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Conserved domains on  [gi|25143973|ref|NP_491465|]
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Rho-GAP domain-containing protein [Caenorhabditis elegans]

Protein Classification

rho GTPase-activating 6 family protein( domain architecture ID 10138145)

rho GTPase-activating 6 family protein (RhoGAP6-like) such as RhoGAP6, also known as ArhGAP6, which is both a GTPase-activating protein (GAP) with specificity for RhoA and a cytoskeletal protein that promotes actin remodelling, and RhoGAP36 (ArhGAP36) which is a potent antagonist of PKA signaling

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 520-724 2.87e-105

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239841  Cd Length: 206  Bit Score: 325.93  E-value: 2.87e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 520 DVDPHALQVPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEKVGGGAvindnMVENTTSHDVATLLKEYFRDL 599
Cdd:cd04376   1 SLNPIARQVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVV-----LDENHSVHDVAALLKEFFRDM 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 600 PQSLLPGEHYSAYIGAAKLNVDERIEAIRLLFALLVSPILDTLFVLLKFLHEVSCHSQDRHDEDGELLSGNKMDARNLAT 679
Cdd:cd04376  76 PDPLLPRELYTAFIGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSIDEDGQEVSGNKMTSLNLAT 155

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 25143973 680 IFAPSILRVDHDKL------HETLAENEHQVIIVETMISNVEEIFKIPKEL 724
Cdd:cd04376 156 IFGPNLLHKQKSGErefvqaSLRIEESTAIINVVQTMIDNYEELFMVSPEL 206
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 520-724 2.87e-105

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 325.93  E-value: 2.87e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 520 DVDPHALQVPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEKVGGGAvindnMVENTTSHDVATLLKEYFRDL 599
Cdd:cd04376   1 SLNPIARQVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVV-----LDENHSVHDVAALLKEFFRDM 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 600 PQSLLPGEHYSAYIGAAKLNVDERIEAIRLLFALLVSPILDTLFVLLKFLHEVSCHSQDRHDEDGELLSGNKMDARNLAT 679
Cdd:cd04376  76 PDPLLPRELYTAFIGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSIDEDGQEVSGNKMTSLNLAT 155

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 25143973 680 IFAPSILRVDHDKL------HETLAENEHQVIIVETMISNVEEIFKIPKEL 724
Cdd:cd04376 156 IFGPNLLHKQKSGErefvqaSLRIEESTAIINVVQTMIDNYEELFMVSPEL 206
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 527-714 2.92e-53

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 183.62  E-value: 2.92e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973    527 QVPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEKvgggAVINDNMVENTTSHDVATLLKEYFRDLPQSLLPG 606
Cdd:smart00324   2 PIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDS----GPDPDLDLSEYDVHDVAGLLKLFLRELPEPLITY 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973    607 EHYSAYIGAAKL-NVDERIEAIRLLFALLVSPILDTLFVLLKFLHEVSCHSqdrhdedgellSGNKMDARNLATIFAPSI 685
Cdd:smart00324  78 ELYEEFIEAAKLeDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHS-----------EENKMTARNLAIVFGPTL 146

                          170       180
                   ....*....|....*....|....*....
gi 25143973    686 LRvDHDKLHETLAENEHQVIIVETMISNV 714
Cdd:smart00324 147 LR-PPDGEVASLKDIRHQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 529-690 2.11e-48

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 168.49  E-value: 2.11e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973   529 PKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEKvgGGAVINDNMVENTtsHDVATLLKEYFRDLPQSLLPGEH 608
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDR--GPDVDLDLEEEDV--HVVASLLKLFLRELPEPLLTFEL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973   609 YSAYIGAAKL-NVDERIEAIRLLFALLVSPILDTLFVLLKFLHEVSCHSQDrhdedgellsgNKMDARNLATIFAPSILR 687
Cdd:pfam00620  77 YEEFIEAAKLpDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDV-----------NKMNAHNLAIVFGPTLLR 145


                  ...
gi 25143973   688 VDH 690
Cdd:pfam00620 146 PPD 148
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 520-724 2.87e-105

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 325.93  E-value: 2.87e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 520 DVDPHALQVPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEKVGGGAvindnMVENTTSHDVATLLKEYFRDL 599
Cdd:cd04376   1 SLNPIARQVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVV-----LDENHSVHDVAALLKEFFRDM 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 600 PQSLLPGEHYSAYIGAAKLNVDERIEAIRLLFALLVSPILDTLFVLLKFLHEVSCHSQDRHDEDGELLSGNKMDARNLAT 679
Cdd:cd04376  76 PDPLLPRELYTAFIGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSIDEDGQEVSGNKMTSLNLAT 155

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 25143973 680 IFAPSILRVDHDKL------HETLAENEHQVIIVETMISNVEEIFKIPKEL 724
Cdd:cd04376 156 IFGPNLLHKQKSGErefvqaSLRIEESTAIINVVQTMIDNYEELFMVSPEL 206
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 527-714 2.92e-53

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 183.62  E-value: 2.92e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973    527 QVPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEKvgggAVINDNMVENTTSHDVATLLKEYFRDLPQSLLPG 606
Cdd:smart00324   2 PIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDS----GPDPDLDLSEYDVHDVAGLLKLFLRELPEPLITY 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973    607 EHYSAYIGAAKL-NVDERIEAIRLLFALLVSPILDTLFVLLKFLHEVSCHSqdrhdedgellSGNKMDARNLATIFAPSI 685
Cdd:smart00324  78 ELYEEFIEAAKLeDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHS-----------EENKMTARNLAIVFGPTL 146

