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Conserved domains on  [gi|16765741|ref|NP_461356|]
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MFS superfamily xanthosine permease [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]

Protein Classification

nucleoside permease( domain architecture ID 10017491)

nucleoside permease is a nucleoside:H(+) symporter (NHS) family major facilitator superfamily (MFS) transporter that facilitates the transport of nucleosides, similar to Escherichia coli nucleoside permease NupG and xanthosine permease XapB

CATH:  1.20.1250.20
Gene Ontology:  GO:0015506|GO:0015858|GO:0022857|GO:0055085
PubMed:  18537473|23403214|26758938|26098515
SCOP:  3000310
TCDB:  2.A.1.10

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A0110 TIGR00889
nucleoside transporter; This family of proteins transports nucleosides at a high affinity. The ...
 1-418 0e+00

nucleoside transporter; This family of proteins transports nucleosides at a high affinity. The transport mechanism is driven by proton motive force. This family includes nucleoside permease NupG and xanthosine permease from E.Coli. [Transport and binding proteins, Nucleosides, purines and pyrimidines]


:

Pssm-ID: 129967 [Multi-domain]  Cd Length: 418  Bit Score: 548.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741     1 MGITSRLKVMSFLQYFIWGSWLVTLGSYMINTLDFTGANVGMVYSSKGLAAIIMPGIMGIIADKWLRAERAYMLCHLVCA 80
Cdd:TIGR00889   1 MKTTAKLKFMSFLQWFIWGSWLVTLGSYMSKTLHFSGAEIGWVYSSTGIAAILMPILVGIIADKWLSAQKVYAVCHFAGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741    81 GALLYATTVTDPQTMFWVMLVNAMAYMPTIALSNSVSYSCLAKAGQDPVTSFPPVRVFGTIGFIVAMWTVSLMGLELSSA 160
Cdd:TIGR00889  81 LLLFFAAQVTTPAGMFPVLLANSLAYMPTIALTNSISYANLPQAGLDVVTDFPPIRVMGTIGFIAAMWAVSLLDIELSNI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741   161 QLYIASGASLLLALYALTLPKIPVAEKKANTTLASKLGLDAFVLFKNPRMAIFFLFAMMLGAVLQITNVFGNPFLHDFAR 240
Cdd:TIGR00889 161 QLYITAGSSALLGVFALTLPDIPVAKSTAKMSIKVMLGLDAFILFKNKRMAIFFFFSMLLGAPLQITNIFGNGFLHEFGR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741   241 NPEFADSFVVKYPSILLSVSQMAEVGFILTIPFFLKRFGIKTVMLMSMLAWTLRFGFFAFGDPSPFGFVLLLLSMIVYGC 320
Cdd:TIGR00889 241 NPEFADSFVVKNASIWMSLSQFSEIFFILTIPFFLKRFGIKKVMLLSLVAWALRFGFFAYGDPEYFGYALLFLSMIVYGC 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741   321 AFDFFNISGSVFVEQEVDSSIRASAQGLFMTMVNGVGAWIGSLLSGMAVDYFSIDGVKDWQTIWLVFAAYALALAVIFAL 400
Cdd:TIGR00889 321 AFDFFNISGSVFVEKEVPVHIRASAQGLFTLMCNGFGSLLGYILSGVMVEKMFAYGTFDWQTMWLFFAGYIAILAVLFMI 400

                         410
                  ....*....|....*...
gi 16765741   401 FFKYQHHPEKLSTKSLAH 418
Cdd:TIGR00889 401 FFKYSHNAIKVDDRDVAH 418
 
Name Accession Description Interval E-value
2A0110 TIGR00889
nucleoside transporter; This family of proteins transports nucleosides at a high affinity. The ...
 1-418 0e+00

nucleoside transporter; This family of proteins transports nucleosides at a high affinity. The transport mechanism is driven by proton motive force. This family includes nucleoside permease NupG and xanthosine permease from E.Coli. [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 129967 [Multi-domain]  Cd Length: 418  Bit Score: 548.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741     1 MGITSRLKVMSFLQYFIWGSWLVTLGSYMINTLDFTGANVGMVYSSKGLAAIIMPGIMGIIADKWLRAERAYMLCHLVCA 80
Cdd:TIGR00889   1 MKTTAKLKFMSFLQWFIWGSWLVTLGSYMSKTLHFSGAEIGWVYSSTGIAAILMPILVGIIADKWLSAQKVYAVCHFAGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741    81 GALLYATTVTDPQTMFWVMLVNAMAYMPTIALSNSVSYSCLAKAGQDPVTSFPPVRVFGTIGFIVAMWTVSLMGLELSSA 160
Cdd:TIGR00889  81 LLLFFAAQVTTPAGMFPVLLANSLAYMPTIALTNSISYANLPQAGLDVVTDFPPIRVMGTIGFIAAMWAVSLLDIELSNI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741   161 QLYIASGASLLLALYALTLPKIPVAEKKANTTLASKLGLDAFVLFKNPRMAIFFLFAMMLGAVLQITNVFGNPFLHDFAR 240
Cdd:TIGR00889 161 QLYITAGSSALLGVFALTLPDIPVAKSTAKMSIKVMLGLDAFILFKNKRMAIFFFFSMLLGAPLQITNIFGNGFLHEFGR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741   241 NPEFADSFVVKYPSILLSVSQMAEVGFILTIPFFLKRFGIKTVMLMSMLAWTLRFGFFAFGDPSPFGFVLLLLSMIVYGC 320
Cdd:TIGR00889 241 NPEFADSFVVKNASIWMSLSQFSEIFFILTIPFFLKRFGIKKVMLLSLVAWALRFGFFAYGDPEYFGYALLFLSMIVYGC 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741   321 AFDFFNISGSVFVEQEVDSSIRASAQGLFMTMVNGVGAWIGSLLSGMAVDYFSIDGVKDWQTIWLVFAAYALALAVIFAL 400
Cdd:TIGR00889 321 AFDFFNISGSVFVEKEVPVHIRASAQGLFTLMCNGFGSLLGYILSGVMVEKMFAYGTFDWQTMWLFFAGYIAILAVLFMI 400

                         410
                  ....*....|....*...
gi 16765741   401 FFKYQHHPEKLSTKSLAH 418
Cdd:TIGR00889 401 FFKYSHNAIKVDDRDVAH 418
MFS_NHS cd06177
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The ...
 6-403 1.39e-175

Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The prototypical members of the Nucleoside:H(+) symporter (NHS) family are Escherichia coli nucleoside permease NupG and xanthosine permease. Nucleoside:H(+) symporters are proton-driven transporters that facilitate the import of nucleosides across the cytoplasmic membrane. NupG is a broad-specificity transporter of purine and pyrimidine nucleosides. Xanthosine permease is involved in the uptake of xanthosine and other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine. The NHS family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340866 [Multi-domain]  Cd Length: 386  Bit Score: 495.23  E-value: 1.39e-175
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741   6 RLKVMSFLQYFIWGSWLVTLGSYMINTLDFTGANVGMVYSSKGLAAIIMPGIMGIIADKWLRAERAYMLCHLVCAGALLY 85
Cdd:cd06177   1 RLSVMMFLQFFIWGAWLVTLGGYMGSTLGFTGAQIGAVYSTTGIAAIIMPFFLGIIADRFFAAEKVLAVLHLIGAAALFY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741  86 ATTVTDPQTMFWVMLVNAMAYMPTIALSNSVSYSCLakagQDPVTSFPPVRVFGTIGFIVAMWTVSLMGLELSSAQLYIA 165
Cdd:cd06177  81 AATVTDFSVFFWVMLLYSLCYMPTLALTNSIAFSNL----EDPVKDFPPIRVWGTIGWIAAGWPVGFLGWEASNLQFYIA 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 166 SGASLLLALYALTLPKIPVAEKKANTTLASKLGLDAFVLFKNPRMAIFFLFAMMLGAVLQITNVFGNPFLHDFARNpefa 245
Cdd:cd06177 157 AGASLLLGLYSLTLPHTPPKKAGKGVSKRSLLGLDAFVLLKNPFFAVFFIFSFLLGAPLQFYYTFANPFLNDFGMI---- 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 246 dsfvVKYPSILLSVSQMAEVGFILTIPFFLKRFGIKTVMLMSMLAWTLRFGFFAFGDPSPfGFVLLLLSMIVYGCAFDFF 325
Cdd:cd06177 233 ----VKNPAGIMSLGQISEILFMLAIPFFLKRLGIKKVMLIGMLAWVLRFGLFAYGDPSP-GVWMLVLSIILHGVCYDFF 307

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16765741 326 NISGSVFVEQEVDSSIRASAQGLFMTMVNGVGAWIGSLLSGMAVDYFSI-DGVKDWQTIWLVFAAYALALAVIFALFFK 403
Cdd:cd06177 308 FVTGYIYVDKKAPKDIRASAQGLFMLMTNGVGALVGSILSGKVVDKFTTvEGTKDWQTIWLVPAIYALVLAILFALFFR 386
Nuc_H_symport pfam03825
Nucleoside H+ symporter;
1-406 1.17e-167

Nucleoside H+ symporter;


