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Conserved domains on  [gi|386769627|ref|NP_476790|]
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wing blister, isoform G [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
153-398 4.27e-68

Laminin N-terminal (Domain VI);


:

Pssm-ID: 459653  Cd Length: 230  Bit Score: 230.16  E-value: 4.27e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627   153 LYPPLFNVVPRAQISVNATCGQNGAEEYCKQVG---AKPCGICNahSSDRAKQRSIQSLIssgsgsGSGSGFEEGWWQSP 229
Cdd:pfam00055    1 CYPAFGNLAFGREVSATSTCGLNGPERYCILSGlegGKKCFICD--SRDPHNSHPPSNLT------DSNNGTNETWWQSE 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627   230 TLQggRQFEYVTILLDLKQTFQIFSVWLKSAnSPRPASWILEKSLD-GINFEPWQYFglsDADCQRRWNLsgQNGKYVFQ 308
Cdd:pfam00055   73 TGV--IQYENVNLTLDLGKEFHFTYLILKFK-SPRPAAMVLERSTDfGKTWQPYQYF---ASDCRRTFGR--PSGPSRGI 144

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627   309 NDTEIICSTQFSKPGPLENGVLHASLLKNRPGAT--DQSPELMKFITTRYIRIRLQGMHSTAnqdnslDWLLDSPSLEKH 386
Cdd:pfam00055  145 KDDEVICTSEYSDISPLTGGEVIFSTLEGRPSANifDYSPELQDWLTATNIRIRLLRLHTLG------DELLDDPSVLRK 218

                          250
                   ....*....|..
gi 386769627   387 SFYSLSQLKVSA 398
Cdd:pfam00055  219 YYYAISDISVGG 230
Laminin_B pfam00052
Laminin B (Domain IV);
1486-1626 1.20e-28

Laminin B (Domain IV);


:

Pssm-ID: 459652  Cd Length: 136  Bit Score: 113.13  E-value: 1.20e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  1486 YFQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLERNilgQYPLVQLHAHSKLLLDFYEYEEF-EYSLNVTHRVPLHESFW 1564
Cdd:pfam00052    1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGGGSLN---SEPDVILEGNGLRLSYSSPDQPPpDPGQEQTYSVRLHEENW 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 386769627  1565 KyHHTSQAVDRNTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAAIYikGSTNLIAKGVE 1626
Cdd:pfam00052   78 R-DSDGAPVSREDFMMVLANLTAILIRATYSTGSGQVSLSNVSLDSAVP--GGSGPPASWVE 136
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2804-2944 4.18e-26

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 105.58  E-value: 4.18e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  2804 FRTLQPDCLLLLAAYPPeilGDYdakdikgnFSISLVDGQLHVWVNSGRSFIKMSSNSSQMNDGEFHVVHLIKTGRKLEL 2883
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGG---SDF--------LALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTL 69

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 386769627  2884 MVDDELQEIRNLNGNPTVVSLPRDaggLYIGGAPPhESYTPLAPTFVNLEGAIRDVVFNNR 2944
Cdd:pfam02210   70 SVDGQTVVSSLPPGESLLLNLNGP---LYLGGLPP-LLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2586-2753 3.05e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 98.26  E-value: 3.05e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627 2586 ARHFNGLGYAQLmktRPRPTRKNLFSVQMTFRTLDENALLFLAVDDKNNRSVSVTLSRGRIMFRIDYGdESKLEINTTKK 2665
Cdd:cd00110     1 GVSFSGSSYVRL---PTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLG-SGSLVLSSKTP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627 2666 YNVGQWIKIeaarefSAKRSTENGMLRVNNDRPISGAPTLPVNIHLLPDLsktvYYLGGVPPGFTSGTSKAPgadNPFLG 2745
Cdd:cd00110    77 LNDGQWHSV------SVERNGRSVTLSVDGERVVESGSPGGSALLNLDGP----LYLGGLPEDLKSPGLPVS---PGFVG 143


                  ....*...
gi 386769627 2746 CMKDVQVN 2753
Cdd:cd00110   144 CIRDLKVN 151
Laminin_B pfam00052
Laminin B (Domain IV);
660-813 4.72e-22

Laminin B (Domain IV);


:

Pssm-ID: 459652  Cd Length: 136  Bit Score: 94.26  E-value: 4.72e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627   660 YWQASLGYLGNRLTSYGSRLQLVLSWDviRGDRSGKPTTGPNVILVGkNGLKIAFGDESLDGLGINLN----VTLTEVGW 735
Cdd:pfam00052    1 YWSAPEQFLGNKLTSYGGYLTYTVRYE--PLPGGGSLNSEPDVILEG-NGLRLSYSSPDQPPPDPGQEqtysVRLHEENW 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386769627   736 YHVPptvvdiktrlrrteggdyhGESVTRSQFLSVLVSLDAVLIRAAFHTDQGETSLERAVIYSGGVELGGKSSSQVE 813
Cdd:pfam00052   78 RDSD-------------------GAPVSREDFMMVLANLTAILIRATYSTGSGQVSLSNVSLDSAVPGGSGPPASWVE 136
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1199-1247 2.79e-14

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 69.30  E-value: 2.79e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 386769627  1199 CRCDPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRC 1247
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1150-1197 1.14e-13

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 67.38  E-value: 1.14e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 386769627 1150 CHCSSVGSLSSDCDKRTGQCACLANVTGRRCDKCRPGHWNL-TAGEGCR 1197
Cdd:cd00055     2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLpSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1065-1105 2.82e-13

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 66.22  E-value: 2.82e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 386769627  1065 CNCDPLGSlVQDRCDPHTGQCHCKEGVMGAKCHECQDGYFG 1105
Cdd:pfam00053    1 CDCNPHGS-LSDTCDPETGQCLCKPGVTGRHCDRCKPGYYG 40
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1669-1716 7.30e-13

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 65.07  E-value: 7.30e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 386769627 1669 PCHCNGRSS---DCDRETGVCQnCRGNTGGDHCHQCAEGFYGDPNSPHGCQ 1716
Cdd:cd00055     1 PCDCNGHGSlsgQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1294-1342 5.43e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 62.76  E-value: 5.43e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 386769627  1294 CECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFGYPECRRCGC 1342
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1017-1065 7.21e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 59.68  E-value: 7.21e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 386769627 1017 PCHCHTEGSESGLCDSTDGQCLCKPRYAGQKCDECDVGYANVELRCPSC 1065
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 851-900 2.89e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 57.75  E-value: 2.89e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 386769627  851 PCPCNGH---SNSCDLQSGNCgDCMHNTFGDRCERCQLGYYGNPLQgtPNDCK 900
Cdd:cd00055     1 PCDCNGHgslSGQCDPGTGQC-ECKPNTTGRRCDRCAPGYYGLPSQ--GGGCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1772-1819 4.95e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 56.98  E-value: 4.95e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 386769627 1772 PCNCHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQAERHHL--VDNGCK 1819
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLpsQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 550-597 8.11e-10

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 56.59  E-value: 8.11e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 386769627   550 CECDERGSLGSTgsC---SGVCQCKLNVEGSTCSECAPGYFDLSAENAEGC 597
Cdd:pfam00053    1 CDCNPHGSLSDT--CdpeTGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 505-552 9.05e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 53.51  E-value: 9.05e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 386769627  505 PCSCNPARSTGG-CQSDGGSCNCLEGFQGKNCEECAPGYYGDDCKRCEC 552
Cdd:cd00055     1 PCDCNGHGSLSGqCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
Laminin_II super family cl05515
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 ...
 2279-2400 6.63e-08

Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


The actual alignment was detected with superfamily member pfam06009:

Pssm-ID: 368703 [Multi-domain]  Cd Length: 138  Bit Score: 54.03  E-value: 6.63e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  2279 EMADRTGEQMRAELQKAKDMQKSIQNMRNSFSNLEPDWEIKLGMAQeniSLTQTnLRLANVSLSYLEQQAE------KEQ 2352
Cdd:pfam06009    3 ELAREANETAKEVLEQLAPLSQNLENTSEKLSGINRSLEETNELVN---DANKA-LDDAGRSVKKLEELAPdlldklKPL 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 386769627  2353 QVFEVWNNSMAQQLQQLRDQIAKARHAAEAIDVSLeSLGPKCIRSYLP 2400
Cdd:pfam06009   79 KQLEVNSSSLSDNISRIKELIAQARKAANSIKVSV-SFDGDSIVELRP 125
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 974-1018 1.56e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.04  E-value: 1.56e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 386769627   974 CDC-----AGGPCNVTTGECItCRGNTEGWHCERCKLGYWGDPAVGCDPC 1018
Cdd:pfam00053    1 CDCnphgsLSDTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 401-450 1.69e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 50.05  E-value: 1.69e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 386769627  401 DCNGHANRSHeSPDDPLMQCICQHNTCGAQCEQCCPLFQDRPYQmGGECE 450
Cdd:cd00055     3 DCNGHGSLSG-QCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQ-GGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1718-1767 4.15e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 48.89  E-value: 4.15e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 386769627  1718 CPCPEtNRNFARGCNVWDGEvsCVCKPGYTGRLCERCQAGYFGDPMRYPN 1767
Cdd:pfam00053    1 CDCNP-HGSLSDTCDPETGQ--CLCKPGVTGRHCDRCKPGYYGLPSDPPQ 47
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1340-1392 2.30e-05