                          170       180
                   ....*....|....*....|....*....
gi 25143973    686 LRvDHDKLHETLAENEHQVIIVETMISNV 714
Cdd:smart00324 147 LR-PPDGEVASLKDIRHQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 529-690 2.11e-48

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 168.49  E-value: 2.11e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973   529 PKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEKvgGGAVINDNMVENTtsHDVATLLKEYFRDLPQSLLPGEH 608
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDR--GPDVDLDLEEEDV--HVVASLLKLFLRELPEPLLTFEL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973   609 YSAYIGAAKL-NVDERIEAIRLLFALLVSPILDTLFVLLKFLHEVSCHSQDrhdedgellsgNKMDARNLATIFAPSILR 687
Cdd:pfam00620  77 YEEFIEAAKLpDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDV-----------NKMNAHNLAIVFGPTLLR 145


                  ...
gi 25143973   688 VDH 690
Cdd:pfam00620 146 PPD 148
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 529-713 7.90e-44

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 156.31  E-value: 7.90e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 529 PKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEKVGggaviNDNMVENTTSHDVATLLKEYFRDLPQSLLPGEH 608
Cdd:cd00159   1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRGE-----DIDDLEDYDVHDVASLLKLYLRELPEPLIPFEL 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 609 YSAYIGAAKL-NVDERIEAIRLLFALLVSPILDTLFVLLKFLHEVSCHSQDrhdedgellsgNKMDARNLATIFAPSILR 687
Cdd:cd00159  76 YDEFIELAKIeDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEV-----------NKMTASNLAIVFAPTLLR 144

                       170       180
                ....*....|....*....|....*.
gi 25143973 688 vDHDKLHETLAENEHQVIIVETMISN 713
Cdd:cd00159 145 -PPDSDDELLEDIKKLNEIVEFLIEN 169
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 528-721 2.70e-29

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 116.03  E-value: 2.70e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 528 VPKIVENCTQYLMTYGLTQvGLFRVAGNTKRCRQLRNALEkvGGGAVIndnmvENTTSHDVATLLKEYFRDLPQSLLPGE 607
Cdd:cd04394  20 VPKFLVDACTFLLDHLSTE-GLFRKSGSVVRQKELKAKLE--GGEACL-----SSALPCDVAGLLKQFFRELPEPLLPYD 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 608 HYSAYIGAAKLNVD-ERIEAIRLLFALLVSPILDTLFVLLKFLHEVSCHSqdrhdedgellSGNKMDARNLATIFAPSIL 686
Cdd:cd04394  92 LHEALLKAQELPTDeERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRC-----------SENKMDSSNLAVIFAPNLF 160

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 25143973 687 RV--DHDKL-HETLAENEHQVIIVETMISNVEEIFKIP 721
Cdd:cd04394 161 QSeeGGEKMsSSTEKRLRLQAAVVQTLIDNASNIGIVP 198
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 510-718 4.54e-29

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 114.92  E-value: 4.54e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 510 FSCSLDANiddVDPHALQVPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEKVGGGAVINDNMVENTTShdVA 589
Cdd:cd04372   1 YGCDLTTL---VKAHNTQRPMVVDMCIREIEARGLQSEGLYRVSGFAEEIEDVKMAFDRDGEKADISATVYPDINV--IT 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 590 TLLKEYFRDLPQSLLPGEHYSAYIGAAKL-NVDERIEAIRLLFALLVSPILDTLFVLLKFLHEVSCHSQDrhdedgells 668
Cdd:cd04372  76 GALKLYFRDLPIPVITYDTYPKFIDAAKIsNPDERLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKD---------- 145

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 25143973 669 gNKMDARNLATIFAPSILRVDHDKLHETLAENEHQVIIVETMISNVEEIF 718
Cdd:cd04372 146 -NKMNAENLGIVFGPTLMRPPEDSALTTLNDMRYQILIVQLLITNEDVLF 194
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 528-718 1.66e-28

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 113.27  E-value: 1.66e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 528 VPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEK-VGGGAVINDNMVENTTsHDVATLLKEYFRDLPQSLLPG 606
Cdd:cd04398  16 VPNIVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKELFDKdPLNVLLISPEDYESDI-HSVASLLKLFFRELPEPLLTK 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 607 EHYSAYIGAAKlNVDERIEAIRL--LFALLVSPILDTLFVLLKFLHEVSCHSqdrhdedgellSGNKMDARNLATIFAPS 684
Cdd:cd04398  95 ALSREFIEAAK-IEDESRRRDALhgLINDLPDANYATLRALMFHLARIKEHE-----------SVNRMSVNNLAIIWGPT 162

                       170       180       190
                ....*....|....*....|....*....|....
gi 25143973 685 ILRVDHDklheTLAENEHQVIIVETMISNVEEIF 718
Cdd:cd04398 163 LMNAAPD----NAADMSFQSRVIETLLDNAYQIF 192
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 528-711 4.96e-28

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 112.11  E-value: 4.96e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 528 VPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEKVGGGAVINDNMVENTtsHDVATLLKEYFRDLPQSLLPGE 607
Cdd:cd04395  18 VPLIVEVCCNIVEARGLETVGIYRVPGNNAAISALQEELNRGGFDIDLQDPRWRDV--NVVSSLLKSFFRKLPEPLFTNE 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 608 HYSAYIGAAKL-NVDERIEAIRLLFALLVSPILDTLFVLLKFLHEVSCHSQDrhdedgellsgNKMDARNLATIFAPSIL 686
Cdd:cd04395  96 LYPDFIEANRIeDPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEV-----------NKMEPRNLAIVFGPTLV 164

                       170       180
                ....*....|....*....|....*
gi 25143973 687 RVDHDKLHETLAENEHQVIIVETMI 711
Cdd:cd04395 165 RTSDDNMETMVTHMPDQCKIVETLI 189
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 521-724 3.48e-27

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 110.15  E-value: 3.48e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 521 VDPHALQVPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEKvgGGAVINDNMVENTTShdVATLLKEYFRDLP 600
Cdd:cd04397  20 VGPGKLRIPALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDK--NPTEVPDLSKENPVQ--LAALLKKFLRELP 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 601 QSLLPGEHYSAYIGAAKL-NVDERIEAIRLLFALLVSPILDTLFVLLKFLHEVSCHSQDrhDEDgellSGNKMDARNLAT 679
Cdd:cd04397  96 DPLLTFKLYRLWISSQKIeDEEERKRVLHLVYCLLPKYHRDTMEVLFSFLKWVSSFSHI--DEE----TGSKMDIHNLAT 169

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 25143973 680 IFAPSILRVDHDKlhETLAENEHQVI-IVETMISNVEEIFKIPKEL 724
Cdd:cd04397 170 VITPNILYSKTDN--PNTGDEYFLAIeAVNYLIENNEEFCEVPDEL 213
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 528-713 1.90e-25

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 104.31  E-value: 1.90e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 528 VPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEK--VGGGAVINDNMVenttsHDVATLLKEYFRDLPQSLLP 605
Cdd:cd04385  15 IPVIVDKCIDFITQHGLMSEGIYRKNGKNSSVKKLLEAFRKdaRSVQLREGEYTV-----HDVADVLKRFLRDLPDPLLT 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 606 GEHYSAYIGAAKL-NVDERIEAIRLLFALLvSPI-LDTLFVLLKFLHEVSCHSQDrhdedgellsgNKMDARNLATIFAP 683
Cdd:cd04385  90 SELHAEWIEAAELeNKDERIARYKELIRRL-PPInRATLKVLIGHLYRVQKHSDE-----------NQMSVHNLALVFGP 157

                       170       180       190
                ....*....|....*....|....*....|
gi 25143973 684 SILRVDHDklheTLAENEHQVIIVETMISN 713
Cdd:cd04385 158 TLFQTDEH----SVGQTSHEVKVIEDLIDN 183
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 526-725 3.50e-25

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 104.74  E-value: 3.50e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 526 LQVPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALE-KVGGGavinDNMVENTTSHDVATLLKEYFRDLPQSLL 604
Cdd:cd04391  20 SKVPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEaKFYEG----TFLWDQVKQHDAASLLKLFIRELPQPLL 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 605 PGEHYSAYIGAAKL-NVDERIEAIRLLFALLVSPILDTLFVLLKFLHEVSCHsQDRhdedgellsgNKMDARNLATIFAP 683
Cdd:cd04391  96 TVEYLPAFYSVQGLpSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDH-EEK----------NKMNLWNVAMIMAP 164

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 25143973 684 SIL--RVDHDKLHETLAEnehQVI-------IVETMISNVEEIFKIPKELQ 725
Cdd:cd04391 165 NLFppRGKHSKDNESLQE---EVNmaagcanIMRLLIRYQDLLWTVPSFLI 212
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 544-724 7.75e-25

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 103.31  E-value: 7.75e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 544 LTQVGLFRVAGNTKRCRQLRNALEKvggGAVINDNMVEnTTSHDVATLLKEYFRDLPQSLLPGEHYSAYIGAAKL----- 618
Cdd:cd04392  24 LRVEGLFRKPGNSARQQELRDLLNS---GTDLDLESGG-FHAHDCATVLKGFLGELPEPLLTHAHYPAHLQIADLcqfde 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 619 --------NVDERIEAIRLLFALLVSPILDTLFVLLKFLHEVSCHsQDRhdedgellsgNKMDARNLATIFAPSIL---R 687
Cdd:cd04392 100 kgnktsapDKERLLEALQLLLLLLPEENRNLLKLILDLLYQTAKH-EDK----------NKMSADNLALLFTPHLIcprN 168

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 25143973 688 VDHDKLHETLaenEHQVIIVETMISNVEEIFKIPKEL 724
Cdd:cd04392 169 LTPEDLHENA---QKLNSIVTFMIKHSQKLFKAPAYL 202
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 528-724 1.28e-23

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 100.18  E-value: 1.28e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 528 VPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEkvgggAVINDNMVENTTSHDVATLLKEYFRDLPQSLLPGE 607
Cdd:cd04375  20 LPRSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIE-----SSTDNVNYDGQQAYDVADMLKQYFRDLPEPLLTNK 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 608 HYSAYIGAAK-LNVDERIEAIRLLFALLVSPILDTLFVLLKFLHEVSCHSQDrhdedgellsgNKMDARNLATIFAPSIL 686
Cdd:cd04375  95 LSETFIAIFQyVPKEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANSQE-----------NQMTATNLAVCLAPSLF 163

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 25143973 687 RVDHDKLHET-------------------LAENEHQVIIVETMISNVEEIFKIPKEL 724
Cdd:cd04375 164 HLNTSRRENSsparrmqrkkslgkpdqkeLSENKAAHQCLAYMIEECNTLFMVPKEM 220
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 528-718 1.50e-23

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 99.30  E-value: 1.50e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 528 VPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRnalEKVGGGAVINdnmVENTTSHDVATLLKEYFRDLPQSLLPGE 607
Cdd:cd04402  15 LPKPILDMLSLLYQKGPSTEGIFRRSANAKACKELK---EKLNSGVEVD---LKAEPVLLLASVLKDFLRNIPGSLLSSD 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 608 HYSAYIGA-AKLNVDERIEAIRLLFALLVSPILDTLFVLLKFLHEVSCHSQDrhdedgellsgNKMDARNLATIFAPSIL 686
Cdd:cd04402  89 LYEEWMSAlDQENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSET-----------NKMDAFNLAVCIAPSLL 157

                       170       180       190
                ....*....|....*....|....*....|..
gi 25143973 687 RVDHDKLHETlAENEHQVIIVETMISNVEEIF 718
Cdd:cd04402 158 WPPASSELQN-EDLKKVTSLVQFLIENCQEIF 188
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 531-718 5.22e-23

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 97.91  E-value: 5.22e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 531 IVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEkvgGGAVINDNMVENTTSHDVATLLKEYFRDLPQSLLPGEHYS 610
Cdd:cd04386  23 PIEACVMCLLETGMNEEGLFRVGGGASKLKRLKAALD---AGTFSLPLDEFYSDPHAVASALKSYLRELPDPLLTYNLYE 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 611 AYIGAAKL-NVDERIEAIRLLFALLVSPILDTLFVLLKFLHEVschsQDRHDEdgellsgNKMDARNLATIFAPSIL--R 687
Cdd:cd04386 100 DWVQAANKpDEDERLQAIWRILNKLPRENRDNLRYLIKFLSKL----AQKSDE-------NKMSPSNIAIVLAPNLLwaK 168

                       170       180       190
                ....*....|....*....|....*....|.
gi 25143973 688 VDHDKLHETLAENEHQVIIVETMISNVEEIF 718
Cdd:cd04386 169 NEGSLAEMAAGTSVHVVAIVELIISHADWFF 199
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 528-713 1.41e-21

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 93.64  E-value: 1.41e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 528 VPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEkvgggavINDNMVE--NTTSHDVATLLKEYFRDLPQSLLP 605
Cdd:cd04378  16 VPFIIKKCTSEIENRALGVQGIYRVSGSKARVEKLCQAFE-------NGKDLVElsELSPHDISSVLKLFLRQLPEPLIL 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 606 GEHYSAYIGAAK--LNVDER-------------IEAIRLLFALLVSPILDTLFVLLKFLHEVSCHSQDrhdedgellsgN 670
Cdd:cd04378  89 FRLYNDFIALAKeiQRDTEEdkapntpievnriIRKLKDLLRQLPASNYNTLQHLIAHLYRVAEQFEE-----------N 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 25143973 671 KMDARNLATIFAPSILR---VDHDKLHETLAENEHQVIIVETMISN 713
Cdd:cd04378 158 KMSPNNLGIVFGPTLIRprpGDADVSLSSLVDYGYQARLVEFLITN 203
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 528-692 9.97e-21

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 90.94  E-value: 9.97e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 528 VPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEKVgggaviNDNMVENTTSHD---VATLLKEYFRDLPQSLL 604
Cdd:cd04383  18 IPLVVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNAFERG------EDPLADDQNDHDinsVAGVLKLYFRGLENPLF 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 605 PGEHYSAYIGAAKL-NVDERIEAIRLLFALLVSPILDTLFVLLKFLHEVSCHSQDrhdedgellsgNKMDARNLATIFAP 683
Cdd:cd04383  92 PKERFEDLMSCVKLeNPTERVHQIREILSTLPRSVIIVMRYLFAFLNHLSQFSDE-----------NMMDPYNLAICFGP 160


                ....*....
gi 25143973 684 SILRVDHDK 692
Cdd:cd04383 161 TLMPVPEGQ 169
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 527-718 1.89e-20

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 90.58  E-value: 1.89e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 527 QVPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEkvGGGAVINDNmveNTTSHDVATLLKEYFRDLPQSLLPG 606
Cdd:cd04390  21 LVPILVEQCVDFIREHGLKEEGLFRLPGQANLVKQLQDAFD--AGERPSFDS---DTDVHTVASLLKLYLRELPEPVIPW 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 607 EHYSAYIGAAK-LNVDERIEAIRLLFALLVSPI--LDTLFVLLKFLHEVSCHSqdrhdedgellSGNKMDARNLATIFAP 683
Cdd:cd04390  96 AQYEDFLSCAQlLSKDEEKGLGELMKQVSILPKvnYNLLSYICRFLDEVQSNS-----------SVNKMSVQNLATVFGP 164

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 25143973 684 SILRVDHDKlHETLAENEHQVIIVET-MISNVEEIF 718
Cdd:cd04390 165 NILRPKVED-PATIMEGTPQIQQLMTvMISKHEPLF 199
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 528-687 1.99e-19

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 87.39  E-value: 1.99e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 528 VPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRnalEKVGGGAVINDNMVENttSHDVATLLKEYFRDLPQSLLPGE 607
Cdd:cd04404  23 IPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQ---QKYNMGEPVDFDQYED--VHLPAVILKTFLRELPEPLLTFD 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 608 HYSAYIGAAKLNVDERIEAIRLLFALLVSPILDTLFVLLKFLHEVSCHSQDrhdedgellsgNKMDARNLATIFAPSILR 687
Cdd:cd04404  98 LYDDIVGFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQ-----------NKMTNSNLAVVFGPNLLW 166
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 528-713 8.41e-19

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 85.21  E-value: 8.41e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 528 VPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEKvgGGAVindNMVENTTSHDVATLLKEYFRDLPQSLLPGE 607
Cdd:cd04393  20 VPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDS--GEEV---DLSKEADVCSAASLLRLFLQELPEGLIPAS 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 608 HYSAYIgaaKLNVDERIEAI---RLLFALLVSPilDTLFVLLK----FLHEVSCHSQDrhdedgellsgNKMDARNLATI 680
Cdd:cd04393  95 LQIRLM---QLYQDYNGEDEfgrKLRDLLQQLP--PVNYSLLKflchFLSNVASQHHE-----------NRMTAENLAAV 158

                       170       180       190
                ....*....|....*....|....*....|...
gi 25143973 681 FAPSILRVDHDKlhETLAENEHQVIIVETMISN 713
Cdd:cd04393 159 FGPDVFHVYTDV--EDMKEQEICSRIMAKLLEN 189
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 528-711 1.20e-18

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 85.63  E-value: 1.20e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 528 VPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEKvgggaviNDNMVE--NTTSHDVATLLKEYFRDLPQSLLP 605
Cdd:cd04409  16 IPFIIKKCTSEIESRALCLKGIYRVNGAKSRVEKLCQAFEN-------GKDLVElsELSPHDISNVLKLYLRQLPEPLIL 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 606 GEHYSAYIGAAK--LNVDER---------------IEAIRLLFAL------LVSPILDTLFVLLKFLHEVSCHSQDrhde 662
Cdd:cd04409  89 FRLYNEFIGLAKesQHVNETqeakknsdkkwpnmcTELNRILLKSkdllrqLPAPNYNTLQFLIVHLHRVSEQAEE---- 164

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 25143973 663 dgellsgNKMDARNLATIFAPSILRVDHDKLH---ETLAENEHQVIIVETMI 711
Cdd:cd04409 165 -------NKMSASNLGIIFGPTLIRPRPTDATvslSSLVDYPHQARLVELLI 209
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 527-713 2.29e-18

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 84.04  E-value: 2.29e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 527 QVPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEKVGggaviNDNMVE-NTTSHDVATLLKEYFRDLPQSLLP 605
Cdd:cd04373  14 PIPIFLEKCVEFIEATGLETEGIYRVSGNKTHLDSLQKQFDQDH-----NLDLVSkDFTVNAVAGALKSFFSELPDPLIP 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 606 GEHYSAYIGAAKLNVDE-RIEAIRLLFALLVSPILDTLFVLLKFLHEVSCHSQDrhdedgellsgNKMDARNLATIFAPS 684
Cdd:cd04373  89 YSMHLELVEAAKINDREqRLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKV-----------NLMTSENLSICFWPT 157

                       170       180
                ....*....|....*....|....*....
gi 25143973 685 ILRVDHDKLHETLAENEHQVIIvETMISN 713
Cdd:cd04373 158 LMRPDFTSMEALSATRIYQTII-ETFIQQ 185
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 528-713 4.56e-18

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 83.21  E-value: 4.56e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 528 VPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLR---NALEKVgggaviNDNMVENTTSHDVATLLKEYFRDLPQSLL 604
Cdd:cd04403  16 VPKFVRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLRfavDHDEKL------DLDDSKWEDIHVITGALKLFFRELPEPLF 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 605 PGEHYSAYIGAAKL-NVDERIEAIRLLFALLVSPILDTLFVLLKFLHEVSCHSqdrhdedgellSGNKMDARNLATIFAP 683
Cdd:cd04403  90 PYSLFNDFVAAIKLsDYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHG-----------EKNRMTTQNLAIVFGP 158

                       170       180       190
                ....*....|....*....|....*....|...
gi 25143973 684 SILRVDHDKLH---ETLAENEhqviIVETMISN 713
Cdd:cd04403 159 TLLRPEQETGNiavHMVYQNQ----IVELILLE 187
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 510-711 1.65e-17

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 81.33  E-value: 1.65e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 510 FSCSLDANIDDVDPhalqVPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEKvgGGAVINdnmVENTTSHDVA 589
Cdd:cd04377   1 FGVSLSSLTSEDRS----VPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDT--DPDSVN---LEDYPIHVIT 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 590 TLLKEYFRDLPQSLLPGEHYSAYIGAAKL-NVDERIEAIRLLFALLVSPILDTLFVLLKFLHEVSCHsqdrhdEDgells 668
Cdd:cd04377  72 SVLKQWLRELPEPLMTFELYENFLRAMELeEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQ------EE----- 140

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 25143973 669 GNKMDARNLATIFAPSILRV-DHDKLHETLAENEHQVIIVETMI 711
Cdd:cd04377 141 VNRMSANALAIVFAPCILRCpDTADPLQSLQDVSKTTTCVETLI 184
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 530-713 3.24e-17

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 81.29  E-value: 3.24e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 530 KIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNAL----EKVGGGAVINDNMVENTTshdVATLLKEYFRDLPQSLLP 605
Cdd:cd04374  30 KFVRKCIEAVETRGINEQGLYRVVGVNSKVQKLLSLGldpkTSTPGDVDLDNSEWEIKT---ITSALKTYLRNLPEPLMT 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 606 GEHYSAYIGAAKL-NVDERIEAIRLLFALLVSPILDTLFVLLKFLHEVSCHSQDrhdedgellsgNKMDARNLATIFAPS 684
Cdd:cd04374 107 YELHNDFINAAKSeNLESRVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKK-----------NLMTVSNLGVVFGPT 175

                       170       180       190
                ....*....|....*....|....*....|..
gi 25143973 685 ILRVDhdklHETLA---ENEHQVIIVETMISN 713
Cdd:cd04374 176 LLRPQ----EETVAaimDIKFQNIVVEILIEN 203
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 528-713 1.56e-16

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 79.76  E-value: 1.56e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 528 VPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEKVGG-GAVINDnmvENTTSHDVATLLKEYFRDLPQSLLPG 606
Cdd:cd04396  32 IPVVVAKCGVYLKENATEVEGIFRVAGSSKRIRELQLIFSTPPDyGKSFDW---DGYTVHDAASVLRRYLNNLPEPLVPL 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 607 E----------------HYSAYIGAAKLN--VDERIEAIRLLFALLVSPILDTLFVLLKFLHEVSCHSQDrhdedgells 668
Cdd:cd04396 109 DlyeefrnplrkrprilQYMKGRINEPLNtdIDQAIKEYRDLITRLPNLNRQLLLYLLDLLAVFARNSDK---------- 178

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 25143973 669 gNKMDARNLATIFAPSILrvDHDKlHEtLAENEHQ--VIIVETMISN 713
Cdd:cd04396 179 -NLMTASNLAAIFQPGIL--SHPD-HE-MDPKEYKlsRLVVEFLIEH 220
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 527-687 5.45e-16

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 77.28  E-value: 5.45e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 527 QVPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEKVGGGAVIndnMVENTTSHDVATLLKEYFRDLPQSLLPG 606
Cdd:cd04387  15 KVPYIVRQCVEEVERRGMEEVGIYRISGVATDIQALKAAFDTNNKDVSV---MLSEMDVNAIAGTLKLYFRELPEPLFTD 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 607 EHYSAYIGAAKLNvDERIEAIRLLFAL--LVSPILDTLFVLLKFLHEVSchsqDRHDEdgellsgNKMDARNLATIFAPS 684
Cdd:cd04387  92 ELYPNFAEGIALS-DPVAKESCMLNLLlsLPDPNLVTFLFLLHHLKRVA----EREEV-------NKMSLHNLATVFGPT 159


                ...
gi 25143973 685 ILR 687
Cdd:cd04387 160 LLR 162
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 528-687 1.82e-14

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 72.92  E-value: 1.82e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 528 VPKIVENCTQYLMTYGLTQvGLFRVAGNTKRCRQLRNALEKVGGGAVINDNMVENTtsHDVATLLKEYFRDLPQSLLPGE 607
Cdd:cd04384  18 VPQVLKSCTEFIEKHGIVD-GIYRLSGIASNIQRLRHEFDSEQIPDLTKDVYIQDI--HSVSSLCKLYFRELPNPLLTYQ 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 608 HYSAYIGA-AKLNVDERIEAIRLLFALLVSPILDTLFVLLKFLHEVSCHSqdrhdedgellSGNKMDARNLATIFAPSIL 686
Cdd:cd04384  95 LYEKFSEAvSAASDEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYC-----------SITNMHAKNLAIVWAPNLL 163


                .
gi 25143973 687 R 687
Cdd:cd04384 164 R 164
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 528-685 2.68e-14

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 72.39  E-value: 2.68e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 528 VPKIVENCTQYLM-TYGLTQVGLFRVAGNTKRCRQLRNALEKVGGGAVINDNMVENTtsHDVATLLKEYFRDLPQSLLPG 606
Cdd:cd04400  22 LPSVVYRCIEYLDkNRAIYEEGIFRLSGSASVIKQLKERFNTEYDVDLFSSSLYPDV--HTVAGLLKLYLRELPTLILGG 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 607 EHYSAYIGAAKLNVD--ERIEAIRLLFALLVSPILDTLFVLLKFLHEVSCHSQDrhdedgellsgNKMDARNLATIFAPS 684
Cdd:cd04400 100 ELHNDFKRLVEENHDrsQRALELKDLVSQLPQANYDLLYVLFSFLRKIIEHSDV-----------NKMNLRNVCIVFSPT 168


                .
gi 25143973 685 I 685
Cdd:cd04400 169 L 169
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 527-713 3.89e-14

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 72.16  E-value: 3.89e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 527 QVPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEkvgggavINDNMVE--NTTSHDVATLLKEYFRDLPQSLL 604
Cdd:cd04408  15 EVPFVVVRCTAEIENRALGVQGIYRISGSKARVEKLCQAFE-------NGRDLVDlsGHSPHDITSVLKHFLKELPEPVL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 605 PGEHYSAYIGAAKL-------------NVDERIEAIRLLFALLVSPILDTLFVLLKFLHEVSCHSQDrhdedgellsgNK 671
Cdd:cd04408  88 PFQLYDDFIALAKElqrdsekaaespsIVENIIRSLKELLGRLPVSNYNTLRHLMAHLYRVAERFED-----------NK 156

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 25143973 672 MDARNLATIFAPSILR--VDHDKLHETLAENEHQVIIVETMISN 713
Cdd:cd04408 157 MSPNNLGIVFGPTLLRplVGGDVSMICLLDTGYQAQLVEFLISN 200
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 510-713 2.34e-13

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 69.34  E-value: 2.34e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 510 FSCSLDANID---DVDPHaLQVPKIVENCTQYLMTYGLTQV-GLFRVAGNTKRCRQLRNALEKvgggAVINDNMVENttS 585
Cdd:cd04389   1 FGSSLEEIMDrqkEKYPE-LKLPWILTFLSEKVLALGGFQTeGIFRVPGDIDEVNELKLRVDQ----WDYPLSGLED--P 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 586 HDVATLLKEYFRDLPQSLLPGEHYSAYIGAAKlNVDERIEAIRLLfallvsPILD--TLFVLLKFLHEVSchsqdrhdeD 663
Cdd:cd04389  74 HVPASLLKLWLRELEEPLIPDALYQQCISASE-DPDKAVEIVQKL------PIINrlVLCYLINFLQVFA---------Q 137

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 25143973 664 GELLSGNKMDARNLATIFAPSILRVDHDKLHETLAENEHQVIIVETMISN 713
Cdd:cd04389 138 PENVAHTKMDVSNLAMVFAPNILRCTSDDPRVIFENTRKEMSFLRTLIEH 187
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 510-687 3.76e-13

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 68.87  E-value: 3.76e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 510 FSCSLDANIDDVDPhalqVPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEkvgggAVINDNMVENTTSHDVA 589
Cdd:cd04407   1 FGVRVGSLTSNKTS----VPIVLEKLLEHVEMHGLYTEGIYRKSGSANRMKELHQLLQ-----ADPENVKLENYPIHAIT 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 590 TLLKEYFRDLPQSLLPGEHYSAYIGAAKL-NVDERIEAIRLLFALLVSPILDTLFVLLKFLHEVSChsqdrhDEDgells 668
Cdd:cd04407  72 GLLKQWLRELPEPLMTFAQYNDFLRAVELpEKQEQLQAIYRVLEQLPTANHNTLERLIFHLVKVAL------EED----- 140

                       170
                ....*....|....*....
gi 25143973 669 GNKMDARNLATIFAPSILR 687
Cdd:cd04407 141 VNRMSPNALAIVFAPCLLR 159
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 518-712 3.32e-12

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 66.16  E-value: 3.32e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 518 IDDVDPHALQVPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEKVGGGAvindnMVENTTSHDVATLLKEYFR 597
Cdd:cd04382   7 ADFDPSTSPMIPALIVHCVNEIEARGLTEEGLYRVSGSEREVKALKEKFLRGKTVP-----NLSKVDIHVICGCLKDFLR 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 598 DLPQSLLPGEHYSAYIGAAK-LNVDERIEAIRLLFALLVSPILDTLFVLLKFLHEVSCHSQdrhdedgellsgNKMDARN 676
Cdd:cd04382  82 SLKEPLITFALWKEFMEAAEiLDEDNSRAALYQAISELPQPNRDTLAFLILHLQRVAQSPE------------CKMDINN 149

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 25143973 677 LATIFAPSIL--RVDHDKLHETLAENEHQVIIVETMIS 712
Cdd:cd04382 150 LARVFGPTIVgySVPNPDPMTILQDTVRQPRVVERLLE 187
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 528-687 3.84e-12

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 66.18  E-value: 3.84e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 528 VPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEkvgggAVINDNMVENTTSHDVATLLKEYFRDLPQSLLPGE 607
Cdd:cd04406  15 VPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLD-----TDANSVNLDDYNIHVIASVFKQWLRDLPNPLMTFE 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 608 HYSAYIGAakLNVDERIEAIRLLFAL---LVSPILDTLFVLLKFLHEVSCHSQDrhdedgellsgNKMDARNLATIFAPS 684
Cdd:cd04406  90 LYEEFLRA--MGLQERRETVRGVYSVidqLSRTHLNTLERLIFHLVRIALQEET-----------NRMSANALAIVFAPC 156


                ...
gi 25143973 685 ILR 687
Cdd:cd04406 157 ILR 159
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 522-686 4.24e-12

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 66.34  E-value: 4.24e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 522 DPHALQVPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEKVGGGAVINDNMVENTTShdVATLLKEYFRDLPQ 601
Cdd:cd04379  12 EGESRDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFERNSAAVELSEELYPDINV--ITGVLKDYLRELPE 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 602 SLLPGEHYSAYIGAAKLNVDERIEAIRLLFALLVSPILD----TLFVLLKFLHEVSCHSQDrhdedgellsgNKMDARNL 677
Cdd:cd04379  90 PLITPQLYEMVLEALAVALPNDVQTNTHLTLSIIDCLPLsakaTLLLLLDHLSLVLSNSER-----------NKMTPQNL 158


