|
Name |
Accession |
Description |
Interval |
E-value |
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
46-1301 |
0e+00 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 809.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 46 PTWCDADMSLQQIKRGKAVGNTVALTARAFFQLWLFRIGCFVQRWAWSTIFISLFLYCLCLGGLRHVTIETDLVKLWVSE 125
Cdd:TIGR00918 13 PSYCDAAFALEQIDKGKATGRRAPLWLRAKFQRLLFTLGCYIQKHCGKVLFVGLLVFSAFAVGLRAANIETNVEQLWVEV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 126 GGRLNEEMGYLGQvkferesghlvhkvKRAVEQTTEPpapavkaevrrgpelpkenglgggfQVVIQTPSFDGQNILSKE 205
Cdd:TIGR00918 93 GGRVSQELAYTRQ--------------KIGEEAMFTP-------------------------QLLIQTPHQEGANVLTPE 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 206 ALQQHTKLMEEISTYEVKMFNETWTLSDICFKPPGPSFNsgplAGIMSKLLDKIIPCIWITPIDCYWDGAKPLGPnppln 285
Cdd:TIGR00918 134 ALLQHLDSALKASRVHVYLYNRQWGLEHLCYKSGEPSTE----GGYIEQILEKLIPCLIITPLDCFWEGAKLQGG----- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 286 lgpevASFVSSLPPgnVTWKNLNPTSVIKEVGTL-FDLGPIGNFFERAGIDGAYLDRPCIDPLEEECPKSAPNYfdrcha 364
Cdd:TIGR00918 205 -----TAYLPGKPP--LQWTNLDPASFLEELKQKmSQVESWEEMLKKAAVGQGYMERPCLNPADPDCPDTAPNK------ 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 365 ltkfnewnmakamseqvtlerkiipkddgksdiaetilndifgkkrrkrqadtttkkpatkkdedyyeyeddadylagia 444
Cdd:TIGR00918 --------------------------------------------------------------------------------
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 445 NSTIAkknpekeakdllcleygssllkwmqenperlgefltkeempdyPNYGDVMTGGCKGFGKKIMEWPEDLIIGGIQR 524
Cdd:TIGR00918 272 NSTQP-------------------------------------------PDVAAVLSGGCYGLSAKYMHWQEELIVGGTKR 308
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 525 D-NGKLVSAEALQSVFLVSGAYDVFARIKNDKTDSHPGLDRHHfqpwmAGEIISTWQRNFTKRLysHELNRER--RQFHP 601
Cdd:TIGR00918 309 NrSGKLLSAQALQSMFQLMTPKQMYEHFKGYYKVHHIGWNEEK-----AAAVLEAWQRNFSEEV--QQSLPKNssQKILV 381
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 602 LASTSIADMLEEFSQFNYIIIVIGYILMVIYAAFTQGRfqgwWLAVQSNVALAICGVILVTISSICGLGFATHLGINFNA 681
Cdd:TIGR00918 382 FSSTTLDDILKKFSDVSAIRIVSGYLLMLAYACLTMLR----WDCAKSQGSVGLAGVLLVALSVAAGLGLCALLGISFNA 457
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 682 ATTQVVPFLSLGLGIDDMFLLLHNYDEII-NICNKNEIGVLLKETGMSVMLTSINNILAFISGYVLPIPALRSFCSQTAI 760
Cdd:TIGR00918 458 ATTQVLPFLALGVGVDDVFLLAHAFSETGqNIPFEERTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAI 537
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 761 LLAFNLIFLMFIFPAMIGIDLRRQRKGKRDLAYCS---------RGNPQ-MATSQSVPSNVS---------NNTQMSSRA 821
Cdd:TIGR00918 538 VVVFNFAAVLLVFPAILSLDLRRREDRRLDIFCCFfspcsarviQIEPQaYADGSAPPVYSShmqstvqlrTEYDPGTQH 617
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 822 -------------------------------ELAGYEKQADEYKRHEPW--YTVGGFLNKIYIPALKNNVVKACVLIGTT 868
Cdd:TIGR00918 618 yyttneprshlsvqpsdplscqspdiagstrDLLSQFEDSKAACLSLPCarWTLATFAEKHYAPFLLQSWAKVVVIFLFL 697
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 869 TAVVFGLYGMYTSTLGLELADVLPEHTPPAAFLRAREQYFSFYPMFAVLRGDkLDIPNQQQLIEEYRAQLGSSKFMIKAE 948