Pssm-ID: 461066 [Multi-domain]  Cd Length: 399  Bit Score: 475.80  E-value: 1.17e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741     1 MGITSRLKVMSFLQYFIWGSWLVTLGSYMINTLdFTGANVGMVYSSKGLAAIIMPGIMGIIADKWLRAERAYMLCHLVCA 80
Cdd:pfam03825   1 MNTKLRLKVMMFLQFFIWGAWLVTLGSYMFVTG-FDGASIGAVYSSLGIAAIFMPALLGIIADRWFSAERVLAVCHLIGA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741    81 GALLYATTVTDPQTMFWVMLVNAMAYMPTIALSNSVSYSCLakagQDPVTSFPPVRVFGTIGFIVA-----MWTVSLMGL 155
Cdd:pfam03825  80 ITLFMAAQVTTFEAFFLVILVNSLAYMPTLALTNSIAFANL----QDPVTDFPPIRVWGTIGWIMAswpfvMWVVSLAGF 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741   156 ELSSAQLYIASGASLLLALYALTLPKIPvAEKKANTTLASKLGLDAFVLFKNPRMAIFFLFAMMLGAVLQITNVFGNPFL 235
Cdd:pfam03825 156 ELSHMQLLIAAGLSALLVLFALTLPHTP-AKQKANQSWTTLLGLDAFALLKNKRMAVFFIFSFLLGAELQIYNVFANTFL 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741   236 HDFARnpefadsFVVKYPSILLSVSQMAEVGFILTIPFFLKRFGIKTVMLMSMLAWTLRFGFFAFG-DPSPFGFVLLLLS 314
Cdd:pfam03825 235 TSFDK-------FIVKHASIIMSLGQISEILFMLTLPFFLKRFGIKNVMLIGIVAWALRFAFFAYGaDPTPFGTALLLLS 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741   315 MIVYGCAFDFFNISGSVFVEQEVDSSIRASAQGLFMTMVNGVGAWIGSLLSGMAVDYFSIDGVKDWQTIWLVFAAYALAL 394
Cdd:pfam03825 308 MIVHGVAYDFFNITGYIFVDKEVPPAIRASAQGLFLLMTNGFGCILGSILSGMVVEMFTQDGITDWQTVWLVFAGMALVL 387

                         410
                  ....*....|..
gi 16765741   395 AVIFALFFKYQH 406
Cdd:pfam03825 388 AVLFMAFFRYKH 399
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
184-404 8.61e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 50.67  E-value: 8.61e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 184 VAEKKANTTLASKLGLDAFVLFKNPRMAIFFLFAMMLGAVLQITNVFGNPFLHDFARNPEfadsfvvKYPSILLSVSQMA 263
Cdd:COG2211 204 TKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSA-------ALVGLLLALYFLA 276

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 264 EVGFILTIPFFLKRFGIKTVMLMSMLAWTLRFGFFAFGDPSPfgFVLLLLSMIVYGCAFDFFNISGSVFV-----EQEVD 338
Cdd:COG2211 277 ALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGN--LWLLLVLAALAGIGLGAILVLPWAMLadvvdYDEWK 354

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16765741 339 SSIRASAQGL-FMTMVNGVGAWIGSLLSGMAVDYFSIDGVKDW-----QTIWLVFAAYALALAVI-FALFFKY 404
Cdd:COG2211 355 TGRRREGLYFgIFTFAIKLGQALAGALAGLLLALFGYVAGAAQspsalTGIRLLFFLLPAVLLLLaALLLLFY 427
 
Name Accession Description Interval E-value
2A0110 TIGR00889
nucleoside transporter; This family of proteins transports nucleosides at a high affinity. The ...
 1-418 0e+00

nucleoside transporter; This family of proteins transports nucleosides at a high affinity. The transport mechanism is driven by proton motive force. This family includes nucleoside permease NupG and xanthosine permease from E.Coli. [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 129967 [Multi-domain]  Cd Length: 418  Bit Score: 548.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741     1 MGITSRLKVMSFLQYFIWGSWLVTLGSYMINTLDFTGANVGMVYSSKGLAAIIMPGIMGIIADKWLRAERAYMLCHLVCA 80
Cdd:TIGR00889   1 MKTTAKLKFMSFLQWFIWGSWLVTLGSYMSKTLHFSGAEIGWVYSSTGIAAILMPILVGIIADKWLSAQKVYAVCHFAGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741    81 GALLYATTVTDPQTMFWVMLVNAMAYMPTIALSNSVSYSCLAKAGQDPVTSFPPVRVFGTIGFIVAMWTVSLMGLELSSA 160
Cdd:TIGR00889  81 LLLFFAAQVTTPAGMFPVLLANSLAYMPTIALTNSISYANLPQAGLDVVTDFPPIRVMGTIGFIAAMWAVSLLDIELSNI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741   161 QLYIASGASLLLALYALTLPKIPVAEKKANTTLASKLGLDAFVLFKNPRMAIFFLFAMMLGAVLQITNVFGNPFLHDFAR 240
Cdd:TIGR00889 161 QLYITAGSSALLGVFALTLPDIPVAKSTAKMSIKVMLGLDAFILFKNKRMAIFFFFSMLLGAPLQITNIFGNGFLHEFGR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741   241 NPEFADSFVVKYPSILLSVSQMAEVGFILTIPFFLKRFGIKTVMLMSMLAWTLRFGFFAFGDPSPFGFVLLLLSMIVYGC 320
Cdd:TIGR00889 241 NPEFADSFVVKNASIWMSLSQFSEIFFILTIPFFLKRFGIKKVMLLSLVAWALRFGFFAYGDPEYFGYALLFLSMIVYGC 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741   321 AFDFFNISGSVFVEQEVDSSIRASAQGLFMTMVNGVGAWIGSLLSGMAVDYFSIDGVKDWQTIWLVFAAYALALAVIFAL 400
Cdd:TIGR00889 321 AFDFFNISGSVFVEKEVPVHIRASAQGLFTLMCNGFGSLLGYILSGVMVEKMFAYGTFDWQTMWLFFAGYIAILAVLFMI 400

