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Conserved domains on  [gi|71989053|ref|NP_490909|]
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Galactokinase [Caenorhabditis elegans]

Protein Classification

galactokinase family protein( domain architecture ID 1004942)

galactokinase family protein such as galactokinase that catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

CATH:  1.20.1440.340|3.30.230.10|3.30.70.3170
EC:  2.7.1.-
Gene Ontology:  GO:0005524|GO:0004335|GO:0005975
PubMed:  26862196|15526155

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN02521 super family cl33510
galactokinase
 5-409 6.11e-102

galactokinase


The actual alignment was detected with superfamily member PLN02521:

Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 312.03  E-value: 6.11e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053    5 EQLAEQFVKLYGIEPEVRVTCPGRVNLIGEHIDYHDYGVFPMAIdAATTILAAKNDTNS--IVFSNFDSKYESWSSPIpC 82
Cdd:PLN02521  33 ARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAI-RQDTIVAIRRAEGSkkLRIANVNDKYTTCTFPA-D 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053   83 PWKGC--TSPKWFDYLLCGWRGIM-----NREDGQEQFGMSFLLYGTIPPSSGLSSSSSLVCASALATLSLIVDNDPfeh 155
Cdd:PLN02521 111 PDQEVdlANHKWGNYFICGYKGVFeflksKGVDVGPPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFT--- 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  156 isRKDFAHLCIESEPLIGTLSGGMDQAAEVLASEGTALRIDFNPLRSKNIQLPSDAVFVVVHSNTELNKGATSH--YNER 233
Cdd:PLN02521 188 --KKEVAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNR 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  234 VIEGRIVAQIFKQKFNITS----GSFR-LKEIQTLSG------KSFKEILKIVEELPDEVNKEQVIDLIGADKLEECLTE 302
Cdd:PLN02521 266 VVECRLAAIVLAVKLGMSAeeaiSKVKtLSDVEGLCVsfagshGSSDPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  303 NTRSF------QKFKLRPRARHVFSEAYRVEQFESACAQK-----NIQEMGRLMNESHRSCAIDYECSCRELDEICRLYL 371
Cdd:PLN02521 346 SPTSLavlkaaKHFKLHQRAVHVYSEAKRVHAFRDTVSSSlseeeKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCR 425

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 71989053  372 DHGALGARLTGAGWGGCAVVLMAADDVDRVVAELPSLF 409
Cdd:PLN02521 426 DNGALGARLTGAGWGGCAVALVKEAIVPQFILALKEKF 463
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 5-409 6.11e-102

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 312.03  E-value: 6.11e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053    5 EQLAEQFVKLYGIEPEVRVTCPGRVNLIGEHIDYHDYGVFPMAIdAATTILAAKNDTNS--IVFSNFDSKYESWSSPIpC 82
Cdd:PLN02521  33 ARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAI-RQDTIVAIRRAEGSkkLRIANVNDKYTTCTFPA-D 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053   83 PWKGC--TSPKWFDYLLCGWRGIM-----NREDGQEQFGMSFLLYGTIPPSSGLSSSSSLVCASALATLSLIVDNDPfeh 155
Cdd:PLN02521 111 PDQEVdlANHKWGNYFICGYKGVFeflksKGVDVGPPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFT--- 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  156 isRKDFAHLCIESEPLIGTLSGGMDQAAEVLASEGTALRIDFNPLRSKNIQLPSDAVFVVVHSNTELNKGATSH--YNER 233
Cdd:PLN02521 188 --KKEVAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNR 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  234 VIEGRIVAQIFKQKFNITS----GSFR-LKEIQTLSG------KSFKEILKIVEELPDEVNKEQVIDLIGADKLEECLTE 302
Cdd:PLN02521 266 VVECRLAAIVLAVKLGMSAeeaiSKVKtLSDVEGLCVsfagshGSSDPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  303 NTRSF------QKFKLRPRARHVFSEAYRVEQFESACAQK-----NIQEMGRLMNESHRSCAIDYECSCRELDEICRLYL 371
Cdd:PLN02521 346 SPTSLavlkaaKHFKLHQRAVHVYSEAKRVHAFRDTVSSSlseeeKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCR 425