Cdd:TIGR00918 698 ALLGLSLYGTTRVQDGLDLTDIVPRDTNEHDFLDAQFRYFSFYNMYAVTQGN-FDYPTQQQLLYDLHQSFSSVKYVLKED 776
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 949 -GKLQPYWMSMLRVWLQSLDMALEKDLAAGKfdLTNGNpiKVNGekpSPESMIAARLVCSFGTNYNC--DGRLGKMKMVE 1025
Cdd:TIGR00918 777 nGQLPRMWLHYFRDWLQGLQKAFDEDWRDGR--ITKEN--YRNG---SDDAVLAYKLLVQTGHRDKPvdKEQLTTQRLVN 849
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 1026 NE-VINPEGFYNYLTGWFNVDNMMYYVSQASFYPTPPGW-----EYNEKLAKVvPAAEPLLYSQMPFYQNDLIDTPAIVK 1099
Cdd:TIGR00918 850 ADgIINPNAFYIYLSAWVSNDPVAYAASQANIYPHPPEWlhdknDYDPENLRI-PAAEPLEYAQFPFYLNGLRETSQFVE 928
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 1100 MIEEIRATCEEYSERGLSNHPSGIAFTFWEQYLTLRWNLFQAICIIALAVFCVISILMFNPWAATLIMCIVVITTIELGG 1179
Cdd:TIGR00918 929 AIEHVRAICNNYEGFGLPSYPSGYPFLFWEQYMGLRHWLLLSISVVLACTFLVCALLLLNPWTAGLIVLVLALMTVELFG 1008
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 1180 FMGLMGIKMNPISAVTLICAVGIGVEFTAHVELAFLTALGTIDQRLESCLQHMFVPVYHGAISTFLGVVMLVFSEFDFVV 1259
Cdd:TIGR00918 1009 MMGLLGIKLSAIPVVILIASVGIGVEFTVHIALGFLTAIGDRNRRAVLALEHMFAPVLDGALSTLLGVLMLAGSEFDFIV 1088
|
1290 1300 1310 1320
....*....|....*....|....*....|....*....|..
gi 71997494 1260 TYFFYTMTLLVALGVFNGLCVLPVILTLVGPKPELTPTDGSS 1301
Cdd:TIGR00918 1089 RYFFAVLAVLTCLGVLNGLVLLPVLLSMFGPEPEVSPAEGRS 1130
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
598-1288 |
6.77e-56 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 209.52 E-value: 6.77e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 598 QFHPLASTSIADMLEEFSQFNYIIIVIGYILMVIYAAFTQGRFQ----GWwlaVQSNVALAICGVILVTISSICGLGFAT 673
Cdd:pfam02460 195 QFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVSVTLSsytiDW---VRSKPILAALGLLSPVMAIVSSFGLLF 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 674 HLGINFNAATTqVVPFLSLGLGIDDMFLLLHNYDEIINICN-KNEIGVLLKETGMSVMLTSINNILAFISGYVLPIPALR 752
Cdd:pfam02460 272 WMGFPFNSIVC-VTPFLVLAIGVDDMFLMVAAWQRTTATLSvKKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQ 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 753 SFCSQTAILLAFNLIFLMFIFPAMIGIDLRRQRKGKRDLAYCSRGNPQMATSQ-SVPSNVSNNTQMSSRaelagyekqad 831
Cdd:pfam02460 351 LFCAYTAVAIFFDFIYQITFFAAIMAICAKPEAEGRHCLFVWATSSPQRIDSEgSEPDKSHNIEQLKSR----------- 419
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 832 eykrhepwytvggFLNKIYIPALKNNVVKACVLIgtTTAVVFGL--YGMYTSTLGLELADVLPEHTPPAAFLRAREQYFS 909
Cdd:pfam02460 420 -------------FFLDIYCPFLLNPSVRVCMLV--LFVVYIAIaiYGCVNIKEGLEPDKLVLEDSPLVEYLSLREKHFW 484
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 910 FY--PM-FAVLRGDKLDIPNQQQLIEEYRAQLGSSKFMIKAEGKLqpYWMsmlrvwlqsldmalekdlaagkFDLTNgnp 986
Cdd:pfam02460 485 PEglQIqVAVNNPPNLTIPESRDRMNEMVDEFENTPYSLGPNSTL--FWL----------------------REYEN--- 537
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 987 ikvngekpspesmiaarlvcsfgtnyncdgRLGKMKMVENEVINPEGFYNYLTGWFnvdnmmyyvsQASFYPTppgWEYN 1066
Cdd:pfam02460 538 ------------------------------FLSTLNMEEEEDEEKEWSYGNLPSFL----------KAPGNSH---WAGD 574
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 1067 EKLAKVVPAAEPLLYSQMPFyqnDLIDTPAIVKMIEEIRATCEEYSERGLSN-HPSgiaFTFWEQYLTLRWNLFQAICII 1145