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 43.88  E-value: 2.30e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 386769627  1340 CGCDAEGSFtqadgSIACDSN-GQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGC 1392
Cdd:pfam00053    1 CDCNPHGSL-----SDTCDPEtGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2123-2390 3.10e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 50.06  E-value: 3.10e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  2123 VRKHWL--PKAEKHASHLLARSNEYARkfqptrNGARIAMLASSAHsNITEAINDARLASILAKERVYEAQRTLypSDGS 2200
Cdd:TIGR02168  655 VRPGGVitGGSAKTNSSILERRREIEE------LEEKIEELEEKIA-ELEKALAELRKELEELEEELEQLRKEL--EELS 725

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  2201 SMIERAKHSLHRSKQLQQEALKQMhksNVLKDKLHRQEQQVEGIKSTIYDSGLRTNNISGQLQGLSDgsARRQAKDSLEM 2280
Cdd:TIGR02168  726 RQISALRKDLARLEAEVEQLEERI---AQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEA--QIEQLKEELKA 800

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  2281 ADRTGEQMRAELQkakDMQKSIQNMRNSFSNLE---PDWEIKLGMAQENISLTQTNLRLANVSLSYLEQQAEKEQQVFEV 2357
Cdd:TIGR02168  801 LREALDELRAELT---LLNEEAANLRERLESLErriAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEA 877

                          250       260       270
                   ....*....|....*....|....*....|...
gi 386769627  2358 WNNSMAQQLQQLrdqiAKARHAAEAIDVSLESL 2390
Cdd:TIGR02168  878 LLNERASLEEAL----ALLRSELEELSEELREL 906
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1247-1292 3.32e-05

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 43.50  E-value: 3.32e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 386769627 1247 CSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWGWQAR-LGCR 1292
Cdd:cd00055     4 CNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQgGGCQ 50
LamG super family cl22861
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2399-2492 7.34e-05

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


The actual alignment was detected with superfamily member cd00110:

Pssm-ID: 473984 [Multi-domain]  Cd Length: 151  Bit Score: 45.49  E-value: 7.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627 2399 LPASYGLSTSNKIRMSFALSNhlESSPLIHLASSE-GRHITLELYKRRVRLVWNLGGTTATVTHPMVVHtrdpkyDDAWY 2477
Cdd:cd00110    12 LPTLPAPRTRLSISFSFRTTS--PNGLLLYAGSQNgGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLN------DGQWH 83

                          90
                  ....*....|....*
gi 386769627 2478 HVEANRTLNLGSLVV 2492
Cdd:cd00110    84 SVSVERNGRSVTLSV 98
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 943-971 2.81e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 40.80  E-value: 2.81e-04
                           10        20
                   ....*....|....*....|....*....
gi 386769627   943 QCPEGYTGDHCQVCDDGYFGNPRQPGSSC 971
Cdd:pfam00053   21 LCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
YhaN super family cl34808
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1907-2141 5.24e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


The actual alignment was detected with superfamily member COG4717:

Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 42.45  E-value: 5.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627 1907 AVATIGKREFAIKSMREDAVTQQHSVGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQARFYLQAIREHDQMVQGIR-ST 1985
Cdd:COG4717   288 LLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQlEE 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627 1986 NDCAWKHFYAMGNASDAsfDESGRLEMLWRDLNQTNHRVVDMRLQVDRV-------------QEVENEAEDVLEHVRNLS 2052
Cdd:COG4717   368 LEQEIAALLAEAGVEDE--EELRAALEQAEEYQELKEELEELEEQLEELlgeleellealdeEELEEELEELEEELEELE 445

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627 2053 IRVGESHQELDELNQRISDhldpgyLEQGEGLLRLTVQRQiMLNGHLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAE 2132
Cdd:COG4717   446 EELEELREELAELEAELEQ------LEEDGELAELLQELE-ELKAELRELAEEWAALKLALELLEEAREEYREERLPPVL 518


                  ....*....
gi 386769627 2133 KHASHLLAR 2141
Cdd:COG4717   519 ERASEYFSR 527
 
Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
153-398 4.27e-68

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 230.16  E-value: 4.27e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627   153 LYPPLFNVVPRAQISVNATCGQNGAEEYCKQVG---AKPCGICNahSSDRAKQRSIQSLIssgsgsGSGSGFEEGWWQSP 229
Cdd:pfam00055    1 CYPAFGNLAFGREVSATSTCGLNGPERYCILSGlegGKKCFICD--SRDPHNSHPPSNLT------DSNNGTNETWWQSE 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627   230 TLQggRQFEYVTILLDLKQTFQIFSVWLKSAnSPRPASWILEKSLD-GINFEPWQYFglsDADCQRRWNLsgQNGKYVFQ 308
Cdd:pfam00055   73 TGV--IQYENVNLTLDLGKEFHFTYLILKFK-SPRPAAMVLERSTDfGKTWQPYQYF---ASDCRRTFGR--PSGPSRGI 144

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627   309 NDTEIICSTQFSKPGPLENGVLHASLLKNRPGAT--DQSPELMKFITTRYIRIRLQGMHSTAnqdnslDWLLDSPSLEKH 386
Cdd:pfam00055  145 KDDEVICTSEYSDISPLTGGEVIFSTLEGRPSANifDYSPELQDWLTATNIRIRLLRLHTLG------DELLDDPSVLRK 218

                          250
                   ....*....|..
gi 386769627   387 SFYSLSQLKVSA 398
Cdd:pfam00055  219 YYYAISDISVGG 230
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 150-396 2.00e-52

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 185.26  E-value: 2.00e-52
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627    150 SGGLYPPLFNVVPRAQISVNATCGQNGAEEYCKQVG----AKPCGICNAhsSDRAKQRSIQSLISSGSGSGSGsgfeegW 225
Cdd:smart00136    4 PRSCYPPFVNLAFGREVTATSTCGEPGPERYCKLVGhteqGKKCDYCDA--RNPRRSHPAENLTDGNNPNNPT------W 75

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627    226 WQSPTLQGGRQfeYVTILLDLKQTFQIFSVWLKSAnSPRPASWILEKSLDGINFEPWQYFGlsdADCQRRWNL--SGQNG 303
Cdd:smart00136   76 WQSEPLSNGPQ--NVNLTLDLGKEFHVTYVILKFC-SPRPSLWILERSDFGKTWQPWQYFS---SDCRRTFGRppRGPIT 149

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627    304 KYvfqNDTEIICSTQFSKPGPLENGVLHASLLKNRPGATD--QSPELMKFITTRYIRIRLQGMHsTANQdnslDWLLDSP 381
Cdd:smart00136  150 KG---NEDEVICTSEYSDIVPLEGGEIAFSLLEGRPSATDfdNSPVLQEWVTATNIRVRLTRLR-TLGD----ELMDDRP 221

                           250
                    ....*....|....*
gi 386769627    382 SLEKHSFYSLSQLKV 396
Cdd:smart00136  222 EVTRRYYYAISDIAV 236
Laminin_B pfam00052
Laminin B (Domain IV);
1486-1626 1.20e-28

Laminin B (Domain IV);


Pssm-ID: 459652  Cd Length: 136  Bit Score: 113.13  E-value: 1.20e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  1486 YFQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLERNilgQYPLVQLHAHSKLLLDFYEYEEF-EYSLNVTHRVPLHESFW 1564
Cdd:pfam00052    1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGGGSLN---SEPDVILEGNGLRLSYSSPDQPPpDPGQEQTYSVRLHEENW 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 386769627  1565 KyHHTSQAVDRNTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAAIYikGSTNLIAKGVE 1626
Cdd:pfam00052   78 R-DSDGAPVSREDFMMVLANLTAILIRATYSTGSGQVSLSNVSLDSAVP--GGSGPPASWVE 136
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2804-2944 4.18e-26

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 105.58  E-value: 4.18e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  2804 FRTLQPDCLLLLAAYPPeilGDYdakdikgnFSISLVDGQLHVWVNSGRSFIKMSSNSSQMNDGEFHVVHLIKTGRKLEL 2883
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGG---SDF--------LALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTL 69

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 386769627  2884 MVDDELQEIRNLNGNPTVVSLPRDaggLYIGGAPPhESYTPLAPTFVNLEGAIRDVVFNNR 2944
Cdd:pfam02210   70 SVDGQTVVSSLPPGESLLLNLNGP---LYLGGLPP-LLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2586-2753 3.05e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 98.26  E-value: 3.05e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627 2586 ARHFNGLGYAQLmktRPRPTRKNLFSVQMTFRTLDENALLFLAVDDKNNRSVSVTLSRGRIMFRIDYGdESKLEINTTKK 2665
Cdd:cd00110     1 GVSFSGSSYVRL---PTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLG-SGSLVLSSKTP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627 2666 YNVGQWIKIeaarefSAKRSTENGMLRVNNDRPISGAPTLPVNIHLLPDLsktvYYLGGVPPGFTSGTSKAPgadNPFLG 2745
Cdd:cd00110    77 LNDGQWHSV------SVERNGRSVTLSVDGERVVESGSPGGSALLNLDGP----LYLGGLPEDLKSPGLPVS---PGFVG 143


                  ....*...
gi 386769627 2746 CMKDVQVN 2753
Cdd:cd00110   144 CIRDLKVN 151
Laminin_B pfam00052
Laminin B (Domain IV);
660-813 4.72e-22

Laminin B (Domain IV);


Pssm-ID: 459652  Cd Length: 136  Bit Score: 94.26  E-value: 4.72e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627   660 YWQASLGYLGNRLTSYGSRLQLVLSWDviRGDRSGKPTTGPNVILVGkNGLKIAFGDESLDGLGINLN----VTLTEVGW 735
Cdd:pfam00052    1 YWSAPEQFLGNKLTSYGGYLTYTVRYE--PLPGGGSLNSEPDVILEG-NGLRLSYSSPDQPPPDPGQEqtysVRLHEENW 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386769627   736 YHVPptvvdiktrlrrteggdyhGESVTRSQFLSVLVSLDAVLIRAAFHTDQGETSLERAVIYSGGVELGGKSSSQVE 813
Cdd:pfam00052   78 RDSD-------------------GAPVSREDFMMVLANLTAILIRATYSTGSGQVSLSNVSLDSAVPGGSGPPASWVE 136
LamB smart00281
Laminin B domain;
1482-1611 1.23e-21

