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Conserved domains on  [gi|17507425|ref|NP_493454|]
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Glycerol-3-phosphate dehydrogenase [NAD(+)] [Caenorhabditis elegans]

Protein Classification

glycerol-3-phosphate dehydrogenase family protein( domain architecture ID 11496765)

glycerol-3-phosphate dehydrogenase family protein is similar to human L-alpha-glycerol-3-phosphate dehydrogenase 1 (GPD1), which catalyzes the reversible biological conversion of dihydroxyacetone (DHAP) to glycerol-3-phosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 23-367 9.02e-144

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


:

Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 410.96  E-value: 9.02e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425    23 KIAIVGGGNWGSAIACVVGKTVKAQDEVFQPIVSIWCRDSRKPGDlspSIAETINSTHENPKYLPGRRIPDNVVATSSLL 102
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALPELFEESVRMWVFEEEIEGR---NLTEIINTTHENVKYLPGIKLPANLVAVPDLV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425   103 EACQSAHILILVVPHQGIPQICDELRGKLQKGAHAISLTKGISSSCENgeikMQLISEDIERALGVQCSVLMGANLAGEV 182
Cdd:TIGR03376  78 EAAKGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEVSKDG----VKLLSDIIEEELGIPCGVLSGANLANEV 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425   183 ADGKFCEATIGCKSLKN----GEELKKVFDTPNFRIRVTTDYEAVELCGALKNIVACAAGFADGLGWAYNVKSAIIRLGL 258
Cdd:TIGR03376 154 AKEKFSETTVGYRDPADfdvdARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGL 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425   259 LETKKFVEHFYPSSVGHTYFESCGVADLITTCYGGRNRKVAEAFIKSDKPLRVIEQELLKGQSAQGPPTAQDVYEMLEIN 338
Cdd:TIGR03376 234 LEMIKFARMFFPTGEVTFTFESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNK 313

                         330       340
                  ....*....|....*....|....*....
gi 17507425   339 EISEKFPIFASVHKVFTGHHGEQELYDSL 367
Cdd:TIGR03376 314 NKDDEFPLFEAVYQILYEGLPPKKLPECL 342
 
Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 23-367 9.02e-144

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 410.96  E-value: 9.02e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425    23 KIAIVGGGNWGSAIACVVGKTVKAQDEVFQPIVSIWCRDSRKPGDlspSIAETINSTHENPKYLPGRRIPDNVVATSSLL 102
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALPELFEESVRMWVFEEEIEGR---NLTEIINTTHENVKYLPGIKLPANLVAVPDLV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425   103 EACQSAHILILVVPHQGIPQICDELRGKLQKGAHAISLTKGISSSCENgeikMQLISEDIERALGVQCSVLMGANLAGEV 182
Cdd:TIGR03376  78 EAAKGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEVSKDG----VKLLSDIIEEELGIPCGVLSGANLANEV 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425   183 ADGKFCEATIGCKSLKN----GEELKKVFDTPNFRIRVTTDYEAVELCGALKNIVACAAGFADGLGWAYNVKSAIIRLGL 258
Cdd:TIGR03376 154 AKEKFSETTVGYRDPADfdvdARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGL 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425   259 LETKKFVEHFYPSSVGHTYFESCGVADLITTCYGGRNRKVAEAFIKSDKPLRVIEQELLKGQSAQGPPTAQDVYEMLEIN 338
Cdd:TIGR03376 234 LEMIKFARMFFPTGEVTFTFESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNK 313

                         330       340
                  ....*....|....*....|....*....
gi 17507425   339 EISEKFPIFASVHKVFTGHHGEQELYDSL 367
Cdd:TIGR03376 314 NKDDEFPLFEAVYQILYEGLPPKKLPECL 342
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 22-369 4.84e-133