                         410
                  ....*....|....*...
gi 16765741   401 FFKYQHHPEKLSTKSLAH 418
Cdd:TIGR00889 401 FFKYSHNAIKVDDRDVAH 418
MFS_NHS cd06177
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The ...
 6-403 1.39e-175

Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The prototypical members of the Nucleoside:H(+) symporter (NHS) family are Escherichia coli nucleoside permease NupG and xanthosine permease. Nucleoside:H(+) symporters are proton-driven transporters that facilitate the import of nucleosides across the cytoplasmic membrane. NupG is a broad-specificity transporter of purine and pyrimidine nucleosides. Xanthosine permease is involved in the uptake of xanthosine and other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine. The NHS family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340866 [Multi-domain]  Cd Length: 386  Bit Score: 495.23  E-value: 1.39e-175
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741   6 RLKVMSFLQYFIWGSWLVTLGSYMINTLDFTGANVGMVYSSKGLAAIIMPGIMGIIADKWLRAERAYMLCHLVCAGALLY 85
Cdd:cd06177   1 RLSVMMFLQFFIWGAWLVTLGGYMGSTLGFTGAQIGAVYSTTGIAAIIMPFFLGIIADRFFAAEKVLAVLHLIGAAALFY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741  86 ATTVTDPQTMFWVMLVNAMAYMPTIALSNSVSYSCLakagQDPVTSFPPVRVFGTIGFIVAMWTVSLMGLELSSAQLYIA 165
Cdd:cd06177  81 AATVTDFSVFFWVMLLYSLCYMPTLALTNSIAFSNL----EDPVKDFPPIRVWGTIGWIAAGWPVGFLGWEASNLQFYIA 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 166 SGASLLLALYALTLPKIPVAEKKANTTLASKLGLDAFVLFKNPRMAIFFLFAMMLGAVLQITNVFGNPFLHDFARNpefa 245
Cdd:cd06177 157 AGASLLLGLYSLTLPHTPPKKAGKGVSKRSLLGLDAFVLLKNPFFAVFFIFSFLLGAPLQFYYTFANPFLNDFGMI---- 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 246 dsfvVKYPSILLSVSQMAEVGFILTIPFFLKRFGIKTVMLMSMLAWTLRFGFFAFGDPSPfGFVLLLLSMIVYGCAFDFF 325
Cdd:cd06177 233 ----VKNPAGIMSLGQISEILFMLAIPFFLKRLGIKKVMLIGMLAWVLRFGLFAYGDPSP-GVWMLVLSIILHGVCYDFF 307

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16765741 326 NISGSVFVEQEVDSSIRASAQGLFMTMVNGVGAWIGSLLSGMAVDYFSI-DGVKDWQTIWLVFAAYALALAVIFALFFK 403
Cdd:cd06177 308 FVTGYIYVDKKAPKDIRASAQGLFMLMTNGVGALVGSILSGKVVDKFTTvEGTKDWQTIWLVPAIYALVLAILFALFFR 386
Nuc_H_symport pfam03825
Nucleoside H+ symporter;
1-406 1.17e-167

Nucleoside H+ symporter;