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 71989053  372 DHGALGARLTGAGWGGCAVVLMAADDVDRVVAELPSLF 409
Cdd:PLN02521 426 DNGALGARLTGAGWGGCAVALVKEAIVPQFILALKEKF 463
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
5-421 3.52e-79

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 249.30  E-value: 3.52e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053   5 EQLAEQFVKLYGIEPEVRVTCPGRVNLIGEHIDYHDyG-VFPMAIDAATTILAAKNDTNSI-VFS-NFDSKYE-SWSSPI 80
Cdd:COG0153   3 ERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNG-GfVLPAAIDRGTYAAARPRDDRKVrVYSaDFDEEVEfDLDDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  81 PCPwkgctSPKWFDYLlcgwRGIMN--REDGQEQFGMSFLLYGTIPpssglssssslVCA----SA---LATLSLIvdND 151
Cdd:COG0153  82 PGE-----EDGWANYV----RGVAWalQERGYKLGGFDLVIDGDVP-----------LGAglssSAaleVAVALAL--ND 139

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053 152 PFE-HISRKDFAHLCIESE-PLIGTLSGGMDQAAEVLASEGTALRIDFNPLRSKNIQLP-SDAVFVVVHSNTELNKgATS 228
Cdd:COG0153 140 LFGlGLDPVELAKIGQRAEnEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPlEGYALVIVDTNVKHSL-ADS 218

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053 229 HYNERVIEGRIVAQIFKQKFnitsgsfrLKEIqtlsgkSFKEILKIVEELPDEVnkeqvidligadkleecltentrsfq 308
Cdd:COG0153 219 EYNERRAECEAAAAILGVKS--------LRDV------TLEDLEAARARLGDEV-------------------------- 258

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053 309 kfkLRPRARHVFSEAYRVEQFESACAQKNIQEMGRLMNESHRSCAIDYECSCRELDEICRLYLDH-GALGARLTGAGWGG 387
Cdd:COG0153 259 ---LRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEaGVLGARMTGGGFGG 335

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*
gi 71989053 388 CAVVLMAADDVDRVVAEL-----------PSLFVSKPAQGIRLQR 421
Cdd:COG0153 336 CTIALVPKDAVDEFIEAVaeayaektglePDFYVVKPSDGARRLA 380
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 5-401 8.82e-61

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 201.98  E-value: 8.82e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053     5 EQLAEQFVKLYGIEPEVRVTCPGRVNLIGEHIDYHDYGVFPMAIDAATTILAAK-NDTN-SIVFSNFDSKYESWSSPIPC 82
Cdd:TIGR00131   2 ESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVrDDKNvRIYLANADNKFAERSLDLPL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053    83 PwkGCTSPKWFDYLLCGWRGIMNREDGQEQfGMSFLLYGTIPPSSGLSSSSSLVCASALATLSLivdnDPFEHISRKDFA 162
Cdd:TIGR00131  82 D--GSEVSDWANYFKGVLHVAQERFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVGAVLQNM----GHLPLDSKQILL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053   163 HLCIESEPLIGTLSGGMDQAAEVLASEGTALRIDFNPLRSKNIQLP-SDAVFVVVHSNTELNKgATSHYNERVIEGRIVA 241
Cdd:TIGR00131 155 RIQVAENHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPqLGIAFVIANTNVKRTL-APSNYNTRRQECTTAA 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053   242 QIFKQKFNITSGSFRLKEIQTLSGKSFKeILKIVEElpdevnkeqvidligadkleecltentrsfqkfklrpRARHVFS 321
Cdd:TIGR00131 234 NFLAATDKGALRDFMNEYFARYIARLTK-MLPLVEE-------------------------------------RAKHVVS 275

