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Conserved domains on  [gi|17137788|ref|NP_477501|]
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fizzy [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
218-498 7.42e-46

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 165.47  E-value: 7.42e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 218 WSADN--IVAVALGSCVYLWNAQTGniEQLTEFEE-GDYAGSLSWIQEGQILAIGNSTGAVELWDCSKVKRLRVMDGHSA 294
Cdd:COG2319 128 FSPDGktLASGSADGTVRLWDLATG--KLLRTLTGhSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG 205

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 295 RVGSLAW--NSFLVSSGSRDGTIVHHDVRAREHkLSTLSGHTQEVCGLKWSTDFKYLASGGNDNLVNVWSAASGgvgtat 372
Cdd:COG2319 206 AVRSVAFspDGKLLASGSADGTVRLWDLATGKL-LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG------ 278

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 373 DPLHKFNDHQAAVRALAWCPwQPSTLASGGgtADRCIKFWNVNNGTLMKSVDSKS-QVCSLLFSRHYKELISahGFANNQ 451
Cdd:COG2319 279 ELLRTLTGHSGGVNSVAFSP-DGKLLASGS--DDGTVRLWDLATGKLLRTLTGHTgAVRSVAFSPDGKTLAS--GSDDGT 353

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 17137788 452 LTIWKYPTMVKQADLTGHTSRVLQMAMSPDGSTVISAGADETLRLWN 498
Cdd:COG2319 354 VRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
218-498 7.42e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 165.47  E-value: 7.42e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 218 WSADN--IVAVALGSCVYLWNAQTGniEQLTEFEE-GDYAGSLSWIQEGQILAIGNSTGAVELWDCSKVKRLRVMDGHSA 294
Cdd:COG2319 128 FSPDGktLASGSADGTVRLWDLATG--KLLRTLTGhSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG 205

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 295 RVGSLAW--NSFLVSSGSRDGTIVHHDVRAREHkLSTLSGHTQEVCGLKWSTDFKYLASGGNDNLVNVWSAASGgvgtat 372
Cdd:COG2319 206 AVRSVAFspDGKLLASGSADGTVRLWDLATGKL-LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG------ 278

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 373 DPLHKFNDHQAAVRALAWCPwQPSTLASGGgtADRCIKFWNVNNGTLMKSVDSKS-QVCSLLFSRHYKELISahGFANNQ 451
Cdd:COG2319 279 ELLRTLTGHSGGVNSVAFSP-DGKLLASGS--DDGTVRLWDLATGKLLRTLTGHTgAVRSVAFSPDGKTLAS--GSDDGT 353

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 17137788 452 LTIWKYPTMVKQADLTGHTSRVLQMAMSPDGSTVISAGADETLRLWN 498
Cdd:COG2319 354 VRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 216-498 1.26e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 153.64  E-value: 1.26e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 216 MDWSADN--IVAVALGSCVYLWNAQTGniEQLTEFEE-GDYAGSLSWIQEGQILAIGNSTGAVELWDCSKVKRLRVMDGH 292
Cdd:cd00200  15 VAFSPDGklLATGSGDGTIKVWDLETG--ELLRTLKGhTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGH 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 293 SARVGSLAW--NSFLVSSGSRDGTIVHHDVRAREhKLSTLSGHTQEVCGLKWSTDFKYLASGGNDNLVNVWSAASGGvgt 370
Cdd:cd00200  93 TSYVSSVAFspDGRILSSSSRDKTIKVWDVETGK-CLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK--- 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 371 atdPLHKFNDHQAAVRALAWCPwQPSTLASGGGtaDRCIKFWNVNNGTLMKSVDSKSQ-VCSLLFSRHYKELISAHgfAN 449
Cdd:cd00200 169 ---CVATLTGHTGEVNSVAFSP-DGEKLLSSSS--DGTIKLWDLSTGKCLGTLRGHENgVNSVAFSPDGYLLASGS--ED 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 17137788 450 NQLTIWKYPTMVKQADLTGHTSRVLQMAMSPDGSTVISAGADETLRLWN 498
Cdd:cd00200 241 GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 304-498 4.45e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 59.33  E-value: 4.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788  304 FLVSSGSRDGTIVHHDV--RAREHKLStlsghtqevcGLKWSTDFK-YLASGGNDNLVNVWSAASGGVGTatdplhKFND 380
Cdd:PLN00181 510 FECESIIKDGRDIHYPVveLASRSKLS----------GICWNSYIKsQVASSNFEGVVQVWDVARSQLVT------EMKE 573

