NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17536001|ref|NP_494344|]
View 

WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
54-346 5.77e-28

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 5.77e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001  54 GHVDTVNNLTVIRAG-MILSGGKDGRAVLTNTDSGEI------HNMWSNSCEINKicyrnfiAKHSLIAAGRNGTLTHWm 126
Cdd:COG2319 118 GHTGAVRSVAFSPDGkTLASGSADGTVRLWDLATGKLlrtltgHSGAVTSVAFSP-------DGKLLASGSDDGTVRLW- 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001 127 fNHEPGDLPNvVFDGHKFGVTGV-VSINENQFMSGSRDCSVKIWDLESAKCVRTQTINRNLVTHMAY--NGNLVAQTSED 203
Cdd:COG2319 190 -DLATGKLLR-TLTGHTGAVRSVaFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFspDGRLLASGSAD 267

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001 204 KSVRLWDPRNASVVTEFPRKRHIQMFCEF--DGaNRFFSCSngfnNDGcEITSYDVRNPRQSREARGHEGNVTSLSIVQM 281
Cdd:COG2319 268 GTVRLWDLATGELLRTLTGHSGGVNSVAFspDG-KLLASGS----DDG-TVRLWDLATGKLLRTLTGHTGAVRSVAFSPD 341

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17536001 282 DQTkrlLASVSADRQIRLWKIeeDGQAVLKPIWNEDVPLEAdnlqVCSYPDGHIIVSGGKGRLIH 346
Cdd:COG2319 342 GKT---LASGSDDGTVRLWDL--ATGELLRTLTGHTGAVTS----VAFSPDGRTLASGSADGTVR 397
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
54-346 5.77e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 5.77e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001  54 GHVDTVNNLTVIRAG-MILSGGKDGRAVLTNTDSGEI------HNMWSNSCEINKicyrnfiAKHSLIAAGRNGTLTHWm 126
Cdd:COG2319 118 GHTGAVRSVAFSPDGkTLASGSADGTVRLWDLATGKLlrtltgHSGAVTSVAFSP-------DGKLLASGSDDGTVRLW- 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001 127 fNHEPGDLPNvVFDGHKFGVTGV-VSINENQFMSGSRDCSVKIWDLESAKCVRTQTINRNLVTHMAY--NGNLVAQTSED 203
Cdd:COG2319 190 -DLATGKLLR-TLTGHTGAVRSVaFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFspDGRLLASGSAD 267

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001 204 KSVRLWDPRNASVVTEFPRKRHIQMFCEF--DGaNRFFSCSngfnNDGcEITSYDVRNPRQSREARGHEGNVTSLSIVQM 281
Cdd:COG2319 268 GTVRLWDLATGELLRTLTGHSGGVNSVAFspDG-KLLASGS----DDG-TVRLWDLATGKLLRTLTGHTGAVRSVAFSPD 341

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17536001 282 DQTkrlLASVSADRQIRLWKIeeDGQAVLKPIWNEDVPLEAdnlqVCSYPDGHIIVSGGKGRLIH 346
Cdd:COG2319 342 GKT---LASGSDDGTVRLWDL--ATGELLRTLTGHTGAVTS----VAFSPDGRTLASGSADGTVR 397
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-301 2.44e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 106.65  E-value: 2.44e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001  54 GHVDTVNNLTVIRAGM-ILSGGKDGRAVLTNTDSGEIHNMWSN-SCEINKICyrnFIAKHSLIAA-GRNGTLTHWmfnhe 130
Cdd:cd00200  49 GHTGPVRDVAASADGTyLASGSSDKTIRLWDLETGECVRTLTGhTSYVSSVA---FSPDGRILSSsSRDKTIKVW----- 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001 131 pgDLPN----VVFDGHKFGVTGVVSINENQFM-SGSRDCSVKIWDLESAKCVRTQTINRNLVTHMAY--NGNLVAQTSED 203
Cdd:cd00200 121 --DVETgkclTTLRGHTDWVNSVAFSPDGTFVaSSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFspDGEKLLSSSSD 198

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001 204 KSVRLWDPRNASVVTEFPRKRHIQMFCEFDGANRFFSCSNgfnnDGCEITSYDVRNPRQSREARGHEGNVTSLSivqMDQ 283
Cdd:cd00200 199 GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGS----EDGTIRVWDLRTGECVQTLSGHTNSVTSLA---WSP 271

                       250
                ....*....|....*...
gi 17536001 284 TKRLLASVSADRQIRLWK 301
Cdd:cd00200 272 DGKRLASGSADGTIRIWD 289
PTZ00421 PTZ00421
coronin; Provisional
 135-218 2.83e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.04  E-value: 2.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001  135 PNVVFDGHKFGVtGVVSIN---ENQFMSGSRDCSVKIWDLESAKCVRTQTINRNLVTHMAYN--GNLVAQTSEDKSVRLW 209
Cdd:PTZ00421 117 PIVHLQGHTKKV-GIVSFHpsaMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNldGSLLCTTSKDKKLNII 195


                 ....*....
gi 17536001  210 DPRNASVVT 218
Cdd:PTZ00421 196 DPRDGTIVS 204
WD40 pfam00400
WD domain, G-beta repeat;
138-170 2.54e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.54e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 17536001   138 VFDGHKFGVTGV-VSINENQFMSGSRDCSVKIWD 170
Cdd:pfam00400   6 TLEGHTGSVTSLaFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 138-170 3.50e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 3.50e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 17536001    138 VFDGHKFGVTGV-VSINENQFMSGSRDCSVKIWD 170
Cdd:smart00320   7 TLKGHTGPVTSVaFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
54-346 5.77e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 5.77e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001  54 GHVDTVNNLTVIRAG-MILSGGKDGRAVLTNTDSGEI------HNMWSNSCEINKicyrnfiAKHSLIAAGRNGTLTHWm 126
Cdd:COG2319 118 GHTGAVRSVAFSPDGkTLASGSADGTVRLWDLATGKLlrtltgHSGAVTSVAFSP-------DGKLLASGSDDGTVRLW- 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001 127 fNHEPGDLPNvVFDGHKFGVTGV-VSINENQFMSGSRDCSVKIWDLESAKCVRTQTINRNLVTHMAY--NGNLVAQTSED 203
Cdd:COG2319 190 -DLATGKLLR-TLTGHTGAVRSVaFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFspDGRLLASGSAD 267

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001 204 KSVRLWDPRNASVVTEFPRKRHIQMFCEF--DGaNRFFSCSngfnNDGcEITSYDVRNPRQSREARGHEGNVTSLSIVQM 281
Cdd:COG2319 268 GTVRLWDLATGELLRTLTGHSGGVNSVAFspDG-KLLASGS----DDG-TVRLWDLATGKLLRTLTGHTGAVRSVAFSPD 341

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17536001 282 DQTkrlLASVSADRQIRLWKIeeDGQAVLKPIWNEDVPLEAdnlqVCSYPDGHIIVSGGKGRLIH 346
Cdd:COG2319 342 GKT---LASGSDDGTVRLWDL--ATGELLRTLTGHTGAVTS----VAFSPDGRTLASGSADGTVR 397
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-301 2.44e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 106.65  E-value: 2.44e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001  54 GHVDTVNNLTVIRAGM-ILSGGKDGRAVLTNTDSGEIHNMWSN-SCEINKICyrnFIAKHSLIAA-GRNGTLTHWmfnhe 130
Cdd:cd00200  49 GHTGPVRDVAASADGTyLASGSSDKTIRLWDLETGECVRTLTGhTSYVSSVA---FSPDGRILSSsSRDKTIKVW----- 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001 131 pgDLPN----VVFDGHKFGVTGVVSINENQFM-SGSRDCSVKIWDLESAKCVRTQTINRNLVTHMAY--NGNLVAQTSED 203
Cdd:cd00200 121 --DVETgkclTTLRGHTDWVNSVAFSPDGTFVaSSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFspDGEKLLSSSSD 198

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001 204 KSVRLWDPRNASVVTEFPRKRHIQMFCEFDGANRFFSCSNgfnnDGCEITSYDVRNPRQSREARGHEGNVTSLSivqMDQ 283
Cdd:cd00200 199 GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGS----EDGTIRVWDLRTGECVQTLSGHTNSVTSLA---WSP 271

                       250
                ....*....|....*...
gi 17536001 284 TKRLLASVSADRQIRLWK 301
Cdd:cd00200 272 DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
54-303 2.20e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.15  E-value: 2.20e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001  54 GHVDTVNNLTVIRAG-MILSGGKDGRAVLTNTDSGE-IHNMWSNSCEINKICY---RNFIAkhsliAAGRNGTLTHWmfN 128
Cdd:COG2319 160 GHSGAVTSVAFSPDGkLLASGSDDGTVRLWDLATGKlLRTLTGHTGAVRSVAFspdGKLLA-----SGSADGTVRLW--D 232

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001 129 HEPGDLPnVVFDGHKFGVTGVV-SINENQFMSGSRDCSVKIWDLESAKCVRTQTINRNLVTHMAY--NGNLVAQTSEDKS 205
Cdd:COG2319 233 LATGKLL-RTLTGHSGSVRSVAfSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLLASGSDDGT 311

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001 206 VRLWDPRNASVVTEFPRKRHIQMFCEF--DGaNRFFSCSngfnNDGcEITSYDVRNPRQSREARGHEGNVTSLSIvqmDQ 283
Cdd:COG2319 312 VRLWDLATGKLLRTLTGHTGAVRSVAFspDG-KTLASGS----DDG-TVRLWDLATGELLRTLTGHTGAVTSVAF---SP 382

                       250       260
                ....*....|....*....|
gi 17536001 284 TKRLLASVSADRQIRLWKIE 303
Cdd:COG2319 383 DGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-340 7.99e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 99.72  E-value: 7.99e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001  54 GHVDTVNNLTVIRAG-MILSGGKDGRAVLTNTDSGEI------HNMWSNSCeinkICYRNFiakHSLIAAGRNGTLTHWm 126
Cdd:cd00200   7 GHTGGVTCVAFSPDGkLLATGSGDGTIKVWDLETGELlrtlkgHTGPVRDV----AASADG---TYLASGSSDKTIRLW- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001 127 fnhepgDLPN----VVFDGHKFGVTGVVSINENQFM-SGSRDCSVKIWDLESAKCVRTQTINRNLVTHMAYNGN--LVAQ 199
Cdd:cd00200  79 ------DLETgecvRTLTGHTSYVSSVAFSPDGRILsSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDgtFVAS 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001 200 TSEDKSVRLWDPRNASVVTEFP-RKRHIQMFCEFDGANRFFSCSNgfnnDGCeITSYDVRNPRQSREARGHEGNVTSLSI 278
Cdd:cd00200 153 SSQDGTIKLWDLRTGKCVATLTgHTGEVNSVAFSPDGEKLLSSSS----DGT-IKLWDLSTGKCLGTLRGHENGVNSVAF 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17536001 279 vqmDQTKRLLASVSADRQIRLWKIE-EDGQAVLK----PIWnedvpleadnlQVCSYPDGHIIVSGG 340
Cdd:cd00200 228 ---SPDGYLLASGSEDGTIRVWDLRtGECVQTLSghtnSVT-----------SLAWSPDGKRLASGS 280
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 113-345 4.54e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.71  E-value: 4.54e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001 113 LIAAGRNGTLTHWmfNHEPGDLPNVvFDGHKFGVTGVVSINENQFM-SGSRDCSVKIWDLESAKCVRTQTINRNLVTHMA 191
Cdd:cd00200  24 LATGSGDGTIKVW--DLETGELLRT-LKGHTGPVRDVAASADGTYLaSGSSDKTIRLWDLETGECVRTLTGHTSYVSSVA 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001 192 Y--NGNLVAQTSEDKSVRLWDPRNASVVTEFPRKRHIQMFCEFDGANRF-FSCSNgfnnDGCeITSYDVRNPRQSREARG 268
Cdd:cd00200 101 FspDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFvASSSQ----DGT-IKLWDLRTGKCVATLTG 175

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17536001 269 HEGNVTSLSIvqmDQTKRLLASVSADRQIRLWKIeeDGQAVLKPIWNEDVPLEAdnlqVCSYPDGHIIVSGGKGRLI 345
Cdd:cd00200 176 HTGEVNSVAF---SPDGEKLLSSSSDGTIKLWDL--STGKCLGTLRGHENGVNS----VAFSPDGYLLASGSEDGTI 243
WD40 COG2319
WD40 repeat [General function prediction only];
113-346 6.57e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.13  E-value: 6.57e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001 113 LIAAGRNGTLTHWMFNhepGDLPNVVFDGHKFGVTGV-VSINENQFMSGSRDCSVKIWDLESAKCVRTQTINRNLVTHMA 191
Cdd:COG2319  93 LASASADGTVRLWDLA---TGLLLRTLTGHTGAVRSVaFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVA 169

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001 192 Y--NGNLVAQTSEDKSVRLWDPRNASVVTEFPRKRHIQMFCEF--DGaNRFFSCSngfnNDGcEITSYDVRNPRQSREAR 267
Cdd:COG2319 170 FspDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDG-KLLASGS----ADG-TVRLWDLATGKLLRTLT 243

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17536001 268 GHEGNVTSLSIvqmDQTKRLLASVSADRQIRLWKIEEDGQAVLKPIWNEDVpleadnLQVCSYPDGHIIVSGGKGRLIH 346
Cdd:COG2319 244 GHSGSVRSVAF---SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGV------NSVAFSPDGKLLASGSDDGTVR 313
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 138-340 2.23e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.78  E-value: 2.23e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001 138 VFDGHKFGVTGVVSINENQFM-SGSRDCSVKIWDLESAKCVRTQTINRNLVTHMAY--NGNLVAQTSEDKSVRLWDPRNA 214
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLaTGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETG 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001 215 SVVTEFprKRHIQMF--CEFDGANRFFSCSNGfnnDGCeITSYDVRNPRQSREARGHEGNVTSLSIvqmDQTKRLLASVS 292
Cdd:cd00200  84 ECVRTL--TGHTSYVssVAFSPDGRILSSSSR---DKT-IKVWDVETGKCLTTLRGHTDWVNSVAF---SPDGTFVASSS 154

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 17536001 293 ADRQIRLWKIEEdgqavLKPIWNedvpLEADNLQVCS---YPDGHIIVSGG 340
Cdd:cd00200 155 QDGTIKLWDLRT-----GKCVAT----LTGHTGEVNSvafSPDGEKLLSSS 196
WD40 COG2319
WD40 repeat [General function prediction only];
138-346 4.45e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.04  E-value: 4.45e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001 138 VFDGHKFGVTGVV-SINENQFMSGSRDCSVKIWDLESAKCVRTQTINRNLVTHMAY--NGNLVAQTSEDKSVRLWDPRNA 214
Cdd:COG2319  73 TLLGHTAAVLSVAfSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFspDGKTLASGSADGTVRLWDLATG 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001 215 SVVTEFPRKRHIQMFCEF--DGaNRFFSCSngfnNDGcEITSYDVRNPRQSREARGHEGNVTSLSIvqmDQTKRLLASVS 292
Cdd:COG2319 153 KLLRTLTGHSGAVTSVAFspDG-KLLASGS----DDG-TVRLWDLATGKLLRTLTGHTGAVRSVAF---SPDGKLLASGS 223

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 17536001 293 ADRQIRLWKIeEDGQAVLkpiwnedvPLEADNLQVCSY---PDGHIIVSGGKGRLIH 346
Cdd:COG2319 224 ADGTVRLWDL-ATGKLLR--------TLTGHSGSVRSVafsPDGRLLASGSADGTVR 271
WD40 COG2319
WD40 repeat [General function prediction only];
54-213 8.66e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.03  E-value: 8.66e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001  54 GHVDTVNNLTVIRAG-MILSGGKDGRAVLTNTDSGEI------HNMWSNSCEI---NKIcyrnfiakhsLIAAGRNGTLT 123
Cdd:COG2319 244 GHSGSVRSVAFSPDGrLLASGSADGTVRLWDLATGELlrtltgHSGGVNSVAFspdGKL----------LASGSDDGTVR 313

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001 124 HWmfNHEPGDLPnVVFDGHKFGVTGVV-SINENQFMSGSRDCSVKIWDLESAKCVRTQTINRNLVTHMAY--NGNLVAQT 200
Cdd:COG2319 314 LW--DLATGKLL-RTLTGHTGAVRSVAfSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFspDGRTLASG 390

                       170
                ....*....|...
gi 17536001 201 SEDKSVRLWDPRN 213
Cdd:COG2319 391 SADGTVRLWDLAT 403
PTZ00421 PTZ00421
coronin; Provisional
 135-218 2.83e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.04  E-value: 2.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001  135 PNVVFDGHKFGVtGVVSIN---ENQFMSGSRDCSVKIWDLESAKCVRTQTINRNLVTHMAYN--GNLVAQTSEDKSVRLW 209
Cdd:PTZ00421 117 PIVHLQGHTKKV-GIVSFHpsaMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNldGSLLCTTSKDKKLNII 195


                 ....*....
gi 17536001  210 DPRNASVVT 218
Cdd:PTZ00421 196 DPRDGTIVS 204
WD40 pfam00400
WD domain, G-beta repeat;
138-170 2.54e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.54e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 17536001   138 VFDGHKFGVTGV-VSINENQFMSGSRDCSVKIWD 170
Cdd:pfam00400   6 TLEGHTGSVTSLaFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 138-170 3.50e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 3.50e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 17536001    138 VFDGHKFGVTGV-VSINENQFMSGSRDCSVKIWD 170
Cdd:smart00320   7 TLKGHTGPVTSVaFSPDGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 103-220 2.65e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.93  E-value: 2.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536001  103 CYRNFIAKHSliaagRNGTLTHWMFNHEPGDL-----PNVVFDGHKFGVTgVVSINE-NQFM--SGSRDCSVKIWDLESA 174
Cdd:PTZ00420  85 CFSEILASGS-----EDLTIRVWEIPHNDESVkeikdPQCILKGHKKKIS-IIDWNPmNYYImcSSGFDSFVNIWDIENE 158

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 17536001  175 KcvRTQTINR-NLVTHMAYN--GNLVAQTSEDKSVRLWDPRNASVVTEF 220
Cdd:PTZ00420 159 K--RAFQINMpKKLSSLKWNikGNLLSGTCVGKHMHIIDPRKQEIASSF 205
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 267-301 3.15e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 3.15e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 17536001    267 RGHEGNVTSLSIvqmDQTKRLLASVSADRQIRLWK 301
Cdd:smart00320   9 KGHTGPVTSVAF---SPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH