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Conserved domains on  [gi|17508019|ref|NP_491957|]
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Dipeptidyl Peptidase Four (IV) family [Caenorhabditis elegans]

Protein Classification

S9 family peptidase( domain architecture ID 13559808)

peptidase S9 family protein, an oligopeptidase which may cleave the prolyl bond of short peptides, similar to Apis mellifera venom dipeptidyl peptidase 4 that removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline

CATH:  3.40.50.1820|2.140.10.30
EC:  3.4.-.-
Gene Ontology:  GO:0008236|GO:0006508
MEROPS:  S9
PubMed:  19508187|12369917|35631755
SCOP:  3000102

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
706-914 1.94e-68

Prolyl oligopeptidase family;


:

Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 226.73  E-value: 1.94e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019   706 NDFSWIQYIrFCRLGYVVVFIDNRGSAHRGIEFERHIHKKMGTVEVEDQVEGLQMLAERtgGFMDMSRVVVHGWSYGGYM 785
Cdd:pfam00326   1 PSFSWNAQL-LADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQ--GYTDPDRLAIWGGSYGGYL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019   786 ALQMIAKHPNIYRAAIAGGAVSDWRLYDT----AYTERYMGYP---LEEHVY-GASSITGLVEKLpdEPNRLMLVHGLMD 857
Cdd:pfam00326  78 TGAALNQRPDLFKAAVAHVPVVDWLAYMSdtslPFTERYMEWGnpwDNEEGYdYLSPYSPADNVK--VYPPLLLIHGLLD 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 17508019   858 ENVHFAHLTHLVDECIKKGKWHELVIFPNERHGVRNNDASIYLDARMMYFAQQAIQG 914
Cdd:pfam00326 156 DRVPPWQSLKLVAALQRKGVPFLLLIFPDEGHGIGKPRNKVEEYARELAFLLEYLGG 212
DPPIV_N super family cl37636
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 245-574 1.52e-26

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


The actual alignment was detected with superfamily member pfam00930:

Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 112.03  E-value: 1.52e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019   245 PPTNNFVSSAKVCPaDSSLLAYVLNKQVYIEK--NGKIIHRTSSNSKHITNGVPSYIVQEE-LERFEGIWWSESKTRLLY 321
Cdd:pfam00930  39 PPGEGKIQDAKWSP-DGDRLAFVRDNNLYVRElaTGKEIQITSDGSDGIFNGVADWVYEEEvLGSNSAVWWSPDGSRLAF 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019   322 EHVNEEKVAESQFGVNGDPPVAP----MKYPRAGTKNAYSTLRMVILENGKAYDVPLKDEVIYKHcpfyEYITRAGFFSD 397
Cdd:pfam00930 118 LRFDESEVPIITLPYYTDEGPGPevreIKYPKAGAPNPTVELFVYDLASGKTVEVVPPDDLSDAD----YYITRVKWVPD 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019   398 GtTVWVQVMSRDQAQCSLLLIPytdfllpeelggsikednlqlsTDLNMGVWDdksHEETmekpprgklrgtvqihkarN 477
Cdd:pfam00930 194 G-KLLVQWLNRDQNRLKVVLCD----------------------AETGRTVVI---LEET-------------------S 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019   478 DYWINTHNAIYPLKITDeehpmYEFIYCLEKPNGSCLALISAELdqngycrhTEEKLLMAENFSINKSMGivVDEVRELV 557
Cdd:pfam00930 229 DGWVELHQDPHFIKRDG-----SGFLWISERDGYNHLYLYDLDG--------KSPIQLTSGNWEVTSILG--VDETRDLV 293

                         330
                  ....*....|....*...
gi 17508019   558 YYVANESHPTEWNI-CVS 574
Cdd:pfam00930 294 YFTATEDSPTERHLySVS 311
 
Name Accession Description Interval E-value
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
706-914 1.94e-68

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 226.73  E-value: 1.94e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019   706 NDFSWIQYIrFCRLGYVVVFIDNRGSAHRGIEFERHIHKKMGTVEVEDQVEGLQMLAERtgGFMDMSRVVVHGWSYGGYM 785
Cdd:pfam00326   1 PSFSWNAQL-LADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQ--GYTDPDRLAIWGGSYGGYL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019   786 ALQMIAKHPNIYRAAIAGGAVSDWRLYDT----AYTERYMGYP---LEEHVY-GASSITGLVEKLpdEPNRLMLVHGLMD 857
Cdd:pfam00326  78 TGAALNQRPDLFKAAVAHVPVVDWLAYMSdtslPFTERYMEWGnpwDNEEGYdYLSPYSPADNVK--VYPPLLLIHGLLD 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 17508019   858 ENVHFAHLTHLVDECIKKGKWHELVIFPNERHGVRNNDASIYLDARMMYFAQQAIQG 914
Cdd:pfam00326 156 DRVPPWQSLKLVAALQRKGVPFLLLIFPDEGHGIGKPRNKVEEYARELAFLLEYLGG 212
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
670-909 1.31e-51

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 180.98  E-value: 1.31e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019 670 GLMHYAMILRPsnfDPYKKYPVFHYVYGGPGIQIVHNDFsWIQYirFCRLGYVVVFIDNRGSAHRGieferhihKKMGTV 749
Cdd:COG1506   7 GTTLPGWLYLP---ADGKKYPVVVYVHGGPGSRDDSFLP-LAQA--LASRGYAVLAPDYRGYGESA--------GDWGGD 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019 750 EVEDQVEGLQMLAERtgGFMDMSRVVVHGWSYGGYMALQMIAKHPNIYRAAIAGGAVSDWRLYDT---AYTERYMGYPLE 826
Cdd:COG1506  73 EVDDVLAAIDYLAAR--PYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYGttrEYTERLMGGPWE 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019 827 -EHVYGASSITGLVEKLPDepnRLMLVHGLMDENVHFAHLTHLVDECIKKGKWHELVIFPNERHGVRNNDASIYLDARMM 905
Cdd:COG1506 151 dPEAYAARSPLAYADKLKT---PLLLIHGEADDRVPPEQAERLYEALKKAGKPVELLVYPGEGHGFSGAGAPDYLERILD 227


                ....
gi 17508019 906 YFAQ 909
Cdd:COG1506 228 FLDR 231
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 245-574 1.52e-26

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 112.03  E-value: 1.52e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019   245 PPTNNFVSSAKVCPaDSSLLAYVLNKQVYIEK--NGKIIHRTSSNSKHITNGVPSYIVQEE-LERFEGIWWSESKTRLLY 321
Cdd:pfam00930  39 PPGEGKIQDAKWSP-DGDRLAFVRDNNLYVRElaTGKEIQITSDGSDGIFNGVADWVYEEEvLGSNSAVWWSPDGSRLAF 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019   322 EHVNEEKVAESQFGVNGDPPVAP----MKYPRAGTKNAYSTLRMVILENGKAYDVPLKDEVIYKHcpfyEYITRAGFFSD 397
Cdd:pfam00930 118 LRFDESEVPIITLPYYTDEGPGPevreIKYPKAGAPNPTVELFVYDLASGKTVEVVPPDDLSDAD----YYITRVKWVPD 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019   398 GtTVWVQVMSRDQAQCSLLLIPytdfllpeelggsikednlqlsTDLNMGVWDdksHEETmekpprgklrgtvqihkarN 477
Cdd:pfam00930 194 G-KLLVQWLNRDQNRLKVVLCD----------------------AETGRTVVI---LEET-------------------S 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019   478 DYWINTHNAIYPLKITDeehpmYEFIYCLEKPNGSCLALISAELdqngycrhTEEKLLMAENFSINKSMGivVDEVRELV 557
Cdd:pfam00930 229 DGWVELHQDPHFIKRDG-----SGFLWISERDGYNHLYLYDLDG--------KSPIQLTSGNWEVTSILG--VDETRDLV 293

                         330
                  ....*....|....*...
gi 17508019   558 YYVANESHPTEWNI-CVS 574
Cdd:pfam00930 294 YFTATEDSPTERHLySVS 311
 
Name Accession Description Interval E-value
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
706-914 1.94e-68

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 226.73  E-value: 1.94e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019   706 NDFSWIQYIrFCRLGYVVVFIDNRGSAHRGIEFERHIHKKMGTVEVEDQVEGLQMLAERtgGFMDMSRVVVHGWSYGGYM 785
Cdd:pfam00326   1 PSFSWNAQL-LADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQ--GYTDPDRLAIWGGSYGGYL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019   786 ALQMIAKHPNIYRAAIAGGAVSDWRLYDT----AYTERYMGYP---LEEHVY-GASSITGLVEKLpdEPNRLMLVHGLMD 857
Cdd:pfam00326  78 TGAALNQRPDLFKAAVAHVPVVDWLAYMSdtslPFTERYMEWGnpwDNEEGYdYLSPYSPADNVK--VYPPLLLIHGLLD 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 17508019   858 ENVHFAHLTHLVDECIKKGKWHELVIFPNERHGVRNNDASIYLDARMMYFAQQAIQG 914
Cdd:pfam00326 156 DRVPPWQSLKLVAALQRKGVPFLLLIFPDEGHGIGKPRNKVEEYARELAFLLEYLGG 212
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
670-909 1.31e-51

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 180.98  E-value: 1.31e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019 670 GLMHYAMILRPsnfDPYKKYPVFHYVYGGPGIQIVHNDFsWIQYirFCRLGYVVVFIDNRGSAHRGieferhihKKMGTV 749
Cdd:COG1506   7 GTTLPGWLYLP---ADGKKYPVVVYVHGGPGSRDDSFLP-LAQA--LASRGYAVLAPDYRGYGESA--------GDWGGD 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019 750 EVEDQVEGLQMLAERtgGFMDMSRVVVHGWSYGGYMALQMIAKHPNIYRAAIAGGAVSDWRLYDT---AYTERYMGYPLE 826
Cdd:COG1506  73 EVDDVLAAIDYLAAR--PYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYGttrEYTERLMGGPWE 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019 827 -EHVYGASSITGLVEKLPDepnRLMLVHGLMDENVHFAHLTHLVDECIKKGKWHELVIFPNERHGVRNNDASIYLDARMM 905
Cdd:COG1506 151 dPEAYAARSPLAYADKLKT---PLLLIHGEADDRVPPEQAERLYEALKKAGKPVELLVYPGEGHGFSGAGAPDYLERILD 227


                ....
gi 17508019 906 YFAQ 909
Cdd:COG1506 228 FLDR 231
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 245-574 1.52e-26

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 112.03  E-value: 1.52e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019   245 PPTNNFVSSAKVCPaDSSLLAYVLNKQVYIEK--NGKIIHRTSSNSKHITNGVPSYIVQEE-LERFEGIWWSESKTRLLY 321
Cdd:pfam00930  39 PPGEGKIQDAKWSP-DGDRLAFVRDNNLYVRElaTGKEIQITSDGSDGIFNGVADWVYEEEvLGSNSAVWWSPDGSRLAF 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019   322 EHVNEEKVAESQFGVNGDPPVAP----MKYPRAGTKNAYSTLRMVILENGKAYDVPLKDEVIYKHcpfyEYITRAGFFSD 397
Cdd:pfam00930 118 LRFDESEVPIITLPYYTDEGPGPevreIKYPKAGAPNPTVELFVYDLASGKTVEVVPPDDLSDAD----YYITRVKWVPD 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019   398 GtTVWVQVMSRDQAQCSLLLIPytdfllpeelggsikednlqlsTDLNMGVWDdksHEETmekpprgklrgtvqihkarN 477
Cdd:pfam00930 194 G-KLLVQWLNRDQNRLKVVLCD----------------------AETGRTVVI---LEET-------------------S 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019   478 DYWINTHNAIYPLKITDeehpmYEFIYCLEKPNGSCLALISAELdqngycrhTEEKLLMAENFSINKSMGivVDEVRELV 557
Cdd:pfam00930 229 DGWVELHQDPHFIKRDG-----SGFLWISERDGYNHLYLYDLDG--------KSPIQLTSGNWEVTSILG--VDETRDLV 293

                         330
                  ....*....|....*...
gi 17508019   558 YYVANESHPTEWNI-CVS 574
Cdd:pfam00930 294 YFTATEDSPTERHLySVS 311
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
660-915 8.88e-09

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 56.90  E-value: 8.88e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019 660 EMIEFQSKKTGLMHyAMILRPSNFDPYkkypvfhyvyggPGIQIVHNDFSWIQYI-----RFCRLGYVVVFIDNRGSAHR 734
Cdd:COG0412   4 ETVTIPTPDGVTLP-GYLARPAGGGPR------------PGVVVLHEIFGLNPHIrdvarRLAAAGYVVLAPDLYGRGGP 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019 735 GIEFERhIHKKMGTVEVEDQVE----GLQMLAERtgGFMDMSRVVVHGWSYGGYMALQMIAKHPNIyRAAIAggavsdwr 810
Cdd:COG0412  71 GDDPDE-ARALMGALDPELLAAdlraALDWLKAQ--PEVDAGRVGVVGFCFGGGLALLAAARGPDL-AAAVS-------- 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019 811 lydtayteRYMGYPLEEHVYGASSITGlveklpdepnRLMLVHGLMDENVHFAHLTHLVDECIKKGKWHELVIFPNERHG 890
Cdd:COG0412 139 --------FYGGLPADDLLDLAARIKA----------PVLLLYGEKDPLVPPEQVAALEAALAAAGVDVELHVYPGAGHG 200

                       250       260
                ....*....|....*....|....*
gi 17508019 891 VRNNDASIYlDARMMYFAQQAIQGF 915
Cdd:COG0412 201 FTNPGRPRY-DPAAAEDAWQRTLAF 224
COG4099 COG4099
Predicted peptidase [General function prediction only];
657-891 1.07e-08

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 56.90  E-value: 1.07e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019 657 DSPEMIEFQSKKTGL-MHYAmILRPSNFDPYKKYPVFHYVYGG------PGIQIVHNDFSWIQYIRFCRLGYVVVFidnr 729
Cdd:COG4099  17 DGFEARTFTDPSDGDtLPYR-LYLPKGYDPGKKYPLVLFLHGAgergtdNEKQLTHGAPKFINPENQAKFPAIVLA---- 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019 730 gsahrgiefeRHIHKKMG--TVEVEDQVEGLQMLAERTGGfMDMSRVVVHGWSYGGYMALQMIAKHPNIYRAA--IAGGA 805
Cdd:COG4099  92 ----------PQCPEDDYwsDTKALDAVLALLDDLIAEYR-IDPDRIYLTGLSMGGYGTWDLAARYPDLFAAAvpICGGG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019 806 vsdwrlyDTAYTERYmgypleehvygassitglvEKLPdepnrLMLVHGLMDENVHFAHLTHLVDECIKKGKWHELVIFP 885
Cdd:COG4099 161 -------DPANAANL-------------------KKVP-----VWIFHGAKDDVVPVEESRAMVEALKAAGADVKYTEYP 209


                ....*.
gi 17508019 886 NERHGV 891
Cdd:COG4099 210 GVGHNS 215
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
625-802 4.55e-08

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 56.01  E-value: 4.55e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019 625 SFRWKENEVLPSTVYAANITVSGHPGQPDLHFDSPEMIEFQSKKTGLMHYAMILRPSNFD-PYKKYPVFhYVYGGPGiqi 703
Cdd:COG2382  47 AAAARLLAPVVAAAVVVLGGPPPATDDKDVPHGTVETVTYPSKALGRTRRVWVYLPPGYDnPGKKYPVL-YLLDGGG--- 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019 704 vHNDFSWIQYIRFCRL-----------GYVVVFIDNRGSAHRGIE------FERHIHKkmgtvEVedqvegLQMLAERTG 766
Cdd:COG2382 123 -GDEQDWFDQGRLPTIldnliaagkipPMIVVMPDGGDGGDRGTEgpgndaFERFLAE-----EL------IPFVEKNYR 190

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 17508019 767 GFMDMSRVVVHGWSYGGYMALQMIAKHPNIYRAAIA 802
Cdd:COG2382 191 VSADPEHRAIAGLSMGGLAALYAALRHPDLFGYVGS 226
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
698-893 2.39e-06

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 49.62  E-value: 2.39e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019 698 GPGIQIVH----NDFSWIQYIR-FCRLGYVVVFIDNRG---SAHRGIEFERhihkkMGTVeVEDQVEGLQMLAERTGGfm 769
Cdd:COG2267  28 RGTVVLVHglgeHSGRYAELAEaLAAAGYAVLAFDLRGhgrSDGPRGHVDS-----FDDY-VDDLRAALDALRARPGL-- 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019 770 dmsRVVVHGWSYGGYMALQMIAKHPNIYRAAIAGGAVSDWRLYDTAYTERYMGYPLEEHvygASSITglvekLPdepnrL 849
Cdd:COG2267 100 ---PVVLLGHSMGGLIALLYAARYPDRVAGLVLLAPAYRADPLLGPSARWLRALRLAEA---LARID-----VP-----V 163

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 17508019 850 MLVHGLMDENVHFAHLTHLVDECIKKGkwhELVIFPNERHGVRN 893
Cdd:COG2267 164 LVLHGGADRVVPPEAARRLAARLSPDV---ELVLLPGARHELLN 204
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 720-891 6.85e-06

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 48.07  E-value: 6.85e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019 720 GYVVVFIDNRGsahrgieferhihkkMGTVEVEDQVEGLQMLAERTGGFMD---MSRVVVHGWSYGGYMALQMIAKHPNI 796
Cdd:COG0596  49 GYRVIAPDLRG---------------HGRSDKPAGGYTLDDLADDLAALLDalgLERVVLVGHSMGGMVALELAARHPER 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019 797 YRAAIAGGAVSDWrlYDTAYTERYMGYPLEEHVYGASSITGLVEKLPDEPNRLMLVHGLMDENVHFAHLTHLVdECIKKG 876
Cdd:COG0596 114 VAGLVLVDEVLAA--LAEPLRRPGLAPEALAALLRALARTDLRERLARITVPTLVIWGEKDPIVPPALARRLA-ELLPNA 190

                       170
                ....*....|....*
gi 17508019 877 kwhELVIFPNERHGV 891
Cdd:COG0596 191 ---ELVVLPGAGHFP 202
FrmB COG0627
S-formylglutathione hydrolase FrmB [Defense mechanisms];
662-844 1.04e-05

S-formylglutathione hydrolase FrmB [Defense mechanisms];


Pssm-ID: 440392 [Multi-domain]  Cd Length: 249  Bit Score: 47.90  E-value: 1.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019 662 IEFQSKKTGLMHYAMILRPSNFDPyKKYPVFHYVYGGPGiqivhNDFSWIQYI---RFC-RLGYVVVFID-NRGS----A 732
Cdd:COG0627   7 VTVPSPALGREMPVSVYLPPGYDG-RPLPVLYLLHGLTG-----THENWTRKTgaqRLAaELGVIVVMPDgGQASfyvdW 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019 733 HRGIE----FERHIhkkmgTVEVedqvegLQMLAERTGGFMDMSRVVVHGWSYGGYMALQMIAKHPNIYRA--AIAGGAV 806
Cdd:COG0627  81 TQGPAghyrWETYL-----TEEL------PPLIEANFPVSADRERRAIAGLSMGGHGALTLALRHPDLFRAvaAFSGILD 149

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 17508019 807 SDWRLYDTAYTERYMGYPLEEhVYGASSITGLVEKLPD 844
Cdd:COG0627 150 PSQPPWGEKAFDAYFGPPDRA-AWAANDPLALAEKLRA 186
LpqC COG3509
Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and ...
 677-870 3.12e-05

Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and metabolism];


Pssm-ID: 442732 [Multi-domain]  Cd Length: 284  Bit Score: 46.92  E-value: 3.12e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019 677 ILRPSNFDPYKKYPV---FHYvYGGPGIQIVHNdFSWIQYIRfcRLGYVVVFID-NRGSAHRGIEFERHIHKKMGTVEVE 752
Cdd:COG3509  41 LYVPAGYDGGAPLPLvvaLHG-CGGSAADFAAG-TGLNALAD--REGFIVVYPEgTGRAPGRCWNWFDGRDQRRGRDDVA 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019 753 --DQVegLQMLAERTGGfmDMSRVVVHGWSYGGYMALQMIAKHPNIYRA--AIAGGAVSDWRLYDTAyterymgypleeh 828
Cdd:COG3509 117 fiAAL--VDDLAARYGI--DPKRVYVTGLSAGGAMAYRLACEYPDVFAAvaPVAGLPYGAASDAACA------------- 179

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 17508019 829 vygassitglveklPDEPNRLMLVHGLMDENVHFAHLTHLVD 870
Cdd:COG3509 180 --------------PGRPVPVLVIHGTADPTVPYAGAEETLA 207
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 687-911 7.27e-05

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 45.29  E-value: 7.27e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019 687 KKYPVFHYVYGGPGiqivhNDFSWIQYI-RFCRLGYVVVFIDNRG---SAHRGIEferhihkkMGTVEVEDQVEGLQMLA 762
Cdd:COG1073  35 KKYPAVVVAHGNGG-----VKEQRALYAqRLAELGFNVLAFDYRGygeSEGEPRE--------EGSPERRDARAAVDYLR 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019 763 ERTGGfmDMSRVVVHGWSYGGYMALQMIAKHPNIyrAAIA-------GGAVSDWRLYDtAYTERYMGYPLEEHVYGASSI 835
Cdd:COG1073 102 TLPGV--DPERIGLLGISLGGGYALNAAATDPRV--KAVIldspftsLEDLAAQRAKE-ARGAYLPGVPYLPNVRLASLL 176

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17508019 836 TG---LVEKLPDEPNRLMLVHGLMDENVHFAHLTHLVDECiKKGKwhELVIFPNERHgvrnNDAsiYLDARMMYFAQQA 911
Cdd:COG1073 177 NDefdPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAA-AEPK--ELLIVPGAGH----VDL--YDRPEEEYFDKLA 246
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
677-890 9.27e-05

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 44.48  E-value: 9.27e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019 677 ILRPSnfDPYKKYPVFHYVYGGpgiqivhndfSWI-----QYIRFCR-----LGYVVVFIDNR-GSAHRgieFErhihkk 745
Cdd:COG0657   3 VYRPA--GAKGPLPVVVYFHGG----------GWVsgskdTHDPLARrlaarAGAAVVSVDYRlAPEHP---FP------ 61

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019 746 mgtVEVEDQVEGLQMLAERTGGF-MDMSRVVVHGWSYGGYMALQMIAKHPNIYRAAIAgGAVSDWRLYDtayterymgyp 824
Cdd:COG0657  62 ---AALEDAYAALRWLRANAAELgIDPDRIAVAGDSAGGHLAAALALRARDRGGPRPA-AQVLIYPVLD----------- 126

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019 825 leehvYGASSITGLVEKLPdepnRLMLVHG----LMDENVHFAhlthlvDECIKKGKWHELVIFPNERHG 890
Cdd:COG0657 127 -----LTASPLRADLAGLP----PTLIVTGeadpLVDESEALA------AALRAAGVPVELHVYPGGGHG 181
YpfH COG0400
Predicted esterase [General function prediction only];
758-892 3.45e-04

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 42.59  E-value: 3.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508019 758 LQMLAERTGgfMDMSRVVVHGWSYGGYMALQMIAKHPNIYRAAIA-GGavsdwrlydtayterymGYPLEEHVYGASSIT 836
Cdd:COG0400  77 IDELEARYG--IDPERIVLAGFSQGAAMALSLALRRPELLAGVVAlSG-----------------YLPGEEALPAPEAAL 137

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 17508019 837 GLVeklpdepnRLMLVHGLMDENVHFAHLTHLVDECIKKGKWHELVIFPNErHGVR 892
Cdd:COG0400 138 AGT--------PVFLAHGTQDPVIPVERAREAAEALEAAGADVTYREYPGG-HEIS 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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