Cdd:pfam02460 575 LVWDDNTTMVTKFRFTLAGK---GLSTWNDRTRALQEWRSIADQYPEFNVTVfDED---APFADQYLTILPSTIQNIVIT 648
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 1146 ALAVFCVISILMFNPWAATLIMCivVITTIELG--GFMGLMGIKMNPISAVTLICAVGIGVEFTAHVELAFLTALG-TID 1222
Cdd:pfam02460 649 LICMFIVCFLFIPNPPCVFVITL--AIASIDIGvfGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFVRSRGdTPA 726
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 71997494 1223 QRLESCLQHMFVPVYHGAISTFLGVVMLVFSEFDFVVTyFFYTMTLLVALGVFNGLCVLPVILTLV 1288
Cdd:pfam02460 727 ERVVDALEALGWPVFQGGLSTILGVLVLLFVPSYMVVV-FFKTVFLVVAIGLLHGLFILPIILSLF 791
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
579-1289 |
1.32e-46 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 183.57 E-value: 1.32e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 579 WQRNFTKRLYSHELNRERRQFHPLASTSIADMLEEFSQFNYIIIVIGYILMVIYAAFTQG---RFQGwwLAVQSNVALAI 655
Cdd:TIGR00917 534 WEKAFIQLAKDELLPMVQATISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTLGdspRLKS--LYVTSKVLLGL 611
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 656 CGVILVTISSICGLGFATHLGINFNAATTQVVPFLSLGLGIDDMFLLLHNY------------DEIINICNKNEIGVLLK 723
Cdd:TIGR00917 612 SGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYfyleyfyrqvgvDNEQELTLERRLSRALM 691
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 724 ETGMSVMLTSINNILAFISGYVLPIPALRSFcSQTAILLAFnLIFLMFI--FPAMIGIDLRRQRKGKRDLAYCSRGnpqm 801
Cdd:TIGR00917 692 EVGPSITLASLSEILAFALGALIKMPAVRVF-SMFAVLAVF-LDFLLQItaFVALLVLDFKRTEDKRVDCFPCIKT---- 765
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 802 atsqsvpSNVSNNTQMSSRaelagyekqadeyKRHEPWYTVggFLNKIYIPALKNNVVKACVLIGTTTAVVFGLYGMYTS 881
Cdd:TIGR00917 766 -------SKSSISAEKGSG-------------QRKAGLLTR--YFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRV 823
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 882 TLGLELADVLPEHTPPAAFLRAREQYFSFYPMFA-VLRGDKLDIPNQQQliEEYRAQLGSSKFMIKAEGKLQPY------ 954
Cdd:TIGR00917 824 EIGLDQQIVLPQDSYLQIYFASLTPLLEVGPPFYiVIKGDYNYTDFESQ--NKLCTMGGCDKDSIVNVFNNLSYiakpas 901
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 955 -WMSMLRVWLQSLDMALEKDLAAGKFdltngnpikVNGEKPSpesmiAARlvCSFGTNyNCDGRlgkmkmvenevINPEG 1033
Cdd:TIGR00917 902 sWLDDYLVWLSPQASCCCRKFTNGTF---------CNGPDPQ-----CFR--CADLSS-DAQGR-----------PSTTQ 953
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 1034 FYNYLTGWFNVDN--------MMYYVSQASFyptppgweynEKLAKVVPAAEPLLYSQMPFYQNDLIDTpaiVKMIEEIR 1105
Cdd:TIGR00917 954 FKEKLPWFLNALPsadcakggHAAYSSAVDL----------QGYATIIQASSFRTYHTPLNTQVDFINA---MRAAQEFA 1020
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 1106 ATCEEYSErgLSNHPSGIAFTFWEQYLTLRWNLFQAICIIALAVFCVISILM-FNPWAATLIMCIVVITTIELGGFMGLM 1184
Cdd:TIGR00917 1021 AKVSRSSK--MEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLqLNALSVVNLIMSVGMAVVFCVGIMHLW 1098
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 1185 GIKMNPISAVTLICAVGIGVEFTAHVELAFLTAL-GTIDQRLESCLQHMFVPVYHG-AISTFLGVVMLVFSEFDFVVTYF 1262
Cdd:TIGR00917 1099 SISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKhFSRNHRAKEALGGMGSSVFSGiTLTKLVGVVVLGFSRSEIFVVYY 1178
|
730 740
....*....|....*....|....*..