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788  381 HQAAVRALAWCPWQPSTLASGggTADRCIKFWNVNNGTLMKSVDSKSQVCSLLF-SRHYKELisAHGFANNQLTIW---- 455
Cdd:PLN00181 574 HEKRVWSIDYSSADPTLLASG--SDDGSVKLWSINQGVSIGTIKTKANICCVQFpSESGRSL--AFGSADHKVYYYdlrn 649

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 17137788  456 -KYP--TMVkqadltGHtSRVLQMAMSPDGSTVISAGADETLRLWN 498
Cdd:PLN00181 650 pKLPlcTMI------GH-SKTVSYVRFVDSSTLVSSSTDNTLKLWD 688
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 325-362 9.16e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 9.16e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 17137788    325 HKLSTLSGHTQEVCGLKWSTDFKYLASGGNDNLVNVWS 362
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
327-362 8.45e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 8.45e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 17137788   327 LSTLSGHTQEVCGLKWSTDFKYLASGGNDNLVNVWS 362
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
218-498 7.42e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 165.47  E-value: 7.42e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 218 WSADN--IVAVALGSCVYLWNAQTGniEQLTEFEE-GDYAGSLSWIQEGQILAIGNSTGAVELWDCSKVKRLRVMDGHSA 294
Cdd:COG2319 128 FSPDGktLASGSADGTVRLWDLATG--KLLRTLTGhSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG 205

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 295 RVGSLAW--NSFLVSSGSRDGTIVHHDVRAREHkLSTLSGHTQEVCGLKWSTDFKYLASGGNDNLVNVWSAASGgvgtat 372
Cdd:COG2319 206 AVRSVAFspDGKLLASGSADGTVRLWDLATGKL-LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG------ 278

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 373 DPLHKFNDHQAAVRALAWCPwQPSTLASGGgtADRCIKFWNVNNGTLMKSVDSKS-QVCSLLFSRHYKELISahGFANNQ 451
Cdd:COG2319 279 ELLRTLTGHSGGVNSVAFSP-DGKLLASGS--DDGTVRLWDLATGKLLRTLTGHTgAVRSVAFSPDGKTLAS--GSDDGT 353

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 17137788 452 LTIWKYPTMVKQADLTGHTSRVLQMAMSPDGSTVISAGADETLRLWN 498
Cdd:COG2319 354 VRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 216-498 1.26e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 153.64  E-value: 1.26e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 216 MDWSADN--IVAVALGSCVYLWNAQTGniEQLTEFEE-GDYAGSLSWIQEGQILAIGNSTGAVELWDCSKVKRLRVMDGH 292
Cdd:cd00200  15 VAFSPDGklLATGSGDGTIKVWDLETG--ELLRTLKGhTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGH 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 293 SARVGSLAW--NSFLVSSGSRDGTIVHHDVRAREhKLSTLSGHTQEVCGLKWSTDFKYLASGGNDNLVNVWSAASGGvgt 370
Cdd:cd00200  93 TSYVSSVAFspDGRILSSSSRDKTIKVWDVETGK-CLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK--- 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 371 atdPLHKFNDHQAAVRALAWCPwQPSTLASGGGtaDRCIKFWNVNNGTLMKSVDSKSQ-VCSLLFSRHYKELISAHgfAN 449
Cdd:cd00200 169 ---CVATLTGHTGEVNSVAFSP-DGEKLLSSSS--DGTIKLWDLSTGKCLGTLRGHENgVNSVAFSPDGYLLASGS--ED 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 17137788 450 NQLTIWKYPTMVKQADLTGHTSRVLQMAMSPDGSTVISAGADETLRLWN 498
Cdd:cd00200 241 GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
219-516 1.34e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 156.61  E-value: 1.34e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 219 SADNIVAVALGSCVYLWNAQTGNIEQLTEFEEGDYAGSLSWIQEGQILAIGNSTGAVELWDCSKVKRLRVMDGHSARVGS 298
Cdd:COG2319  46 PDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRS 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 299 LAW--NSFLVSSGSRDGTIVHHDVRAREhKLSTLSGHTQEVCGLKWSTDFKYLASGGNDNLVNVWSAASGgvgtatDPLH 376
Cdd:COG2319 126 VAFspDGKTLASGSADGTVRLWDLATGK-LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG------KLLR 198