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 384.76  E-value: 4.84e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425   22 KKIAIVGGGNWGSAIACVVGKTVKaQDEVFQPIVSIWCRDSRKPGDlspSIAETINSTHENPKYLPGRRIPDNVVATSSL 101
Cdd:PTZ00345  12 LKVSVIGSGNWGSAISKVVGENTQ-RNYIFHNEVRMWVLEEIVEGE---KLSDIINTKHENVKYLPGIKLPDNIVAVSDL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425  102 LEACQSAHILILVVPHQGIPQICDELR--GKLQKGAHAISLTKGISssCENGeiKMQLISEDIERALGVQCSVLMGANLA 179
Cdd:PTZ00345  88 KEAVEDADLLIFVIPHQFLESVLSQIKenNNLKKHARAISLTKGII--VENG--KPVLCSDVIEEELGIPCCALSGANVA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425  180 GEVADGKFCEATIGCKSLKNGEELKKVFDTPNFRIRVTTDYEAVELCGALKNIVACAAGFADGLGWAYNVKSAIIRLGLL 259
Cdd:PTZ00345 164 NDVAREEFSEATIGCEDKDDALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTNTKSAIIRIGLE 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425  260 ETKKFVEHFYPSSVGHTYFESCGVADLITTCYGGRNRKVAEAFIKSD--KPLRVIEQELLKGQSAQGPPTAQDVYEMLEI 337
Cdd:PTZ00345 244 EMKLFGKIFFPNVMDETFFESCGLADLITTCLGGRNVRCAAEFAKRNgkKSWEEIEAELLNGQKLQGTVTLKEVYEVLES 323

                        330       340       350
                 ....*....|....*....|....*....|...
gi 17507425  338 NEISEKFPIFASVHKV-FTGHHGEqELYDSLRN 369
Cdd:PTZ00345 324 HDLKKEFPLFTVTYKIaFEGADPS-SLIDVLST 355
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 22-356 1.09e-79

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 247.26  E-value: 1.09e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425  22 KKIAIVGGGNWGSAIACVVGKtvKAQDevfqpiVSIWCRDsrkpgdlsPSIAETINSTHENPKYLPGRRIPDNVVATSSL 101
Cdd:COG0240   1 MKIAVLGAGSWGTALAKVLAR--NGHE------VTLWGRD--------PEVAEEINETRENPRYLPGVKLPENLRATSDL 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425 102 LEACQSAHILILVVPHQGIPQICDELRGKLQKGAHAISLTKGIssscENGEIKmqLISEDIERALG--VQCSVLMGANLA 179
Cdd:COG0240  65 EEALAGADLVLLAVPSQALREVLEQLAPLLPPGAPVVSATKGI----EPGTGL--LMSEVIAEELPgaLRIAVLSGPSFA 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425 180 GEVADGKFCEATIGCKSLKNGEELKKVFDTPNFRIRVTTDYEAVELCGALKNIVACAAGFADGLGWAYNVKSAIIRLGLL 259
Cdd:COG0240 139 EEVARGLPTAVVVASEDEEVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLA 218

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425 260 ETKKFVEHFYPSSvgHTYFESCGVADLITTCYG--GRNRKVAEAFIKSdKPLRVIEQELlkGQSAQGPPTAQDVYEMLEI 337
Cdd:COG0240 219 EMTRLGVALGARP--ETFMGLAGLGDLVLTCTSdlSRNRRFGLALGKG-KSLEEALAEM--GMVAEGVYTAKAVYELAEK 293

                       330
                ....*....|....*....
gi 17507425 338 NEIseKFPIFASVHKVFTG 356
Cdd:COG0240 294 LGV--EMPITEAVYAVLYE 310
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 223-356 1.16e-48

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 161.02  E-value: 1.16e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425   223 VELCGALKNIVACAAGFADGLGWAYNVKSAIIRLGLLETKKFVEHFYPSSvgHTYFESCGVADLITTCYGG--RNRKVAE 300
Cdd:pfam07479   5 VELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKALGAKP--ETFFGLAGLGDLIVTCTSGlsRNRRFGE 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 17507425   301 AFIKSdKPLRVIEQELlkGQSAQGPPTAQDVYEMLEINEIseKFPIFASVHKVFTG 356
Cdd:pfam07479  83 ALGKG-KSLEEAEKEL--GQVAEGVYTAKAVYELAKKLGV--EMPIFEAVYRILYE 133
 
Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 23-367 9.02e-144

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 410.96  E-value: 9.02e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425    23 KIAIVGGGNWGSAIACVVGKTVKAQDEVFQPIVSIWCRDSRKPGDlspSIAETINSTHENPKYLPGRRIPDNVVATSSLL 102
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALPELFEESVRMWVFEEEIEGR---NLTEIINTTHENVKYLPGIKLPANLVAVPDLV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425   103 EACQSAHILILVVPHQGIPQICDELRGKLQKGAHAISLTKGISSSCENgeikMQLISEDIERALGVQCSVLMGANLAGEV 182
Cdd:TIGR03376  78 EAAKGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEVSKDG----VKLLSDIIEEELGIPCGVLSGANLANEV 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425   183 ADGKFCEATIGCKSLKN----GEELKKVFDTPNFRIRVTTDYEAVELCGALKNIVACAAGFADGLGWAYNVKSAIIRLGL 258
Cdd:TIGR03376 154 AKEKFSETTVGYRDPADfdvdARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGL 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425   259 LETKKFVEHFYPSSVGHTYFESCGVADLITTCYGGRNRKVAEAFIKSDKPLRVIEQELLKGQSAQGPPTAQDVYEMLEIN 338
Cdd:TIGR03376 234 LEMIKFARMFFPTGEVTFTFESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNK 313