gi 71997494 1263 FYTMTLLVALGVFNGLCVLPVILTLVG 1289
Cdd:TIGR00917 1179 FRMYLALVLLGFLHGLVFLPVLLSVLG 1205
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
646-797 |
8.92e-34 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 127.31 E-value: 8.92e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 646 AVQSNVALAICGVILVTISSICGLGFATHLGINFNAATTQVVPFLSLGLGIDDMFLLLHNYDEI-INICNKNEIGVLLKE 724
Cdd:pfam12349 1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTpRSLDVSERIAEALGE 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 71997494 725 TGMSVMLTSINNILAFISGYVLPIPALRSFCSQTAILLAFNLIFLMFIFPAMIGIDLRRQRKGKRDLAYCSRG 797
Cdd:pfam12349 81 VGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCIRV 153
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
620-1291 |
2.15e-25 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 113.80 E-value: 2.15e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 620 IIIVIGYILMVIYAAFTQGRFQGWWLAVqsnvalaicGVILVTIssICGLGFATHLGINFNAATTqVVPFLSLGLGIDD- 698
Cdd:COG1033 222 IFFPLALLLILLLLFLFFRSLRGVLLPL---------LVVLLAV--IWTLGLMGLLGIPLSPLTI-LVPPLLLAIGIDYg 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 699 MFLLLHNYDEIINICNKNE-IGVLLKETGMSVMLTSINNILAFISGYVLPIPALRSFCSQTAILLAFNLIFLMFIFPAMI 777
Cdd:COG1033 290 IHLLNRYREERRKGLDKREaLREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPALL 369
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 778 GIdLRRQRKGKRDlaycsrgnpqmatsqsvpsnvsnntqmssraelagyekqadeyKRHEPwyTVGGFLNKIYIPALKNN 857
Cdd:COG1033 370 SL-LPRPKPKTRR-------------------------------------------LKKPP--ELGRLLAKLARFVLRRP 403
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 858 VVkacVLIGTTTAVVFGLYGMYTSTLGLELADVLPEHTPPAAFLRAREQYF-SFYPMFAVLRGDKLDIpnqqqlIEEYRA 936
Cdd:COG1033 404 KV---ILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSPIRQDLDFIEENFgGSDPLEVVVDTGEPDG------LKDPEV 474
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 937 qlgsskfmikaegklqpywmsmlrvwLQSLDmALEKDLAAgkfdltNGNPIKVNgekpSPESMIaarlvcsfgtnyncdg 1016
Cdd:COG1033 475 --------------------------LKEID-RLQDYLES------LPEVGKVL----SLADLV---------------- 501
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 1017 rlgkmkmvenEVINpEGFYNYLTGWFNVDNMMYYVSQASFYPTPPGWEyneklakvvpAAEPLL---YSQMP--FYQNDl 1091
Cdd:COG1033 502 ----------KELN-QALNEGDPKYYALPESRELLAQLLLLLSSPPGD----------DLSRFVdedYSAARvtVRLKD- 559
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 1092 IDTPAIVKMIEEIRATCEEY-SERGLSNHPSGIAFTFWEQYLTLRWNLFQAIcIIALAVFCVISILMFNPWAATLIMCIV 1170
Cdd:COG1033 560 LDSEEIKALVEEVRAFLAENfPPDGVEVTLTGSAVLFAAINESVIESQIRSL-LLALLLIFLLLLLAFRSLRLGLISLIP 638
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 1171 VITTIEL-GGFMGLMGIKMNPISAVTLICAVGIGVEFTAHVELAFLTAL---GTIDQRLESCLQHMFVPVYHGAISTFLG 1246
Cdd:COG1033 639 NLLPILLtFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREERrkgGDLEEAIRRALRTTGKAILFTSLTLAAG 718
|
650 660 670 680
....*....|....*....|....*....|....*....|....*....