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053   322 EAYRVEQFESACAQKNIQEMGRLMNESHRSCAIDYECSCRELDE-ICRLYLDHGALGARLTGAGWGGCAVVLMAADDVDR 400
Cdd:TIGR00131 276 ENLRVLKAVKAMKDNDFKQFGALMNESHASCDDDYECTCPEIDElVCSAALVNGSGGSRMTGAGFGGCTVHLVPNENVDK 355


                  .
gi 71989053   401 V 401
Cdd:TIGR00131 356 V 356
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 9-58 1.85e-19

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 81.34  E-value: 1.85e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 71989053     9 EQFVKLYGIEPEVRVTCPGRVNLIGEHIDYHDYGVFPMAIDAATTILAAK 58
Cdd:pfam10509   1 EAFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 5-409 6.11e-102

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 312.03  E-value: 6.11e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053    5 EQLAEQFVKLYGIEPEVRVTCPGRVNLIGEHIDYHDYGVFPMAIdAATTILAAKNDTNS--IVFSNFDSKYESWSSPIpC 82
Cdd:PLN02521  33 ARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAI-RQDTIVAIRRAEGSkkLRIANVNDKYTTCTFPA-D 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053   83 PWKGC--TSPKWFDYLLCGWRGIM-----NREDGQEQFGMSFLLYGTIPPSSGLSSSSSLVCASALATLSLIVDNDPfeh 155
Cdd:PLN02521 111 PDQEVdlANHKWGNYFICGYKGVFeflksKGVDVGPPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFT--- 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  156 isRKDFAHLCIESEPLIGTLSGGMDQAAEVLASEGTALRIDFNPLRSKNIQLPSDAVFVVVHSNTELNKGATSH--YNER 233
Cdd:PLN02521 188 --KKEVAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNR 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  234 VIEGRIVAQIFKQKFNITS----GSFR-LKEIQTLSG------KSFKEILKIVEELPDEVNKEQVIDLIGADKLEECLTE 302
Cdd:PLN02521 266 VVECRLAAIVLAVKLGMSAeeaiSKVKtLSDVEGLCVsfagshGSSDPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  303 NTRSF------QKFKLRPRARHVFSEAYRVEQFESACAQK-----NIQEMGRLMNESHRSCAIDYECSCRELDEICRLYL 371
Cdd:PLN02521 346 SPTSLavlkaaKHFKLHQRAVHVYSEAKRVHAFRDTVSSSlseeeKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCR 425

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 71989053  372 DHGALGARLTGAGWGGCAVVLMAADDVDRVVAELPSLF 409
Cdd:PLN02521 426 DNGALGARLTGAGWGGCAVALVKEAIVPQFILALKEKF 463
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
5-421 3.52e-79

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 249.30  E-value: 3.52e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053   5 EQLAEQFVKLYGIEPEVRVTCPGRVNLIGEHIDYHDyG-VFPMAIDAATTILAAKNDTNSI-VFS-NFDSKYE-SWSSPI 80
Cdd:COG0153   3 ERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNG-GfVLPAAIDRGTYAAARPRDDRKVrVYSaDFDEEVEfDLDDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  81 PCPwkgctSPKWFDYLlcgwRGIMN--REDGQEQFGMSFLLYGTIPpssglssssslVCA----SA---LATLSLIvdND 151
Cdd:COG0153  82 PGE-----EDGWANYV----RGVAWalQERGYKLGGFDLVIDGDVP-----------LGAglssSAaleVAVALAL--ND 139

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053 152 PFE-HISRKDFAHLCIESE-PLIGTLSGGMDQAAEVLASEGTALRIDFNPLRSKNIQLP-SDAVFVVVHSNTELNKgATS 228
Cdd:COG0153 140 LFGlGLDPVELAKIGQRAEnEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPlEGYALVIVDTNVKHSL-ADS 218

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053 229 HYNERVIEGRIVAQIFKQKFnitsgsfrLKEIqtlsgkSFKEILKIVEELPDEVnkeqvidligadkleecltentrsfq 308
Cdd:COG0153 219 EYNERRAECEAAAAILGVKS--------LRDV------TLEDLEAARARLGDEV-------------------------- 258