                ....*....
gi 25143973 678 ATIFAPSIL 686
Cdd:cd04379 159 AVCFGPVLM 167
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 526-685 4.97e-09

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 56.67  E-value: 4.97e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 526 LQVPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEKVGGGAVindnmvENTTSHDVATLLKEYFRDLPQSLLP 605
Cdd:cd04381  18 IDLPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNRRESPNL------EEYEPPTVASLLKQYLRELPEPLLT 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 606 GEHYSAYIGAA-KLNVDERIEAIRLLFALLvsPILDTLFVLLKFLHEVSCHSQDRHdedgellsgNKMDARNLATIFAPS 684
Cdd:cd04381  92 KELMPRFEEACgRPTEAEREQELQRLLKEL--PECNRLLLAWLIVHMDHVIAQELE---------TKMNIQNISIVLSPT 160


                .
gi 25143973 685 I 685
Cdd:cd04381 161 V 161
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 487-687 7.23e-08

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 54.27  E-value: 7.23e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 487 PTTCEPQQ-VTGRFLKK----QRPASASFSCSLDA-NIDDVDPHALQVPKIVENCTQYLMTYGLTQVGLFRVAGNT---- 556
Cdd:cd04380   3 TVTGVYLPsCFGSSLETlirlPDPGIRNLIDQLELgDNPDYSEVPLSIPKEIWRLVDYLYTRGLAQEGLFEEPGLPsepg 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 557 KRCRQLRNALEKvgggavindNMVENTT--SHDVATLLKEYFRDLPQSLLPGEHYSAYIGAAKLNVDERIEAIRllFALl 634
Cdd:cd04380  83 ELLAEIRDALDT---------GSPFNSPgsAESVAEALLLFLESLPDPIIPYSLYERLLEAVANNEEDKRQVIR--ISL- 150

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 25143973 635 vSPILDTLFV-LLKFLHEVSCHSQDrhdedgellsgNKMDARNLATIFAPSILR 687
Cdd:cd04380 151 -PPVHRNVFVyLCSFLRELLSESAD-----------RGLDENTLATIFGRVLLR 192
RhoGAP_p85 cd04388
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 587-712 1.23e-05

RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) homology (BH) domain. Class IA PI3Ks are heterodimers, containing a regulatory subunit (p85) and a catalytic subunit (p110) and are activated by growth factor receptor tyrosine kinases (RTKs); this activation is mediated by the p85 subunit. p85 isoforms, alpha and beta, contain a C-terminal p110-binding domain flanked by two SH2 domains, an N-terminal SH3 domain, and a RhoGAP domain flanked by two proline-rich regions. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239853  Cd Length: 200  Bit Score: 47.18  E-value: 1.23e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 587 DVATL---LKEYFRDLPQSLLPGEHYSAYIGAAKLNVDERiEAIRLLFALLVSPILD-----TLFVLLKFLHEVSCHSqd 658
Cdd:cd04388  65 DVAALadaLKRYLLDLPNPVIPAPVYSEMISRAQEVQSSD-EYAQLLRKLIRSPNLPhqywlTLQYLLKHFFRLCQSS-- 141

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 25143973 659 rhdedgellSGNKMDARNLATIFAPSILRvdhdklHETLAEN--EHQVIIVETMIS 712
Cdd:cd04388 142 ---------SKNLLSARALAEIFSPLLFR------FQPASSDspEFHIRIIEVLIT 182
RhoGAP_fRGD2 cd04399
RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 561-719 3.52e-05

RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD2-like proteins. Yeast Rgd2 is a GAP protein for Cdc42 and Rho5. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239864  Cd Length: 212  Bit Score: 46.17  E-value: 3.52e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 561 QLRNALEKVGGGAVINDNMVENTTSHdVATLLKEYFRDLPQSLLPGEH-------YSAYIGAAKLNVDERIEAIRLLFAL 633
Cdd:cd04399  55 QLRNLLNKPKKPDKEVIILKKFEPST-VASVLKLYLLELPDSLIPHDIydlirslYSAYPPSQEDSDTARIQGLQSTLSQ 133

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 634 LVSPILDTLFVLLKFLHEVsCHSQDRHDEDGELlsgnkmdARNLATIFAPSILRVDHDKLheTLAENEHQVIIVETMISN 713
Cdd:cd04399 134 LPKSHIATLDAIITHFYRL-IEITKMGESEEEY-------ADKLATSLSREILRPIIESL--LTIGDKHGYKFFRDLLTH 203


                ....*.
gi 25143973 714 VEEIFK 719
Cdd:cd04399 204 KDQIFS 209
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 587-725 2.55e-03

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239870  Cd Length: 235  Bit Score: 40.78  E-value: 2.55e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143973 587 DVATLLKEYFRDLPQSLLPGEHYSAYIGAAKLNVDER----IEAIRLLFALLVSPILDTLFVLLKFLHEVSCHSQDR-HD 661
Cdd:cd04405 107 LLFKTIAKYYGQLKEPLLTFHLFDIFVGILELLGNGKeevaLEALQLCLLLLPPASRRELRRLLRFMARAAKNDMPRlHK 186

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 25143973 662 EdgellSGNKMdarNLATIFAPSILRvdHDKLHETLAENehqviIVETMISNVEEIFKIPKELQ 725
Cdd:cd04405 187 E-----IENRM---LVKQTFSRAILC--SKDLDEGLADL-----LVLFLMDHHQDIFKVPGSLH 235
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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