NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|71993616|ref|NP_493247|]
View 

putative cytosolic iron-sulfur protein assembly protein CIAO1 homolog [Caenorhabditis elegans]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
17-336 6.16e-51

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.94  E-value: 6.16e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616  17 TSRVWMTCWHHGGRILASCGDDKAVRVWSLVGepdskmrLECRTTLDDsHTRAVRSVAFSNDGKCLVSASFDASVVVYQQ 96
Cdd:COG2319 120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLAT-------GKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616  97 EDGEfaEVNKLEGHESEVKCAVFSKSDEFLATCSRDKSVWFWQQDEDEdfsVSSILQPHTQDVKQVAWHPTEDLLVSCSY 176
Cdd:COG2319 192 ATGK--LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK---LLRTLTGHSGSVRSVAFSPDGRLLASGSA 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616 177 DSSIRFYRFDGEDWVtqQKIDGcHVGTVWSIAFDTEGHRLVTVGEDHCIQLFvrenigsksaDQDTWKSVARYdvENTRW 256
Cdd:COG2319 267 DGTVRLWDLATGELL--RTLTG-HSGGVNSVAFSPDGKLLASGSDDGTVRLW----------DLATGKLLRTL--TGHTG 331

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616 257 PLYSVAWNSTNDVIATGGGDCKIRLFKISSTPEspviehLGVVGRHELDVNHVAWNPNpkfSNLLTSASDDGTIRLWELE 336
Cdd:COG2319 332 AVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL------LRTLTGHTGAVTSVAFSPD---GRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
17-336 6.16e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.94  E-value: 6.16e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616  17 TSRVWMTCWHHGGRILASCGDDKAVRVWSLVGepdskmrLECRTTLDDsHTRAVRSVAFSNDGKCLVSASFDASVVVYQQ 96
Cdd:COG2319 120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLAT-------GKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616  97 EDGEfaEVNKLEGHESEVKCAVFSKSDEFLATCSRDKSVWFWQQDEDEdfsVSSILQPHTQDVKQVAWHPTEDLLVSCSY 176
Cdd:COG2319 192 ATGK--LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK---LLRTLTGHSGSVRSVAFSPDGRLLASGSA 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616 177 DSSIRFYRFDGEDWVtqQKIDGcHVGTVWSIAFDTEGHRLVTVGEDHCIQLFvrenigsksaDQDTWKSVARYdvENTRW 256
Cdd:COG2319 267 DGTVRLWDLATGELL--RTLTG-HSGGVNSVAFSPDGKLLASGSDDGTVRLW----------DLATGKLLRTL--TGHTG 331

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616 257 PLYSVAWNSTNDVIATGGGDCKIRLFKISSTPEspviehLGVVGRHELDVNHVAWNPNpkfSNLLTSASDDGTIRLWELE 336
Cdd:COG2319 332 AVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL------LRTLTGHTGAVTSVAFSPD---GRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-334 2.19e-50

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 169.44  E-value: 2.19e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616  17 TSRVWMTCWHHGGRILASCGDDKAVRVWSLvgEPDSKMRLECrttlddSHTRAVRSVAFSNDGKCLVSASFDASVVVYQQ 96
Cdd:cd00200   9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDL--ETGELLRTLK------GHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616  97 EDGEfaEVNKLEGHESEVKCAVFSKSDEFLATCSRDKSVWFWqqdEDEDFSVSSILQPHTQDVKQVAWHPTEDLLVSCSY 176
Cdd:cd00200  81 ETGE--CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVW---DVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQ 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616 177 DSSIRFYrfDGEDWVTQQKIDGcHVGTVWSIAFDTEGHRLVTVGEDHCIQLFvrenigsksaDQDTWKSVARYDVENTrw 256
Cdd:cd00200 156 DGTIKLW--DLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSSSSDGTIKLW----------DLSTGKCLGTLRGHEN-- 220