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053 309 kfkLRPRARHVFSEAYRVEQFESACAQKNIQEMGRLMNESHRSCAIDYECSCRELDEICRLYLDH-GALGARLTGAGWGG 387
Cdd:COG0153 259 ---LRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEaGVLGARMTGGGFGG 335

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*
gi 71989053 388 CAVVLMAADDVDRVVAEL-----------PSLFVSKPAQGIRLQR 421
Cdd:COG0153 336 CTIALVPKDAVDEFIEAVaeayaektglePDFYVVKPSDGARRLA 380
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 5-401 8.82e-61

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 201.98  E-value: 8.82e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053     5 EQLAEQFVKLYGIEPEVRVTCPGRVNLIGEHIDYHDYGVFPMAIDAATTILAAK-NDTN-SIVFSNFDSKYESWSSPIPC 82
Cdd:TIGR00131   2 ESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVrDDKNvRIYLANADNKFAERSLDLPL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053    83 PwkGCTSPKWFDYLLCGWRGIMNREDGQEQfGMSFLLYGTIPPSSGLSSSSSLVCASALATLSLivdnDPFEHISRKDFA 162
Cdd:TIGR00131  82 D--GSEVSDWANYFKGVLHVAQERFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVGAVLQNM----GHLPLDSKQILL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053   163 HLCIESEPLIGTLSGGMDQAAEVLASEGTALRIDFNPLRSKNIQLP-SDAVFVVVHSNTELNKgATSHYNERVIEGRIVA 241
Cdd:TIGR00131 155 RIQVAENHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPqLGIAFVIANTNVKRTL-APSNYNTRRQECTTAA 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053   242 QIFKQKFNITSGSFRLKEIQTLSGKSFKeILKIVEElpdevnkeqvidligadkleecltentrsfqkfklrpRARHVFS 321
Cdd:TIGR00131 234 NFLAATDKGALRDFMNEYFARYIARLTK-MLPLVEE-------------------------------------RAKHVVS 275

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053   322 EAYRVEQFESACAQKNIQEMGRLMNESHRSCAIDYECSCRELDE-ICRLYLDHGALGARLTGAGWGGCAVVLMAADDVDR 400
Cdd:TIGR00131 276 ENLRVLKAVKAMKDNDFKQFGALMNESHASCDDDYECTCPEIDElVCSAALVNGSGGSRMTGAGFGGCTVHLVPNENVDK 355


                  .
gi 71989053   401 V 401
Cdd:TIGR00131 356 V 356
PRK03817 PRK03817
galactokinase; Provisional
 22-418 1.18e-49

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 171.72  E-value: 1.18e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053   22 RVTCPGRVNLIGEHIDYHDYGVFPMAIDAATTILAAKNDtNSIVFS-NFDSKYESWSSPIPcpwkgcTSPKWFDYLlcgw 100
Cdd:PRK03817   2 KVKSPGRVNLIGEHTDYNDGYVLPFAINLYTFLEIEKSE-KFIFYSeNFNEEKTFELDKLE------KLNSWADYI---- 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  101 RGIMN--REDGQEQFGMSFLLYGTIPpssglssSSSLVCASA---LATLSLIvdNDPFE-HISRKDFAHLCIESE-PLIG 173
Cdd:PRK03817  71 KGVIWvlEKRGYEVGGVKGKVSSNLP-------IGAGLSSSAsleVAVAYAL--NEAYNlNLSKLELALLAREAEnEFVG 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  174 TLSGGMDQAAEVLASEGTALRIDFNPLRSKNIQLPSDAVFVVVHSNT--ELnkgATSHYNERViegRIVAQIFKqkfnit 251
Cdd:PRK03817 142 VPCGIMDQFAVAFGKKDHAIFLDTMTLEYEYVPFPEDYEILVFDTGVkrEL---ASSEYNERR---QECEEALK------ 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  252 sgsfrlkeiqTLSGKSFKeilkiveelpdEVNKEQVidligaDKLEEcltentrsfqkfKLRPRARHVFSEAYRVEQFES 331
Cdd:PRK03817 210 ----------ILGKKSSK-----------EVTEEDL------SKLPP------------LLRKRAGYVLRENERVLKVRD 250

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  332 ACAQKNIQEMGRLMNESHRSCAIDYECSCRELDEICRLYLDHGALGARLTGAGWGGCAVVLMAADDVDRVVAEL------ 405
Cdd:PRK03817 251 ALKEGDIETLGELLTESHWDLADNYEVSCEELDFFVEFALELGAYGARLTGAGFGGSAIALVDKGKFESIGEELleeykk 330

                        410
                 ....*....|....*...
gi 71989053  406 -----PSLFVSKPAQGIR 418
Cdd:PRK03817 331 rfgidPKYFVVESSDGVR 348
PRK05322 PRK05322
galactokinase; Provisional
 5-399 1.73e-42

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 153.48  E-value: 1.73e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053    5 EQLAEQFVKLYGIEPEVRVTCPGRVNLIGEHIDYHDYGVFPMAIDAATTILAAKNDTN-------------SIVFSNFDS 71
Cdd:PRK05322   4 EELKKKFAEVFGEEAEDVFFSPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKkvrlysanfedlgIIEFDLDDL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053   72 KYESwsspipcpwkgctSPKWFDYLlcgwRGIMN--REDGQE-QFGMSFLLYGTIPPssglssssslvcASAL---ATLS 145
Cdd:PRK05322  84 SFDK-------------EDDWANYP----KGVLKflQEAGYKiDHGFDILIYGNIPN------------GAGLsssASIE 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  146 L---IVDNDPFE-HISRKDFAHLCIESE-PLIGTLSGGMDQAAEVLASEGTALRIDFN-------PLRSKNiqlpsdavF 213
Cdd:PRK05322 135 LltgVILKDLFNlDLDRLELVKLGQKTEnEFIGVNSGIMDQFAIGMGKKDHAILLDCNtleyeyvPLDLGD--------Y 206

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  214 VVVHSNTelNKG---ATSHYNERVIEGRIVAQIFKQKFNITSgsfrLKEIQtlsgksfkeilkiVEELpdevnkEQVIDL 290
Cdd:PRK05322 207 VIVIMNT--NKRrelADSKYNERRAECEKALEELQKKLDIKS----LGELT-------------EEEF------DEYSYL 261

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  291 IGADKLeecltentrsfqkfklRPRARHVFSEAYRVEQFESACAQKNIQEMGRLMNESHRSCAIDYECSCRELDEICRLY 370
Cdd:PRK05322 262 IKDETL----------------LKRARHAVTENQRTLKAVKALKAGDLEKFGRLMNASHVSLRDDYEVTGLELDTLVEAA 325

                        410       420       430
                 ....*....|....*....|....*....|
gi 71989053  371 LDH-GALGARLTGAGWGGCAVVLMAADDVD 399
Cdd:PRK05322 326 WKQeGVLGARMTGAGFGGCAIAIVKKDKVE 355
PRK05101 PRK05101
galactokinase; Provisional
 1-416 1.54e-37

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 140.06  E-value: 1.54e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053    1 MVSNEQLAEQFVKLYGIEPEVRVTCPGRVNLIGEHIDYHDYGVFPMAIDAATTILAAKNDTNSI--VFSNFDSKYESWS- 77
Cdd:PRK05101   1 MSLKQKTQSLFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRIVrvIAADYDNQQDEFSl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053   78 -SPI-PCPwkgctSPKWFDYLlcgwRGIMN--REDGQEQFGMSFLLYGTIPPSSGLssssslvcaSALATLSLIV----- 148
Cdd:PRK05101  81 dAPIvPHP-----EQQWANYV----RGVVKhlQERNPDFGGADLVISGNVPQGAGL---------SSSASLEVAVgqtfq 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  149 --DNDPfehISRKDFAHLCIESE-PLIGTLSGGMDQAAEVLASEGTALRIDFNPLRSKNIQLPSDAVFVVVHSNTElnKG 225
Cdd:PRK05101 143 qlYHLP---LSGAEIALNGQEAEnQFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPMPEGVAVVIINSNVK--RG 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  226 -ATSHYNERVIEGRIVAQIFKQKfnitsgsfrlkeiqTLSGKSFKEILKIVEELPDEVNKeqvidligadkleecltent 304
Cdd:PRK05101 218 lVDSEYNTRRQQCETAARFFGVK--------------ALRDVTLEQFNAVAAELDPVVAK-------------------- 263