                         330       340
                  ....*....|....*....|....*....
gi 17507425   339 EISEKFPIFASVHKVFTGHHGEQELYDSL 367
Cdd:TIGR03376 314 NKDDEFPLFEAVYQILYEGLPPKKLPECL 342
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 22-369 4.84e-133

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 384.76  E-value: 4.84e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425   22 KKIAIVGGGNWGSAIACVVGKTVKaQDEVFQPIVSIWCRDSRKPGDlspSIAETINSTHENPKYLPGRRIPDNVVATSSL 101
Cdd:PTZ00345  12 LKVSVIGSGNWGSAISKVVGENTQ-RNYIFHNEVRMWVLEEIVEGE---KLSDIINTKHENVKYLPGIKLPDNIVAVSDL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425  102 LEACQSAHILILVVPHQGIPQICDELR--GKLQKGAHAISLTKGISssCENGeiKMQLISEDIERALGVQCSVLMGANLA 179
Cdd:PTZ00345  88 KEAVEDADLLIFVIPHQFLESVLSQIKenNNLKKHARAISLTKGII--VENG--KPVLCSDVIEEELGIPCCALSGANVA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425  180 GEVADGKFCEATIGCKSLKNGEELKKVFDTPNFRIRVTTDYEAVELCGALKNIVACAAGFADGLGWAYNVKSAIIRLGLL 259
Cdd:PTZ00345 164 NDVAREEFSEATIGCEDKDDALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTNTKSAIIRIGLE 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425  260 ETKKFVEHFYPSSVGHTYFESCGVADLITTCYGGRNRKVAEAFIKSD--KPLRVIEQELLKGQSAQGPPTAQDVYEMLEI 337
Cdd:PTZ00345 244 EMKLFGKIFFPNVMDETFFESCGLADLITTCLGGRNVRCAAEFAKRNgkKSWEEIEAELLNGQKLQGTVTLKEVYEVLES 323

                        330       340       350
                 ....*....|....*....|....*....|...
gi 17507425  338 NEISEKFPIFASVHKV-FTGHHGEqELYDSLRN 369
Cdd:PTZ00345 324 HDLKKEFPLFTVTYKIaFEGADPS-SLIDVLST 355
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 22-356 1.09e-79

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 247.26  E-value: 1.09e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425  22 KKIAIVGGGNWGSAIACVVGKtvKAQDevfqpiVSIWCRDsrkpgdlsPSIAETINSTHENPKYLPGRRIPDNVVATSSL 101
Cdd:COG0240   1 MKIAVLGAGSWGTALAKVLAR--NGHE------VTLWGRD--------PEVAEEINETRENPRYLPGVKLPENLRATSDL 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425 102 LEACQSAHILILVVPHQGIPQICDELRGKLQKGAHAISLTKGIssscENGEIKmqLISEDIERALG--VQCSVLMGANLA 179
Cdd:COG0240  65 EEALAGADLVLLAVPSQALREVLEQLAPLLPPGAPVVSATKGI----EPGTGL--LMSEVIAEELPgaLRIAVLSGPSFA 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425 180 GEVADGKFCEATIGCKSLKNGEELKKVFDTPNFRIRVTTDYEAVELCGALKNIVACAAGFADGLGWAYNVKSAIIRLGLL 259
Cdd:COG0240 139 EEVARGLPTAVVVASEDEEVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLA 218

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425 260 ETKKFVEHFYPSSvgHTYFESCGVADLITTCYG--GRNRKVAEAFIKSdKPLRVIEQELlkGQSAQGPPTAQDVYEMLEI 337
Cdd:COG0240 219 EMTRLGVALGARP--ETFMGLAGLGDLVLTCTSdlSRNRRFGLALGKG-KSLEEALAEM--GMVAEGVYTAKAVYELAEK 293

                       330
                ....*....|....*....
gi 17507425 338 NEIseKFPIFASVHKVFTG 356
Cdd:COG0240 294 LGV--EMPITEAVYAVLYE 310
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
22-353 3.79e-67

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 214.93  E-value: 3.79e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425   22 KKIAIVGGGNWGSAIACVVGKtvKAQDevfqpiVSIWCRDsrkpgdlsPSIAETINSTHENPKYLPGRRIPDNVVATSSL 101
Cdd:PRK00094   2 MKIAVLGAGSWGTALAIVLAR--NGHD------VTLWARD--------PEQAAEINADRENPRYLPGIKLPDNLRATTDL 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425  102 LEACQSAHILILVVPHQGIPQICDELRGKLQKGAHAISLTKGIssscENGeiKMQLISEDIERALGVQCS--VLMGANLA 179
Cdd:PRK00094  66 AEALADADLILVAVPSQALREVLKQLKPLLPPDAPIVWATKGI----EPG--TGKLLSEVLEEELPDLAPiaVLSGPSFA 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425  180 GEVADGKFCEATIGCKSLKNGEELKKVFDTPNFRIRVTTDYEAVELCGALKNIVACAAGFADGLGWAYNVKSAIIRLGLL 259
Cdd:PRK00094 140 KEVARGLPTAVVIASTDEELAERVQELFHSPYFRVYTNTDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLA 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425  260 ETKKFVEHFypssvG---HTYFESCGVADLITTCYG--GRNRKVAEAFIKSdKPLRVIEQELlkGQSAQGPPTAQDVYEM 334
Cdd:PRK00094 220 EITRLGVAL-----GanpETFLGLAGLGDLVLTCTSplSRNRRFGLALGQG-KSLEEALAEI--GMVAEGVRTAKAVYEL 291

                        330
                 ....*....|....*....
gi 17507425  335 LEINEIseKFPIFASVHKV 353
Cdd:PRK00094 292 AKKLGV--EMPITEAVYAV 308
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 223-356 1.16e-48

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 161.02  E-value: 1.16e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425   223 VELCGALKNIVACAAGFADGLGWAYNVKSAIIRLGLLETKKFVEHFYPSSvgHTYFESCGVADLITTCYGG--RNRKVAE 300
Cdd:pfam07479   5 VELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKALGAKP--ETFFGLAGLGDLIVTCTSGlsRNRRFGE 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 17507425   301 AFIKSdKPLRVIEQELlkGQSAQGPPTAQDVYEMLEINEIseKFPIFASVHKVFTG 356
Cdd:pfam07479  83 ALGKG-KSLEEAEKEL--GQVAEGVYTAKAVYELAKKLGV--EMPIFEAVYRILYE 133
NAD_Gly3P_dh_N pfam01210
NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent ...
 23-199 2.12e-48

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.


Pssm-ID: 395967 [Multi-domain]  Cd Length: 158  Bit Score: 160.82  E-value: 2.12e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425    23 KIAIVGGGNWGSAIACVVGKtvKAQDevfqpiVSIWCRDsrkpgdlsPSIAETINSTHENPKYLPGRRIPDNVVATSSLL 102
Cdd:pfam01210   1 KIAVLGAGSWGTALAKVLAD--NGHE------VRLWGRD--------EELIEEINTTHENVRYLPGIKLPENLKATTDLA 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425   103 EACQSAHILILVVPHQGIPQICDELRGKLQKGAHAISLTKGIssscENGEIKmqLISEDIERALGVQ--CSVLMGANLAG 180
Cdd:pfam01210  65 EALKGADIIVIVVPSQALREVLKQLKGLLKPDAILVSLSKGI----EPGTLK--LLSEVIEEELGIQppIAVLSGPSHAE 138

                         170
                  ....*....|....*....
gi 17507425   181 EVADGKFCEATIGCKSLKN 199
Cdd:pfam01210 139 EVAQGLPTATVIASKDEEA 157
PRK12439 PRK12439
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 23-369 1.24e-42

