|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00399 |
PTZ00399 |
cysteinyl-tRNA-synthetase; Provisional |
15-753 |
0e+00 |
|
cysteinyl-tRNA-synthetase; Provisional
Pssm-ID: 240402 [Multi-domain] Cd Length: 651 Bit Score: 755.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 15 HWDQP-KNATPPPQLTVYNSLTRQKEVFVPNEGKRVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRDYFGYDVEFIMN 93
Cdd:PTZ00399 26 EWKKPsKEGKYLTGLKVNNSLTGGKVEFVPQNGRQVRWYTCGPTVYDSSHLGHARTYVTFDIIRRILEDYFGYDVFYVMN 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 94 ITDVDDKIIKRARQSHLlksyfnesqappvmkvcedvvaalehfktkfetemdpdkkkmfevmikkvqqqssaleeamka 173
Cdd:PTZ00399 106 ITDIDDKIIKRAREEKL--------------------------------------------------------------- 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 174 qdsiateeakgrllnesrdvlsewldhnhgkdvrdhSVFDDLAKTYEKEFLADMARLNVLPVDVLTRVSEYVPEVITYVK 253
Cdd:PTZ00399 123 ------------------------------------SIFLELARKWEKEFFEDMKALNVRPPDVITRVSEYVPEIVDFIQ 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 254 KIISNGYAYAAEdGSVYFDTKAFEQNpKHFYAKLVPEAYGEDSEqllknMKESEGELSMSDdrlKSKRSPNDFALWKSSK 333
Cdd:PTZ00399 167 KIIDNGFAYESN-GSVYFDVEAFRKA-GHVYPKLEPESVADEDR-----IAEGEGALGKVS---GEKRSPNDFALWKASK 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 334 DGEPFWPSEWGNGRPGWHIECSVMSSAICGSKLDIHAGGFDLKFPHHDNEIAQVEAHYDDPHWVNYFLHCGTLRIQGMKM 413
Cdd:PTZ00399 237 PGEPSWDSPWGKGRPGWHIECSAMASNILGDPIDIHSGGIDLKFPHHDNELAQSEAYFDKHQWVNYFLHSGHLHIKGLKM 316
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 414 SKSLKNFITIRKALEDYTPRQLRLLFLMHNWADVLDYSSSTMERALQFEKITNEFFLLVKDFLRRHYKpdrsEGYQKFQG 493
Cdd:PTZ00399 317 SKSLKNFITIRQALSKYTARQIRLLFLLHKWDKPMNYSDESMDEAIEKDKVFFNFFANVKIKLRESEL----TSPQKWTQ 392
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 494 KELKLMEEFGKLKSEVHEALCDSVDTRSVIEKFRELISLGNAYIVEKEKeghvPNCLLLRNIAAYITNLLKIFGAIPQSn 573
Cdd:PTZ00399 393 HDFELNELFEETKSAVHAALLDNFDTPEALQALQKLISATNTYLNSGEQ----PSAPLLRSVAQYVTKILSIFGLVEGS- 467
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 574 qeigfvsedecNGEGASTSFNKEAVVMPYLDALAQFREKVRLIAKEHKVN--------GILEECDTLRDKTLTELGVRLE 645
Cdd:PTZ00399 468 -----------DGLGSQGQNSTSENFKPLLEALLRFRDEVRDAAKAEMKLisldkkkkQLLQLCDKLRDEWLPNLGIRIE 536
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 646 DR-NGQTVVKLVDRATLLREQEQKDTEKKRKDKEKADKEQKAREKADKEAAAKKIKPEELFKQGEhvGKYSKFDERGVPT 724
Cdd:PTZ00399 537 DKpDGPSVWKLDDKEELQREKEEKEALKEQKRLRKLKKQEEKKKKELEKLEKAKIPPAEFFKRQE--DKYSAFDETGLPT 614
|
730 740
....*....|....*....|....*....
gi 2220285674 725 HLADGTEITKSQIKKLEKVYEAQKKKYQQ 753
Cdd:PTZ00399 615 HDADGEEISKKERKKLSKEYDKQAKLHEE 643
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
28-646 |
8.26e-144 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 429.91 E-value: 8.26e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 28 LTVYNSLTRQKEVFVPNEGKRVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRdYFGYDVEFIMNITDVDDKIIKRARq 107
Cdd:COG0215 2 LKLYNTLTRKKEEFVPLEPGKVRMYVCGPTVYDYAHIGHARTFVVFDVLRRYLR-YLGYKVTYVRNITDVDDKIIKRAA- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 108 shllksyfnesqappvmkvcedvvaalehfktkfetemdpdkkkmfevmikkvqqqssaleeamkaqdsiatEEakgrll 187
Cdd:COG0215 80 ------------------------------------------------------------------------EE------ 81
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 188 nesrdvlsewldhnhGKDVRDhsvfddLAKTYEKEFLADMARLNVLPVDVLTRVSEYVPEVITYVKKIISNGYAYAAeDG 267
Cdd:COG0215 82 ---------------GESIWE------LAERYIAAFHEDMDALGVLPPDIEPRATEHIPEMIELIERLIEKGHAYEA-DG 139
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 268 SVYFDTKAFEqnpkhfyaklvpeAYGEDSEQLLKNMkESEGELSMSDDrlksKRSPNDFALWKSSKDGEPFWPSEWGNGR 347
Cdd:COG0215 140 DVYFDVRSFP-------------DYGKLSGRNLDDL-RAGARVEVDEE----KRDPLDFALWKAAKPGEPSWDSPWGRGR 201
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 348 PGWHIECSVMSSAICGSKLDIHAGGFDLKFPHHDNEIAQVEAHYDDPhWVNYFLHCGTLRIQGMKMSKSLKNFITIRKAL 427
Cdd:COG0215 202 PGWHIECSAMSTKYLGETFDIHGGGIDLIFPHHENEIAQSEAATGKP-FARYWMHNGFLTVNGEKMSKSLGNFFTVRDLL 280
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 428 EDYTPRQLRLLFLMHNWADVLDYSSSTMERALQ-FEKITNeffllvkdFLRRHykpdrsegyQKFQGKELKLMEEFGKLK 506
Cdd:COG0215 281 KKYDPEVLRFFLLSAHYRSPLDFSEEALEEAEKaLERLYN--------ALRRL---------EEALGAADSSAEEIEELR 343
