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Conserved domains on  [gi|148728178|ref|NP_444377|]
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protocadherin beta-15 precursor [Mus musculus]

Protein Classification

protocadherin( domain architecture ID 11175748)

protocadherin may have tightly regulated functions in the development, regionalization, and functional differentiation of the central nervous system

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 28-110 6.99e-39

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 138.81  E-value: 6.99e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178   28 PRRYFVMEETPSGTVLADLVQDLGLGVAELAARGAQVVSEEKESRLQLDLQTGKLILNEKLDREELCGSTEPCVTHFQVL 107
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 148728178  108 LKK 110
Cdd:pfam08266  81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 245-341 2.50e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.58  E-value: 2.50e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178 245 YRVQIPENSPSGSMVAKVSAKDLDTGTNGEVSYSLfhSSQEMSKTFELNALSGEVRLIKTLDFETTPSYELDIEATDGGG 324
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 148728178 325 --LSGKCSVSIQVVDVNDN 341
Cdd:cd11304   80 ppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 453-555 1.11e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.10  E-value: 1.11e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178 453 SYTMLVHENNSPALHIGTISATDSDSGSNAHITYSLLPAQEPqlalnSLISINADNGQLFALRALDYEALQAFEFHVSAT 532
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED-----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|...
gi 148728178 533 DRGSPALSSQALVRIVVLDDNDN 555
Cdd:cd11304   76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 138-236 1.12e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 1.12e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178 138 VKIIENSPVGTAFLLKTAQDLDVGNNSVQNYKI---GTNSHFHVSirnrgdgRKYPELVLDKELDREVQAAFRLTLTALD 214
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSID-------PSTGEITTAKPLDREEQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|..
gi 148728178 215 GGSPPRTGTSQIRIVVLDVNDN 236
Cdd:cd11304   77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 354-445 4.19e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.61  E-value: 4.19e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178 354 IPENSPE-TEVALFRIRDRDSGENGRTICSIQDGVP---FTLEPsveNFYRLVTDGALDREIRAEYNITISVTDLGIPKL 429
Cdd:cd11304    6 VPENAPPgTVVLTVSATDPDSGENGEVTYSIVSGNEdglFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                         90
                 ....*....|....*.
gi 148728178 430 TTQHTITVQVSDINDN 445
Cdd:cd11304   83 SSTATVTITVLDVNDN 98
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 686-768 1.31e-21

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


:

Pssm-ID: 465139  Cd Length: 84  Bit Score: 89.51  E-value: 1.31e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178  686 LTLYLVIALASVSSLFLLSVLLFVGVRLCRRAREVSLGG----CSVPEGHFPGHlvdvSGAGTLSQSYQYEVCLTGDSQS 761
Cdd:pfam16492   2 LTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSsgnlCSVPAPHFPGN----DGTGTLPQSYSYEVCLTSDSGK 77


                  ....*..
gi 148728178  762 NEFKFLK 768
Cdd:pfam16492  78 SEFKFLK 84
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 574-662 9.71e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.67  E-value: 9.71e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178 574 LPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDVPKHRLLLVVKDNGEPPRSAS 653
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSST 85


                 ....*....
gi 148728178 654 VTLQVLMVD 662
Cdd:cd11304   86 ATVTITVLD 94
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 28-110 6.99e-39

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 138.81  E-value: 6.99e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178   28 PRRYFVMEETPSGTVLADLVQDLGLGVAELAARGAQVVSEEKESRLQLDLQTGKLILNEKLDREELCGSTEPCVTHFQVL 107
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 148728178  108 LKK 110
Cdd:pfam08266  81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 245-341 2.50e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.58  E-value: 2.50e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178 245 YRVQIPENSPSGSMVAKVSAKDLDTGTNGEVSYSLfhSSQEMSKTFELNALSGEVRLIKTLDFETTPSYELDIEATDGGG 324
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 148728178 325 --LSGKCSVSIQVVDVNDN 341
Cdd:cd11304   80 ppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 453-555 1.11e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.10  E-value: 1.11e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178 453 SYTMLVHENNSPALHIGTISATDSDSGSNAHITYSLLPAQEPqlalnSLISINADNGQLFALRALDYEALQAFEFHVSAT 532
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED-----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|...
gi 148728178 533 DRGSPALSSQALVRIVVLDDNDN 555
Cdd:cd11304   76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 138-236 1.12e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 1.12e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178 138 VKIIENSPVGTAFLLKTAQDLDVGNNSVQNYKI---GTNSHFHVSirnrgdgRKYPELVLDKELDREVQAAFRLTLTALD 214
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSID-------PSTGEITTAKPLDREEQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|..
gi 148728178 215 GGSPPRTGTSQIRIVVLDVNDN 236
Cdd:cd11304   77 GGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 472-557 7.22e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.18  E-value: 7.22e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178   472 SATDSDSGSNAHITYSLLPAQEpqlalNSLISINADNGQLFALRALDYEALQAFEFHVSATDRGSPALSSQALVRIVVLD 551
Cdd:smart00112   1 SATDADSGENGKVTYSILSGND-----DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 148728178   552 DNDNAP 557
Cdd:smart00112  76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 354-445 4.19e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.61  E-value: 4.19e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178 354 IPENSPE-TEVALFRIRDRDSGENGRTICSIQDGVP---FTLEPsveNFYRLVTDGALDREIRAEYNITISVTDLGIPKL 429
Cdd:cd11304    6 VPENAPPgTVVLTVSATDPDSGENGEVTYSIVSGNEdglFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                         90
                 ....*....|....*.
gi 148728178 430 TTQHTITVQVSDINDN 445
Cdd:cd11304   83 SSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 263-343 4.45e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.87  E-value: 4.45e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178   263 SAKDLDTGTNGEVSYSLfhSSQEMSKTFELNALSGEVRLIKTLDFETTPSYELDIEATDGGG--LSGKCSVSIQVVDVND 340
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVND 78