Pssm-ID: 461066 [Multi-domain]  Cd Length: 399  Bit Score: 475.80  E-value: 1.17e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741     1 MGITSRLKVMSFLQYFIWGSWLVTLGSYMINTLdFTGANVGMVYSSKGLAAIIMPGIMGIIADKWLRAERAYMLCHLVCA 80
Cdd:pfam03825   1 MNTKLRLKVMMFLQFFIWGAWLVTLGSYMFVTG-FDGASIGAVYSSLGIAAIFMPALLGIIADRWFSAERVLAVCHLIGA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741    81 GALLYATTVTDPQTMFWVMLVNAMAYMPTIALSNSVSYSCLakagQDPVTSFPPVRVFGTIGFIVA-----MWTVSLMGL 155
Cdd:pfam03825  80 ITLFMAAQVTTFEAFFLVILVNSLAYMPTLALTNSIAFANL----QDPVTDFPPIRVWGTIGWIMAswpfvMWVVSLAGF 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741   156 ELSSAQLYIASGASLLLALYALTLPKIPvAEKKANTTLASKLGLDAFVLFKNPRMAIFFLFAMMLGAVLQITNVFGNPFL 235
Cdd:pfam03825 156 ELSHMQLLIAAGLSALLVLFALTLPHTP-AKQKANQSWTTLLGLDAFALLKNKRMAVFFIFSFLLGAELQIYNVFANTFL 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741   236 HDFARnpefadsFVVKYPSILLSVSQMAEVGFILTIPFFLKRFGIKTVMLMSMLAWTLRFGFFAFG-DPSPFGFVLLLLS 314
Cdd:pfam03825 235 TSFDK-------FIVKHASIIMSLGQISEILFMLTLPFFLKRFGIKNVMLIGIVAWALRFAFFAYGaDPTPFGTALLLLS 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741   315 MIVYGCAFDFFNISGSVFVEQEVDSSIRASAQGLFMTMVNGVGAWIGSLLSGMAVDYFSIDGVKDWQTIWLVFAAYALAL 394
Cdd:pfam03825 308 MIVHGVAYDFFNITGYIFVDKEVPPAIRASAQGLFLLMTNGFGCILGSILSGMVVEMFTQDGITDWQTVWLVFAGMALVL 387

                         410
                  ....*....|..
gi 16765741   395 AVIFALFFKYQH 406
Cdd:pfam03825 388 AVLFMAFFRYKH 399
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 6-401 4.35e-21

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 93.80  E-value: 4.35e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741   6 RLKVMSFLQYFIWGSWLVTLGSYMINtLDFTGANVGMVYSSKGLAAIIMPGIMGIIADKWlRAERAYMLCHLVCA--GAL 83
Cdd:cd17335   1 RLKLFYFFFFAALGSLLPFLSVYLKQ-LGLSPTQIGILIGIRPFVRFLSAPLWGALADRF-GKRKALLLLSLLAAvlFFL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741  84 LYATTVTDPQTMFWVMLVNAMAYMPTIALSNSVSYSCLAKAGQDpvtsFPPVRVFGTIGFIVAMWtvsLMGLELSSAQLY 163
Cdd:cd17335  79 SLFFVAQIFWLLLLLVILGAFFSAPVVPLVDSITLQYLGEERER----YGKQRLWGSIGFGIAAL---LVGILIDRSSTY 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 164 IAS-----GASLLLALYALTLPKIPVAEKKANTTLASKlglDAFVLFKNPRMAIFFLFAMMLGAVLQITNVFGNPFLHDF 238
Cdd:cd17335 152 KNYtiafyVFAVLMLLALLLALKFPFRPKHPEPNENTG---GLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDL 228

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 239 ARNPEFAdsfvvkypSILLSVSQMAEVGFILTIPFFLKRFGIKTVMLMSMLAWTLRFGFFAFGDPSPFGFVLLLLSmivy 318
Cdd:cd17335 229 GGSKTLI--------GLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLH---- 296

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 319 GCAFDFFNISGSVFVEQEVDSSIRASAQGLFMTMVNGVGAWIGSLLSGMAVDYFSIdgvkdwQTIWLVFAAYALALAVIF 398
Cdd:cd17335 297 GLTFALVWAAAVSYASAAAPPGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGA------RTTFRFFAIAALAGLLAF 370


                ...
gi 16765741 399 ALF 401
Cdd:cd17335 371 FLI 373
MFS_1_like pfam12832
MFS_1 like family; This family contains proteins related to the MFS superfamily.
 6-373 2.41e-14

MFS_1 like family; This family contains proteins related to the MFS superfamily.


Pssm-ID: 432817 [Multi-domain]  Cd Length: 362  Bit Score: 73.82  E-value: 2.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741     6 RLKVMSFLQYFIWGSWLVTLGSYMiNTLDFTGANVGMVYSSKGLAAIIMPGIMGIIADKWLRAE---RAYMLCHLVCAGA 82
Cdd:pfam12832   3 RLKGFYFFYFAALGCLLPYWGLYL-RSIGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKavvRLASILAAVLFLS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741    83 LLYATTVTDPQTMFWVMLVNAMAYMPTIALSNSVSYSCLAKAGQDpvtsFPPVRVFGTIGFIVAMWTVSLMGLELSSAQL 162
Cdd:pfam12832  82 VLFIPISLTFWWLALLVVLFSFFWNAILPQFEVATLQHLGEKRKD----YGRQRLWGSVGFALSVFGLGALFDHYSVGLL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741   163 YIASGASLLLALYALTLPKIPVAEKKANTTLASKLGLdaFVLFKNPRMAIFFLFAMMLGAVLQITNVFGNPFLHDFARNP 242
Cdd:pfam12832 158 PSVLFYLFAALMLLSLLLPLAPPEMEYESKGGSKAVF--WNLLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYLENLGASN 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741   243 EFAdsfvvkypSILLSVSQMAEVGFILTIPFFLKRFGIKTVMLMSMLAWTLRFGFFAFGDPSPfgfVLLLLSMIVYGCAF 322
Cdd:pfam12832 236 TLL--------GALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLYAFFVENP---WLVLPIQFLHAISF 304

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 16765741   323 DFFNISGSVFVEQEVDSSIRASAQGLFMTMVNGVGAWIGSLLSGMAVDYFS 373
Cdd:pfam12832 305 GLTHAAAIEYVRRIFPGSLQGTGQALYSGLYFGLGGALGSLIGGQLWDLFG 355
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 7-398 2.76e-11

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 64.76  E-value: 2.76e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741   7 LKVMSFLQYFIWGSWLVTLGSYMINtLDFTGANVGMVYSSKGLAAIIMPGIMGIIADKWLRaERAYMLCHLVCAGALLYA 86
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALLQS-FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGR-RPVLLLGLLLFALGALLF 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741  87 TTVTDPQTMFWVMLVNAMAYMPTIALSNSVSYSCLAKAGQDPVTSFppVRVFGTIGFIVAMWTVSLMGLELSS---AQLY 163
Cdd:cd06174  79 AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGL--LQAFGSVGGILGPLLGGILASSLGFgwrAVFL 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 164 IASGASLLLALYALTLPKIPVAEKKANTTLASK--LGLDAFVLFKNPRMAIFFLFAMMLGAVLQITNVFGNPFLHDFARn 241
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESARAKNEEASSksVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGG- 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 242 pefadsFVVKYPSILLSVSQMAEVGFILTIPFFLKR-FGIKTVMLMSMLAWTLRFGFFAFGDPSPFGFVLlllsMIVYGC 320
Cdd:cd06174 236 ------LSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLL----LLLLGF 305

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16765741 321 AFDFFNISGSVFVEQEVDSSIRASAQGLFMTMVNGVGAWIGSLLSGMAVDYFSidgvkdWQTIWLVFAAYALALAVIF 398
Cdd:cd06174 306 GLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFG------LTGAFLVLAVLLLLAAILL 377
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
184-404 8.61e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 50.67  E-value: 8.61e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 184 VAEKKANTTLASKLGLDAFVLFKNPRMAIFFLFAMMLGAVLQITNVFGNPFLHDFARNPEfadsfvvKYPSILLSVSQMA 263
Cdd:COG2211 204 TKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSA-------ALVGLLLALYFLA 276

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 264 EVGFILTIPFFLKRFGIKTVMLMSMLAWTLRFGFFAFGDPSPfgFVLLLLSMIVYGCAFDFFNISGSVFV-----EQEVD 338
Cdd:COG2211 277 ALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGN--LWLLLVLAALAGIGLGAILVLPWAMLadvvdYDEWK 354

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16765741 339 SSIRASAQGL-FMTMVNGVGAWIGSLLSGMAVDYFSIDGVKDW-----QTIWLVFAAYALALAVI-FALFFKY 404
Cdd:COG2211 355 TGRRREGLYFgIFTFAIKLGQALAGALAGLLLALFGYVAGAAQspsalTGIRLLFFLLPAVLLLLaALLLLFY 427
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 163-402 2.30e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 46.03  E-value: 2.30e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 163 YIASGASLLLALYALTLPKIPVAEKKANTTLASKLGLDAFVLFKNPRMAIFFLFAMMLGAVLQITNVFGNPFLHDFARnp 242
Cdd:cd17325 154 LVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGG-- 231

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 243 efADSFVVkypSILLSVsqmAEVGFILTIPFFLK---RFGIKTVMLMSMLAWTLRFGFFAFGDpspfGFVLLLLSMIVYG 319
Cdd:cd17325 232 --LSPAQI---GLLFGA---QGLASALSQPPAGKlsdRIGRKPLILIGLLLSAVALLLLPLAT----SFWLLLLLLALLG 299

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 320 CAFDFFNISGSVFVEQEVDSSIRASAQGLFMTMVNgVGAWIGSLLSGMAVDYFSidgvkdWQTIWLVFAAYALALAVIFA 399
Cdd:cd17325 300 LGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFS-LGMVLGPLLGGFLYDAFG------FATPFLAAAALLLLAAVLFL 372


                ...
gi 16765741 400 LFF 402
Cdd:cd17325 373 LLR 375
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 277-398 3.76e-05

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 45.61  E-value: 3.76e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 277 RFGIKTVMLMSMLAWTLRFGFFAFGDPSPFgfvlLLLSMIVYGCAFDFFNISGSVFVEQEVDSSIRASAQGLFMTMVnGV 356
Cdd:cd17370 260 RIGRKKLLILGYLSLALAYLGFALGSSLWL----LLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVV-GI 334

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 16765741 357 GAWIGSLLSGMAVDYFSIdgvkdWQTIWLVFAAYALALAVIF 398
Cdd:cd17370 335 GWLLASLIAGYLWDLISP-----SAAFLFSAVLALIALLLLL 371
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
205-410 6.13e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 44.96  E-value: 6.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 205 FKNPRMAIFFLFAMMLGAVLQITNVFGNPFLHDFARNPEFAdsfvvkypSILLSVSQMAEVGFILTIPFFLKRFGIKTVM 284
Cdd:COG2814   7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQA--------GLVVTAYLLGAALGAPLAGRLADRFGRRRVL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 285 LMSMLAWTLRFGFFAFGDpspfGFVLLLLSMIVYGCAFDFFNISGSVFVEQEVDSSIRASAQGLFMtMVNGVGAWIGSLL 364
Cdd:COG2814  79 LLGLLLFALGSLLCALAP----SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLG-AGLGLGPALGPLL 153

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 16765741 365 SGMAVDYFSidgvkdWQTIWLVFAAYALALAVIFALFFKYQHHPEK 410
Cdd:COG2814 154 GGLLADLFG------WRWVFLVNAVLALLALLLLLRLLPESRPAAR 193
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
205-401 6.73e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 44.84  E-value: 6.73e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 205 FKNPRMAIFFLFAMMlGAVLQITNVFGNPFLHDFARNPEFAdsfvvkypSILLSVSQMAEVGFILTIPFFLKRFGIKTVM 284
Cdd:COG0738   6 YRRALIAIYLLFFLW-GFATALWGPLIPALKDAFGLSDAQA--------GLLLFAFFLGYLLASLPAGRLIDRFGYKRGL 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 285 LMSMLAWTLRFGFFAFGDpspfGFVLLLLSMIVYGCAFDFFNISGSVFV---EQEVDSSIRASAQGLFmtmvnGVGAWIG 361
Cdd:COG0738  77 LLGLLLMALGLLLFALAP----SYPLLLLALFLLGLGLGLLDVAANPYVaalGPETAASRLNLLHAFF-----SLGALLG 147

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 16765741 362 SLLSGMAVdyfSIDGVKDWQTIWLVFAAYALALAVIFALF 401
Cdd:COG0738 148 PLLGGLLI---LLGLSLSWHLPYLILAVLLLLLALLFLRS 184
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 254-418 3.70e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 42.41  E-value: 3.70e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 254 SILLSVSQMAEVGFILTIPFFLKRFGIKTVMLMSMLAWTLRFGFFAFgdpsPFGFVLLLLSMIVYGCAFDFFNISGSVFV 333
Cdd:cd06174  34 GLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF----APSFWLLLLGRFLLGLGSGLIDPAVLALI 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 334 EQEVDSSIRASAQGLFMTMVnGVGAWIGSLLSGMAVDYFSIDgvkdWQTIWLVFAAYALALAVIFALFFKYQHHPEKLST 413
Cdd:cd06174 110 ADLFPERERGRALGLLQAFG-SVGGILGPLLGGILASSLGFG----WRAVFLIAAALALLAAILLLLVVPDPPESARAKN 184


                ....*
gi 16765741 414 KSLAH 418
Cdd:cd06174 185 EEASS 189
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
194-358 1.76e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 40.34  E-value: 1.76e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 194 ASKLGLDAFVLFKNPRMAIFFLFAMMLGAVLQITNVFGNPFLHDFARNPEFAdsfvvkyPSILLSVSQMAEVGFILTIPF 273
Cdd:COG2814 193 RARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASA-------AGLLLALFGLGGVLGALLAGR 265

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 274 FLKRFGIKTVMLMSMLAWTLRFGFFAFGDpspfGFVLLLLSMIVYGCAFDFFNISGSVFVEQEVDSSIRASAQGLFMTMV 353
Cdd:COG2814 266 LADRFGRRRLLLIGLLLLALGLLLLALAG----SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAF 341


                ....*
gi 16765741 354 NGVGA 358
Cdd:COG2814 342 FLGGP 346
MFS_1 pfam07690
Major Facilitator Superfamily;
254-418 1.78e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 40.09  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741   254 SILLSVSQMAEVGFILTIPFFLKRFGIKTVMLMSMLAWTLRFGFFAFGDPSPfgfvLLLLSMIVYGCAFDFFNISGSVFV 333
Cdd:pfam07690  35 GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLW----LLLVLRVLQGLGAGALFPAALALI 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741   334 EQEVDSSIRASAQGLFMTMvNGVGAWIGSLLSGMAVDYFSidgvkdWQTIWLVFAAYALALAVIFALFFKYQHHPEKLST 413
Cdd:pfam07690 111 ADWFPPEERGRALGLVSAG-FGLGAALGPLLGGLLASLFG------WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPA 183


                  ....*
gi 16765741   414 KSLAH 418
Cdd:pfam07690 184 EEARL 188
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 182-400 3.46e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 39.48  E-value: 3.46e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 182 IPVAEKKANTTLASKLGLDAFVLFKNPRMAIFFLFAMMLGAVLQITNVFGNPF-LHDFARNPEFADSFVVKYPSILLSVS 260
Cdd:cd17474 171 FLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFlLELLYGISPIIIGLLFAGWSVLLALG 250

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 261 QMAeVGFILTipfflKRFGIKTVMLMSMLAWTLRFGFFAFGDpspfGFVLLLLSMIVYGCAFDFFNISGSVFVEQEVDSS 340
Cdd:cd17474 251 SLF-VGRLLK-----KRFGARRILVIGLLLYALSLLLLGFVP----SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEE 320

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 341 IRASAQGLFmTMVNGVGAWIGSLLSGMAVDYFSIDGVkdwqtIWLVFAAYALALAVIFAL 400
Cdd:cd17474 321 ERGTASSLY-NFVRFLGQAVGPLLFGLLLEIFGLSAP-----FLVGAAIALAAAVLLALL 374
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 267-403 3.58e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 39.09  E-value: 3.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 267 FILTIP--FFLKRFGIKTVMLMSMLAWTLRFGFFAFGDpspfGFVLLLLSMIVYGCAFDFFNISGSVFVEQEVDSSIRAS 344
Cdd:cd17319  52 ALFQVPggWLLDRFGARKVLAVSMLLWSLFTALTGFAT----SLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGR 127

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 16765741 345 AQGLFMtMVNGVGAWIGSLLSGMAVDYFSidgvkdWQTIWLVFAAYALALAVIFALFFK 403
Cdd:cd17319 128 ATGLFN-SGAPLGAAIGPPLSGWLLLLFG------WRWAFIIEGLLGLLLAVLWWFYLR 179
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
277-397 3.63e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 39.08  E-value: 3.63e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 277 RFGIKTVMLMSMLAWTLRFGFFAFGDpspfGFVLLLLSMIVYGCAFDFFNISGSVFVEQEVDSSIRASAQGLFMTMVNgV 356
Cdd:COG2271  71 RFGRRRVLAIGLLLWGLATLLFGFAT----SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGP-L 145

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 16765741 357 GAWIGSLLSGMAVDYFsidgvkDWQTIWLVFAAYALALAVI 397
Cdd:COG2271 146 GGALAPPLLGWLLAAF------GWRAAFLILGLPGLLLALL 180
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 137-400 3.69e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 39.08  E-value: 3.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 137 VFGTIGF----IVAMWTVSLMGLELSSAQLYIASGASLLLALYALTLPKIPVAEKKANTTLASKLGLDAFVLfknprmAI 212
Cdd:cd17478 126 VGGNLGFalgpLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRAL------LL 199

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 213 FFLFAMMLGAVLQITNVFGNPFLHDFARNPEFAdsfvvkypSILLSVSQMAEVGFILTIPFFLKRFGIKTVMLMSMLAWT 292
Cdd:cd17478 200 LLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFA--------GLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAA 271

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 293 LRFGFFAFGDPSPFGFVLLLLSMIVygcafdFFNISGSVFVEQEVDSSIRASAQGLFMTMVNGVGAwIGSLLSGMAVDYF 372
Cdd:cd17478 272 PFLLLFLLTPGIWSYILLVLAGFLL------FASFPVTVVLAQELLPGNVGLASGLMMGLSFGLGG-IGAPVLGALADAF 344

                       250       260
                ....*....|....*....|....*...
gi 16765741 373 SIDGVkdwqtiwLVFAAYALALAVIFAL 400
Cdd:cd17478 345 GLESV-------LLILALLPLLGALLAF 365
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 269-401 5.65e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 38.75  E-value: 5.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16765741 269 LTIPFFLKRFGIKTVMLMSMLAWTLRFGFFAFgdpsPFGFVLLLLSMIVYGCAFDFFNISGSVFVEQEVDSSIRASAQGL 348
Cdd:cd06173 262 LLLGRLSKRRRRGRLLLIGALLLGLALLVLGL----SPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSV 337

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 16765741 349 FMTMVNGVGAwIGSLLSGMAVDYFSIdgvkdwQTIWLVFAAYALALAVIFALF 401
Cdd:cd06173 338 YNALNSGAMP-LGALLAGLLADALGL------SAVFLLAGALLLLAALLLLLL 383
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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