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71993616 257 PLYSVAWNSTNDVIATGGGDCKIRLFKISSTpespviEHLGVVGRHELDVNHVAWNPNPKFsnlLTSASDDGTIRLWE 334
Cdd:cd00200 221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTG------ECVQTLSGHTNSVTSLAWSPDGKR---LASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 145-183 2.22e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 2.22e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 71993616    145 DFSVSSILQPHTQDVKQVAWHPTEDLLVSCSYDSSIRFY 183
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
104-138 7.93e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 7.93e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 71993616   104 VNKLEGHESEVKCAVFSKSDEFLATCSRDKSVWFW 138
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 104-188 7.85e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.09  E-value: 7.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616  104 VNKLEGHESEVKCAVFSKS-DEFLATCSRDKSVWFWQ-QDEDEdfSVSSILQP------HTQDVKQVAWHPTED-LLVSC 174
Cdd:PTZ00420  67 VIKLKGHTSSILDLQFNPCfSEILASGSEDLTIRVWEiPHNDE--SVKEIKDPqcilkgHKKKISIIDWNPMNYyIMCSS 144

                         90
                 ....*....|....
gi 71993616  175 SYDSSIRFYRFDGE 188
Cdd:PTZ00420 145 GFDSFVNIWDIENE 158
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
17-336 6.16e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.94  E-value: 6.16e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616  17 TSRVWMTCWHHGGRILASCGDDKAVRVWSLVGepdskmrLECRTTLDDsHTRAVRSVAFSNDGKCLVSASFDASVVVYQQ 96
Cdd:COG2319 120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLAT-------GKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616  97 EDGEfaEVNKLEGHESEVKCAVFSKSDEFLATCSRDKSVWFWQQDEDEdfsVSSILQPHTQDVKQVAWHPTEDLLVSCSY 176
Cdd:COG2319 192 ATGK--LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK---LLRTLTGHSGSVRSVAFSPDGRLLASGSA 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616 177 DSSIRFYRFDGEDWVtqQKIDGcHVGTVWSIAFDTEGHRLVTVGEDHCIQLFvrenigsksaDQDTWKSVARYdvENTRW 256
Cdd:COG2319 267 DGTVRLWDLATGELL--RTLTG-HSGGVNSVAFSPDGKLLASGSDDGTVRLW----------DLATGKLLRTL--TGHTG 331

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616 257 PLYSVAWNSTNDVIATGGGDCKIRLFKISSTPEspviehLGVVGRHELDVNHVAWNPNpkfSNLLTSASDDGTIRLWELE 336
Cdd:COG2319 332 AVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL------LRTLTGHTGAVTSVAFSPD---GRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-334 2.19e-50

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 169.44  E-value: 2.19e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616  17 TSRVWMTCWHHGGRILASCGDDKAVRVWSLvgEPDSKMRLECrttlddSHTRAVRSVAFSNDGKCLVSASFDASVVVYQQ 96
Cdd:cd00200   9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDL--ETGELLRTLK------GHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616  97 EDGEfaEVNKLEGHESEVKCAVFSKSDEFLATCSRDKSVWFWqqdEDEDFSVSSILQPHTQDVKQVAWHPTEDLLVSCSY 176
Cdd:cd00200  81 ETGE--CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVW---DVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQ 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616 177 DSSIRFYrfDGEDWVTQQKIDGcHVGTVWSIAFDTEGHRLVTVGEDHCIQLFvrenigsksaDQDTWKSVARYDVENTrw 256
Cdd:cd00200 156 DGTIKLW--DLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSSSSDGTIKLW----------DLSTGKCLGTLRGHEN-- 220

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71993616 257 PLYSVAWNSTNDVIATGGGDCKIRLFKISSTpespviEHLGVVGRHELDVNHVAWNPNPKFsnlLTSASDDGTIRLWE 334
Cdd:cd00200 221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTG------ECVQTLSGHTNSVTSLAWSPDGKR---LASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
17-336 9.49e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 170.86  E-value: 9.49e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616  17 TSRVWMTCWHHGGRILASCGDDKAVRVWSLVGEpdskmrlECRTTLDDsHTRAVRSVAFSNDGKCLVSASFDASVVVYQQ 96
Cdd:COG2319  78 TAAVLSVAFSPDGRLLASASADGTVRLWDLATG-------LLLRTLTG-HTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616  97 EDGEfaEVNKLEGHESEVKCAVFSKSDEFLATCSRDKSVWFWQQDEDEDFSVssiLQPHTQDVKQVAWHPTEDLLVSCSY 176
Cdd:COG2319 150 ATGK--LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT---LTGHTGAVRSVAFSPDGKLLASGSA 224

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616 177 DSSIRFYRFDGEDWVtqQKIDGcHVGTVWSIAFDTEGHRLVTVGEDHCIQLFvrenigsksaDQDTWKSVARYDVENtrW 256
Cdd:COG2319 225 DGTVRLWDLATGKLL--RTLTG-HSGSVRSVAFSPDGRLLASGSADGTVRLW----------DLATGELLRTLTGHS--G 289

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616 257 PLYSVAWNSTNDVIATGGGDCKIRLFKISSTpespviEHLGVVGRHELDVNHVAWNPNPKFsnlLTSASDDGTIRLWELE 336
Cdd:COG2319 290 GVNSVAFSPDGKLLASGSDDGTVRLWDLATG------KLLRTLTGHTGAVRSVAFSPDGKT---LASGSDDGTVRLWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
17-286 2.84e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.22  E-value: 2.84e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616  17 TSRVWMTCWHHGGRILASCGDDKAVRVWSLVGepdskmrLECRTTLDDsHTRAVRSVAFSNDGKCLVSASFDASVVVYQQ 96
Cdd:COG2319 162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT-------GKLLRTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616  97 EDGEfaEVNKLEGHESEVKCAVFSKSDEFLATCSRDKSVWFWQQDEDEdfsVSSILQPHTQDVKQVAWHPTEDLLVSCSY 176
Cdd:COG2319 234 ATGK--LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE---LLRTLTGHSGGVNSVAFSPDGKLLASGSD 308

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616 177 DSSIRFYrfDGEDWVTQQKIDGcHVGTVWSIAFDTEGHRLVTVGEDHCIQLFvrenigsksaDQDTWKSVARYdvENTRW 256
Cdd:COG2319 309 DGTVRLW--DLATGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSDDGTVRLW----------DLATGELLRTL--TGHTG 373

                       250       260       270
                ....*....|....*....|....*....|
gi 71993616 257 PLYSVAWNSTNDVIATGGGDCKIRLFKISS 286
Cdd:COG2319 374 AVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 58-336 4.93e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 139.78  E-value: 4.93e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616  58 CRTTLDdSHTRAVRSVAFSNDGKCLVSASFDASVVVYQQEDGEFaeVNKLEGHESEVKCAVFSKSDEFLATCSRDKSVWF 137
Cdd:cd00200   1 LRRTLK-GHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL--LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616 138 WQQdedEDFSVSSILQPHTQDVKQVAWHPTEDLLVSCSYDSSIRFyrFDGEDWVTQQKIDGcHVGTVWSIAFDTEGHRLV 217
Cdd:cd00200  78 WDL---ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKV--WDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVA 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616 218 TVGEDHCIQLFvrenigsksaDQDTWKSVARYDVENTrwPLYSVAWNSTNDVIATGGGDCKIRLFKISSTpespviEHLG 297
Cdd:cd00200 152 SSSQDGTIKLW----------DLRTGKCVATLTGHTG--EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG------KCLG 213

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 71993616 298 VVGRHELDVNHVAWNPNpkfSNLLTSASDDGTIRLWELE 336
Cdd:cd00200 214 TLRGHENGVNSVAFSPD---GYLLASGSEDGTIRVWDLR 249
WD40 COG2319
WD40 repeat [General function prediction only];
14-227 6.31e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 139.66  E-value: 6.31e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616  14 KDDTSRVWMTCWHHGGRILASCGDDKAVRVWSLVGEpdskmrlECRTTLDDsHTRAVRSVAFSNDGKCLVSASFDASVVV 93
Cdd:COG2319 201 TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG-------KLLRTLTG-HSGSVRSVAFSPDGRLLASGSADGTVRL 272

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616  94 YQQEDGEfaEVNKLEGHESEVKCAVFSKSDEFLATCSRDKSVWFWQQDEDEDFSVssiLQPHTQDVKQVAWHPTEDLLVS 173
Cdd:COG2319 273 WDLATGE--LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT---LTGHTGAVRSVAFSPDGKTLAS 347