Laminin B domain;


Pssm-ID: 214597  Cd Length: 127  Bit Score: 92.71  E-value: 1.23e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627   1482 YHPLYFQLPPQFYGDRTSSYGGFLYFTLITEGahkpLERNILGQYPLVQLH-AHSKLlldfyEYEEFEYSLN---VTHRV 1557
Cdd:smart00281    2 NEPVYWVAPEQFLGDKVTSYGGKLRYTLSFDG----RRGGTHVSAPDVILEgNGLRI-----SHPAEGPPLPdelTTVEV 72

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 386769627   1558 PLHESFWKYHHtSQAVDRNTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAA 1611
Cdd:smart00281   73 RFREENWQYYG-GRPVTREDLMMVLANLTAILIRATYSQQMAGSRLSDVSLEVA 125
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2616-2755 1.37e-21

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 92.87  E-value: 1.37e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  2616 FRTLDENALLFLAVDDKNNrSVSVTLSRGRIMFRIDYGDESKLEINTTKKYNVGQWIKIEAAREFSakrsteNGMLRVNN 2695
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSD-FLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGN------TLTLSVDG 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  2696 DRPISGAPTLPVnihlLPDLSKTVYYLGGVPPGFTSGTSKAPgadNPFLGCMKDVQVNGE 2755
Cdd:pfam02210   74 QTVVSSLPPGES----LLLNLNGPLYLGGLPPLLLLPALPVR---AGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
2611-2755 8.82e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 90.48  E-value: 8.82e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627   2611 SVQMTFRTLDENALLFLAVDDKNNRSVSVTLSRGRIMFRIDYGDESKLEINTTKKYNVGQWIKIeaarefSAKRSTENGM 2690
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRV------AVERNGRSVT 74

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 386769627   2691 LRVNNDRPISG-APTLPVNIHLlpdlsKTVYYLGGVPPGFTSGTSKAPgadNPFLGCMKDVQVNGE 2755
Cdd:smart00282   75 LSVDGGNRVSGeSPGGLTILNL-----DGPLYLGGLPEDLKLPPLPVT---PGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2779-2942 9.65e-21

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 91.33  E-value: 9.65e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627 2779 AGFSGNGYLELP-SQSLRKRSNTALVFRTLQPDCLLLLAAypPEILGDYdakdikgnFSISLVDGQLHVWVNSGRSFIKM 2857
Cdd:cd00110     2 VSFSGSSYVRLPtLPAPRTRLSISFSFRTTSPNGLLLYAG--SQNGGDF--------LALELEDGRLVLRYDLGSGSLVL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627 2858 SSnSSQMNDGEFHVVHLIKTGRKLELMVDDELQEIRNLNGNPTVVSLPrdaGGLYIGGAPPhESYTPLAPTFVNLEGAIR 2937
Cdd:cd00110    72 SS-KTPLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLD---GPLYLGGLPE-DLKSPGLPVSPGFVGCIR 146


                  ....*
gi 386769627 2938 DVVFN 2942
Cdd:cd00110   147 DLKVN 151
LamG smart00282
Laminin G domain;
2802-2944 9.21e-20

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 87.78  E-value: 9.21e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627   2802 LVFRTLQPDCLLLLAAYPPEilGDYdakdikgnFSISLVDGQLHVWVNSGRSFIKMSSNSSQMNDGEFHVVHLIKTGRKL 2881
Cdd:smart00282    4 FSFRTTSPNGLLLYAGSKGG--GDY--------LALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSV 73

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 386769627   2882 ELMVDDELQEIRNLNGNPTVVSLPrdaGGLYIGGAPPHESYTPLaPTFVNLEGAIRDVVFNNR 2944
Cdd:smart00282   74 TLSVDGGNRVSGESPGGLTILNLD---GPLYLGGLPEDLKLPPL-PVTPGFRGCIRNLKVNGK 132
LamB smart00281
Laminin B domain;
656-796 5.03e-15

Laminin B domain;


Pssm-ID: 214597  Cd Length: 127  Bit Score: 73.83  E-value: 5.03e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627    656 VEAIYWQASLGYLGNRLTSYGSRLQLVLSWDvirGDRSGKPTTGPNVILVGkNGLKIAFgdesldglginlnvtltevgW 735
Cdd:smart00281    2 NEPVYWVAPEQFLGDKVTSYGGKLRYTLSFD---GRRGGTHVSAPDVILEG-NGLRISH--------------------P 57

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386769627    736 YHVPP---TVVDIKTRLRRTEGGDYHGESVTRSQFLSVLVSLDAVLIRAAFHTDQ-----GETSLERAV 796
Cdd:smart00281   58 AEGPPlpdELTTVEVRFREENWQYYGGRPVTREDLMMVLANLTAILIRATYSQQMagsrlSDVSLEVAV 126
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1199-1247 2.79e-14

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 69.30  E-value: 2.79e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 386769627  1199 CRCDPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRC 1247
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1150-1197 1.14e-13

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 67.38  E-value: 1.14e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 386769627 1150 CHCSSVGSLSSDCDKRTGQCACLANVTGRRCDKCRPGHWNL-TAGEGCR 1197
Cdd:cd00055     2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLpSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1150-1196 1.44e-13

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 66.99  E-value: 1.44e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 386769627  1150 CHCSSVGSLSSDCDKRTGQCACLANVTGRRCDKCRPGHWNL--TAGEGC 1196
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLpsDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1199-1245 2.80e-13

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 66.22  E-value: 2.80e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 386769627 1199 CRCDPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFST--EGCQ 1245
Cdd:cd00055     2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSqgGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1065-1105 2.82e-13

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 66.22  E-value: 2.82e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 386769627  1065 CNCDPLGSlVQDRCDPHTGQCHCKEGVMGAKCHECQDGYFG 1105
Cdd:pfam00053    1 CDCNPHGS-LSDTCDPETGQCLCKPGVTGRHCDRCKPGYYG 40
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1199-1244 4.61e-13

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 65.41  E-value: 4.61e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 386769627   1199 CRCDPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGC 1244
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1150-1196 6.75e-13

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 65.03  E-value: 6.75e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 386769627   1150 CHCSSVGSLSSDCDKRTGQCACLANVTGRRCDKCRPGHWNLTaGEGC 1196
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDG-PPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1669-1716 7.30e-13

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 65.07  E-value: 7.30e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 386769627 1669 PCHCNGRSS---DCDRETGVCQnCRGNTGGDHCHQCAEGFYGDPNSPHGCQ 1716
Cdd:cd00055     1 PCDCNGHGSlsgQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1294-1342 5.43e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 62.76  E-value: 5.43e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 386769627  1294 CECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFGYPECRRCGC 1342
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1064-1105 8.48e-12

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 61.99  E-value: 8.48e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 386769627 1064 SCNCDPLGSlVQDRCDPHTGQCHCKEGVMGAKCHECQDGYFG 1105
Cdd:cd00055     1 PCDCNGHGS-LSGQCDPGTGQCECKPNTTGRRCDRCAPGYYG 41
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1065-1105 1.41e-11

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 61.56  E-value: 1.41e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 386769627   1065 CNCDPLGSlVQDRCDPHTGQCHCKEGVMGAKCHECQDGYFG 1105
Cdd:smart00180    1 CDCDPGGS-ASGTCDPDTGQCECKPNVTGRRCDRCAPGYYG 40
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1294-1336 1.51e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 61.60  E-value: 1.51e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 386769627 1294 CECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFGYPE 1336
Cdd:cd00055     2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPS 44
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1670-1715 1.74e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 61.22  E-value: 1.74e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 386769627  1670 CHCNGRSS---DCDRETGVCQnCRGNTGGDHCHQCAEGFYGDP-NSPHGC 1715
Cdd:pfam00053    1 CDCNPHGSlsdTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPsDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1017-1065 7.21e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 59.68  E-value: 7.21e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 386769627 1017 PCHCHTEGSESGLCDSTDGQCLCKPRYAGQKCDECDVGYANVELRCPSC 1065
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1294-1335 1.12e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 58.86  E-value: 1.12e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 386769627   1294 CECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFGYP 1335
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDG 42
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 851-900 2.89e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 57.75  E-value: 2.89e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 386769627  851 PCPCNGH---SNSCDLQSGNCgDCMHNTFGDRCERCQLGYYGNPLQgtPNDCK 900
Cdd:cd00055     1 PCDCNGHgslSGQCDPGTGQC-ECKPNTTGRRCDRCAPGYYGLPSQ--GGGCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1772-1819 4.95e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 56.98  E-value: 4.95e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 386769627 1772 PCNCHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQAERHHL--VDNGCK 1819
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLpsQGGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1773-1818 6.07e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 56.94  E-value: 6.07e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 386769627   1773 CNCHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQAERHHLVDNGC 1818
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 550-597 8.11e-10