                   ...
gi 148728178   341 NYP 343
Cdd:smart00112  79 NAP 81
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 686-768 1.31e-21

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 89.51  E-value: 1.31e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178  686 LTLYLVIALASVSSLFLLSVLLFVGVRLCRRAREVSLGG----CSVPEGHFPGHlvdvSGAGTLSQSYQYEVCLTGDSQS 761
Cdd:pfam16492   2 LTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSsgnlCSVPAPHFPGN----DGTGTLPQSYSYEVCLTSDSGK 77


                  ....*..
gi 148728178  762 NEFKFLK 768
Cdd:pfam16492  78 SEFKFLK 84
Cadherin pfam00028
Cadherin domain;
245-335 1.99e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.28  E-value: 1.99e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178  245 YRVQIPENSPSGSMVAKVSAKDLDTGTNGEVSYSLfhSSQEMSKTFELNALSGEVRLIKTLDFETTPSYELDIEATDGG- 323
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI--LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGg 78

                          90
                  ....*....|...
gi 148728178  324 -GLSGKCSVSIQV 335
Cdd:pfam00028  79 pPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 574-662 9.71e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.67  E-value: 9.71e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178 574 LPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDVPKHRLLLVVKDNGEPPRSAS 653
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSST 85


                 ....*....
gi 148728178 654 VTLQVLMVD 662
Cdd:cd11304   86 ATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 154-238 1.00e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.24  E-value: 1.00e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178   154 TAQDLDVGNNSVQNYKI---GTNSHFHVsirNRGDGrkypELVLDKELDREVQAAFRLTLTALDGGSPPRTGTSQIRIVV 230
Cdd:smart00112   1 SATDADSGENGKVTYSIlsgNDDGLFSI---DPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73


                   ....*...
gi 148728178   231 LDVNDNAP 238
Cdd:smart00112  74 LDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 369-447 5.90e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.93  E-value: 5.90e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178   369 RDRDSGENGRTICSIQDGVP---FTLEPSVEnfyRLVTDGALDREIRAEYNITISVTDLGIPKLTTQHTITVQVSDINDN 445
Cdd:smart00112   3 TDADSGENGKVTYSILSGNDdglFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 148728178   446 AP 447
Cdd:smart00112  80 AP 81
Cadherin pfam00028
Cadherin domain;
454-550 2.57e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.73  E-value: 2.57e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178  454 YTMLVHENNSPALHIGTISATDSDSGSNAHITYSLLPAQEPQLalnslISINADNGQLFALRALDYEALQAFEFHVSATD 533
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 148728178  534 RGSPALSSQALVRIVVL 550
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 588-662 2.57e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 2.57e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148728178   588 VAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDVPKHRLLLVVKDNGEPPRSASVTLQVLMVD 662
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75
Cadherin pfam00028
Cadherin domain;
142-231 7.24e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.01  E-value: 7.24e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178  142 ENSPVGTAFLLKTAQDLDVGNNSVQNYKI---GTNSHFHVSIRNRgdgrkypELVLDKELDREVQAAFRLTLTALDGGSP 218
Cdd:pfam00028   7 ENAPVGTEVLTVTATDPDLGPNGRIFYSIlggGPGGNFRIDPDTG-------DISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 148728178  219 PRTGTSQIRIVVL 231
Cdd:pfam00028  80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
354-439 2.72e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.09  E-value: 2.72e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178  354 IPENSPE-TEVALFRIRDRDSGENGRTICSIQDGVP---FTLEPSVEnfyRLVTDGALDREIRAEYNITISVTDLGIPKL 429
Cdd:pfam00028   5 VPENAPVgTEVLTVTATDPDLGPNGRIFYSILGGGPggnFRIDPDTG---DISTTKPLDRESIGEYELTVEATDSGGPPL 81

                          90
                  ....*....|
gi 148728178  430 TTQHTITVQV 439
Cdd:pfam00028  82 SSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
574-658 1.43e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.16  E-value: 1.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178  574 LPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDVPKHRLLLVVKDNGEPPRSAS 653
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                  ....*
gi 148728178  654 VTLQV 658
Cdd:pfam00028  85 ATVTI 89
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 31-127 1.30e-07

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 50.04  E-value: 1.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178  31 YFVMEETPSGTVLADLVQDLGlgvaELAARGAQVVSEEKE---SRLQLDLQTGKLILNEKLDREELcgstepCVTHFQVL 107
Cdd:cd00031    4 GSAVEGRSRGSFRVSIPTDLI----ASSGEIIKISAAGKEalpSWLHWEPHSGILEGLEKLDREDK------GVHYISVS 73

                         90       100
                 ....*....|....*....|....*
gi 148728178 108 LKK-----PLEIFQAELRVGDINDH 127
Cdd:cd00031   74 AASlganvPQTSSVFSIEVYDENDN 98
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 28-110 6.99e-39

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 138.81  E-value: 6.99e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178   28 PRRYFVMEETPSGTVLADLVQDLGLGVAELAARGAQVVSEEKESRLQLDLQTGKLILNEKLDREELCGSTEPCVTHFQVL 107
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 148728178  108 LKK 110
Cdd:pfam08266  81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 245-341 2.50e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.58  E-value: 2.50e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178 245 YRVQIPENSPSGSMVAKVSAKDLDTGTNGEVSYSLfhSSQEMSKTFELNALSGEVRLIKTLDFETTPSYELDIEATDGGG 324
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 148728178 325 --LSGKCSVSIQVVDVNDN 341
Cdd:cd11304   80 ppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 453-555 1.11e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.10  E-value: 1.11e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178 453 SYTMLVHENNSPALHIGTISATDSDSGSNAHITYSLLPAQEPqlalnSLISINADNGQLFALRALDYEALQAFEFHVSAT 532
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED-----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|...
gi 148728178 533 DRGSPALSSQALVRIVVLDDNDN 555
Cdd:cd11304   76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 138-236 1.12e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 1.12e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178 138 VKIIENSPVGTAFLLKTAQDLDVGNNSVQNYKI---GTNSHFHVSirnrgdgRKYPELVLDKELDREVQAAFRLTLTALD 214
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSID-------PSTGEITTAKPLDREEQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|..
gi 148728178 215 GGSPPRTGTSQIRIVVLDVNDN 236
Cdd:cd11304   77 GGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 472-557 7.22e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.18  E-value: 7.22e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178   472 SATDSDSGSNAHITYSLLPAQEpqlalNSLISINADNGQLFALRALDYEALQAFEFHVSATDRGSPALSSQALVRIVVLD 551
Cdd:smart00112   1 SATDADSGENGKVTYSILSGND-----DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 148728178   552 DNDNAP 557
Cdd:smart00112  76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 354-445 4.19e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.61  E-value: 4.19e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178 354 IPENSPE-TEVALFRIRDRDSGENGRTICSIQDGVP---FTLEPsveNFYRLVTDGALDREIRAEYNITISVTDLGIPKL 429
Cdd:cd11304    6 VPENAPPgTVVLTVSATDPDSGENGEVTYSIVSGNEdglFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                         90
                 ....*....|....*.
gi 148728178 430 TTQHTITVQVSDINDN 445
Cdd:cd11304   83 SSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 263-343 4.45e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.87  E-value: 4.45e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178   263 SAKDLDTGTNGEVSYSLfhSSQEMSKTFELNALSGEVRLIKTLDFETTPSYELDIEATDGGG--LSGKCSVSIQVVDVND 340
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVND 78


                   ...
gi 148728178   341 NYP 343
Cdd:smart00112  79 NAP 81
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 686-768 1.31e-21

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 89.51  E-value: 1.31e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178  686 LTLYLVIALASVSSLFLLSVLLFVGVRLCRRAREVSLGG----CSVPEGHFPGHlvdvSGAGTLSQSYQYEVCLTGDSQS 761
Cdd:pfam16492   2 LTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSsgnlCSVPAPHFPGN----DGTGTLPQSYSYEVCLTSDSGK 77