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 507 SEVHEALCDSVDTRSVIEKFRELISLGNAYIVEKEKEghvpncLLLRNIAAYITNLLKIFGAIPQSNQEIGFVSEDEcng 586
Cdd:COG0215 344 EEFIAAMDDDFNTPEALAVLFELVREINKALDEGEDK------AALAALAALLRALGGVLGLLLLEPEAWQGAAEDE--- 414
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 587 egastsfnkeavvmpYLDALAQFREKVRLIAKEHKvNgiLEECDTLRDKtLTELGVRLED 646
Cdd:COG0215 415 ---------------LLDALIEALIEERAEARKAK-D--FARADRIRDE-LAALGIVLED 455
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
41-458 |
5.04e-124 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 372.86 E-value: 5.04e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 41 FVPNEGKRVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRdYFGYDVEFIMNITDVDDKIIKRARQshllksyfnesqa 120
Cdd:pfam01406 2 FVPLHQGKVTMYVCGPTVYDYSHIGHARSAVAFDVLRRYLQ-ALGYDVQFVQNFTDIDDKIIKRARQ------------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 121 ppvmkvcedvvaalehfktkfetemdpdkkkmfevmikkvqqqssaleeamkaqdsiateeakgrlLNESrdvlsewldh 200
Cdd:pfam01406 68 ------------------------------------------------------------------EGES---------- 71
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 201 nhgkdvrdhsvFDDLAKTYEKEFLADMARLNVLPVDVLTRVSEYVPEVITYVKKIISNGYAYAAEDGSVYFDTKAFeqnp 280
Cdd:pfam01406 72 -----------FRQLAARFIEAYTKDMDALNVLPPDLEPRVTEHIDEIIEFIERLIKKGYAYVSDNGDVYFDVSSF---- 136
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 281 kHFYAKLVPEaygeDSEQLlknmkesegELSMSDDRLKSKRSPNDFALWKSSKDGEPFWPSEWGNGRPGWHIECSVMSSA 360
Cdd:pfam01406 137 -PDYGKLSGQ----NLEQL---------EAGARGEVSEGKRDPLDFALWKASKEGEPSWDSPWGKGRPGWHIECSAMARK 202
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 361 ICGSKLDIHAGGFDLKFPHHDNEIAQVEAHYDDPhWVNYFLHCGTLRIQGMKMSKSLKNFITIRKALEDYTPRQLRLLFL 440
Cdd:pfam01406 203 YLGDQIDIHGGGIDLAFPHHENEIAQSEAAFDKQ-LANYWLHNGHVMIDGEKMSKSLGNFFTIRDVLKRYDPEILRYFLL 281
|
410
....*....|....*...
gi 2220285674 441 MHNWADVLDYSSSTMERA 458
Cdd:pfam01406 282 SVHYRSPLDFSEELLEQA 299
|
|
| cysS |
TIGR00435 |
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not ... |
28-654 |
1.66e-122 |
|
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not from all species. The enzyme from one archaeal species, Archaeoglobus fulgidus, is found but the equivalent enzymes from some other Archaea, including Methanococcus jannaschii, are not found, although biochemical evidence suggests that tRNA(Cys) in these species are charged directly with Cys rather than through a misacylation and correction pathway as for tRNA(Gln). [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273076 [Multi-domain] Cd Length: 464 Bit Score: 374.80 E-value: 1.66e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 28 LTVYNSLTRQKEVFVPNEGKRVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRdYFGYDVEFIMNITDVDDKIIKRARQ 107
Cdd:TIGR00435 1 LKLYNTLTRQKEEFEPLVQGKVKMYVCGPTVYDYCHIGHARTAIVFDVLRRYLR-YLGYKVQYVQNITDIDDKIIKRARE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 108 shllksyfnesqappvmkvcedvvaalehfktkfetemdpdkkkmfevmikkvqqqssaleeamkaqdsiateeakgrlL 187
Cdd:TIGR00435 80 -------------------------------------------------------------------------------N 80
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 188 NESRDVLSEwldhnhgkdvrdhsvfddlakTYEKEFLADMARLNVLPVDVLTRVSEYVPEVITYVKKIISNGYAYAAEDG 267
Cdd:TIGR00435 81 GESVYEVSE---------------------RFIEAYFEDMKALNVLPPDLEPRATEHIDEIIEFIEQLIEKGYAYVSDNG 139
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 268 SVYFDTKAFEQnpkhfyaklvpeaYGEDSEQLLKNMKESEGelsmsDDRLKSKRSPNDFALWKSSKDGEPFWPSEWGNGR 347
Cdd:TIGR00435 140 DVYFDVSKFKD-------------YGKLSKQDLDQLEAGAR-----VDVDEAKRNKLDFVLWKSSKEGEPKWDSPWGKGR 201
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 348 PGWHIECSVMSSAICGSKLDIHAGGFDLKFPHHDNEIAQVEAHYDDPhWVNYFLHCGTLRIQGMKMSKSLKNFITIRKAL 427
Cdd:TIGR00435 202 PGWHIECSAMNDKYLGDQIDIHGGGVDLIFPHHENEIAQSEAAFGKQ-LAKYWMHNGFLMIDNEKMSKSLGNFFTVRDVL 280
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 428 EDYTPRQLRLLFLMHNWADVLDYSSSTMERAlqfeKITNEFFLLVKDFLRRHYKPDRSEGYQKFQgkelkLMEEFgklKS 507
Cdd:TIGR00435 281 KNYDPEILRYFLLSVHYRSPLDFSEELLEAA----KNALERLYKALRVLDTSLAYSGNQSLNKFP-----DEKEF---EA 348
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 508 EVHEALCDSVDTRSVIEKFRELISLGNAYIVEKEKEGHVPNCllLRNIAAYITNLLKIfgaipqsnqEIGFVSEDECNGE 587
Cdd:TIGR00435 349 RFVEAMDDDLNTANALAVLFELAKSINLTFVSKADAALLIEH--LIFLESRLGLLLGL---------PSKPVQAGSNDDL 417
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2220285674 588 GAStsfnkEAVVMPyldalaqfrekvRLIAKEHKVngiLEECDTLRDKtLTELGVRLEDRNGQTVVK 654
Cdd:TIGR00435 418 GEI-----EALIEE------------RSIARKEKD---FAKADEIRDE-LAKKGIVLEDTPQGTTWR 463
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
29-451 |
1.75e-96 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 297.95 E-value: 1.75e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 29 TVYNSLTRQKEVFVPNEGKRVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRDYfGYDVEFIMNITDVDDKIIKRARQS 108
Cdd:cd00672 1 RLYNTLTRQKEEFVPLNPGLVTMYVCGPTVYDYAHIGHARTYVVFDVLRRYLEDL-GYKVRYVQNITDIDDKIIKRAREE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 109 HLLksyfnesqappvmkvcedvvaalehfktkfetemdpdkkkmfevmikkvqqqssaleeamkaqdsiateeakgrlln 188
Cdd:cd00672 80 GLS----------------------------------------------------------------------------- 82
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 189 esrdvlsewldhnhgkdvrdhsvFDDLAKTYEKEFLADMARLNVLPVDVLTRVseyvpevityvkkiisngyayaaedgs 268
Cdd:cd00672 83 -----------------------WKEVADYYTKEFFEDMKALNVLPPDVVPRV--------------------------- 112
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 269 vyfdtkafeqnpkhfyaklvpeaygedseqllknmkesegelsmsddrlkskrspndfalwksskdgepfwpsewgngrp 348
Cdd:cd00672 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 349 gWHIECSVMSSAICGSKLDIHAGGFDLKFPHHDNEIAQVEAHYDDPhWVNYFLHCGTLRIQGMKMSKSLKNFITIRKALE 428
Cdd:cd00672 113 -WHIECSAMAMKYLGETFDIHGGGVDLIFPHHENEIAQSEAATGKP-FARYWLHTGHLTIDGEKMSKSLGNFITVRDALK 190
|
410 420
....*....|....*....|...
gi 2220285674 429 DYTPRQLRLLFLMHNWADVLDYS 451
Cdd:cd00672 191 KYDPEVLRLALLSSHYRSPLDFS 213
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00399 |
PTZ00399 |
cysteinyl-tRNA-synthetase; Provisional |
15-753 |
0e+00 |
|
cysteinyl-tRNA-synthetase; Provisional
Pssm-ID: 240402 [Multi-domain] Cd Length: 651 Bit Score: 755.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 15 HWDQP-KNATPPPQLTVYNSLTRQKEVFVPNEGKRVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRDYFGYDVEFIMN 93
Cdd:PTZ00399 26 EWKKPsKEGKYLTGLKVNNSLTGGKVEFVPQNGRQVRWYTCGPTVYDSSHLGHARTYVTFDIIRRILEDYFGYDVFYVMN 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 94 ITDVDDKIIKRARQSHLlksyfnesqappvmkvcedvvaalehfktkfetemdpdkkkmfevmikkvqqqssaleeamka 173
Cdd:PTZ00399 106 ITDIDDKIIKRAREEKL--------------------------------------------------------------- 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 174 qdsiateeakgrllnesrdvlsewldhnhgkdvrdhSVFDDLAKTYEKEFLADMARLNVLPVDVLTRVSEYVPEVITYVK 253
Cdd:PTZ00399 123 ------------------------------------SIFLELARKWEKEFFEDMKALNVRPPDVITRVSEYVPEIVDFIQ 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 254 KIISNGYAYAAEdGSVYFDTKAFEQNpKHFYAKLVPEAYGEDSEqllknMKESEGELSMSDdrlKSKRSPNDFALWKSSK 333
Cdd:PTZ00399 167 KIIDNGFAYESN-GSVYFDVEAFRKA-GHVYPKLEPESVADEDR-----IAEGEGALGKVS---GEKRSPNDFALWKASK 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 334 DGEPFWPSEWGNGRPGWHIECSVMSSAICGSKLDIHAGGFDLKFPHHDNEIAQVEAHYDDPHWVNYFLHCGTLRIQGMKM 413
Cdd:PTZ00399 237 PGEPSWDSPWGKGRPGWHIECSAMASNILGDPIDIHSGGIDLKFPHHDNELAQSEAYFDKHQWVNYFLHSGHLHIKGLKM 316
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 414 SKSLKNFITIRKALEDYTPRQLRLLFLMHNWADVLDYSSSTMERALQFEKITNEFFLLVKDFLRRHYKpdrsEGYQKFQG 493
Cdd:PTZ00399 317 SKSLKNFITIRQALSKYTARQIRLLFLLHKWDKPMNYSDESMDEAIEKDKVFFNFFANVKIKLRESEL----TSPQKWTQ 392
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 494 KELKLMEEFGKLKSEVHEALCDSVDTRSVIEKFRELISLGNAYIVEKEKeghvPNCLLLRNIAAYITNLLKIFGAIPQSn 573
Cdd:PTZ00399 393 HDFELNELFEETKSAVHAALLDNFDTPEALQALQKLISATNTYLNSGEQ----PSAPLLRSVAQYVTKILSIFGLVEGS- 467
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 574 qeigfvsedecNGEGASTSFNKEAVVMPYLDALAQFREKVRLIAKEHKVN--------GILEECDTLRDKTLTELGVRLE 645
Cdd:PTZ00399 468 -----------DGLGSQGQNSTSENFKPLLEALLRFRDEVRDAAKAEMKLisldkkkkQLLQLCDKLRDEWLPNLGIRIE 536
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 646 DR-NGQTVVKLVDRATLLREQEQKDTEKKRKDKEKADKEQKAREKADKEAAAKKIKPEELFKQGEhvGKYSKFDERGVPT 724
Cdd:PTZ00399 537 DKpDGPSVWKLDDKEELQREKEEKEALKEQKRLRKLKKQEEKKKKELEKLEKAKIPPAEFFKRQE--DKYSAFDETGLPT 614
|
730 740
....*....|....*....|....*....
gi 2220285674 725 HLADGTEITKSQIKKLEKVYEAQKKKYQQ 753
Cdd:PTZ00399 615 HDADGEEISKKERKKLSKEYDKQAKLHEE 643
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
28-646 |
8.26e-144 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 429.91 E-value: 8.26e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 28 LTVYNSLTRQKEVFVPNEGKRVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRdYFGYDVEFIMNITDVDDKIIKRARq 107
Cdd:COG0215 2 LKLYNTLTRKKEEFVPLEPGKVRMYVCGPTVYDYAHIGHARTFVVFDVLRRYLR-YLGYKVTYVRNITDVDDKIIKRAA- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 108 shllksyfnesqappvmkvcedvvaalehfktkfetemdpdkkkmfevmikkvqqqssaleeamkaqdsiatEEakgrll 187
Cdd:COG0215 80 ------------------------------------------------------------------------EE------ 81
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 188 nesrdvlsewldhnhGKDVRDhsvfddLAKTYEKEFLADMARLNVLPVDVLTRVSEYVPEVITYVKKIISNGYAYAAeDG 267
Cdd:COG0215 82 ---------------GESIWE------LAERYIAAFHEDMDALGVLPPDIEPRATEHIPEMIELIERLIEKGHAYEA-DG 139
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 268 SVYFDTKAFEqnpkhfyaklvpeAYGEDSEQLLKNMkESEGELSMSDDrlksKRSPNDFALWKSSKDGEPFWPSEWGNGR 347
Cdd:COG0215 140 DVYFDVRSFP-------------DYGKLSGRNLDDL-RAGARVEVDEE----KRDPLDFALWKAAKPGEPSWDSPWGRGR 201
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 348 PGWHIECSVMSSAICGSKLDIHAGGFDLKFPHHDNEIAQVEAHYDDPhWVNYFLHCGTLRIQGMKMSKSLKNFITIRKAL 427
Cdd:COG0215 202 PGWHIECSAMSTKYLGETFDIHGGGIDLIFPHHENEIAQSEAATGKP-FARYWMHNGFLTVNGEKMSKSLGNFFTVRDLL 280
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 428 EDYTPRQLRLLFLMHNWADVLDYSSSTMERALQ-FEKITNeffllvkdFLRRHykpdrsegyQKFQGKELKLMEEFGKLK 506
Cdd:COG0215 281 KKYDPEVLRFFLLSAHYRSPLDFSEEALEEAEKaLERLYN--------ALRRL---------EEALGAADSSAEEIEELR 343
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 507 SEVHEALCDSVDTRSVIEKFRELISLGNAYIVEKEKEghvpncLLLRNIAAYITNLLKIFGAIPQSNQEIGFVSEDEcng 586
Cdd:COG0215 344 EEFIAAMDDDFNTPEALAVLFELVREINKALDEGEDK------AALAALAALLRALGGVLGLLLLEPEAWQGAAEDE--- 414
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 587 egastsfnkeavvmpYLDALAQFREKVRLIAKEHKvNgiLEECDTLRDKtLTELGVRLED 646
Cdd:COG0215 415 ---------------LLDALIEALIEERAEARKAK-D--FARADRIRDE-LAALGIVLED 455
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
41-458 |
5.04e-124 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 372.86 E-value: 5.04e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 41 FVPNEGKRVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRdYFGYDVEFIMNITDVDDKIIKRARQshllksyfnesqa 120
Cdd:pfam01406 2 FVPLHQGKVTMYVCGPTVYDYSHIGHARSAVAFDVLRRYLQ-ALGYDVQFVQNFTDIDDKIIKRARQ------------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 121 ppvmkvcedvvaalehfktkfetemdpdkkkmfevmikkvqqqssaleeamkaqdsiateeakgrlLNESrdvlsewldh 200
Cdd:pfam01406 68 ------------------------------------------------------------------EGES---------- 71
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 201 nhgkdvrdhsvFDDLAKTYEKEFLADMARLNVLPVDVLTRVSEYVPEVITYVKKIISNGYAYAAEDGSVYFDTKAFeqnp 280
Cdd:pfam01406 72 -----------FRQLAARFIEAYTKDMDALNVLPPDLEPRVTEHIDEIIEFIERLIKKGYAYVSDNGDVYFDVSSF---- 136
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 281 kHFYAKLVPEaygeDSEQLlknmkesegELSMSDDRLKSKRSPNDFALWKSSKDGEPFWPSEWGNGRPGWHIECSVMSSA 360
Cdd:pfam01406 137 -PDYGKLSGQ----NLEQL---------EAGARGEVSEGKRDPLDFALWKASKEGEPSWDSPWGKGRPGWHIECSAMARK 202
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 361 ICGSKLDIHAGGFDLKFPHHDNEIAQVEAHYDDPhWVNYFLHCGTLRIQGMKMSKSLKNFITIRKALEDYTPRQLRLLFL 440
Cdd:pfam01406 203 YLGDQIDIHGGGIDLAFPHHENEIAQSEAAFDKQ-LANYWLHNGHVMIDGEKMSKSLGNFFTIRDVLKRYDPEILRYFLL 281
|
410
....*....|....*...
gi 2220285674 441 MHNWADVLDYSSSTMERA 458
Cdd:pfam01406 282 SVHYRSPLDFSEELLEQA 299
|
|
| cysS |
TIGR00435 |
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not ... |
28-654 |
1.66e-122 |
|
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not from all species. The enzyme from one archaeal species, Archaeoglobus fulgidus, is found but the equivalent enzymes from some other Archaea, including Methanococcus jannaschii, are not found, although biochemical evidence suggests that tRNA(Cys) in these species are charged directly with Cys rather than through a misacylation and correction pathway as for tRNA(Gln). [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273076 [Multi-domain] Cd Length: 464 Bit Score: 374.80 E-value: 1.66e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 28 LTVYNSLTRQKEVFVPNEGKRVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRdYFGYDVEFIMNITDVDDKIIKRARQ 107
Cdd:TIGR00435 1 LKLYNTLTRQKEEFEPLVQGKVKMYVCGPTVYDYCHIGHARTAIVFDVLRRYLR-YLGYKVQYVQNITDIDDKIIKRARE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 108 shllksyfnesqappvmkvcedvvaalehfktkfetemdpdkkkmfevmikkvqqqssaleeamkaqdsiateeakgrlL 187
Cdd:TIGR00435 80 -------------------------------------------------------------------------------N 80
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 188 NESRDVLSEwldhnhgkdvrdhsvfddlakTYEKEFLADMARLNVLPVDVLTRVSEYVPEVITYVKKIISNGYAYAAEDG 267
Cdd:TIGR00435 81 GESVYEVSE---------------------RFIEAYFEDMKALNVLPPDLEPRATEHIDEIIEFIEQLIEKGYAYVSDNG 139
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 268 SVYFDTKAFEQnpkhfyaklvpeaYGEDSEQLLKNMKESEGelsmsDDRLKSKRSPNDFALWKSSKDGEPFWPSEWGNGR 347
Cdd:TIGR00435 140 DVYFDVSKFKD-------------YGKLSKQDLDQLEAGAR-----VDVDEAKRNKLDFVLWKSSKEGEPKWDSPWGKGR 201
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 348 PGWHIECSVMSSAICGSKLDIHAGGFDLKFPHHDNEIAQVEAHYDDPhWVNYFLHCGTLRIQGMKMSKSLKNFITIRKAL 427
Cdd:TIGR00435 202 PGWHIECSAMNDKYLGDQIDIHGGGVDLIFPHHENEIAQSEAAFGKQ-LAKYWMHNGFLMIDNEKMSKSLGNFFTVRDVL 280
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 428 EDYTPRQLRLLFLMHNWADVLDYSSSTMERAlqfeKITNEFFLLVKDFLRRHYKPDRSEGYQKFQgkelkLMEEFgklKS 507
Cdd:TIGR00435 281 KNYDPEILRYFLLSVHYRSPLDFSEELLEAA----KNALERLYKALRVLDTSLAYSGNQSLNKFP-----DEKEF---EA 348
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 508 EVHEALCDSVDTRSVIEKFRELISLGNAYIVEKEKEGHVPNCllLRNIAAYITNLLKIfgaipqsnqEIGFVSEDECNGE 587
Cdd:TIGR00435 349 RFVEAMDDDLNTANALAVLFELAKSINLTFVSKADAALLIEH--LIFLESRLGLLLGL---------PSKPVQAGSNDDL 417
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2220285674 588 GAStsfnkEAVVMPyldalaqfrekvRLIAKEHKVngiLEECDTLRDKtLTELGVRLEDRNGQTVVK 654
Cdd:TIGR00435 418 GEI-----EALIEE------------RSIARKEKD---FAKADEIRDE-LAKKGIVLEDTPQGTTWR 463
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
29-451 |
1.75e-96 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 297.95 E-value: 1.75e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 29 TVYNSLTRQKEVFVPNEGKRVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRDYfGYDVEFIMNITDVDDKIIKRARQS 108
Cdd:cd00672 1 RLYNTLTRQKEEFVPLNPGLVTMYVCGPTVYDYAHIGHARTYVVFDVLRRYLEDL-GYKVRYVQNITDIDDKIIKRAREE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 109 HLLksyfnesqappvmkvcedvvaalehfktkfetemdpdkkkmfevmikkvqqqssaleeamkaqdsiateeakgrlln 188
Cdd:cd00672 80 GLS----------------------------------------------------------------------------- 82
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 189 esrdvlsewldhnhgkdvrdhsvFDDLAKTYEKEFLADMARLNVLPVDVLTRVseyvpevityvkkiisngyayaaedgs 268
Cdd:cd00672 83 -----------------------WKEVADYYTKEFFEDMKALNVLPPDVVPRV--------------------------- 112
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 269 vyfdtkafeqnpkhfyaklvpeaygedseqllknmkesegelsmsddrlkskrspndfalwksskdgepfwpsewgngrp 348
Cdd:cd00672 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 349 gWHIECSVMSSAICGSKLDIHAGGFDLKFPHHDNEIAQVEAHYDDPhWVNYFLHCGTLRIQGMKMSKSLKNFITIRKALE 428
Cdd:cd00672 113 -WHIECSAMAMKYLGETFDIHGGGVDLIFPHHENEIAQSEAATGKP-FARYWLHTGHLTIDGEKMSKSLGNFITVRDALK 190
|
410 420
....*....|....*....|...
gi 2220285674 429 DYTPRQLRLLFLMHNWADVLDYS 451
Cdd:cd00672 191 KYDPEVLRLALLSSHYRSPLDFS 213
|
|
| PLN02946 |
PLN02946 |
cysteine-tRNA ligase |
22-458 |
2.56e-87 |
|
cysteine-tRNA ligase
Pssm-ID: 178532 [Multi-domain] Cd Length: 557 Bit Score: 286.06 E-value: 2.56e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 22 ATPPPQLTVYNSLTRQKEVFVPNEGKRVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRdYFGYDVEFIMNITDVDDKI 101
Cdd:PLN02946 54 ASRGRELHLYNTMSRKKELFKPKVEGKVGMYVCGVTAYDLSHIGHARVYVTFDVLYRYLK-HLGYEVRYVRNFTDVDDKI 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 102 IKRARQshllksyfnesqappvmkvcedvvaalehfktkfetemdpdkkkmfevmikkvqqqssaLEEamkaqDSIAtee 181
Cdd:PLN02946 133 IARANE-----------------------------------------------------------LGE-----DPIS--- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 182 akgrllnesrdvlsewldhnhgkdvrdhsvfddLAKTYEKEFLADMARLNVLPVDVLTRVSEYVPEVITYVKKIISNGYA 261
Cdd:PLN02946 146 ---------------------------------LSRRYCEEFLSDMAYLHCLPPSVEPRVSDHIPQIIDMIKQILDNGCA 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 262 YAAeDGSVYFDTKAFeqnpkhfyaklvPEaYGEDSEQLLKNMKEseGELSMSDDRlksKRSPNDFALWKSSKDGEPFWPS 341
Cdd:PLN02946 193 YRV-DGDVYFSVDKF------------PE-YGKLSGRKLEDNRA--GERVAVDSR---KKNPADFALWKAAKEGEPFWDS 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 342 EWGNGRPGWHIECSVMSSAICGSKLDIHAGGFDLKFPHHDNEIAQVEAHYDDPHwVNYFLHCGTLRIQGMKMSKSLKNFI 421
Cdd:PLN02946 254 PWGPGRPGWHIECSAMSAAYLGHSFDIHGGGMDLVFPHHENEIAQSCAACCDSN-ISYWIHNGFVTVDSEKMSKSLGNFF 332
|
410 420 430
....*....|....*....|....*....|....*..
gi 2220285674 422 TIRKALEDYTPRQLRLLFLMHNWADVLDYSSSTMERA 458
Cdd:PLN02946 333 TIRQVIDLYHPLALRLFLLGTHYRSPINYSDVQLESA 369
|
|
| cysS |
PRK14535 |
cysteinyl-tRNA synthetase; Provisional |
26-458 |
5.37e-63 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 173001 [Multi-domain] Cd Length: 699 Bit Score: 223.83 E-value: 5.37e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 26 PQLTVYNSLTRQKEVFVPNEGKRVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRDyFGYDVEFIMNITDVDDKIIKRA 105
Cdd:PRK14535 226 PMTTIYNTLTRQKEPFAPIDPENVRMYVCGMTVYDYCHLGHARVMVVFDMIARWLRE-CGYPLTYVRNITDIDDKIIARA 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 106 RQSHllksyfnesqappvmkvcedvvaalehfktkfetemdpdkkkmfevmikkvqqqssaleeamkaqdsiateEAKGR 185
Cdd:PRK14535 305 AENG-----------------------------------------------------------------------ETIGE 313
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 186 LLNESRDVLSEwldhnhgkdvrdhsvfddlaktyekeflaDMARLNVLPVDVLTRVSEYVPEVITYVKKIISNGYAYAAE 265
Cdd:PRK14535 314 LTARFIQAMHE-----------------------------DADALGVLRPDIEPKATENIPQMIAMIETLIQNGKAYPAA 364
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 266 DGSVYFDTKAFEqnpkhfyaklvpeAYGEDSEQLLKNMKEseGELSMSDDrlkSKRSPNDFALWKSSKDGEPFWPSEWGN 345
Cdd:PRK14535 365 NGDVYYAVREFA-------------AYGQLSGKSLDDLRA--GERVEVDG---FKRDPLDFVLWKAAKAGEPAWESPWGN 426
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 346 GRPGWHIECSVMSSAICGSKLDIHAGGFDLKFPHHDNEIAQVEA--------HYDDPH-------WVNYFLHCGTLRIQG 410
Cdd:PRK14535 427 GRPGWHIECSAMSENLFGDTFDIHGGGADLQFPHHENEIAQSVGatghtcghHHAQTHhgqsiasHVKYWLHNGFIRVDG 506
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 2220285674 411 MKMSKSLKNFITIRKALEDYTPRQLRLLFLMHNWADVLDYSSSTMERA 458
Cdd:PRK14535 507 EKMSKSLGNFFTIREVLKQYDPEVVRFFILRAHYRSPLNYSDAHLDDA 554
|
|
| cysS |
PRK14536 |
cysteinyl-tRNA synthetase; Provisional |
28-458 |
6.96e-59 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 184731 [Multi-domain] Cd Length: 490 Bit Score: 207.47 E-value: 6.96e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 28 LTVYNSLTRQKEVFVPNEGKRVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRdYFGYDVEFIMNITDVddkiikrarq 107
Cdd:PRK14536 3 LRLYNTLGRQQEEFQPIEHGHVRLYGCGPTVYNYAHIGNLRTYVFQDTLRRTLH-FLGYRVTHVMNITDV---------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 108 SHLlksyfnesqappvmkvcedvvaalehfktkfETEMDPDKKKMfevmikkvqqqssaleeamkaqdsIATEEAKGrll 187
Cdd:PRK14536 72 GHL-------------------------------TDDADSGEDKM------------------------VKSAQEHG--- 93
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 188 nesrdvlsewldhnhgkdvrdHSVFDdLAKTYEKEFLADMARLNVLPVDVLTRVSEYVPEVITYVKKIISNGYAYAAeDG 267
Cdd:PRK14536 94 ---------------------KSVLE-IAAHYTAAFFRDTARLNIERPSIVCNATEHIQDMIALIKRLEARGHTYCA-GG 150
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 268 SVYFDTKAFeqnPKhfyaklvpeaYGEDSEQLLKNMKEseGELSMSDdrlKSKRSPNDFALWKSSKDGEP---FWPSEWG 344
Cdd:PRK14536 151 NVYFDIRTF---PS----------YGSLASAAVEDLQA--GARIEHD---TNKRNPHDFVLWFTRSKFENhalTWDSPWG 212
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 345 NGRPGWHIECSVMSSAICGSKLDIHAGGFDLKFPHHDNEIAQVEAHYDDPhWVNYFLHCGTLRIQGMKMSKSLKNFITIR 424
Cdd:PRK14536 213 RGYPGWHIECSAMSMKYLGEQCDIHIGGVDHIRVHHTNEIAQCEAATGKP-WVRYWLHHEFLLMNKGKMSKSAGQFLTLS 291
|
410 420 430
....*....|....*....|....*....|....*
gi 2220285674 425 KALED-YTPRQLRLLFLMHNWADVLDYSSSTMERA 458
Cdd:PRK14536 292 SLQEKgFQPLDYRFFLLGGHYRSQLAFSWEALKTA 326
|
|
| mycothiol_MshC |
TIGR03447 |
cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Members of this ... |
25-460 |
1.24e-56 |
|
cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Members of this protein family are MshC, l-cysteine:1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, an enzyme that uses ATP to ligate a Cys residue to a mycothiol precursor molecule, in the second to last step in mycothiol biosynthesis. This enzyme shows considerable homology to Cys--tRNA ligases, and many instances are misannotated as such. Mycothiol is found in Mycobacterium tuberculosis, Corynebacterium glutamicum, Streptomyces coelicolor, and various other members of the Actinobacteria. Mycothiol is an analog to glutathione. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]
Pssm-ID: 132488 [Multi-domain] Cd Length: 411 Bit Score: 199.18 E-value: 1.24e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 25 PPQLTVYNSLTRQ-KEVFVPNEgkrVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRDYfGYDVEFIMNITDVDDKIIK 103
Cdd:TIGR03447 15 GPPLRLFDTADGQvRPVEPGPE---AGMYVCGITPYDATHLGHAATYLTFDLVNRVWRDA-GHRVHYVQNVTDVDDPLFE 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 104 RArqshllksyfnesqappvmkvcedvvaalehfktkfetemdpdkkkmfevmikkvqqqssaleeamkaqdsiateeak 183
Cdd:TIGR03447 91 RA------------------------------------------------------------------------------ 92
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 184 grllneSRDvlsewldhnhGKDVRDhsvfddLAKTYEKEFLADMARLNVLPVDVLTRVSEYVPEVITYVKKIISNGYAY- 262
Cdd:TIGR03447 93 ------ERD----------GVDWRE------LGTSQIDLFREDMEALRVLPPRDYIGAVESIDEVVEMVEKLLASGAAYi 150
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 263 --AAEDGSVYFDTKAFEQnpkhfyaklvpeaYGEDSEQLLKNMKESEGELSMSDDRlKSKRSPNDFALWKSSKDGEPFWP 340
Cdd:TIGR03447 151 veGPEYPDVYFSIDATEQ-------------FGYESGYDRATMLELFAERGGDPDR-PGKRDPLDALLWRAAREGEPSWD 216
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 341 SEWGNGRPGWHIECSVMSSAICGSKLDIHAGGFDLKFPHHDNEIAQVEAHYDDPHWVNYFLHCGTLRIQGMKMSKSLKNF 420
Cdd:TIGR03447 217 SPFGRGRPGWHIECSAIALNRLGAGFDIQGGGSDLIFPHHEFSAAHAEAATGVRRMARHYVHAGMIGLDGEKMSKSLGNL 296
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 2220285674 421 I---TIRKALEDytPRQLRLLFLMHNWADVLDYSSSTMERALQ 460
Cdd:TIGR03447 297 VfvsKLRAAGVD--PAAIRLGLLAGHYRQDRDWTDAVLAEAEA 337
|
|
| PRK12418 |
PRK12418 |
cysteinyl-tRNA synthetase; Provisional |
44-460 |
6.91e-53 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 183518 [Multi-domain] Cd Length: 384 Bit Score: 187.83 E-value: 6.91e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 44 NEGKRVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRDYfGYDVEFIMNITDVDDKIIKRARqshllksyfnesqappv 123
Cdd:PRK12418 5 APGGTATMYVCGITPYDATHLGHAATYLAFDLVNRVWRDA-GHDVHYVQNVTDVDDPLLERAA----------------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 124 mkvcedvvaalehfktkfetemdpdkkkmfevmikkvqqqssaleeamkaqdsiateeakgrllnesRDvlsewldhnhG 203
Cdd:PRK12418 67 -------------------------------------------------------------------RD----------G 69
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 204 KDVRDhsvfddLAKTYEKEFLADMARLNVLPVDVLTRVSEYVPEVITYVKKIISNGYAY---AAEDGSVYFDTKAfeqnp 280
Cdd:PRK12418 70 VDWRD------LAEREIALFREDMEALRVLPPRDYVGAVESIPEVVELVEKLLASGAAYvvdDEEYPDVYFSVDA----- 138
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 281 khfyaklvPEAYGEDS----EQLLKNMKESEGelsmsDDRLKSKRSPNDFALWKSSKDGEPFWPSEWGNGRPGWHIECSV 356
Cdd:PRK12418 139 --------TPQFGYESgydrATMLELFAERGG-----DPDRPGKRDPLDALLWRAARPGEPSWPSPFGPGRPGWHIECSA 205
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 357 MSSAICGSKLDIHAGGFDLKFPHHDNEIAQVEAHYDDPHWVNYFLHCGTLRIQGMKMSKSLKNFI---TIRKALEDytPR 433
Cdd:PRK12418 206 IALNRLGSGFDIQGGGSDLIFPHHEFSAAHAEAATGERRFARHYVHAGMIGLDGEKMSKSRGNLVfvsRLRAAGVD--PA 283
|
410 420
....*....|....*....|....*..
gi 2220285674 434 QLRLLFLMHNWADVLDYSSSTMERALQ 460
Cdd:PRK12418 284 AIRLALLAGHYRADREWTDAVLAEAEA 310
|
|
| cysS |
PRK14534 |
cysteinyl-tRNA synthetase; Provisional |
28-467 |
1.11e-35 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 173000 [Multi-domain] Cd Length: 481 Bit Score: 141.53 E-value: 1.11e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 28 LTVYNslTRQKEVFVPNEGKRVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRdYFGYDVEFIMNITDV---------- 97
Cdd:PRK14534 3 LKLYN--TKTKDLSELKNFSDVKVYACGPTVYNYAHIGNFRTYIFEDLLIKSLR-LLKYNVNYAMNITDIghltgdfddg 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 98 DDKIIKRARQSHLlksyfnesqappvmKVCEdvvaalehfktkfetemdpdkkkmfevmikkvqqqssaleeamkaqdsi 177
Cdd:PRK14534 80 EDKVVKAARERGL--------------TVYE------------------------------------------------- 96
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 178 ateeakgrllnesrdvlsewldhnhgkdvrdhsvfddLAKTYEKEFLADMARLNVLPVDVLTRVSEYVPEVITYVKKIIS 257
Cdd:PRK14534 97 -------------------------------------ISRFFTEAFFDDCKKLNIVYPDKVLVASEYIPIMIEVVKVLEE 139
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 258 NGYAYAAeDGSVYFDTKAFEqnpkhfyaklvpeAYGEDSEQLLKNMKEsegelsMSDDRL---KSKRSPNDFALWKSS-- 332
Cdd:PRK14534 140 NGFTYFV-NGNVYFDTSCFK-------------SYGQMAGINLNDFKD------MSVSRVeidKSKRNKSDFVLWFTNsk 199
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 333 -KDGEPFWPSEWGNGRPGWHIECSVMSSAICGSKLDIHAGGFDLKFPHHDNEIAQVEAhYDDPHWVNYFLHCGTLRIQGM 411
Cdd:PRK14534 200 fKDQEMKWDSPWGFGYPSWHLECAAMNLEYFKSTLDIHLGGVDHIGVHHINEIAIAEC-YLNKKWCDMFVHGEFLIMEYE 278
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 2220285674 412 KMSKSLKNFITIrKALED--YTPRQLRLLFLMHNWADVLDYSSSTmeraLQFEKITNE 467
Cdd:PRK14534 279 KMSKSNNNFITI-KDLEDqgFSPLDFRYFCLTAHYRTQLKFTFNN----LKACKIARE 331
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
404-580 |
2.13e-07 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 54.49 E-value: 2.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 404 GTLRIQGMKMSKSLKNFITIRKALEDYTPRQLRlLFLMHN---WADvLDYSSSTMERAL-QFEKITNefflLVKDFLRrh 479
Cdd:PRK12300 569 GFVLLEGKKMSKSKGNVIPLRKAIEEYGADVVR-LYLTSSaelLQD-ADWREKEVESVRrQLERFYE----LAKELIE-- 640
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2220285674 480 YKPDRSEGYQkfqgkELKLMEEFGKLKSEVHEALcDSVDTRS-VIEKFRELISLGNAYIvekeKEGHVPNCLLLRNIAAY 558
Cdd:PRK12300 641 IGGEEELRFI-----DKWLLSRLNRIIKETTEAM-ESFQTRDaVQEAFYELLNDLRWYL----RRVGEANNKVLREVLEI 710
|
170 180
....*....|....*....|....*....
gi 2220285674 559 ITNLLKIFgaIPQSNQEI-------GFVS 580
Cdd:PRK12300 711 WIRLLAPF--TPHLAEELwhklggeGFVS 737
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
52-105 |
1.51e-06 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 48.24 E-value: 1.51e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 2220285674 52 YICGPTVYDSSHMGHARSYLSLDILRRVFRDyFGYDVEFIMNITDVDDKIIKRA 105
Cdd:cd00802 2 TFSGITPNGYLHIGHLRTIVTFDFLAQAYRK-LGYKVRCIALIDDAGGLIGDPA 54
|
|
| |