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  305 rsfqkfklrpRARHVFSEAYRVEQFESACAQKNIQEMGRLMNESHRSCAIDYECSCRELD---EICRLYL-DHGalGARL 380
Cdd:PRK05101 264 ----------RARHVITENARTLEAASALAAGDLKRMGELMAESHASMRDDFEITVPQIDtlvEIVKAVIgDQG--GVRM 331

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 71989053  381 TGAGWGGCAVVLMAADDVDRV---VAEL--------PSLFVSKPAQG 416
Cdd:PRK05101 332 TGGGFGGCIVALVPEELVEAVrqaVAEQyeaktglkETFYVCKASQG 378
PRK00555 PRK00555
galactokinase; Provisional
 21-411 1.04e-27

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 112.65  E-value: 1.04e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053   21 VRVTCPGRVNLIGEHIDYHDYGVFPMAIDAATTILAAKNDTNSIVFSnfdSKYESWSSPIPCPwkgcTSPKwfdyLLCGW 100
Cdd:PRK00555   3 VRYAAPGRINLIGEHTDYNLGFALPIALPQRTVVTFTPEHTDAITAS---SDRADGSARIPLD----TTPG----QVTGW 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  101 RGIMN------REDGQEQFGMSFLLYGTIPPSSGLSSSSSLVCAsalaTLSLIVDNDPFEhISRKDFAHL--CIESEpLI 172
Cdd:PRK00555  72 AAYAAgviwalRGAGHPVPGGAMSITSDVEIGSGLSSSAALECA----VLGAVGAATGTR-IDRLEQARLaqRAENE-YV 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  173 GTLSGGMDQAAEVLASEGTALRIDFNPLRSKNIQLPSDA---VFVVVHSNTELNKGATSHYNERVIEGRIVAQIfkqkfn 249
Cdd:PRK00555 146 GAPTGLLDQLAALFGAPKTALLIDFRDLTVRPVAFDPDAagvVLLLMDSRARHRHAGGEYAARRASCERAAADL------ 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  250 itsGSFRLKEIQtlsgksfkeilkiveelpdevnkeqvidligadklEECLTENTRSFQKFKLRpRARHVFSEAYRVEQF 329
Cdd:PRK00555 220 ---GVSSLRAVQ-----------------------------------DRGLAALGAIADPIDAR-RARHVLTENQRVLDF 260

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  330 ESACAQKNIQEMGRLMNESHRSCAIDYECSCRELDEICRLYLDHGALGARLTGAGWGGCAVVLMAADDVDRVVAELPSLF 409
Cdd:PRK00555 261 AAALADSDFTAAGQLLTASHASMRDDFEITTERIDLIADSAVRAGALGARMTGGGFGGCVIALVPADRAEDVADTVRRAA 340


                 ..
gi 71989053  410 VS 411
Cdd:PRK00555 341 VT 342
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 9-58 1.85e-19

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 81.34  E-value: 1.85e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 71989053     9 EQFVKLYGIEPEVRVTCPGRVNLIGEHIDYHDYGVFPMAIDAATTILAAK 58
Cdd:pfam10509   1 EAFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
PLN02865 PLN02865
galactokinase
 6-404 3.84e-16

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 79.85  E-value: 3.84e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053    6 QLAEQFVKLYGIEP-EVRVT-CPGRVNLIGEHIDYHDYGVFPMAIDAATTI-LAAKNDTNSIVFS-NFDS----KYESWS 77
Cdd:PLN02865  14 EIRERVAAMSGRNSgEVRVVvSPYRICPLGAHIDHQGGTVSAMTINKGILLgFVPSGDPEVLLRSaQFEGevrfRVDEIQ 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053   78 SPIPCPWKGC-TSPKWFDY--------------LLCGWRGIMNREDGQEQFGMSfllygtippssglssssslvcASALA 142
Cdd:PLN02865  94 HPIANVSSDSkEESNWGDYargavyalqsrghaLSQGITGYISGSEGLDSSGLS---------------------SSAAV 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  143 TLSLIVdndPFEH-----ISRKDFAHL--CIESEPLiGTLSGGMDQAAEVLASEGTALRIDFNPLRSKNIQLP-----SD 210
Cdd:PLN02865 153 GVAYLL---ALENannltVSPEDNIELdrLIENEYL-GLRNGILDQSAILLSRYGCLTFMDCKTLDHKLVSLQfqqpgGE 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  211 AVFVVVHSNTELNKGATSH--YNERVIEGRIVAQIfkqkfnitsgsfrlkeIQTLSGKSFKE-ILKIVEELPDEVNKEqv 287
Cdd:PLN02865 229 KPFKILLAFSGLRHALTNKpgYNLRVSECQEAARF----------------LLEASGNDELEpLLCNVEPEVYEAHKC-- 290

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  288 idligadKLEECLTEntrsfqkfklrpRARHVFSEAYRVEQFESACAQKNIQEMGRLMNESHRSCAIDYECSCRELDEIC 367
Cdd:PLN02865 291 -------KLEAVLAR------------RAEHYFSENMRVIKGVEAWASGNLEEFGKLISASGLSSIENYECGCEPLIQLY 351

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 71989053  368 RLYLDH-GALGARLTGAGWGGCAVVL----MAADDVDRVVAE 404
Cdd:PLN02865 352 EILLKApGVYGARFSGAGFRGCCVAFvdaeMAEEAASFVRDE 393
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 326-392 6.41e-12

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 65.63  E-value: 6.41e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71989053 326 VEQFESACAQKNIQEMGRLMNESHRS-CAIDYecSCRELDEICRLYLDHGALGARLTGAGWGGCAVVL 392
Cdd:COG1577 211 VEEAIEALEEGDLEALGELMNENHGLlRALGV--STPELDRLVEAARKAGALGAKLTGAGGGGCVIAL 276
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 329-410 1.31e-10

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 57.48  E-value: 1.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053   329 FESACAQKNIQEMGRLMNESHRSC--AIDYECSCRELDEICRLYLDHGaLGARLTGAGWGGCAVVLMA-ADDVDRVVAEL 405
Cdd:pfam08544   1 LLEALLRGDLEELGKLLTESAESLepLLVVGILPPELDELLEALLELG-LGAKLSGSGGGPTVFALFKdEDDAEEVARAL 79


                  ....*
gi 71989053   406 PSLFV 410
Cdd:pfam08544  80 REAGK 84
PTZ00290 PTZ00290
galactokinase; Provisional
 6-412 2.04e-10

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 62.15  E-value: 2.04e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053    6 QLAEQFVKLYGIEPEVRVT------CPGRVNLIGEHIDYHDYGVFPMAIDAATTILAAKN---DTNSIVFSNFDSKY--- 73
Cdd:PTZ00290  17 TLKPIFLETFKVENDADVEwllftfAPGRVNFIGEHVDYMGGYVCPAAVLEGCHILVGRVkhfCDHKLRFATETDEHfvl 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053   74 ---------ESWSSPIpcpwKGCTSPKwfdyllcgwrgiMNRE----DGQEQFGMSFLLYGTIPpssglssSSSLVCASA 140
Cdd:PTZ00290  97 dhlggakhnKAWTTFV----RGAATLR------------LNRLgvaiDAPSLQGVCMVVHGTLP-------MGAGMSASA 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  141 LATLSLI----------VDNDPF---------------EHISRKDFAHLcIESEpLIGTLSGGMDQAAEVLASEGTALRI 195
Cdd:PTZ00290 154 SFGVALLnaintvvtrrYKGCPTspgrrysilppmskeELIELAKQARR-IETE-FCGVNVGIMDQFISAFAEEDKFMFL 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  196 DFNPLRSKNIQLP----SDAVFVVVHS--NTELNKGATSHYNE-RVIEGRIVAQIFKQKFNitsgsfrlkeiqtlsGK-- 266
Cdd:PTZ00290 232 DCKSLTFESHDMTpllgDGACFLLIDSmiKHDLLGGTAGMYNTvRSDQEGAQKKIGKHRYR---------------GKpf 296

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  267 SFKEILKIVEELPDEVNKEQVIdligadklEECLTENTRSfqKFKlrpRARHVFSEAYRVEQFESAC-------AQKNIQ 339
Cdd:PTZ00290 297 TFSDLVRNPKKYTFDGDVVAFM--------ESCKPLMTPG--EFE---RGTYNIMEQIRTLEFIKLNdpelplsREERFR 363

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71989053  340 EMGRLMNESHRSCAIDYECSCRELDEICRLY-LDHGALGARLTGAGWGGCAVVLMAADDVDRVVAELPSLFVSK 412
Cdd:PTZ00290 364 KAGEILNAGHQGMRDLMKITTPELDFIHELInEEKGVAGGRMMGGGFGGCIILLLKKNAVDRVVAHVREKFKAR 437
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 326-392 4.96e-10

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 60.00  E-value: 4.96e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 71989053   326 VEQFESACAQKNIQEMGRLMNESHrSCAIDYECSCRELDEICRLYLDHGALGARLTGAGWGGCAVVL 392
Cdd:TIGR00549 208 TLEAKAALQDGDVESLGELMNINQ-GLLKALGVSHPKLDQLVEIARKAGALGAKLTGAGGGGCMIAL 273
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 326-402 5.09e-10

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 60.64  E-value: 5.09e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71989053  326 VEQFESACAQKNIQEMGRLMNESHRSCAiDYECSCRELDEICRLYLDHGALGARLTGAGWGGCAVVLMAA-DDVDRVV 402
Cdd:PTZ00298 227 VSEAKEALQKGNLFRVGELMNANHDLCQ-KLTVSCRELDSIVQTCRTYGALGAKMSGTGRGGLVVALAASeDQRDAIA 303
PRK03926 PRK03926
mevalonate kinase; Provisional
 326-420 7.10e-07

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 50.44  E-value: 7.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053  326 VEQFESACAQKNIQEMGRLMNESHRSC-AIDyeCSCRELDEICRLYLDHGALGARLTGAGWGGCAVVLMAADDVDRVVAE 404
Cdd:PRK03926 201 SEKGEELILSGDYVSLGELMNINQGLLdALG--VSTKELSELIYAARTAGALGAKITGAGGGGCMVALAAPEKQSEVATA 278

                         90       100
                 ....*....|....*....|.
gi 71989053  405 LPSL----FVSKP-AQGIRLQ 420
Cdd:PRK03926 279 IKIAggkpIITKItDEGLRIE 299
COG2605 COG2605
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction ...
 326-405 5.53e-06

Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only];


Pssm-ID: 442017 [Multi-domain]  Cd Length: 328  Bit Score: 47.87  E-value: 5.53e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989053 326 VEQFESACAQKNIQEMGRLMNES-----HRSCAIdyecSCRELDEICRLYLDHGALGARLTGAGWGGCAVVLMAADDVDR 400
Cdd:COG2605 227 ALEMKEALLKGDLDEFGELLNEGwelkkRLASGI----SNPAIDEIYELARKAGALGGKLLGAGGGGFLLFYAPPERREA 302


                ....*
gi 71989053 401 VVAEL 405
Cdd:COG2605 303 VREAL 307
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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