                  ....*..
gi 148728178  762 NEFKFLK 768
Cdd:pfam16492  78 SEFKFLK 84
Cadherin pfam00028
Cadherin domain;
245-335 1.99e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.28  E-value: 1.99e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178  245 YRVQIPENSPSGSMVAKVSAKDLDTGTNGEVSYSLfhSSQEMSKTFELNALSGEVRLIKTLDFETTPSYELDIEATDGG- 323
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI--LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGg 78

                          90
                  ....*....|...
gi 148728178  324 -GLSGKCSVSIQV 335
Cdd:pfam00028  79 pPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 574-662 9.71e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.67  E-value: 9.71e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178 574 LPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDVPKHRLLLVVKDNGEPPRSAS 653
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSST 85


                 ....*....
gi 148728178 654 VTLQVLMVD 662
Cdd:cd11304   86 ATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 154-238 1.00e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.24  E-value: 1.00e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178   154 TAQDLDVGNNSVQNYKI---GTNSHFHVsirNRGDGrkypELVLDKELDREVQAAFRLTLTALDGGSPPRTGTSQIRIVV 230
Cdd:smart00112   1 SATDADSGENGKVTYSIlsgNDDGLFSI---DPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73


                   ....*...
gi 148728178   231 LDVNDNAP 238
Cdd:smart00112  74 LDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 369-447 5.90e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.93  E-value: 5.90e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178   369 RDRDSGENGRTICSIQDGVP---FTLEPSVEnfyRLVTDGALDREIRAEYNITISVTDLGIPKLTTQHTITVQVSDINDN 445
Cdd:smart00112   3 TDADSGENGKVTYSILSGNDdglFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 148728178   446 AP 447
Cdd:smart00112  80 AP 81
Cadherin pfam00028
Cadherin domain;
454-550 2.57e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.73  E-value: 2.57e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178  454 YTMLVHENNSPALHIGTISATDSDSGSNAHITYSLLPAQEPQLalnslISINADNGQLFALRALDYEALQAFEFHVSATD 533
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 148728178  534 RGSPALSSQALVRIVVL 550
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 588-662 2.57e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 2.57e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148728178   588 VAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDVPKHRLLLVVKDNGEPPRSASVTLQVLMVD 662
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75
Cadherin pfam00028
Cadherin domain;
142-231 7.24e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.01  E-value: 7.24e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178  142 ENSPVGTAFLLKTAQDLDVGNNSVQNYKI---GTNSHFHVSIRNRgdgrkypELVLDKELDREVQAAFRLTLTALDGGSP 218
Cdd:pfam00028   7 ENAPVGTEVLTVTATDPDLGPNGRIFYSIlggGPGGNFRIDPDTG-------DISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 148728178  219 PRTGTSQIRIVVL 231
Cdd:pfam00028  80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
354-439 2.72e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.09  E-value: 2.72e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178  354 IPENSPE-TEVALFRIRDRDSGENGRTICSIQDGVP---FTLEPSVEnfyRLVTDGALDREIRAEYNITISVTDLGIPKL 429
Cdd:pfam00028   5 VPENAPVgTEVLTVTATDPDLGPNGRIFYSILGGGPggnFRIDPDTG---DISTTKPLDRESIGEYELTVEATDSGGPPL 81

                          90
                  ....*....|
gi 148728178  430 TTQHTITVQV 439
Cdd:pfam00028  82 SSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
574-658 1.43e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.16  E-value: 1.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178  574 LPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDVPKHRLLLVVKDNGEPPRSAS 653
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                  ....*
gi 148728178  654 VTLQV 658
Cdd:pfam00028  85 ATVTI 89
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 31-127 1.30e-07

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 50.04  E-value: 1.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178  31 YFVMEETPSGTVLADLVQDLGlgvaELAARGAQVVSEEKE---SRLQLDLQTGKLILNEKLDREELcgstepCVTHFQVL 107
Cdd:cd00031    4 GSAVEGRSRGSFRVSIPTDLI----ASSGEIIKISAAGKEalpSWLHWEPHSGILEGLEKLDREDK------GVHYISVS 73

                         90       100
                 ....*....|....*....|....*
gi 148728178 108 LKK-----PLEIFQAELRVGDINDH 127
Cdd:cd00031   74 AASlganvPQTSSVFSIEVYDENDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 28-127 2.78e-03

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 37.68  E-value: 2.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728178  28 PRRYFVMEETPSGTVLADL-VQDLGLGVaelaarGAQV----VSEEKESRLQLDLQTGKLILNEKLDREELC-------- 94
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVsATDPDSGE------NGEVtysiVSGNEDGLFSIDPSTGEITTAKPLDREEQSsytltvta 74

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 148728178  95 --GSTEPCVTHFQVllkkpleifqaELRVGDINDH 127
Cdd:cd11304   75 tdGGGPPLSSTATV-----------TITVLDVNDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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