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 56.59  E-value: 8.11e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 386769627   550 CECDERGSLGSTgsC---SGVCQCKLNVEGSTCSECAPGYFDLSAENAEGC 597
Cdd:pfam00053    1 CDCNPHGSLSDT--CdpeTGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 852-899 2.70e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 55.05  E-value: 2.70e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 386769627   852 CPCNGH---SNSCDLQSGNCgDCMHNTFGDRCERCQLGYYGNPlQGTPNDC 899
Cdd:pfam00053    1 CDCNPHgslSDTCDPETGQC-LCKPGVTGRHCDRCKPGYYGLP-SDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1018-1055 3.75e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 54.62  E-value: 3.75e-09
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 386769627   1018 CHCHTEGSESGLCDSTDGQCLCKPRYAGQKCDECDVGY 1055
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGY 38
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1773-1807 8.57e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 53.51  E-value: 8.57e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 386769627  1773 CNCHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQ 1807
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCK 35
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 505-552 9.05e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 53.51  E-value: 9.05e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 386769627  505 PCSCNPARSTGG-CQSDGGSCNCLEGFQGKNCEECAPGYYGDDCKRCEC 552
Cdd:cd00055     1 PCDCNGHGSLSGqCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
506-550 1.06e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 53.08  E-value: 1.06e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 386769627    506 CSCNPARS-TGGCQSDGGSCNCLEGFQGKNCEECAPGYYGDDCKRC 550
Cdd:smart00180    1 CDCDPGGSaSGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1670-1715 1.60e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 52.70  E-value: 1.60e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 386769627   1670 CHCNGR---SSDCDRETGVCQnCRGNTGGDHCHQCAEGFYGDpnSPHGC 1715
Cdd:smart00180    1 CDCDPGgsaSGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGD--GPPGC 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1018-1055 5.96e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 51.20  E-value: 5.96e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 386769627  1018 CHCHTEGSESGLCDSTDGQCLCKPRYAGQKCDECDVGY 1055
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGY 38
Laminin_II pfam06009
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 ...
 2279-2400 6.63e-08

Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


Pssm-ID: 368703 [Multi-domain]  Cd Length: 138  Bit Score: 54.03  E-value: 6.63e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  2279 EMADRTGEQMRAELQKAKDMQKSIQNMRNSFSNLEPDWEIKLGMAQeniSLTQTnLRLANVSLSYLEQQAE------KEQ 2352
Cdd:pfam06009    3 ELAREANETAKEVLEQLAPLSQNLENTSEKLSGINRSLEETNELVN---DANKA-LDDAGRSVKKLEELAPdlldklKPL 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 386769627  2353 QVFEVWNNSMAQQLQQLRDQIAKARHAAEAIDVSLeSLGPKCIRSYLP 2400
Cdd:pfam06009   79 KQLEVNSSSLSDNISRIKELIAQARKAANSIKVSV-SFDGDSIVELRP 125
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 506-545 7.92e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.81  E-value: 7.92e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 386769627   506 CSCNPARSTGG-CQSDGGSCNCLEGFQGKNCEECAPGYYGD 545
Cdd:pfam00053    1 CDCNPHGSLSDtCDPETGQCLCKPGVTGRHCDRCKPGYYGL 41
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 974-1018 1.56e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.04  E-value: 1.56e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 386769627   974 CDC-----AGGPCNVTTGECItCRGNTEGWHCERCKLGYWGDPAVGCDPC 1018
Cdd:pfam00053    1 CDCnphgsLSDTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 401-450 1.69e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 50.05  E-value: 1.69e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 386769627  401 DCNGHANRSHeSPDDPLMQCICQHNTCGAQCEQCCPLFQDRPYQmGGECE 450
Cdd:cd00055     3 DCNGHGSLSG-QCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQ-GGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
852-894 2.12e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 49.62  E-value: 2.12e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 386769627    852 CPCNG---HSNSCDLQSGNCgDCMHNTFGDRCERCQLGYYGNPLQG 894
Cdd:smart00180    1 CDCDPggsASGTCDPDTGQC-ECKPNVTGRRCDRCAPGYYGDGPPG 45
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 973-1014 2.12e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 49.66  E-value: 2.12e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 386769627  973 RCDC-----AGGPCNVTTGECItCRGNTEGWHCERCKLGYWGDPAVG 1014
Cdd:cd00055     1 PCDCnghgsLSGQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQG 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 549-598 2.25e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 49.66  E-value: 2.25e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 386769627  549 RCECDERGSLGSTgsC---SGVCQCKLNVEGSTCSECAPGYFDLsAENAEGCT 598
Cdd:cd00055     1 PCDCNGHGSLSGQ--CdpgTGQCECKPNTTGRRCDRCAPGYYGL-PSQGGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
974-1015 3.01e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 49.23  E-value: 3.01e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 386769627    974 CDC-----AGGPCNVTTGECiTCRGNTEGWHCERCKLGYWGDPAVGC 1015
Cdd:smart00180    1 CDCdpggsASGTCDPDTGQC-ECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
550-597 3.70e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 48.85  E-value: 3.70e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 386769627    550 CECDERGSLGSTgsC---SGVCQCKLNVEGSTCSECAPGYFDlsaENAEGC 597
Cdd:smart00180    1 CDCDPGGSASGT--CdpdTGQCECKPNVTGRRCDRCAPGYYG---DGPPGC 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1718-1767 4.15e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 48.89  E-value: 4.15e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 386769627  1718 CPCPEtNRNFARGCNVWDGEvsCVCKPGYTGRLCERCQAGYFGDPMRYPN 1767
Cdd:pfam00053    1 CDCNP-HGSLSDTCDPETGQ--CLCKPGVTGRHCDRCKPGYYGLPSDPPQ 47
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1718-1762 1.48e-06

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 47.31  E-value: 1.48e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 386769627   1718 CPCPETNrNFARGCNVWDGEvsCVCKPGYTGRLCERCQAGYFGDP 1762
Cdd:smart00180    1 CDCDPGG-SASGTCDPDTGQ--CECKPNVTGRRCDRCAPGYYGDG 42
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1717-1762 1.68e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 46.96  E-value: 1.68e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 386769627 1717 ACPCPeTNRNFARGCNVWDGEvsCVCKPGYTGRLCERCQAGYFGDP 1762
Cdd:cd00055     1 PCDCN-GHGSLSGQCDPGTGQ--CECKPNTTGRRCDRCAPGYYGLP 43
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1340-1392 2.30e-05

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 43.88  E-value: 2.30e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 386769627  1340 CGCDAEGSFtqadgSIACDSN-GQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGC 1392
Cdd:pfam00053    1 CDCNPHGSL-----SDTCDPEtGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2123-2390 3.10e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 50.06  E-value: 3.10e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  2123 VRKHWL--PKAEKHASHLLARSNEYARkfqptrNGARIAMLASSAHsNITEAINDARLASILAKERVYEAQRTLypSDGS 2200
Cdd:TIGR02168  655 VRPGGVitGGSAKTNSSILERRREIEE------LEEKIEELEEKIA-ELEKALAELRKELEELEEELEQLRKEL--EELS 725

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  2201 SMIERAKHSLHRSKQLQQEALKQMhksNVLKDKLHRQEQQVEGIKSTIYDSGLRTNNISGQLQGLSDgsARRQAKDSLEM 2280
Cdd:TIGR02168  726 RQISALRKDLARLEAEVEQLEERI---AQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEA--QIEQLKEELKA 800

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  2281 ADRTGEQMRAELQkakDMQKSIQNMRNSFSNLE---PDWEIKLGMAQENISLTQTNLRLANVSLSYLEQQAEKEQQVFEV 2357
Cdd:TIGR02168  801 LREALDELRAELT---LLNEEAANLRERLESLErriAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEA 877

                          250       260       270
                   ....*....|....*....|....*....|...
gi 386769627  2358 WNNSMAQQLQQLrdqiAKARHAAEAIDVSLESL 2390
Cdd:TIGR02168  878 LLNERASLEEAL----ALLRSELEELSEELREL 906
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1247-1292 3.32e-05

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 43.50  E-value: 3.32e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 386769627 1247 CSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWGWQAR-LGCR 1292
Cdd:cd00055     4 CNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQgGGCQ 50
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2399-2492 7.34e-05

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 45.49  E-value: 7.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627 2399 LPASYGLSTSNKIRMSFALSNhlESSPLIHLASSE-GRHITLELYKRRVRLVWNLGGTTATVTHPMVVHtrdpkyDDAWY 2477
Cdd:cd00110    12 LPTLPAPRTRLSISFSFRTTS--PNGLLLYAGSQNgGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLN------DGQWH 83

                          90
                  ....*....|....*
gi 386769627 2478 HVEANRTLNLGSLVV 2492
Cdd:cd00110    84 SVSVERNGRSVTLSV 98
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 943-971 2.81e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 40.80  E-value: 2.81e-04
                           10        20
                   ....*....|....*....|....*....
gi 386769627   943 QCPEGYTGDHCQVCDDGYFGNPRQPGSSC 971
Cdd:pfam00053   21 LCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
LamG smart00282
Laminin G domain;
2426-2492 2.85e-04

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 43.10  E-value: 2.85e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386769627   2426 LIHLASSEG-RHITLELYKRRVRLVWNLGGTTATVTHPmvvhtrDPKYDD-AWYHVEANRTLNLGSLVV 2492
Cdd:smart00282   15 LLYAGSKGGgDYLALELRDGRLVLRYDLGSGPARLTSD------PTPLNDgQWHRVAVERNGRSVTLSV 77
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1340-1392 3.47e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 40.37  E-value: 3.47e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 386769627   1340 CGCDAEGSFTQAdgsiaCDS-NGQCPCKSLVVGLKCDTCMQSTFGlsaQNPEGC 1392
Cdd:smart00180    1 CDCDPGGSASGT-----CDPdTGQCECKPNVTGRRCDRCAPGYYG---DGPPGC 46
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2426-2492 4.02e-04

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 42.79  E-value: 4.02e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386769627  2426 LIHLASSEGRHITLELYKRRVRLVWNLGGttatvtHPMVVHTRDPKYDD-AWYHVEANRTLNLGSLVV 2492
Cdd:pfam02210   10 LLYAGGGGSDFLALELVNGRLVLRYDLGS------GPESLLSSGKNLNDgQWHSVRVERNGNTLTLSV 71
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1339-1393 6.59e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 39.64  E-value: 6.59e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 386769627 1339 RCGCDAEGSFtqadgSIACDS-NGQCPCKSLVVGLKCDTCMQSTFGLSAQnPEGCT 1393
Cdd:cd00055     1 PCDCNGHGSL-----SGQCDPgTGQCECKPNTTGRRCDRCAPGYYGLPSQ-GGGCQ 50
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
2178-2390 1.02e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 44.76  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627 2178 LASILA--KERVYEAQRTLYPSDGSSmIERAKHSLHRSKQLQQEALKQMHKSNVLKDKLHRQEQQVEGIKSTIYDSGLRT 2255
Cdd:COG4717    40 LAFIRAmlLERLEKEADELFKPQGRK-PELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREEL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627 2256 NNISGQLQGLSDGSARRQAKDSLEMADRTGEQMRAELQKAKDMQKSIQNMRNSFSNLEpdweiklgmaqenISLTQTNLR 2335
Cdd:COG4717   119 EKLEKLLQLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQ-------------EELEELLEQ 185

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 386769627 2336 LANVSLSYLEQQAEKEQQVfevwnnsmAQQLQQLRDQIAKARHAAEAIDVSLESL 2390
Cdd:COG4717   186 LSLATEEELQDLAEELEEL--------QQRLAELEEELEEAQEELEELEEELEQL 232
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1247-1284 1.08e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 39.22  E-value: 1.08e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 386769627   1247 CSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWG 1284
Cdd:smart00180    3 CDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYG 40
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1247-1284 1.43e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 38.87  E-value: 1.43e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 386769627  1247 CSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWG 1284
Cdd:pfam00053    3 CNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYG 40
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 2212-2375 1.73e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 43.86  E-value: 1.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  2212 RSKQLQQEALKQMHKSNVLKDKLHRQEQQVEGIKSTIydsglrtNNISGQLQGLSDgsarRQAKDSLEMADRTGEQMRAE 2291
Cdd:TIGR04523  212 KNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEI-------SNTQTQLNQLKD----EQNKIKKQLSEKQKELEQNN 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  2292 lQKAKDMQKSIQNMRNSFSNL----EPDW--EIK--LGMAQENISLTQTNLRLANVSLSYLEQQA---EKEQQVFEVWNN 2360
Cdd:TIGR04523  281 -KKIKELEKQLNQLKSEISDLnnqkEQDWnkELKseLKNQEKKLEEIQNQISQNNKIISQLNEQIsqlKKELTNSESENS 359

                          170
                   ....*....|....*
gi 386769627  2361 SMAQQLQQLRDQIAK 2375
Cdd:TIGR04523  360 EKQRELEEKQNEIEK 374
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 401-449 1.79e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 38.49  E-value: 1.79e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 386769627   401 DCNGHAnrSHESPDDPL-MQCICQHNTCGAQCEQCCPLFQDRPYQMGGEC 449
Cdd:pfam00053    2 DCNPHG--SLSDTCDPEtGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1907-2141 5.24e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 42.45  E-value: 5.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627 1907 AVATIGKREFAIKSMREDAVTQQHSVGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQARFYLQAIREHDQMVQGIR-ST 1985
Cdd:COG4717   288 LLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQlEE 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627 1986 NDCAWKHFYAMGNASDAsfDESGRLEMLWRDLNQTNHRVVDMRLQVDRV-------------QEVENEAEDVLEHVRNLS 2052
Cdd:COG4717   368 LEQEIAALLAEAGVEDE--EELRAALEQAEEYQELKEELEELEEQLEELlgeleellealdeEELEEELEELEEELEELE 445

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627 2053 IRVGESHQELDELNQRISDhldpgyLEQGEGLLRLTVQRQiMLNGHLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAE 2132
Cdd:COG4717   446 EELEELREELAELEAELEQ------LEEDGELAELLQELE-ELKAELRELAEEWAALKLALELLEEAREEYREERLPPVL 518


                  ....*....
gi 386769627 2133 KHASHLLAR 2141
Cdd:COG4717   519 ERASEYFSR 527
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
401-444 6.66e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 36.91  E-value: 6.66e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 386769627    401 DCNGHANrSHESPDDPLMQCICQHNTCGAQCEQCCPLFQDRPYQ 444
Cdd:smart00180    2 DCDPGGS-ASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPP 44
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 943-972 8.62e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 36.56  E-value: 8.62e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 386769627  943 QCPEGYTGDHCQVCDDGYFGNPRQPGsSCQ 972
Cdd:cd00055    22 ECKPNTTGRRCDRCAPGYYGLPSQGG-GCQ 50
 
Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
153-398 4.27e-68

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 230.16  E-value: 4.27e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627   153 LYPPLFNVVPRAQISVNATCGQNGAEEYCKQVG---AKPCGICNahSSDRAKQRSIQSLIssgsgsGSGSGFEEGWWQSP 229
Cdd:pfam00055    1 CYPAFGNLAFGREVSATSTCGLNGPERYCILSGlegGKKCFICD--SRDPHNSHPPSNLT------DSNNGTNETWWQSE 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627   230 TLQggRQFEYVTILLDLKQTFQIFSVWLKSAnSPRPASWILEKSLD-GINFEPWQYFglsDADCQRRWNLsgQNGKYVFQ 308
Cdd:pfam00055   73 TGV--IQYENVNLTLDLGKEFHFTYLILKFK-SPRPAAMVLERSTDfGKTWQPYQYF---ASDCRRTFGR--PSGPSRGI 144

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627   309 NDTEIICSTQFSKPGPLENGVLHASLLKNRPGAT--DQSPELMKFITTRYIRIRLQGMHSTAnqdnslDWLLDSPSLEKH 386
Cdd:pfam00055  145 KDDEVICTSEYSDISPLTGGEVIFSTLEGRPSANifDYSPELQDWLTATNIRIRLLRLHTLG------DELLDDPSVLRK 218

                          250
                   ....*....|..
gi 386769627   387 SFYSLSQLKVSA 398
Cdd:pfam00055  219 YYYAISDISVGG 230
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 150-396 2.00e-52

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 185.26  E-value: 2.00e-52
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627    150 SGGLYPPLFNVVPRAQISVNATCGQNGAEEYCKQVG----AKPCGICNAhsSDRAKQRSIQSLISSGSGSGSGsgfeegW 225
Cdd:smart00136    4 PRSCYPPFVNLAFGREVTATSTCGEPGPERYCKLVGhteqGKKCDYCDA--RNPRRSHPAENLTDGNNPNNPT------W 75

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627    226 WQSPTLQGGRQfeYVTILLDLKQTFQIFSVWLKSAnSPRPASWILEKSLDGINFEPWQYFGlsdADCQRRWNL--SGQNG 303
Cdd:smart00136   76 WQSEPLSNGPQ--NVNLTLDLGKEFHVTYVILKFC-SPRPSLWILERSDFGKTWQPWQYFS---SDCRRTFGRppRGPIT 149

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627    304 KYvfqNDTEIICSTQFSKPGPLENGVLHASLLKNRPGATD--QSPELMKFITTRYIRIRLQGMHsTANQdnslDWLLDSP 381
Cdd:smart00136  150 KG---NEDEVICTSEYSDIVPLEGGEIAFSLLEGRPSATDfdNSPVLQEWVTATNIRVRLTRLR-TLGD----ELMDDRP 221

                           250
                    ....*....|....*
gi 386769627    382 SLEKHSFYSLSQLKV 396
Cdd:smart00136  222 EVTRRYYYAISDIAV 236
Laminin_B pfam00052
Laminin B (Domain IV);
1486-1626 1.20e-28

Laminin B (Domain IV);


Pssm-ID: 459652  Cd Length: 136  Bit Score: 113.13  E-value: 1.20e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  1486 YFQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLERNilgQYPLVQLHAHSKLLLDFYEYEEF-EYSLNVTHRVPLHESFW 1564
Cdd:pfam00052    1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGGGSLN---SEPDVILEGNGLRLSYSSPDQPPpDPGQEQTYSVRLHEENW 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 386769627  1565 KyHHTSQAVDRNTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAAIYikGSTNLIAKGVE 1626
Cdd:pfam00052   78 R-DSDGAPVSREDFMMVLANLTAILIRATYSTGSGQVSLSNVSLDSAVP--GGSGPPASWVE 136
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2804-2944 4.18e-26

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 105.58  E-value: 4.18e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  2804 FRTLQPDCLLLLAAYPPeilGDYdakdikgnFSISLVDGQLHVWVNSGRSFIKMSSNSSQMNDGEFHVVHLIKTGRKLEL 2883
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGG---SDF--------LALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTL 69

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 386769627  2884 MVDDELQEIRNLNGNPTVVSLPRDaggLYIGGAPPhESYTPLAPTFVNLEGAIRDVVFNNR 2944
Cdd:pfam02210   70 SVDGQTVVSSLPPGESLLLNLNGP---LYLGGLPP-LLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2586-2753 3.05e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 98.26  E-value: 3.05e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627 2586 ARHFNGLGYAQLmktRPRPTRKNLFSVQMTFRTLDENALLFLAVDDKNNRSVSVTLSRGRIMFRIDYGdESKLEINTTKK 2665
Cdd:cd00110     1 GVSFSGSSYVRL---PTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLG-SGSLVLSSKTP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627 2666 YNVGQWIKIeaarefSAKRSTENGMLRVNNDRPISGAPTLPVNIHLLPDLsktvYYLGGVPPGFTSGTSKAPgadNPFLG 2745
Cdd:cd00110    77 LNDGQWHSV------SVERNGRSVTLSVDGERVVESGSPGGSALLNLDGP----LYLGGLPEDLKSPGLPVS---PGFVG 143


                  ....*...
gi 386769627 2746 CMKDVQVN 2753
Cdd:cd00110   144 CIRDLKVN 151
Laminin_B pfam00052
Laminin B (Domain IV);
660-813 4.72e-22

Laminin B (Domain IV);


Pssm-ID: 459652  Cd Length: 136  Bit Score: 94.26  E-value: 4.72e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627   660 YWQASLGYLGNRLTSYGSRLQLVLSWDviRGDRSGKPTTGPNVILVGkNGLKIAFGDESLDGLGINLN----VTLTEVGW 735
Cdd:pfam00052    1 YWSAPEQFLGNKLTSYGGYLTYTVRYE--PLPGGGSLNSEPDVILEG-NGLRLSYSSPDQPPPDPGQEqtysVRLHEENW 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386769627   736 YHVPptvvdiktrlrrteggdyhGESVTRSQFLSVLVSLDAVLIRAAFHTDQGETSLERAVIYSGGVELGGKSSSQVE 813
Cdd:pfam00052   78 RDSD-------------------GAPVSREDFMMVLANLTAILIRATYSTGSGQVSLSNVSLDSAVPGGSGPPASWVE 136
LamB smart00281
Laminin B domain;
1482-1611 1.23e-21

Laminin B domain;


Pssm-ID: 214597  Cd Length: 127  Bit Score: 92.71  E-value: 1.23e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627   1482 YHPLYFQLPPQFYGDRTSSYGGFLYFTLITEGahkpLERNILGQYPLVQLH-AHSKLlldfyEYEEFEYSLN---VTHRV 1557
Cdd:smart00281    2 NEPVYWVAPEQFLGDKVTSYGGKLRYTLSFDG----RRGGTHVSAPDVILEgNGLRI-----SHPAEGPPLPdelTTVEV 72

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 386769627   1558 PLHESFWKYHHtSQAVDRNTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAA 1611
Cdd:smart00281   73 RFREENWQYYG-GRPVTREDLMMVLANLTAILIRATYSQQMAGSRLSDVSLEVA 125
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2616-2755 1.37e-21

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 92.87  E-value: 1.37e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  2616 FRTLDENALLFLAVDDKNNrSVSVTLSRGRIMFRIDYGDESKLEINTTKKYNVGQWIKIEAAREFSakrsteNGMLRVNN 2695
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSD-FLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGN------TLTLSVDG 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  2696 DRPISGAPTLPVnihlLPDLSKTVYYLGGVPPGFTSGTSKAPgadNPFLGCMKDVQVNGE 2755
Cdd:pfam02210   74 QTVVSSLPPGES----LLLNLNGPLYLGGLPPLLLLPALPVR---AGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
2611-2755 8.82e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 90.48  E-value: 8.82e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627   2611 SVQMTFRTLDENALLFLAVDDKNNRSVSVTLSRGRIMFRIDYGDESKLEINTTKKYNVGQWIKIeaarefSAKRSTENGM 2690
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRV------AVERNGRSVT 74

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 386769627   2691 LRVNNDRPISG-APTLPVNIHLlpdlsKTVYYLGGVPPGFTSGTSKAPgadNPFLGCMKDVQVNGE 2755
Cdd:smart00282   75 LSVDGGNRVSGeSPGGLTILNL-----DGPLYLGGLPEDLKLPPLPVT---PGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2779-2942 9.65e-21

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 91.33  E-value: 9.65e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627 2779 AGFSGNGYLELP-SQSLRKRSNTALVFRTLQPDCLLLLAAypPEILGDYdakdikgnFSISLVDGQLHVWVNSGRSFIKM 2857
Cdd:cd00110     2 VSFSGSSYVRLPtLPAPRTRLSISFSFRTTSPNGLLLYAG--SQNGGDF--------LALELEDGRLVLRYDLGSGSLVL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627 2858 SSnSSQMNDGEFHVVHLIKTGRKLELMVDDELQEIRNLNGNPTVVSLPrdaGGLYIGGAPPhESYTPLAPTFVNLEGAIR 2937
Cdd:cd00110    72 SS-KTPLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLD---GPLYLGGLPE-DLKSPGLPVSPGFVGCIR 146


                  ....*
gi 386769627 2938 DVVFN 2942
Cdd:cd00110   147 DLKVN 151
LamG smart00282
Laminin G domain;
2802-2944 9.21e-20

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 87.78  E-value: 9.21e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627   2802 LVFRTLQPDCLLLLAAYPPEilGDYdakdikgnFSISLVDGQLHVWVNSGRSFIKMSSNSSQMNDGEFHVVHLIKTGRKL 2881
Cdd:smart00282    4 FSFRTTSPNGLLLYAGSKGG--GDY--------LALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSV 73

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 386769627   2882 ELMVDDELQEIRNLNGNPTVVSLPrdaGGLYIGGAPPHESYTPLaPTFVNLEGAIRDVVFNNR 2944
Cdd:smart00282   74 TLSVDGGNRVSGESPGGLTILNLD---GPLYLGGLPEDLKLPPL-PVTPGFRGCIRNLKVNGK 132
LamB smart00281
Laminin B domain;
656-796 5.03e-15

Laminin B domain;


Pssm-ID: 214597  Cd Length: 127  Bit Score: 73.83  E-value: 5.03e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627    656 VEAIYWQASLGYLGNRLTSYGSRLQLVLSWDvirGDRSGKPTTGPNVILVGkNGLKIAFgdesldglginlnvtltevgW 735
Cdd:smart00281    2 NEPVYWVAPEQFLGDKVTSYGGKLRYTLSFD---GRRGGTHVSAPDVILEG-NGLRISH--------------------P 57

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386769627    736 YHVPP---TVVDIKTRLRRTEGGDYHGESVTRSQFLSVLVSLDAVLIRAAFHTDQ-----GETSLERAV 796
Cdd:smart00281   58 AEGPPlpdELTTVEVRFREENWQYYGGRPVTREDLMMVLANLTAILIRATYSQQMagsrlSDVSLEVAV 126
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1199-1247 2.79e-14

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 69.30  E-value: 2.79e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 386769627  1199 CRCDPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRC 1247
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_G_1 pfam00054
Laminin G domain;
2804-2947 1.01e-13

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 70.42  E-value: 1.01e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  2804 FRTLQPDCLLLLAAYPPEilGDYdakdikgnFSISLVDGQLHVWVNSGRSFIKMSSNSsQMNDGEFHVVHLIKTGRKLEL 2883
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTE--RDF--------LALELRDGRLEVSYDLGSGAAVVRSGD-KLNDGKWHSVELERNGRSGTL 69

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 386769627  2884 MVDDELQE-IRNLNGNPTVVSLPrdaGGLYIGGAPPHESYTPLAPTFVNLEGAIRDVVFNNRTIN 2947
Cdd:pfam00054   70 SVDGEARPtGESPLGATTDLDVD---GPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1150-1197 1.14e-13

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 67.38  E-value: 1.14e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 386769627 1150 CHCSSVGSLSSDCDKRTGQCACLANVTGRRCDKCRPGHWNL-TAGEGCR 1197
Cdd:cd00055     2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLpSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1150-1196 1.44e-13

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 66.99  E-value: 1.44e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 386769627  1150 CHCSSVGSLSSDCDKRTGQCACLANVTGRRCDKCRPGHWNL--TAGEGC 1196
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLpsDPPQGC 49
Laminin_G_1 pfam00054
Laminin G domain;
2616-2758 2.34e-13

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 69.27  E-value: 2.34e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  2616 FRTLDENALLFLAVDDKNNRSVSVTLSRGRIMFRIDYGD-ESKLEINTtkKYNVGQWIKIEaarefsAKRSTENGMLRVN 2694
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSgAAVVRSGD--KLNDGKWHSVE------LERNGRSGTLSVD 72

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 386769627  2695 NDRPISGAPTLPVNIHLlpDLSKTvYYLGGVPPgftSGTSKAPGADNP-FLGCMKDVQVNGETYD 2758
Cdd:pfam00054   73 GEARPTGESPLGATTDL--DVDGP-LYVGGLPS---LGVKKRRLAISPsFDGCIRDVIVNGKPLD 131
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1199-1245 2.80e-13

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 66.22  E-value: 2.80e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 386769627 1199 CRCDPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFST--EGCQ 1245
Cdd:cd00055     2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSqgGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1065-1105 2.82e-13

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 66.22  E-value: 2.82e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 386769627  1065 CNCDPLGSlVQDRCDPHTGQCHCKEGVMGAKCHECQDGYFG 1105
Cdd:pfam00053    1 CDCNPHGS-LSDTCDPETGQCLCKPGVTGRHCDRCKPGYYG 40
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1199-1244 4.61e-13

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 65.41  E-value: 4.61e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 386769627   1199 CRCDPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGC 1244
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1150-1196 6.75e-13

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 65.03  E-value: 6.75e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 386769627   1150 CHCSSVGSLSSDCDKRTGQCACLANVTGRRCDKCRPGHWNLTaGEGC 1196
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDG-PPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1669-1716 7.30e-13

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 65.07  E-value: 7.30e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 386769627 1669 PCHCNGRSS---DCDRETGVCQnCRGNTGGDHCHQCAEGFYGDPNSPHGCQ 1716
Cdd:cd00055     1 PCDCNGHGSlsgQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1294-1342 5.43e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 62.76  E-value: 5.43e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 386769627  1294 CECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFGYPECRRCGC 1342
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1064-1105 8.48e-12

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 61.99  E-value: 8.48e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 386769627 1064 SCNCDPLGSlVQDRCDPHTGQCHCKEGVMGAKCHECQDGYFG 1105
Cdd:cd00055     1 PCDCNGHGS-LSGQCDPGTGQCECKPNTTGRRCDRCAPGYYG 41
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1065-1105 1.41e-11

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 61.56  E-value: 1.41e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 386769627   1065 CNCDPLGSlVQDRCDPHTGQCHCKEGVMGAKCHECQDGYFG 1105
Cdd:smart00180    1 CDCDPGGS-ASGTCDPDTGQCECKPNVTGRRCDRCAPGYYG 40
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1294-1336 1.51e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 61.60  E-value: 1.51e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 386769627 1294 CECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFGYPE 1336
Cdd:cd00055     2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPS 44
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1670-1715 1.74e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 61.22  E-value: 1.74e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 386769627  1670 CHCNGRSS---DCDRETGVCQnCRGNTGGDHCHQCAEGFYGDP-NSPHGC 1715
Cdd:pfam00053    1 CDCNPHGSlsdTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPsDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1017-1065 7.21e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 59.68  E-value: 7.21e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 386769627 1017 PCHCHTEGSESGLCDSTDGQCLCKPRYAGQKCDECDVGYANVELRCPSC 1065
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1294-1335 1.12e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 58.86  E-value: 1.12e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 386769627   1294 CECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFGYP 1335
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDG 42
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 851-900 2.89e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 57.75  E-value: 2.89e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 386769627  851 PCPCNGH---SNSCDLQSGNCgDCMHNTFGDRCERCQLGYYGNPLQgtPNDCK 900
Cdd:cd00055     1 PCDCNGHgslSGQCDPGTGQC-ECKPNTTGRRCDRCAPGYYGLPSQ--GGGCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1772-1819 4.95e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 56.98  E-value: 4.95e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 386769627 1772 PCNCHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQAERHHL--VDNGCK 1819
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLpsQGGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1773-1818 6.07e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 56.94  E-value: 6.07e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 386769627   1773 CNCHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQAERHHLVDNGC 1818
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 550-597 8.11e-10

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 56.59  E-value: 8.11e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 386769627   550 CECDERGSLGSTgsC---SGVCQCKLNVEGSTCSECAPGYFDLSAENAEGC 597
Cdd:pfam00053    1 CDCNPHGSLSDT--CdpeTGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 852-899 2.70e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 55.05  E-value: 2.70e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 386769627   852 CPCNGH---SNSCDLQSGNCgDCMHNTFGDRCERCQLGYYGNPlQGTPNDC 899
Cdd:pfam00053    1 CDCNPHgslSDTCDPETGQC-LCKPGVTGRHCDRCKPGYYGLP-SDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1018-1055 3.75e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 54.62  E-value: 3.75e-09
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 386769627   1018 CHCHTEGSESGLCDSTDGQCLCKPRYAGQKCDECDVGY 1055
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGY 38
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1773-1807 8.57e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 53.51  E-value: 8.57e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 386769627  1773 CNCHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQ 1807
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCK 35
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 505-552 9.05e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 53.51  E-value: 9.05e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 386769627  505 PCSCNPARSTGG-CQSDGGSCNCLEGFQGKNCEECAPGYYGDDCKRCEC 552
Cdd:cd00055     1 PCDCNGHGSLSGqCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
506-550 1.06e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 53.08  E-value: 1.06e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 386769627    506 CSCNPARS-TGGCQSDGGSCNCLEGFQGKNCEECAPGYYGDDCKRC 550
Cdd:smart00180    1 CDCDPGGSaSGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1670-1715 1.60e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 52.70  E-value: 1.60e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 386769627   1670 CHCNGR---SSDCDRETGVCQnCRGNTGGDHCHQCAEGFYGDpnSPHGC 1715
Cdd:smart00180    1 CDCDPGgsaSGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGD--GPPGC 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1018-1055 5.96e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 51.20  E-value: 5.96e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 386769627  1018 CHCHTEGSESGLCDSTDGQCLCKPRYAGQKCDECDVGY 1055
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGY 38
Laminin_II pfam06009
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 ...
 2279-2400 6.63e-08

Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


Pssm-ID: 368703 [Multi-domain]  Cd Length: 138  Bit Score: 54.03  E-value: 6.63e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  2279 EMADRTGEQMRAELQKAKDMQKSIQNMRNSFSNLEPDWEIKLGMAQeniSLTQTnLRLANVSLSYLEQQAE------KEQ 2352
Cdd:pfam06009    3 ELAREANETAKEVLEQLAPLSQNLENTSEKLSGINRSLEETNELVN---DANKA-LDDAGRSVKKLEELAPdlldklKPL 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 386769627  2353 QVFEVWNNSMAQQLQQLRDQIAKARHAAEAIDVSLeSLGPKCIRSYLP 2400
Cdd:pfam06009   79 KQLEVNSSSLSDNISRIKELIAQARKAANSIKVSV-SFDGDSIVELRP 125
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 506-545 7.92e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.81  E-value: 7.92e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 386769627   506 CSCNPARSTGG-CQSDGGSCNCLEGFQGKNCEECAPGYYGD 545
Cdd:pfam00053    1 CDCNPHGSLSDtCDPETGQCLCKPGVTGRHCDRCKPGYYGL 41
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 974-1018 1.56e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.04  E-value: 1.56e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 386769627   974 CDC-----AGGPCNVTTGECItCRGNTEGWHCERCKLGYWGDPAVGCDPC 1018
Cdd:pfam00053    1 CDCnphgsLSDTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 401-450 1.69e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 50.05  E-value: 1.69e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 386769627  401 DCNGHANRSHeSPDDPLMQCICQHNTCGAQCEQCCPLFQDRPYQmGGECE 450
Cdd:cd00055     3 DCNGHGSLSG-QCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQ-GGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
852-894 2.12e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 49.62  E-value: 2.12e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 386769627    852 CPCNG---HSNSCDLQSGNCgDCMHNTFGDRCERCQLGYYGNPLQG 894
Cdd:smart00180    1 CDCDPggsASGTCDPDTGQC-ECKPNVTGRRCDRCAPGYYGDGPPG 45
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 973-1014 2.12e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 49.66  E-value: 2.12e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 386769627  973 RCDC-----AGGPCNVTTGECItCRGNTEGWHCERCKLGYWGDPAVG 1014
Cdd:cd00055     1 PCDCnghgsLSGQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQG 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 549-598 2.25e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 49.66  E-value: 2.25e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 386769627  549 RCECDERGSLGSTgsC---SGVCQCKLNVEGSTCSECAPGYFDLsAENAEGCT 598
Cdd:cd00055     1 PCDCNGHGSLSGQ--CdpgTGQCECKPNTTGRRCDRCAPGYYGL-PSQGGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
974-1015 3.01e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 49.23  E-value: 3.01e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 386769627    974 CDC-----AGGPCNVTTGECiTCRGNTEGWHCERCKLGYWGDPAVGC 1015
Cdd:smart00180    1 CDCdpggsASGTCDPDTGQC-ECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
550-597 3.70e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 48.85  E-value: 3.70e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 386769627    550 CECDERGSLGSTgsC---SGVCQCKLNVEGSTCSECAPGYFDlsaENAEGC 597
Cdd:smart00180    1 CDCDPGGSASGT--CdpdTGQCECKPNVTGRRCDRCAPGYYG---DGPPGC 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1718-1767 4.15e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 48.89  E-value: 4.15e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 386769627  1718 CPCPEtNRNFARGCNVWDGEvsCVCKPGYTGRLCERCQAGYFGDPMRYPN 1767
Cdd:pfam00053    1 CDCNP-HGSLSDTCDPETGQ--CLCKPGVTGRHCDRCKPGYYGLPSDPPQ 47
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1718-1762 1.48e-06

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 47.31  E-value: 1.48e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 386769627   1718 CPCPETNrNFARGCNVWDGEvsCVCKPGYTGRLCERCQAGYFGDP 1762
Cdd:smart00180    1 CDCDPGG-SASGTCDPDTGQ--CECKPNVTGRRCDRCAPGYYGDG 42
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1717-1762 1.68e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 46.96  E-value: 1.68e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 386769627 1717 ACPCPeTNRNFARGCNVWDGEvsCVCKPGYTGRLCERCQAGYFGDP 1762
Cdd:cd00055     1 PCDCN-GHGSLSGQCDPGTGQ--CECKPNTTGRRCDRCAPGYYGLP 43
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1340-1392 2.30e-05

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 43.88  E-value: 2.30e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 386769627  1340 CGCDAEGSFtqadgSIACDSN-GQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGC 1392
Cdd:pfam00053    1 CDCNPHGSL-----SDTCDPEtGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2123-2390 3.10e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 50.06  E-value: 3.10e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  2123 VRKHWL--PKAEKHASHLLARSNEYARkfqptrNGARIAMLASSAHsNITEAINDARLASILAKERVYEAQRTLypSDGS 2200
Cdd:TIGR02168  655 VRPGGVitGGSAKTNSSILERRREIEE------LEEKIEELEEKIA-ELEKALAELRKELEELEEELEQLRKEL--EELS 725

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  2201 SMIERAKHSLHRSKQLQQEALKQMhksNVLKDKLHRQEQQVEGIKSTIYDSGLRTNNISGQLQGLSDgsARRQAKDSLEM 2280
Cdd:TIGR02168  726 RQISALRKDLARLEAEVEQLEERI---AQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEA--QIEQLKEELKA 800

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  2281 ADRTGEQMRAELQkakDMQKSIQNMRNSFSNLE---PDWEIKLGMAQENISLTQTNLRLANVSLSYLEQQAEKEQQVFEV 2357
Cdd:TIGR02168  801 LREALDELRAELT---LLNEEAANLRERLESLErriAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEA 877

                          250       260       270
                   ....*....|....*....|....*....|...
gi 386769627  2358 WNNSMAQQLQQLrdqiAKARHAAEAIDVSLESL 2390
Cdd:TIGR02168  878 LLNERASLEEAL----ALLRSELEELSEELREL 906
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1247-1292 3.32e-05

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 43.50  E-value: 3.32e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 386769627 1247 CSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWGWQAR-LGCR 1292
Cdd:cd00055     4 CNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQgGGCQ 50
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2399-2492 7.34e-05

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 45.49  E-value: 7.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627 2399 LPASYGLSTSNKIRMSFALSNhlESSPLIHLASSE-GRHITLELYKRRVRLVWNLGGTTATVTHPMVVHtrdpkyDDAWY 2477
Cdd:cd00110    12 LPTLPAPRTRLSISFSFRTTS--PNGLLLYAGSQNgGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLN------DGQWH 83

                          90
                  ....*....|....*
gi 386769627 2478 HVEANRTLNLGSLVV 2492
Cdd:cd00110    84 SVSVERNGRSVTLSV 98
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 943-971 2.81e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 40.80  E-value: 2.81e-04
                           10        20
                   ....*....|....*....|....*....
gi 386769627   943 QCPEGYTGDHCQVCDDGYFGNPRQPGSSC 971
Cdd:pfam00053   21 LCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
LamG smart00282
Laminin G domain;
2426-2492 2.85e-04

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 43.10  E-value: 2.85e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386769627   2426 LIHLASSEG-RHITLELYKRRVRLVWNLGGTTATVTHPmvvhtrDPKYDD-AWYHVEANRTLNLGSLVV 2492
Cdd:smart00282   15 LLYAGSKGGgDYLALELRDGRLVLRYDLGSGPARLTSD------PTPLNDgQWHRVAVERNGRSVTLSV 77
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1340-1392 3.47e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 40.37  E-value: 3.47e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 386769627   1340 CGCDAEGSFTQAdgsiaCDS-NGQCPCKSLVVGLKCDTCMQSTFGlsaQNPEGC 1392
Cdd:smart00180    1 CDCDPGGSASGT-----CDPdTGQCECKPNVTGRRCDRCAPGYYG---DGPPGC 46
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2426-2492 4.02e-04

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 42.79  E-value: 4.02e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386769627  2426 LIHLASSEGRHITLELYKRRVRLVWNLGGttatvtHPMVVHTRDPKYDD-AWYHVEANRTLNLGSLVV 2492
Cdd:pfam02210   10 LLYAGGGGSDFLALELVNGRLVLRYDLGS------GPESLLSSGKNLNDgQWHSVRVERNGNTLTLSV 71
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1339-1393 6.59e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 39.64  E-value: 6.59e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 386769627 1339 RCGCDAEGSFtqadgSIACDS-NGQCPCKSLVVGLKCDTCMQSTFGLSAQnPEGCT 1393
Cdd:cd00055     1 PCDCNGHGSL-----SGQCDPgTGQCECKPNTTGRRCDRCAPGYYGLPSQ-GGGCQ 50
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
2178-2390 1.02e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 44.76  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627 2178 LASILA--KERVYEAQRTLYPSDGSSmIERAKHSLHRSKQLQQEALKQMHKSNVLKDKLHRQEQQVEGIKSTIYDSGLRT 2255
Cdd:COG4717    40 LAFIRAmlLERLEKEADELFKPQGRK-PELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREEL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627 2256 NNISGQLQGLSDGSARRQAKDSLEMADRTGEQMRAELQKAKDMQKSIQNMRNSFSNLEpdweiklgmaqenISLTQTNLR 2335
Cdd:COG4717   119 EKLEKLLQLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQ-------------EELEELLEQ 185

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 386769627 2336 LANVSLSYLEQQAEKEQQVfevwnnsmAQQLQQLRDQIAKARHAAEAIDVSLESL 2390
Cdd:COG4717   186 LSLATEEELQDLAEELEEL--------QQRLAELEEELEEAQEELEELEEELEQL 232
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1247-1284 1.08e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 39.22  E-value: 1.08e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 386769627   1247 CSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWG 1284
Cdd:smart00180    3 CDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYG 40
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2008-2312 1.18e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.66  E-value: 1.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  2008 GRLEMLWRDLNQTNHRVVDMRLQVDRVQEVENEAEDvleHVRNLSIRVGESHQELDELNQRISDhldpgyLEQGeglLRL 2087
Cdd:TIGR02168  239 EELEELQEELKEAEEELEELTAELQELEEKLEELRL---EVSELEEEIEELQKELYALANEISR------LEQQ---KQI 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  2088 TVQRQIMLNGHLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAEKHAShLLARSNEYARKFQPTRNGARiamlassahs 2167
Cdd:TIGR02168  307 LRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELES-LEAELEELEAELEELESRLE---------- 375

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  2168 NITEAINDARLASILAKERVYEAQRTLypSDGSSMIERAKHSLHRSKQLQQEALKQMHKSnvlkdKLHRQEQQVEGIKST 2247
Cdd:TIGR02168  376 ELEEQLETLRSKVAQLELQIASLNNEI--ERLEARLERLEDRRERLQQEIEELLKKLEEA-----ELKELQAELEELEEE 448

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 386769627  2248 IYDSGLRTNNISGQLqglsdgsarRQAKDSLEMADRTGEQMRAELQKAKDMQKSIQNMRNSFSNL 2312
Cdd:TIGR02168  449 LEELQEELERLEEAL---------EELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGF 504
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1247-1284 1.43e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 38.87  E-value: 1.43e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 386769627  1247 CSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWG 1284
Cdd:pfam00053    3 CNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYG 40
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 2212-2375 1.73e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 43.86  E-value: 1.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  2212 RSKQLQQEALKQMHKSNVLKDKLHRQEQQVEGIKSTIydsglrtNNISGQLQGLSDgsarRQAKDSLEMADRTGEQMRAE 2291
Cdd:TIGR04523  212 KNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEI-------SNTQTQLNQLKD----EQNKIKKQLSEKQKELEQNN 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627  2292 lQKAKDMQKSIQNMRNSFSNL----EPDW--EIK--LGMAQENISLTQTNLRLANVSLSYLEQQA---EKEQQVFEVWNN 2360
Cdd:TIGR04523  281 -KKIKELEKQLNQLKSEISDLnnqkEQDWnkELKseLKNQEKKLEEIQNQISQNNKIISQLNEQIsqlKKELTNSESENS 359

                          170
                   ....*....|....*
gi 386769627  2361 SMAQQLQQLRDQIAK 2375
Cdd:TIGR04523  360 EKQRELEEKQNEIEK 374
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 401-449 1.79e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 38.49  E-value: 1.79e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 386769627   401 DCNGHAnrSHESPDDPL-MQCICQHNTCGAQCEQCCPLFQDRPYQMGGEC 449
Cdd:pfam00053    2 DCNPHG--SLSDTCDPEtGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
PspA COG1842
Phage shock protein A [Transcription, Signal transduction mechanisms];
2273-2379 4.81e-03

Phage shock protein A [Transcription, Signal transduction mechanisms];


Pssm-ID: 441447 [Multi-domain]  Cd Length: 217  Bit Score: 41.35  E-value: 4.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627 2273 QAKDSLEMADRTGEQMRAELQKAKD-------MQKSIQNMRNSFSNLEPDWEIKLGMAqenisLTQTNLRLAnvsLSYLE 2345
Cdd:COG1842    20 KAEDPEKMLDQAIRDMEEDLVEARQalaqviaNQKRLERQLEELEAEAEKWEEKARLA-----LEKGREDLA---REALE 91

                          90       100       110
                  ....*....|....*....|....*....|....
gi 386769627 2346 QQAEKEQQVfevwnNSMAQQLQQLRDQIAKARHA 2379
Cdd:COG1842    92 RKAELEAQA-----EALEAQLAQLEEQVEKLKEA 120
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1907-2141 5.24e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 42.45  E-value: 5.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627 1907 AVATIGKREFAIKSMREDAVTQQHSVGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQARFYLQAIREHDQMVQGIR-ST 1985
Cdd:COG4717   288 LLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQlEE 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627 1986 NDCAWKHFYAMGNASDAsfDESGRLEMLWRDLNQTNHRVVDMRLQVDRV-------------QEVENEAEDVLEHVRNLS 2052
Cdd:COG4717   368 LEQEIAALLAEAGVEDE--EELRAALEQAEEYQELKEELEELEEQLEELlgeleellealdeEELEEELEELEEELEELE 445

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386769627 2053 IRVGESHQELDELNQRISDhldpgyLEQGEGLLRLTVQRQiMLNGHLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAE 2132
Cdd:COG4717   446 EELEELREELAELEAELEQ------LEEDGELAELLQELE-ELKAELRELAEEWAALKLALELLEEAREEYREERLPPVL 518


                  ....*....
gi 386769627 2133 KHASHLLAR 2141
Cdd:COG4717   519 ERASEYFSR 527
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
401-444 6.66e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 36.91  E-value: 6.66e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 386769627    401 DCNGHANrSHESPDDPLMQCICQHNTCGAQCEQCCPLFQDRPYQ 444
Cdd:smart00180    2 DCDPGGS-ASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPP 44
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 943-972 8.62e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 36.56  E-value: 8.62e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 386769627  943 QCPEGYTGDHCQVCDDGYFGNPRQPGsSCQ 972
Cdd:cd00055    22 ECKPNTTGRRCDRCAPGYYGLPSQGG-GCQ 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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