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 377 KFNDHQAAVRALAWCPwQPSTLASGGgtADRCIKFWNVNNGTLMKSVDSKS-QVCSLLFSRHYKELISAHgfANNQLTIW 455
Cdd:COG2319 199 TLTGHTGAVRSVAFSP-DGKLLASGS--ADGTVRLWDLATGKLLRTLTGHSgSVRSVAFSPDGRLLASGS--ADGTVRLW 273

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17137788 456 KYPTMVKQADLTGHTSRVLQMAMSPDGSTVISAGADETLRLWNcfapdpLASKKAVSTSKG 516
Cdd:COG2319 274 DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD------LATGKLLRTLTG 328
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 256-498 2.50e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.53  E-value: 2.50e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 256 SLSWIQEGQILAIGNSTGAVELWDCSKVKRLRVMDGHSARVGSLAWNSF--LVSSGSRDGTIVHHDVRAREhKLSTLSGH 333
Cdd:cd00200  14 CVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADgtYLASGSSDKTIRLWDLETGE-CVRTLTGH 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 334 TQEVCGLKWSTDFKYLASGGNDNLVNVWSAASGgvgtatDPLHKFNDHQAAVRALAWCPwqPSTLASGGGtADRCIKFWN 413
Cdd:cd00200  93 TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG------KCLTTLRGHTDWVNSVAFSP--DGTFVASSS-QDGTIKLWD 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 414 VNNGTLMKS-VDSKSQVCSLLFSRHYKELISahGFANNQLTIWKYPTMVKQADLTGHTSRVLQMAMSPDGSTVISAGADE 492
Cdd:cd00200 164 LRTGKCVATlTGHTGEVNSVAFSPDGEKLLS--SSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDG 241


                ....*.
gi 17137788 493 TLRLWN 498
Cdd:cd00200 242 TIRVWD 247
WD40 COG2319
WD40 repeat [General function prediction only];
218-516 7.07e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.95  E-value: 7.07e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 218 WSADNIVAVALGSCVYLWNAQTGNIEQLTEFEEGDYAGSLSWIQEGQILAIGNSTGAVELWDCSKVKRLRVMDGHSARVG 297
Cdd:COG2319   3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 298 SLAWNS--FLVSSGSRDGTIVHHDVRAREHkLSTLSGHTQEVCGLKWSTDFKYLASGGNDNLVNVWSAASGgvgtatDPL 375
Cdd:COG2319  83 SVAFSPdgRLLASASADGTVRLWDLATGLL-LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG------KLL 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 376 HKFNDHQAAVRALAWCPwQPSTLASGGgtADRCIKFWNVNNGTLMKSVD-SKSQVCSLLFSRHYKELISAHgfANNQLTI 454
Cdd:COG2319 156 RTLTGHSGAVTSVAFSP-DGKLLASGS--DDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGS--ADGTVRL 230

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17137788 455 WKYPTMVKQADLTGHTSRVLQMAMSPDGSTVISAGADETLRLWNcfapdpLASKKAVSTSKG 516
Cdd:COG2319 231 WDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD------LATGELLRTLTG 286
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 286-498 1.92e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.13  E-value: 1.92e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 286 LRVMDGHSARVGSLAWN---SFLVsSGSRDGTIVHHDVrAREHKLSTLSGHTQEVCGLKWSTDFKYLASGGNDNLVNVWS 362
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSpdgKLLA-TGSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 363 AASGgvgtatDPLHKFNDHQAAVRALAWCPwqPSTLASGGGtADRCIKFWNVNNGTLMKSVDS-KSQVCSLLFSrHYKEL 441
Cdd:cd00200  80 LETG------ECVRTLTGHTSYVSSVAFSP--DGRILSSSS-RDKTIKVWDVETGKCLTTLRGhTDWVNSVAFS-PDGTF 149

