd:cd00200 139 NSVAFSPDG--TFVASSsQDGTIKLWDLRTGKCVATLTGHTGE-------VNSVAFSPDGEKLLSSSSDGTIKLWDLSTG 209

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469 713 KMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALA 792
Cdd:cd00200 210 KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH----TNSVTSLAWSPDGKRLASGSADGTI 285


                ...
gi 16418469 793 KVF 795
Cdd:cd00200 286 RIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
434-794 4.02e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 200.91  E-value: 4.02e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469 434 LLSVLGLGDLADLTVTNDADYSYDLPANKDAFRKTWN-----PKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNL 508
Cdd:COG2319  70 LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDlatglLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469 509 QKTvpakksasldvEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPNvdpydtyesnvLAGTLVAHTDAV 588
Cdd:COG2319 150 ATG-----------KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK-----------LLRTLTGHTGAV 207

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469 589 WGLAYS--GikNQLLSCSADGTIRLWNPQEKlPCVCTYNGDkeHGIPTSVDFIGcDPAHMVTSFNTGSAVIYDLETSQSL 666
Cdd:COG2319 208 RSVAFSpdG--KLLASGSADGTVRLWDLATG-KLLRTLTGH--SGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELL 281

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469 667 VMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSI 746
Cdd:COG2319 282 RTLTGHSGG-------VNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTV 354

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*...
gi 16418469 747 RLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALAKV 794
Cdd:COG2319 355 RLWDLATGELLRTLTGH----TGAVTSVAFSPDGRTLASGSADGTVRL 398
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 65-190 8.23e-45

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


Pssm-ID: 462401  Cd Length: 85  Bit Score: 155.35  E-value: 8.23e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469    65 IPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERakyhklkygtelnqg 144
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 16418469   145 dlkmptfeseetkdveappapqnsqlTWKQGRQLLRQYLQEVGYTD 190
Cdd:pfam08232  66 --------------------------KRKKSRQYLKKCLQEIGYLD 85
WD40 COG2319
WD40 repeat [General function prediction only];
467-753 3.80e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 164.31  E-value: 3.80e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469 467 KTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTvpakksasldvEPIYTFRAHIGPVLSLAISSNGEQ 546
Cdd:COG2319 150 ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG-----------KLLRTLTGHTGAVRSVAFSPDGKL 218

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469 547 CFSGGIDATIQWWNMpspnvdpydtyESNVLAGTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWNPQEKlPCVCTYNG 626
Cdd:COG2319 219 LASGSADGTVRLWDL-----------ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG-ELLRTLTG 286

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469 627 DkeHGIPTSVDFIGcDPAHMVTSFNTGSAVIYDLETSQSLVMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHIKF 706
Cdd:COG2319 287 H--SGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA-------VRSVAFSPDGKTLASGSDDGTVRL 356

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 16418469 707 FDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDS 753
Cdd:COG2319 357 WDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
474-795 2.98e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.45  E-value: 2.98e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469 474 TLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTvpakksasldvEPIYTFRAHIGPVLSLAISSNGEQCFSGGID 553
Cdd:COG2319  31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG-----------ALLATLLGHTAAVLSVAFSPDGRLLASASAD 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469 554 ATIQWWNMpspnvdpydtyESNVLAGTLVAHTDAVWGLAYS--GikNQLLSCSADGTIRLWNPQEKlPCVCTYNGDkeHG 631
Cdd:COG2319 100 GTVRLWDL-----------ATGLLLRTLTGHTGAVRSVAFSpdG--KTLASGSADGTVRLWDLATG-KLLRTLTGH--SG 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469 632 IPTSVDFIGcDPAHMVTSFNTGSAVIYDLETSQSLVMLSSqvdsglqSSNHINRVVSHP---TLpvtITAHEDRHIKFFD 708
Cdd:COG2319 164 AVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTG-------HTGAVRSVAFSPdgkLL---ASGSADGTVRLWD 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469 709 NKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGA 788
Cdd:COG2319 233 LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH----SGGVNSVAFSPDGKLLASGSD 308


                ....*..
gi 16418469 789 DALAKVF 795
Cdd:COG2319 309 DGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 577-795 9.20e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 128.22  E-value: 9.20e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469 577 LAGTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWNpQEKLPCVCTYngdKEHGIP-TSVDFIGCDPAhMVTSFNTGSA 655
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWD-LETGELLRTL---KGHTGPvRDVAASADGTY-LASGSSDKTI 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418469 656 VIYDLETSQSLVMLSSqvdsglqssnHINRVVS---HPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDP 732
Cdd:cd00200  76 RLWDLETGECVRTLTG----------HTSYVSSvafSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP 145

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16418469 733 NGIYLMSGSHDCSIRLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALAKVF 795
Cdd:cd00200 146 DGTFVASSSQDGTIKLWDLRTGKCVATLTGH----TGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 711-750 5.73e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 5.73e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 16418469    711 TGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWN 750
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
712-750 1.08e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.58  E-value: 1.08e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 16418469   712 GKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWN 750
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 468-507 1.63e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.77  E-value: 1.63e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 16418469    468 TWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWN 507
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
469-507 8.02e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 8.02e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 16418469   469 WNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWN 507
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 580-613 1.54e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.54e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 16418469    580 TLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWN 613
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
579-613 9.12e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 9.12e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 16418469   579 GTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWN 613
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
466-509 1.20e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.45  E-value: 1.20e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 16418469 466 RKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQ 509
Cdd:COG2319 359 LATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 523-560 1.37e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 1.37e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 16418469    523 EPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWN 560
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
523-560 1.20e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 1.20e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 16418469   523 EPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWN 560
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 753-795 8.29e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 8.29e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 16418469    753 SKTCVQEITAHRKkldeSIYDVAFHPSKAYIASAGADALAKVF 795
Cdd:smart00320   1 SGELLKTLKGHTG----PVTSVAFSPDGKYLASGSDDGTIKLW 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 712-777 5.49e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 39.67  E-value: 5.49e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16418469   712 GKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNL--------DSKTCVQEItaHRKklDESIYDVAFH 777
Cdd:pfam20426 114 GRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVlrgrssekRSRNTQTEF--PRK--DHVIAETPFH 183
WD40 pfam00400
WD domain, G-beta repeat;
754-795 5.80e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 5.80e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 16418469   754 KTCVQEITAHRKkldeSIYDVAFHPSKAYIASAGADALAKVF 795
Cdd:pfam00400   1 GKLLKTLEGHTG----SVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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