gi 71997494 1247 VVMLVFSEFDFVVtyffyTMTLLVALGVFNG----LCVLPVILTLVGPK 1291
Cdd:COG1033 719 FGVLLFSSFPPLA-----DFGLLLALGLLVAllaaLLLLPALLLLLDPR 762
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
1083-1293 |
7.76e-14 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 76.44 E-value: 7.76e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 1083 QMPFYQNDLIDTPAIVKMIEEIRATCEEYSERGLSNHPSGIA-FTFWEQYLTLRwnLFQAICIIALAVFCVISILMFNPW 1161
Cdd:COG1033 165 VVTLDPDPLSSDLDRKEVVAEIRAIIAKYEDPGVEVYLTGFPvLRGDIAEAIQS--DLAIFFPLALLLILLLLFLFFRSL 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 1162 AATLIMCIVVITTIELG-GFMGLMGIKMNPISAVTLICAVGIGVEFTAHVELAFLTAL---GTIDQRLESCLQHMFVPVY 1237
Cdd:COG1033 243 RGVLLPLLVVLLAVIWTlGLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYREERrkgLDKREALREALRKLGPPVL 322
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 71997494 1238 HGAISTFLGVVMLVFSEFDfVVTYFFYTMTLLVALGVFNGLCVLPVILTLVGPKPE 1293
Cdd:COG1033 323 LTSLTTAIGFLSLLFSDIP-PIRDFGIVAAIGVLLAFLTSLTLLPALLSLLPRPKP 377
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
608-789 |
1.22e-12 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 72.59 E-value: 1.22e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 608 ADMLEEF--SQFNYIIIVIGYILMVIYAAFtqgRfqgwwlavqsNVALAICGVILVTISSICGLGFATHLGINFNAATTQ 685
Cdd:COG1033 597 AAINESVieSQIRSLLLALLLIFLLLLLAF---R----------SLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAV 663
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 686 VVPfLSLGLGIDDMFLLLHNY-DEIINICNKNE-IGVLLKETGMSVMLTSINNILAFISGYVLPIPALRSFCSQTAILLA 763
Cdd:COG1033 664 VAS-IALGIGVDYTIHFLSRYrEERRKGGDLEEaIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLL 742
|
170 180
....*....|....*....|....*.
gi 71997494 764 FNLIFLMFIFPAMIGIdLRRQRKGKR 789
Cdd:COG1033 743 VALLAALLLLPALLLL-LDPRIAKKR 767
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
609-1281 |
1.82e-08 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 59.08 E-value: 1.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 609 DMLEEFSQFNYIIIVIGYILMVIYAAFTqgrFQGWWLAVQSNVALaICGVILVtissicgLGFATHLGINFNAATTQVVP 688
Cdd:TIGR00921 186 DIEREFGKDMGTTMAISGILVVLVLLLD---FKRWWRPLLPLVII-LFGVAWV-------LGIMGWLGIPLYATTLLAVP 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 689 FLsLGLGIDDMFLLLHNYDEIINICNKNEIGVL--LKETGMSVMLTSINNILAFISGYVLPIPALRSF--CSQTAILLAF 764
Cdd:TIGR00921 255 ML-IGVGIDYGIQTLNRYEEERDIGRAKGEAIVtaVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFglGLVAGLITAY 333
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 765 nLIFLMFIFPAMIGIDLRRQRKGKRDLAYCSRgnpqmatsqsvPSNVSNNTQMSSRAElagyekqadeyKRHePWytvgg 844