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 17137788 442 ISAhGFANNQLTIWKYPTMVKQADLTGHTSRVLQMAMSPDGSTVISAGADETLRLWN 498
Cdd:cd00200 150 VAS-SSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD 205
WD40 COG2319
WD40 repeat [General function prediction only];
261-519 9.74e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.23  E-value: 9.74e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 261 QEGQILAIGNSTGAVELWDCSKVKRLRVMDGHSARVGSLAWNSF--LVSSGSRDGTIVHHDVRAREhKLSTLSGHTQEVC 338
Cdd:COG2319   4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDgaRLAAGAGDLTLLLLDAAAGA-LLATLLGHTAAVL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 339 GLKWSTDFKYLASGGNDNLVNVWSAASGGvgtatdPLHKFNDHQAAVRALAWCPWQpSTLASGGgtADRCIKFWNVNNGT 418
Cdd:COG2319  83 SVAFSPDGRLLASASADGTVRLWDLATGL------LLRTLTGHTGAVRSVAFSPDG-KTLASGS--ADGTVRLWDLATGK 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 419 LMKSVDS-KSQVCSLLFSRHYKELISAHGfaNNQLTIWKYPTMVKQADLTGHTSRVLQMAMSPDGSTVISAGADETLRLW 497
Cdd:COG2319 154 LLRTLTGhSGAVTSVAFSPDGKLLASGSD--DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231

                       250       260
                ....*....|....*....|..
gi 17137788 498 NcfapdpLASKKAVSTSKGKQS 519
Cdd:COG2319 232 D------LATGKLLRTLTGHSG 247
WD40 COG2319
WD40 repeat [General function prediction only];
216-365 2.62e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.05  E-value: 2.62e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788 216 MDWSADN--IVAVALGSCVYLWNAQTGNIEQLTEfEEGDYAGSLSWIQEGQILAIGNSTGAVELWDCSKVKRLRVMDGHS 293
Cdd:COG2319 252 VAFSPDGrlLASGSADGTVRLWDLATGELLRTLT-GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHT 330

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17137788 294 ARVGSLAW---NSFLVSsGSRDGTIVHHDVRAREhKLSTLSGHTQEVCGLKWSTDFKYLASGGNDNLVNVWSAAS 365
Cdd:COG2319 331 GAVRSVAFspdGKTLAS-GSDDGTVRLWDLATGE-LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 304-498 4.45e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 59.33  E-value: 4.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788  304 FLVSSGSRDGTIVHHDV--RAREHKLStlsghtqevcGLKWSTDFK-YLASGGNDNLVNVWSAASGGVGTatdplhKFND 380
Cdd:PLN00181 510 FECESIIKDGRDIHYPVveLASRSKLS----------GICWNSYIKsQVASSNFEGVVQVWDVARSQLVT------EMKE 573

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788  381 HQAAVRALAWCPWQPSTLASGggTADRCIKFWNVNNGTLMKSVDSKSQVCSLLF-SRHYKELisAHGFANNQLTIW---- 455
Cdd:PLN00181 574 HEKRVWSIDYSSADPTLLASG--SDDGSVKLWSINQGVSIGTIKTKANICCVQFpSESGRSL--AFGSADHKVYYYdlrn 649

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 17137788  456 -KYP--TMVkqadltGHtSRVLQMAMSPDGSTVISAGADETLRLWN 498
Cdd:PLN00181 650 pKLPlcTMI------GH-SKTVSYVRFVDSSTLVSSSTDNTLKLWD 688
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 325-362 9.16e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 9.16e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 17137788    325 HKLSTLSGHTQEVCGLKWSTDFKYLASGGNDNLVNVWS 362
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 266-381 1.63e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.86  E-value: 1.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788  266 LAIGNSTGAVELWDCSKVKRLRVMDGHSARVGSLAWNS---FLVSSGSRDGT---------------------------- 314
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSadpTLLASGSDDGSvklwsinqgvsigtiktkaniccvqfps 627

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137788  315 --------------IVHHDVRAREHKLSTLSGHTQEVCGLKWsTDFKYLASGGNDNLVNVWSAASGGVGTATDPLHKFND 380
Cdd:PLN00181 628 esgrslafgsadhkVYYYDLRNPKLPLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDLSMSISGINETPLHSFMG 706


                 .
gi 17137788  381 H 381
Cdd:PLN00181 707 H 707
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 459-498 3.15e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 3.15e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 17137788    459 TMVKQADLTGHTSRVLQMAMSPDGSTVISAGADETLRLWN 498
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
327-362 8.45e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 8.45e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 17137788   327 LSTLSGHTQEVCGLKWSTDFKYLASGGNDNLVNVWS 362
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
466-498 1.15e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.15e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 17137788   466 LTGHTSRVLQMAMSPDGSTVISAGADETLRLWN 498
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 374-413 1.28e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.28e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 17137788    374 PLHKFNDHQAAVRALAWCPWQpSTLASGGgtADRCIKFWN 413
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDG-KYLASGS--DDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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