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 171500 [Multi-domain]  Cd Length: 341  Bit Score: 151.48  E-value: 1.24e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425   23 KIAIVGGGNWGSAIACVVGKTvkaqdevfQPIVsIWCRdsrkpgdlSPSIAETINSTHENPKYLP-GRRIPDNVVATSSL 101
Cdd:PRK12439   9 KVVVLGGGSWGTTVASICARR--------GPTL-QWVR--------SAETADDINDNHRNSRYLGnDVVLSDTLRATTDF 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425  102 LEACQSAHILILVVPHQGIPQICDELRGKLQKGAHAISLTKGIssscENGEIKMqlISEDIERAL-GVQCSVLMGANLAG 180
Cdd:PRK12439  72 AEAANCADVVVMGVPSHGFRGVLTELAKELRPWVPVVSLVKGL----EQGTNMR--MSQIIEEVLpGHPAGILAGPNIAR 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425  181 EVADGKFCEATIGCKSLKNGEELKKVFDTPNFRIRVTTDYEAVELCGALKNIVACAAGFADGLGWAYNVKSAIIRLGLLE 260
Cdd:PRK12439 146 EVAEGYAAAAVLAMPDQHLATRLSPLFRTRRFRVYTTDDVVGVEMAGALKNVFAIAVGMGYSLGIGENTRAMVIARALRE 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425  261 TKKFVEhfypsSVG---HTYFESCGVADLITTCYG--GRNRKVAEAfIKSDKPLRVIEQELlkGQSAQGPPTAQDVYEMl 335
Cdd:PRK12439 226 MTKLGV-----AMGgnpETFAGLAGMGDLIVTCTSqrSRNRHVGEQ-LGAGKPIDEIIASM--NQVAEGVKAASVVMEF- 296

                        330       340       350
                 ....*....|....*....|....*....|....
gi 17507425  336 eINEISEKFPIFASVHKVFTGHHGEQELYDSLRN 369
Cdd:PRK12439 297 -ADEYGLNMPIAREVDAVINHGSTVEQAYRGLIA 329
PRK14618 PRK14618
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 24-304 1.98e-35

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237770 [Multi-domain]  Cd Length: 328  Bit Score: 132.30  E-value: 1.98e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425   24 IAIVGGGNWGSAIACVVGKTVkaqdevfQPiVSIWCRdsrkpgdlSPSIAETINSTHENPKYLPGRRIPDNVVATSSLLE 103
Cdd:PRK14618   7 VAVLGAGAWGTALAVLAASKG-------VP-VRLWAR--------RPEFAAALAAERENREYLPGVALPAELYPTADPEE 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425  104 ACQSAHILILVVPHQGIPqicdELRGKLQKGAHAISLTKGISSscenGEIKMQLISEDIERALGVQCSVLMGANLAGEVA 183
Cdd:PRK14618  71 ALAGADFAVVAVPSKALR----ETLAGLPRALGYVSCAKGLAP----DGGRLSELARVLEFLTQARVAVLSGPNHAEEIA 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425  184 DGKFCEATIGCKSLKNGEELKKVFDTPNFRIRVTTDYEAVELCGALKNIVACAAGFADGLGWAYNVKSAIIRLGLLETKK 263
Cdd:PRK14618 143 RFLPAATVVASPEPGLARRVQAAFSGPSFRVYTSRDRVGVELGGALKNVIALAAGMVDGLKLGDNAKAALITRGLREMVR 222

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 17507425  264 FVEhfypSSVGH--TYFESCGVADLITTCYG--GRNRKVAEAFIK 304
Cdd:PRK14618 223 FGV----ALGAEeaTFYGLSGLGDLIATATSphSRNRAAGEAIVR 263
PRK14620 PRK14620
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 23-353 2.01e-26

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 173083 [Multi-domain]  Cd Length: 326  Bit Score: 107.61  E-value: 2.01e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425   23 KIAIVGGGNWGSAIACVVGKTvkaqdevfQPIVSIWCRDSRkpgdlspsIAETINSTHENPKYLPGRRIPDNVVATSSLL 102
Cdd:PRK14620   2 KISILGAGSFGTAIAIALSSK--------KISVNLWGRNHT--------TFESINTKRKNLKYLPTCHLPDNISVKSAID 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425  103 EA-CQSAHILILVVPHQGIPQICDELRGK-LQKGAHAISLTKGISSScengeiKMQLISEDIERALGVQ-CSVLMGANLA 179
Cdd:PRK14620  66 EVlSDNATCIILAVPTQQLRTICQQLQDChLKKNTPILICSKGIEKS------SLKFPSEIVNEILPNNpIAILSGPSFA 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425  180 GEVADGKFCEATIGCKSLKNGEELKKVFDTPNFRIRVTTDYEAVELCGALKNIVACAAGFADGLGWAYNVKSAIIRLGLL 259
Cdd:PRK14620 140 KEIAEKLPCSIVLAGQNETLGSSLISKLSNENLKIIYSQDIIGVQIGAALKNIIAIACGIVLGKNLGNNAHAAVITKGMN 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425  260 ETKKFVEHFYPSSVGHTYFESCGVADLITTCYGGRNRKVAEAFIKSDKplRVIEQELLKGQSA-QGPPTAQDVYEMLEin 338
Cdd:PRK14620 220 EIKTLYSAKNGSIDLNTLIGPSCLGDLILTCTTLHSRNMSFGFKIGNG--FNINQILSEGKSViEGFSTVKPLISLAK-- 295