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 71993616 174 CSYDSSIRFYrfDGEDWVTQQKIDGcHVGTVWSIAFDTEGHRLVTVGEDHCIQL 227
Cdd:COG2319 348 GSDDGTVRLW--DLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
25-336 2.27e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.12  E-value: 2.27e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616  25 WHHGGRILASCGDDKAVRVWSLVGEPDSKMRLecrttlddSHTRAVRSVAFSNDGKCLVSASFDASVVVYQQEDGEfaEV 104
Cdd:COG2319  44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLL--------GHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL--LL 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616 105 NKLEGHESEVKCAVFSKSDEFLATCSRDKSVWFWQQDEDEdfsVSSILQPHTQDVKQVAWHPTEDLLVSCSYDSSIRFYr 184
Cdd:COG2319 114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK---LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW- 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616 185 fDGEDWVTQQKIDGcHVGTVWSIAFDTEGHRLVTVGEDHCIQLFvrenigsksaDQDTWKSVARYDVENtrWPLYSVAWN 264
Cdd:COG2319 190 -DLATGKLLRTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLW----------DLATGKLLRTLTGHS--GSVRSVAFS 255

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71993616 265 STNDVIATGGGDCKIRLFKISSTpespviEHLGVVGRHELDVNHVAWNPNpkfSNLLTSASDDGTIRLWELE 336
Cdd:COG2319 256 PDGRLLASGSADGTVRLWDLATG------ELLRTLTGHSGGVNSVAFSPD---GKLLASGSDDGTVRLWDLA 318
WD40 COG2319
WD40 repeat [General function prediction only];
14-187 3.36e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.78  E-value: 3.36e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616  14 KDDTSRVWMTCWHHGGRILASCGDDKAVRVWSLVGEpdskmrlECRTTLDDsHTRAVRSVAFSNDGKCLVSASFDASVVV 93
Cdd:COG2319 243 TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG-------ELLRTLTG-HSGGVNSVAFSPDGKLLASGSDDGTVRL 314

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616  94 YQQEDGEfaEVNKLEGHESEVKCAVFSKSDEFLATCSRDKSVWFWQQDEDEdfsVSSILQPHTQDVKQVAWHPTEDLLVS 173
Cdd:COG2319 315 WDLATGK--LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE---LLRTLTGHTGAVTSVAFSPDGRTLAS 389

                       170
                ....*....|....
gi 71993616 174 CSYDSSIRFYRFDG 187
Cdd:COG2319 390 GSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 145-183 2.22e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 2.22e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 71993616    145 DFSVSSILQPHTQDVKQVAWHPTEDLLVSCSYDSSIRFY 183
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 104-138 2.26e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 2.26e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 71993616    104 VNKLEGHESEVKCAVFSKSDEFLATCSRDKSVWFW 138
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
104-138 7.93e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 7.93e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 71993616   104 VNKLEGHESEVKCAVFSKSDEFLATCSRDKSVWFW 138
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 294-334 3.77e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 3.77e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 71993616    294 EHLGVVGRHELDVNHVAWNPNpkfSNLLTSASDDGTIRLWE 334
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPD---GKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 57-94 4.82e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 4.82e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 71993616     57 ECRTTLDdSHTRAVRSVAFSNDGKCLVSASFDASVVVY 94
Cdd:smart00320   3 ELLKTLK-GHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
151-183 5.09e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 5.09e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 71993616   151 ILQPHTQDVKQVAWHPTEDLLVSCSYDSSIRFY 183
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 104-188 7.85e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.09  E-value: 7.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993616  104 VNKLEGHESEVKCAVFSKS-DEFLATCSRDKSVWFWQ-QDEDEdfSVSSILQP------HTQDVKQVAWHPTED-LLVSC 174
Cdd:PTZ00420  67 VIKLKGHTSSILDLQFNPCfSEILASGSEDLTIRVWEiPHNDE--SVKEIKDPqcilkgHKKKISIIDWNPMNYyIMCSS 144

                         90
                 ....*....|....
gi 71993616  175 SYDSSIRFYRFDGE 188
Cdd:PTZ00420 145 GFDSFVNIWDIENE 158
WD40 pfam00400
WD domain, G-beta repeat;
294-334 1.15e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.15e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 71993616   294 EHLGVVGRHELDVNHVAWNPNpkfSNLLTSASDDGTIRLWE 334
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPD---GKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
57-94 1.85e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 1.85e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 71993616    57 ECRTTLDdSHTRAVRSVAFSNDGKCLVSASFDASVVVY 94
Cdd:pfam00400   2 KLLKTLE-GHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 14-45 2.70e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 2.70e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 71993616     14 KDDTSRVWMTCWHHGGRILASCGDDKAVRVWS 45
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH