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Conserved domains on  [gi|16764889|ref|NP_460504|]
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PhoPQ-regulated protein [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]

Protein Classification

PhoPQ-activated pathogenicity-related family protein( domain architecture ID 10008460)

PhoPQ-activated pathogenicity-related family protein similar to Dictyostelium discoideum autocrine proliferation repressor protein A (AprA) that slows proliferation of secreting cells and may function by binding to cell surface receptors

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PqaA COG4287
PhoPQ-activated pathogenicity-related protein [General function prediction only];
53-493 0e+00

PhoPQ-activated pathogenicity-related protein [General function prediction only];


:

Pssm-ID: 443428  Cd Length: 440  Bit Score: 534.90  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16764889  53 NSPECdlshVLPDYREQiSGTPLKYTLINTAPLAQVVVRHYELLSQHWSPddmvtpAQWRHNVDIYIPETAKEHHALVVV 132
Cdd:COG4287  18 VTPET----ALKDYVNN-RDPPLKWELKDTTTLGGVTVYELLLTSQKWRP------ITWKHQLTIFVPKEVLPDGALLFI 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16764889 133 NNGINYDKGVQITgKPGDFPQETLASISRDTNTIVISVSDIPNQYLTFQddkkpLKEDESVSRSWALFMEAPeqRKLMPL 212
Cdd:COG4287  87 TGGSNKPEQPNWP-PPGDFDPELLAAIARKTKAIVALLSQVPNQPLFGG-----LREDALIAYTWHQFLKDP--DYTWPL 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16764889 213 NIPMVTAISQAMRLAKKELTQ---WNINSFIITGISKRGWTTWLSAIADPDVEAIVPFAIDLLDIDASLEHIYQSYGGnW 289
Cdd:COG4287 159 LFPMVKSAVRAMDAVQEFLKQelgKEIKRFVVTGASKRGWTTWLTAAADPRVKAIAPMVIDVLNMPASLEHQYKVYGG-Y 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16764889 290 PITFYPYYQQGIDEKIKSPAFTQLRQIIDPLRYLNtiyqpRLAIPKYIINASGDDFFVPDNTRFYYSKLPGVKSLRIVPN 369
Cdd:COG4287 238 SIAIEDYVKLGIPQQLGTPAGKALMQMVDPYSYRA-----RLTMPKYIVNGSNDDYWVPDAIKHYYDDLPGEKALRYVPN 312

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16764889 370 MNHYSINQF-AEGSLVPFINRFQSKKTLPQLIDLIHHH----LLTVYFSEAPVKVVRWTANNpNARDFRyacGIRYQPLT 444
Cdd:COG4287 313 AGHGLGDGKqAVEALSAFFGRTLQGRPLPQVSWKLDETgkgaRLTVASSEAPVKAKLWTATS-EDRDFR---GVRWTSRP 388

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|..
gi 16764889 445 IDSPVNNKISITLNEPKTGWEATYIEATFNDG---YVATSQVYITPDEKYPQ 493
Cdd:COG4287 389 LKLKEGGAVSVTVTYPKKGWQAFFVELTYKDGngpYTVSTRVYVLPDDKVPT 440
 
Name Accession Description Interval E-value
PqaA COG4287
PhoPQ-activated pathogenicity-related protein [General function prediction only];
53-493 0e+00

PhoPQ-activated pathogenicity-related protein [General function prediction only];


Pssm-ID: 443428  Cd Length: 440  Bit Score: 534.90  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16764889  53 NSPECdlshVLPDYREQiSGTPLKYTLINTAPLAQVVVRHYELLSQHWSPddmvtpAQWRHNVDIYIPETAKEHHALVVV 132
Cdd:COG4287  18 VTPET----ALKDYVNN-RDPPLKWELKDTTTLGGVTVYELLLTSQKWRP------ITWKHQLTIFVPKEVLPDGALLFI 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16764889 133 NNGINYDKGVQITgKPGDFPQETLASISRDTNTIVISVSDIPNQYLTFQddkkpLKEDESVSRSWALFMEAPeqRKLMPL 212
Cdd:COG4287  87 TGGSNKPEQPNWP-PPGDFDPELLAAIARKTKAIVALLSQVPNQPLFGG-----LREDALIAYTWHQFLKDP--DYTWPL 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16764889 213 NIPMVTAISQAMRLAKKELTQ---WNINSFIITGISKRGWTTWLSAIADPDVEAIVPFAIDLLDIDASLEHIYQSYGGnW 289
Cdd:COG4287 159 LFPMVKSAVRAMDAVQEFLKQelgKEIKRFVVTGASKRGWTTWLTAAADPRVKAIAPMVIDVLNMPASLEHQYKVYGG-Y 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16764889 290 PITFYPYYQQGIDEKIKSPAFTQLRQIIDPLRYLNtiyqpRLAIPKYIINASGDDFFVPDNTRFYYSKLPGVKSLRIVPN 369
Cdd:COG4287 238 SIAIEDYVKLGIPQQLGTPAGKALMQMVDPYSYRA-----RLTMPKYIVNGSNDDYWVPDAIKHYYDDLPGEKALRYVPN 312

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16764889 370 MNHYSINQF-AEGSLVPFINRFQSKKTLPQLIDLIHHH----LLTVYFSEAPVKVVRWTANNpNARDFRyacGIRYQPLT 444
Cdd:COG4287 313 AGHGLGDGKqAVEALSAFFGRTLQGRPLPQVSWKLDETgkgaRLTVASSEAPVKAKLWTATS-EDRDFR---GVRWTSRP 388

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|..
gi 16764889 445 IDSPVNNKISITLNEPKTGWEATYIEATFNDG---YVATSQVYITPDEKYPQ 493
Cdd:COG4287 389 LKLKEGGAVSVTVTYPKKGWQAFFVELTYKDGngpYTVSTRVYVLPDDKVPT 440
PhoPQ_related pfam10142
PhoPQ-activated pathogenicity-related protein; Members of this family of bacterial proteins ...
 63-433 0e+00

PhoPQ-activated pathogenicity-related protein; Members of this family of bacterial proteins are involved in the virulence of some pathogenic proteobacteria.


Pssm-ID: 401951  Cd Length: 366  Bit Score: 524.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16764889    63 LPDYREQiSGTPLKYTLINTAPLAQVVVRHYELLSQHWSPDDMVTPAQWRHNVDIYIP-ETAKEHHALVVVNNGINydkg 141
Cdd:pfam10142   1 LADYVEK-PDPPYKYTLTATYETAGVTIYILELTSQTWSPDQLVDPSLWKHWVTIYVPdDLALPETALLIISGGSN---- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16764889   142 VQITGKPGDFPQETLASISRDTNTIVISVSDIPNQYLTFQDDKKPLKEDESVSRSWALFMEaPEQRKLMPLNIPMVTAIS 221
Cdd:pfam10142  76 GNWKTPPPDSEPETLAEIARQTGTVVAELSDVPNQPLTFDGDGRPRREDALVAYTWRKFLE-PTQDPTWPLLLPMTKAAV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16764889   222 QAMRLAKKELTQW--NINSFIITGISKRGWTTWLSAIADPDVEAIVPFAIDLLDIDASLEHIYQSYGgNWPITFYPYYQQ 299
Cdd:pfam10142 155 RAMDLAQEFLKTLgyKIEKFVVTGASKRGWTTWLTAAVDKRVKAIAPMVIDILNMRKQLKHQYKSYG-NWSEALNDYVAE 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16764889   300 GIDEKIKSPAFTQLRQIIDPLRYLntiyqPRLAIPKYIINASGDDFFVPDNTRFYYSKLPGVKSLRIVPNMNHYSINQFA 379
Cdd:pfam10142 234 GIDDMLGTPAFDELLKIVDPYSYL-----QRLTMPKYIINASGDDFFVPDSTQFYFDDLPGEKYLRYVPNTSHGLINQQV 308

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 16764889   380 EGSLVPFINRFQSKKTLPQLIDLIHHHL----LTVYFSEAPVKVVRWTANNPNARDFR 433
Cdd:pfam10142 309 VESLVPFFKRVQAGRPLPELSWSIEGSAgtisVKVRSSEAPVKVKLWTATNPSARDFR 366
 
Name Accession Description Interval E-value
PqaA COG4287
PhoPQ-activated pathogenicity-related protein [General function prediction only];
53-493 0e+00

PhoPQ-activated pathogenicity-related protein [General function prediction only];


Pssm-ID: 443428  Cd Length: 440  Bit Score: 534.90  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16764889  53 NSPECdlshVLPDYREQiSGTPLKYTLINTAPLAQVVVRHYELLSQHWSPddmvtpAQWRHNVDIYIPETAKEHHALVVV 132
Cdd:COG4287  18 VTPET----ALKDYVNN-RDPPLKWELKDTTTLGGVTVYELLLTSQKWRP------ITWKHQLTIFVPKEVLPDGALLFI 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16764889 133 NNGINYDKGVQITgKPGDFPQETLASISRDTNTIVISVSDIPNQYLTFQddkkpLKEDESVSRSWALFMEAPeqRKLMPL 212
Cdd:COG4287  87 TGGSNKPEQPNWP-PPGDFDPELLAAIARKTKAIVALLSQVPNQPLFGG-----LREDALIAYTWHQFLKDP--DYTWPL 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16764889 213 NIPMVTAISQAMRLAKKELTQ---WNINSFIITGISKRGWTTWLSAIADPDVEAIVPFAIDLLDIDASLEHIYQSYGGnW 289
Cdd:COG4287 159 LFPMVKSAVRAMDAVQEFLKQelgKEIKRFVVTGASKRGWTTWLTAAADPRVKAIAPMVIDVLNMPASLEHQYKVYGG-Y 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16764889 290 PITFYPYYQQGIDEKIKSPAFTQLRQIIDPLRYLNtiyqpRLAIPKYIINASGDDFFVPDNTRFYYSKLPGVKSLRIVPN 369
Cdd:COG4287 238 SIAIEDYVKLGIPQQLGTPAGKALMQMVDPYSYRA-----RLTMPKYIVNGSNDDYWVPDAIKHYYDDLPGEKALRYVPN 312

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16764889 370 MNHYSINQF-AEGSLVPFINRFQSKKTLPQLIDLIHHH----LLTVYFSEAPVKVVRWTANNpNARDFRyacGIRYQPLT 444
Cdd:COG4287 313 AGHGLGDGKqAVEALSAFFGRTLQGRPLPQVSWKLDETgkgaRLTVASSEAPVKAKLWTATS-EDRDFR---GVRWTSRP 388

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|..
gi 16764889 445 IDSPVNNKISITLNEPKTGWEATYIEATFNDG---YVATSQVYITPDEKYPQ 493
Cdd:COG4287 389 LKLKEGGAVSVTVTYPKKGWQAFFVELTYKDGngpYTVSTRVYVLPDDKVPT 440
PhoPQ_related pfam10142
PhoPQ-activated pathogenicity-related protein; Members of this family of bacterial proteins ...
 63-433 0e+00

PhoPQ-activated pathogenicity-related protein; Members of this family of bacterial proteins are involved in the virulence of some pathogenic proteobacteria.


Pssm-ID: 401951  Cd Length: 366  Bit Score: 524.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16764889    63 LPDYREQiSGTPLKYTLINTAPLAQVVVRHYELLSQHWSPDDMVTPAQWRHNVDIYIP-ETAKEHHALVVVNNGINydkg 141
Cdd:pfam10142   1 LADYVEK-PDPPYKYTLTATYETAGVTIYILELTSQTWSPDQLVDPSLWKHWVTIYVPdDLALPETALLIISGGSN---- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16764889   142 VQITGKPGDFPQETLASISRDTNTIVISVSDIPNQYLTFQDDKKPLKEDESVSRSWALFMEaPEQRKLMPLNIPMVTAIS 221
Cdd:pfam10142  76 GNWKTPPPDSEPETLAEIARQTGTVVAELSDVPNQPLTFDGDGRPRREDALVAYTWRKFLE-PTQDPTWPLLLPMTKAAV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16764889   222 QAMRLAKKELTQW--NINSFIITGISKRGWTTWLSAIADPDVEAIVPFAIDLLDIDASLEHIYQSYGgNWPITFYPYYQQ 299
Cdd:pfam10142 155 RAMDLAQEFLKTLgyKIEKFVVTGASKRGWTTWLTAAVDKRVKAIAPMVIDILNMRKQLKHQYKSYG-NWSEALNDYVAE 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16764889   300 GIDEKIKSPAFTQLRQIIDPLRYLntiyqPRLAIPKYIINASGDDFFVPDNTRFYYSKLPGVKSLRIVPNMNHYSINQFA 379
Cdd:pfam10142 234 GIDDMLGTPAFDELLKIVDPYSYL-----QRLTMPKYIINASGDDFFVPDSTQFYFDDLPGEKYLRYVPNTSHGLINQQV 308

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 16764889   380 EGSLVPFINRFQSKKTLPQLIDLIHHHL----LTVYFSEAPVKVVRWTANNPNARDFR 433
Cdd:pfam10142 309 VESLVPFFKRVQAGRPLPELSWSIEGSAgtisVKVRSSEAPVKVKLWTATNPSARDFR 366
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 243-373 1.85e-03

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 40.28  E-value: 1.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16764889 243 GISKRGWTTWLSAIADPDVEAIV---PFAiDLLDIDAslEHIYQSYGGNWPITFYpyyqqgidekikSPAFTQ---LRQI 316
Cdd:COG1073 115 GISLGGGYALNAAATDPRVKAVIldsPFT-SLEDLAA--QRAKEARGAYLPGVPY------------LPNVRLaslLNDE 179

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 16764889 317 IDPLRYLNTIYQPRLAIpkyiinASGDDFFVP-DNTRFYYSKLPGVKSLRIVPNMNHY 373
Cdd:COG1073 180 FDPLAKIEKISRPLLFI------HGEKDEAVPfYMSEDLYEAAAEPKELLIVPGAGHV 231
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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