                        330
                 ....*....|....*
gi 17507425  339 EISEKFPIFASVHKV 353
Cdd:PRK14620 296 KLNIELPICESIYNL 310
PRK14619 PRK14619
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 21-367 4.25e-24

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237771 [Multi-domain]  Cd Length: 308  Bit Score: 100.83  E-value: 4.25e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425   21 RKKIAIVGGGNWGSAIAcvvgKTVKAQDEVfqpiVSIWCRDSrkpgdlSPSIAETInsthenpkylpgrripdnvvatss 100
Cdd:PRK14619   4 PKTIAILGAGAWGSTLA----GLASANGHR----VRVWSRRS------GLSLAAVL------------------------ 45

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425  101 lleacQSAHILILVVPHQGIPQICDELRG-KLQKGAHAISLTKGISSscengeIKMQLISEDIERALGVQ-CSVLMGANL 178
Cdd:PRK14619  46 -----ADADVIVSAVSMKGVRPVAEQVQAlNLPPETIIVTATKGLDP------ETTRTPSQIWQAAFPNHpVVVLSGPNL 114

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425  179 AGEVADGKFCEATIGCKSLKNGEELKKVFDTPNFRIRVTTDYEAVELCGALKNIVACAAGFADGLGWAYNVKSAIIRLGL 258
Cdd:PRK14619 115 SKEIQQGLPAATVVASRDLAAAETVQQIFSSERFRVYTNSDPLGTELGGTLKNVIAIAAGVCDGLQLGTNAKAALVTRAL 194

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425  259 LETKKFVEHFypSSVGHTYFESCGVADLITTCYG--GRNRKVAEAFIKSdKPLRVIEQELlkGQSAQGPPTAQDVYEMLE 336
Cdd:PRK14619 195 PEMIRVGTHL--GAQTETFYGLSGLGDLLATCTSplSRNYQVGYGLAQG-KSLEQILAEL--EGTAEGVNTANVLVQLAQ 269

                        330       340       350
                 ....*....|....*....|....*....|.
gi 17507425  337 INEISekFPIFASVHKVFTGHHGEQELYDSL 367
Cdd:PRK14619 270 QQNIA--VPITEQVYRLLQGEITPQQALEEL 298
ProC COG0345
Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; ...
 22-172 7.54e-09

Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Pyrroline-5-carboxylate reductase is part of the Pathway/BioSystem: Proline biosynthesis


Pssm-ID: 440114 [Multi-domain]  Cd Length: 267  Bit Score: 55.84  E-value: 7.54e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507425  22 KKIAIVGGGNWGSAIAcvvgktvkaqdevfqpivSIWCRDSRKPGDL-----SPSIAETINSTHenpkylpgrripdNVV 96
Cdd:COG0345   3 MKIGFIGAGNMGSAII------------------KGLLKSGVPPEDIivsdrSPERLEALAERY-------------GVR 51

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17507425  97 ATSSLLEACQSAHILILVVPHQGIPQICDELRGKLQKGAHAISLTKGISsscengeikmqliSEDIERALGVQCSV 172
Cdd:COG0345  52 VTTDNAEAAAQADVVVLAVKPQDLAEVLEELAPLLDPDKLVISIAAGVT-------------LATLEEALGGGAPV 114
GPD_NAD_C_bact pfam20618
Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent ...
 281-350 6.27e-05

Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent glycerol-3-phosphate dehydrogenase (GPD) from bacteria and archaea. GPD catalyzes the reversible reduction of dihydroxyacetone phosphate to glycerol-3-phosphate.


Pssm-ID: 466767 [Multi-domain]  Cd Length: 66  Bit Score: 40.56  E-value: 6.27e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17507425   281 CGVADLITTCYGG--RNRKVAEAFIKsdkplRVIEQELLKGQSAQGPPTAQDVYEMLEINEiSEKFPIFASV 350
Cdd:pfam20618   1 AGLGDLVLTCTSDlsRNRTFGLLLGK-----GMTLAEAGNGQVAEGVRTAKAVAAILARAH-NVEMPILEAV 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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