Cdd:TIGR00921 334 -LLTLLVLPALLQSIDIGREKVKKEIIAIGGK-----------SSEIEEELSKVLSIT-----------VRH-PV----- 384
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 845 flnkiyiPALknnvVKACVLIGtttavvFGLYGMYTSTLGLELADVLPEHTPPAAFLRAREQYFSFYPMFA---VLRGDK 921
Cdd:TIGR00921 385 -------PAL----VAALIITG------LGLYGAAGIKPEVNIEKFIPQDLPSLQARKVIESHMGGSHDFAtilVKADDV 447
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 922 LDiPNQQQLIEEYRAQlgsskfmIKAEGKLQpywmsmlRVW-LQSL-DMALEKDLAAGkfdltngnPIKVNGEkPSPESM 999
Cdd:TIGR00921 448 RD-PELVRFMDELSRD-------IKATGVAA-------RVFgAPSIiDLVKEVEGLPA--------PERSALE-PIPEDE 503
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 1000 IAARLVCsfgtnyncdgrlGKMKMVENEVINPEGFYNYLtgwfnvdnMMYYVSQASFYPTPPGweyneklAKVVPAAEPL 1079
Cdd:TIGR00921 504 EGGYISG------------GQIKVAVIQVQLKQGEPKVQ--------GRKILRDVQHEHPPPG-------VKVGVTGLPV 556
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 1080 LYSQMpfyqNDLIDTpaivkmieeiratceeysERGLSNhpsgIAFTFweqyltlrwnlfqAICIIALAVF--CVISILM 1157
Cdd:TIGR00921 557 AFAEM----HELVNE------------------GMRRMT----IAGAI-------------LVLMILLAVFrnPIKAVFP 597
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 1158 FNPwaatliMCIVVITTIelgGFMGLMGIKMNPISAVTLICAVGIGVEFTAHV------ELAFLTALGTIDQRLESCLQH 1231
Cdd:TIGR00921 598 LIA------IGSGILWAI---GLMGLRGIPSFLAMATTISIILGLGMDYSIHLaeryfeERKEHGPKEAITHTMERTGPG 668
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*
gi 71997494 1232 MFVpvyhGAISTFLGVVMLVFSEFDFVVTYFFYTM-----TLLVALGVFNGLCVL 1281
Cdd:TIGR00921 669 ILF----SGLTTAGGFLSLLLSHFPIMRNFGLVQGigvlsSLTAALVVFPALLVL 719
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
1065-1288 |
8.37e-06 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 50.22 E-value: 8.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 1065 YNEKLAKVVPAAEPLLYSQMPFYQNDLI----------------DTPAIVKMIEEIRATCEEyserglSNHPSG------ 1122
Cdd:TIGR00921 105 GNFPLPVTMPEVRPLMSEYPRSKEMFLSkdhtvaiiivqlksdaDYKQVVPIYNDVERSLER------TNPPSGkfldvt 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 1123 ----IAFTFWEQYLTlRWNLFQAICIIALAVfcvISILMF-NPWAATLIMCIVVITTIELGGFMGLMGIKMNPISAVTLI 1197
Cdd:TIGR00921 179 gspaINYDIEREFGK-DMGTTMAISGILVVL---VLLLDFkRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVP 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 1198 CAVGIGVEFTAHVELAFLTALG---TIDQRLESCLQHMFVPVYHGAISTFLGVVMLVFSEFDfVVTYFFYTMTLLVALGV 1274
Cdd:TIGR00921 255 MLIGVGIDYGIQTLNRYEEERDigrAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFP-MVSEFGLGLVAGLITAY 333
|
250
....*....|....
gi 71997494 1275 FNGLCVLPVILTLV 1288
Cdd:TIGR00921 334 LLTLLVLPALLQSI 347
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
604-777 |
1.57e-05 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 49.45 E-value: 1.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 604 STSIADMLEEFSQFNYIIIVIGYILMVIYAaftqgrfqgwwLAVQSNVALAICGVILVTISSICGLGFATHLGINFNAaT 683
Cdd:TIGR00921 555 PVAFAEMHELVNEGMRRMTIAGAILVLMIL-----------LAVFRNPIKAVFPLIAIGSGILWAIGLMGLRGIPSFL-A 622
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 684 TQVVPFLSLGLGIDDMFLLLHNY-DEIINICNKNEIGVLLKETGMSVMLTSINNILAFISGYVLPIPALRSFCSQTAILL 762
Cdd:TIGR00921 623 MATTISIILGLGMDYSIHLAERYfEERKEHGPKEAITHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGV 702
|
170
....*....|....*
gi 71997494 763 AFNLIFLMFIFPAMI 777
Cdd:TIGR00921 703 LSSLTAALVVFPALL 717
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
1133-1297 |
4.53e-05 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 47.92 E-value: 4.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 1133 TLRWNLFQAICIIALAVFCVISILMFNP---WAATLIMCIVVITTIelgGFMGLMGIKMNPISAVTLICAVGIGVEFTah 1209
Cdd:COG4258 636 RYRNDALWLLLLALLLILLLLLLRLRSLrraLRVLLPPLLAVLLTL---AILGLLGIPLNLFHLIALLLVLGIGIDYA-- 710
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 1210 velAFLTALGTIDQRLESCLQHMFVpvyhGAISTFLGVVMLVFSEfdfvvTYFFYTMTLLVALGVFnglCVLPVILTLVG 1289
Cdd:COG4258 711 ---LFFTEGLLDKGELARTLLSILL----AALTTLLGFGLLAFSS-----TPALRSFGLTVLLGIL---LALLLAPLLAP 775
|
....*...
gi 71997494 1290 PKPELTPT 1297
Cdd:COG4258 776 RRRPRRAA 783
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
73-241 |
1.58e-04 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 46.44 E-value: 1.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 73 RAFFQLWlfriGCFVQRWAWSTIFISLFLYCLCLGGLRHVTIETDLVKLWVSEGGRLNEEMGYLGQvkferesgHLvhkv 152
Cdd:TIGR00917 310 ARFFGKY----GIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDT--------HF---- 373
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 153 kraveqtteppAPAVKAEvrrgpelpkenglgggfQVVIQTPSFDGQ----NILSKEALQQHTKLMEEISTYEVKMFNET 228
Cdd:TIGR00917 374 -----------GPFYRIE-----------------QLIIATVQTSSHekapEILTDDNLKLLFDIQKKVSQLFANYEGEL 425
|
170
....*....|...
gi 71997494 229 WTLSDICFKPPGP 241
Cdd:TIGR00917 426 ITLDSPCFKPNHP 438
|
|
| CstA |
COG1966 |
Carbon starvation protein CstA (peptide/pyruvate transporter) [Energy production and ... |
1142-1275 |
5.14e-03 |
|
Carbon starvation protein CstA (peptide/pyruvate transporter) [Energy production and conversion, Amino acid transport and metabolism];
Pssm-ID: 441569 [Multi-domain] Cd Length: 534 Bit Score: 40.92 E-value: 5.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 1142 ICIIALAVFCVI--SILMFNPWAATLIMCIVVItTIELGGFMGLMGIKMNPISAVTLIC---AVGIGVEFTAHVELAFLT 1216
Cdd:COG1966 139 LLLLVLAVFALVvaNALANSPWAAFTVALTIPI-AILMGLYLYRLPGNVLEASIIGVVLlylAIVLGPYVPFTLSGTTWV 217
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 71997494 1217 ALgtidqrlesclqhmfVPVYhGAISTFLGVVMLVfSEFDFVVTYFFYTMTLLVALGVF 1275
Cdd:COG1966 218 II---------------LFVY-GFIASVLPVWLLL-QPRDYLSSFLLIGMIIGLAIGII 259
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
1120-1253 |
9.16e-03 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 40.36 E-value: 9.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997494 1120 PSGIAFTFWEQYLTLRWNLFQAICIIALAVFCVISIL--MFNPWAATLIMCIVVITTIeLGGFMGLM--GIKMNPISAVT 1195
Cdd:pfam00873 843 PPGYGYTWTGQFEQEQLAGNSLPILIALALLVVFLVLaaLYESWSDPLSIMLTVPLAL-VGALLALWlrGLPNSVYAQVG 921
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 71997494 1196 LICAVGIG-------VEFTahVELAFLTALGTIDQRLESCLQHmFVPVYHGAISTFLGVVMLVFS 1253
Cdd:pfam00873 922 LILLIGLAvknailmVEFA--NELREQEGKSLEEAILEACRLR-LRPILMTALAAILGVLPLALS 983
|
|
| |
